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https://www.readbyqxmd.com/read/28350810/risky-sexual-practice-and-associated-factors-among-hiv-positive-adults-attending-anti-retroviral-treatment-clinic-at-gondar-university-referral-hospital-northwest-ethiopia
#1
Abiyot Abeje Molla, Abebaw Addis Gelagay
INTRODUCTION: Risky sexual practice among people living with HIV/AIDS is a public health concern because of the risk of transmission of the virus to sero-discordant partner/s. There is also the risk of re-infection with new, drug resistant viral strains between sero-concordant partners. However, there is lack of information on risky sexual practices among HIV positive adults. Therefore, this study aimed to assess risky sexual practice and associated factors among adult HIV positive clients at Gondar University Referral Hospital, Northwest Ethiopia, 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28350802/impact-of-lopinavir-ritonavir-exposure-in-hiv-1-infected-children-and-adolescents-in-madrid-spain-during-2000-2014
#2
Patricia Rojas Sánchez, Luis Prieto, Santiago Jiménez De Ory, Elisa Fernández Cooke, Maria Luisa Navarro, José Tomas Ramos, África Holguín
BACKGROUND: The most-used protease-inhibitor in children is Lopinavir-ritonavir (LPV/r), which provides durable suppression of viral load and increases CD4+T-counts. This study describes the virological outcome of the HIV-1-infected paediatric population exposed to LPV/r during 15 years in Spain. METHODOLOGY: Patients from the Madrid Cohort of HIV-1-infected-children and adolescents exposed to LPV/r as different line therapy during 2000-2014 were selected. The baseline epidemiological-clinical features, viral suppression, changes in CD4+T-CD8+T cell counts and drug susceptibility were recorded before and during LPV/r exposure...
2017: PloS One
https://www.readbyqxmd.com/read/28350724/prevalence-and-predictors-of-unsatisfactory-anal-cytology-tests-in-a-cohort-of-gay-and-bisexual-men-in-sydney-australia-baseline-findings-from-the-study-of-the-prevention-of-anal-cancer-spanc
#3
David J Templeton, Jennifer M Roberts, I Mary Poynten, Carmella Law, Richard J Hillman, Annabelle Farnsworth, Christopher K Fairley, Sepehr N Tabrizi, Suzanne M Garland, Andrew E Grulich, Fengyi Jin
Anal cytology has been suggested as a screening test for the anal cancer precursor high-grade squamous intraepithelial lesion (HSIL). We aimed to assess the prevalence and predictors of initial unsatisfactory anal cytology tests ('unsats'). The Study of the Prevention of Anal Cancer is a natural history study of anal human papillomavirus (HPV) and precancerous lesions among gay and bisexual men (GBM) of at least 35 years in Sydney, Australia. At each study visit, an anal swab is collected for cytological testing...
May 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28346804/hepatitis-b-and-c-virus-infections-among-human-immunodeficiency-virus-infected-people-who-inject-drugs-in-lahore-pakistan
#4
Sana Mansha, Muhammad Imran, Amir Miraj Ul Hussain Shah, Muhsin Jamal, Fayyaz Ahmed, Muhammad Atif, Muhammmad Saleem, Sher Zaman Safi, Zareen Fatima, Ahmed Bilal Waqar
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major cause of the global burden of hepatitis. One of the main routes of transmission for both viruses is through exposure to infected blood, which includes sharing blood-contaminated syringes and needles. Human immunodeficiency virus (HIV) attacks the immune system and results in acquired immune deficiency syndrome and opportunistic infections. The objective of this study was to assess the epidemiology of HBV and HCV infections among HIV-infected people who inject drugs (PWID)...
March 27, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28346597/association-of-risk-of-viremia-immunosuppression-serious-clinical-events-and-mortality-with-increasing-age-in-perinatally-human-immunodeficiency-virus-infected-youth
#5
Anne M Neilan, Brad Karalius, Kunjal Patel, Russell B Van Dyke, Mark J Abzug, Allison L Agwu, Paige L Williams, Murli Purswani, Deborah Kacanek, James M Oleske, Sandra K Burchett, Andrew Wiznia, Miriam Chernoff, George R Seage, Andrea L Ciaranello
Importance: As perinatally human immunodeficiency virus-infected youth (PHIVY) in the United States grow older and more treatment experienced, clinicians need updated information about the association of age, CD4 cell count, viral load (VL), and antiretroviral (ARV) drug use with risk of opportunistic infections, key clinical events, and mortality to understand patient risks and improve care. Objective: To examine the incidence or first occurrence during follow-up of key clinical events (including Centers for Disease Control and Prevention stage B [CDC-B] and stage C [CDC-C] events) and mortality among PHIVY stratified by age, CD4 cell count, and VL and ARV status...
