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https://www.readbyqxmd.com/read/28439965/identifying-signatures-of-positive-selection-in-pigmentation-genes-in-two-south-asian-populations
#1
Manjari Jonnalagadda, Neeraj Bharti, Yatish Patil, Shantanu Ozarkar, Sunitha Manjari K, Rajendra Joshi, Heather Norton
OBJECTIVES: Skin pigmentation is a polygenic trait showing wide phenotypic variations among global populations. While numerous pigmentation genes have been identified to be under positive selection among European and East populations, genes contributing to phenotypic variation in skin pigmentation within and among South Asian populations are still poorly understood. The present study uses data from the Phase 3 of the 1000 genomes project focusing on two South Asian populations-GIH (Gujarati Indian from Houston, Texas) and ITU (Indian Telugu from UK), so as to decode the genetic architecture involved in adaptation to ultraviolet radiation in South Asian populations...
April 24, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28439521/dynamic-electronic-collimation-method-for-3-d-catheter-tracking-on-a-scanning-beam-digital-x-ray-system
#2
David A P Dunkerley, Jordan M Slagowski, Tobias Funk, Michael A Speidel
Scanning-beam digital x-ray (SBDX) is an inverse geometry x-ray fluoroscopy system capable of tomosynthesis-based 3-D catheter tracking. This work proposes a method of dose-reduced 3-D catheter tracking using dynamic electronic collimation (DEC) of the SBDX scanning x-ray tube. This is achieved through the selective deactivation of focal spot positions not needed for the catheter tracking task. The technique was retrospectively evaluated with SBDX detector data recorded during a phantom study. DEC imaging of a catheter tip at isocenter required 340 active focal spots per frame versus 4473 spots in full field-of-view (FOV) mode...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28436921/feasibility-study-of-entrance-and-exit-dose-measurements-at-the-contra-lateral-breast-with-alanine-electron-spin-resonance-dosimetry-in-volumetric-modulated-radiotherapy-of-breast-cancer
#3
Daniela M Wagner, Petra Huettenrauch, Mathias Anton, Philip von Voigts-Rhetz, Klemens Zink, Hendrik Wolff
PURPOSE: The Physikalisch-Technische Bundesanstalt (PTB) has established a secondary standard measurement system for the dose to water, DW, based on alanine/ ESR (Anton et. al. 2013). The aim of this study was to test the established measurements system for out of field measurements inpatient with breast cancer. METHOD AND MATERIALS: A set of five alanine pellets were affixed to each patients` skin at the contra lateral breast beginning at the sternum and extending over the mammilla to the distal surface...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28433934/amino-acid-functionalized-gadofullerene-nanoparticles-with-superior-antitumor-activity-via-destruction-of-tumor-vasculature-in%C3%A2-vivo
#4
Yue Zhou, Ruijun Deng, Mingming Zhen, Jie Li, Mirong Guan, Wang Jia, Xue Li, Ying Zhang, Tong Yu, Toujun Zou, Zhigao Lu, Jun Guo, Lei Sun, Chunying Shu, Chunru Wang
Researchers have been puzzled of the therapy of malignant tumors and the current therapeutic strategies are always accompanied by toxicity or side effects. Developing efficient nanodrugs could reduce the dosage and greatly improve the therapeutic effects in cancer treatments. Here we initially reported a novel kind of gadofullerene nanoparticles functionalized with amino acid (β-alanine), which exhibited a superior antitumor activity in hepatoma H22 models via a novel therapeutic mechanism. The involvement of β-alanine improved the tumor inhibition rate up to 76...
April 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28433346/biomechanical-flow-amplification-arising-from-the-variable-deformation-of-the-subglottic-mucosa
#5
Eric Goodyer, Frank Müller, Markus Hess, Karthikeyan Kandan, Farukh Farukh
OBJECTIVE: This study mapped the variation in tissue elasticity of the subglottic mucosa, applied these data to provide initial models of the likely deformation of the mucosa during the myoelastic cycle, and hypothesized as to the impact on the process of phonation. STUDY DESIGN: Six donor human larynges were dissected along the sagittal plane to expose the vocal folds and subglottic mucosa. A linear skin rheometer was used to apply a controlled shear force, and the resultant displacement was measured...
April 19, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28425207/bcg-vaccination-induced-suppurative-lymphadenitis-four-signs-to-pay-attention-to
#6
Sang Oon Baek, Hyo Sun Ko, Hyun Ho Han
Suppurative lymphadenitis is one of the severe complication after BCG vaccination, but its diagnostic criteria and treatment guidelines have not yet been established. In this article, we describe a case of suppurative lymphadenitis caused by BCG vaccination and propose diagnostic criteria and treatment guidelines of the disease. The lymphadenitis was presented as skin involving mass and was completely extirpated. Pathological evaluation revealed a necrotising lymphadenitis, consistent with the diagnosis of BCG lymphadenitis...
