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https://www.readbyqxmd.com/read/28334780/eif4a3-deficient-human-ipscs-and-mouse-models-demonstrate-neural-crest-defects-that-underlie-richieri-costa-pereira-syndrome
#1
Emily E Miller, Gerson S Kobayashi, Camila M Musso, Miranda Allen, Felipe A A Ishiy, Luiz C de Caires Junior, Ernesto S G Guimarães, Karina Griesi-Oliveira, Roseli M Zechi-Ceide, Antonio Richieri-Costa, Debora R Bertola, Maria Rita Passos-Bueno, Debra L Silver
Biallelic loss-of-function mutations in the RNA binding protein EIF4A3 cause Richieri-Costa-Pereira syndrome (RCPS), an autosomal recessive condition mainly characterized by craniofacial and limb malformations. However, the pathogenic cellular mechanisms responsible for this syndrome are entirely unknown. Here we used two complementary approaches, patient-derived induced pluripotent stem cells (iPSCs) and conditional Eif4a3 mouse models, to demonstrate that defective Neural Crest Cell (NCC) development explains RCPS craniofacial abnormalities...
March 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28330524/rapid-simultaneous-separation-of-four-oral-antidiabetic-drugs-and-quantitative-determination-of-glibenclamide-using-conventional-and-fused-core-silica-columns
#2
Laura Maria Fontes Prado Moraes, Gerson Antônio Pianetti, Isabela da Costa César, Christian Fernandes
Diabetes mellitus is a chronic disease with high and growing prevalence worldwide. Therefore, the development of fast and efficient methods for the QC of antidiabetic drugs is of fundamental importance. Two ultra-fast methods, using a conventional (C18 100 × 2.1 mm, 5 μm fully porous particle) column or a fused-core (C18 100 × 2.1 mm, 2.7 μm fused-core particle) column, were developed for the simultaneous determination of four antidiabetic drugs (chlorpropamide, glibenclamide, gliclazide, and glimepiride)...
February 15, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28327868/resveratrol-treatment-normalizes-the-endothelial-function-and-blood-pressure-in-ovariectomized-rats
#3
Victor Fabricio, Jorge Camargo Oishi, Bruna Gabriele Biffe, Leandro Dias Gonçalves Ruffoni, Karina Ana da Silva, Keico Okino Nonaka, Gerson Jhonatan Rodrigues
Background: Despite knowing that resveratrol has effects on blood vessels, blood pressure and that phytostrogens can also improve the endothelium-dependent relaxation/vasodilation, there are no reports of reveratrol's direct effect on the endothelial function and blood pressure of animals with estrogen deficit (mimicking post-menopausal increased blood pressure). Objective: To verify the effect of two different periods of preventive treatment with resveratrol on blood pressure and endothelial function in ovariectomized young adult rats...
February 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28300923/paramedian-forehead-flap-combined-with-hinge-flap-for-nasal-tip-reconstruction
#4
Felipe Bochnia Cerci, Gerson Dellatorre
The paramedian forehead flap is a great option for restoration of complex nasal defects. For full-thickness defects, it may be used alone or in combination with other methods. We present a patient with a basal cell carcinoma on the distal nose treated by Mohs micrographic surgery, and a resulting full-thickness defect repaired with paramedian forehead flap combined with a hinge flap. For optimal results with the paramedian forehead flap, adequate surgical planning, patient orientation and meticulous surgical technique are imperative...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28286212/lingual-tuberculosis-in-an-hiv-aids-patient
#5
José Y Rodríguez, Gerson J Rodríguez, Carlos A Álvarez-Moreno
No abstract text is available yet for this article.
March 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28272251/tensiomyography-sonoelastography-and-mechanosensitivity-differences-between-active-latent-and-control-low-back-myofascial-trigger-points-a-cross-sectional-study
#6
César Calvo-Lobo, Ignacio Diez-Vega, Beatriz Martínez-Pascual, Silvia Fernández-Martínez, Mónica de la Cueva-Reguera, Gerson Garrosa-Martín, David Rodríguez-Sanz
The myofascial pain syndrome (MPS) is considered the most common musculoskeletal condition. The lumbopelvic pain (LPP) is established as one of the most prevalent musculoskeletal disorders. Nevertheless, previous research has not yet studied the contractibility changes by tensiomyography between myofascial trigger point (MTrP) types and normal tissue. Therefore, the aim of this study was to determine the tensiomyography, sonoelastography, and pressure pain threshold (PPT) differences between the palpation area of active and latent MTrPs with regards to control points in the lumbar erector spinae muscles of subjects with LPP...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28246349/pediatric-hospital-medicine-a-proposed-new-subspecialty
#7
Douglas J Barrett, Gail A McGuinness, Christopher A Cunha, S Jean Emans, William T Gerson, Mary F Hazinski, George Lister, Karen F Murray, Joseph W St Geme, Patricia N Whitley-Williams
Over the past 20 years, hospitalists have emerged as a distinct group of pediatric practitioners. In August of 2014, the American Board of Pediatrics (ABP) received a petition to consider recommending that pediatric hospital medicine (PHM) be recognized as a distinct new subspecialty. PHM as a formal subspecialty raises important considerations related to: (1) quality, cost, and access to pediatric health care; (2) current pediatric residency training; (3) the evolving body of knowledge in pediatrics; and (4) the impact on both primary care generalists and existing subspecialists...
