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Oral sub mucous fibrosis

Anji Anura, Debanjan Das, Mousumi Pal, Ranjan Rashmi Paul, Soumen Das, Jyotirmoy Chatterjee
Oral sub-mucous fibrosis (OSF), a potentially malignant disorder, exhibits extensive remodeling of extra-cellular matrix in the form of sub-epithelial fibrosis which is a possible sequel of assaults from different oral habit related irritants. It has been assumed that micro/nanobio-mechanical imbalance experienced in the oral mucosa due to fibrosis may be deterministic for malignant potential (7-13%) of this pathosis. Present study explores changes in mechanobiological attributes of sub-epithelial connective tissue of OSF and the normal counterpart...
January 2017: Journal of the Mechanical Behavior of Biomedical Materials
Krithiga Shridhar, Aastha Aggarwal, Gagandeep Kaur Walia, Smriti Gulati, A V Geetha, D Prabhakaran, Preet K Dhillon, Preetha Rajaraman
BACKGROUND: Oral cancers are preceded by oral potentially malignant disorders (OPMD). Understanding genetic susceptibility for OPMD risk could provide an opportunity for risk assessment of oral cancer through early disease course. We conducted a review of single nucleotide polymorphism (SNP) studies for OPMD risk. METHODS: We identified all relevant studies examining associations of SNPs with OPMD (leukoplakia, erythroplakia and oral sub-mucous fibrosis) conducted world-wide between January, 2000 and February, 2016 using a combined keyword search on PubMed...
October 2016: Oral Oncology
Hira Tariq, Owais Ahmed Khan, Muhammad Tariq Aftab
Various Risk factors initiate Submucous fibrosis which may be augmented by NSAIDs. A number of animal studies on their mechanism indirectly support it especially regarding alterations in prostaglandin synthesis. This study has been designed to find association of these drugs with Oral Submucous fibrosis in the presence of risk factors. Newly diagnosed patients of Oral Sub mucous fibrosis were recruited for this study who attended Dental Department of Karachi Medical and Dental College from July 1 till Dec 31, 2013...
March 2016: Pakistan Journal of Pharmaceutical Sciences
Nishant Raj Chourasia, Rajiv M Borle, Ankita Vastani
AIM: To evaluate the incidence of oral squamous cell carcinoma concomitant with oral sub mucous fibrosis in central India and to correlate precipitating factors associated with oral submucous fibrosis and oral squamous cell carcinoma. This paper also aims to study the incidence of oral squamous cell carcinoma arising secondary to untreated oral submucous fibrosis. MATERIALS AND METHODS: Two hundred and twenty five cases of oral squamous cell carcinoma and one hundred and nineteen cases of oral submucous fibrosis of various regions in oral cavity were included in the study...
December 2015: Journal of Maxillofacial and Oral Surgery
Abhayjeet Singh, Rama Brahmam Lanke, Rakhith Shetty, Syed Akifuddin, Manish Sahu, Navneet Singh, Gagandeep Kaur, Garish Goyal
BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic progressive debilitating disease affecting the oral, oropharyngeal and sometimes the oesophageal mucosa resulting in inability to eat due to burning, ulcers and stiffness. AIM: The study was undertaken, to evaluate the correlation of clinical staging, histological grading and nutritional status using body mass index (BMI) with gutkha (habit) index in OSMF patients. MATERIALS AND METHODS: The study group comprised of 50 patients clinically diagnosed and histopathologically confirmed cases of OSMF...
October 2015: Journal of Clinical and Diagnostic Research: JCDR
Sathyanarayanan Ramanujam, Suresh Venkatachalam, Monica Subramaniyan, Deepika Subramaniyan
Various surgical procedures are available for treating oral submucous fibrosis, but all of them have their inherent drawbacks. The superiorly based platysma myocutaneous flap is a common reconstruction option for intraoral defects followed after excision of fibrous bands in oral submucous fibrosis. The superiorly based flap has an excellent blood supply, but less efficient venous drainage when compared with posteriorly based flap. We present our results of using a superiorly based flap in the treatment of oral submucous fibrosis...
August 2015: Journal of Pharmacy & Bioallied Sciences
Jasdeep Kaur, Constantinus Politis, Reinhilde Jacobs
BACKGROUND: Apoptosis is a genetically programmed form of cell death which is indispensable for development and homeostasis of multi-cellular organism. OBJECTIVES: The aim of this study was to find out the salivary apoptotic cells in oral precancerous and cancerous patients and furthermore to observe the potential diagnostic value of salivary apoptotic cells in detection of oral pre-cancer and cancer. MATERIAL AND METHODS: Unsimulated saliva was collected from a group of 103 subjects diagnosed with oral (pre-)cancer and a control group of 30 healthy age- and gender-matched individuals...
