Shuangpiao Deng, Kaixin Ou, Chenyu Zhang, Daojing Yuan, Xiaowen Cai, Fengtan Li, Xuetao Wang, Jing Yin, Chuanshan Xu, Yanli Li, Teng Gong
Bacterial infection and immune imbalance are the primary culprits behind chronic wounds in individuals with diabetes, impeding the progression of damaged tissues towards normal healing. To achieve a harmonious balance between pro- and anti-inflammation within these infected areas, herein, we propose a one-two punch strategy for on-demand therapy of diabetes-infected wounds, utilizing an azithromycin (AZM)-hybrid nanocomposite termed GOx@Fex Sy /AZM. During the infective stage, the nanocomposite facilitates the production of ROS, coupled with the burst release of AZM and H2 S gas, effectively dismantling biofilms and achieving rapid sterilization...
April 19, 2024: Acta Biomaterialia