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28238271/clozapine-treatment-for-cabergoline-induced-psychosis-in-a-patient-with-a-giant-prolactinoma
#8
Rodrigo Pérez-Esparza, Carlos Alberto Rojas-Guerrero, Gerson Geovany Andino-Rios, Patricia Arias-Garro, Jesús Ramírez-Bermúdez, Lesly Portocarrero-Ortiz
No abstract text is available yet for this article.
February 27, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28237339/embryo-production-in-heifers-with-low-or-high-dry-matter-intake-submitted-to-superovulation
#9
Marcos R Mollo, Pedro L J Monteiro, Ricardo S Surjus, Aline C Martins, Alexandre F Ramos, Gerson B Mourão, Luiz H D Carrijo, Gláucio Lopes, Rodolfo Rumpf, Milo C Wiltbank, Roberto Sartori
This study investigated the influence of feed intake on superovulatory response and embryo production of Nelore heifers. Pubertal heifers were kept in a feedlot and were submitted to the same diets, but with different levels of feed consumption: High (1.7 M; n = 20) or Low (0.7 M; n = 19) feed intake. Heifers in the 1.7 M treatment consumed 170% (2.6% of body weight [BW] in dry matter) and the 0.7 M heifers ate 70% (1.1% of BW in dry matter) of a maintenance diet. After 7 wk on these diets, heifers were treated with eight decreasing doses of follicle-stimulating hormone (FSH) given every 12 h, totaling 133 mg Folltropin (Folltropin-V; Bioniche Animal Health, Canada) per heifer...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28225918/the-aplication-of-cyanoacrilate-surgical-glue-on-skin-suture-in-rats
#10
João Ilgenfritz, Ricardo Dutra Aydos, Iandara Schettert Silva, Rondon Tosta Ramalho, João Ilgenfritz, Gerson Gattats Orro de Campos, Ricardo Kenithi Nakamura, Danilo M Zanello Guerisoli, Wilson de Barros Cantero
Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study...
January 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28222139/leprosy-reactions-the-predictive-value-of-mycobacterium-leprae-specific-serology-evaluated-in-a-brazilian-cohort-of-leprosy-patients-u-mdt-ct-br
#11
Emerith Mayra Hungria, Samira Bührer-Sékula, Regiane Morillas de Oliveira, Lúcio Cartaxo Aderaldo, Araci de Andrade Pontes, Rossilene Cruz, Heitor de Sá Gonçalves, Maria Lúcia Fernandes Penna, Gerson Oliveira Penna, Mariane Martins de Araújo Stefani
BACKGROUND: Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps and deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort of patients enrolled at the Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil/U-MDT/CT-BR is suitable to evaluate its prognostic value for the development of reactions. METHODOLOGY: IgM and IgG antibody responses to PGL-I, LID-1, ND-O-LID were evaluated by ELISA in 452 reaction-free leprosy patients at diagnosis, enrolled and monitored for the development of leprosy reactions during a total person-time of 780,930 person-days, i...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28221700/multikinase-inhibitors-sorafenib-and-sunitinib-as-radiosensitizers-in-head-and-neck-cancer-cell-lines
#12
Annette Affolter, Gerson Samosny, Anne-Sophie Heimes, Johanna Schneider, Wilko Weichert, Albrecht Stenzinger, Katharina Sommer, Alexandra Jensen, Arnulf Mayer, Walburgis Brenner, Wolf J Mann, Jürgen Brieger
BACKGROUND: Radioresistance is a common feature of head and neck squamous cell carcinoma (HNSCC). We previously showed that the irradiation- activated vascular endothelial growth factor (VEGF)-extracellular signal-regulated kinase (ERK)-axis is fundamental for the survival of resistant tumors. In this study, we examined if treatment with potent multikinase (MK) inhibitors, sorafenib and sunitinib, could radiosensitize tumor cells. METHODS: Cultured HNSCC cell lines were treated with inhibitors and subsequently irradiated...
February 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/28199478/evaluation-of-o6-benzylguanine-potentiated-topical-carmustine-for-mycosis-fungoides-a-phase-1-2-clinical-trial
#13
Joselin D Tacastacas, Derek V Chan, Sean Carlson, Stanton L Gerson, Afshin Dowlati, Pingfu Fu, Kurt Lu, Sarah Groft, Julie Rosenjack, Kord Honda, Thomas McCormick, Kevin D Cooper
Importance: In a phase 1 trial, single-dose O6-benzylguanine with topical carmustine for patients with early stage (stage IA through stage IIA) cutaneous T-cell lymphoma, mycosis fungoides (MF) type, resulted in clinical responses proportional to inhibition of O6-alkylguanine DNA alkyltransferase activity, but a maximum tolerated dose (MTD) was not reached. Objective: To determine whether dose escalation of carmustine in combination with dual-dose O6-benzylguanine to prolong alkyltransferase inhibition could reach an MTD...
