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Carlos Brotons, Irene Moral, Diana Fernández, Lluis Cuixart, Alex Muñox, Anna Soteras, Mireia Puig, Xavier Joaniquet, Albert Casasa
BACKGROUND AND OBJECTIVE: Estimating cardiovascular risk with SCORE is not recommended in persons over 65 years. SCORE investigators have recently published specific tables for older people (SCORE Older Persons [SCORE OP]). The aim of this study is to assess the impact of using SCORE OP tables on a Spanish population aged over 64 years, and compare it with the use of SCORE in patients aged 65-69 years. PATIENTS AND METHOD: Cross-sectional study carried out in 2 urban primary health care centres...
November 4, 2016: Medicina Clínica
Carlos Brotons, Irene Moral, Diana Fernández, Lluís Cuixart, Anna Soteras, Mireia Puig
No abstract text is available yet for this article.
October 2016: Revista Española de Cardiología
Ignacio Soteras Gutiérrez, Fang-Yu Lin, Kenno Vanommeslaeghe, Justin A Lemkul, Kira A Armacost, Charles L Brooks, Alexander D MacKerell
A halogen bond is a highly directional, non-covalent interaction between a halogen atom and another electronegative atom. It arises due to the formation of a small region of positive electrostatic potential opposite the covalent bond to the halogen, called the 'sigma hole.' Empirical force fields in which the electrostatic interactions are represented by atom-centered point charges cannot capture this effect because halogen atoms usually carry a negative charge and therefore interact unfavorably with other electronegative atoms...
June 18, 2016: Bioorganic & Medicinal Chemistry
Katharina Grasegger, Giacomo Strapazzon, Emily Procter, Hermann Brugger, Inigo Soteras
We report a case of survival of a completely buried avalanche victim after being located with the radar-based RECCO Rescue System. In the winter of 2015, 2 off-piste skiers were completely buried in an avalanche near the secured ski area in Baqueira Beret, Spain. The first victim was located with the RECCO Rescue System in less than 35 minutes and was alive and conscious at extrication. This system emits radio waves and requires a specific reflector. It is a portable device that is used by more than 600 rescue organizations worldwide, especially in secured ski areas...
June 2016: Wilderness & Environmental Medicine
Javier Monleón Sancho, Verónica Serrano de la Cruz Delgado, Maria José Nuñez Valero, Marta Gurrea Soteras, Vicente Payá Amate, Antonio Abad Carrascosa
Ulipristal Acetate (UPA) modifies the endometrium, as well as fibroids, and therefore it might make hysteroscopic surgery more difficult. To confirm that pre-treatment with UPA is as safe and effective an option as pre-treatment with GnRH analogues, considered the gold standard. We present the first series of 26 hysteroscopic myomectomies after 3 months treatment with UPA and we compare the results with a series of 24 cases pretreated with GnRH analogues. This was a retrospective cohort study between July 2013 and May 2015...
March 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
C Oroviogoicoechea, A Carvajal, M A Soteras, E Beortegui, C de la Hera, M A Aznárez
BACKGROUND: The Oral Assessment Guide (OAG) is a widely used tool designed for evaluating problems of oral mucous in cancer patients, but it has not been validated in Spanish. The aim of this work is to translate and validate into Spanish the scale of the OAG designed by Eilers. METHOD: The translation process was carried out using the method of back-translation by bilingual translators. The study was carried out with cancer patients, both outpatient and inpatients, of the Hematology/Oncology Department and with oncology nurses...
May 2015: Anales del Sistema Sanitario de Navarra
Inigo Soteras, Enric Subirats, Giacomo Strapazzon
AIM: To describe the characteristics of canyoning rescue operations (CRO), type and severity of injuries or illnesses, and on-site medical procedures. PATIENTS AND METHODS: A retrospective analysis of all CRO data from an emergency medical rescue team in Aragon, Spain, between 1 August 1999 and 31 July 2009. RESULTS: A total of 520 patients were identified, with a male to female ratio of 1.4. The median age was 32 years (range 10-73 years)...
