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https://www.readbyqxmd.com/read/28433614/association-between-breast-cancer-and-the-risk-of-colorectal-cancer-systematic-review-and-meta-analysis
#1
REVIEW
Jennifer H Lai, Gavin Park, Lauren B Gerson
BACKGROUND: The prior literature has suggested a potential increase in colorectal cancer (CRC) among patients with breast cancer. METHODS: We performed a systematic review of the literature and included 37 retrospective cohort studies and 8 case-control studies. The primary aim was to determine the prevalence of CRC. Secondary aims included analysis of adenomatous polyps and analysis of CRC prevalence by age. We calculated pooled prevalence rates and odds ratios using random effects models with 95% confidence intervals (CI)...
April 19, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28431250/nuclear-proximity-of-mtr4-to-rna-exosome-restricts-dna-mutational-asymmetry
#2
Junghyun Lim, Pankaj Kumar Giri, David Kazadi, Brice Laffleur, Wanwei Zhang, Veronika Grinstein, Evangelos Pefanis, Lewis M Brown, Erik Ladewig, Ophélie Martin, Yuling Chen, Raul Rabadan, François Boyer, Gerson Rothschild, Michel Cogné, Eric Pinaud, Haiteng Deng, Uttiya Basu
The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA contributes to the development of immune and neural systems along with the progression of cancer. Because developmentally matured B cells undergo biologically programmed strand-specific DNA mutagenesis at focal DNA/RNA hybrid structures, they make a convenient system to investigate strand-specific mutagenesis mechanisms. We demonstrate that the sense and antisense strand DNA mutagenesis at the immunoglobulin heavy chain locus and some other regions of the B cell genome depends upon localized RNA processing protein complex formation in the nucleus...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28421464/a-novel-tp53-mutation-associated-with-twist1-and-sip1-expression-in-an-aggressive-adrenocortical-carcinoma
#3
Daniel Bulzico, Davi Coe Torres, Gerson Moura Ferreira, Bruno Ricardo Barreto Pires, Paulo Antônio Silvestre de Faria, Rocio Hassan, Eliana Abdelhay, Mario Vaisman, Leonardo Vieira Neto
Adrenocortical carcinomas (ACC) are very rare tumors related to TP53 mutations mostly in childhood onset cases. Epithelial-mesenchymal transition (EMT) transcription factors TWIST1 and Smad interacting protein 1 (SIP1) are related to poorer outcomes in other malignancies, but their role in ACC is unknown. We describe a case of an advanced metastatic ACC (Weiss-score of 9) in a patient at age 76. After primary tumor resection, mitotane therapy was started as palliation to low-volume liver metastasis. After a 2-year period of stable disease, the patient died due to brain metastasis...
April 18, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28387541/perspectives-of-her2-targeting-in-gastric-and-esophageal-cancer
#4
James N Gerson, Sam Skariah, Crystal S Denlinger, Igor Astsaturov
The blockade of HER2 signaling has significantly improved the outlook for esophagogastric cancer patients. However, targeting HER2 still remains challenging due to complex biology of this receptor in gastric and esophageal cancers. Areas covered: Here, we review complex HER2 biology, current methods of HER2 testing and tumor heterogeneity of gastroesophageal cancer. Ongoing and completed clinical research data are discussed. Expert opinion: HER2 overexpression is a validated target in gastroesophageal cancer, with therapeutic implications resulting in prolonged survival when inhibited in the front-line setting...
May 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28384417/dehydration-causes-increased-reliance-on-protein-oxidation-in-mice-a-test-of-the-protein-for-water-hypothesis-in-a-mammal
#5
Marshall D McCue, Joey Sandoval, Jazmin Beltran, Alexander R Gerson
During fasting, animals rely on a mixture of fats, carbohydrates, and proteins that are derived solely from endogenous sources. The relative contributions of these metabolic fuels chiefly depend on the duration of the fast, but other factors including previous diet, environmental temperature, and activity level can modulate the fuel mixture. It has long been held that endogenous proteins are spared from catabolism until the final stages of prolonged fasting and contribute a significant proportion of energy once the other metabolic fuels have been depleted...
