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https://www.readbyqxmd.com/read/29236379/alcohol-consumption-and-low-risk-drinking-guidelines-among-adults-a-cross-sectional-analysis-from-alberta-s-tomorrow-project
#1
Darren R Brenner, Tiffany R Haig, Abbey E Poirier, Alianu Akawung, Christine M Friedenreich, Paula J Robson
INTRODUCTION: Moderate to heavy alcohol consumption is a risk factor for all-cause mortality and cancer incidence. Although cross-sectional data are available through national surveys, data on alcohol consumption in Alberta from a large prospective cohort were not previously available. The goal of these analyses was to characterize the levels of alcohol consumption among adults from the Alberta's Tomorrow Project in the context of cancer prevention guidelines. Furthermore, we conducted analyses to examine the relationships between alcohol consumption and other high-risk or risk-related behaviours...
December 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29236345/ferrocene-alkynyl-conjugated-molecular-wires-synthesis-characterization-and-conductance-properties
#2
Ye Yuan, Jian-Feng Yan, Da-Qiang Lin, Bing-Wei Mao, Yao-Feng Yuan
A novel series of 1, 2, 3-substituted ferrocene-based wires 1a-2a and 4b-5b have been synthesized using iterative Pd-mediated Sonogashira cross-coupling methodology.The molecular structures of 2a and 3b were determined by single-crystal X-ray analysis.Electrochemical data showed that there was a strong electronic communication among the ferrocenyl moieties in 1b-5b. The UV absorption spectra indicated that replacing 1, 1'-substituted ferrocene unit with 1, 2, 3-substituted ferrocene moiety causes delocalization of electrons in the extended π orbitals...
December 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29236287/characterization-of-a-norovirus-specific-monoclonal-antibody-that-exhibits-wide-spectrum-binding-activities
#3
Lijun Zheng, Wenhui Wang, Jinjin Liu, Xuhui Chen, Sanjing Li, Qiaoli Wang, Yuqi Huo, Chuan Qin, Shuo Shen, Mingchen Wang
Noroviruses (NoVs) are increasingly recognized as the leading cause of acute non-bacterial gastroenteritis worldwide. To screen for NoV-specific monoclonal antibodies (mAbs) with wide spectrum binding activities that could be used for the development of NoV-related detection reagents, we immunized mice with a combination of virus like particles (VLPs) derived from eight different genotypes (two from genogroup I and six from genogroup II), of which two (GI.7 and GII.2) were newly produced VLPs. Indirect enzyme-linked immunosorbent assay (ELISA) confirmed that two mAbs (8D8 and 10B11) bound to all eight major capsid proteins (VP1) with varied binding abilities...
December 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29236253/iclip-of-the-piwi-protein-aubergine-in-drosophila-embryos
#4
Bridlin Barckmann, Jérémy Dufourt, Martine Simonelig
Piwi-interacting RNAs (piRNAs) are a class of small noncoding RNAs bound to specific Argonaute proteins, the PIWI proteins. piRNAs target mRNAs by complementarity to silence them; they play an important role in the repression of transposable elements in the germ line of many species. piRNAs and PIWI proteins are also involved in diverse biological processes through their role in the regulation of cellular mRNAs. In the Drosophila embryo, they contribute to the maternal mRNA decay occurring during the maternal-to-zygotic transition...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29236251/par-clip-for-discovering-target-sites-of-rna-binding-proteins
#5
Aitor Garzia, Pavel Morozov, Marcin Sajek, Cindy Meyer, Thomas Tuschl
RNA-binding proteins (RBPs) establish posttranscriptional gene regulation (PTGR) by coordinating the maturation, editing, transport, stability, and translation of cellular RNAs. A variety of experimental approaches have been developed to characterize the RNAs associated with RBPs in vitro as well as in vivo. Our laboratory developed Photoactivatable-Ribonucleoside-Enhanced Cross-Linking and Immunoprecipitation (PAR-CLIP), which in combination with next-generation sequencing enables the identification of RNA targets of RBPs at a nucleotide-level resolution...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29236217/the-association-between-medical-diagnosis-and-caregiver-burden-a-cross-sectional-study-of-recipients-of-informal-support-and-caregivers-from-the-general-population-study-good-aging-in-sk%C3%A3-ne-sweden
#6
Sölve Elmståhl, Beth Dahlrup, Henrik Ekström, Eva Nordell
BACKGROUND: Different kinds of chronic diseases might imply different dimensions of caregiver burden, not previously described among the caregivers to recipients from the general elder population. AIM: The main objective was to examine differences in burden between the 343 caregivers to persons with different diagnoses. METHODS: A group of elderly recipients of informal care (n = 343) from the general population study 'Good Aging in Skåne' (GÅS) Sweden, were divided into five diagnostic groups: dementia (n = 90), heart and lung diseases (n = 48), stroke (n = 62), fractures (n = 66), depression (n = 40) and the group "other", consisting of different diagnoses (n = 37) according to ICD-10...
