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Anesthesia

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https://www.readbyqxmd.com/read/28548837/the-role-of-the-hydroxyl-group-in-propofol-protein-target-recognition-insights-from-oniom-studies
#1
Ling Qiu, Jianguo Lin, Qingzhu Liu, Shanshan Wang, Gaochao Lv, Ke Li, Haiming Shi, Zhengkun Huang, Edward J Bertaccini
Propofol (PFL, 1-hydroxyl-2,6-diisopropylbenzene) is currently used widely as one of the most well-known intravenous anesthetics to relieve surgical suffering, but its mechanism of action is not yet clear. Previous experimental studies have demonstrated that the hydroxyl group of PFL plays a dominant role in the molecular recognition of PFL with receptors that lead to hypnosis. To further explore the mechanism of anesthesia induced by PFL in the present work, the exact binding features and interaction details of PFL with three important proteins, human serum albumin (HSA), the pH-gated ion channel from Gloeobacter violaceus (GLIC) and horse spleen apoferritin (HSAF), were investigated systematically by using a rigorous three-layer ONIOM(M06-2X/6-31+G*:PM6:AMBER) method...
May 26, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28547209/anesthesia-for-myelomeningocele-surgery-in-fetus
#2
Juan Carlos Devoto, Juan Luis Alcalde, Felipe Otayza, Waldo Sepulveda
BACKGROUND: Administering anesthesia for prenatal repair of myelomeningocele reveals several issues that are unique to this new form of treatment. This includes issues such as fetal well-being, surgical conditions and monitoring, among others. Exploring, analyzing, and understanding the different variables that are involved will help us reduce the high level of risk associated with this surgery. OBJECTIVE: This review provides a systematic approach to the issues that are faced by anesthesiologists during fetal surgery...
May 25, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28547078/infiltrative-local-anesthesia-with-articaine-is-equally-as-effective-as-inferior-alveolar-nerve-block-with-lidocaine-for-the-removal-of-erupted-molars
#3
J Venkat Narayanan, Prashanthi Gurram, Radhika Krishnan, Veerabahu Muthusubramanian, V Sadesh Kannan
AIM: The aim of this study is to assess the efficacy of 4% articaine with 1:100,000 adrenaline given as buccal and lingual infiltration in adult patients undergoing erupted mandibular first and second molar teeth extraction versus inferior alveolar nerve block technique using 2% lignocaine with 1:80,000 adrenaline. MATERIALS AND METHODS: A total of 100 patients undergoing extraction of mandibular posterior teeth were divided into two equally matched groups for the study, out of which 50 patients were given 4% articaine with 1:100,000 adrenaline as buccal and lingual infiltration and 50 patients were given 2% lignocaine with 1:80,000 adrenaline using classic direct inferior alveolar nerve block with lingual and buccal nerve block...
