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https://www.readbyqxmd.com/read/28751992/prostatic-like-syndrome-in-a-woman-with-chronic-lymphocytic-leukemia-sequential-kinase-inhibitor-therapy
#1
Diego Velasco-Rodríguez, Miguel Piris-Villaespesa, Carmen Soteras, Ana Vallés, José Antonio García-Marco, José Antonio García-Vela
Chronic lymphocytic leukemia (CLL) is an incurable lymphoproliferative disorder with a heterogeneous genetic and clinical course. Two kinase inhibitors, ibrutinib and idelalisib, have demonstrated achievement of complete and durable remissions in relapse/refractory genetically unselected CLL patients. We present a case of relapsed CLL with extensive disease and hourglass deformity of urinary bladder as a result of the compression of two extraperitoneal paravesical soft tissue bulky masses, with excellent response to sequential kinase inhibitor therapy...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28679490/continuous-monitoring-of-vital-signs-using-wearable-devices-on-the-general-ward-pilot-study
#2
Mariska Weenk, Harry van Goor, Bas Frietman, Lucien Jlpg Engelen, Cornelis Jhm van Laarhoven, Jan Smit, Sebastian Jh Bredie, Tom H van de Belt
BACKGROUND: Measurement of vital signs in hospitalized patients is necessary to assess the clinical situation of the patient. Early warning scores (EWS), such as the modified early warning score (MEWS), are generally calculated 3 times a day, but these may not capture early deterioration. A delay in diagnosing deterioration is associated with increased mortality. Continuous monitoring with wearable devices might detect clinical deterioration at an earlier stage, which allows clinicians to take corrective actions...
July 5, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28504187/transoral-oropharyngeal-resection-classification-proposal-of-the-scorl-working-group
#3
David Virós Porcuna, Francisco Avilés Jurado, Carlos Pollán Guisasola, Rosa Delia Ramírez Ruiz, Jacinto García Lorenzo, Marc Tobed Secall, Isabel Vilaseca González, José Miguel Costa González, Josep Soteras Olle, Francesc Casamitjana Claramunt, Anna Sumarroca Trouboul, Rafael Hijano Esqué, Guillem Viscasillas Pallàs, Manel Mañós Pujol, Miquel Quer Agustí
INTRODUCTION AND GOALS: There has been a very significant increase in the use of minimally invasive surgery has in the last decade. In order to provide a common language after transoral surgery of the oropharynx, a system for classifying resections has been created in this area, regardless of the instrumentation used. METHODS: From the Oncology Working Group of the Catalan Society of Otorhinolaryngology, a proposal for classification based on a topographical division of the different areas of the oropharynx is presented, as also based on the invasion of the related structures according to the anatomical routes of extension of these tumours...
May 11, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28370222/ombitasvir-paritaprevir-ritonavir-dasabuvir%C3%A2-%C3%A2-%C3%A2-ribavirin-is-safe-and-effective-in-hcv-infected-patients-in-a-real-life-cohort-from-latin-america
#4
Manuel Mendizabal, Leila Haddad, Patricia E Gallardo, Alejandro Ferrada, Alejandro A Soza, Raul Adrover, Edmundo Aravena, Juan P Roblero, Jhon Prieto, Claudia Vujacich, Gustavo Romero, Alberto Muñoz, Margarita Anders, Nelia Hernández, Daniel Coccozella, Fernando Gruz, Maria V Reggiardo, Andres E Ruf, Adriana Varón, Mariano Cartier, Roberto Pérez Ravier, Ezequiel Ridruejo, Mirta Peralta, Daniel Poncino, Julio Vorobioff, Gabriel Aballay Soteras, Marcelo O Silva
Information about the use of ombitasvir/paritaprevir/ritonavir/dasabuvir ± ribavirin (OBV/PTV/r/DSV ± RBV) in real-clinical practice in Latin America is scarce. We aimed to confirm safety and effectiveness of OBV/PTV/r/DSV ± RBV therapy in real-world setting. We analyzed a cohort of patients with genotype 1 infection treated with OBV/PTV/r/DSV ± RBV. Data on demographics, clinical features, safety, and virological response were retrospectively collected from 21 centers in Latin America. A total of 96 patients received OBV/PTV/r/DSV, associated with RBV in 68% of the cases...