December 13, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29236204/the-burden-of-pure-anisometropic-amblyopia-a-cross-sectional-study-on-2800-iranians
#7
Siamak Akbarzadeh, Reihaneh Vahabi, Nooshin Bazzazi, Ghodratollah Roshanaei, Samira Heydarian, Daniel F Fouladi
PURPOSE: To assess the proportion of pure anisometropic amblyopia in a sample Iranian (white) population. METHODS: A total of 2800 consecutive individuals who presented at a referral eye clinic for any reason were examined for the presence of pure anisometropic amblyopia. Anisometropia was reported when a spherical equivalent refraction difference of at least 1.0 D with or without a cylinder refraction difference of at least 1.0 D was present between the two eyes...
December 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29236195/measures-of-subclinical-cardiac-dysfunction-and-increased-filling-pressures-associate-with-pulmonary-arterial-pressure-in-the-general-population-results-from-the-population-based-rotterdam-study
#8
Ryan J Billar, Maarten J G Leening, Daphne Merkus, Guy G O Brusselle, Albert Hofman, Bruno H Ch Stricker, H Ardeschir Ghofrani, Oscar H Franco, Henning Gall, Janine F Felix
Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available...
December 13, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29236114/stereodynamics-of-electron-induced-dissociative-ionization-of-n2-studied-by-e-e-ion-spectroscopy
#9
Noboru Watanabe, So Yamada, Masahiko Takahashi
We report an (e, e+ion) spectroscopy study on electron-induced dissociative ionization of N2. Vector correlation between the scattered electron and N+ ion has been measured for inner-valence ionization of N2 at an incident electron energy of 1.4 keV and scattering angles of 2.2°, 4.2°, and 8.2°. By analyzing the experimental data, partial ion yield spectra have been obtained for transitions to the C 2Σ, F 2Σ, and 2σ ion states, showing that the individual transitions depend on the momentum transferred to the target, K, in different ways...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29236105/a-new-potential-energy-surface-of-the-oh2-system-and-state-to-state-quantum-dynamics-studies-of-the-o-h2-reaction
#10
Wentao Li, Jiuchuang Yuan, Meiling Yuan, Yong Zhang, Minghai Yao, Zhigang Sun
A new global potential energy surface (PES) of the O+ + H2 system was constructed with the permutation invariant polynomial neural network method, using about 63 000 ab initio points, which were calculated by employing the multi-reference configuration interaction method with aug-cc-pVTZ and aug-cc-pVQZ basis sets. For improving the accuracy of the PES, the basis set was extrapolated to the complete basis set limit by the two-point extrapolation method. The root mean square error of fitting was only 5.28 × 10-3 eV...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29236090/novel-hydrogel-advanced-modified-clay-nanocomposites-as-possible-vehicles-for-drug-delivery-and-controlled-release
#11
Raluca Ianchis, Claudia M Ninciuleanu, Ioana C Gifu, Elvira Alexandrescu, Raluca Somoghi, Augusta R Gabor, Silviu Preda, Cristina L Nistor, Sabina Nitu, Cristian Petcu, Madalina Icriverzi, Paula E Florian, Anca M Roseanu
Present study refers to the synthesis of new advanced materials based on poly(methacrylic acid) (PMAA) with previously reported own advanced modified clays by edge covalent bonding. This will create the premises to obtain nanocomposite hydrogels with combined hydrophilic-hydrophobic behavior absolutely necessary for co-delivery of polar/nonpolar substances. For the synthesis, N,N'-methylenebisacrylamide was used as cross-linker and ammonium persulphate as initiator. As a consequence of the inclusion of clay into the polymer matrix and the intercalation of PMAA between the layers as well as the presence of hydrophobic interactions occurred between partners, the final hydrogel nanocomposites possessed greater swelling degrees, slower de-swelling process and enhanced mechanical properties depending on the clay type in comparison with pure hydrogel...
December 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29236069/a-portrait-of-the-sialyl-glycan-receptor-specificity-of-the-h10-influenza-virus-hemagglutinin-a-picture-of-an-avian-virus-on-the-verge-of-becoming-a-pandemic
#12
REVIEW
Elena K Schneider, Jian Li, Tony Velkov
Pandemic influenza is a constant global threat to human health. In particular, the pandemic potential of novel avian influenza viruses such as the H10N7 and H10N8 avian strains, which recently managed to cross the species barrier from birds to humans, are always of great concern as we are unlikely to have any prior immunity. Human and avian isolates of H10 influenza display the ability to rapidly adapt to replication in mammalian hosts. Fortunately, so far there is no evidence of efficient human-to-human transmission of any avian influenza virus...
