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https://www.readbyqxmd.com/read/29241393/multidimensional-approach-for-the-proper-management-of-a-complex-chronic-patient-with-chronic-obstructive-pulmonary-disease
#1
Paola Rogliani, Vito Brusasco, Leonardo Fabbri, Andrea Ungar, Elisa Muscianisi, Ilaria Barisone, Alberto Corsini, Giuseppe De Angelis
Chronic obstructive pulmonary disease (COPD) is frequently associated with comorbidities occurring either independently or as consequences of COPD. Areas covered: This review examines the interactions between the pathophysiology of COPD and the most frequent comorbidities, and highlights the need for multidimensional clinical strategies to manage COPD patients with comorbidities. Expert commentary: Most COPD patients need to be approached in a complex and multifactorial scenario. The diagnosis of COPD is necessarily based on the presence of chronic respiratory symptoms and poorly reversible airflow obstruction, but exacerbations and comorbidities need to be considered in the evaluation of disease severity and prognosis in individual patients...
December 15, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29238186/severe-copd-cases-from-korea-poland-and-usa-have-substantial-differences-in-respiratory-symptoms-and-other-respiratory-illnesses
#2
Woo Jin Kim, Jae-Joon Yim, Deog Kyeom Kim, Myung Goo Lee, Anne L Fuhlbrigge, Pawel Sliwinski, Iwona Hawrylkiewicz, Emily S Wan, Michael H Cho, Edwin K Silverman
Purpose: Chronic obstructive pulmonary disease (COPD), characterized by irreversible airflow obstruction, is a major cause of morbidity and mortality worldwide. However, geographic differences in the clinical characteristics of severe COPD patients have not been widely studied. Methods: We recruited a total of 828 severe COPD cases from three continents. Subjects in Poland were enrolled by the Institute of Tuberculosis and Lung Diseases in Warsaw; subjects in Korea participated at several university hospitals in Korea; and subjects in USA were enrolled at two clinics affiliated with academic medical centers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29238182/adherence-to-a-copd-treatment-guideline-among-patients-in-hong-kong
#3
Ka Pang Chan, Fanny Ws Ko, Hok Sum Chan, Mo Lin Wong, Thomas Yw Mok, Kah Lin Choo, David Sc Hui
Background: This study aimed to assess the adherence rate of pharmacological treatment to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline published in 2011 and the prevalence of comorbidities among patients with COPD in Hong Kong (HK). Methods: Patients were recruited from five tertiary respiratory centers and followed up for 12 months. Data on baseline physiological, spirometric parameters, use of COPD medications and coexisting comorbidities were collected...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29232989/impact-of-cataract-on-health-related-quality-of-life-in-a-longitudinal-japanese-chronic-obstructive-pulmonary-cohort
#4
Hidehiro Irie, Shotaro Chubachi, Minako Sato, Mamoru Sasaki, Naofumi Kameyama, Takashi Inoue, Yoshitaka Oyamada, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku
Cigarette smoking increases the risk of developing both cataract and chronic obstructive pulmonary disease (COPD). The prevalence of cataract and the clinical characteristics of COPD patients with cataract were retrospectively investigated in a 2-year observational COPD cohort. We analyzed 395 patients with complete data on ophthalmologic evaluation (319 subjects with COPD and 76 subjects at risk of COPD). There was no difference in the prevalence of cataract between COPD patients and those at risk (47.0% vs...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29232680/is-outpatient-control-of-long-term-non-invasive-ventilation-feasible-in-chronic-obstructive-pulmonary-disease-patients
#5
Sarah Bettina Schwarz, Jens Callegari, Christine Hamm, Wolfram Windisch, Friederike Sophie Magnet
BACKGROUND: Long-term non-invasive ventilation (NIV) is an established and increasingly used treatment option for patients with chronic hypercapnic chronic obstructive pulmonary disease (COPD). Following inpatient NIV establishment, inpatient control visits regularly occur thereafter. However, it remains unclear whether such control visits can also be performed in an outpatient setting, which, in turn, would reduce costs, patient burden and the complications related to hospitalization...