February 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28193891/mapping-evaporative-water-loss-in-desert-passerines-reveals-an-expanding-threat-of-lethal-dehydration
#14
Thomas P Albright, Denis Mutiibwa, Alexander R Gerson, Eric Krabbe Smith, William A Talbot, Jacqueline J O'Neill, Andrew E McKechnie, Blair O Wolf
Extreme high environmental temperatures produce a variety of consequences for wildlife, including mass die-offs. Heat waves are increasing in frequency, intensity, and extent, and are projected to increase further under climate change. However, the spatial and temporal dynamics of die-off risk are poorly understood. Here, we examine the effects of heat waves on evaporative water loss (EWL) and survival in five desert passerine birds across the southwestern United States using a combination of physiological data, mechanistically informed models, and hourly geospatial temperature data...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28185233/sympathetic-drive-stimulating-diastolic-dysfunction
#15
EDITORIAL
Saad S Ahmad, Myron C Gerson
Diastolic heart failure accounts for half of the heart failure population and its pathophysiology remains an area of active research. The renin angiotensin and aldosterone axis has been the focus of clinical trials to treat patients with heart failure with preserved ejection fraction, however with limited yield in terms of clinical success. Sympathetic activity has been considered a plausible cause for the molecular changes that lead to diastolic dysfunction. Based on this understanding the study by Gimelli et al uses MIBG to evaluate for association between diastolic dysfunction and sympathetic denervation...
February 9, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28181508/genome-wide-association-study-for-performance-traits-in-chickens-using-genotype-by-sequencing-approach
#16
Fábio Pértille, Gabriel Costa Monteiro Moreira, Ricardo Zanella, José de Ribamar da Silva Nunes, Clarissa Boschiero, Gregori Alberto Rovadoscki, Gerson Barreto Mourão, Mônica Corrêa Ledur, Luiz Lehmann Coutinho
Performance traits are economically important and are targets for selection in breeding programs, especially in the poultry industry. To identify regions on the chicken genome associated with performance traits, different genomic approaches have been applied in the last years. The aim of this study was the application of CornellGBS approach (134,528 SNPs generated from a PstI restriction enzyme) on Genome-Wide Association Studies (GWAS) in an outbred F2 chicken population. We have validated 91.7% of these 134,528 SNPs after imputation of missed genotypes...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28177746/preliminary-safety-analysis-of-high-intensity-interval-training-hiit-in-persons-with-chronic-stroke
#17
Daniel L Carl, Pierce Boyne, Bradley Rockwell, Myron Gerson, Jane Khoury, Brett Kissela, Kari Dunning
The purpose of this study was to assess safety via electrocardiographic (ECG), blood pressure (BP), heart rate (HR), and orthopedic responses to 3 different high-intensity interval training (HIIT) protocols in persons with stroke. Eighteen participants (10 male; 61.9 + 8.3 years of age; 5.8 + 4.2 years poststroke) completed a symptom-limited graded exercise test (GXT) with ECG monitoring to screen for eligibility and determine HR peak. The 3 HIIT protocols involved repeated 30 s bursts of treadmill walking at maximum speed alternated with rest periods of 30 s (P30), 1 min (P60), or 2 min (P120)...
March 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28175496/141%C3%A2-phase-i-trial-of-genetically-modified-hematopoietic-progenitor-cells-facilitate-bone-marrow-chemoprotection-and-enabling-tmz-o6bg-dose-escalation-resulting-in-improved-survival
#18
Andrew E Sloan, Hua Fung, Jane Reese, Lisa R Rogers, Christopher Murphay, Hillard Lazrus, Boro Dropulic, Stan L Gerson
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28167609/people
#19
(no author information available yet)
Steven K. Libutti, MD; David A. Tuveson, MD, PhD; and Stanton L. Gerson, MD, are featured.
February 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28164651/anti-desmoglein-1-and-3-autoantibody-levels-in-endemic-pemphigus-foliaceus-and-pemphigus-vulgaris-from-brazil
#20
Liana A Oliveira, Alfredo Marquart-Filho, Gerson Trevilato, Rodolfo P Timoteo, Maira Mukai, Ana M F Roselino, Maria L Petzl-Erler
BACKGROUND: Pemphigus is a group of autoimmune blistering diseases of which the major forms are pemphigus foliaceus (PF) and vulgaris (PV). In Brazil, PF occurs in an endemic form also known as fogo selvagem. The main autoantibody in PF is against desmoglein 1 (DSG1), while in PV the main antibody is anti-desmoglein 3 (DSG3), but often anti-DSG1 is also present. The aim of the present study was to analyze the levels of anti-DSG1 and antiDSG3 autoantibodies in Brazilian PF and PV patients, considering different stages of the disease for PF patients and comparing these levels to those of healthy individuals living in and outside the endemic regions...
July 1, 2016: Clinical Laboratory
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