July 2015: Journal of Clinical and Experimental Dentistry
Dushyant Mandlik, Karan Gupta, Daxesh Patel, Purvi Patel, Rajendra Toprani, Kaustubh Patel
INTRODUCTION: Restricted mouth opening due to premalignant lesions like oral sub-mucous fibrosis, malignancies of oral cavity and postoperative status is very common in Indian patients. It is very difficult to evaluate, document and biopsy the lesions due to inability to access, vast area and diversity of premalignant lesions and subject variations. 90° Hopkin's slender out-patient examination telescope was found useful tool in this. AIM: The aim of the study was to evaluate the use of magnified view and reach of a slender telescope to document and examine the oral cavity for any premalignant and malignant lesions, especially for patients with restricted mouth opening and to study its impact on management...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
S Nithya, T Radhika, Nadeem Jeddy
Loricrin is a terminally differentiating structural protein comprising more than 70% of the cornified envelope. It contributes to the protective barrier function of the stratum corneum. In vivo, loricrin is expressed inall mammalian stratified epithelia with the highest levels of expression in humid tissues such as newborn epidermis, the epithelia of oral and anal mucosa, esophagus, foreskin, vagina and the epidermal parts of sweat ducts. Loricrin is not expressed in non keratinizing epithelia and its expression at these sites actually represents a defensive or protective mechanismof the body...
January 2015: Journal of Oral and Maxillofacial Pathology: JOMFP
Anji Anura, Sailesh Conjeti, Raunak Kumar Das, Mousumi Pal, Ranjan Rashmi Paul, Swarnendu Bag, Ajoy Kumar Ray, Jyotirmoy Chatterjee
BACKGROUND: Evaluation of molecular pathology markers using a computer-aided quantitative assessment framework would help to assess the altered states of cellular proliferation, hypoxia, and neoangiogenesis in oral submucous fibrosis and could improve diagnostic interpretation in gauging its malignant potentiality. METHODS: Immunohistochemical (IHC) expression of c-Myc, hypoxia-inducible factor-1-alpha (HIF-1α), vascular endothelial growth factor (VEGF), VEGFRII, and CD105 were evaluated in 58 biopsies of oral submucous fibrosis using computer-aided quantification...
May 2016: Head & Neck
Maheswari H, Eswaran M A, Srividhya S, Malavika R, Prabhu R, Geetha K R
PURPOSE OF THE STUDY: The present study was conducted to estimate the serum levels of Circulating Immune Complexes in patients with Oral Leukoplakia ,Oral sub mucous fibrosis and normal subjects and correlate these values with the clinical grades of the diseases. MATERIALS AND METHODS: The study consisted of 25 Oral Leukoplakia patients, 25 Oral sub mucous fibrosis patients and 25 Normal subjects. RESULTS: The mean serum levels of CIC showed a gradual increase from normal subjects to Oral Leukoplakia patients and showed a high values in Oral sub mucous fibrosis patients...
January 2014: Journal of Clinical and Diagnostic Research: JCDR
Bhavana Sujana Mulk, Prasannasrinivas Deshpande, Nagalakshmi Velpula, Vani Chappidi, Raja Lakshmi Chintamaneni, Stuti Goyal
BACKGROUND: Oral submucous fibrosis is a habit associated insidious precancerous condition of the oral cavity commonly found in Asian countries. Many treatment modalities have been attempted in treating the condition apart from steroids which have been the main stay. Hence the present study was designed to assess the efficacy of spirulina and pentoxyfilline and also to compare them in oral submucous fibrosis. MATERIAL AND METHODS: Fourty Patients with clinico-histological diagnosis of oral sub mucous fibrosis were selected and divided into two groups with 20 in each group by simple randomization method...
December 2013: Journal of Clinical and Diagnostic Research: JCDR
Swarnendu Bag, Sailesh Conjeti, Raunak Kumar Das, Mousami Pal, Anji Anura, Ranjan Rashmi Paul, Ajoy Kumar Ray, Sanghamitra Sengupta, Jyotirmoy Chatterjee
BACKGROUND: Oral submucous fibrosis (OSF) is a pre-cancerous condition with features of chronic, inflammatory and progressive sub-epithelial fibrotic disorder of the buccal mucosa. In this study, malignant potentiality of OSF has been assessed by quantification of immunohistochemical expression of epithelial prime regulator-p63 molecule in correlation to its malignant (oral squamous cell carcinoma [OSCC] and normal counterpart [normal oral mucosa [NOM]). Attributes of spatial extent and distribution of p63(+) expression in the epithelium have been investigated...
