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https://www.readbyqxmd.com/read/28639707/dressings-and-topical-agents-for-treating-pressure-ulcers
#1
REVIEW
Maggie J Westby, Jo C Dumville, Marta O Soares, Nikki Stubbs, Gill Norman
BACKGROUND: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear and current overview of all the evidence is required to facilitate decision-making regarding the use of dressings or topical agents for the treatment of pressure ulcers...
June 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28633107/effects-of-chemical-and-physical-enhancement-techniques-on-transdermal-delivery-of-3-fluoroamphetamine-hydrochloride
#2
Ashana Puri, Kevin S Murnane, Bruce E Blough, Ajay K Banga
The present study investigated the passive transdermal delivery of 3-fluoroamphetamine hydrochloride (PAL-353) and evaluated the effects of chemical and physical enhancement techniques on its permeation through human skin. In vitro drug permeation studies through dermatomed human skin were performed using Franz diffusion cells. Passive permeation of PAL-353 from propylene glycol and phosphate buffered saline as vehicles was studied. Effect of oleic acid, maltose microneedles, ablative laser, and anodal iontophoresis on its transdermal permeation was investigated...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28632205/speckle-modulating-optical-coherence-tomography-in-living-mice-and-humans
#3
Orly Liba, Matthew D Lew, Elliott D SoRelle, Rebecca Dutta, Debasish Sen, Darius M Moshfeghi, Steven Chu, Adam de la Zerda
Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo. As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by creating and averaging an unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution...
June 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28631809/anabolic-steroids-for-treating-pressure-ulcers
#4
REVIEW
Cho Naing, Maxine A Whittaker
BACKGROUND: Pressure ulcers, also known as bed sores, pressure sores or decubitus ulcers develop as a result of a localised injury to the skin or underlying tissue, or both. The ulcers usually arise over a bony prominence, and are recognised as a common medical problem affecting people confined to a bed or wheelchair for long periods of time. Anabolic steroids are used as off-label drugs (drugs which are used without regulatory approval) and have been used as adjuvants to usual treatment with dressings, debridement, nutritional supplements, systemic antibiotics and antiseptics, which are considered to be supportive in healing of pressure ulcers...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28629075/fabrication-of-chitosan-au-tio2-nanotube-based-dry-electrodes-for-electroencephalography-recording
#5
Yanjuan Song, Penghai Li, Mingji Li, Hongji Li, Cuiping Li, Dazhi Sun, Baohe Yang
In this paper, we describe a method for fabricating dry electrodes for use in recording electroencephalograms (EEGs), which are based on the use of chitosan (Ch), gold (Au) particles, and titanium dioxide (TiO2) nanotube arrays deposited on titanium (Ti) thin sheets. The samples were characterized by scanning electron microscopy, X-ray diffraction, electrochemical impedance spectroscopy, and EEG signal collection. The TiO2 nanotube arrays were grown on the Ti thin sheet by an electrochemical anodic oxidation method...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629050/novel-bilayer-wound-dressing-based-on-electrospun-gelatin-keratin-nanofibrous-mats-for-skin-wound-repair
#6
Chun-Hsu Yao, Chia-Yu Lee, Chiung-Hua Huang, Yueh-Sheng Chen, Kuo-Yu Chen
A bilayer membrane (GKU) with a commercial polyurethane wound dressing as an outer layer and electrospun gelatin/keratin nanofibrous mat as an inner layer was fabricated as a novel wound dressing. Scanning electron micrographs showed that gelatin/keratin nanofibers had a uniform morphology and bead-free structure with average fiber diameter of 160.4nm. 3-(4,5-Dimethylthiazolyl)-2,5-diphenyltetrazolium bromide assay using L929 fibroblast cells indicated that the residues released from the gelatin/keratin composite nanofibrous mat accelerated cell proliferation...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629004/performance-evaluation-of-non-ionic-surfactant-based-tazarotene-encapsulated-proniosomal-gel-for-the-treatment-of-psoriasis
#7
Vure Prasad, Sundeep Chaurasia
The study aims to explore the potential of non-ionic surfactant based proniosomal gel (PNG) in improving the topical delivery of tazarotene by in vitro and in vivo studies. The PNG was prepared using coacervation phase separation method composed of span, stearylamine, cholesterol, and lecithin. The PNG demonstrated favorable vesicle size (3.26±0.22μm) and percent encapsulation efficiency (49.50±2.3%). The PNG was evaluated for viscosity which indicated that the ratio of span:cholesterol:stearylamine (64...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628681/changes-in-self-perceptions-of-photoaging-severity-and-skin-cancer-risk-after-objective-facial-skin-quality-analysis
#8
Yoon-Soo Cindy Bae, Edward Jong Bae, Joyce H Wang, Barbara A Gilchrest
<p>Background: Despite public education efforts, many people at risk for skin cancer do not practice safe sun behaviors.</p> <p>Objective: To determine whether machine-based evaluation of UV-induced alterations (VISIA scan) changes self-assessment of facial photoaging, skin cancer risk, and willingness to improve sun protective habits. In addition, to determine whether VISIA scan analysis reveals differences between those with versus without a history of skin cancer, men versus women, those older than 50 versus less than 50 years of age, and Fitzpatrick skin types I-III versus IV-VI...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28624561/safety-utility-and-clinical-results-of-continuous-intraoperative-electrophysiological-monitoring-in-1-5t-imri-guided-surgery
#9
Martin Breitkopf, Sotirios Bisdas, Marina Liebsch, Felix Behling, Benjamin Bender, Marcos Tatagiba, Constantin Roder
OBJECTIVE: To show that the combined use of intraoperative high-field MRI (iMRI) and electrophysiological monitoring (IOM) is feasible, safe and beneficial for patients. METHODS: The setup, surgical, imaging and clinical results of 110 patients with eloquent intracranial lesions with the combined use of 1.5T iMRI and IOM were analyzed. RESULTS: 187 iMRI scans were performed with IOM needles in place, resulting in a total experience of using more than 4000 electrodes in the iMRI...