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28419015/an-unanticipated-complication-of-atopic-dermatitis
#7
Megan E MacGillivray, Loretta Fiorillo
An infant with a history of atopic dermatitis presented to the emergency department on 5 occasions with flulike symptoms. Eventually, this child presented with signs of infection and increased intracranial pressure: fever, bulging anterior fontanel, and leukocytosis. A computed tomography scan identified a large frontal lobe brain abscess. The abscess was surgically drained; culture was positive for Staphylococcus aureus. The initial source of the infected brain abscess was explored. Ultimately, it was thought to be secondary to impetiginized atopic dermatitis, an unusual but serious consequence of a common skin condition...
April 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28417258/in-vivo-facial-soft-tissue-depths-of-a-modern-adult-population-from-germany
#8
Nicolle Thiemann, Volker Keil, Uwe Roy
Forensic facial reconstruction may be the final option available to draw public attention in cases where the identity of an individual cannot be established by standard identification methods. Two fundamental components of all forensic facial reconstruction techniques are cranial morphology and soft tissue depth databases. The purpose of this study was to extend such databases by providing a complete set of accurate facial soft tissue thickness measurements, acquired from a contemporary adult population from Germany...
April 17, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28414661/delayed-presentation-of-tuberour-sclerosis-complex-in-adult-women
#9
J Manalac, S Sadd, G Akoghlanian, T Benoit-Clark
INTRODUCTION: Tuberous sclerosis complex (TSC); is an autosomal dominant disorder characterized by the formation of hamartomatous lesions in multiple organs, with a birth incidence of around one in 10,000. Although it usually manifests itself in early life, we present a case of an adult woman who we diagnosed with TSC. CASE: A 27 year old woman presented to Emergency Department with worsening right flank pain and progressive dyspnea. Physical examination findings revealed Shagreen patches and multiple angiomyolipomas of the skin...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28407835/-recurrent-pulmonary-infection-and-oral-mucosal-ulcer
#10
Fei-Mei Kuang, Lan-Lan Tang, Hui Zhang, Min Xie, Ming-Hua Yang, Liang-Chun Yang, Yan Yu, Li-Zhi Cao
An 8-year-old girl who had experienced intermittent cough and fever over a 3 year period, was admitted after experiencing a recurrence for one month. One year ago the patient experienced a recurrent oral mucosal ulcer. Physical examination showed vitiligo in the skin of the upper right back. Routine blood tests and immune function tests performed in other hospitals had shown normal results. Multiple lung CT scans showed pulmonary infection. The patient had recurrent fever and cough and persistent presence of some lesions after anti-infective therapy...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28402143/a-ph-independent-instantaneous-release-of-flurbiprofen-a-study-of-the-preparation-of-complexes-their-characterization-and-in-vitro-vivo-evaluation
#11
Han-Bing Wang, Fei-Fei Yang, Gai Xiu-Mei, Bing-Chao Cheng, Jin-Yu Li, Hao Pan, Xing-Gang Yang, Wei-San Pan
In this study, furbiprofen/hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complexes were prepared to improve the drug dissolution and facilitate its application in hydrophilic gels. Inclusion complexes were prepared using a supercritical fluid (SCF) processing and a conventional optimized co-lypholization (OCL) method was employed as a reference. The entrapment efficacy (EE) and drug loading (DL) of both methods were investigated. Evaluation of drug dissolution enhancement was conducted in deionized water as well as buffer solutions of different pH...
April 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28401454/use-of-flash-glucose-sensing-technology-for-12%C3%A2-months-as-a-replacement-for-blood-glucose-monitoring-in-insulin-treated-type-2-diabetes
#12
Thomas Haak, Hélène Hanaire, Ramzi Ajjan, Norbert Hermanns, Jean-Pierre Riveline, Gerry Rayman
INTRODUCTION: Published evaluations of sensor glucose monitoring use in insulin treated type 2 diabetes are limited. The aim of this study was to assess the impact of flash glucose-sensing technology as a replacement for self-monitoring of blood glucose (SMBG) over a 12-month period in participants with type 2 diabetes who were on intensive insulin therapy. METHODS: An open-label, randomized, controlled study in adults with type 2 diabetes on intensive insulin therapy from 26 European diabetes centers aimed at assessing flash glucose sensing technology was conducted...
April 11, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28397960/affective-empathy-cognitive-empathy-and-social-attention-in-children-at-high-risk-of-criminal-behaviour
#13
L van Zonneveld, E Platje, L M J de Sonneville, S H M van Goozen, H Swaab
BACKGROUND: Empathy deficits are hypothesized to underlie impairments in social interaction exhibited by those who engage in antisocial behaviour. Social attention is an essential precursor to empathy; however, no studies have yet examined social attention in relation to cognitive and affective empathy in those exhibiting antisocial behaviour. METHODS: Participants were 8- to 12-year-old children at high risk of developing criminal behaviour (N = 114, 80.7% boys) and typically developing controls (N = 43, 72...