May 25, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28546920/ocular-penetration-of-topically-applied-1-tigecycline-in-a-rabbit-model
#4
Yasar Sakarya, Rabia Sakarya, Muammer Ozcimen, Sertan Goktas, Serap Ozcimen, Ismail Alpfidan, Ismail Senol Ivacık, Erkan Erdogan, Servet Cetinkaya, Abdulkadir Bukus
AIM: To evaluate ocular penetration of topically applied 1% tigecycline. METHODS: Forty-two New Zealand White rabbits were divided into 3 groups. A 50 µL drop of 1% tigecycline was administered in group 1. In groups 2 and 3, the drop was administered every 15min for 60min (keratitis protocol). Aqueous humor samples in groups 1 and 2 were collected under general anesthesia at 15, 30, 45, 60, 120, and 180min after the last drop. All animals in group 3 were euthanatized...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546816/effects-of-intrathecal-opioids-use-in-cesarean-section-on-breastfeeding-and-newborns-weight-gaining
#5
Fardin Yousefshahi, Fatemeh Davari-Tanha, Atabak Najafi, Mahbod Kaveh, Mohsen Rezaei Hemami, Patricia Khashayar, Mohammad Anbarafshan
Objective: To assess the association between intrapartum intrathecal opioid use and breastfeeding and weight gain following cesarean section. Materials and methods: The prospective double-blinded study was conducted on term pregnant women, undergoing elective cesarean section under spinal anesthesia. They divided into two groups. In the first group, intrathecal Morphine was used to achieve analgesia during or after the operation. The remainder divided into two subgroups, those who did not receive any opioid or those received systemic opioids...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28546768/effectiveness-of-various-formulations-of-local-anesthetics-and-additives-for-topical-anesthesia-a-prospective-randomized-double-blind-placebo-controlled-study
#6
Christian Weilbach, Christian Hoppe, Matthias Karst, Michael Winterhalter, Konstantinos Raymondos, Arthur Schultz, Niels Rahe-Meyer
BACKGROUND: Topical anesthesia is used to control pain associated with many procedures in medicine. Today, the product most commonly applied for topical anesthesia in Germany is EMLA(®) (lidocaine/prilocaine). However, since prilocaine is a methemoglobin-inducing agent, there are limitations to its use, especially in neonates and infants. The aim of this study was to evaluate the effect of prilocaine and lidocaine as well as propylene glycol, a penetration enhancer, and trometamol, a buffer substance, in anesthetic creams...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28546697/erratum-comparison-of-olive-tipped-and-conventional-steven-s-cannula-for-sub-tenon-ophthalmic-anesthesia
#7
(no author information available yet)
[This corrects the article on p. 307 in vol. 23, PMID: 27994394.].
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546695/retinal-vascular-occlusion-secondary-to-retrobulbar-injection-case-report-and-literature-review
#8
Dhaivat Vasavada, Prabu Baskaran, Seema Ramakrishnan
Retrobulbar injection has been widely practiced as a technique of ocular anesthesia for many decades. Nevertheless, the technique is not free from complications. Vascular occlusion secondary to retrobulbar injection is rare but can be vision threatening. We report a case series of two such patients who presented with poor vision following retrobulbar injection. Fundus showed pale retina with cherry red spot suggestive of central retinal artery occlusion in case 1 and pale disc with sclerosed vessels and multiple superficial hemorrhages suggestive of a combined occlusion of retinal artery and vein in case 2...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546670/cholecystectomy-and-hysterectomy-a-least-invasive-approach
#9
Shirish Sheth, Tehemton Udwadia, Dipti Shende
OBJECTIVE: The study is to promote the least invasive approach that combines cholecystectomy and hysterectomy at the same operative sitting so as to provide maximum benefits to women. METHOD: A series of 45 women between 40 and 75 years age from year 2001 to 2014 from the private practice of author and colleague surgeons in Mumbai were in need of hysterectomy as well as cholecystectomy for gynecological indication and symptomatic gallstones, respectively. Cholecystectomy was performed laparoscopically by general surgeon and was combined with hysterectomy with or without bilateral salpingo-oophorectomy (BSO) via vaginal route by gynecologist...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28546664/early-maternal-feeding-versus-traditional-delayed-feeding-after-cesarean-section-a-pilot-study
#10
Sukesh Kumar Kathpalia
BACKGROUND: Cesarean section is on the rise all over the world; it has become a safe surgery due to better anesthesia, asepsis, blood transfusion and antibiotics. Traditionally, the patients are kept nil orally till they pass flatus. This study was performed to find out acceptance and tolerability of early feeding, its side effects and complications if any. METHODS: This comparative study was conducted in a service hospital. There were two groups of 70 cases each where one was administered early feeding and the second group was put on standard delayed feeding as is traditionally done in most of the hospitals...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28546120/local-anesthesia-for-endovascular-treatment-of-unruptured-intracranial-aneurysms-feasibility-safety-and-periprocedural-complications
#11
Jihye Song
OBJECTIVE: The aim of the study is to report the feasibility, safety and outcomes associated with endovascular treatment (EVT) of unruptured intracranial aneurysms (UIA) under local anesthesia (LA). METHODS: Between March 2011 and December 2016, 184 consecutive patients with 198 UIA were treated with coil embolization under LA at the author's center. The data about medical comorbidities according to American Society of Anesthesiologists (ASA) grade, procedural details, and clinical and radiographic outcomes were reviewed...