June 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28619637/preparation-and-characterization-of-silk-sericin-pva-blend-film-with-silver-nanoparticles-for-potential-antimicrobial-application
#10
Huawei He, Rui Cai, Yejing Wang, Gang Tao, Pengchao Guo, Hua Zuo, Liqun Chen, Xinyu Liu, Ping Zhao, Qingyou Xia
Sericin has great potentials in biomedical applications for its good reactive activity, biocompatibility and biodegradability. However, the undesirable mechanical performance limits its application. Here, we developed a green, facile and economic approach to prepare sericin/polyvinyl alcohol (PVA) blend film. Further, silver nanoparticles (AgNPs) were synthesized in situ on the surface of sericin/PVA film via UV-assisted green synthesis method. Mechanical performance, swelling, mass losing and water retention tests showed the blend film had good mechanical performance, hygroscopicity, water retention capacity and low mass losing ratio...
June 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28619614/rapid-ex-vivo-examination-of-mohs-specimens-using-optical-coherence-tomography
#11
D Rashed, D Shah, A Freeman, R J Cook, C Hopper, C M Perrett
BACKGROUND: Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo. OBJECTIVE: The aim of this prospective ex vivo study was to evaluate the efficacy of OCT in recognising healthy and pathological margins of excised BCC lesions and detecting different BCC subtypes...
June 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28615876/microscopic-investigation-to-determine-the-effect-of-beauveria-bassiana-bals-vuill-and-cymbopogon-citratus-dc-stapf-treatment-on-different-life-stages-of-musca-domestica-l
#12
Sapna Mishra, Peeyush Kumar, Anushree Malik
Microscopic investigation was done to determine the effect of entomopathogenic fungi, Beauveria bassiana and essential oil of Cymbopogon citratus on different life stages of Musca domestica. Scanning electron microscopy investigation of fungal infected larvae showed sluggish movement, rigor, and failure of body to balance in water. Treated larvae also revealed varied level of cuticle shrinkage and extreme dehydration. Surface of B. bassiana infected pupae showed varied stage of mycelial growth, while the cadaver of adult fly was observed to have extensive fungal growth covering their entire body surface...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28614337/dual-axis-optical-coherence-tomography-for-deep-tissue-imaging
#13
Yang Zhao, Will J Eldridge, Jason R Maher, Sanghoon Kim, Michael Crose, Mohamed Ibrahim, Howard Levinson, Adam Wax
We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a rate of 4 frames (B-scans) per second...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28610893/an-insight-into-the-molecular-mechanism-of-the-temporary-enhancement-effect-of-isopulegol-decanoate-on-the-skin
#14
Xiaochang Liu, Meiying Liu, Chao Liu, Peng Quan, Yongshan Zhao, Liang Fang
Chemical enhancers are widely used to facilitate drug permeation in transdermal drug delivery system (TDDS) and the effect of chemical enhancers is desired to be temporary. Though temporary enhancement effect of chemical enhancers has been widely discussed, there is still a lack of knowledge about the molecular mechanism of temporary enhancement effect. Using the skin permeation of flurbiprofen as a probe, the temporary enhancement effect of isopulegol decanoate (ISO-10) was evaluated with in vitro permeation experiment and confocal laser scanning microscopy (CLSM)...
