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https://www.readbyqxmd.com/read/29665262/effects-of-inspiratory-muscle-training-in-copd-patients-a-systematic-review-and-meta-analysis
#1
REVIEW
Marc Beaumont, Patrice Forget, Francis Couturaud, Gregory Reychler
OBJECTIVES: In chronic obstructive pulmonary disease (COPD), quality of life and exercise capacity are altered in relationship to dyspnea. Benefits of inspiratory muscle training (IMT) on quality of life, dyspnea and exercise capacity were demonstrated, but when it is associated to pulmonary rehabilitation (PR), its efficacy on dyspnea is not demonstrated. The aim of this systematic review with meta analysis was to verify the effect of IMT using threshold devices in COPD patients on dyspnea, quality of life, exercise capacity and inspiratory muscles strength, and the added effect on dyspnea of IMT associated with PR (versus PR alone)...
April 17, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29658804/comparison-of-effects-of-endurance-and-strength-training-programs-in-patients-with-copd
#2
Michael J Berry, Katherine L Sheilds, Norman E Adair
Comparisons between endurance and strength training in chronic obstructive pulmonary disease (COPD) patients have produced equivocal findings when examining physical function and health-related quality of life (HRQL). One reason for these differences may be due to individual patient responses to the different training modalities. PURPOSE: To compare changes in physical function and HRQL in a group of COPD patients completing both an endurance and a strength training program. METHODS: Eleven mildly diseased patients completed a three month endurance training program and, approximately 5 years later, completed a three month strength training program...
April 16, 2018: COPD
https://www.readbyqxmd.com/read/29658361/myd88-as-a-therapeutic-target-for-inflammatory-lung-diseases
#3
Franco Di Padova, Valerie F J Quesniaux, Bernhard Ryffel
Introduction Myeloid differentiation primary response protein 88 (MyD88) is a critical adaptor protein involved in Toll-like and IL-1 receptor family signaling controlling innate immune responses and inflammation. Genetic deletion of MyD88 function results in profound suppression of inflammation and reduced resistance of the host to pathogens indicating non-redundant roles of MyD88. The TIR domain is critical for MyD88 dimerization and signaling for TLR and IL-1R family receptor. Areas covered Emerging evidence suggests that chemical disruption of the TIR domain attenuates cell activation and inhibits in vivo MyD88-dependent inflammation...
April 16, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29656668/effect-of-smoking-on-gene-expression-profile-overall-mechanism-impact-on-respiratory-system-function-and-reference-to-electronic-cigarettes
#4
Paulina Natalia Kopa, Rafał Pawliczak
Cigarette smoke has an crucial impact on transcriptome alteration by its effect on chromatin remodeling and DNA methylation status. The first mechanism is associated with the histone acetylation/deacetylation balance damage as a result of increased activity of NFĸB and lipid peroxidation products, which lead to an increased activity of HATs and DNMTs and reduced HDACs. The second mechanism is connected with direct damaging of DNA by smoke components, activation of downstream repair mechanism and recruitment of DNMTs into the breakage site, "nicotine effect" and carbon monoxide activity on gene transcription and DNA methylation reduction...
April 16, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29656319/nlrp3-inflammasome-involves-in-the-acute-exacerbation-of-patients-with-chronic-obstructive-pulmonary-disease
#5
Huaying Wang, Chun'er Lv, Shi Wang, Huajuan Ying, Yuesong Weng, Wanjun Yu
The NLR pyrin domain-containing protein 3 (NLRP3) inflammasome, a multi-protein complex, produces the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, which may contribute to the development of airway inflammation in chronic obstructive pulmonary disease (COPD). The aim of this study was to explore the correlation between circulating and local airway NLRP3 inflammasome activation with acute exacerbation of COPD (AECOPD). mRNA levels of NLRP3, Caspase (Casp)-1, apoptosis-associated speck-like protein containing CARD (ASC), IL-18, and IL-1β in peripheral blood mononuclear cells (PBMCs) and bronchial tissues were determined by real-time PCR in 32 smokers, 65 patients with AECOPD, 50 COPD patients in recovery stage, and 30 COPD patients in stable stage...
April 14, 2018: Inflammation
https://www.readbyqxmd.com/read/29653129/delivering-drugs-to-the-lungs-the-history-of-repurposing-in-the-treatment-of-respiratory-diseases
#6
Stephen P Newman
The repurposing of drug delivery by the pulmonary route has been applied to treatment and prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been most successful for the delivery of inhaled bronchodilators and corticosteroids in patients with asthma and chronic obstructive pulmonary disease (COPD). Repurposing utilizes the advantages that the pulmonary route offers in terms of more targeted delivery to the site of action, the use of smaller doses, and a lower incidence of side-effects...
