keyword
https://read.qxmd.com/read/38293884/-primary-testicular-nk-t-cell-lymphoma-case-report-and-review-of-literature
#1
REVIEW
Alejandro Avilés-Salas, Andrea Nallely Heredia-Jara, Laura Felisa Peña-Carvajalino, José Gregorio Chanona-Vilchis, José Ángel Arriaga-Marroquín, Myrna Candelaria
Natural killer/T cell lymphomas chiefly involving the midline facial structures including the nasal cavity or nasopharyns are a relatively rare type of non-Hodgkin's lymphoma. Apart from the upper respiratory tract, the disease occasionally presents in certain extranodal sites, such as the central nervous system, skin, gastrointestinal tract, or testes. We report a case of natural killer NK/T cell lymphoma as a testicular tumor in a 36-year-old man with a history of progressive swelling of his right testicle...
March 2023: Revista Médica de Chile
https://read.qxmd.com/read/38167647/ofatumumab-as-part-of-reduced-intensity-conditioning-in-high-risk-b-cell-lymphoma-patients-final-long-term-analysis-from-a-prospective-multicenter-phase-ii-trial
#2
JOURNAL ARTICLE
Mónica Cabrero, Lucia López-Corral, Isidro Jarque, Fátima de la Cruz-Vicente, Estefanía Pérez-López, David Valcárcel, Jaime Sanz, Ildefonso Espigado, Guillermo Ortí, Carmen Martín-Calvo, Javier de la Serna, Dolores Caballero
Curative potential of allogeneic transplantation (AlloSCT) in high-risk non-Hodgkin lymphoma (NHL) could be enhanced by the integration of Ofatumumab (OFA), a 2nd generation anti-CD20 moAb, due to an antitumor effect and a role over graft-versus-host disease (GVHD). In this phase II trial (NCT01613300), we investigated safety and effectiveness of OFA-based reduced intensity conditioning (RIC). High-risk B-cell NHL patients with chemorrefractory disease or post-autologous SCT relapse were eligible. OFA was added to a standard RIC regimen...
January 2, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38150195/-non-hodgkin-large-b-cell-lymphoma-of-the-bile-duct-mimicking-a-klatskin-tumor-case-report
#3
JOURNAL ARTICLE
Clara María Cascio Baccanelli, Andrea Melissa Sian, Pedro Vicente Uad, Jeremias Goransky Patiño
The obstruction of the bile duct secondary to non-Hodgkin lymphoma is extremely rare. That's why we present the case of a 63-year-old female patient who sought medical attention due to jaundice, dark urine, acholia, and weakness. Laboratory results showed a cholestatic pattern, and an ultrasound revealed dilation of the intra and extrahepatic bile ducts, for which a cholangio resonance was ordered. It showed an expansive formation with ill-defined borders compromising the common hepatic duct associated with its stenosis...
December 26, 2023: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/37773174/-upper-digestive-tract-bleeding-as-a-clinical-presentation-of-non-hodgkin-s-lymphoma
#4
JOURNAL ARTICLE
René Medina-Marroquín, Iván González-Godínez, Carlos de Jesús Maldonado-López, Ana Cristina Calzada-Rascón
BACKGROUND: Non-Hodgkin's lymphoma (NHL) is a group of malignant tumors of the nodal and extranodal lymphoid tissues, and it is associated with autoimmune diseases, mainly rheumatoid arthritis (RA). Extra nodal presentation is observed in 40%, mainly affecting the gastrointestinal tract in 3% of cases, with bleeding in the digestive tract being a rare cause of clinical presentation that requires a detailed diagnostic approach. CLINICAL CASE: 55-year-old female with a history of RA, admitted to an internal medicine service due to bleeding in the digestive tract; patient presented clinical data of deep vein thrombosis in the left pelvic limb and consumptive syndrome under study...
September 4, 2023: Revista Médica del Instituto Mexicano del Seguro Social
https://read.qxmd.com/read/37598981/exophthalmos-and-ocular-pain-as-clinical-debut-of-intracranial-hodgkin-s-lymphoma-at-diagnosis
#5
E Barrero Ruíz, R Carrasco Moro
Intracranial involvement in Hodgkin's Lymphoma (HL) is extremely unusual, especially at the time of diagnosis. Because of its non-specific radiological behaviour, it can be confused with more common entities with a radically different prognosis. Pathologically, large and bi-nucleated cells, called Reed-Sternberg cells, embedded in an inflammatory network. In this report we describe the clinical case of a patient, with no medical history, with left ocular pain and exophthalmos as presetation of intracranial HL at diagnosis and review the most current literature...