December 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29231234/feasibility-acceptability-and-effectiveness-of-integrated-care-for-copd-patients-a-mixed-methods-evaluation-of-a-pilot-community-based-programme
#6
Tania Carron, Pierre-Olivier Bridevaux, Karin Lörvall, Rachel Parmentier, Jean-Bernard Moix, Vincent Beytrison, Raymond Pernet, Constance Rey, Pierre-Yves Roberfroid, Prashant N Chhajed, Thomas Dieterle, Ladina Joos Zellweger, Malcolm Kohler, Sabrina Maier, David Miedinger, Robert Thurnheer, Pascal Urwyler, Jean-Marie Tschopp, Emilie Zuercher, Jörg Daniel Leuppi, Bernard Burnand, Isabelle Peytremann-Bridevaux
QUESTION UNDER STUDY: The aim of this study was to assess the feasibility, acceptability and effectiveness of a pilot COPD integrated care programme implemented in Valais, Switzerland. METHODS: The programme was adapted from the self-management programme Living Well with COPD, and included the following elements: self-management patient-education group sessions, telephone and medical follow-ups, multidisciplinary teams, training of healthcare professionals, and evidence-based COPD care...
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29231073/pelargonium-sidoides-preparation-eps-7630-in-copd-health-related-quality-of-life-and-other-patient-reported-outcomes-in-adults-receiving-add-on-therapy
#7
Heinrich Matthys, Petra Funk
OBJECTIVE: Patient-reported outcomes (PRO) such as health-related quality of life (HRQL) belong to the most important criteria for the evaluation of medical therapies in clinical trials or practice-based benefit assessments. We therefore revisited results of an earlier published clinical trial investigating the effects of the herbal drug preparation from the roots of Pelargonium sidoides EPs 7630, administered as add-on therapy in patients suffering from chronic obstructive pulmonary disease (COPD), with respect to HRQL and other PRO...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29229110/effects-of-two-types-of-equal-intensity-inspiratory-muscle-training-in-stable-patients-with-chronic-obstructive-pulmonary-disease-a-randomised-controlled-trial
#8
Weiliang Wu, Lili Guan, Xianming Zhang, Xiaoying Li, Yuqiong Yang, Bingpeng Guo, Yonger Ou, Lin Lin, Luqian Zhou, Rongchang Chen
PURPOSE: We conducted a randomised controlled trial to assess the effects of daily breathing pattern changes to stable patients with COPD excluding the confounding factors of inspiratory muscle mobilization, by ensuring the load intensities of two inspiratory training devices were equal. PATIENTS AND METHODS: Sixty patients with COPD were randomised to three groups: resistive-IMT group (T-IMT, 21 patients), threshold-IMT (R-IMT, 19 patients), and a control group (20 patients)...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29229095/primary-immune-deficiency-diseases-as-unrecognized-causes-of-chronic-respiratory-disease
#9
REVIEW
Melvin Berger, Bob Geng, D William Cameron, Ladonna M Murphy, Edward S Schulman
BACKGROUND: More than half of all primary immune deficiency diseases (PIDD) affect antibody production and are well known as causes of recurrent sinusitis and lung infections. Chronic and recurrent infections of the upper and/or lower airways can contribute to inflammatory and obstructive processes in the lower airways which are initially reversible and considered "asthma", but can eventually cause irreversible remodeling and chronic obstructive pulmonary disease (COPD). Conversely, several lines of evidence suggest that many patients who present with a diagnosis of asthma have an increased incidence of infection, suggesting underlying host-defense defects...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29228916/physical-and-psychosomatic-health-outcomes-in-people-bereaved-by-suicide-compared-to-people-bereaved-by-other-modes-of-death-a-systematic-review
#10
Ailbhe Spillane, Celine Larkin, Paul Corcoran, Karen Matvienko-Sikar, Fiona Riordan, Ella Arensman
BACKGROUND: Little research has been conducted into the physical health implications of suicide bereavement compared to other causes of death. There is some evidence that suicide bereaved parents have higher morbidity, particularly in terms of chronic illness. This systematic review aims to examine the physical and psychosomatic morbidities of people bereaved by a family member's suicide and compare them with family members bereaved by other modes of death. METHODS: MEDLINE, EMBASE, CINAHL, and PsycINFO were searched from 1985 to February 2016...
