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https://www.readbyqxmd.com/read/28644344/treatment-of-functional-abdominal-pain-with-antidepressants-benefits-adverse-effects-and-the-gastroenterologist-s-role
#1
Claire A M Zar-Kessler, Jaime Belkind-Gerson, Suzanne Bender, Braden M Kuo
OBJECTIVES: Pediatric functional abdominal pain is often treated with tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). The aim is investigating antidepressant use for treatment efficacy, correlation of response to psychiatric factors, and impact of adverse effects in regard to physicians' prescribing patterns. METHODS: Retrospective review (2005-2013) children (5-21 years old) with functional abdominal pain treated with SSRI or TCA...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28631072/down-regulation-of-soluble-fms-like-tyrosine-kinase-1-expression-in-invasive-placentation
#2
Scott A Shainker, Katelyn Dannheim, Kristin D Gerson, Dayna Neo, Zsuzsanna K Zsengeller, Elizabeth Pernicone, S Ananth Karumanchi, Michele R Hacker, Jonathan L Hecht
PURPOSE: To confirm reduced expression of soluble fms-like tyrosine kinase 1 (sFlt-1) in accreta/increta. METHODS: Formalin-fixed tissue sections from 11 peripartum hysterectomies with invasive placentation and 5 controls were stained for sFlt-1. Stain intensity was scored in selected 100× microscopic fields. We compared sFlt-1 expression in invasive areas among cases, non-invasive areas among cases and areas from control placentas. RESULTS: Chorionic villi displayed significantly decreased sFlt-1 expression in invasive areas of cases compared to control placentas (p = 0...
June 19, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28617800/whole-genome-sequencing-distinguishes-between-relapse-and-reinfection-in-recurrent-leprosy-cases
#3
Mariane M A Stefani, Charlotte Avanzi, Samira Bührer-Sékula, Andrej Benjak, Chloé Loiseau, Pushpendra Singh, Maria A A Pontes, Heitor S Gonçalves, Emerith M Hungria, Philippe Busso, Jérémie Piton, Maria I S Silveira, Rossilene Cruz, Antônio Schetinni, Maurício B Costa, Marcos C L Virmond, Suzana M Diorio, Ida M F Dias-Baptista, Patricia S Rosa, Masanori Matsuoka, Maria L F Penna, Stewart T Cole, Gerson O Penna
BACKGROUND: Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as a means of assessing therapeutic efficacy. All three objectives can be reached with single nucleotide resolution using next generation sequencing and bioinformatics analysis of Mycobacterium leprae DNA present in human skin. METHODOLOGY: DNA was isolated by means of optimized extraction and enrichment methods from samples from three recurrent cases in leprosy patients participating in an open-label, randomized, controlled clinical trial of uniform MDT in Brazil (U-MDT/CT-BR)...
June 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28617206/utilization-patterns-at-a-specialized-children-s-comprehensive-psychiatric-emergency-program
#4
Ruth Gerson, Jennifer Havens, Mollie Marr, Amy Storfer-Isser, Mia Lee, Carolena Rojas Marcos, Michelle Liu, Sarah McCue Horwitz
OBJECTIVE: Most youths experiencing a psychiatric crisis present to emergency departments (EDs) that lack the specialized staff to evaluate them, so youths are often discharged without appropriate mental health assessment or treatment. To better understand the needs of this population, this study described clinical details and disposition associated with visits for psychiatric emergencies to a specialized ED staffed 24/7 by child psychiatrists. METHODS: Through retrospective chart review, 1,180 visits to the ED during its first year of operation were reviewed for clinical characteristics, prior service utilization, and demographic characteristics...
June 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28616947/the-impact-of-metalation-on-adsorption-geometry-electronic-level-alignment-and-uv-stability-of-organic-macrocycles-on-tio2-110
#5
Manuel Graf, Gerson Mette, Dominik Leuenberger, Yeliz Gurdal, Marcella Iannuzzi, Wolf-Dietrich Zabka, Stephan Schnidrig, Benjamin Probst, Jürg Hutter, Roger Alberto, Jürg Osterwalder
Metal complexes of the tetradentate bipyridine based macrocycle pyrphyrin (Pyr) have recently shown promise as water reduction catalysts in homogeneous photochemical water splitting reactions. In this study, the adsorption and metalation of pyrphyrin on stoichiometric TiO2(110) is investigated in ultrahigh vacuum by means of scanning tunneling microscopy, photoelectron spectroscopy, low-energy electron diffraction, and density functional theory. In a joint experimental and computational effort, the local adsorption geometry at low coverage, the long-range molecular ordering at higher coverage and the electronic structure have been determined for both the bare ligand and the cobalt-metalated Pyr molecule on TiO2...
