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https://www.readbyqxmd.com/read/29040906/a-case-report-of-choledocholithiasis-33-years-after-cholecystectomy
#1
Xane Peters, Gannavarapu Bhargava, Antonio Gangemi
INTRODUCTION: Choledocholithiasis after cholecystectomy is rare and often attributed to surgical clip migration and subsequent nidus formation. PRESENTATION OF CASE: This case demonstrates choledocholithiasis following cholecystectomy with a latency period of 33 years. DISCUSSION: The patient presented with pain of the right upper quadrant (RUQ). Subsequent abdominal-pelvic CT imaging revealed dilation of the common bile duct. Further Endoscopic Retrograde Cholangiopancreatography was indicative of choledocholithiasis...
October 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29040541/placental-nano-vesicles-target-to-specific-organs-and-modulate-vascular-tone-in-vivo
#2
Mancy Tong, Joanna L Stanley, Q Chen, Joanna L James, Peter R Stone, Larry W Chamley
STUDY QUESTION: How do nano-vesicles extruded from normal first trimester human placentae affect maternal vascular function? SUMMARY ANSWER: Placental nano-vesicles affect the ability of systemic mesenteric arteries to undergo endothelium- and nitric oxide- (NO-) dependent vasodilation in vivo in pregnant mice. WHAT IS KNOWN ALREADY: Dramatic cardiovascular adaptations occur during human pregnancy, including a substantial decrease in total peripheral resistance in the first trimester...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040318/rapid-reversal-of-innate-immune-dysregulation-in-blood-of-patients-and-livers-of-humanized-mice-with-hcv-following-daa-therapy
#3
Matthew A Burchill, Justin A Roby, Nanette Crochet, Megan Wind-Rotolo, Amy E Stone, Michael G Edwards, Rachael J Dran, Michael S Kriss, Michael Gale, Hugo R Rosen
RESULTS: First, in patients receiving two different combinations of DAAs, we found that DAAs induced not only rapid viral clearance, but also a re-setting of antiviral immune responses in the peripheral blood. Specifically, we see a rapid decline in the expression of genes associated with chronic IFN stimulation (IFIT3, USP18, IFIT1) as well as a rapid decline in genes associated with inflammation (IL1β, CXCL10, CXCL11) in the peripheral blood that precedes the complete removal of virus from the blood...
2017: PloS One
https://www.readbyqxmd.com/read/29040206/the-life-saving-effect-of-adenosine-lidocaine-and-magnesium-cocktail-during-hypovolemic-shock-one-stone-three-birds
#4
Lusha Xiang, Harold G Klemcke, Kathy L Ryan
No abstract text is available yet for this article.
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29040188/phagocytosis-of-extracellular-vesicles-extruded-from-the-placenta-by-ovarian-cancer-cells-inhibits-growth-of-the-cancer-cells
#5
Qi Chen, Victoria Rutten, Wei-Tzu Cheng, Mancy Tong, Jia Wei, Peter Stone, Lai-Ming Ching, Lawrence W Chamley
OBJECTIVE: Ovarian cancer is a common gynecological cancer, and parity is negatively associated with the incidence of this disease. This negative association is hypothesized to be due in part to shifting the balance of estrogen and progesterone toward more progesterone and reduced ovulation during pregnancy. However, studies suggested that parity is also associated with estrogen-independent gynecological cancers suggesting balance of hormones may not be the only protective factor. Extracellular vesicles (EVs) play an important role in cell-to-cell communication in physiological and pathological conditions...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29036464/the-mimic-code-repository-enabling-reproducibility-in-critical-care-research
#6
Alistair E W Johnson, David J Stone, Leo A Celi, Tom J Pollard
Objective: Lack of reproducibility in medical studies is a barrier to the generation of a robust knowledge base to support clinical decision-making. In this paper we outline the Medical Information Mart for Intensive Care (MIMIC) Code Repository, a centralized code base for generating reproducible studies on an openly available critical care dataset. Materials and Methods: Code is provided to load the data into a relational structure, create extractions of the data, and reproduce entire analysis plans including research studies...
September 27, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29036296/unintended-adverse-consequences-of-a-clinical-decision-support-system-two-cases
#7
Erin G Stone
Many institutions have implemented clinical decision support systems (CDSSs). While CDSS research papers have focused on benefits of these systems, there is a smaller body of literature showing that CDSSs may also produce unintended adverse consequences (UACs). Detailed here are 2 cases of UACs resulting from a CDSS. Both of these cases were related to external systems that fed data into the CDSS. In the first case, lack of knowledge of data categorization in an external pharmacy system produced a UAC; in the second case, the change of a clinical laboratory instrument produced the UAC...