March 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28343818/comparative-performances-of-serologic-and-molecular-assays-for-detecting-htlv-1-and-htlv-2-in-patients-infected-with-hiv-1
#6
Karoline Rodrigues Campos, Maria Gisele Gonçalves, Nadia Aparecida Costa, Adele Caterino-de-Araujo
The present study evaluated several techniques currently available (commercial kits and in-house assays) for diagnosing human T lymphotropic viruses types 1 and 2 (HTLV-1/-2) in two groups of patients enrolled at HIV/AIDS specialized care services in São Paulo: Group 1 (G1), n=1608, 1237 male/371 female, median age 44.3 years old, majority using highly active antiretroviral therapy (HAART); G2, n=1383, 930 male/453 female, median age of 35.6 years old, majority HAART naïve. Enzyme immunoassays [(EIA) Murex and Gold ELISA] were employed for HTLV-1/-2 screening; Western blotting (WB), INNO-LIA (LIA), real-time PCR pol (qPCR), and nested-PCR-RFLP (tax) were used to confirm infection...
March 23, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28343351/health-related-quality-of-life-hrqol-and-its-correlates-among-community-recruited-children-living-with-hiv-and-uninfected-children-born-to-hiv-infected-parents-in-west-bengal-india
#7
Aritra Das, Roger Detels, Abdelmonem A Afifi, Marjan Javanbakht, Frank J Sorvillo, Samiran Panda
PURPOSE: Helping children living with HIV (CLH) to attain an optimum quality of life is an important goal for HIV programs around the world. Our principal objectives were to determine the association of HIV infection with different domains of health-related quality of life (HRQoL) among 8- to 15-year-old CLH in India and to compare the HRQoL parameters between CLH and HIV-negative children born to HIV-infected parents ("HIV-affected"). We also assessed whether antiretroviral therapy (ART) and CD4 lymphocyte counts were associated with HRQoL among CLH...
March 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28343255/giving-voice-to-african-thought-in-medical-research-ethics
#8
Godfrey B Tangwa
In this article, I consider the virtual absence of an African voice and perspective in global discourses of medical research ethics against the backdrop of the high burden of diseases and epidemics on the continent and the fact that the continent is actually the scene of numerous and sundry medical research studies. I consider some reasons for this state of affairs as well as how the situation might be redressed. Using examples from the HIV/AIDS and Ebola epidemics, I attempt to show that the marginalization of Africa in medical research and medical research ethics is deliberate rather than accidental...
March 25, 2017: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/28343120/nanoemulgel-using-a-bicephalous-heterolipid-as-a-novel-approach-to-enhance-transdermal-permeation-of-tenofovir
#9
Sanjeev Rambharose, Rahul S Kalhapure, Thirumala Govender
Improvements in permeation enhancement strategies, such as nanoemulsions (NEs) and nanoemulgels (NEGs), have led to a renewed interest in transdermal drug delivery (TDD). This study aimed to investigate the potential of LLA1E, a novel dendritic permeation enhancer, as an oily phase in the development of a NEG for the TDD of tenofovir (TNF). TNF loaded NEs (TNEs) were prepared and analysed for mean globule diameter (MGD), polydispersity index (PDI), zeta potential (ZP) and morphology. NEGs of the TNEs (TNEGs) were prepared and evaluated for ex vivo transdermal permeation efficacy...
March 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28342778/-the-burden-of-fungal-infections-in-algeria
#10
REVIEW
M Chekiri-Talbi, D W Denning
In Algeria, superficial mycoses are very commonly diagnosed. Deep fungal infections are less often observed. Few data from Algeria are found in the literature. We report for the first time the main causes of these diseases in our country and provide burden estimates. We searched for existing data and estimated the incidence and prevalence of fungal diseases based on the population at risk and available epidemiological data. Demographic data were derived from the Service (Office) of the Statistics (ONES), World Health Organization (WHO), The Joint Nations Programme on HIV/AIDS (UNAIDS) and national published reports...