June 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28614467/-epidemiological-surveillance-of-vertical-transmission-of-syphilis-data-from-six-federal-units-in-brazil
#6
Valeria Saraceni, Gerson Fernando Mendes Pereira, Mariangela Freitas da Silveira, Maria Alix Leite Araujo, Angelica Espinosa Miranda
Objective: To describe the epidemiological profile of reported cases of syphilis in pregnancy and congenital syphilis in five states (Amazonas, Ceará, Espírito Santo, Rio de Janeiro, and Rio Grande do Sul) and the Federal District using data from the Reportable Disease Information System (SINAN). Method: This descriptive study including an ecological and cross-sectional evaluation employed data from SINAN Net. The syphilis detection rate in pregnancy and the congenital syphilis incidence rate per 1 000 live births were calculated...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28601347/taxonomic-and-functional-distinctness-of-the-fish-assemblages-in-three-coastal-environments-bays-coastal-lagoons-and-oceanic-beaches-in-southeastern-brazil
#7
Márcia Cristina Costa Azevedo, Rafaela de Sousa Gomes-Gonçalves, Tailan Moretti Mattos, Wagner Uehara, Gustavo Henrique Soares Guedes, Francisco Gerson Araújo
Several species of marine fish use different coastal systems especially during their early development. However, these habitats are jeopardized by anthropogenic influences threatening the success of fish populations, and urgent measures are needed to priorize areas to protect their sustainability. We applied taxonomic (Δ+) and functional (X+) distinctiveness indices that represent taxonomic composition and functional roles to assess biodiversity of three different costal systems: bays, coastal lagoons and oceanic beaches...
May 30, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28595195/gas6-oncogene-and-reverse-mllt3-kmt2a-duplications-in-an-infant-with-acute-myeloid-leukemia-and-a-novel-complex-hyperdiploid-karyotype-detailed-high-resolution-molecular-cytogenetic-studies
#8
Roberto R Capela de Matos, Daniela R Ney Garcia, Elaine Cifoni, Moneeb A K Othman, Mariana Tavares de Souza, Edna K Carboni, Gerson M Ferreira, Thomas Liehr, Raul C Ribeiro, Maria Luiza M Silva
Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease, presenting cytogenetic and molecular abnormalities which turned out to be critical prognostic factors. Ploidy changes as gain or loss of individual chromosomes are rare in AML, occurring only in about 1-2% of the affected children. Hyperdiploid karyotypes are exceedingly rare in infants less than 12 months of age. In this age group, structural rearrangements involving the KMT2A gene occur in about 58% of the cases. Among them, the translocation t(9;11)(p22;q23), KMT2A-MLLT3, is the most common abnormality accounting for approximately 22% of KMT2A rearrangements in infant AML cases...
June 9, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28584929/steep-effort-discounting-of-a-preferred-reward-over-a-freely-available-option-in-prolonged-methamphetamine-withdrawal-in-male-rats
#9
Andrew B Thompson, Julian Gerson, Alexandra Stolyarova, Amador Bugarin, Evan E Hart, J David Jentsch, Alicia Izquierdo
RATIONALE: Drug addiction can be described as aberrant allocation of effort toward acquiring drug, despite associated costs. It is unclear if this behavioral pattern results from an overvaluation of reward or to an altered sensitivity to costs. OBJECTIVE: Present experiments assessed reward sensitivity and effortful choice in rats following 1 week of withdrawal from methamphetamine (mAMPH). METHODS: Rats were treated with either saline or an escalating dose mAMPH regimen, then tested after a week without the drug...
June 6, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28580182/cerebral-microvascular-accumulation-of-tau-oligomers-in-alzheimer-s-disease-and-related-tauopathies
#10
Diana L Castillo-Carranza, Ashley N Nilson, Candice E Van Skike, Jordan B Jahrling, Kishan Patel, Prajesh Garach, Julia E Gerson, Urmi Sengupta, Jose Abisambra, Peter Nelson, Juan Troncoso, Zoltan Ungvari, Veronica Galvan, Rakez Kayed
The importance of vascular contributions to cognitive impairment and dementia (VCID) associated with Alzheimer's disease (AD) and related neurodegenerative diseases is increasingly recognized, however, the underlying mechanisms remain obscure. There is growing evidence that in addition to Aβ deposition, accumulation of hyperphosphorylated oligomeric tau contributes significantly to AD etiology. Tau oligomers are toxic and it has been suggested that they propagate in a "prion-like" fashion, inducing endogenous tau misfolding in cells...
