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Mary K Donnelly, Karan S Kverno, Anne E Belcher, Lindsay R Ledebur, Linda D Gerson
BACKGROUND: Online graduate courses provide opportunities for faculty to use technology and digital applications to enhance student learning and learning environments. In nursing education, as we become increasingly dependent on technology, it is important to ensure that both faculty and students add digital literacy to their repertoire of knowledge and skills. VoiceThread(©), one type of Web-based digital application tool, allows students and faculty to verbally communicate and collaborate asynchronously...
November 1, 2016: Journal of Nursing Education
Jacqueline R Gerson, Charles T Driscoll, Karen M Roy
With decreases in acid deposition, nitrogen : phosphorus (N:P) ratios in lakes are anticipated to decline, decreasing P limitation of phytoplankton and potentially changing current food web dynamics. This effect could be particularly pronounced in the Adirondack Mountains of New York State, a historic hotspot for effects of acid deposition. In this study, we evaluate spatial patterns of nutrient dynamics in Adirondack lakes and use these to infer potential future temporal trends. We calculated Mann-Kendall tau correlations among total phosphorus (TP), chlorophyll a, dissolved organic carbon (DOC), acid neutralizing capacity (ANC), and nitrate (NO3(-) ) concentrations in 52 Adirondack Long Term Monitoring (ALTM) program lakes using samples collected monthly during 2008-2012...
September 2016: Ecological Applications: a Publication of the Ecological Society of America
Gerson Dierley Keppeke, Monica Simon Prado, Eunice Nunes, Sandro Felix Perazzio, Silvia Helena Rodrigues, Maria Lucia Gomes Ferraz, Edward K L Chan, Luis Eduardo Coelho Andrade
Some HCV patients using ribavirin and interferon alpha (IFN-α) develop anti-rods and rings (RR) autoantibodies, the main target of which is inosine monophosphate dehydrogenase (IMPDH), the rate-determining enzyme in de novo GTP biosynthesis. In vitro inhibition of IMPDH by ribavirin induces RR formation. Here we investigate whether other commonly used drugs that interfere with GTP biosynthesis can induce RR structures in vitro and vivo and elicit generation of autoantibodies. HEp-2 cells treated for 24h with ribavirin, mycophenolic acid (MPA), azathioprine, methotrexate or acyclovir were positive for RR structures...
October 13, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Glauco Adrieno Westphal, Valter Duro Garcia, Rafael Lisboa de Souza, Cristiano Augusto Franke, Kalinca Daberkow Vieira, Viviane Renata Zaclikevis Birckholz, Miriam Cristine Machado, Eliana Régia Barbosa de Almeida, Fernando Osni Machado, Luiz Antônio da Costa Sardinha, Raquel Wanzuita, Carlos Eduardo Soares Silvado, Gerson Costa, Vera Braatz, Milton Caldeira Filho, Rodrigo Furtado, Luana Alves Tannous, André Gustavo Neves de Albuquerque, Edson Abdala
Organ transplantation is the only alternative for many patients with terminal diseases. The increasing disproportion between the high demand for organ transplants and the low rate of transplants actually performed is worrisome. Some of the causes of this disproportion are errors in the identification of potential organ donors and in the determination of contraindications by the attending staff. Therefore, the aim of the present document is to provide guidelines for intensive care multi-professional staffs for the recognition, assessment and acceptance of potential organ donors...
September 2016: Revista Brasileira de Terapia Intensiva
Ashley N Nilson, Kelsey C English, Julia E Gerson, T Barton Whittle, C Nicolas Crain, Judy Xue, Urmi Sengupta, Diana L Castillo-Carranza, Wenbo Zhang, Praveena Gupta, Rakez Kayed
It is well-established that inflammation plays an important role in Alzheimer's disease (AD) and frontotemporal lobar dementia (FTLD). Inflammation and synapse loss occur in disease prior to the formation of larger aggregates, but the contribution of tau to inflammation has not yet been thoroughly investigated. Tau pathologically aggregates to form large fibrillar structures known as tangles. However, evidence suggests that smaller soluble aggregates, called oligomers, are the most toxic species and form prior to tangles...
October 1, 2016: Journal of Alzheimer's Disease: JAD
Luís F J R Miranda, Karina B Gomes, Pedro A L Tito, Josianne N Silveira, Gerson A Pianetti, Ricardo M D Byrro, Patrícia R H Peles, Fernando H Pereira, Thiago R Santos, Arthur G Assini, Valéria V Ribeiro, Edgar N Moraes, Paulo Caramelli
The clinical response to donepezil in patients with mild and moderate dementia was investigated in relation to the drug plasma concentration and of APOE and CYP2D6 polymorphisms. In a prospective naturalistic observational study, 42 patients with Alzheimer's disease (AD) and AD with cerebrovascular disease who took donepezil (10 mg) for 12 months were evaluated. Their DNA was genotyped, and the donepezil plasma concentrations were measured after 3, 6, and 12 months. Good responders scored ≥-1 on the Mini-Mental State Examination at 12 months in comparison to the baseline score...