September 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29036000/unilateral-submandibular-gland-atrophy-and-sialolithiasis-diagnosed-on-99mtc-mibi-spect-ct-in-a-patient-with-primary-hyperparathyroidism
#8
Puskar Pattanayak, Prasanna Santhanam, Mehrbod Som Javadi, Lilja B Solnes, Steven P Rowe
A variety of sequelae of elevated calcium levels are encountered in patients with underlying primary hyperparathyroidism, including stone formation such as calculi in the urinary tract and sialoliths in the salivary glands and ducts. We present a case of a 54-year-old woman with fatigue, myalgia, and poor concentration who was found to have hypercalcemia (corrected calcium, 11.2 mg/dL) and elevated parathyroid hormone level (112 pg/mL), laboratory values consistent with primary hyperparathyroidism. She underwent evaluation with a Tc-MIBI parathyroid SPECT scan that included x-ray CT acquisitions for anatomical localization and attenuation correction...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29035699/risk-factors-for-complications-of-intraoral-removal-of-submandibular-sialoliths
#9
Sung Hwa Dong, Seok Hyun Kim, Jeon Gang Doo, Ah Ra Jung, Young Chan Lee, Young-Gyu Eun
PURPOSE: Intraoral removal of submandibular sialoliths is a surgical technique for the treatment of sialolithiasis and is reported to have excellent outcomes. The aim of this study was to determine the risk factors leading to complications of this procedure. PATIENTS AND METHODS: The medical records of 200 patients who had undergone intraoral removal of sialoliths from January 2006 through June 2015 were retrospectively reviewed. A telephone survey was used to check postoperative symptoms...
September 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29035592/returners-exhibit-greater-jumping-performance-improvements-during-a-peaking-phase-compared-to-new-players-on-a-volleyball-team
#10
Caleb D Bazyler, Satoshi Mizuguchi, Ashley A Kavanaugh, John J McMahon, Paul Comfort, Michael H Stone
PURPOSE: To determine if jumping performance changes during a peaking phase differed between returners and new players in a female collegiate volleyball team and to determine which variables best explained the variation in performance changes. METHODS: Fourteen volleyball players were divided into two groups: returners (n=7) and new players (n=7) who completed a 5-week peaking phase prior to conference championships. Players were tested at baseline prior to the pre-season on measures of vastus lateralis cross-sectional area using ultrasonography, estimated back squat one repetition maximum (1-RM), and countermovement jump height (JH) and relative peak power (PPa) on a force platform...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29035474/which-is-the-best-way-to-treat-a-stone-on-a-flexible-ureterorrenoscopy-opinion-dusting
#11
EDITORIAL
Antonio Correa Lopes
No abstract text is available yet for this article.
September 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29035473/which-is-the-best-way-to-treat-a-stone-on-a-flexible-ureterorrenoscopy-opinion-fragmentation
#12
EDITORIAL
Alex Meller
No abstract text is available yet for this article.
September 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29035305/nir-rapid-assessments-of-blumea-balsamifera-ai-na-xiang-in-china
#13
Fu-Lai Yu, Na Zhao, Zhi-Sheng Wu, Mei Huang, Dan Wang, Ying-Bo Zhang, Xuan Hu, Xiao-Lu Chen, Lu-Qi Huang, Yu-Xin Pang
Blumea balsamifera (Ai-na-xiang) is used as an important plant source of natural borneol, which is widely used in the pharmaceutical industry. The aim of this study was to establish the methods based on near infrared (NIR) spectroscopy for determining the geographical origin of B. balsamifera, as well as developing a method for the quantitative rapid analysis of the active pharmaceutical ingredients (APIs). A total of 109 samples were collected from China in 2013 and arbitrarily divided into calibration and prediction sets using the Kennard-Stone algorithm...
October 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29034588/clinical-and-demographic-differences-between-patients-with-manic-depressive-and-schizophrenia-spectrum-psychoses-presenting-to-early-intervention-services-in-london
#14
Adisha Kapila, Helen L Fisher, Sonia Johnson, Barnaby Major, Nikola Rahaman, John Joyce, Nick Chamberlain-Kent, Jo Lawrence, Allan H Young, James M Stone
AIM: To investigate the relationship between the presenting clinical and demographic characteristics in first-episode psychosis (FEP) patients with their clinical diagnostic grouping 1 year later. METHODS: Data from 1014 first-presentation psychosis patients from seven London-based Early Intervention Services were extracted from the MiData audit database. Associations between clinical and demographic measures at presentation and clinical diagnosis made at 1 year were assessed with analysis of variance (ANOVA) and Chi-square tests...