December 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29228288/outcome-measures-used-in-pulmonary-rehabilitation-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-a-systematic-review
#11
Ana L Oliveira, Alda S Marques
Background: Conflicting results about the effects of community-based pulmonary rehabilitation in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) exist, possibly because the variety of outcome measures used and the lack of appropriate measurement properties hinder the development of pulmonary rehabilitation guidelines. Purpose: The purpose of this study was to identify and review the measurement properties of patient-reported outcome measures (PROMs) and clinical outcome measures of AECOPD that are used in pulmonary rehabilitation and that can be easily applied in a community setting...
December 6, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29225775/fibromax-based-nonalcoholic-fatty-liver-disease-in-chronic-obstructive-pulmonary-disease-patients-with-obstructive-sleep-apnea-methodological-considerations
#12
Denis Monneret
The relationship between nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) has been well demonstrated, but remains to be evidenced in chronic obstructive pulmonary disease (COPD). Recently, Viglino et al. (Eur Respir J, 2017) attempted to determine the prevalence of liver fibrosis, steatosis and nonalcoholic steatohepatitis (NASH) in COPD patients, some of whom had OSA, basing the NAFLD diagnostic on three circulating biomarker-based liver scores: the FibroTest, SteatoTest and NashTest, from the Fibromax® panel...
2017: F1000Research
https://www.readbyqxmd.com/read/29224299/-correlation-analysis-of-serum-secreted-frizzled-related-protein-5-levels-with-airway-inflammation-and-insulin-resistance-in-chronic-obstructive-pulmonary-disease-patients
#13
G Y Li, S J Yin, Y Liu, H Li, S Song, Z B Kong, C Zuo, H Liu, Z Zhu
Objective: To investigate the relationship between serum secreted frizzled-related protein 5(sfrp5) levels, insulin resistance, and airway inflammation in patients with chronic obstructive pulmonary disease(COPD). Method: A total of 178 COPD patients visiting our respiratory outpatient clinic from February 2015 to January 2017 were enrolled, and 99 healthy control subjects from the same time period were selected. Serum sfrp5 levels were compared between the 2 groups. Serum sfrp5 and inflammatory cytokines in induced sputum were observed in the 4 subgroups: insulin resistant COPD group [homeostasis model assessment of insulin resistance (HOMA-IR)≥2...
December 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29223853/role-of-mir-195-in-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease
#14
Wenchao Gu, Yaping Yuan, Hua Yang, Hao Wu, Linxuan Wang, Zhijun Tang, Qiang Li
Chronic obstructive pulmonary disease (COPD) is regarded as a persistent respiratory symptom, mainly caused by cigarette smoking. Recent data have suggested that some miRNAs are involved in the pathogenesis of COPD. Here, we found that miR-195 was significantly upregulated in the lung tissues of patients with COPD compared to in never smokers. miR-195 expression was also upregulated in cigarette smoke (CS)-exposed mice. Lentivirus-mediated knockdown of miR-195 alleviated CS-induced lung pathological changes and reduced inflammatory cell infiltration as well as production of interleukin-6 and tumor necrosis factor-α in bronchoalveolar lavage fluid...