April 2015: Injury
Y Yang-Hartwich, M G Soteras, Z P Lin, J Holmberg, N Sumi, V Craveiro, M Liang, E Romanoff, J Bingham, F Garofalo, A Alvero, G Mor
High-grade serous ovarian carcinoma (HGSOC), the most lethal gynecological cancer, often leads to chemoresistant diseases. The p53 protein is a key transcriptional factor regulating cellular homeostasis. A majority of HGSOCs have inactive p53 because of genetic mutations. However, genetic mutation is not the only cause of p53 inactivation. The aggregation of p53 protein has been discovered in different types of cancers and may be responsible for impairing the normal transcriptional activation and pro-apoptotic functions of p53...
July 2015: Oncogene
Alejandra Becerra, Norberto Bartoloni, Noelia Cofré, Florencia Soteras, Marta Cabello
Arbuscular mycorrhizal fungi (AMF) colonize land plants in every ecosystem, even extreme conditions such as saline soils. In the present work we report for the first time the mycorrhizal status and the vertical fungal distribution of AMF spores present in the rhizospheric soil samples of four species of Chenopodiaceae (Allenrolfea patagonica, Atriplex argentina, Heterostachys ritteriana and Suaeda divaricata) at five different depths in two saline of central Argentina. Roots showed medium, low or no colonization (0-50%)...
2014: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Yang Yang-Hartwich, Marta Gurrea-Soteras, Natalia Sumi, Won Duk Joo, Jennie C Holmberg, Vinicius Craveiro, Ayesha B Alvero, Gil Mor
The mortality rate of ovarian cancer remains high due to late diagnosis and recurrence. A fundamental step toward improving detection and treatment of this lethal disease is to understand its origin. A growing number of studies have revealed that ovarian cancer can develop from multiple extra-ovarian origins, including fallopian tube, gastrointestinal tract, cervix and endometriosis. However, the mechanism leading to their ovarian localization is not understood. We utilized in vitro, ex vivo, and in vivo models to recapitulate the process of extra-ovarian malignant cells migrating to the ovaries and forming tumors...
2014: Scientific Reports
Amelia Acera, Josep Maria Manresa, Diego Rodriguez, Ana Rodriguez, Josep Maria Bonet, Norman Sanchez, Pablo Hidalgo, Pilar Soteras, Pere Toran, Marta Trapero-Bertran, Iris Lozano, Silvia De Sanjose
BACKGROUND: Cervical cancer is a frequently diagnosed cancer in women worldwide. Despite having easy preventive and therapeutic approaches, it is an important cause of mortality among women. METHODS: The CRICERVA study is a cluster clinical trial which assigned one of three interventions to the target population registered in Cerdanyola, Barcelona. Among the 5,707 resident women aged 60 to 70 years in the study area, women with no record of cervical cytology over the last three years were selected...
2014: BMC Women's Health
J Grasa, M Sierra, M J Muñoz, F Soteras, R Osta, B Calvo, F J Miana-Mena
The present study shows a new computational FEM technique to simulate the evolution of the mechanical response of 3D muscle models subjected to fatigue. In an attempt to obtain very realistic models, parameters needed to adjust the mathematical formulation were obtained from in vivo experimental tests. The fatigue contractile properties of three different rat muscles (Tibialis Anterior, Extensor Digitorium Longus and Soleus) subjected to sustained maximal isometric contraction were determined. Experiments were conducted on three groups [Formula: see text] of male Wistar rats [Formula: see text] using a protocol previously developed by the authors for short tetanic contractions...
November 2014: Biomechanics and Modeling in Mechanobiology
Miriam Redondo, Ignacio Soteras, José Brea, Alejandro González-García, María Isabel Cadavid, María Isabel Loza, Ana Martinez, Carmen Gil, Nuria E Campillo
The last findings of our group by using chemical genetic approaches have shown that PDE7 is an interesting target in neurodegenerative diseases. The following step in this travel to unravel PDE7 is the design of more selective inhibitors. In this sense we have proposed to perform an analysis of PDE7 surface to identify possible allosteric sites following by a docking study of different PDE7 inhibitors synthesized by our group. Thanks to these studies we have proved the existence of allosteric sites in PDE7 and we have been able to explain the binding modes of the employed PDE7 inhibitors...
2013: European Journal of Medicinal Chemistry
F Giannitti, C A Margineda, M S Cid, C Montobbio, C I Soteras, R D Caffarena, S S Diab
A group of 342 beef calves, corralled in the Patagonia region of Argentina, were fed alfalfa hay that had been inadvertently contaminated with Wedelia glauca. A total of 147 (43%) calves died within 4 days. Pathologic findings in 2 calves were diffuse centrilobular hepatic necrosis and hemorrhage with edema in the gallbladder, common bile duct, and choledochoduodenal junction. Epidermal fragments of W. glauca were identified in rumen contents by microscopy. Intact W. glauca plants and leaf fragments were found in the hay...
