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https://www.readbyqxmd.com/read/29668141/-prevalence-and-risk-factors-associated-to-tuberculosis-and-non-tuberculous-mycobacterial-infections-in-hiv-positive-patients-in-bogot%C3%A3
#1
Magda Beltrán-León, Francy Pérez-Llanos, Liliana Sánchez, Carlos Parra-López, Myriam Navarrete, Ricardo Sánchez, Carlos Awad, Ana María Granada, Edgardo Quintero, Óscar Briceño, Óscar Cruz, Martha Isabel Murcia
INTRODUCTION: Tuberculosis is one of the most widely distributed infectious diseases worldwide. It is the most common cause of mortality among AIDS patients. In Colombia, 12,918 tuberculosis cases were notified, and 926 deaths were reported in 2015. OBJECTIVE: To determine the prevalence and risk factors associated to mycobacterial infections in HIVpositive patients in two public hospitals from Bogotá. MATERIALS AND METHODS: A prospective and descriptive study was carried out by an active search for tuberculosis cases and non-tuberculous mycobacterial infections in HIV-positive patients...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667336/optimal-breastfeeding-durations-for-hiv-exposed-infants-the-impact-of-maternal-art-use-infant-mortality-and-replacement-feeding-risk
#2
Divya Mallampati, Rachel L MacLean, Roger Shapiro, Francois Dabis, Barbara Engelsmann, Kenneth A Freedberg, Valeriane Leroy, Shahin Lockman, Rochelle Walensky, Nigel Rollins, Andrea Ciaranello
INTRODUCTION: In 2010, the WHO recommended women living with HIV breastfeed for 12 months while taking antiretroviral therapy (ART) to balance breastfeeding benefits against HIV transmission risks. To inform the 2016 WHO guidelines, we updated prior research on the impact of breastfeeding duration on HIV-free infant survival (HFS) by incorporating maternal ART duration, infant/child mortality and mother-to-child transmission data. METHODS: Using the Cost-Effectiveness of Preventing AIDS Complications (CEPAC)-Infant model, we simulated the impact of breastfeeding duration on 24-month HFS among HIV-exposed, uninfected infants...
April 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29667004/the-development-of-hiv-vaccines-targeting-gp41-membrane-proximal-external-region-mper-challenges-and-prospects
#3
REVIEW
Huan Liu, Xiaojie Su, Lulu Si, Lu Lu, Shibo Jiang
A human immunodeficiency virus type-1 (HIV-1) vaccine which is able to effectively prevent infection would be the most powerful method of extinguishing pandemic of the acquired immunodeficiency syndrome (AIDS). Yet, achieving such vaccine remains great challenges. The membrane-proximal external region (MPER) is a highly conserved region of the envelope glycoprotein (Env) gp41 subunit near the viral envelope surface, and it plays a key role in membrane fusion. It is also the target of some reported broadly neutralizing antibodies (bNAbs)...
April 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29666292/human-immunodeficiency-virus-tat-protein-aids-v-region-somatic-hypermutation-in-human-b-cells
#4
Xiaohua Wang, Zhi Duan, Guojun Yu, Manxia Fan, Matthew D Scharff
Long-term survivors of human immunodeficiency virus (HIV) infection have been shown to have a greatly increased incidence of B cell lymphomas. This increased lymphomagenesis suggests some link between HIV infection and the destabilization of the host B cell genome, a phenomenon also suggested by the extraordinary high frequency of mutation, insertion, and deletion in the broadly neutralizing HIV antibodies. Since HIV does not infect B cells, the molecular mechanisms of this genomic instability remain to be fully defined...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29664204/characterization-and-epitope-mapping-of-a-panel-of-monoclonal-antibodies-against-hiv-1-matrix-protein
#5
Zhiqing Zhang, Feng Zhang, Shimeng Bai, Jiaming Qiao, Honglin Shen, Fang Huang, Shuangquan Gao, Shaowei Li, Ying Gu, Ningshao Xia
The HIV-1 Gag precursor protein (p55) is the main structural protein comprising the matrix (MA/p17), capsid (CA/p24), and nucleocapsid (NC/p7) proteins, and is uniquely responsible for virion assembly within the virus life cycle. The MA protein plays a critical role in plasma membrane targeting and envelope glycoprotein (Env) uptake during virion assembly. Yet, when viral infection occurs, the MA protein may also be involved in virion uncoating, dissociating from the plasma membrane, and participating in the nuclear importation process...
