keyword
MENU ▼
Read by QxMD icon Read
search

Cognitive immaturity

keyword
https://www.readbyqxmd.com/read/28462362/early-life-stress-leads-to-developmental-and-sex-selective-effects-on-performance-in-a-novel-object-placement-task
#1
Kevin G Bath, Arielle Schilit Nitenson, Ezra Lichtman, Chelsea Lopez, Whitney Chen, Meghan Gallo, Haley Goodwill, Gabriela Manzano-Nieves
Disruptions in early life care, including neglect, extreme poverty, and trauma, influence neural development and increase the risk for and severity of pathology. Significant sex disparities have been identified for affective pathology, with females having an increased risk of developing anxiety and depressive disorder. However, the effects of early life stress (ELS) on cognitive development have not been as well characterized, especially in reference to sex specific impacts of ELS on cognitive abilities over development...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28440309/glypican-2-levels-in-cerebrospinal-fluid-predict-the-status-of-adult-hippocampal-neurogenesis
#2
S Lugert, T Kremer, R Jagasia, A Herrmann, S Aigner, C Giachino, I Mendez-David, A M Gardier, J P Carralot, H Meistermann, A Augustin, M D Saxe, J Lamerz, G Duran-Pacheco, A Ducret, V Taylor, D J David, C Czech
Adult hippocampal neurogenesis is a remarkable form of brain plasticity through which new neurons are generated throughout life. Despite its important roles in cognition and emotion and its modulation in various preclinical disease models, the functional importance of adult hippocampal neurogenesis in human health has not been revealed because of a lack of tools for monitoring adult neurogenesis in vivo. Therefore, we performed an unbiased proteomics screen to identify novel proteins expressed during neuronal differentiation using a human neural stem cell model, and we identified the proteoglycan Glypican-2 (Gpc2) as a putative secreted marker of immature neurons...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28434870/maternal-socioeconomic-disadvantage-is-associated-with-transcriptional-indications-of-greater-immune-activation-and-slower-tissue-maturation-in-placental-biopsies-and-newborn-cord-blood
#3
Gregory E Miller, Ann E Borders, Amy H Crockett, Kharah M Ross, Sameen Qadir, Lauren Keenan-Devlin, Adam K Leigh, Paula Ham, Jeffrey Ma, Jesusa M G Arevalo, Linda M Ernst, Steve W Cole
Children from economically disadvantaged families experience worse cognitive, psychiatric, and medical outcomes compared to more affluent youth. Preclinical models suggest some of the adverse influence of disadvantage could be transmitted during gestation via maternal immune activation, but this hypothesis has not been tested in humans. It also remains unclear whether prenatal interventions can mitigate such effects. To fill these gaps, we conducted two studies. Study 1 characterized the socioeconomic conditions of 79 women during pregnancy...
April 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28433501/disrupted-in-schizophrenia-1-regulates-the-processing-of-reelin-in-the-perinatal-cortex
#4
Nicholas J Bradshaw, Svenja V Trossbach, Sabrina Köber, Susanne Walter, Ingrid Prikulis, Sascha Weggen, Carsten Korth
Disrupted in Schizophrenia 1 (DISC1) is a prominent gene in mental illness research, encoding a scaffold protein known to be of importance in the developing cerebral cortex. Reelin is a critical extracellular protein for development and lamination of the prenatal cortex and which has also been independently implicated in mental illness. Regulation of reelin activity occurs through processing by the metalloproteinases ADAMTS-4 and ADAMTS-5. Through cross-breeding of heterozygous transgenic DISC1 mice with heterozygous reeler mice, which have reduced reelin, pups heterozygous for both phenotypes were generated...
April 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28428263/different-requirements-of-functional-telomeres-in-neural-stem-cells-and-terminally-differentiated-neurons
#5
Anastasia Lobanova, Robert She, Simon Pieraut, Charlie Clapp, Anton Maximov, Eros Lazzerini Denchi
Telomeres have been studied extensively in peripheral tissues, but their relevance in the nervous system remains poorly understood. Here, we examine the roles of telomeres at distinct stages of murine brain development by using lineage-specific genetic ablation of TRF2, an essential component of the shelterin complex that protects chromosome ends from the DNA damage response machinery. We found that functional telomeres are required for embryonic and adult neurogenesis, but their uncapping has surprisingly no detectable consequences on terminally differentiated neurons...