August 18, 2023: Archivos de la Sociedad Española de Oftalmología
https://read.qxmd.com/read/37379549/-hodgkin-s-lymphoma-sensitive-and-autonomic-neuropathy-as-a-paraneoplastic-manifestation
#6
Martín Milanesio, Sofía Vera, Ana G Sturich, Luciana A Guanchiale, Sebastián Figueroa Bonaparte, Ana L Basquiera
Hodgkin lymphoma (HL) comprises a heterogeneous group of lymphoid neoplasms whose origin lies in B lymphocytes. The neurological manifestations of this pathology are infrequent, and may arise from direct invasion of neoplastic cells to the nervous system, or indirectly, through paraneoplastic syndromes or as a complication of treatment. Among the neurological paraneoplastic syndromes that affect patients with HL, paraneoplastic cerebellar degeneration is the most common. Other few cases include limbic encephalitis, sensory, motor, and autonomic neuronopathy...
2023: Medicina
https://read.qxmd.com/read/37093942/-not-available
#7
JOURNAL ARTICLE
Leopoldo Santiago-Sanabria, Julieta Garza-Arrieta, Gina Daniela Porras-Ibarra, Montserrat Malfavón-Farias
OBJETIVOS: reportar un caso de linfoma no Hodgkin de células B primario de mama (LPM) y realizar una revisión de la literatura de su diagnóstico y tratamiento. Materiales y métodos: se reporta el caso de una paciente de 80 años que acudió a una institución privada de referencia en México por un LPM. Además, se diagnosticó un melanoma primario de hígado, mediante biopsia dirigida y estudio de patología. La paciente recibió tratamiento con R-CHOP (rituximab, ciclofosfamida, doxorrubicina, vincristina y prednisona), cuadrantectomía, resección de cadenas ganglionares y radioterapia...
March 30, 2023: Revista Colombiana de Obstetricia y Ginecología
https://read.qxmd.com/read/37005121/diagnostic-role-of-cxcl13-biomarker-in-primary-sjogren-s-syndrome-patients-with-parotid-non-hodgkin-s-lymphoma-complication
#8
JOURNAL ARTICLE
Maria Badarinza, Oana Serban, Lavinia Maghear, Michael Andrei Pelea, Roxana-Ioana Rosca, Daniela Fodor, Bogdan Stancu
INTRODUCTION: Serum biomarkers are important predictive factors for development of parotid non-Hodgkin's lymphoma (NHL) complication in primary Sjogren's syndrome (pSS) patients. The aim was to evaluate the diagnostic accuracy of serum CXCL13 chemokine in pSS patients with parotid NHL complication. MATERIAL AND METHODS: Serum CXCL13 chemokine was assessed in 33 patients with pSS [7 with parotid NHL complication (pSS+NHL subgroup) and 26 without NHL (pSS-NHL subgroup)] and 30 healthy subjects...
March 31, 2023: Medicina Clínica
https://read.qxmd.com/read/36705982/cholestatic-syndrome-as-a-presentation-of-non-hodgkin-lymphoma-a-pediatric-case-report
#9
JOURNAL ARTICLE
María V Rojas Ortiz, Lucía Queizan, Juliana Moscato, Ernestina Sarmiento, Fabián Salgueiro
Cholestatic jaundice is due to an alteration in conjugated bilirubin secretion; a possible cause is an al- tered bile flow resulting from an obstruction of the extrahepatic bile duct. A lymphoma is the third most common neoplasm in pediatrics, while pancreatic tumors are rare and mostly benign. The clinical mani- festations of retroperitoneal tumors are not very specific and are usually late, so a high level of clinical suspicion is required. The objective of this study is to describe the case of a 7-year-old boy with cholestatic syndrome with a tumor in the head of the pancreas compressing the extrahepatic bile duct...
August 1, 2023: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/36370191/impact-of-pre-and-or-post-autologous-stem-cell-transplantation-exposure-to-brentuximab-vedotin-on-survival-outcomes-in-patients-with-high-risk-hodgkin-lymphoma
#10
JOURNAL ARTICLE
Carmen Martínez, Manuel Espeso de Haro, Samuel Romero, Antonio Gutiérrez, Eva Domingo-Domènech, Ana P González-Rodríguez, Izaskun Zeberio, María Paz Martínez-Badas, Antonia Rodríguez-Izquierdo, Cecilia Carpio, Mariana Bastos-Oreiro, José Ángel Hernández-Rivas, Rolando Vallansot, Nicholas Kelleher, Francisco J Díaz-Gálvez, Tamara Torrado, Arturo Pereira, Ramón García-Sanz
The AETHERA trial demonstrated that brentuximab vedotin (BV) consolidation after autologous stem cell transplantation (ASCT) in patients with Hodgkin lymphoma (HL) at high risk of relapse/progression increases progression-free survival (PFS). Patients previously exposed to BV were excluded from that trial. However, BV alone or in combination with chemotherapy is frequently used as front-line treatment and/or pre-ASCT salvage therapy. We analyzed data from 156 patients with high-risk HL who underwent ASCT with (BV-CON, n = 62) or without (non-BV, n = 94) BV consolidation...
