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https://www.readbyqxmd.com/read/28087167/lingering-questions-about-enhancer-rna-and-enhancer-transcription-coupled-genomic-instability
#1
REVIEW
Gerson Rothschild, Uttiya Basu
Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote collisions of transcription complexes with replisomes...
January 10, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28079402/sexual-dysfunction-in-premenopausal-women-could-be-related-to-hormonal-profile
#2
Fabiene Bernardes Castro Vale, Bruna Barbosa Coimbra, Gerson Pereira Lopes, Selmo Geber
Female sexual dysfunction (FSD) is a public health problem that affects women's quality of life. Although the relationship between some hormones and the FSD has been described, it is not well established for all hormones. Therefore, the aim of our study was to evaluate the association between hormonal dysfunction and sexual dysfunction in premenopausal women. We performed a cross-sectional study with 60 patients with regular menstrual cycles, with age ranging from 18 to 44 years, with previous diagnosis of FSD...
January 12, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28069475/retention-associated-with-video-capsule-endoscopy-systematic-review-and-meta-analysis
#3
REVIEW
Mona Rezapour, Chidi Amadi, Lauren Gerson
BACKGROUND: Video capsule endoscopy (VCE) has become a major diagnostic tool for small-bowel evaluation. However, retention of the video capsule endoscope remains a major concern. METHODS: We performed a systematic review of VCE retention rates using Pubmed and SCOPUS (1995-2015). We included studies that enrolled at least 10 subjects, included VCE retention rates, and separated retention rates by indication. We used Comprehensive Meta-Analysis (Version 3.0) to calculate pooled prevalence rates with 95% confidence intervals and assessed heterogeneity using Cochran's Q statistic...
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28060794/postnatal-human-enteric-neuronal-progenitors-can-migrate-differentiate-and-proliferate-in-embryonic-and-postnatal-aganglionic-gut-environments
#4
Lily S Cheng, Ryo Hotta, Hannah K Graham, Jaime Belkind-Gerson, Nandor Nagy, Allan M Goldstein
BACKGROUND: Enteric neural stem/progenitor cells (ENSCs) offer an innovative approach to treating Hirschsprung disease (HSCR) and other enteric neuropathies. However, postnatal-derived human ENSCs have not been thoroughly characterized and their behavior in the embryonic and postnatal intestinal environment is unknown. METHODS: ENSCs were isolated from the intestines of 25 patients undergoing bowel resection, including 7 children with HSCR. Neuronal differentiation and proliferation of ENSCs from submucosal and myenteric plexuses from patients with and without HSCR were characterized...
January 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28036310/comparison-of-hrm-analysis-and-three-rep-pcr-genomic-fingerprint-methods-for-rapid-typing-of-mrsa-at-a-brazilian-hospital
#5
Giovana Carolina Bodnar, Heloísa Moreira Martins, Caio Ferreira De Oliveira, Alexandre Tadachi Morey, Eliandro Reis Tavares, Juscélio Donizete Cardoso, Marcia Regina Eches Perugini, Lucy Megumi Yamauchi Lioni, Sueli Fumie Yamada-Ogatta, Renata Katsuko Takayama Kobayashi, Gerson Nakazato
INTRODUCTION: Infections caused by multidrug-resistant bacteria are increasingly common and represent a serious problem for public health. Staphylococcus aureus is one of the major agents of infections, and methicillin-resistant S. aureus (MRSA) has spread worldwide. The aim of this study was to phenotypically and genotypically characterize 55 MRSAs isolated in the University Hospital of Londrina, Paraná, Brazil, during 2010. METHODOLOGY: Bacterial isolates were characterized based on their antimicrobial susceptibility profile, biofilm production capacity, and staphylococcal chromosome cassette mec (SCCmec) type...