April 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28426648/pregnancy-swimming-causes-short-and-long-term-neuroprotection-against-hypoxia-ischemia-in-very-immature-rats
#6
Eduardo Farias Sanches, Luz Elena Duran Carabali, Andrea Tosta, Fabrício Nicola, Felipe Schmitz, André Rodrigues, Cassiana Siebert, Angela Wyse, Carlos Alexandre Netto
BACKGROUND: Hypoxia-ischemia (HI) is a major cause of neurological damage in preterm. Pregnancy swimming alters the pup's brain development. We tested the effects of swimming during pregnancy in the very immature rat brain. METHODS: Female Wistar rats (n=12) were assigned to sedentary (SE, n=6) or swimming groups (SW, n=6). From the gestational day 0 (DG0) to GD21 they performed 20 min/daily swimming sessions. HI on postnatal day 3 rat cause sensorimotor and cognitive impairments...
April 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28392763/activation-in-context-differential-conclusions-drawn-from-cross-sectional-and-longitudinal-analyses-of-adolescents-cognitive-control-related-neural-activity
#7
Ethan M McCormick, Yang Qu, Eva H Telzer
Although immature cognitive control, subserved by late-developing prefrontal regions, has been proposed to underlie increased risk taking during adolescence, it remains unclear what patterns of PFC activation represent mature brain states: more or less activation? One challenge to drawing cogent conclusions from extant work stems from its reliance on single-time point neuroimaging and cross-sectional comparisons, which are ill-suited for assessing the complex changes that characterize adolescence. This necessitates longitudinal fMRI work to track within-subject changes in PFC function and links to risk-taking behavior, which can serve as an external marker for maturation of neural systems involved in cognitive control...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28375680/electroacupuncture-improves-cognitive-function-and-hippocampal-neurogenesis-after-brain-irradiation
#8
Xing-Wen Fan, Huan-Huan Liu, Hong-Bing Wang, Fu Chen, Yu Yang, Yan Chen, Shi-Kuo Guan, Kai-Liang Wu
Cognitive impairments after brain irradiation seriously affect quality of life for patients, and there is currently no effective treatment. In this study using an irradiated rat model, the role of electroacupuncture was investigated for treatment of radiation-induced brain injury. Animals received 10 Gy exposure to the entire brain, and electroacupuncture was administered 3 days before irradiation as well as up to 2 weeks postirradiation. Behavioral tests were performed one month postirradiation, and rats were then sacrificed for histology or molecular studies...
April 4, 2017: Radiation Research
https://www.readbyqxmd.com/read/28366775/noonan-syndrome-associated-shp2-mutation-differentially-modulates-the-expression-of-postsynaptic-receptors-according-to-developmental-maturation
#9
Jun-Young Oh, Sangmyung Rhee, Alcino J Silva, Yong-Seok Lee, Hyong Kyu Kim
Glutamate is the major excitatory neurotransmitter in the central nervous system, and related signaling involves both AMPA and NMDA subtype receptors. The expression of glutamate receptors is dynamically regulated during development. Recent studies showed that the dysregulation of glutamate receptor expression and function is associated with neurodevelopmental disorders including intellectual disability. Previously, a Noonan syndrome (NS)-associated SHP2 mutation (SHP2(D61G)) was shown to increase the synaptic delivery of AMPA receptor, subsequently impairing synaptic plasticity and learning in adult mice...
March 31, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28330787/acute-impact-of-caffeinated-alcoholic-beverages-on-cognition-a-systematic-review
#10
REVIEW
Laurence Lalanne, Pierre-Eric Lutz, François Paille
INTRODUCTION: Energy drinks are popular beverages that are supposed to counteract sleepiness, increase energy, maintain alertness and reduce symptoms of hangover. Cognitive enhancing seems to be related to many compounds such as caffeine, taurine and vitamins. Currently, users mostly combine psychostimulant effects of energy drinks to counteract sedative effects of alcohol. However, recent literature suggests that this combination conducts to feel less intoxicated but still impaired. The goal of the present article is to review cognitive impact and subjective awareness in case of caffeinated alcoholic beverage (CAB) intoxication...