October 4, 2016: Journal of Alzheimer's Disease: JAD
William T Gerson
No abstract text is available yet for this article.
September 2016: Current Problems in Pediatric and Adolescent Health Care
Gin S Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A Frye, Michael Gitlin, Sidney H Kennedy, Terence A Ketter, Raymond W Lam, Rupert McShane, Alex J Mitchell, Michael J Ostacher, Sakina J Rizvi, Michael E Thase, Mauricio Tohen
SUMMARY: The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations...
May 2016: BJPsych Open
Vinicius P Fardin, Vitor Guarconi de Paula, Estevam A Bonfante, Paulo G Coelho, Gerson Bonfante
OBJECTIVE: To evaluate the fatigue life of zirconia-veneered and metal-ceramic crowns comprised by an even thickness or a modified framework design when loaded on marginal ridges. METHODS: Eighty marginal ridges were present after fabrication of forty molar crowns cemented onto composite-resin replicas and divided (n=20/each), in the following groups: metal-ceramic with even thickness (MCev) or with a modified framework design (MCm, lingual collar with proximal struts); porcelain-fused to zirconia with even thickness (PFZev) or with the modified framework design (PFZm)...
September 30, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Gerson Aparecido Foratori, Francisco Juliherme Pires de Andrade, Victor Mosquim, Matheus de Carvalho Sales Peres, Reginaldo Ceneviva, Elinton Adami Chaim, Silvia Helena de Carvalho Sales Peres
Society has changed its own lifestyle, specially its eating habits and physical activities, leading to excessive weight and a sedentary behavior, which has contributed to obesity increase. Bariatric surgery is the most effective treatment to obesity, allowing weight loss and its maintenance. However, it has been related high levels of iron deficiency after surgery. A person's nutritional status might be affected by total or partial tooth loss. The aim of this longitudinal prospective cohort study was to evaluate the levels of serum ferritin before and after bariatric surgery and to identify if there is a relation with tooth loss...
2016: PloS One
Flavia Vanessa Medeiros, Martim Bottaro, Amilton Vieira, Tiago Pires Lucas, Karenina Arrais Modesto, Antonio Padilha L Bo, Gerson Cipriano, Nicolas Babault, João Luiz Quaglioti Durigan
OBJECTIVE: To test the hypotheses that, as compared with pulsed current with the same pulse duration, kilohertz frequency alternating current would not differ in terms of evoked-torque production and perceived discomfort, and as a result, it would show the same current efficiency. DESIGN: A repeated-measures design with 4 stimuli presented in random order was used to test 25 women: (1) 500-microsecond pulse duration, (2) 250-microsecond pulse duration, (3) 500-microsecond pulse duration and low carrier frequency (1 kHz), (4) 250-microsecond pulse duration and high carrier frequency (4 kHz)...
September 26, 2016: American Journal of Physical Medicine & Rehabilitation
Julia E Gerson, Amrit Mudher, Rakez Kayed
The culmination of many years of increasing research into the toxicity of tau aggregation in neurodegenerative disease has led to the consensus that soluble, oligomeric forms of tau are likely the most toxic entities in disease. While tauopathies overlap in the presence of tau pathology, each disease has a unique combination of symptoms and pathological features; however, most study into tau has grouped tau oligomers and studied them as a homogenous population. Established evidence from the prion field combined with the most recent tau and amyloidogenic protein research suggests that tau is a prion-like protein, capable of seeding the spread of pathology throughout the brain...
September 21, 2016: Critical Reviews in Biochemistry and Molecular Biology
Jacqueline R Gerson, Charles T Driscoll
Although there has been a decline in U.S. mercury emissions, the effects of this change on remote ecosystems are not well understood. We examine decadal (2004-2015) responses of atmospheric mercury deposition, along with total mercury (THg) and methylmercury (MeHg) concentrations and fluxes, to decrease in mercury emissions at Arbutus Lake-watershed in the remote forested Adirondack region of New York, a biological mercury hotspot. Although wet mercury deposition remains constant, THg deposition has decreased through decreases in litter mercury inputs (17...
