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https://www.readbyqxmd.com/read/28540211/delayed-enhancement-cardiac-computed-tomography-for-the-assessment-of-myocardial-infarction-from-bench-to-bedside
#1
REVIEW
Gaston A Rodriguez-Granillo
A large number of studies support the increasingly relevant prognostic value of the presence and extent of delayed enhancement (DE), a surrogate marker of fibrosis, in diverse etiologies. Gadolinium and iodinated based contrast agents share similar kinetics, thus leading to comparable myocardial characterization with cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) at both first-pass perfusion and DE imaging. We review the available evidence of DE imaging for the assessment of myocardial infarction (MI) using cardiac CT (CTDE), from animal to clinical studies, and from 16-slice CT to dual-energy CT systems (DECT)...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28539984/birt-hogg-dub%C3%A3-syndrome-report-of-two-cases-with-two-new-mutations
#2
Margarida Rato, Ana Filipe Monteiro, Joana Parente, João Aranha, Ermelindo Tavares
INTRODUCTION: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis characterized by cutaneous fibrofolliculomas and/or trichodiscomas, lung cysts, spontaneous pneumothorax and renal tumors. However, its clinical expression is highly variable. This syndrome is caused by germline mutations in the folliculin gene (FLCN) on chromosome 17p11.2. MAIN OBSERVATIONS: Two men, 60 and 39-year-old, presented with a several year history of asymptomatic whitish papules scattered over the face and neck...
March 31, 2017: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28538066/radial-forearm-osteocutaneous-free-flap-for-reconstruction-of-hard-palate-with-alveolar-defect
#3
Euicheol C Jeong, Sehoon Yoon, Young Ho Jung
The radial forearm free flap is beneficial for reconstruction of large palatal defect with oronasal fistula.A 51-year-old male patient who had anterior palate defect including alveolus after the radiation therapy of malignant cancer on the nasopharyngeal area undertook the radial forearm osteocutaneous free flap to close the oronasal fisula and restore the alveolar arch. The small radial bone segment was fixed in the alveolar defect and vascular anastomoses were performed with facial vessels in neck. The donor site was closed with split thickness skin graft...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28533643/unsuspected-active-ulcerative-colitis-in-a-patient-with-dermatomyositis-a-rare-association-detected-on-18-f-fdg-pet-ct-during-the-search-for-an-occult-malignancy
#4
Sampanna Jung Rayamajhi, Arun Kumar Reddy Gorla, Rajender Kumar Basher, Ashwani Sood, Bhagwant Rai Mittal
Dermatomyositis is an inflammatory myopathy with the characteristic features of skin rash and myopathy. We here present a known case of dermatomyositis evaluated with (18)F-FDG PET/CT for the presence of any occult malignancy. The scan was negative for the presence of any malignancy. However, it revealed multiple intensely FDG avid colonic strictures that were later proven on colonoscopic biopsy to be ulcerative colitis. Also, a well-known association of bilateral sacroilitis was simultaneously demonstrated on the scan...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28528851/microstructure-evaluation-of-dermally-applicable-liquid-crystals-as-a-function-of-water-content-and-temperature-can-electron-paramagnetic-resonance-provide-complementary-data
#5
Mirjam Gosenca Matjaž, Janez Mravljak, Marija Bešter Rogač, Marjeta Šentjurc, Mirjana Gašperlin, Alenka Zvonar Pobirk
Insight into the microstructure of lyotropic liquid crystals (LCs) is of crucial importance for development of novel dermal delivery systems. Our aim was to evaluate the phase behaviour of dermally applicable LCs composed of isopropyl myristate/Tween 80/lecithin/water, along the dilution line, where phase transitions are predominantly driven by increased water content. Additionally, identification of LC temperature dependence is of great importance for skin application. Selected LCs were evaluated using electron paramagnetic resonance (EPR) plus conventionally used methods of polarization microscopy, small-angle X-ray scattering, differential scanning calorimetry, and rheological measurements...