February 2023: Annals of Hematology
https://read.qxmd.com/read/36333092/primary-central-nervous-system-hodgkin-lymphoma-a-case-report-and-review-of-the-literature
#11
REVIEW
David Aliaga, Juan Mayorga, Franscisco Verdú-López, José María Gallego, Laura Castellá, Vicente Sabater
Central nervous system (CNS) involvement in the context of relapsed/refractory Hodgkin lymphoma (HL) is a quite rare, but well-known complication. Nevertheless, primary CNS-HL is an exceedingly rare condition, which diagnosis is based on well-defined morphological and immunohistochemical features, in addition to isolated involvement of the CNS. In spite of limited casuistry (just over twenty cases reported in the literature), available data agree that primary and isolated CNS-HL, when treated with a combination of surgery followed by some form of adjuvant therapy (radiotherapy±chemotherapy), carries a better prognosis than those cases with CNS involvement in the context of relapsed/refractory HL or those with CNS non-Hodgkin lymphoma...
2022: Neurocirugía (English Edition)
https://read.qxmd.com/read/35676058/sciatic-and-median-nerve-neurolymphomatosis-as-initial-presentation-of-b-cell-lymphoma
#12
JOURNAL ARTICLE
D Barahona, I Adlerstein, J Donoso, F Mercado
Neurolymphomatosis (NL) is the infiltration of cranial nerves or nerves and roots from the peripheral nervous system by lymphoma, usually by B-cell non-Hodgkin's lymphoma. It is uncommon as initial presentation of the disease and can lead to extremely heterogeneous clinical manifestations. We report the case of a 72-year old male who presented with numbness of the right hand, progressive weakness in both lower limbs and weight loss. 18F-FDG PET/CT showed bilateral hypermetabolic adrenal masses, gastric ulcer, small hypermetabolic adenopathies, multiple focal bone marrow uptake and intense uptake in both sciatic nerves and right median nerve...
May 2022: Radiología
https://read.qxmd.com/read/34962734/-primary-effusion-lymphoma-with-multisystemic-extracavitary-involvement-in-hiv-negative-diagnosed-by-autopsy
#13
JOURNAL ARTICLE
Martín Milanesio, Ana Victoria Sánchez, Luciana Guanchiale, Ruth Lía Kaplan
Introduction: Primary effusion lymphoma is a low-frequency and high-grade non-Hodgkin lymphoma caused by the Human Herpes virus 8. It mainly affects individuals infected with the human immunodeficiency virus (HIV), although it has also been described in HIV-negative cases. It is characterized by the presence of a malignant lymphomatous effusion in the different serous cavities, the pleural cavity being the most affected. Involvement outside the serosae is very rare. Diagnosis is made by analysis of the fluid accumulated in the serosae or by biopsy of the same, demonstrating the presence of characteristic neoplastic lymphocytes...
December 28, 2021: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/34913634/-lymphoma-with-signet-ring-morphology-pathology-with-distinctive-differential-diagnoses
#14
JOURNAL ARTICLE
Oscar Enrique Sánchez-Castro, Juan José Navarrete-Pérez, Elizabeth Angélica Retana-Flores, Juan Carlos León-Contreras, Javier Alejandro Teco-Cortes
Background: Signet-ring cell lymphoma is a rare entity that simulates epithelial neoplasms, sarcomas and reactive histiocytes conditions. It represents a morphological variant of non-Hodgkin's lymphomas, its diagnosis can represent a challenge, therefore it should be considered in complementary studies. Objective: The aim of this work is to show a case with a very rare morphology and to emphasize the importance of awareness this entity and avoid mistakes in its diagnosis...
