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https://www.readbyqxmd.com/read/28926513/pharmacokinetics-and-safety-profile-of-single-dose-administration-of-an-estrogen-receptor-%C3%AE-selective-phytoestrogenic-phytoserm-formulation-in-perimenopausal-and-postmenopausal-women
#1
Gerson Hernandez, Liqin Zhao, Adrian A Franke, Yu-Ling Chen, Wendy J Mack, Roberta D Brinton, Lon S Schneider
OBJECTIVE: Selected estrogen receptor β-selective phytoestrogen (phytoSERM), a preparation of genistein, daidzein, and S-equol, has an 83-fold selective affinity for estrogen receptor (ER) β, and may promote neuronal survival and estrogenic mechanisms in the brain without exerting feminizing activity in the periphery. The aim of this study was to assess the safety, tolerability, and single-dose pharmacokinetics of the phytoSERM formulation in perimenopausal and postmenopausal women...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28917339/in-memoriam-lauren-battat-gerson-md-ms
#2
EDITORIAL
George Triadafilopoulos, Glenn Eisen, Michael B Wallace
No abstract text is available yet for this article.
October 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28902845/clinical-and-epidemiologic-characteristics-of-dengue-and-other-etiologic-agents-among-patients-with-acute-febrile-illness-puerto-rico-2012-2015
#3
Kay M Tomashek, Olga D Lorenzi, Doris A Andújar-Pérez, Brenda C Torres-Velásquez, Elizabeth A Hunsperger, Jorge Luis Munoz-Jordan, Janice Perez-Padilla, Aidsa Rivera, Gladys E Gonzalez-Zeno, Tyler M Sharp, Renee L Galloway, Mindy Glass Elrod, Demetrius L Mathis, M Steven Oberste, W Allan Nix, Elizabeth Henderson, Jennifer McQuiston, Joseph Singleton, Cecilia Kato, Carlos García Gubern, William Santiago-Rivera, Jesús Cruz-Correa, Robert Muns-Sosa, Juan D Ortiz-Rivera, Gerson Jiménez, Ivonne E Galarza, Kalanthe Horiuchi, Harold S Margolis, Luisa I Alvarado
Identifying etiologies of acute febrile illnesses (AFI) is challenging due to non-specific presentation and limited availability of diagnostics. Prospective AFI studies provide a methodology to describe the syndrome by age and etiology, findings that can be used to develop case definitions and multiplexed diagnostics to optimize management. We conducted a 3-year prospective AFI study in Puerto Rico. Patients with fever ≤7 days were offered enrollment, and clinical data and specimens were collected at enrollment and upon discharge or follow-up...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28887601/is-there-a-role-for-epithelial-mesenchymal-transition-in-adrenocortical-tumors
#4
Daniel Bulzico, Paulo Antônio Silvestre de Faria, Camila Bravo Maia, Marcela Pessoa de Paula, Davi Coe Torres, Gerson Moura Ferreira, Bruno Ricardo Barreto Pires, Rocio Hassan, Eliana Abdelhay, Mario Vaisman, Leonardo Vieira Neto
PURPOSE: Epithelial-mesenchymal transition (EMT) is a biological dynamic process by which epithelial cells lose their epithelial phenotype and acquire mesenchymal invasive and migratory characteristics. This has been postulated as an essential step during cancer progression and metastasis. Although this is well described in other tumors, the role of EMT in adrenocortical tumors (ACT) has yet to be addressed. METHODS: The aim of this study was to evaluate the expression of EMT markers e-cadherin, vimentin, and fibronectin, along with EMT-transcription factors (EMT-TFs), TWIST1, SIP1, and SNAIL in 24 adrenocortical carcinoma (ACC), 19 adrenocortical adenomas (ACA), 27 childhood-onset adrenocortical tumors (CAT), and 12 normal adrenal glands...
September 8, 2017: Endocrine
https://www.readbyqxmd.com/read/28877561/a-severe-phenotype-of-kennedy-s-disease-associated-with-a-very-large-cag-repeat-expansion
#5
João Lo Madeira, Alexandre Bc Souza, Flavia S Cunha, Rafael L Batista, Nathalia L Gomes, Andresa S Rodrigues, Frederico Mennucci de Haidar Jorge, Gerson Chadi, Dagoberto Callegaro, Berenice B Mendonca, Elaine Mf Costa, Sorahia Domenice
No abstract text is available yet for this article.