March 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28302742/neurodevelopmental-abnormalities-and-congenital-heart-disease-insights-into-altered-brain-maturation
#11
REVIEW
Paul D Morton, Nobuyuki Ishibashi, Richard A Jonas
In the past 2 decades, it has become evident that individuals born with congenital heart disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk factors contributing to neurodevelopmental abnormalities associated with CHD have been identified; however, the underlying causes remain largely unknown, and efforts to address this issue have only recently begun. There has been a dramatic shift in focus from newly acquired brain injuries associated with corrective and palliative heart surgery to antenatal and preoperative factors governing altered brain maturation in CHD...
March 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28270754/interaction-effect-of-social-isolation-and-high-dose-corticosteroid-on-neurogenesis-and-emotional-behavior
#12
Jackie N-M Chan, Jada C-D Lee, Sylvia S P Lee, Katy K Y Hui, Alan H L Chan, Timothy K-H Fung, Dalinda I Sánchez-Vidaña, Benson W-M Lau, Shirley P-C Ngai
Hypercortisolemia is one of the clinical features found in depressed patients. This clinical feature has been mimicked in animal studies via application of exogenous corticosterone (CORT). Previous studies suggested that CORT can induce behavioral disturbance in anxious-depressive like behavior, which is associated with suppressed neurogenesis. Hippocampal neurogenesis plays an important role in adult cognitive and behavioral regulation. Its suppression may thus lead to neuropsychiatric disorders. Similar to the effects of CORT on the animals' depression-like behaviors and neurogenesis, social deprivation has been regarded as one factor that predicts poor prognosis in depression...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28256073/aging-impairs-dendrite-morphogenesis-of-newborn-neurons-and-is-rescued-by-7-8-dihydroxyflavone
#13
Xiaoting Wang, Jennifer Lynn Romine, Xiang Gao, Jinhui Chen
All aging individuals will develop some degree of decline in cognitive capacity as time progresses. The molecular and cellular mechanisms leading to age-related cognitive decline are still not fully understood. Through our previous research, we discovered that active neural progenitor cells selectively become more quiescent in response to aging, thus leading to the decline of neurogenesis in the aged hippocampus. Here, we further find that aging impaired dendrite development of newborn neurons. Currently, no effective approach is available to increase neurogenesis or promote dendrite development of newborn neurons in the aging brain...
April 2017: Aging Cell
https://www.readbyqxmd.com/read/28219751/evidence-for-a-role-of-corticopetal-noradrenergic-systems-in-the-development-of-executive-function
#14
David J Mokler, Christine E Miller, Jill A McGaughy
Adolescence is a period during which many aspects of executive function are maturing. Much of the literature has focused on discrepancies between sub-cortical and cortical development that is hypothesized to lead to over-processing of reinforcement related stimuli unchecked by fully matured response inhibition. Specifically, maturation of sub-cortical dopaminergic systems that terminate in the nucleus accumbens has been suggested to occur prior to the full maturation of corticopetal dopaminergic systems. However, converging evidence supports the hypothesis that many aspects of cognitive control are critically linked to cortical noradrenergic systems, that the effectiveness of drugs used to treat disorders of executive function, e...
February 17, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28193596/vegf-regulates-hippocampal-neurogenesis-and-reverses-cognitive-deficits-in-immature-rats-after-status-epilepticus-through-the-vegf-r2-signaling-pathway
#15
Wei Han, Xiaojie Song, Rong He, Tianyi Li, Li Cheng, Lingling Xie, Hengsheng Chen, Li Jiang
Epilepsy is the most common chronic disease in children, who exhibit a higher risk for status epilepticus (SE) than adults. Hippocampal neurogenesis is altered by epilepsy, particularly in the immature brain, which may influence cognitive development. Vascular endothelial growth factor (VEGF) represents an attractive target to modulate brain function at the neurovascular interface and is a double-edged sword in seizures. We used the lithium-pilocarpine-induced epilepsy model in immature Sprague-Dawley rats to study the effects of VEGF on hippocampal neurogenesis in the acute phase and on long-term cognitive behaviors in immature rats following status epilepticus (SE)...
