Haoshen Shi, Nazanin Mirzaei, Yosef Koronyo, Miyah R Davis, Edward Robinson, Gila M Braun, Ousman Jallow, Altan Rentsendorj, V Krishnan Ramanujan, Justyna Fert-Bober, Andrei A Kramerov, Alexander V Ljubimov, Lon S Schneider, Warren G Tourtellotte, Debra Hawes, Julie A Schneider, Keith L Black, Rakez Kayed, Maj-Linda B Selenica, Daniel C Lee, Dieu-Trang Fuchs, Maya Koronyo-Hamaoui
IMPORTANCE: This study identifies and quantifies diverse pathological tau isoforms in the retina of both early and advanced-stage Alzheimer's disease (AD) and determines their relationship with disease status. OBJECTIVE: A case-control study was conducted to investigate the accumulation of retinal neurofibrillary tangles (NFTs), paired helical filament (PHF)-tau, oligomeric tau (oligo-tau), hyperphosphorylated tau (p-tau), and citrullinated tau (Cit-tau) in relation to the respective brain pathology and cognitive dysfunction in mild cognitively impaired (MCI) and AD dementia patients versus normal cognition (NC) controls...
February 16, 2024: bioRxiv