October 15, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29034366/a-phase-2-study-incorporating-sorafenib-into-the-chemotherapy-for-older-adults-with-flt3-mutated-acute-myeloid-leukemia-calgb-11001
#15
Geoffrey L Uy, Sumithra J Mandrekar, Kristina Laumann, Guido Marcucci, Weiqiang Zhao, Mark J Levis, Heidi D Klepin, Maria R Baer, Bayard L Powell, Peter Westervelt, Daniel J DeAngelo, Wendy Stock, Ben Sanford, William G Blum, Clara D Bloomfield, Richard M Stone, Richard A Larson
The Cancer and Leukemia Group B (CALGB), now part of the Alliance for Clinical Trials in Oncology, conducted a multicenter, single-arm, phase 2 study in patients ≥60 years with FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML). In this study, sorafenib was added to daunorubicin and cytarabine-based induction and consolidation chemotherapy and was also continued for 12 months of maintenance therapy. The primary end point of the study was overall survival (OS) at 1 year in the FLT3 internal tandem duplication (FLT3-ITD) cohort...
January 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29034365/ethnicity-sex-and-age-are-determinants-of-red-blood-cell-storage-and-stress-hemolysis-results-of-the-reds-iii-rbc-omics-study
#16
Tamir Kanias, Marion C Lanteri, Grier P Page, Yuelong Guo, Stacy M Endres, Mars Stone, Sheila Keating, Alan E Mast, Ritchard G Cable, Darrell J Triulzi, Joseph E Kiss, Edward L Murphy, Steve Kleinman, Michael P Busch, Mark T Gladwin
Genetic polymorphisms in blood donors may contribute to donor-specific differences in the survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic variability is anticipated to be high in donors with racial admixture from malaria endemic regions such as Africa and Asia. The purpose of this study was to test the hypothesis that donor genetic background, reflected by sex and self-reported ethnicity, significantly modulates RBC phenotypes in storage. High throughput hemolysis assays were developed and used to evaluate stored RBC samples from 11 115 African American, Asian, white, and Hispanic blood donors from 4 geographically diverse regions in the United States...
June 27, 2017: Blood Advances
https://www.readbyqxmd.com/read/29034340/titanium-addition-influences-antibacterial-activity-of-bioactive-glass-coatings-on-metallic-implants
#17
Omar Rodriguez, Wendy Stone, Emil H Schemitsch, Paul Zalzal, Stephen Waldman, Marcello Papini, Mark R Towler
In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29034196/protective-effect-of-ethyl-acetate-fraction-of-biophytum-sensitivum-extract-against-sodium-oxalate-induced-urolithiasis-in-rats
#18
Anil T Pawar, Niraj S Vyawahare
The methanolic whole plant extract of Biophytum sensitivum (gǎnyìng cǎo) has been found to possess antiurolithiatic effect. The present study was undertaken to evaluate the antiurolithiatic effect of some fractions of methanolic whole plant extract of B. sensitivum (MBS) in rats as a step toward activity-directed isolation of antiurolithiatic component. The MBS was successively extracted with dichloromethane, ethyl acetate, ethanol and water to obtain fractions. Sodium oxalate (70 mg/kg, i.p.) was administered to rats for seven days to develop calcium oxalate urolithiasis...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033769/ascending-cholangitis-due-to-heavy-lifting
#19
M J Bakkum, R J L F Loffeld
Gallstone disease is the most common risk factor for cholangitis. In an anatomically normal bile duct system, cholangitis does not occur without the presence of stones. Endoscopic retrograde cholangiography with papillotomy and stone extraction is a well-established curative therapy for gallstones in the common bile duct. More important, papillotomy prevents recurrent episodes. The present case report describes a 73-year-old male with recurring cholangitis in a clear bile duct system after previous papillotomy...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033767/hemorrhagic-cholecystitis-in-a-patient-on-maintenance-dialysis
#20
Masayuki Shishida, Masahiro Ikeda, Nozomi Karakuchi, Kosuke Ono, Naofumi Tsukiyama, Manabu Shimomura, Koichi Oishi, Kazuaki Miyamoto, Kazuhiro Toyota, Seiji Sadamoto, Tadateru Takahashi
The present paper describes a case of hemorrhagic cholecystitis in a patient on maintenance dialysis. The patient presented with right upper quadrant abdominal pain. Computed tomography revealed swelling of the gallbladder, high- and isodensity contents of the gallbladder, and high-density stone in the gallbladder neck. He was hospitalized for suspected acute cholecystitis. After hospitalization, his levels of total bilirubin, aspartate aminotransferase, and alanine aminotransferase increased. T2-weighted magnetic resonance imaging showed low-intensity contents expanded to include a wide area from the common bile duct to the cystic duct and gallbladder neck...
May 2017: Case Reports in Gastroenterology
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