May 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28381130/pilot-trial-of-intravenous-autologous-culture-expanded-mesenchymal-stem-cell-transplantation-in-multiple-sclerosis
#6
Jeffrey A Cohen, Peter B Imrey, Sarah M Planchon, Robert A Bermel, Elizabeth Fisher, Robert J Fox, Amit Bar-Or, Susan L Sharp, Thomai T Skaramagas, Patricia Jagodnik, Matt Karafa, Shannon Morrison, Jane Reese Koc, Stanton L Gerson, Hillard M Lazarus
BACKGROUND: Mesenchymal stem cells (MSCs) exhibit immunomodulatory, tissue-protective, and repair-promoting properties in vitro and in animals. Clinical trials in several human conditions support the safety and efficacy of MSC transplantation. Published experience in multiple sclerosis (MS) is modest. OBJECTIVE: To assess feasibility, safety, and tolerability and explore efficacy of autologous MSC transplantation in MS. METHODS: Participants with relapsing-remitting multiple sclerosis (RRMS) or secondary progressive multiple sclerosis (SPMS), Expanded Disability Status Scale score 3...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28378785/corrigendum-gene-expression-differences-in-longissimus-muscle-of-nelore-steers-genetically-divergent-for-residual-feed-intake
#7
Polyana C Tizioto, Luiz L Coutinho, Priscila S N Oliveira, Aline S M Cesar, Wellison J S Diniz, Andressa O Lima, Marina I Rocha, Jared E Decker, Robert D Schnabel, Gerson B Mourão, Rymer R Tullio, Adhemar Zerlotini, Jeremy F Taylor, Luciana C A Regitano
No abstract text is available yet for this article.
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28377814/what-and-who-mindfulness-in-the-mental-health-setting
#8
Tamara A Russell, Gerson Siegmund
A strong and growing evidence base exists for the use of mindfulness-based interventions to prevent relapse in major depression and for the self-management of chronic physical health conditions (e.g. pain), but the evidence in other domains of mental health work is still emerging. Much work is being conducted outside the evidence base and standardised protocols, and by individuals with varied levels of experience and training. The (mis)perception of mindfulness as a 'simple technique' belies the complexity and skill needed to deliver a mindfulness training that has real therapeutic and transformative power...
December 2016: BJPsych Bulletin
https://www.readbyqxmd.com/read/28371960/a-model-for-the-management-of-female-sexual-dysfunctions
#9
Lúcia Alves da Silva Lara, Sandra Cristina Poerner Scalco, Júlia Kefalás Troncon, Gerson Pereira Lopes
Introduction Sexual pleasure is fundamental for the maintenance of health and well-being, but it may be adversely affected by medical and psychosocial conditions. Many patients only feel that their health is fully restored after they resume normal sexual activities. Any discussion of sexuality in a doctor's office is typically limited, mainly because of a lack of models or protocols available to guide the discussion of the topic. Objectives To present a model designed to guide gynecologists in the management of female sexual complaints...
April 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28369287/towards-improving-early-diagnosis-of-congenital-chagas-disease-in-an-endemic-setting
#10
Louisa A Messenger, Robert H Gilman, Manuela Verastegui, Gerson Galdos-Cardenas, Gerardo Sanchez, Edward Valencia, Leny Sanchez, Edith Malaga, Victoria R Rendell, Malasa Jois, Vishal Shah, Nicole Santos, Maria Del Carmen Abastoflor, Carlos LaFuente, Rony Colanzi, Ricardo Bozo, Caryn Bern
Background: Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy is highly efficacious and well tolerated, but current assays for early detection fail to detect >50% of infected neonates and 9 month follow-up is low. Methods: Women presenting for delivery in two urban hospitals in Santa Cruz department, Bolivia were screened by rapid test...