March 22, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28341926/risks-associated-with-antiretroviral-treatment-for-human-immunodeficiency-virus-hiv-qualitative-analysis-of-social-media-data-and-health-state-utility-valuation
#11
Louis S Matza, Karen C Chung, Katherine J Kim, Trena M Paulus, Evan W Davies, Katie D Stewart, Grace A McComsey, Marshall W Fordyce
PURPOSE: Despite benefits of antiretroviral therapies (ART), people with HIV infection have increased risk of cardiovascular disease, kidney disease, and low bone mineral density. Some ARTs increase risk of these events. The purpose of this study was to examine patients' perspectives of these risks and estimate health state utilities associated with these risks for use in cost-utility models. METHODS: Qualitative thematic analysis was conducted to examine messages posted to the POZ/AIDSmeds Internet community forums, focusing on bone, kidney, and cardiovascular side effects and risks of HIV/AIDS medications...
March 24, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28340619/operational-and-implementation-research-within-global-fund-to-fight-aids-tuberculosis-and-malaria-grants-a-situation-analysis-in-six-countries
#12
Sabine Kiefer, Astrid M Knoblauch, Peter Steinmann, Tanja Barth-Jaeggi, Mahnaz Vahedi, Dermot Maher, Jürg Utzinger, Kaspar Wyss
BACKGROUND: Operational/implementation research (OR/IR) is a key activity to improve disease control programme performance. We assessed the extent to which malaria and tuberculosis (TB) grants from the Global Fund to Fight AIDS, Tuberculosis and Malaria ("Global Fund") include support for OR/IR, and discuss the implications of the current Global Fund operating mechanisms for OR/IR support. METHODS: The situation analysis focussed on malaria and TB, while HIV was excluded...
March 24, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28340606/validating-a-self-report-measure-of-hiv-viral-suppression-an-analysis-of-linked-questionnaire-and-clinical-data-from-the-canadian-hiv-women-s-sexual-and-reproductive-health-cohort-study
#13
Allison Carter, Alexandra de Pokomandy, Mona Loutfy, Erin Ding, Paul Sereda, Kath Webster, Valerie Nicholson, Kerrigan Beaver, Robert S Hogg, Angela Kaida
BACKGROUND: We assessed the validity of a self-report measure of undetectable viral load (VL) among women with HIV in British Columbia (BC), Canada. Questionnaire data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study was linked with population-based clinical data from the BC Centre for Excellence in HIV/AIDS. Self-reported undetectable VL was assessed by the question: "What was your most recent VL, undetectable (i.e. <50 copies/mL) or detectable (i.e. ≥50 copies/mL)?" Laboratory measurements of VL <50 copies/mL (closest to/before study visit) were the criterion for validity analyses...
March 24, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28340444/comparative-effectiveness-of-dual-action-versus-single-action-antidepressants-for-the-treatment-of-depression-in-people-living-with-hiv-aids
#14
Jon C Mills, Jeffrey S Harman, Robert L Cook, Nicole M Marlow, Christopher A Harle, R Paul Duncan, Angela M Bengtson, Brian W Pence
BACKGROUND: Depression is the most common psychiatric comorbidity among people living with HIV/AIDS (PLWHA). Little is known about the comparative effectiveness between different types of antidepressants used to treat depression in this population. We compared the effectiveness of dual-action and single-action antidepressants in PLWHA for achieving remission from depression. METHODS: We used data from the Centers for AIDS Research Network of Integrated Clinic Systems to identify 1175 new user dual-action or single-action antidepressant treatment episodes occurring from 2005 to 2014 for PLWHA diagnosed with depression...
March 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340421/cannabis-use-patterns-and-motives-a-comparison-of-younger-middle-aged-and-older-medical-cannabis-dispensary-patients
#15
Nancy A Haug, Claudia B Padula, James E Sottile, Ryan Vandrey, Adrienne J Heinz, Marcel O Bonn-Miller
INTRODUCTION: Medical cannabis is increasingly being used for a variety of health conditions as more states implement legislation permitting medical use of cannabis. Little is known about medical cannabis use patterns and motives among adults across the lifespan. METHODS: The present study examined data collected at a medical cannabis dispensary in San Francisco, California. Participants included 217 medical cannabis patients who were grouped into age-defined cohorts (younger: 18-30, middle-aged: 31-50, and older: 51-72)...