May 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28527126/polycaprolactone-based-nanoparticles-loaded-with-indomethacin-for-anti-inflammatory-therapy-from-preparation-to-ex-vivo-study
#6
Waisudin Badri, Karim Miladi, Sophie Robin, Céline Viennet, Qand Agha Nazari, Géraldine Agusti, Hatem Fessi, Abdelhamid Elaissari
PURPOSE: This work focused on the preparation of polycaprolactone based nanoparticles containing indomethacin to provide topical analgesic and anti-inflammatory effect for symptomatic treatment of inflammatory diseases. Indomethacin loaded nanoparticles are prepared for topical application to decrease indomethacin side effects and administration frequency. Oppositely to already reported works, in this research non-invasive method has been used for the enhancement of indomethacin dermal drug penetration...
May 19, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28522423/sertaconazole-nitrate-loaded-nanovesicular-systems-for-targeting-skin-fungal-infection-in-vitro-ex-vivo-and-in-vivo-evaluation
#7
Menna M Abdellatif, Islam A Khalil, Mahmoud A F Khalil
The aim of this study was to develop different vesicular systems for sertaconazole nitrate and evaluate the ability of targeting deep skin layers to treat dermal fungal infection. Therefore, different phospholipid based nanovesicles, namely liposomes, glycerosomes, transferosmes and ethosomes were prepared and in-vitro evaluated for morphology, entrapment efficiency, vesicle size and zeta potential value, followed by ex-vivo evaluation through skin penetration and permeation. The selected vesicular formula was incorporated into gel base system and assessed by ex-vivo permeation visualization study using confocal laser scanning microscopy (CLSM)...
May 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28516572/identification-of-ageing-biomarkers-in-human-dermis-biopsies-by-thermal-analysis-dsc-combined-with-fourier-transform-infrared-spectroscopy-ftir-atr
#8
R Tang, V Samouillan, J Dandurand, C Lacabanne, M-H Lacoste-Ferre, P Bogdanowicz, P Bianchi, A Villaret, F Nadal-Wollbold
BACKGROUND/PURPOSE: The purpose of this clinical study was to identify suitable biomarkers for a better understanding of the molecular and organizational changes in human dermis during intrinsic and extrinsic ageing. METHODS: Sun-exposed and non-exposed skin biopsies were collected from twenty-eight women devised in two groups (20-30 and ≥60 years old). The hydric organization and thermal transitions were determined by Differential Scanning Calorimetry (DSC)...
May 17, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28516571/fsoca-induced-switchable-footpad-skin-optical-clearing-window-for-blood-flow-and-cell-imaging-in%C3%A2-vivo
#9
Rui Shi, Wei Feng, Chao Zhang, Zhihong Zhang, Dan Zhu
The mouse footpad for its feature of hairlessness provides an available window for imaging vascular and cellular structure and function in vivo. Unfortunately, the strong scattering of its skin limits the penetration of light and reduces the imaging contrast and depth. Herein, an innovative footpad skin optical clearing agent (FSOCA) was developed to make the footpad skin transparent quickly by topical application. The results demonstrate that FSOCA treatment not only allowed the cutaneous blood vessels and blood flow distribution to be monitored by laser speckle contrast imaging technique with higher contrast, but also permitted the fluorescent cells to be imaged by laser scanning confocal microscopy with higher fluorescence signal intensity and larger imaging depth...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28514014/repeatability-of-vessel-density-measurement-in-human-skin-by-oct-based-microangiography
#10
S J Men, C-L Chen, W Wei, T-Y Lai, S Z Song, R K Wang
PURPOSE: To investigate the repeatability of vessel density measurement at human arm skin in healthy subjects with OCT-based microangiography (OMAG). METHODS: Four locations including volar wrist, volar forearm, shoulder, and volar upper arm were scanned using an optimized swept source OCT system, working at center wavelength of 1300 nm and A-line rate of 100 kHz. Three scans were acquired at each location at the same visit. Vascular images of papillary dermis, reticular dermis, and the whole dermis layer were generated with OMAG processing and automatic segmentation algorithms...