December 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29223018/targeting-oxidant-dependent-mechanisms-for-the-treatment-of-respiratory-diseases-and-their-comorbidities
#15
REVIEW
Neil C Thomson
Oxidative stress is implicated in the pathogenesis of respiratory diseases, such as COPD and its comorbidities, asthma, idiopathic pulmonary fibrosis and radiation pneumonitis. Antioxidants drugs, such as small molecule thiols, nuclear erythroid-2 related factor 2 activators and catalytic enzyme mimetics have been developed to target oxidant-dependent mechanisms. The therapeutic effects of antioxidants have been generally disappointing. A small number of antioxidants are approved for clinical use, such as the small molecule thiol N-acetyl-l-cysteine for chronic obstructive pulmonary disease, and in the United States, the superoxide dismutase mimetic AEOL 10150 for severe radiation pneumonitis...
December 6, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29221643/respiratory-and-cardiovascular-responses-to-walking-down-a-traffic-polluted-road-compared-with-walking-in-a-traffic-free-area-in-participants-aged-60-years-and-older-with-chronic-lung-or-heart-disease-and-age-matched-healthy-controls-a-randomised-crossover
#16
Rudy Sinharay, Jicheng Gong, Benjamin Barratt, Pamela Ohman-Strickland, Sabine Ernst, Frank Kelly, Junfeng Jim Zhang, Peter Collins, Paul Cullinan, Kian Fan Chung
BACKGROUND: Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from ischaemic heart disease and exacerbations of COPD. We aimed to assess the effects on respiratory and cardiovascular responses of walking down a busy street with high levels of pollution compared with walking in a traffic-free area with lower pollution levels in older adults...
December 5, 2017: Lancet
https://www.readbyqxmd.com/read/29217721/insights-from-australians-with-respiratory-disease-living-in-the-community-with-experience-of-self-managing-through-an-emergency-department-near-miss-for-breathlessness-a-strengths-based-qualitative-study
#17
Tim Luckett, Jane Phillips, Miriam Johnson, Maja Garcia, Priyanka Bhattarai, Virginia Carrieri-Kohlman, Anne Hutchinson, Rebecca T Disler, David Currow, Meera Agar, Serra Ivynian, Richard Chye, Phillip J Newton, Patricia M Davidson
OBJECTIVES: Breathlessness 'crises' in people with chronic respiratory conditions are a common precipitant for emergency department (ED) presentations, many of which might be avoided through improved self-management and support. This study sought insights from people with experience of ED 'near misses' where they considered going to the ED but successfully self-managed instead. DESIGN AND METHODS: A qualitative approach was used with a phenomenological orientation...
December 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#18
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29216193/community-prevalence-of-chronic-respiratory-symptoms-in-rural-malawi-implications-for-policy
#19
Hastings T Banda, Rachael Thomson, Kevin Mortimer, George A F Bello, Grace B Mbera, Rasmus Malmborg, Brian Faragher, S Bertel Squire
BACKGROUND: No community prevalence studies have been done on chronic respiratory symptoms of cough, wheezing and shortness of breath in adult rural populations in Malawi. Case detection rates of tuberculosis (TB) and chronic airways disease are low in resource-poor primary health care facilities. OBJECTIVE: To understand the prevalence of chronic respiratory symptoms and recorded diagnoses of TB in rural Malawian adults in order to improve case detection and management of these diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29212488/identification-of-the-lipid-biomarkers-from-plasma-in-idiopathic-pulmonary-fibrosis-by-lipidomics
#20
Feng Yan, Zhensong Wen, Rui Wang, Wenling Luo, Yufeng Du, Wenjun Wang, Xianyang Chen
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an irreversible interstitial pulmonary disease featured by high mortality, chronic and progressive course, and poor prognosis with unclear etiology. Currently, more studies have been focusing on identifying biomarkers to predict the progression of IPF, such as genes, proteins, and lipids. Lipids comprise diverse classes of molecules and play a critical role in cellular energy storage, structure, and signaling. The role of lipids in respiratory diseases, including cystic fibrosis, asthma and chronic obstructive pulmonary disease (COPD) has been investigated intensely in the recent years...
December 6, 2017: BMC Pulmonary Medicine
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