April 11, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28395685/the-benefit-of-pharmacological-venous-thromboprophylaxis-in-foot-and-ankle-surgery
#14
N P Saragas, P N F Ferrao, B F Jacobson, E Saragas, A Strydom
BACKGROUND: Ten percent of patients with a deep-vein thrombosis (DVT) will develop a fatal pulmonary embolism (PE), often initially asymptomatic. The risks and benefits of pharmacological thromboprophylaxis are well documented in respect of total joint arthroplasty and hip fractures, but little is understood about the incidence of venous thromboembolism (VTE) or the potential risks and benefits of chemoprophylaxis in foot and ankle surgery. OBJECTIVE: To determine whether prophylactic chemoprophylaxis had any impact on the prevention of VTE in a cohort of foot and ankle surgical patients requiring the combination of below-knee cast immobilisation and non-weightbearing for ≥4 weeks...
March 29, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28394544/fibrin-gel-as-a-scaffold-for-skin-substitute-production-and-clinical-experience
#15
(no author information available yet)
The purpose of this study was to create a fibrin-based human skin substitute in vitro with epidermal and dermal component and to assess its healing potential in deep partial and full thickness burns. Fibrin scaff olds were prepared from commercial fibrin glue kits. Human fibroblasts were cultured in fibrin gel. Human keratinocytes were seeded on the top of the gel. Viability of cells was determined fluorimetrically. Scanning electron microscope and immunocytochemistry analysis of cultured cells were performed...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28391734/analysis-of-tracheostoma-morphology
#16
Maartje Leemans, Maarten J A van Alphen, Michiel W M van den Brekel, Edsko G Hekman
OBJECTIVES: Existing fixation methods of automatic speaking valves (ASVs) suffer from shortcomings which partly are the result of insufficient conformity of the intratracheal fixation method's shape to the tracheostoma anatomy. However, quantitative data are lacking and will be helpful to analyse solutions for airtight fixation. This article provides such data. PATIENTS AND METHODS: The tracheostoma morphology was measured in computerized tomography scans of 20 laryngectomized patients...
April 10, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28388964/breast-and-pleuropulmonary-metastasis-of-multirecurrent-scalp-dermatofibrosarcoma-protuberans-a-case-report
#17
N-A Ouédraogo Nde, N A Ouédraogo, H A Bambara, B M A Tiemtoré-Kambou, F Traoré, N Zongo, M S Ouédraogo, G P Tapsoba, Achach Thouraya Chtioui, A Lamien/Sanou
BACKGROUND: Dermatofibrosarcoma protuberans is a rare tumor, representing about 0.1% of skin malignant tumors. It is characterized by local aggressiveness with significant potential for recurrence. Although metastasis is rare, it does occur. We report a case of a Burkinabe woman with dermatofibrosarcoma protuberans. CASE PRESENTATION: A 27-year-old Burkinabe woman consulted our institution for a recurrent scalp nodule that had been evolving for 13 years. At clinical examination, she was in good condition with a dry cough...
April 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28386508/suspected-pulmonary-metastasis-of-actinic-cutaneous-squamous-cell-carcinoma
#18
Monet E Meter, David J Nye, Christian R Galvez
Introduction. It is rare for actinic or squamous cell carcinoma (SCC) in situ to metastasize. Case Presentation. A 67-year-old male had a significant medical history including severe psoriatic arthritis treated with UVB, methotrexate, and rapamycin. He had twenty-five different skin excisions of actinic keratosis four of which were invasive SCC. Our patient developed shortness of breath necessitating a visit to the emergency department. A CT scan of his chest revealed a mass in the right lower lung. A subsequent biopsy of the mass revealed well-differentiated SCC...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28382139/in-vivo-imaging-of-experimental-melanoma-tumors-using-the-novel-radiotracer-68-ga-nodaga-procainamide-pca
#19
István Kertész, András Vida, Gábor Nagy, Miklós Emri, Antal Farkas, Adrienn Kis, János Angyal, Noémi Dénes, Judit P Szabó, Tünde Kovács, Péter Bai, György Trencsényi
PURPOSE: The most aggressive form of skin cancer is the malignant melanoma. Because of its high metastatic potential the early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of the disease. Previous studies have already shown that benzamide derivatives, such as procainamide (PCA) specifically bind to melanin pigment. The aim of this study was to synthesize and investigate the melanin specificity of the novel (68)Ga-labeled NODAGA-PCA molecule in vitro and in vivo using PET techniques...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28381253/localization-of-staphylococcus-aureus-in-tissue-from-the-nasal-vestibule-in-healthy-carriers
#20
Anne-Merethe Hanssen, Bert Kindlund, Niels Christian Stenklev, Anne-Sofie Furberg, Silje Fismen, Renate Slind Olsen, Mona Johannessen, Johanna Ulrica Ericson Sollid
BACKGROUND: Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers. METHODS: Punch skin biopsies were taken from vestibulum nasi from healthy volunteers (S...
April 5, 2017: BMC Microbiology
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