April 17, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29663926/polyethylenimine-mediated-ccr5-gene-knockout-using-transcription-activator-like-effector-nucleases
#6
Lian Jin, Yan Deng, Nongyue He, Lijun Wang, Mengling Weng
CCR5 acts as one of the key coreceptors for human immunodeficiency virus infection, which leads to acquired immune deficiency syndrome. CCR5 gene knockout comes up as an alternative method for treatment of the disease. Transcription activator-like effector nuclease is a powerful gene editing tool characterized by the ease of design, high rates of cleavage activity, and the accessibility of all ranges of transcription activator-like effector nucleases. In this study, transcription activator-like effector nuclease plasmids specifically targeting to knock out CCR5 gene were designed, constructed and then transfected to Hela and HEK293T cell lines with the assistance of the well-established gene delivery carrier polyethylenimine...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663523/malignant-lymphoma-in-the-hiv-positive-patient
#7
REVIEW
Anne Meister, Marcus Hentrich, Christoph Wyen, Kai Hübel
The introduction of combination antiretroviral therapy (cART) drastically improved performance status, immune function and life expectancy of HIV-infected individuals. In addition, incidence of opportunistic infections and of AIDS-defining malignancies declined. Nevertheless, aggressive non-Hodgkin's lymphoma still remains the leading cause of AIDS-related deaths. The availability of cART, however, significantly improved the therapeutic options for HIV-positive patients with lymphomas. Diffuse large B-cell lymphoma, Burkitt's lymphoma, or Hodgkin lymphoma have increasingly become curable diseases...
April 16, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29661260/implementing-routine-blood-borne-virus-testing-for-hcv-hbv-and-hiv-at-a-london-emergency-department-uncovering-the-iceberg
#8
S Parry, N Bundle, S Ullah, G R Foster, K Ahmad, C Y W Tong, S Balasegaram, C Orkin
UK guidelines recommend routine HIV testing in high prevalence emergency departments (ED) and targeted testing for HBV and HCV. The 'Going Viral' campaign implemented opt-out blood-borne virus (BBV) testing in adults in a high prevalence ED, to assess seroprevalence, uptake, linkage to care (LTC) rates and staff time taken to achieve LTC. Diagnosis status (new/known/unknown), current engagement in care, and severity of disease was established. LTC was defined as patient informed plus ⩾1 clinic visit. A total of 6211/24 981 ED attendees were tested (uptake 25%); 257 (4...
April 17, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29660296/influence-of-aids-antiretroviral-therapy-on-the-growth-pattern
#9
REVIEW
Ana Paula Brigatto Simões Golucci, Fernando Augusto Lima Marson, Mariana Freitas Fedato Valente, Maira Migliari Branco, Camila Carbone Prado, Roberto José Negrão Nogueira
OBJECTIVES: Human immunodeficiency virus infection can result in the early impairment of anthropometric indicators in children and adolescents. However, combined antiretroviral therapy has improved, in addition to the immune response and viral infection, the weight and height development in infected individuals. Therefore, the objective was to evaluate the effect of combined antiretroviral on the growth development of human immunodeficiency virus infected children and adolescents. SOURCE OF DATA: A systematic review was performed...
April 13, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29660143/disseminated-kaposi-sarcoma-with-epithelioid-morphology-in-an-hiv-aids-patient-a-previously-unreported-variant
#10
Pukhraz Basra, Juan Paramo, John Alexis
Kaposi sarcoma is an oligoclonal HHV8-driven vascular proliferation that was first described in 1872 as an "idiopathic multiple pigmented sarcoma of the skin" by a Viennese dermatologist Dr. Moriz Kaposi (1).