May 17, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28511585/three-phase-adaptive-radiation-therapy-for-patients-with-nasopharyngeal-carcinoma-undergoing-intensity-modulated-radiation-therapy-dosimetric-analysis
#11
Shan Deng, Xu Liu, Heming Lu, Huixian Huang, Liuyang Shu, Hailan Jiang, Jinjian Cheng, Luxing Peng, Qiang Pang, Junzhao Gu, Jian Qin, Zhiping Lu, Ying Mo, Danling Wu, Yinglin Wei
Patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy may experience significant anatomic changes throughout the entire treatment course, and adaptive radiation therapy may be necessary to maintain optimal dose delivered both to the targets and to the critical structures. The timing of adaptive radiation therapy, however, is largely unknown. This study was to evaluate the dosimetric benefits of a 3-phase adaptive radiation therapy technique for nasopharyngeal carcinoma. Twenty patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy were recruited prospectively...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28504937/ultrasonic-fingerprint-sensor-with-transmit-beamforming-based-on-a-pmut-array-bonded-to-cmos-circuitry
#12
Xiaoyue Jiang, Hao-Yen Tang, Yipeng Lu, Eldwin Ng, Julius Tsai, Bernhard Boser, David Horsley
In this paper, we present a single-chip 65x42 element ultrasonic pulse-echo fingerprint sensor with transmit beamforming based on piezoelectric micromachined ultrasonic transducers (PMUTs) directly bonded to a CMOS readout ASIC. The readout ASIC was realized in a standard 180 nm CMOS process with a 24V high voltage transistor option. Pulse-echo measurements are performed column-by-column in sequence using either one column or five columns to transmit the ultrasonic pulse at 20 MHz. Transmit beamforming is used to focus the ultrasonic beam at the imaging plane where the finger is located, increasing the ultrasonic pressure and narrowing the 3dB beam-width to 50 microns, a factor of 6...
May 11, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28504046/formulation-and-characterization-of-phospholipon%C3%A2-90%C3%A2-g-and-tween-%C3%A2-80-based-transfersomes-for-transdermal-delivery-of-eprosartan-mesylate
#13
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of the current study was to formulate the eprosartan mesylate loaded transfersomes using different proportions of Phospholipon(®) 90 G and Tween(®) 80 (95-75: 5-25% w/w). The prepared transfersomes were characterized for their vesicles size, shape, polydispersity index, zeta potential, entrapment efficiency, in vitro skin permeation, confocal laser scanning microscopy and in vivo skin irritation. Results revealed that the formulated transfersomes were negatively charged, spherical unilamellar structure of 71...
May 15, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28501387/surgical-treatment-of-isolated-zygomatic-fracture-outcome-comparison-between-titanium-plate-and-bioabsorbable-plate
#14
Chao-Ming Wu, Ying-An Chen, Han-Tsung Liao, Chih-Hao Chen, Chun-Hao Pan, Chien-Tzung Chen
BACKGROUND: Zygoma fracture is of clinical importance because malar prominence plays an essential role in facial appearance. Traditionally, most maxillofacial surgeons perform osteosynthesis with titanium plates and screws for rigid fixation. However, this procedure has certain disadvantages that include the possibility of implant exposure, palpability or loosening of the screws, painful irritation, temperature sensitization, and radiographic artifacts. In this study, we compared the function and satisfaction outcome between Bonamates(®) bioabsorbable implant and Leibinger titanium implant...
May 10, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28497441/-cryptogenic-stroke-in-a-young-patient-with-heart-disease-and-kidney-failure
#15
B Oyanguren, R Segoviano, E Alegria, E Besada, M Gonzalez-Salaices, M Eimil-Ortiz, C Lopez de Silanes
INTRODUCTION: Fabry's disease is an infrequent metabolic pathology linked to the X chromosome which causes a wide variety of signs and symptoms. CASE REPORT: A 39-year-old male who was admitted to our stroke unit with right-side hemiparesis (1 + 0) and dysarthria (1). The score on the National Institute of Health Stroke Scale was 2. The patient presented angiokeratomas in both thighs. A computerised axial tomography scan of the head showed left thalamic acute infarction...