September 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28352893/structural-and-energetic-study-of-cation-%C3%AF-cation-interactions-in-proteins
#5
Silvana Pinheiro, Ignacio Soteras, Josep Lluis Gelpí, François Dehez, Christophe Chipot, F Javier Luque, Carles Curutchet
Cation-π interactions of aromatic rings and positively charged groups are among the most important interactions in structural biology. The role and energetic characteristics of these interactions are well established. However, the occurrence of cation-π-cation interactions is an unexpected motif, which raises intriguing questions about its functional role in proteins. We present a statistical analysis of the occurrence, composition and geometrical preferences of cation-π-cation interactions identified in a set of non-redundant protein structures taken from the Protein Data Bank...
April 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28256696/-current-state-of-the-attention-deficit-hyperactivity-disorder-approach-in-neuropediatrics
#6
E Cardo, G Ros-Cervera, J Eiris-Punal, C Escofet-Soteras, A Fernandez-Jaen, F Mulas, R Sanchez-Carpintero, A Sans, Grupo de Trabajo de Tdah de la Sociedad Espanola de Neurologia Pediatrica Grupo de Trabajo de Tdah de la Sociedad Espanola de Neurologia Pediatrica
AIM: To know the current state of the approach of attention deficit hyperactivity disorder (ADHD) in neuropediatricians. SUBJECTS AND METHODS: A telematic survey was carried out to collect preliminary information on the interest, difficulties in the management and treatment of ADHD to the 437 fellowship of the Neuropediactric Spanish Society (SENEP). RESULTS: Only 32.49% of the sent questionnaires were answered, with important geographic variability...
February 24, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28073514/erratum-to-clinical-consequences-of-using-the-new-cardiovascular-risk-tables-score-op-in-patients-aged-over-65-years
#7
Carlos Brotons, Irene Moral, Diana Fernández, Lluis Cuixart, Alex Muñoz, Anna Soteras, Mireia Puig, Xavier Joaniquet, Albert Casasa
No abstract text is available yet for this article.
March 3, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/27575527/-clinical-consequences-of-using-the-new-cardiovascular-risk-tables-score-op-in-patients-aged-over-65-years
#8
Carlos Brotons, Irene Moral, Diana Fernández, Lluis Cuixart, Alex Muñox, Anna Soteras, Mireia Puig, Xavier Joaniquet, Albert Casasa
BACKGROUND AND OBJECTIVE: Estimating cardiovascular risk with SCORE is not recommended in persons over 65 years. SCORE investigators have recently published specific tables for older people (SCORE Older Persons [SCORE OP]). The aim of this study is to assess the impact of using SCORE OP tables on a Spanish population aged over 64 years, and compare it with the use of SCORE in patients aged 65-69 years. PATIENTS AND METHOD: Cross-sectional study carried out in 2 urban primary health care centres...
November 4, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27474480/assessment-of-the-new-score-op-cardiovascular-risk-charts-in-patients-older-than-65-years
#9
Carlos Brotons, Irene Moral, Diana Fernández, Lluís Cuixart, Anna Soteras, Mireia Puig
No abstract text is available yet for this article.
October 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27353885/parametrization-of-halogen-bonds-in-the-charmm-general-force-field-improved-treatment-of-ligand-protein-interactions
#10
Ignacio Soteras Gutiérrez, Fang-Yu Lin, Kenno Vanommeslaeghe, Justin A Lemkul, Kira A Armacost, Charles L Brooks, Alexander D MacKerell
A halogen bond is a highly directional, non-covalent interaction between a halogen atom and another electronegative atom. It arises due to the formation of a small region of positive electrostatic potential opposite the covalent bond to the halogen, called the 'sigma hole.' Empirical force fields in which the electrostatic interactions are represented by atom-centered point charges cannot capture this effect because halogen atoms usually carry a negative charge and therefore interact unfavorably with other electronegative atoms...