October 5, 2016: Environmental Science & Technology
Claire A M Zar-Kessler, Jaime Belkind-Gerson, Suzanne Bender, Braden M Kuo
OBJECTIVES: Pediatric functional abdominal pain is often treated with tricyclic antidepressants (TCA) and selective serotonin reuptake inhibitors (SSRI). The aim is investigating antidepressant use for treatment efficacy, correlation of response to psychiatric factors and impact of side effects in regard to physicians' prescribing patterns. METHODS: Retrospective review (2005-2013) children (5-21yo) with functional abdominal pain treated with SSRI or TCA. Of the 531 cases with functional abdominal pain, 192 initiated SSRIs or TCAs while followed by gastroenterology...
September 16, 2016: Journal of Pediatric Gastroenterology and Nutrition
Fahad Waqar, Hina K Jamali, Myron C Gerson
No abstract text is available yet for this article.
September 8, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Francisco Gerson Araújo, Samara Macedo Pinto, Leonardo Mitrano Neves, Márcia Cristina Costa de Azevedo
We assessed inter-annual changes in fish assemblages of a tropical bay which experienced a heavily industrialized process in the last decades. A highly significant difference in community structure among the bay zones, and a decrease in fish richness and abundance over time were found. Changes in fish richness and abundance between the two first (1987-1988 and 1993-1995) and the two latter time periods (1998-2001 and 2012-2013) were sharpest in the inner bay zone, the most impacted bay area, and in the middle zone, whereas the outer zone remained comparatively stable over time...
September 7, 2016: Marine Pollution Bulletin
Gerson Fernando Mendes Pereira, Meritxell Sabidó, Alessandro Caruso, Silvano Barbosa de Oliveira, Fábio Mesquita, Adele Schwartz Benzaken
Background This study was conducted to determine the seroprevalence of HIV among pregnant women in Brazil and to describe HIV testing coverage and the uptake of antenatal care (ANC). Methods Between October 2010 and January 2012, a probability sample survey of parturient women aged 15-49 years who visited public hospital delivery services in Brazil was conducted. Data were collected from prenatal reports and hospital records. Dried blood spot (DNS) samples were collected and tested for HIV. We describe the age-specific prevalence of HIV infection and ANC uptake with respect to sociodemographic factors...
August 2016: Revista Brasileira de Ginecologia e Obstetrícia
Célia Landmann Szwarcwald, Orlando da Costa Ferreira, Ana Maria de Brito, Karin Regina Luhm, Clea Elisa Lopes Ribeiro, Ana Maria Silva, Ana Maria Salustiano Cavalcanti, Tomoko Sasazawa Ito, Sonia Mara Raboni, Paulo Roberto Borges de Souza, Gerson Fernando Mendes Pereira
OBJECTIVE: To estimate HIV incidence in two Brazilian municipalities, Recife and Curitiba, in the year of 2013. METHODS: The method for estimating incidence was based on primary information, resulting from the Lag-Avidity laboratory test for detection of recent HIV infections, applied in a sample of the cases diagnosed in the two cities in 2013. For the estimation of the HIV incidence for the total population of the cities, the recent infections detected in the research were annualized and weighted by the inverse of the probability of HIV testing in 2013 among the infected and not diagnosed cases...
August 4, 2016: Revista de Saúde Pública
Gerson Weiss, Sam Teichman, Dennis Stewart, David Nader, Susan Wood, Peter Breining, Elaine Unemori
BACKGROUND: Nonclinical studies indicate that the hormone relaxin is a good candidate for a safe cervical ripening agent that does not cause uterine contractions. METHODS: This Phase II study (conducted November 2, 2005-October 20, 2006) was a randomised, double blind, placebo controlled trial testing 24-h intravenous infusion of serelaxin (recombinant human relaxin) or placebo for cervical ripening in 72 healthy, primiparous women. Eligible subjects had a singleton pregnancy ≥40 weeks, were planned for elective induction, had vertex presentation of the fetus, intact membranes and a Bishop score at screening ≤4...
2016: BMC Pregnancy and Childbirth
Laura de Mattos Milman, Giana Paula Müller, Paulo Ricardo Martins Souza, Aline Barcellos Grill, Deise Louise Bohn Rhoden, Carlos Augusto Mello-da-Silva, Gerson Vettorato
Acute generalized exanthematous pustulosis (AGEP) is an acute febrile rash, usually induced by drugs, which recently has been linked to spider bite. We report a case of a male patient, 48 years old, with an erythematous rash accompanied by fever and small non-follicular pustules. He reported previous pain in the buttock with the onset of a necrotic plaque. The lesion was compatible with spider bite of the genus Loxosceles. According to the EuroSCAR group instrument, the patient scored +10 indicating definite diagnosis of AGEP...
July 2016: Anais Brasileiros de Dermatologia
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