April 10, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29652760/influence-of-disease-severity-and-exercise-limitation-on-exercise-training-intensity-and-load-and-health-benefits-from-pulmonary-rehabilitation-in-patients-with-copd-an-exploratory-study
#7
Virginia C Huynh, Desi P Fuhr, Bradley W Byers, Anne-Marie Selzler, Linn E Moore, Michael K Stickland
PURPOSE: Some patients with chronic obstructive pulmonary disease (COPD) fail to achieve health benefits with pulmonary rehabilitation (PR). Exercise intensity and load represent stimulus for adaptation but it is unclear whether inappropriate exercise intensity and/or load are affected by severity of COPD, which may affect health benefits. The purpose was to determine whether COPD severity and/or the severity of pulmonary limitation to exercise (PLE) impacted exercising intensity or load and whether resultant intensity/load affected health outcomes derived from PR...
April 11, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29652272/comparison-of-immediate-extubation-versus-ultrafast-tracking-strategy-in-the-management-of-off-pump-coronary-artery-bypass-surgery
#8
Amarja Sachin Nagre, Nagesh P Jambures
Introduction: Ultrafast tracking of anesthesia (UFTA) is practiced routinely, whereas immediate on-table extubation after off-pump coronary artery bypass (OPCAB) grafting surgery has many concerns. The purpose of our study was to evaluate the safety and feasibility of immediate extubation (IE) versus UFTA. Methods: Sixty patients were enrolled who underwent OPCAB surgery. The two groups IE and UFTA had thirty patients each. Inclusion criteria were patients for OPCAB surgery including left main stenosis...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29650248/prevalence-and-risk-factors-of-chronic-obstructive-pulmonary-disease-in-china-the-china-pulmonary-health-cph-study-a-national-cross-sectional-study
#9
Chen Wang, Jianying Xu, Lan Yang, Yongjian Xu, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Wanzhen Yao, Tieying Sun, Guangliang Shan, Ting Yang, Yingxiang Lin, Sinan Wu, Jianguo Zhu, Ruiying Wang, Zhihong Shi, Jianping Zhao, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Liren Ding, Ting Yang, Yahong Chen, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Chung-Shiuan Chen, Zuomin Wang, Hong Zhang, Xiaoning Bu, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Bin Cao, Huaping Dai, Lirong Liang, Jiang He
BACKGROUND: Although exposure to cigarette smoking and air pollution is common, the current prevalence of chronic obstructive pulmonary disease (COPD) is unknown in the Chinese adult population. We conducted the China Pulmonary Health (CPH) study to assess the prevalence and risk factors of COPD in China. METHODS: The CPH study is a cross-sectional study in a nationally representative sample of adults aged 20 years or older from ten provinces, autonomous regions, and municipalities in mainland China...
April 9, 2018: Lancet
https://www.readbyqxmd.com/read/29649849/-copd-importance-of-lung-function-testing-for-diagnosis-and-treatment
#10
Wolfram Windisch, Carl Peter Criée
Pulmonary function testing is essential for diagnosis and treatment-guidance of chronic obstructive pulmonary disease (COPD). Airway obstruction as assessed by spirometry should follow the reference-values provided by the Global Lung Initiative (GLI) of the European Respiratory Society (ERS). In addition, lung function testing should also include the assessment of lung hyperinflation and pulmonary emphysema by full-body plethysmography and determination of diffusion capacity. This is important since both, lung hyperinflation and pulmonary emphysema, can present without existing airway obstruction...
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29643669/which-is-better-a-standalone-ventilation-or-perfusion-scan-or-combined-imaging-to-predict-postoperative-fev-1-in-one-seconds-in-patients-posted-for-lung-surgeries-with-borderline-pulmonary-reserve
#11
Padma Subramanyam, P Shanmuga Sundaram
Introduction: Forced expiratory volume in one second (FEV1 ) is an independent predictor for respiratory morbidity. Reports are varied and controversial substantiating the use of either lung perfusion (Q) or ventilation (V) scintigraphy as a single stage investigation to predict postoperative (ppo) FEV1 in patients scheduled for lung resection surgeries. It is said that there is no additional benefit by performing both V/Q scan. As per one of the recommendations, no further respiratory function tests are required for a lobectomy if the postbronchodilator FEV1 is >1...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29629404/marijuana-use-associations-with-pulmonary-symptoms-and-function-in-tobacco-smokers-enrolled-in-the-subpopulations-and-intermediate-outcome-measures-in-copd-study-spiromics
#12
Madeline A Morris, Sean R Jacobson, Gregory L Kinney, Donald P Tashkin, Prescott G Woodruff, Eric A Hoffman, Richard E Kanner, Christopher B Cooper, M Brad Drummond, R Graham Barr, Elizabeth C Oelsner, Barry J Make, MeiLan K Han, Nadia N Hansel, Wanda K O'Neal, Russell P Bowler
Background: Marijuana is often smoked via a filterless cigarette and contains similar chemical makeup as smoked tobacco. There are few publications describing usage patterns and respiratory risks in older adults or in those with chronic obstructive pulmonary disease (COPD). Methods: A cross-sectional analysis of current and former tobacco smokers from the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) study assessed associations between marijuana use and pulmonary outcomes. Marijuana use was defined as never, former (use over 30 days ago), or current (use within 30 days)...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29629402/the-short-term-impact-of-symptom-defined-copd-exacerbation-recovery-on-health-status-and-lung-function
#13
Lindsey T Murray, Nancy K Leidy
Background: This study examined the short-term effects of symptom-defined exacerbation recovery on health status and pulmonary function in moderate to severe chronic obstructive pulmonary disease (COPD) patients. Methods: Secondary analyses of pooled data from two 12-week Phase II international, randomized controlled trials using the EXA cerbations of C hronic Pulmonary Disease T ool (EXACT) to identify symptom-defined exacerbations were conducted. Recovery was categorized as recovered, unrecovered (persistent worsening), or censored...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29629037/association-of-time-to-first-morning-cigarette-and-chronic-obstructive-pulmonary-disease-measured-by-spirometry-in-current-smokers
#14
Geonhyeok Kim, Hongji Song, Kyunghee Park, Hyemi Noh, Eunyoung Lee, Hyoeun Lee, Hayoon Kim, Yujin Paek
Background: Time to first cigarette after waking is an indicator of nicotine dependence. We aimed to identify the association between time to first cigarette and spirometry-proven obstructive respiratory impairment, especially chronic obstructive pulmonary disease, in current smokers. Methods: We included 392 subjects who visited the comprehensive medical examination center of Hallym University Sacred Heart Hospital between July 2014 and September 2015. Subjects with lung disease or anemia were excluded...