October 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27116920/avalanche-survival-after-rescue-with-the-recco-rescue-system-a-case-report
#11
Katharina Grasegger, Giacomo Strapazzon, Emily Procter, Hermann Brugger, Inigo Soteras
We report a case of survival of a completely buried avalanche victim after being located with the radar-based RECCO Rescue System. In the winter of 2015, 2 off-piste skiers were completely buried in an avalanche near the secured ski area in Baqueira Beret, Spain. The first victim was located with the RECCO Rescue System in less than 35 minutes and was alive and conscious at extrication. This system emits radio waves and requires a specific reflector. It is a portable device that is used by more than 600 rescue organizations worldwide, especially in secured ski areas...
June 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26871272/hysteroscopic-myomectomy-outcomes-after-3-month-treatment-with-either-ulipristal-acetate-or-gnrh-analogues-a-retrospective-comparative-study
#12
REVIEW
Javier Monleón Sancho, Verónica Serrano de la Cruz Delgado, Maria José Nuñez Valero, Marta Gurrea Soteras, Vicente Payá Amate, Antonio Abad Carrascosa
Ulipristal Acetate (UPA) modifies the endometrium, as well as fibroids, and therefore it might make hysteroscopic surgery more difficult. To confirm that pre-treatment with UPA is as safe and effective an option as pre-treatment with GnRH analogues, considered the gold standard. We present the first series of 26 hysteroscopic myomectomies after 3 months treatment with UPA and we compare the results with a series of 24 cases pretreated with GnRH analogues. This was a retrospective cohort study between July 2013 and May 2015...
March 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26486528/-validity-and-reliability-of-the-spanish-version-of-the-oral-assessment-guide-oag-in-cancer-patients
#13
C Oroviogoicoechea, A Carvajal, M A Soteras, E Beortegui, C de la Hera, M A Aznárez
BACKGROUND: The Oral Assessment Guide (OAG) is a widely used tool designed for evaluating problems of oral mucous in cancer patients, but it has not been validated in Spanish. The aim of this work is to translate and validate into Spanish the scale of the OAG designed by Eilers. METHOD: The translation process was carried out using the method of back-translation by bilingual translators. The study was carried out with cancer patients, both outpatient and inpatients, of the Hematology/Oncology Department and with oncology nurses...
May 2015: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/25640589/epidemiological-and-medical-aspects-of-canyoning-rescue-operations
#14
Inigo Soteras, Enric Subirats, Giacomo Strapazzon
AIM: To describe the characteristics of canyoning rescue operations (CRO), type and severity of injuries or illnesses, and on-site medical procedures. PATIENTS AND METHODS: A retrospective analysis of all CRO data from an emergency medical rescue team in Aragon, Spain, between 1 August 1999 and 31 July 2009. RESULTS: A total of 520 patients were identified, with a male to female ratio of 1.4. The median age was 32 years (range 10-73 years)...
April 2015: Injury
https://www.readbyqxmd.com/read/25263447/p53-protein-aggregation-promotes-platinum-resistance-in-ovarian-cancer
#15
Y Yang-Hartwich, M G Soteras, Z P Lin, J Holmberg, N Sumi, V Craveiro, M Liang, E Romanoff, J Bingham, F Garofalo, A Alvero, G Mor
High-grade serous ovarian carcinoma (HGSOC), the most lethal gynecological cancer, often leads to chemoresistant diseases. The p53 protein is a key transcriptional factor regulating cellular homeostasis. A majority of HGSOCs have inactive p53 because of genetic mutations. However, genetic mutation is not the only cause of p53 inactivation. The aggregation of p53 protein has been discovered in different types of cancers and may be responsible for impairing the normal transcriptional activation and pro-apoptotic functions of p53...