November 1, 2021: Revista Médica del Instituto Mexicano del Seguro Social
https://read.qxmd.com/read/34510996/-bcl2-translocation-in-high-grade-b-cell-lymphoma-nos-dh-th-is-associated-with-reduced-progression-free-survival
#15
JOURNAL ARTICLE
Sonia Gonzalez de Villambrosia, Mariana Bastos, Javier Menarguez Palanca, Jorge Gayoso Cruz, José-Tomás Navarro, Gustavo Tapia, Sara Alvarez Alonso, Alejandro Martin, Oscar Blanco, Pau Abrisqueta, Josep Castellvi, Ana García-Noblejas, Reyes Arranz, Magdalena Adrados, Andrés López, Santiago Montes-Moreno
High Grade B Cell Lymphoma, NOS, and High Grade B Cell Lymphoma with Dual Hit or Triple Hit have been recently recategorized in the 2016 revision of the WHO classification of lymphoid neoplasms. In this study we have characterized the genetic, histopathological, and clinical features of a series of this type of lymphoid neoplasia (17 HGBCL NOS and 53 HGBCL DH/TH).HGBCL NOS showed better response to first line treatment than HGBCL with DH/TH but no significant differences in PFS or OS were found between the two categories...
January 2022: Leukemia & Lymphoma
https://read.qxmd.com/read/34425968/semiquantitative-analysis-of-interim-18-f-fdg-pet-is-superior-in-predicting-outcome-in-hodgkin-lymphoma-patients-compared-to-visual-analysis
#16
JOURNAL ARTICLE
T Ribeiro, A Marques, G Ferreira, C Castro, M Tavares, A Espírito-Santo, C Moreira, J Mariz
PURPOSE: To investigate the prognostic value of interim PET (PETi) in adult HL patients, comparing visual with semiquantitative analysis. MATERIAL AND METHODS: Retrospective analysis of Hodgkin's lymphoma (HL) patients diagnosed between 2012 and 2016 in the Onco-hematology Department of Instituto Português de Oncologia - Porto (median follow-up: 46.5 months [2.6-66.4]). Fifty-eight patients with available PET at diagnosis (PET0) and PETi data were included. PETi scans were analyzed according to Deauville 5-point scale (5-PS), and cut-off values for changes in maximum standardized uptake value [SUVmax], peak SUV [SUVpeak], metabolic tumour volume [MTV] and total lesion glycolysis index [TLG] between PETi and PET0 were computed using ROC analysis...
September 2021: Revista española de medicina nuclear e imagen molecular
https://read.qxmd.com/read/34324483/mexican-consensus-on-hodgkin-s-lymphoma
#17
JOURNAL ARTICLE
José L Álvarez-Vera, Jocelyn Aguilar-Luevano, Luisa M Alcívar-Cedeño, Luara L Arana-Luna, Luis Arteaga-Ortiz, Pamela E Báez-Islas, Ana Carolina-Reynoso, Gabriela Cesarman-Maus, José A De la Peña-Celaya, María E Espitia-Ríos, Denisse J Fermín-Caminero, Willy Flores-Patricio, Alinka S García-Camacho, Pedro G Guzmán-Mora, Ana K Hernández-Colín, Eleazar Hernández-Ruiz, Wilfrido Herrera-Olivares, Elvia Jacobo-Medrano, Sergio J Loera-Fragoso, Juan P Macías-Flores, Mario A Martínez-Ramírez, Liliana Medina-Guzmán, Andrea I Milán-Salvatierra, Leire Montoya-Jiménez, Javier de J Morales-Adrián, Aldo Mujica-Martínez, Lorena Nava-Villegas, Juan J Orellana-Garibay, Orlando G Palma-Moreno, Juan M Pérez-Zúñiga, Karen D Pérez-Gómez, Yayra M Pichardo-Cepín, Flavio Rojas-Castillejos, Eduardo Romero-Martínez, Hilda Romero-Rodelo, Adela Segura-García, Karina Silva-Vera, Ana L Tapía-Enríquez, Óscar Teomitzi-Sánchez, Fredy Tepepa-Flores, Shendel P Vilchis-González, Atenas Villela-Peña, Lidia V Guerra-Alarcón, Rodrigo Reséndiz-Olea, Luisa Banda-García, Eugenia P Paredes-Lozano, Martha Alvarado-Ibarra
El linfoma de Hodgkin (LH) se debe a la transformación clonal de células originadas en los linfocitos B, lo que genera las células binucleadas patognomónicas de Reed-Sternberg. El LH es una enfermedad de células B con una distribución bimodal, con mayor incidencia en la adolescencia y la tercera década de la vida y un segundo pico en personas mayores de 55 años. Las células del LH clásico habitualmente sufren una reprogramación de la expresión génica, ya que pierden la expresión de la mayoría de los genes típicos de las células B y han adquirido la expresión de múltiples genes que son típicos de otros tipos de células del sistema inmunitario...