2013: Journal of Pathology Informatics
Mulay Gauri, Dugal Ramandeep
Patients with microstomia who need to wear removable dental prosthesis often face difficulty of being unable to insert or remove the prosthesis because of restricted opening of the oral cavity. Prosthetic rehabilitation of patients with microstomia presents difficulties in all the clinical steps. In such patients, it is difficult to make impressions and fabricate dentures using conventional method. This clinical report describes prosthodontic management of a completely edentulous patient with microstomia developed due to oral sub mucous fibrosis...
September 2013: Journal of Indian Prosthodontic Society
M R Ramesh Babu, C Ramesh, K Thirumurugan, G Arun Prasad
Deep vein thrombosis (DVT) is caused by obstruction of blood flow of deep veins in upper and lower limb. One of the precipitating factors for DVT is surgery under general anesthesia exceeding 30 min. However, there are very few reports of DVT associated with surgery of oral and maxillofacial region. In this paper we report two cases of DVT involving left ilio-femoropopliteal deep vein in one patient treated for fractured left angle of mandible and left peroneal vein in the other patient treated for oral sub mucous fibrosis...
April 2013: Contemporary Clinical Dentistry
Raunak Kumar Das, Anji Anura, Mousumi Pal, Swarnendu Bag, Subhadipa Majumdar, Ananya Barui, Chandan Chakraborty, Ajoy Kumar Ray, Sanghamitra Sengupta, Ranjan Rashmi Paul, Jyotirmoy Chatterjee
Evaluating molecular attributes in association with its epithelial and sub-epithelial changes of oral sub-mucous fibrosis is meaningful in exploring the plausibility of an epithelio-mesenchymal transition (EMT) and malignant potentiality of this pathosis. In this study histopathological and histochemical attributes for basement membrane and connective tissue in biopsies of oral sub-mucous fibrosis (n = 55) and normal oral mucosa (n = 16) were assessed and expressions of p63, E-cadherin, β-catenin, N-cadherin and TWIST were analyzed immunohistochemically...
December 2013: Experimental and Molecular Pathology
Muhammad Faisal, Madiha Rana, Anjum Shaheen, Riaz Warraich, Horst Kokemueller, André Michael Eckardt, Nils-Claudius Gellrich, Majeed Rana
Oral sub mucous fibrosis is a rare chronic, progressive, pre malignant collagen disorder of oral mucosa in people of Asian descent characterized by trismus, blanching and stiffness of mucosa, burning sensation in mouth and hypomobility of soft palate and tongue with loss of gustatory sensation. Betel nut chewing is the most common etiological agent. Surgery remains the main stay in severe cases and aims at release of fibrotic bands and resurfacing the raw areas with different options. Reconstruction can be done by using nasolabial flap or radial free forearm flap...
2013: Orphanet Journal of Rare Diseases
K Saravanan, M Kodanda Ram, R Ganesh
Oral sub mucous fibrosis is an insidious chronic disease affecting any part of the oral cavity. Worldwide estimates of oral sub mucous fibrosis indicate that 2.5 million people are affected, with most cases concentrated in the Indian subcontinent, especially eastern and southern India. Oral sub mucous fibrosis has a propensity for malignant transformation. The association of betel quid chewing, oral sub mucous fibrosis, and oral squamous cell carcinoma is quite profound, especially in Taiwan and the Indian subcontinent where up to 80% of oral squamous cell carcinoma is associated with the habit...
April 2013: Journal of Cancer Research and Therapeutics
Sunali Khanna, A C Udas, G Kiran Kumar, S Suvarna, F R Karjodkar
Oral cancer is a major cause of cancer morbidity and mortality worldwide and is prevalent in most areas where tobacco related practices are observed. Essential elements play a role in many biochemical reactions as a micro-source and there is growing evidence that their concentrations are altered on the onset and progress of malignant disease. In this study the levels of copper (Cu), zinc (Zn), selenium (Se) and molybdenum (Mo) in serum of patients with oral sub mucous fibrosis (OSMF) (n = 30) and oral squamous cell carcinoma (OSCC) (n = 30); were determined and the alterations of these critical parameters were analyzed in comparison with controls (n = 30) to identify predictors amongst these parameters for disease occurrence and progression...
October 2013: Journal of Trace Elements in Medicine and Biology
K Subhash Chandra Bose, Prerna Vyas Gokhale, Sunil Dwivedi, Manika Singh
BACKGROUND: Cancer is one of the most common causes of mortality and morbidity today, with more than 10 million new cases and more than 6 million deaths each year worldwide. Globally Oral Cancer is the sixth most common cause of cancer related death. India accounts for 86% of the world's oral cancer cases. Often it proceeds by pre cancerous conditions and lesions. In search for biological markers with diagnostic value, we investigated serum glycoconjugates like protein bound hexoses, fucose and sialic acid in these diseases...
January 2013: Journal of Natural Science, Biology, and Medicine
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