May 2017: Aging and Disease
https://www.readbyqxmd.com/read/28578880/quality-of-care-in-nursing-homes-in-brazil
#11
Wagner Ivan Fonseca de Oliveira, Pedro Jesus Saturno Hernández, Kelienny de Meneses Sousa, Gérson da Silva, Zenewton André da Silva Gama
BACKGROUND: There is an increased demand for nursing homes (NHs) in middle-income countries such as Brazil. To monitor the quality of NHs, there is a need for reliable instruments to assess the extent to which the care provided meets the expectations and rights of residents and their families. PURPOSE: To evaluate the reliability, applicability, and measurement results of an instrument for assessing the quality of NH care assessment. METHODS: We conducted a cross-sectional study in 31 NHs, applying the Observable Indicators of Nursing Home Care Quality Instrument (OINHQ) adapted to the Brazilian context...
May 31, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28576294/development-of-quality-indicators-for-endoscopic-eradication-therapies-in-barrett-s-esophagus-the-treat-be-treatment-with-resection-and-endoscopic-ablation-techniques-for-barrett-s-esophagus-consortium
#12
Sachin Wani, V Raman Muthusamy, Nicholas J Shaheen, Rena Yadlapati, Robert Wilson, Julian A Abrams, Jacques Bergman, Amitabh Chak, Kenneth Chang, Ananya Das, John Dumot, Steven A Edmundowicz, Glenn Eisen, Gary W Falk, M Brian Fennerty, Lauren Gerson, Gregory G Ginsberg, David Grande, Matt Hall, Ben Harnke, John Inadomi, Janusz Jankowski, Charles J Lightdale, Jitin Makker, Robert D Odze, Oliver Pech, Richard E Sampliner, Stuart Spechler, George Triadafilopoulos, Michael B Wallace, Kenneth Wang, Irving Waxman, Srinadh Komanduri
No abstract text is available yet for this article.
May 11, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28570552/development-of-quality-indicators-for-endoscopic-eradication-therapies-in-barrett-s-esophagus-the-treat-be-treatment-with-resection-and-endoscopic-ablation-techniques-for-barrett-s-esophagus-consortium
#13
Sachin Wani, V Raman Muthusamy, Nicholas J Shaheen, Rena Yadlapati, Robert Wilson, Julian A Abrams, Jacques Bergman, Amitabh Chak, Kenneth Chang, Ananya Das, John Dumot, Steven A Edmundowicz, Glenn Eisen, Gary W Falk, M Brian Fennerty, Lauren Gerson, Gregory G Ginsberg, David Grande, Matt Hall, Ben Harnke, John Inadomi, Janusz Jankowski, Charles J Lightdale, Jitin Makker, Robert D Odze, Oliver Pech, Richard E Sampliner, Stuart Spechler, George Triadafilopoulos, Michael B Wallace, Kenneth Wang, Irving Waxman, Srinadh Komanduri
Am J Gastroenterol advance online publication, 1 June 2017; doi:10.1038/ajg.2017.166.
June 1, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28566702/colitis-promotes-neuronal-differentiation-of-sox2-and-plp1-enteric-cells
#14
Jaime Belkind-Gerson, Hannah K Graham, Justin Reynolds, Ryo Hotta, Nandor Nagy, Lily Cheng, Michal Kamionek, Hai Ning Shi, Carol M Aherne, Allan M Goldstein
Mechanisms mediating adult enteric neurogenesis are largely unknown. Using inflammation-associated neurogenesis models and a transgenic approach, we aimed to understand the cell-source for new neurons in infectious and inflammatory colitis. Dextran sodium sulfate (DSS) and Citrobacter rodentium colitis (CC) was induced in adult mice and colonic neurons were quantified. Sox2GFP and PLP1GFP mice confirmed the cell-type specificity of these markers. Sox2CreER:YFP and PLP1creER:tdT mice were used to determine the fate of these cells after colitis...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28564678/association-between-skin-and-aortic-vascular-inflammation-in-patients-with-psoriasis-a-case-cohort-study-using-positron-emission-tomography-computed-tomography
#15
Amit K Dey, Aditya A Joshi, Abhishek Chaturvedi, Joseph B Lerman, Tsion M Aberra, Justin A Rodante, Heather L Teague, Charlotte L Harrington, Joshua P Rivers, Jonathan H Chung, Mohammad Tarek Kabbany, Balaji Natarajan, Joanna I Silverman, Qimin Ng, Gregory E Sanda, Alexander V Sorokin, Yvonne Baumer, Emily Gerson, Ronald B Prussick, Alison Ehrlich, Lawrence J Green, Benjamin N Lockshin, Mark A Ahlman, Martin P Playford, Joel M Gelfand, Nehal N Mehta
Importance: Inflammation is critical in the development of atherosclerosis. Psoriasis is a chronic inflammatory skin disease that is associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography in vivo and future cardiovascular events. It provides a human model to understand the effect of treating inflammation in a target organ (eg, the skin) on vascular diseases. Objective: To investigate the association between change in skin disease severity and change in vascular inflammation at 1 year and to characterize the impact of 1 year of anti-tumor necrosis factor therapy on vascular inflammation...