December 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28031968/tooth-tissue-engineering-tooth-decellularization-for-natural-scaffold
#6
Luciana Aparecida de Sousa Iwamoto, Monica Talarico Duailibi, Gerson Yoshinobu Iwamoto, Yara Juliano, Michel Silvio Duailibi, Francisco André Ossamu Tanaka, Silvio Eduardo Duailibi
AIM: Tissue engineering is a multidisciplinary science that aims to produce replacement organs and biological substitutes. One of the techniques involves decellularizing a biological organ without altering its structure. One challenge is how to demonstrate which method would be better for this process. METHODOLOGY: Fifty premolar teeth were divided into five groups: G1 (control): solution of 10% formaldehyde; G2: phosphate buffer saline (PBS), 28 g of tetrasodium ethylenediaminetetraacetic (EDTA), sodium hypochlorite 2...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28025364/-managing-the-placebo-effect-the-single-blind-placebo-lead-in-response-in-two-pain-models
#7
R Norman Harden, Meryem Saracoglu, Sara Connolly, Amy Kirsling, Kelly Comstock, Katherine Khazey, Trevor Gerson, John Burns
OBJECTIVE: "Placebo effects" in analgesic medication trials for chronic pain are pervasive; however, little is known regarding mechanisms or factors that may influence the presence or magnitude of these effects. Our objective is to consider elements of the placebo response in the context of two pain models using a "single-blind placebo lead-in" design (SBPLI). METHODS: As part of two pilot drug trials using knee osteoarthritis (KOA) and non-radicular low back pain (LBP) subjects, SBPLI protocols were conducted...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28011226/metabolic-profiling-of-human-endothelial-cells-during-autophagy-assessed-in-a-biomimetic-microfluidic-device-model
#8
Cezar Rangel Pestana, Ana Carolina Urbaczek, Juliana Vieira Alberici, Gerson Jhonatan Rodrigues, Emanuel Carrilho
AIMS: Autophagy is critical to endothelial function. We explored the effects of autophagy induced by serum deprivation on Human Umbilical Vascular Endothelial Cells (HUVEC) metabolome profile and its inhibition by the antimalarial drug chloroquine (CLQ) using a microfluidic biomimetic model MAIN METHODS: The metabolites secreted by HUVEC into the circulating microfluidics were determined by liquid chromatography mass spectrometry (LC-MS) and further analyzed using Metaboanalyst 3.0 multivariate and pathway analysis tools...
December 20, 2016: Life Sciences
https://www.readbyqxmd.com/read/28004777/gene-expression-differences-in-longissimus-muscle-of-nelore-steers-genetically-divergent-for-residual-feed-intake
#9
Polyana C Tizioto, Luiz L Coutinho, Priscila S N Oliveira, Aline S M Cesar, Wellison J S Diniz, Andressa O Lima, Marina I Rocha, Jared E Decker, Robert D Schnabel, Gerson B Mourão, Rymer R Tullio, Adhemar Zerlotini, Jeremy F Taylor, Luciana C A Regitano
Residual feed intake (RFI), a measure of feed efficiency (FE), is defined as the difference between the observed and the predictable feed intake considering size and growth of the animal. It is extremely important to beef production systems due to its impact on the allocation of land areas to alternative agricultural production, animal methane emissions, food demand and cost of production. Global differential gene expression analysis between high and low RFI groups (HRFI and LRFI: less and more efficient, respectively) revealed 73 differentially expressed (DE) annotated genes in Longissimus thoracis (LT) muscle of Nelore steers...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27978769/genetic-analysis-of-patients-with-familial-and-sporadic-amyotrophic-lateral-sclerosis-in-a-brazilian-research-center
#10
Gerson Chadi, Jessica Ruivo Maximino, Frederico Mennucci de Haidar Jorge, FabríCIO Castro dE Borba, Joyce Meire Gilio, Dagoberto Callegaro, Camila GalvãO Lopes, Samantha Nakamura Dos Santos, Gabriela Natania Sales Rebelo
OBJECTIVE: To investigate gene mutations in familial form (FALS) and sporadic form (SALS) of amyotrophic lateral sclerosis (ALS) in a highly miscegenated population. METHODS: Frequencies of mutations in the C9orfF72, TARDBP, SOD1, FUS and VAPB genes were investigated in a cohort of FALS (n = 39) and SALS (n = 189) subjects from the Research Centre of the University of São Paulo School of Medicine. All patients were subjected to C9orf72 and TARDBP analyses...