September 6, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28876377/crack-cocaine-users-have-less-family-cohesion-than-alcohol-users
#6
Nino C Marchi, Juliana N Scherer, Mayra P Pachado, Luciano S Guimarães, Gerson Siegmund, Melina N de Castro, Silvia Halpern, Daniela Benzano, Maria L Formigoni, Marcelo Cruz, Flavio Pechansky, Felix H Kessler
Objective: Many studies correlate characteristics of family functioning and the development of drug addiction. This study sought to evaluate and compare the family environment styles of two groups of psychoactive substance users: 1) alcohol-only users and 2) crack-cocaine users. Methods: Three hundred and sixty-four users of alcohol, crack-cocaine, and other drugs, recruited from research centers in four Brazilian capitals participated in this study. Subjects were evaluated through the Family Environment Scale and the Addiction Severity Index, 6th version (ASI-6)...
August 30, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28861743/feasibility-and-safety-of-exercise-stress-testing-using-an-anti-gravity-treadmill-with-tc-99m-tetrofosmin-single-photon-emission-computed-tomography-spect-myocardial-perfusion-imaging-a-pilot-non-randomized-controlled-study
#7
Patrick Daly, Regina Kayse, Steven Rudick, Nathan Robbins, Jennifer Scheler, David Harris, Robert O'Donnell, Alok K Dwivedi, Myron C Gerson
BACKGROUND: Exercise is the AHA/ACC guideline-recommended stress modality for myocardial perfusion imaging, but many patients are unable to exercise to target heart rate on a conventional treadmill. We examined the feasibility and safety of stress imaging using an anti-gravity treadmill in patients with perceived poor exercise capacity. METHODS AND RESULTS: 49 patients were recruited for stress testing by anti-gravity treadmill (n = 29) or to a regadenoson control group (n = 20)...
August 31, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28834427/the-formation-of-silicate-stabilised-passivating-layers-on-pyrite-for-reduced-acid-rock-drainage
#8
Rong Fan, Michael Short, Sheng-Jia Zeng, Gujie Qian, Jun Li, Russell Schumann, Nobuyuki Kawashima, Roger St C Smart, Andrea R Gerson
Acid and metalliferous release occurring when sulfide (principally pyrite)-containing rock from mining activities and from some natural environments is exposed to the elements is acknowledged as a major environmental problem. Acid rock drainage (ARD) management is both challenging and costly for operating and legacy mine sites. Current technological solutions are expensive and focused on treating ARD on release rather than preventing it at source. We describe here a viable, practical mechanism for reduced ARD through the formation of silicate-stabilised iron hydroxide surface layers...
August 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28832850/changes-in-commuting-to-work-and-physical-activity-in-the-population-of-three-municipalities-in-the-s%C3%A3-o-paulo-region-in-2000-and-2010
#9
Josivaldo de Souza Lima, Gerson Luis de Moraes Ferrari, Tatiane Kosimenko Ferrari, Timóteo Leandro Araujo, Victor Keihan Rodrigues Matsudo
Objective: To evaluate the changes in commuting to work and physical activity (PA) in the population of three municipalities in the São Paulo region in 2000 and 2010. Methods: Cross-sectional study with a representative sample of 602 adults (62.3% men) carried out in the municipalities of Santo André, São Bernardo do Campo and São Caetano do Sul in 2000 (n = 304; 66.1% men) and 2010 (n = 298; 58.4% men). Physical activity was assessed by the International Physical Activity Questionnaire and participants were classified into active (≥ 150 min/week) and insufficiently active (< 150 min/week)...
April 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28800802/special-considerations-in-the-pediatric-psychiatric-population
#10
REVIEW
Genevieve Santillanes, Ruth S Gerson
Youth with psychiatric and behavioral complaints commonly present to emergency departments (EDs), which often lack dedicated mental health staff. This article addresses techniques EDs can use to better care for children in need of psychiatric assessment and medical clearance, specifically addressing the evaluation of youth with suicidal ideation and coexisting medical and psychiatric needs. The evaluation and management of youth with agitation and aggression are also discussed. The article concludes with a discussion of systems changes needed to truly improve emergency care for psychiatrically ill youth...
September 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28793125/clinical-simulation-with-dramatization-gains-perceived-by-students-and-health-professionals
#11
Elaine Cristina Negri, Alessandra Mazzo, José Carlos Amado Martins, Gerson Alves Pereira, Rodrigo Guimarães Dos Santos Almeida, César Eduardo Pedersoli
Objective: to identify in the literature the gains health students and professionals perceive when using clinical simulation with dramatization resources. Method: integrative literature review, using the method proposed by the Joanna Briggs Institute (JBI). A search was undertaken in the following databases: Latin American and Caribbean Health Sciences Literature, Web of Science, National Library of Medicine, Cumulative Index to Nursing and Allied Health Literature, The Cochrane Library, Scopus, Scientific Electronic Library Online...
