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QTc prolongation

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https://www.readbyqxmd.com/read/29775246/tramadol-hydrochloride-at-steady-state-lacks-clinically-relevant-qtc-interval-increases-in-healthy-adults
#1
Joseph Massarella, Jay Ariyawansa, Jaya Natarajan, Stephan Francke, Thomas Murtaugh, Byron DeLemos, Subusola Vaughan, Sergio Fonseca
We evaluated the effects of therapeutic and supratherapeutic doses of tramadol hydrochloride on the corrected QT (QTc) interval in healthy adults (aged 18-55 years) in a randomized, phase I, double-blind, placebo- and positive-controlled, multiple-dose, 4-way crossover study. Participants were randomized to receive 1 of 4 treatments (A-D), 1 each in 4 treatment periods (1-4), separated by a washout period (7-15 days). Treatment A comprised tramadol 400 mg (therapeutic dose) on days 1 through 3, tramadol 100 mg and moxifloxacin-matched placebo on day 4, and placebo on all 4 days...
May 18, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29774881/-effect-of-down-regulation-of-iks-repolarization-reserve-on-ventricular-arrhythmogenesis-in-a-guinea-pig-model-of-cardiac-hypertrophy
#2
Hegui Wang, Ting Huang, Zheng Wang, Nannan Ge, Yongsheng Ke
To observe the changes of rapidly activated delayed rectifier potassium channel (IKr) and slowly activated delayed rectifier potassium channel (IKs) in cardiac hypertrophy and to evaluate the effects of IKr and IKs blocker on the incidence of ventricular arrhythmias in guinea pigs with left ventricular hypertrophy (LVH).
 Methods: Guinea pigs were divided into a sham operation group and a left ventricular hypertrophy (LVH) group. LVH model was prepared. Whole cell patch-clamp technique was used to record IKr and IKs tail currents in a guinea pig model with LVH...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774373/cardiovascular-system-changes-in-rheumatoid-arthritis-patients-with-continued-low-disease-activity
#3
Małgorzata Biskup, Wojciech Biskup, Maria Majdan, Bożena Targońska-Stępniak
Systemic inflammation and disease activity seem to contribute to excessive prevalence of cardiovascular (CV) diseases (CVDs) in patients with rheumatoid arthritis (RA). The objective of the study was to assess chosen CV parameters in RA patients who have continuous low disease activity. The study group consisted of 70 RA patients without known CVD and 33 healthy controls, of a comparable age. All RA patients had continued low disease activity (DAS28 ≤ 3.2) from 2 to 7 years. The groups were assessed for: blood pressure, serum amino-terminal pro-brain natriuretic peptide (NT-proBNP), carotid intima media thickness (cIMT), electrocardiography (ECG), ejection fraction (EJ) and diastolic dysfunction (E/A ratio) in echocardiography...
May 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29761176/androgen-deprivation-therapy-is-associated-with-prolongation-of-qtc-interval-in-men-with-prostate-cancer
#4
Thiago Gagliano-Jucá, Thomas G Travison, Philip W Kantoff, Paul L Nguyen, Mary-Ellen Taplin, Adam S Kibel, Grace Huang, Richelle Bearup, Haley Schram, Robert Manley, Yusnie M Beleva, Robert R Edwards, Shehzad Basaria
Context: Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with increased cardiovascular mortality and sudden cardiac death, with some events occurring early after initiation of ADT. Testosterone levels are inversely associated with corrected QT (QTc) interval duration; therefore, prolongation of QTc duration could be responsible for some of these events during ADT. Objective: To evaluate changes in QTc duration during ADT. Design and Interventions: A 6-month prospective cohort study that enrolled men with PCa about to undergo ADT (ADT group) and a control group of men who previously underwent prostatectomy for PCa and never received ADT (non-ADT group)...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29759841/prolonged-ventricular-conduction-and-repolarization-during-right-ventricular-stimulation-predicts-ventricular-arrhythmias-and-death-in-patients-with-cardiomyopathy
#5
Freddy Del-Carpio Munoz, S Michael Gharacholou, Christopher G Scott, Vuyisile T Nkomo, Francisco Lopez-Jimenez, Yong-Mei Cha, Thomas M Munger, Paul A Friedman, Samuel J Asirvatham
OBJECTIVES: The goal of this study was to evaluate whether prolonged ventricular conduction (paced QRS) and repolarization (paced QTc) times observed during ventricular stimulation predict ventricular arrhythmic events and death. BACKGROUND: Abnormal ventricular conduction and repolarization can predispose patients to ventricular arrhythmias. METHODS: Consecutive patients with left ventricular dysfunction (ejection fraction <50%) undergoing electrophysiology studies from January 2002 until May 2014 were identified at Mayo Clinic (Rochester, Minnesota)...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759541/the-phenotypic-spectrum-of-a-mutation-hotspot-responsible-for-the-short-qt-syndrome
#6
Dan Hu, Yang Li, Jiancheng Zhang, Ryan Pfeiffer, Michael H Gollob, Jeff Healey, Daniel Toshio Harrell, Naomasa Makita, Haruhiko Abe, Yaxun Sun, Jihong Guo, Li Zhang, Ganxin Yan, Douglas Mah, Edward P Walsh, Harris B Leopold, Carla Giustetto, Fiorenzo Gaita, Agnieszka Zienciuk-Krajka, Andrea Mazzanti, Silvia G Priori, Charles Antzelevitch, Hector Barajas-Martinez
OBJECTIVES: This study sought to evaluate the phenotypic and functional expression of an apparent hotspot mutation associated with short QT syndrome (SQTS). BACKGROUND: SQTS is a rare channelopathy associated with a high risk of life-threatening arrhythmias and sudden cardiac death (SCD). METHODS: Probands diagnosed with SQTS and their family members were evaluated clinically and genetically. KCNH2 wild-type (WT) and mutant genes were transiently expressed in HEK293 cells, and currents were recorded using whole-cell patch clamp and action potential (AP) clamp techniques...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29746871/discrete-typing-units-of-trypanosoma-cruzi-detected-by-real-time-pcr-in-chilean-patients-with-chronic-chagas-cardiomyopathy
#7
Catalina Muñoz-San Martín, Inés Zulantay, Miguel Saavedra, Cristián Fuentealba, Gabriela Muñoz, Werner Apt
Chagas disease is a major public health problem in Latin America and has spread to other countries due to immigration of infected persons. 10-30% of patients with chronic Chagas disease will develop cardiomyopathy. Chagas cardiomyopathy is the worst form of the disease, due to its high morbidity and mortality. Because of its prognostic value and adequate medical monitoring, it is very important to identify infected people who could develop Chagas cardiomyopathy. The aim of this study was to determine if discrete typing units (DTUs) of Trypanosoma cruzi are related to the presence of heart disease in patients with chronic Chagas disease...