May 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28546088/extracorporeal-shock-wave-lithotripsy-management-of-renal-stones-in-children-does-anesthesia-affect-the-treatment-outcomes-on-an-age-based-manner
#12
Murat Tuncer, Banu Çevik, Bilal Eryıldırım, Gökhan Faydacı, Kemal Sarıca
OBJECTIVE: To evaluate beneficial effect of anaesthesia on extracorporeal shock wave lithotripsy (SWL) in children older than nine years. PATIENTS AND METHODS: A total of 61 children (aging between 9-17 years) treated with SWL for renal stones were included. Depending on the use of general anesthesia, children were divided into two groups; (Group 1, n=27) Cases treated with SWL under anesthesia and (Group 2, n=34) SWL without anesthesia. Patients in both groups were comparatively evaluated with respect to treatment related (stone size, stone laterality, stone location, mean number of sessions, mean number of shock waves applied, residual fragments size, stone free rate (SFR), clinically significant residual fragment complications and need of additional intervention) parameters...
May 22, 2017: Urology
https://www.readbyqxmd.com/read/28546014/-anesthetic-requirements-measured-by-bilateral-bispectral-analysis-and-femoral-blockade-in-total-knee-arthroplasty
#13
Maylin Koo, Javier Bocos, Antoni Sabaté, Vinyet López, Carmina Ribes
BACKGROUND AND OBJECTIVES: A continuous peripheral nerve blockade has proved benefits on reducing postoperative morphine consumption; the combination of a femoral blockade and general anesthesia on reducing intraoperative anesthetic requirements has not been studied. The objective of this study was to determine the relevance of timing in the performance of femoral block to intraoperative anesthetic requirements during general anesthesia for total knee arthroplasty. METHODS: A single-center, prospective cohort study on patients scheduled for total knee arthroplasty, were sequentially allocated to receive 20mL of 2% mepivacaine throughout a femoral catheter, prior to anesthesia induction (Preoperative) or when skin closure started (Postoperative)...
May 22, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28546013/-comparison-of-different-methods-of-nasogastric-tube-insertion-in-anesthetized-and-intubated-patients
#14
Ali Sait Kavakli, Nilgun Kavrut Ozturk, Arzu Karaveli, Asuman Arslan Onuk, Lutfi Ozyurek, Kerem Inanoglu
BACKGROUND: Nasogastric tube insertion may be difficult in anesthetized and intubated patients with head in the neutral position. Several techniques are available for the successful insertion of nasogastric tube. The primary aim of this study was to investigate the difference in the first attempt success rate of different techniques for insertion of nasogastric tube. Secondary aim was to investigate the difference of the duration of insertion using the selected technique, complications during insertion such as kinking and mucosal bleeding...
May 22, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28546012/-a-prospective-randomized-double-blinded-control-study-on-comparison-of-tramadol-clonidine-and-dexmedetomidine-for-post-spinal-anesthesia-shivering
#15
Rajagopalan Venkatraman, Krishnamoorthy Karthik, Anand Pushparani, Annadurai Mahalakshmi
INTRODUCTION: Shivering, a common intraoperative problem under spinal anesthesia increases the oxygen consumption considerably and is uncomfortable and distressing to the patient, anesthesiologist as well as surgeon. The present study was designed to explore the effectiveness of tramadol, clonidine and dexmedetomidine in the treatment of post spinal anesthesia shivering and to look for their adverse effects. METHODS: This prospective, randomized, double blinded control study was done on 90 patients who developed shivering under spinal anesthesia...