December 13, 2017: Vaccines
https://www.readbyqxmd.com/read/29235993/raman-micro-spectroscopy-analysis-of-human-lens-epithelial-cells-exposed-to-a-low-dose-range-of-ionizing-radiation
#13
Christian Harry Allen, Achint Kumar, Sami Qutob, Balazs J Nyiri, Vinita Chauhan, Sangeeta Murugkar
Recent findings in populations exposed to ionizing radiation (IR) indicate dose-related lens opacification occurs at much lower doses (< 2Gy) than indicated in radiation protection guidelines. As a result, research efforts are now being directed towards identifying early predictors of lens degeneration resulting in cataractogenesis. In this study, Raman micro-spectroscopy was used to investigate the effects of varying doses of radiation, ranging from 0.01 Gy to 5 Gy, on human lens epithelial (HLE) cells which were chemically fixed 24 hrs post-irradiation...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29235975/preparing-thin-cross-sections-of-arabidopsis-roots-without-embedding
#14
Naoyuki Sotta, Toru Fujiwara
Here, we describe a method for obtaining thin cross sections of Arabidopsis thaliana roots without fixation and embedding. Roots were grown in pinholes made in a solidified growth medium, and cross sections were prepared without pretreatment. Using this method, we detected unique distributions of two polar-localized proteins-green fluorescent protein (GFP)-tagged BOR1 and NIP5;1-with less sample preparation time than conventional methods. This method is simple, rapid, and yields high-quality cross-section images that are free from artifacts commonly associated with embedding or the sample preparation procedures used in many conventional methods...
December 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29235967/effect-of-alternating-postures-on-cognitive-performance-for-healthy-people-performing-sedentary-work
#15
Bernhard Schwartz, Jay M Kapellusch, Andreas Schrempf, Kathrin Probst, Michael Haller, Arnold Baca
Prolonged sitting is a risk factor for several diseases and the prevalence of worksite-based interventions such as sit-to-stand workstations is increasing. Although their impact on sedentary behaviour has been regularly investigated, the effect of working in alternating body postures on cognitive performance is unclear. To address this uncertainty, forty-five students participated in a two-arm, randomized controlled cross-over trial under laboratory conditions. Subjects executed validated cognitive tests (working speed, reaction time, concentration performance) either in sitting or alternating working postures on two separate days (ClinicalTrials...
December 13, 2017: Ergonomics
https://www.readbyqxmd.com/read/29235929/the-nomological-network-of-emotion-knowledge-and-emotion-understanding-in-adults-evidence-from-two-new-performance-based-tests
#16
Katja Schlegel, Klaus R Scherer
Emotion understanding, which can broadly be defined as expertise in the meaning of emotion, is a core component of emotional intelligence and facilitates better intra- and interpersonal outcomes. However, to date only very few standard tests to measure emotion understanding in healthy adults exist. Here, we present two new performance-based tests that were developed and are scored based on componential emotion theory and large-scale cross-cultural empirical findings. These instruments intend to measure facets of emotion understanding that are not included in existing tests...
December 13, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/29235904/molecular-modeling-and-docking-studies-of-the-oxytocin-receptor
#17
Gloria Antobreh, Istvan Enyedy, Aina Westrheim Ravna
AIM: Low oxytocin (OT) level is involved in a number of psychiatric diseases, indicating that OT could be used to aid treating these disorders. OT itself is unable to cross the blood-brain barrier, and development of new small nonpeptide drugs targeting the OT receptor (OXTR) may be beneficial for treating mental disorders. Results & methodology: Three OXTR models were constructed based on crystallized homologous proteins (Protein Data Bank [PDB]: 2Y00, PDB: 4BVN and PDB: 4LDE). The abilities of the models to discriminate between true binders and decoys were analyzed using receiver operating characteristics curves, and the 4LDE-based model gave the best result...
December 13, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29235877/cooperative-pd-cu-catalysis-multicomponent-synthesis-of-tetrasubstituted-imidazolones-from-methyl-%C3%AE-isocyanoacetates-primary-amines-and-aryl-vinyl-iodides
#18
Antonin Clemenceau, Qian Wang, Jieping Zhu
Three-component reaction of methyl α,α-disubstituted α-isocyanoacetates, primary amines, and aryl(vinyl) halides in the presence of Pd(OAc)2 (0.05 equiv) and Cu2O (1.0 equiv) provided 2,3,5,5-tetrasubstituted imidazolones via the formation of three chemical bonds. A copper-mediated migratory insertion of the isocyano group into the N-H bond of the amine followed by lactamization and Pd-catalyzed cross-coupling of the in situ generated amidinyl copper species with aryl(vinyl) halides accounted for the reaction outcome...
December 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/29235869/correction-to-organocatalytic-enantioselective-cross-aldol-reaction-of-o-hydroxyarylketones-and-trifluoromethyl-ketones
#19
Pei Wang, Hong-Feng Li, Jia-Zhen Zhao, Zhi-Hong Du, Chao-Shan Da
No abstract text is available yet for this article.
December 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/29235719/prevalence-and-sociodemographic-correlates-of-routine-breast-cancer-screening-practices-among-migrant-australian-women
#20
Michelle Lam, Cannas Kwok, Mi-Joung Lee
OBJECTIVE: To evaluate breast cancer screening (BCS) practice and explore the relationship between sociodemographic factors and breast awareness (BA), clinical breast examination (CBE) and mammography in migrant-Australian women. METHOD: Secondary analysis was performed on the pooled sample (n=1,744) from five cross-sectional studies of BCS rates among immigrant-Australian women, and the associated sociodemographic factors. RESULTS: Only 19% of women participated in routine BA, 27...
December 13, 2017: Australian and New Zealand Journal of Public Health
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