March 25, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28368525/menstrual-cycle-hormone-changes-in-women-traversing-the-menopause-study-of-women-s-health-across-the-nation
#11
Nanette Santoro, Sybil L Crawford, Samar R El Khoudary, Amanda A Allshouse, Sherri-Ann Burnett-Bowie, Joel Finkelstein, Carol Derby, Karen Matthews, Howard M Kravitz, Sioban D Harlow, Gail A Greendale, Ellen B Gold, Rasa Kazlauskaite, Dan McConnell, Genevieve Neal-Perry, Jelena Pavlovic, John Randolph, Gerson Weiss, Hsiang-Yu Chen, Bill Lasley
Context: Menstrual cycle hormone patterns in women approaching menopause are inadequately studied. Objective: To describe day-to-day menstrual cycle hormones in women as they approach menopause from the Study of Women's Health Across the Nation (SWAN) Daily Hormone Study (DHS). Design: DHS enrollees collected daily urine for one entire menstrual cycle or up to 50 days, whichever came first, annually, up to the final menstrual period (FMP) or for up to 10 years...
March 22, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28355479/a-general-approach-to-test-for-interaction-among-mixtures-of-insecticidal-proteins-which-target-different-orders-of-insect-pests
#12
Gerson Graser, Frederick S Walters, Andrea Burns, Alaina Sauve, Alan Raybould
A shift toward transgenic crops which produce combinations of insecticidal proteins has increased the interest (Syngenta Seeds, Inc., Minnetonka, MN) in studying the potential for interactions amongst those proteins. We present a general testing method which accommodates proteins with nonoverlapping spectrums of activity. Our sequential testing approach first investigates groups of the proteins with overlapping activity; e.g., proteins active against Lepidoptera or Coleoptera, respectively. The Colby method is used to test for interactions within each respective group...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28349553/unilateral-ovarian-absence-in-a-black-headed-squirrel-monkey-saimiri-vanzolinii-ayres-1985-a-threatened-neotropical-primate-species
#13
Gerson P Lopes, Adriel B Brito, Regiane R Santos, Sheyla F S Domingues, Fernanda P Paim, Helder L Queiroz
Ovarian agenesis is an unusual anomaly with traumatic or congenital origin. In the present case report, we describe our findings in a senile S. vanzolinii female. As this neotropical primate species is listed as vulnerable, with limited geographic distribution in the Brazilian Amazonia, ovarian agenesis may be an important finding to be reported.
March 27, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28334780/eif4a3-deficient-human-ipscs-and-mouse-models-demonstrate-neural-crest-defects-that-underlie-richieri-costa-pereira-syndrome
#14
Emily E Miller, Gerson S Kobayashi, Camila M Musso, Miranda Allen, Felipe A A Ishiy, Luiz C de Caires Junior, Ernesto S G Guimarães, Karina Griesi-Oliveira, Roseli M Zechi-Ceide, Antonio Richieri-Costa, Debora R Bertola, Maria Rita Passos-Bueno, Debra L Silver
Biallelic loss-of-function mutations in the RNA binding protein EIF4A3 cause Richieri-Costa-Pereira syndrome (RCPS), an autosomal recessive condition mainly characterized by craniofacial and limb malformations. However, the pathogenic cellular mechanisms responsible for this syndrome are entirely unknown. Here we used two complementary approaches, patient-derived induced pluripotent stem cells (iPSCs) and conditional Eif4a3 mouse models, to demonstrate that defective Neural Crest Cell (NCC) development explains RCPS craniofacial abnormalities...