March 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28339668/immunogenicity-of-a-booster-dose-of-quadrivalent-meningococcal-conjugate-vaccine-in-previously-immunized-hiv-infected-children-and-youth
#16
Meredith G Warshaw, George K Siberry, Paige Williams, Michael D Decker, Patrick Jean-Philippe, Jorge Lujan-Zilbermann
Background.: The US Advisory Committee on Immunization Practices recommends a booster dose of quadrivalent meningococcal conjugate vaccine (MCV4) after initial immunization for patients at high risk for meningococcal infection. Methods.: The International Maternal Pediatric Adolescents AIDS Clinical Trials (IMPAACT) P1065 trial evaluated the use of MCV4 in human immunodeficiency virus (HIV)-infected children and youth. The final step of this trial was an open-label study of an MCV4 booster dose 3...
February 18, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339344/correlation-of-leptin-adiponectin-and-resistin-levels-in-different-types-of-lipodystrophy-in-hiv-aids-patients
#17
Danica Srdic, Al Musalhi Khawla, Ivan Soldatovic, Jelena Nikolic, Djordje Jevtovic, Devaki Nair, Gordana Dragovic
BACKGROUND: Leptin, adiponectin, and resistin may play an important role in the development of lipodystrophy (LD) in HIV/AIDS patients. The aim of this study was to correlate levels of leptin, adiponectin, and resistin between HIV/AIDS patients with LD and without lipodystrophy (non-LD), as well as between subgroups of LD [lipoatrophy (LA), lipohypertrophy (LH), and mixed fat redistribution (MFR)] and non-LD patients. METHODS: Cross-sectional study of 66 HIV/AIDS patients...
April 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28337191/toxoplasma-gondii-infection-in-immunocompromised-patients-a-systematic-review-and-meta-analysis
#18
Ze-Dong Wang, Huan-Huan Liu, Zhan-Xi Ma, Hong-Yu Ma, Zhong-Yu Li, Zhi-Bin Yang, Xing-Quan Zhu, Bin Xu, Feng Wei, Quan Liu
Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infection in HIV/AIDS patients, cancer patients, and transplant recipients, and meta-analyses were conducted to calculate overall estimated prevalence and ORs using random or fixed-effects models. Totally, 72 eligible studies were included...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28335616/predictors-of-cd4-health-and-viral-suppression-outcomes-for-formerly-homeless-people-living-with-hiv-aids-in-scattered-site-supportive-housing
#19
Elizabeth A Bowen, James Canfield, Suzanne Moore, Midge Hines, Brent Hartke, Chrissy Rademacher
Stable housing is key to improving health outcomes for people living with HIV/AIDS. Though many formerly homeless HIV positive individuals reside in supportive housing, little research has examined biometric HIV health outcomes for residents of these programs. Through a community-based research partnership, this study analyzed secondary data from a Shelter Plus Care supportive housing program in Cincinnati, Ohio to examine the likelihood of participants achieving a healthy CD4 count (>500 cells/mm(3)) and viral suppression (viral load <200 copies/mL) while in supportive housing and to identify participant characteristics associated with these outcomes...
March 23, 2017: AIDS Care
https://www.readbyqxmd.com/read/28335444/hiv-education-and-welfare-services-in-primary-care-an-empirical-model-of-integration-in-brazil-s-unified-health-system
#20
Rahbel Rahman, Rogério M Pinto, Melanie M Wall
Integration of health education and welfare services in primary care systems is a key strategy to solve the multiple determinants of chronic diseases, such as Human Immunodeficiency Virus Infection and Acquired Immune Deficiency Syndrome (HIV/AIDS). However, there is a scarcity of conceptual models from which to build integration strategies. We provide a model based on cross-sectional data from 168 Community Health Agents, 62 nurses, and 32 physicians in two municipalities in Brazil's Unified Health System (UHS)...
March 14, 2017: International Journal of Environmental Research and Public Health
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