December 15, 2016: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/27975249/tau-oligomers-as-pathogenic-seeds-preparation-and-propagation-in-vitro-and-in-vivo
#11
Julia E Gerson, Urmi Sengupta, Rakez Kayed
Tau oligomers have been shown to be the main toxic tau species in a number of neurodegenerative disorders. In order to study tau oligomers both in vitro and in vivo, we have established methods for the reliable preparation, isolation, and detection of tau oligomers. Methods for the seeding of tau oligomers, isolation of tau oligomers from tissue, and detection of tau oligomers using tau oligomer-specific antibodies by biochemical and immunohistochemical methods are detailed below.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27940276/maximal-inspiratory-pressure-does-the-choice-of-reference-values-actually-matter
#12
Antenor Rodrigues, Marianne L Da Silva, Danilo C Berton, Gerson Cipriano, Fabio Pitta, Denis E O'Donnell, J Alberto Neder
BACKGROUND: Single-point measurements of maximal inspiratory pressure (MIP) are frequently used to suggest muscle weakness in clinical practice. Although there is a large variability in "mean" predicted MIP depending on the chosen reference values, it remains unclear whether those discrepancies actually impact on the prevalence of weakness, i.e., MIP below the lower limit of normal. METHODS: 1729 subjects (50.1% males, aged 20 to 94) who underwent MIP measurements in a clinical laboratory comprised the study group...
December 8, 2016: Chest
https://www.readbyqxmd.com/read/27919284/can-baseline-ml-flow-test-results-predict-leprosy-reactions-an-investigation-in-a-cohort-of-patients-enrolled-in-the-uniform-multidrug-therapy-clinical-trial-for-leprosy-patients-in-brazil
#13
Emerith Mayra Hungria, Regiane Morillas Oliveira, Gerson Oliveira Penna, Lúcio Cartaxo Aderaldo, Maria Araci de Andrade Pontes, Rossilene Cruz, Heitor de Sá Gonçalves, Maria Lúcia Fernandes Penna, Ligia Regina Franco Sansigolo Kerr, Mariane Martins de Araújo Stefani, Samira Bührer-Sékula
BACKGROUND: The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial. Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR). METHODS: This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers...
December 6, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27916878/burkholderia-contaminans-colonization-from-contaminated-liquid-docusate-colace-in-a-immunocompetent-adult-with-legionnaire-s-disease-infection-control-implications-and-the-potential-role-of-candida-pellucosa
#14
Burke A Cunha, John Gian, Bertamaria Dieguez, Elsa Santos-Cruz, Daniela Matassa, Steve Gerson, Pat Daniels, Carlos Rosales, Rodger P Silletti
Objective:B. contaminans was cultured from respiratory secretions and liquid docusate (Colace) in a Neurosurgical Intensive Care Unit (NICU) patient with community-acquired Legionnaire's disease but not from another bottle given to the patient. Unexpectedly, C. pelliculosa was cultured from two bottles, but not the B. contaminans bottle or respiratory secretions. Methods:B. cepacia, later identified as B. contaminans, was cultured from a bottle of liquid docusate (Colace) dispensed to a non-cystic fibrosis patient...
November 30, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27908523/evaluation-of-the-small-intestine
#15
EDITORIAL
Lauren B Gerson
No abstract text is available yet for this article.