2021: Gaceta Médica de México
https://read.qxmd.com/read/34196636/mexican-consensus-on-hodgkin-s-lymphoma
#18
JOURNAL ARTICLE
José L Álvarez-Vera, Jocelyn Aguilar-Luevano, Luisa M Alcívar-Cedeño, Luara L Arana-Luna, Luis Arteaga-Ortiz, Pamela E Báez-Islas, Ana Carolina-Reynoso, Gabriela Cesarman-Maus, José A De la Peña-Celaya, María E Espitia-Ríos, Denisse J Fermín-Caminero, Willy Flores-Patricio, Alinka S García-Camacho, Pedro G Guzmán-Mora, Ana K Hernández-Colín, Eleazar Hernández-Ruiz, Wilfrido Herrera-Olivares, Elvia Jacobo-Medrano, Sergio J Loera-Fragoso, Juan P Macías-Flores, Mario A Martínez-Ramírez, Liliana Medina-Guzmán, Andrea I Milán-Salvatierra, Leire Montoya-Jiménez, Javier de J Morales-Adrián, Aldo Mujica-Martínez, Lorena Nava-Villegas, Juan J Orellana-Garibay, Orlando G Palma-Moreno, Juan M Pérez-Zúñiga, Karen D Pérez-Gómez, Yayra M Pichardo-Cepín, Flavio Rojas-Castillejos, Eduardo Romero-Martínez, Hilda Romero-Rodelo, Adela Segura-García, Karina Silva-Vera, Ana L Tapía-Enríquez, Óscar Teomitzi-Sánchez, Fredy Tepepa-Flores, Shendel P Vilchis-González, Atenas Villela-Peña, Lidia V Guerra-Alarcón, Rodrigo Reséndiz-Olea, Luisa Banda-García, Eugenia P Paredes-Lozano, Martha Alvarado-Ibarra
Hodgkin's lymphoma is due to the clonal transformation of cells originating from B lymphocytes, generating the pathognomonic binucleate Reed-Sternberg cells. Hodgkin's lymphoma is a B cell disease with a bimodal distribution, with higher incidence in adolescence and the third decade of life, showing a second peak in people over 55 years of age. Classic Hodgkin lymphoma cells routinely undergo gene expression reprogramming, as they lose the expression of most of the typical B-cell genes and acquire the expression of multiple genes that are typical of other types of cells in the immune system...
2021: Gaceta Médica de México
https://read.qxmd.com/read/33947644/semiquantitative-analysis-of-interim-18-f-fdg-pet-is-superior-in-predicting-outcome-in-hodgkin-lymphoma-patients-compared-to-visual-analysis
#19
JOURNAL ARTICLE
Teresa Ribeiro, Ana Marques, Gonçalo Ferreira, Clara Castro, Márcio Tavares, Ana Espírito-Santo, Cláudia Moreira, José Mariz
PURPOSE: To investigate the prognostic value of interim PET (PETi) in adult HL patients, comparing visual with semiquantitative analysis. MATERIAL AND METHODS: Retrospective analysis of Hodgkin's Lymphoma (HL) patients diagnosed between 2012 and 2016 in the Onco-Hematology Department of Instituto Português de Oncologia - Porto (median follow-up: 46.5 months [2,6-66,4]). Fifty-eight patients with available PET at diagnosis (PET0) and PETi data were included. PETi scans were analysed according to Deauville 5-point scale (5-PS), and cut-off values for changes in maximum standardized uptake value [SUVmax], peak SUV [SUVpeak], metabolic tumour volume [MTV] and total lesion glycolysis index [TLG] between PETi and PET0 were computed using ROC analysis...
May 1, 2021: Revista Española de Medicina Nuclear e Imagen Molecular
https://read.qxmd.com/read/33844761/-prognostic-value-of-interim-pet-ct-in-non-hodgkin-lymphoma
#20
JOURNAL ARTICLE
David Ladrón de Guevara, Sebastián Bernard, Susana Manhood, Sophia Melani, Fernando Yerovi, María de Los Ángeles Rodríguez
BACKGROUND: The prognosis of Non-Hodgkin Lymphoma (NHL) depends on the type of lymphoma, the extension of the disease and the response to therapy. AIM: To evaluate the prognostic value of pretreatment and interim PET/CT compared to classic prognosis factors and body composition measurement (sarcopenia, adipopenia) in patients with recently diagnosed NHL. MATERIAL AND METHODS: Patients with recently diagnosed NHL who had staging 18F-FDG PET/CT performed between December 2008 and August 2018 were selected...
November 2020: Revista Médica de Chile
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