May 22, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28546011/-internal-carotid-artery-dissection-after-laparoscopic-surgery
#16
Esperanza Martín-Mateos, Manuel Ángel Gómez-Ríos, Enrique Freire-Vila
Headache is a common symptom in the postoperative period and may be attributable to, dehydration, sleep deprivation, intentional or inadvertent dural puncture during a neuraxial anesthesia technique, from an inhaled anesthetic agent, or from specific surgical procedures, among other etiologies. However, more serious, uncommon and life-threatening conditions as carotid artery dissection can be associated with severe neurologic sequelae in otherwise young, healthy patients. For these reasons, clinicians involved with postoperative patients should be familiar with the presentation and management strategies for this complication...
May 22, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28545825/the-effect-of-anesthetic-drug-choice-on-accuracy-of-high-definition-oscillometry-in-laterally-recumbent-horses
#17
Tanya Duke-Novakovski, Barbara Ambros, Cindy Feng, Anthony P Carr
OBJECTIVE: To determine the accuracy of high-definition oscillometry (HDO) for arterial pressure measurement during injectable or inhalation anesthesia in horses. STUDY DESIGN: Prospective, clinical study. ANIMALS: Twenty-four horses anesthetized for procedures requiring lateral recumbency. METHODS: Horses were premedicated with xylazine, and anesthesia induced with diazepam-ketamine. Anesthesia was maintained with xylazine-ketamine-guaifenesin combination [TripleDrip (TD; n = 12) or isoflurane (ISO; n = 12)]...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28545733/simultaneous-on-line-monitoring-of-propofol-and-sevoflurane-in-balanced-anesthesia-by-direct-resistive-heating-gas-chromatography
#18
Hao Dong, Feng Jiang Zhang, Fu Yuan Wang, Ying Ying Wang, Jing Guo, G M Kanhar, Jing Chen, Jun Liu, Chen Zhou, Min Yan, Xing Chen
In balanced anesthesia, sevoflurane and propofol are often used in combination to achieve a better anesthetic effect. However, methods for on-line monitoring of concentrations of the two anesthetics in patients are still rare in clinical. This study proposed a non-invasive method utilizing a fast gas chromatograph combined with a surface acoustic wave sensor (Fast GC-SAW) to simultaneously on-line monitor sevoflurane and propofol in patients' exhaled gas. By using the direct resistive heating capillary column, the single detection time of Fast GC-SAW system was significantly shortened to 90s, as well as the size reduced to (40cm×30cm×20cm)...
May 2, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28545460/intraperitoneal-implantation-of-life-long-telemetry-transmitters-in-three-rehabilitated-harbor-seal-pups
#19
Markus Horning, Martin Haulena, Justin F Rosenberg, Chad Nordstrom
BACKGROUND: Pinnipeds, including many phocid species of concern, are inaccessible and difficult to monitor for extended periods using conventional, externally attached telemetry devices that are shed during the annual molt. Archival satellite transmitters were implanted intraperitoneally into three stranded Pacific harbor seal pups (Phoca vitulina richardii) that completed rehabilitation, to evaluate the viability of this surgical technique for the deployment of life long telemetry devices in phocids...
May 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28545280/-impacts-of-early-metoprolol-intervention-on-connexin-43-and-phosphorylated-connexin-43-expression-in-rabbits-with-experimental-myocardial-infarction
#20
M Zhou, Q Lu, J Q Jiang, Z N Chen, Z G Gong, Z G Li, W W Fu, S F Ding
Objective: To investigate the early intervention effects of metoprolol on connexin 43(Cx43) and phosphorylated Cx43 (p-Cx43) expression in rabbits with post myocardial infarction. Methods: A total of 24 adult male New Zealand white rabbits were divided into sham group (n=6), early treatment group(n=6), routine treatment group(n=6), and myocardial infarction group(n=6) with a randomized block design blocked by weight. Myocardial infarction was induced by left anterior descending coronary artery (LAD) ligation...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
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