January 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/27908516/small-bowel-bleeding-updated-algorithm-and-outcomes
#16
REVIEW
Lauren B Gerson
Patients previously classified with "obscure gastrointestinal hemorrhage" should now be classified as "suspected small bowel bleeding" according to the 2015 American College of Gastroenterology guidelines. This article provides algorithms for how to manage patients with suspected small bowel bleeding, including utilization of second-look endoscopy and/or colonoscopy, video capsule endoscopy, computed tomographic enterography, magnetic resonance enterography, angiography, and deep enteroscopy.
January 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/27908507/usage-of-air-jigging-for-multi-component-separation-of-construction-and-demolition-waste
#17
Weslei Monteiro Ambrós, Carlos Hoffmann Sampaio, Bogdan Grigore Cazacliu, Gerson Luis Miltzarek, Leonardo R Miranda
The use of air jigging for performing multi-component separation in the treatment of mixed construction and demolition waste was studied. Sorting tests were carried out with mixtures of equal bulk volume of concrete and brick in which fixed quantities of unwanted materials - gypsum, wood and paper - were added. Experimental results have demonstrated the possibility to use air jigging to carry out both the removal of low-density contaminants and the concrete concentration in only one process step. In relation to the removal of contaminants only, the overall performance of jigging process can be comparable with that of commercial air classifiers and automatic sorting systems...
November 28, 2016: Waste Management
https://www.readbyqxmd.com/read/27898197/site-specific-reactivity-of-ethylene-at-distorted-dangling-bond-configurations-on-si-001
#18
Josua Pecher, Gerson Mette, Michael Dürr, Ralf Ewald Tonner
We report differences in adsorption and reaction energetics for ethylene on Si(001) with respect to different dangling bond configurations induced by hydrogen precoverage as obtained via density functional theory calculations. This can help to understand the influence of surface defects and precoverage on the reactivity of organic molecules on semiconductor surfaces in general. Our results show that the reactivity on surface dimers fully enclosed by hydrogen covered atoms is essentially unchanged compared to the clean surface...
November 29, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27889126/identification-of-the-major-yeasts-isolated-from-high-moisture-corn-and-corn-silages-in-the-united-states-using-genetic-and-biochemical-methods
#19
M C Santos, C Golt, R D Joerger, G D Mechor, Gerson B Mourão, L Kung
The objective of this study was to identify species of yeasts in samples of high moisture corn (HMC) and corn silage (CS) collected from farms throughout the United States. Samples were plated and colonies were isolated for identification using DNA analysis. Randomly selected colonies were also identified by fatty acid methyl esters (FAME) and by physiological substrate profiling (ID 32C). For CS, Candida ethanolica, Saccharomyces bulderi, Pichia anomala, Kazachstania unispora, and Saccharomyces cerevisiae were the predominant yeasts...
November 23, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27875996/differences-in-the-skeletal-muscle-transcriptome-profile-associated-with-extreme-values-of-fatty-acids-content
#20
Aline S M Cesar, Luciana C A Regitano, Mirele D Poleti, Sónia C S Andrade, Polyana C Tizioto, Priscila S N Oliveira, Andrezza M Felício, Michele L do Nascimento, Amália S Chaves, Dante P D Lanna, Rymer R Tullio, Renata T Nassu, James E Koltes, Eric Fritz-Waters, Gerson B Mourão, Adhemar Zerlotini-Neto, James M Reecy, Luiz L Coutinho
BACKGROUND: Lipids are a class of molecules that play an important role in cellular structure and metabolism in all cell types. In the last few decades, it has been reported that long-chain fatty acids (FAs) are involved in several biological functions from transcriptional regulation to physiological processes. Several fatty acids have been both positively and negatively implicated in different biological processes in skeletal muscle and other tissues. To gain insight into biological processes associated with fatty acid content in skeletal muscle, the aim of the present study was to identify differentially expressed genes (DEGs) and functional pathways related to gene expression regulation associated with FA content in cattle...
November 22, 2016: BMC Genomics
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