March 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29628971/establishment-of-a-chronic-obstructive-pulmonary-disease-mouse-model-based-on-the-elapsed-time-after-lps-intranasal-instillation
#15
Soon-Young Lee, Jin-Ho Cho, Seung Sik Cho, Chun-Sik Bae, Gye-Yeop Kim, Dae-Hun Park
Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing, mucous hypersecretion, and finally breathlessness. Recently, anti-COPD drug development has increased, and many animal screening systems have been studied. Tobacco smoke animal models are the best known animal screening system, but have several preparation requirements, such as a tobacco smoke generator and a separate facility to prevent smoke release...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628761/respiratory-parameters-predict-poor-outcome-in-copd-patients-category-gold-2017-b
#16
Kristian Brat, Marek Plutinsky, Karel Hejduk, Michal Svoboda, Patrice Popelkova, Jaromir Zatloukal, Eva Volakova, Miroslava Fecaninova, Lucie Heribanova, Vladimir Koblizek
Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29628437/chronic-respiratory-failure-in-patients-with-chronic-obstructive-pulmonary-disease-under-home-noninvasive-ventilation-real-life-study
#17
V Durão, M Grafino, P Pamplona
BACKGROUND: Home noninvasive ventilation (NIV) has been increasingly used in stable chronic obstructive pulmonary disease (COPD) with chronic hypercapnic respiratory failure (CHRF). However its effectiveness remains debatable. AIM: To describe a follow-up of COPD patients under home NIV. METHODS: Retrospective descriptive study based on a prospective 3-year database that included COPD patients under home NIV between August 2011 and July 2014...
April 5, 2018: Pulmonology
https://www.readbyqxmd.com/read/29626985/asthma-chronic-obstructive-pulmonary-disease-overlap-aco-an-emerging-entity-in-allergic-respiratory-diseases
#18
EDITORIAL
Jun Tamaoki, Kenji Izuhara
No abstract text is available yet for this article.
April 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29621056/associations-between-ambient-nitrogen-dioxide-and-daily-cause-specific-mortality-evidence-from-272-chinese-cities
#19
Renjie Chen, Peng Yin, Xia Meng, Lijun Wang, Cong Liu, Yue Niu, Zhijing Lin, Yunning Liu, Jiangmei Liu, Jinlei Qi, Jinling You, Haidong Kan, Maigeng Zhou
BACKGROUND: There has been a long history of debate regarding whether ambient nitrogen dioxide (NO2) directly affects human health. METHODS: We conducted a nationwide time-series analysis in 272 major Chinese cities (2013-2015) to evaluate the associations between short-term exposure to NO2 and cause-specific mortality. We used the overdispersed generalized linear model together with the Bayesian hierarchical model to estimate the associations between NO2 and mortality at the national and regional levels...
April 4, 2018: Epidemiology
https://www.readbyqxmd.com/read/29617859/human-lung-epithelial-cells-support-human-metapneumovirus-persistence-by-overcoming-apoptosis
#20
Stefania Marsico, Francesca Caccuri, Pietro Mazzuca, Paola Apostoli, Sara Roversi, Giovanni Lorenzin, Alberto Zani, Simona Fiorentini, Cinzia Giagulli, Arnaldo Caruso
Human metapneumovirus (hMPV) has been identified as a major cause of lower respiratory tract infection in children. Epidemiological and molecular evidence has highlighted an association between severe childhood respiratory viral infection and chronic lung diseases, such as asthma and chronic obstructive pulmonary disease. Currently, animal models have demonstrated the ability of hMPV to persist in vivo suggesting a role of the virus in asthma development in children. However, mechanisms involved in hMPV persistence in the respiratory tract are not yet understood...
March 1, 2018: Pathogens and Disease
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