April 16, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29659751/a-randomized-placebo-controlled-trial-of-the-quadrivalent-hpv-vaccine-in-hiv-infected-adults-age-27-years-or-older-aids-clinical-trials-group-protocol-a5298
#11
Timothy J Wilkin, Huichao Chen, Michelle S Cespedes, Jorge T Leon-Cruz, Catherine Godfrey, Elizabeth Y Chiao, Barbara Bastow, Jennifer Webster-Cyriaque, Qinghua Feng, Joan Dragavon, Robert W Coombs, Rachel M Presti, Alfred Saah, Ross D Cranston
Background: Adults living with HIV are at increased risk for anal and oropharyngeal cancer caused by human papillomavirus (HPV). The efficacy of HPV vaccines in this population is unknown. Methods: Phase 3, double-blind, randomized controlled trial. We assigned HIV-infected adults age 27 or older to the quadrivalent HPV (Types 6, 11, 16, 18) vaccine or placebo (1:1) stratified by sex and presence of anal high-grade squamous intraepithelial lesions on biopsy (bHSIL)...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29656849/association-of-highly-active-antiretroviral-treatment-with-incident-tuberculosis-in-people-living-with-hiv-aids
#12
Yung-Feng Yen, I-An Jen, Pei-Hung Chuang, Marcelo Chen, Yu-Ching Lan, Chun-Yuan Lee, Yi-Ming Arthur Chen
PURPOSE: To determine the short-term and long-term effects of highly active antiretroviral therapy (HAART) on incident tuberculosis (TB) in people living with HIV/AIDS (PLWHA). METHODS: From 2000 to 2012, we identified adult PLWHA from Taiwan Centers for Disease Control HIV Surveillance System. All PLWHA were followed up until December 31, 2012, and observed for TB occurrence. Time-dependent Cox proportional hazards models were used to determine the short-term and long-term effects of HAART on incident TB...
March 28, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29656416/women-infected-with-hiv-and-the-impact-of-associated-sexually-transmitted-infections
#13
REVIEW
Somaia Reda, Fernanda Aguiar Gonçalves, Melissa Mello Mazepa, Newton Sérgio de Carvalho
OBJECTIVE: To review the relationship between concomitant sexually transmitted infections in women infected with HIV. METHODS: PubMed and Scopus were searched for articles published in English and Portuguese between January 1, 1994, and December 31, 2015, using relevant keywords, including AIDS, HIV, female genital diseases, and sexually transmitted infections. Articles that associated sexually transmitted infections with HIV-infected women were selected for inclusion...
April 14, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29655904/3d-printed-controlled-release-tritherapeutic-tablet-matrix-for-advanced-anti-hiv-1-drug-delivery
#14
Margaret Siyawamwaya, Lisa C du Toit, Pradeep Kumar, Yahya E Choonara, Pierre P P D Kondiah, Viness Pillay
PURPOSE: A 3D-Bioplotter® was employed to 3D print (3DP) a humic acid-polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet comprising of the anti-HIV-1 drugs, efavirenz (EFV), tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC). METHODS: Chemical interactions, surface morphology and mechanical strength of the FDC were ascertained. In vitro drug release studies were conducted in biorelevant media followed by in vivo study in the large white pigs, in comparison with a market formulation, Atripla® ...
April 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29652613/knowledge-and-concern-about-stis-hiv-and-sociodemographic-variables-associated-with-getting-tested-for-hiv-among-the-general-population-in-spain
#15
Inmaculada Teva, Ludgleydson Fernandes de Araújo, María de la Paz Bermúdez
HIV testing is important in terms of prevention and treatment. However, HIV testing rates in the Spanish general population remains low. Therefore, HIV testing promotion constitutes a key issue. A high level of knowledge about HIV/AIDS is associated with having been tested for HIV. The general aim of this study was to determine the prevalence of people who had ever been tested for HIV in Spain. The sample consisted of 1,106 participants from the general population - 60.0% females and 40.0% males - aged between 17 and 55 years old...