June 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28607794/a-rare-case-of-vasculitis-patched-necrosis-of-cecum-due-to-beh%C3%A3-et-s-disease
#15
Ehsan Shahverdi, Mehdi Morshedi, Faraneh Oraei-Abbasian, Maryam Allahverdi Khani, Roya Khodayarnejad
Isolated cecal necrosis is a rare form of acute ischemic colitis and a rare cause of surgical abdomen. Behçet's disease is a multisystemic autoimmune condition which can induce vasculitis. This can result in cecal necrosis while disease involves colon vessels. We describe a patient with complicated Behçet's disease and ischemic colitis admitted to our hospital. Patient was a 62-year-old female with more accompanying diseases. Histopathologic findings confirmed the diagnosis of ischemic colitis and regarding patient's vision problem and skin lesions, rheumatologic tests were performed which were positive for HLAB5 and HLAB51 suggestive of Behçet's disease; the patient was improved with surgery...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28603514/cutaneous-autonomic-pilomotor-testing-to-unveil-the-role-of-neuropathy-progression-in-early-parkinson-s-disease-capture-pd-protocol-for-a-multicenter-study
#16
Timo Siepmann, Alexandra Pintér, Sylvia J Buchmann, Leonie Stibal, Martin Arndt, Anne Sophie Kubasch, Marie Luise Kubasch, Ana Isabel Penzlin, Elka Frenz, Wagner Zago, Tamás Horváth, Szabolcs Szatmári, Dániel Bereczki, Annamária Takáts, Tjalf Ziemssen, Axel Lipp, Roy Freeman, Heinz Reichmann, Kristian Barlinn, Ben Min-Woo Illigens
BACKGROUND: In Parkinson's disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease. This study aims to assess the association between alpha-synuclein-mediated structural autonomic nerve fiber damage and function in PD, elucidate the role of neuropathy progression during the early disease stages, and test reproducibility and external validity of pilomotor function assessment using quantitative pilomotor axon-reflex test and sudomotor function via quantitative direct and indirect test of sudomotor function...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28602290/a-sensitive-and-disposable-electrochemical-immunosensor-for-detection-of-sox2-a-biomarker-of-cancer
#17
Elif Burcu Aydın, Mustafa Kemal Sezgintürk
A novel, sensitive, disposable indium tin oxide (ITO)-based electrochemical immunosensor was developed firstly for simple, rapid determination of Sex-determining region Y-box 2 (SOX2). SOX2 is a cancer biomarker and used for detecting small cell lung cancer, lung adenocarcinoma, squamous cell carcinoma, skin cancer, prostate cancer, and breast cancer. In this study, a disposable ITO thin film based electrode was used as working electrode for biosensing the interaction between SOX2 antigen and anti-SOX2 antibody...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28602011/differences-in-the-fruit-structure-and-the-location-and-content-of-bioactive-substances-in-viburnum-opulus-and-viburnum-lantana-fruits
#18
Agata Konarska, Marcin Domaciuk
Many Viburnum species are popular ornamental shrubs and, simultaneously, highly valued medicinal plants as a source of many bioactive compounds, including antioxidants. Viburnum bark, flowers, and fruits are widely used in traditional and folk medicine, and the fruits of some species are used as cooking ingredients. The knowledge of the microstructure of Viburnum fruits and the accumulation sites of bioactive substances in these organs is rather poor. Comparative analyses of the microstructure of ripe Viburnum opulus and Viburnum lantana drupes were carried out using light, scanning, and transmission electron microscopes...
June 10, 2017: Protoplasma
https://www.readbyqxmd.com/read/28600601/morphology-and-hydro-sensory-role-of-superficial-neuromasts-in-schooling-behaviour-of-yellow-eyed-mullet-aldrichetta-forsteri
#19
Karen L Middlemiss, Denham G Cook, Alistair R Jerrett, William Davison
The lateral line system is a mechanosensory organ found in all fish species and located on the skin or in subdermal canals. The basic functional units are superficial and canal neuromasts, which are involved in hydrodynamic sensing and cohesion in schooling fish. Yellow-eyed mullet (Aldrichetta forsteri) are an obligate schooling species found commonly in shallow coastal areas of New Zealand and Australia. Schooling is a fundamental part of their behavioural repertoire, yet little is known about the structure or functionality of the lateral line in this species...
June 9, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28600588/-open-reduction-and-internal-fixation-of-lateral-tibial-plateau-fractures-with-free-subchondral-2-7%C3%A2-mm-screws
#20
M Reul, F Johnscher, S Nijs, H Hoekstra
OBJECTIVES: Exact reconstruction of the depressed articular surface and stable subchondral fixation of the lateral tibial plateau (ORIF, "open reduction and internal fixation"). INDICATIONS: Tibial plateau fractures with involvement of the lateral column and depression of the articular surface. CONTRAINDICATIONS: Critical soft tissue. Severe osteoporosis. SURGICAL TECHNIQUE: Supine position, classical anterolateral approach, lateral submeniscal arthrotomy, visualisation of the fracture, osteotomy of the lateral tibial condyle...
June 9, 2017: Operative Orthopädie und Traumatologie
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