August 3, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28793084/-use-of-medicinal-plants-as-home-remedies-in-primary-health-care-in-blumenau-state-of-santa-catarina-brazil
#12
Ana Lúcia Bertarello Zeni, Amanda Varnier Parisotto, Gerson Mattos, Ernani Tiaraju de Santa Helena
An increase in the use of alternative therapeutic practices has been observed in the past decade, especially in medicinal plants, herbal and home remedies, which has been supported by policies within the scope of the Unified Health System (SUS). This study investigated the use of home remedies by users of Primary Health Care in Blumenau, State of Santa Catarina. It is a cross-sectional, observational and epidemiological study, the data for which were obtained via a questionnaire applied to 701 individuals. An unconditional logistic regression model was used to estimate the association between the use of home remedies and socio-demographic and medical care variables...
August 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28793008/geo-environmental-zoning-using-physiographic-compartmentalization-a-proposal-for-supporting-sustainable-decision-making
#13
Claudia V S Corrêa, Fábio A G V Reis, Lucilia C Giordano, Adriano Bressane, Camila J Chaves, Ana Maria C DO Amaral, Hermes D Brito, Gerson A DE Medeiros
The geo-environmental zoning represents an important strategy in the territorial management. However, it requires a logical and structured procedure. Therefore, an approach using physiographic compartmentalization is proposed and applied as case study in a region covered by the topographic maps of São José dos Campos and Jacareí, Brazil. This region has great geological and geomorphological peculiarities, beyond being a place with large human interventions because of its quickly economic growth. The methodology is based on photointerpretation techniques and remote sensing in GIS environment...
August 7, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28793007/ostracoda-and-foraminifera-from-paleocene-olinda-well-para%C3%A3-ba-basin-brazilian-northeast
#14
Enelise K Piovesan, Robbyson M Melo, Fernando M Lopes, Gerson Fauth, Denize S Costa
Paleocene ostracods and planktonic foraminifera from the Maria Farinha Formation, Paraíba Basin, are herein presented. Eleven ostracod species were identified in the genera Cytherella Jones, Cytherelloidea Alexander, Eocytheropteron Alexander, Semicytherura Wagner, Paracosta Siddiqui, Buntonia Howe, Soudanella Apostolescu, Leguminocythereis Howe and, probably, Pataviella Liebau. The planktonic foraminifera are represented by the genera Guembelitria Cushman, Parvularugoglobigerina Hofker, Woodringina Loeblich and Tappan, Heterohelix Ehrenberg, Zeauvigerina Finlay, Muricohedbergella Huber and Leckie, and Praemurica Olsson, Hemleben, Berggren and Liu...
August 7, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28792987/-infant-mortality-according-to-color-or-race-based-on-the-2010-population-census-and-national-health-information-systems-in-brazil
#15
Aline Diniz Rodrigues Caldas, Ricardo Ventura Santos, Gabriel Mendes Borges, Joaquim Gonçalves Valente, Margareth Crisóstomo Portela, Gerson Luiz Marinho
The aim of this study was to investigate infant mortality data according to color or race in Brazil with a focus on indigenous individuals, based on data from the 2010 Population Census and the Brazilian Mortality Information System (SIM) and Brazilian Information System on Live Births (SINASC). In both sources, the infant mortality rate (IMR) for indigenous individuals was the highest of all the various population segments. Although the census data indicate inequalities by color or race, the infant mortality rates for indigenous and black individuals were lower than those based on data from SIM/SINASC...
August 7, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28781207/testing-of-an-oral-dosing-technique-for-double-crested-cormorants-phalacocorax-auritus-laughing-gulls-leucophaeus-atricilla-homing-pigeons-columba-livia-and-western-sandpipers-calidris-mauri-with-artificially-weather-mc252-oil
#16
K M Dean, D Cacela, M W Carney, F L Cunningham, C Ellis, A R Gerson, C G Guglielmo, K C Hanson-Dorr, K E Harr, K A Healy, K E Horak, J P Isanhart, L V Kennedy, J E Link, I Lipton, A K McFadden, J K Moye, C R Perez, C A Pritsos, K L Pritsos, T Muthumalage, S A Shriner, S J Bursian
Scoping studies were designed to determine if double-crested cormorants (Phalacocorax auritus), laughing gulls (Leucophaues atricilla), homing pigeons (Columba livia) and western sandpipers (Calidris mauri) that were gavaged with a mixture of artificially weathered MC252 oil and food for either a single day or 4-5 consecutive days showed signs of oil toxicity. Where volume allowed, samples were collected for hematology, plasma protein electrophoresis, clinical chemistry and electrolytes, oxidative stress and organ weigh changes...