April 13, 2018: Journal of Psychology
https://www.readbyqxmd.com/read/29651922/prior-exposure-to-intimate-partner-violence-associated-with-less-hiv-testing-among-young-women
#16
Yukiko Washio, Elizabeth Novack Wright, Annet Davis-Vogel, Jesse Chittams, Claire Anagnostopulos, Linda M Kilby, Anne M Teitelman
Low-income minority women are disproportionately represented among those living with HIV in the United States. They are also at risk for the SAVA (substance abuse, violence, and HIV/AIDS) syndemic issues. Women who have recently given birth are at high risk for substance use and intimate partner violence (IPV), and HIV testing is not routinely administered during the postpartum visit. We explored the relationship between substance use, IPV, and HIV testing among low-income young adult women attending Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), a federally supported nutrition program...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29650451/hiv-incidence-in-western-kenya-during-scale-up-of-antiretroviral-therapy-and-voluntary-medical-male-circumcision-a-population-based-cohort-analysis
#17
Martien W Borgdorff, Daniel Kwaro, David Obor, George Otieno, Viviane Kamire, Frederick Odongo, Patrick Owuor, Jacques Muthusi, Lisa A Mills, Rachael Joseph, Mary E Schmitz, Peter W Young, Emily Zielinski-Gutierrez, Kevin M De Cock
BACKGROUND: In Kenya, coverage of antiretroviral therapy (ART) among people with HIV infection has increased from 7% in 2006, to 57% in 2016; and, in western Kenya, coverage of voluntary medical male circumcision (VMMC) increased from 45% in 2008, to 72% in 2014. We investigated trends in HIV prevalence and incidence in a high burden area in western Kenya in 2011-16. METHODS: In 2011, 2012, and 2016, population-based surveys were done via a health and demographic surveillance system and home-based counselling and testing in Gem, Siaya County, Kenya, including 28 688, 17 021, and 16 772 individuals aged 15-64 years...
April 9, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29650217/effect-of-logo-therapy-acceptance-commitment-therapy-family-psychoeducation-on-self-stigma-and-depression-on-housewives-living-with-hiv-aids
#18
Titi Sri Suyanti, Budi Anna Keliat, Novy Helena Catharina Daulima
OBJECTIVE: Self-stigma in people living with HIV/AIDS is a survival mechanism to protect themselves from external stigma. Stigma and discrimination in people living with HIV/AIDS can lead to inequality in social life. This inequality can cause inferiority complex, preoccupation, and denial of diagnosis, which correlates with the onset of depression. This study aims to determine the effect of logotherapy, commitment acceptance therapy, and family psychoeducation on self-stigma and depression on housewives living with HIV/AIDS...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29649107/impaired-hematologic-status-in-relation-to-clinical-outcomes-among-hiv-infected-adults-from-uganda-a-prospective-cohort-study
#19
Amara E Ezeamama, David Guwatudde, Alla Sikorskii, Edmond K Kabagambe, Raybun Spelts, Grace Vahey, Jenifer I Fenton, Wafaie W Fawzi
Impaired hematologic status (IHS) was investigated as a determinant of immune function defined as cluster of differentiation 4 (CD4) T-helper cell count, quality of life (QOL) weight and hospitalization/mortality over 18-months among 398 adult persons living with HIV/AIDS (PLWHA) on anti-retroviral therapy. IHS was defined as having anemia at baseline (Hemoglobin: <12 g/dL for women and <13 g/dL for men), time-updated anemia or having low (<30 μg/L) or high (>200 μg/L for men and >150 μg/L for women) ferritin levels at baseline...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29648942/a-phenomenology-of-informal-caregiving-for-hiv-aids-in-india-exploring-women-s-search-for-authoritative-knowledge-self-efficacy-and-resilience
#20
Shrivridhi Shukla, Judith L M McCoyd
Women provide informal caregiving across the world and are often expected to provide care even when ailing themselves. We explore the lived experience of 33 impoverished married Indian women living with HIV, caring for their husbands and/or children living with HIV. Drawing on concepts of authoritative knowledge (AK), self-efficacy and resilience, we found a trajectory that reveals barriers to accessing care, yet we also found that women developed strengths and resiliency. Women gather information, develop 'environ-info,' and deliberatively weigh AK from health workers, family/friends' advice, and their own experiences...
April 12, 2018: Health Care for Women International
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