February 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28138095/long-lasting-memory-deficits-in-mice-withdrawn-from-cocaine-are-concomitant-with-neuroadaptations-in-hippocampal-basal-activity-gabaergic-interneurons-and-adult-neurogenesis
#16
David Ladrón de Guevara-Miranda, Carmelo Millón, Cristina Rosell-Valle, Mercedes Pérez-Fernández, Michele Missiroli, Antonia Serrano, Francisco J Pavón, Fernando Rodríguez de Fonseca, Magdalena Martínez-Losa, Manuel Álvarez-Dolado, Luis J Santín, Estela Castilla-Ortega
Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional pathology that impedes recovery. We studied whether a persistent cognitive/emotional dysregulation in mice withdrawn from cocaine holds a neurobiological correlate within the hippocampus, a limbic region with a key role in anxiety and memory but that has been scarcely investigated in cocaine addiction research. Mice were submitted to a chronic cocaine (20 mg/kg/day for 12 days) or vehicle treatment followed by 44 drug-free days...
March 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28131877/carbon-monoxide-incompletely-prevents-isoflurane-induced-defects-in-murine-neurodevelopment
#17
Li Wang, Aili Wang, William W Supplee, Kayla Koffler, Ying Cheng, Zenaide M N Quezado, Richard J Levy
BACKGROUND: Commonly used anesthetics have been shown to disrupt neurodevelopment in preclinical models. It has been proposed that such anesthesia-induced neurotoxicity is mediated by apoptotic neurodegeneration in the immature brain. Low dose carbon monoxide (CO) exerts cytoprotective properties and we have previously demonstrated that CO inhibits isoflurane-induced apoptosis in the developing murine brain. Here we utilized anti-apoptotic concentrations of CO to delineate the role of apoptotic neurodegeneration in anesthesia-induced neurotoxicity by assessing the effect of CO on isoflurane-induced defects in neurodevelopment...
January 26, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28113197/neurogenesis-enhances-response-specificity-to-spatial-pattern-stimulation-in-hippocampal-cultures
#18
Yukimi Tanaka, Takuya Isomura, Kenta Shimba, Kiyoshi Kotani, Yasuhiko Jimbo
OBJECTIVE: Adult neurogenesis in the hippocampus facilitates cognitive functions such as pattern separation in mammals. However, it remains unclear how newborn neurons mediate changes in neural networks to enhance pattern separation ability. Here, we developed an in vitro model of adult neurogenesis using rat hippocampal cultures in order to investigate whether newborn neurons can be directly incorporated into neural networks related to pattern separation to produce functional improvements...
December 14, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28076846/effect-of-trp53-gene-deficiency-on-brain-injury-after-neonatal-hypoxia-ischemia
#19
Ana A Baburamani, Kristina S Sobotka, Regina Vontell, Carina Mallard, Veena G Supramaniam, Claire Thornton, Henrik Hagberg
Hypoxia-ischemia (HI) can result in permanent life-long injuries such as motor and cognitive deficits. In response to cellular stressors such as hypoxia, tumor suppressor protein p53 is activated, potently initiating apoptosis and promoting Bax-dependent mitochondrial outer membrane permeabilization. The aim of this study was to investigate the effect of Trp53 genetic inhibition on injury development in the immature brain following HI. HI (50 min or 60 min) was induced at postnatal day 9 (PND9) in Trp53 heterozygote (het) and wild type (WT) mice...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28056424/neonatal-anesthetic-neurotoxicity-insight-into-the-molecular-mechanisms-of-long-term-neurocognitive-deficits
#20
REVIEW
Deshui Yu, Linji Li, Weiguo Yuan
Mounting animal studies have demonstrated that almost all the clinically used general anesthetics could induce widespread neuroapoptosis in the immature brain. Alarmingly, some published findings have reported long-term neurocognitive deficits in response to early anesthesia exposure which deeply stresses the potential seriousness of developmental anesthetic neurotoxicity. However, the connection between anesthesia induced neuroapoptosis and subsequent neurocognitive deficits remains controversial. It should be noted that developmental anesthesia related neurotoxicity is not limited to neuroapoptosis...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
keyword
keyword
61082
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"