March 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28330524/rapid-simultaneous-separation-of-four-oral-antidiabetic-drugs-and-quantitative-determination-of-glibenclamide-using-conventional-and-fused-core-silica-columns
#15
Laura Maria Fontes Prado Moraes, Gerson Antônio Pianetti, Isabela da Costa César, Christian Fernandes
Diabetes mellitus is a chronic disease with high and growing prevalence worldwide. Therefore, the development of fast and efficient methods for the QC of antidiabetic drugs is of fundamental importance. Two ultra-fast methods, using a conventional (C18 100 × 2.1 mm, 5 μm fully porous particle) column or a fused-core (C18 100 × 2.1 mm, 2.7 μm fused-core particle) column, were developed for the simultaneous determination of four antidiabetic drugs (chlorpropamide, glibenclamide, gliclazide, and glimepiride)...
February 15, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28327868/resveratrol-treatment-normalizes-the-endothelial-function-and-blood-pressure-in-ovariectomized-rats
#16
Victor Fabricio, Jorge Camargo Oishi, Bruna Gabriele Biffe, Leandro Dias Gonçalves Ruffoni, Karina Ana da Silva, Keico Okino Nonaka, Gerson Jhonatan Rodrigues
Background: Despite knowing that resveratrol has effects on blood vessels, blood pressure and that phytostrogens can also improve the endothelium-dependent relaxation/vasodilation, there are no reports of reveratrol's direct effect on the endothelial function and blood pressure of animals with estrogen deficit (mimicking post-menopausal increased blood pressure). Objective: To verify the effect of two different periods of preventive treatment with resveratrol on blood pressure and endothelial function in ovariectomized young adult rats...
February 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28300923/paramedian-forehead-flap-combined-with-hinge-flap-for-nasal-tip-reconstruction
#17
Felipe Bochnia Cerci, Gerson Dellatorre
The paramedian forehead flap is a great option for restoration of complex nasal defects. For full-thickness defects, it may be used alone or in combination with other methods. We present a patient with a basal cell carcinoma on the distal nose treated by Mohs micrographic surgery, and a resulting full-thickness defect repaired with paramedian forehead flap combined with a hinge flap. For optimal results with the paramedian forehead flap, adequate surgical planning, patient orientation and meticulous surgical technique are imperative...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28286212/lingual-tuberculosis-in-an-hiv-aids-patient
#18
José Y Rodríguez, Gerson J Rodríguez, Carlos A Álvarez-Moreno
No abstract text is available yet for this article.
March 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28272251/tensiomyography-sonoelastography-and-mechanosensitivity-differences-between-active-latent-and-control-low-back-myofascial-trigger-points-a-cross-sectional-study
#19
César Calvo-Lobo, Ignacio Diez-Vega, Beatriz Martínez-Pascual, Silvia Fernández-Martínez, Mónica de la Cueva-Reguera, Gerson Garrosa-Martín, David Rodríguez-Sanz
The myofascial pain syndrome (MPS) is considered the most common musculoskeletal condition. The lumbopelvic pain (LPP) is established as one of the most prevalent musculoskeletal disorders. Nevertheless, previous research has not yet studied the contractibility changes by tensiomyography between myofascial trigger point (MTrP) types and normal tissue. Therefore, the aim of this study was to determine the tensiomyography, sonoelastography, and pressure pain threshold (PPT) differences between the palpation area of active and latent MTrPs with regards to control points in the lumbar erector spinae muscles of subjects with LPP...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28246349/pediatric-hospital-medicine-a-proposed-new-subspecialty
#20
Douglas J Barrett, Gail A McGuinness, Christopher A Cunha, S Jean Emans, William T Gerson, Mary F Hazinski, George Lister, Karen F Murray, Joseph W St Geme, Patricia N Whitley-Williams
Over the past 20 years, hospitalists have emerged as a distinct group of pediatric practitioners. In August of 2014, the American Board of Pediatrics (ABP) received a petition to consider recommending that pediatric hospital medicine (PHM) be recognized as a distinct new subspecialty. PHM as a formal subspecialty raises important considerations related to: (1) quality, cost, and access to pediatric health care; (2) current pediatric residency training; (3) the evolving body of knowledge in pediatrics; and (4) the impact on both primary care generalists and existing subspecialists...
March 2017: Pediatrics
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