July 2015: Oncogene
https://www.readbyqxmd.com/read/25242945/arbuscular-mycorrhizal-fungi-in-saline-soils-vertical-distribution-at-different-soil-depth
#16
Alejandra Becerra, Norberto Bartoloni, Noelia Cofré, Florencia Soteras, Marta Cabello
Arbuscular mycorrhizal fungi (AMF) colonize land plants in every ecosystem, even extreme conditions such as saline soils. In the present work we report for the first time the mycorrhizal status and the vertical fungal distribution of AMF spores present in the rhizospheric soil samples of four species of Chenopodiaceae (Allenrolfea patagonica, Atriplex argentina, Heterostachys ritteriana and Suaeda divaricata) at five different depths in two saline of central Argentina. Roots showed medium, low or no colonization (0-50%)...
2014: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/25135607/ovulation-and-extra-ovarian-origin-of-ovarian-cancer
#17
Yang Yang-Hartwich, Marta Gurrea-Soteras, Natalia Sumi, Won Duk Joo, Jennie C Holmberg, Vinicius Craveiro, Ayesha B Alvero, Gil Mor
The mortality rate of ovarian cancer remains high due to late diagnosis and recurrence. A fundamental step toward improving detection and treatment of this lethal disease is to understand its origin. A growing number of studies have revealed that ovarian cancer can develop from multiple extra-ovarian origins, including fallopian tube, gastrointestinal tract, cervix and endometriosis. However, the mechanism leading to their ovarian localization is not understood. We utilized in vitro, ex vivo, and in vivo models to recapitulate the process of extra-ovarian malignant cells migrating to the ovaries and forming tumors...
2014: Scientific Reports
https://www.readbyqxmd.com/read/25026889/analysis-of-three-strategies-to-increase-screening-coverage-for-cervical-cancer-in-the-general-population-of-women-aged-60-to-70%C3%A2-years-the-cricerva-study
#18
RANDOMIZED CONTROLLED TRIAL
Amelia Acera, Josep Maria Manresa, Diego Rodriguez, Ana Rodriguez, Josep Maria Bonet, Norman Sanchez, Pablo Hidalgo, Pilar Soteras, Pere Toran, Marta Trapero-Bertran, Iris Lozano, Silvia De Sanjose
BACKGROUND: Cervical cancer is a frequently diagnosed cancer in women worldwide. Despite having easy preventive and therapeutic approaches, it is an important cause of mortality among women. METHODS: The CRICERVA study is a cluster clinical trial which assigned one of three interventions to the target population registered in Cerdanyola, Barcelona. Among the 5,707 resident women aged 60 to 70 years in the study area, women with no record of cervical cytology over the last three years were selected...
July 16, 2014: BMC Women's Health
https://www.readbyqxmd.com/read/24706095/on-simulating-sustained-isometric-muscle-fatigue-a-phenomenological-model-considering-different-fiber-metabolisms
#19
J Grasa, M Sierra, M J Muñoz, F Soteras, R Osta, B Calvo, F J Miana-Mena
The present study shows a new computational FEM technique to simulate the evolution of the mechanical response of 3D muscle models subjected to fatigue. In an attempt to obtain very realistic models, parameters needed to adjust the mathematical formulation were obtained from in vivo experimental tests. The fatigue contractile properties of three different rat muscles (Tibialis Anterior, Extensor Digitorium Longus and Soleus) subjected to sustained maximal isometric contraction were determined. Experiments were conducted on three groups [Formula: see text] of male Wistar rats [Formula: see text] using a protocol previously developed by the authors for short tetanic contractions...
November 2014: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/24239625/unraveling-phosphodiesterase-surfaces-identification-of-phosphodiesterase-7-allosteric-modulation-cavities
#20
Miriam Redondo, Ignacio Soteras, José Brea, Alejandro González-García, María Isabel Cadavid, María Isabel Loza, Ana Martinez, Carmen Gil, Nuria E Campillo
The last findings of our group by using chemical genetic approaches have shown that PDE7 is an interesting target in neurodegenerative diseases. The following step in this travel to unravel PDE7 is the design of more selective inhibitors. In this sense we have proposed to perform an analysis of PDE7 surface to identify possible allosteric sites following by a docking study of different PDE7 inhibitors synthesized by our group. Thanks to these studies we have proved the existence of allosteric sites in PDE7 and we have been able to explain the binding modes of the employed PDE7 inhibitors...
2013: European Journal of Medicinal Chemistry
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