May 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28494373/influence-of-li-charge-compensator-ion-on-the-energy-transfer-from-pr-3-to-gd-3-ions-in-ca9mg-po4-6f2-gd-3-pr-3-li-phosphor
#16
Sumedha Tamboli, S J Dhoble
Phototherapy is a renowned treatment for curing skin diseases since ancient times. Phototherapeutic treatment for psoriasis and many other diseases require narrow band ultra violet-B (NB-UVB) light with peak intensity at 313nm to be exposed to the affected part of body. In this paper, we report combustion synthesis of NB-UVB -313nm emitting Ca9Mg(PO4)6F2 phosphors doped with Gd(3+), Pr(3+) and Li(+) ions. The phase formation was confirmed by obtaining X-ray diffraction (XRD) pattern and morphology was studied with the Scanning electron microscopy (SEM) images...
May 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28493940/monte-carlo-simulation-for-scanning-technique-with-scattering-foil-free-electron-beam-a-proof-of-concept-study
#17
Wonmo Sung, Jong In Park, Jung-In Kim, Joel Carlson, Sung-Joon Ye, Jong Min Park
This study investigated the potential of a newly proposed scattering foil free (SFF) electron beam scanning technique for the treatment of skin cancer on the irregular patient surfaces using Monte Carlo (MC) simulation. After benchmarking of the MC simulations, we removed the scattering foil to generate SFF electron beams. Cylindrical and spherical phantoms with 1 cm boluses were generated and the target volume was defined from the surface to 5 mm depth. The SFF scanning technique with 6 MeV electrons was simulated using those phantoms...
2017: PloS One
https://www.readbyqxmd.com/read/28493850/importance-of-endogenous-extracellular-matrix-in-biomechanical-properties-of-human-skin-model
#18
Flavien Pillet, Laure Gibot, Moinecha Madi, Marie-Pierre Rols, Etienne Dague
The physical and mechanical properties of cells modulate their behavior such proliferation rate, migration and extracellular matrix remodeling. In order to study cell behavior in a tissue-like environment in vitro, it is of utmost importance to develop biologically and physically relevant 3D cell models. Here, we characterized the physical properties of a single cell type growing in configurations of increasing complexity. From one human skin biopsy, primary dermal fibroblasts were isolated and seeded to give monolayer (2D model), spheroid (3D model poor in extracellular matrix) and tissue-engineered cell sheet (3D model rich in endogenous extracellular matrix)...
May 11, 2017: Biofabrication
https://www.readbyqxmd.com/read/28493610/fractionated-aliphatic-alcohols-as-synthetic-precursors-of-ultra-long-chain-monoacylglycerols-for-cosmetic-applications
#19
Bianca Pérez, Bjørn S Hansen, Pallav A Bulsara, Anthony Vincent Rawlings, Martyn J Clarke, Zheng Guo
BACKGROUND: Xerosis is an abnormally dry and flaky skin condition that is associated with a change in the packing behavior of the lipid matrix in the stratum corneum (SC), the outermost layer of the skin. This skin condition can lead to an increase in transepidermal water loss (TEWL). Since ultralong chain fatty acids have a positive effect on maintaining the packing behavior of the SC lipid matrix, a moisturizer which contains glycerides of ultralong chain fatty acids could act as an semi-occlusive layer on the surface of the skin...
May 11, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28491316/pituitary-abscess-in-an-hiv-1-infected-patient
#20
Hiroyuki Yamazaki, Masayuki Kobayashi, Anamaria Daniela Sarca, Akifumi Takaori-Kondo
OBJECTIVES: Pituitary abscess is a rare occurrence among pituitary conditions, but one which carries life-threatening potential. An immunocompromised status is a risk factor for the development of a pituitary abscess; however, literature describes only one case among HIV-infected patients. METHODS AND RESULTS: We present here a case of pituitary abscess in an HIV-1-positive patient, who demonstrated a shock status, disturbance of consciousness and generalized skin rash with laboratory findings of hypovolemia, acute inflammatory reaction and blood electrolyte abnormality...
2017: SAGE open medical case reports
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