May 31, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28559469/physiological-requirements-to-perform-the-glittre-activities-of-daily-living-test-by-subjects-with-mild-to-severe-copd
#16
Gérson F Souza, Graciane L Moreira, Andréa Tufanin, Mariana R Gazzotti, Antonio A Castro, José R Jardim, Oliver A Nascimento
BACKGROUND: The Glittre activities of daily living (ADL) test is supposed to evaluate the functional capacity of COPD patients. The physiological requirements of the test and the time taken to perform it by COPD patients in different disease stages are not well known. The objective of this work was to compare the metabolic, ventilatory, and cardiac requirements and the time taken to carry out the Glittre ADL test by COPD subjects with mild, moderate, and severe disease. METHODS: Spirometry, Medical Research Council questionnaire, cardiopulmonary exercise test, and 2 Glittre ADL tests were evaluated in 62 COPD subjects...
May 30, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28553236/standardization-of-a-continuous-assay-for-glycosidases-and-its-use-for-screening-insect-gut-samples-at-individual-and-populational-levels
#17
Gerson S Profeta, Jessica A S Pereira, Samara G Costa, Patricia Azambuja, Eloi S Garcia, Caroline da Silva Moraes, Fernando A Genta
Glycoside Hydrolases (GHs) are enzymes able to recognize and cleave glycosidic bonds. Insect GHs play decisive roles in digestion, in plant-herbivore, and host-pathogen interactions. GH activity is normally measured by the detection of a release from the substrate of products as sugars units, colored, or fluorescent groups. In most cases, the conditions for product release and detection differ, resulting in discontinuous assays. The current protocols result in using large amounts of reaction mixtures for the obtainment of time points in each experimental replica...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28543944/anterior-cingulate-cortex-supports-effort-allocation-towards-a-qualitatively-preferred-option
#18
Evan E Hart, Julian O Gerson, Yael Zoken, Marisella Garcia, Alicia Izquierdo
The anterior cingulate cortex (ACC) is known to be involved in effortful choice, yet its role in cost-benefit evaluation of qualitatively different rewards (more/less preferred), beyond magnitude differences (larger/smaller), is poorly understood. Selecting between qualitatively different options is a decision type commonly faced by humans. Here, we assessed the role of ACC on a task that has primarily been used to probe striatal function in motivation. Rats were trained to stable performance on a progressive ratio schedule for sucrose pellets and were then given sham surgeries (control) or excitotoxic NMDA lesions of ACC...
May 20, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28539507/comment-on-an-analysis-of-endotherm-thermal-tolerances-systematic-errors-in-data-compilation-undermine-its-credibility
#19
Blair O Wolf, Brittney H Coe, Alexander R Gerson, Andrew E McKechnie
No abstract text is available yet for this article.
May 31, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28534521/comprehensive-analysis-of-adverse-events-associated-with-per-oral-endoscopic-myotomy-in-1826-patients-an-international-multicenter-study
#20
Yamile Haito-Chavez, Haruhiro Inoue, Kristin W Beard, Peter V Draganov, Michael Ujiki, Burkhard H A Rahden, Pankaj N Desai, Mathieu Pioche, Bu Hayee, Amyn Haji, Payal Saxena, Kevin Reavis, Manabu Onimaru, Valerio Balassone, Jun Nakamura, Yoshitaka Hata, Dennis Yang, Davinderbir Pannu, Ali Abbas, Yaseen B Perbtani, Lava Y Patel, Jorg Filser, Sabine Roman, Jerome Rivory, Francois Mion, Thierry Ponchon, Silvana Perretta, Vivien Wong, Roberta Maselli, Saowanee Ngamruengphong, Yen-I Chen, Majidah Bukhari, Gulara Hajiyeva, Amr Ismail, Renata Pieratti, Vivek Kumbhari, Gerson Galdos-Cardenas, Alessandro Repici, Mouen A Khashab
OBJECTIVES: The safety of peroral endoscopic myotomy (POEM) is still debated since comprehensive analysis of adverse events (AEs) associated with the procedure in large multicenter cohort studies has not been performed. To study (1) the prevalence of AEs and (2) factors associated with occurrence of AEs in patients undergoing POEM. METHODS: Patients who underwent POEM at 12 tertiary-care centers between 2009 and 2015 were included in this case-control study. Cases were defined by the occurrence of any AE related to the POEM procedure...
May 23, 2017: American Journal of Gastroenterology
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