May 2013: Veterinary Pathology
Ilana Chefetz, Ayesha B Alvero, Jennie C Holmberg, Noah Lebowitz, Vinicius Craveiro, Yang Yang-Hartwich, Gang Yin, Lisa Squillace, Marta Gurrea Soteras, Paulomi Aldo, Gil Mor
Primary ovarian cancer is responsive to treatment, but chemoresistant recurrent disease ensues in majority of patients. Recent compelling evidence demonstrates that a specific population of cancer cells, the cancer stem cells, initiates and sustains tumors. It is therefore possible that this cell population is also responsible for recurrence. We have shown previously that CD44+/MyD88+ epithelial ovarian cancer stem cells (CD44+/MyD88+ EOC stem cells) are responsible for tumor initiation. In this study, we demonstrate that this population drives tumor repair following surgery- and chemotherapy-induced tumor injury...
February 1, 2013: Cell Cycle
Miriam Redondo, José Brea, Daniel I Perez, Ignacio Soteras, Cristina Val, Concepción Perez, Jose A Morales-García, Sandra Alonso-Gil, Nuria Paul-Fernandez, Rocío Martin-Alvarez, María Isabel Cadavid, María Isabel Loza, Ana Perez-Castillo, Guadalupe Mengod, Nuria E Campillo, Ana Martinez, Carmen Gil
Phosphodiesterase (PDE) 7 is involved in proinflammatory processes, being widely expressed both on lymphocytes and on certain brain regions. Specific inhibitors of PDE7 have been recently reported as potential new drugs for the treatment of neurological disorders because of their ability to increase intracellular levels of cAMP and thus to modulate the inflammatory process, as a neuroprotective well-established strategy. Multiple sclerosis is an unmet disease in which pathologies on the immune system, T-cells, and specific neural cells are involved simultaneously...
April 12, 2012: Journal of Medicinal Chemistry
E J Riley, R B Sozio, F Casthely, M T Wilcko, A J Sotera
A simple technique for construction of an aluminous porcelain crown has been described. An aluminous core is fabricated without platinum foil on a ceramic refractory die and, when retrieved, serves as a coping on the master cast. The technique and accuracy of fit are illustrated with the fabrication of an aluminous porcelain crown on the Bureau of Standards' full-crown die.
September 1975: Journal of Prosthetic Dentistry
M L Avellanas, A Ricart, J Botella, F Mengelle, I Soteras, T Veres, M Vidal
Accidental hypothermia is an environmental condition with basic principles of classification and resuscitation that apply to mountain, sea or urban scenarios. Along with coagulopathy and acidosis, hypothermia belongs to the lethal triad of trauma victims requiring critical care. A customized healthcare chain is involved in its management, extending from on site assistance to intensive care, cardiac surgery and/or the extracorporeal circulation protocols. A good classification of the degree of hypothermia preceding admission contributes to improve management and avoids inappropriate referrals between hospitals...
April 2012: Medicina Intensiva
Valle Palomo, Daniel I Perez, Concepcion Perez, Jose A Morales-Garcia, Ignacio Soteras, Sandra Alonso-Gil, Arantxa Encinas, Ana Castro, Nuria E Campillo, Ana Perez-Castillo, Carmen Gil, Ana Martinez
Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important therapeutic target in severe unmet human diseases. GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders. As GSK-3 has the ability to phosphorylate primed substrates, small molecules able to bind to this site should be perfect drug candidates, able to partially block the activity of the enzyme over some specific substrates...
February 23, 2012: Journal of Medicinal Chemistry
Fidel Elsensohn, Inigo Soteras, Oliver Resiten, John Ellerton, Hermann Brugger, Peter Paal
We conducted a survey of equipment in medical backpacks for mountain rescuers and mountain emergency physicians. The aim was to investigate whether there are standards for medical equipment in mountain rescue organizations associated with the International Commission for Mountain Emergency Medicine (ICAR MEDCOM). A questionnaire was completed by 18 member organizations from 14 countries. Backpacks for first responders are well equipped to manage trauma, but deficiencies in equipment to treat medical emergencies were found...
2011: High Altitude Medicine & Biology
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