August 3, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28767666/mismatch-repair-deficient-hematopoietic-stem-cells-are-preleukemic-stem-cells
#17
Yulan Qing, Stanton L Gerson
Whereas transformation events in hematopoietic malignancies may occur at different developmental stages, the initial mutation originates in hematopoietic stem cells (HSCs), creating a preleukemic stem cell (PLSC). Subsequent mutations at either stem cell or progenitor cell levels transform the PLSC into lymphoma/leukemia initiating cells (LIC). Thymic lymphomas have been thought to develop from developing thymocytes. T cell progenitors are generated from HSCs in the bone marrow (BM), but maturation and proliferation of T cells as well as T-lymphomagenesis depends on both regulatory mechanisms and microenvironment within the thymus...
2017: PloS One
https://www.readbyqxmd.com/read/28760832/avian-thermoregulation-in-the-heat-evaporative-cooling-capacity-of-arid-zone-caprimulgiforms-from-two-continents
#18
William A Talbot, Todd J McWhorter, Alexander R Gerson, Andrew E McKechnie, Blair O Wolf
Birds in the order Caprimulgiformes (nightjars and allies) have a remarkable capacity for thermoregulation over a wide range of environmental temperatures, exhibiting pronounced heterothermy in cool conditions and extreme heat tolerance at high environmental temperatures. We measured thermoregulatory responses to acute heat stress in three species of caprimulgiforms that nest in areas of extreme heat and aridity, the common poorwill (Phalaenoptilus nuttallii: Caprimulgidae) and lesser nighthawk (Chordeiles acutipennis: Caprimulgidae) in the Sonoran Desert of Arizona, and the Australian owlet-nightjar (Aegotheles cristatus: Aegothelidae) in the mallee woodlands of South Australia...
July 31, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28760566/3-d-virtual-reconstruction-of-a-large-amniocele-with-protrusion-of-legs-and-umbilical-cord-following-asymptomatic-uterine-rupture
#19
Renato Augusto Moreira de Sá, Valeria Pereira de Moraes, Marianne Cecília da Costa Soares, Heron Werner, Gerson Ribeiro, Jorge Lopes, Edward Araujo Júnior
BACKGROUND: Complete uterine rupture is a rare and severe intrapartum complication with high rates of maternal and fetal mortality. Asymptomatic uterine rupture is a very rare condition with one unique previous case described in the literature. Three-dimensional virtual models allow an immersive virtual reality of maternal-fetal structures with better understanding by the parents and the medical team. CASE: We demonstrate a case of asymptomatic rupture uterine with a large amniocele and protruded legs and umbilical cord at 28 weeks of gestation by using a 3-D virtual model from ultrasound scan data...
July 28, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28757316/increased-detection-of-barrett-s-esophagus-associated-neoplasia-using-wide-area-trans-epithelial-sampling-a-multicenter-prospective-randomized-trial
#20
Prashanth R Vennalaganti, Vivek Kaul, Kenneth K Wang, Gary W Falk, Nicholas J Shaheen, Anthony Infantolino, David A Johnson, Glenn Eisen, Lauren B Gerson, Michael S Smith, Prasad G Iyer, Charles J Lightdale, Felice Schnoll-Sussman, Neil Gupta, Seth A Gross, Julian Abrams, Gregory B Haber, Ram Chuttani, Douglas K Pleskow, Shivangi Kothari, John R Goldblum, Yaxia Zhang, Prateek Sharma
BACKGROUND AND AIMS: Wide-area transepithelial sampling (WATS) with computer-assisted 3-dimensional analysis is a sampling technique that combines abrasive brushing of the Barrett's esophagus (BE) mucosa followed by neural network analysis to highlight abnormal-appearing cells. METHODS: We performed a randomized trial of referral BE patients undergoing surveillance at 16 medical centers. Subjects received either biopsy followed by WATS, or vice versa. The primary outcome was rate of detection of HGD/EAC using WATS in conjunction with biopsy compared with biopsy alone using standard histopathologic criteria...
July 27, 2017: Gastrointestinal Endoscopy
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