May 7, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29740922/association-of-hypoglycaemia-and-cardiac-arrhythmia-risk-in-patients-with-diabetes-mellitus-a-systematic-review-and-meta-analysis
#8
Claire Fitzpatrick, Sudesna Chatterjee, Samuel Seidu, Danielle H Bodicoat, G Andre Ng, Melanie J Davies, Kamlesh Khunti
AIMS: Hypoglycaemia is associated with increased cardiovascular risk amongst individuals with diabetes mellitus. It has been hypothesised that hypoglycaemia may trigger autonomic changes leading to increased cardiac arrhythmia risk. We conducted a systematic review and meta-analysis to explore this association. MATERIALS AND METHODS: Ovid Medline, Embase, Scopus, Web of Science and Cochrane were searched from inception to October 10, 2017. We included studies of adults with diabetes (Type 1 or Type 2) which compared acute electrocardiogram (ECG) changes during episodes of hypoglycaemia and euglycaemia...
May 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29738315/diagnosis-and-treatment-of-histoplasmosis-in-solid-organ-transplant-patients
#9
Kiran Gajurel, Reshika Dhakal, Stan Deresinski
PURPOSE OF REVIEW: Unlike immunocompetent hosts, solid organ transplant (SOT) recipients with posttransplant histoplasmosis (PTH) often present with disseminated disease and have an attributable mortality of approximately 10%. In this review, we discuss currently available diagnostic tests and treatment strategies in PTH. RECENT FINDINGS: None of the available tests have a 100% diagnostic accuracy. Histoplasma antigen assays are the most sensitive commercially available tests...
May 5, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29733094/safety-profile-of-intraoperative-methadone-for-analgesia-after-major-spine-surgery-an-observational-study-of-1-478-patients
#10
Lauren K Dunn, Sandeep Yerra, Shenghao Fang, Mark F Hanak, Maren K Leibowitz, Salome B Alpert, Siny Tsang, Marcel E Durieux, Edward C Nemergut, Bhiken I Naik
OBJECTIVE: To investigate the incidence of perioperative adverse events in patients receiving intravenous methadone for major spine surgery. DESIGN: Retrospective review of perioperative records from March 2011 and February 2016. SETTING: University of Virginia Healthsystem. PATIENTS: Adult patients undergoing elective spinal fusion of two or more levels. MAIN OUTCOME MEASURES: Incidence of respiratory depression, time to extubation, hypotension, hypoxemia, reintubation, cardiac complications, and death...
March 2018: Journal of Opioid Management
https://www.readbyqxmd.com/read/29731619/association-between-a-frailty-index-based-on-common-laboratory-tests-and-qtc-prolongation-in-older-adults-the-rugao-longevity-and-ageing-study
#11
Teng Ma, Jian Cai, Yin-Sheng Zhu, Xue-Feng Chu, Yong Wang, Guo-Ping Shi, Zheng-Dong Wang, Shun Yao, Xiao-Feng Wang, Xiao-Yan Jiang
Background: Risk factors for heart rate-corrected QT interval (QTc) proglongation should be explored to stratify high-risk individuals to aid the prevention of incident cardiovascular events and mortality. The diversity of risk factors for QTc prolongation suggests that use of the frailty index (FI), indicating general health deficits, may be an effective approach, especially in the elderly, to identify the risk of QTc prolongation. Methods: We used the data of 1,780 individuals aged 70-87 years from the Rugao Longevity and Ageing Study (RuLAS), a community-based longitudinal study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29730876/qtc-prolongation-and-ventricular-trigemini-with-asenapine-a-case-report
#12
Jesjeet Singh Gıll, Ahmad Hatim Sulaıman
Asenapine is one of the newer atypical antipsychotics on the market. It is a sublingually administered drug that is indicated for the treatment of both schizophrenia and bipolar disorder, and is considered to be safe and well tolerated. Herein, we report a 71-year-old female with a history of bipolar disorder who had ventricular trigemini and experienced a large increase in her QTc interval after starting treatment with asenapine. These changes ceased following withdrawal of asenapine. In this case report, we discuss the importance of cardiac monitoring when switching antipsychotics, even to those that are considered to have low cardiac risk...
2018: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29723224/effects-of-anthracycline-cyclophosphamide-and-taxane-chemotherapy-on-qtc-measurements-in-patients-with-breast-cancer
#13
Pedro Veronese, Denise Tessariol Hachul, Mauricio Ibrahim Scanavacca, Ludhmila Abrahão Hajjar, Tan Chen Wu, Luciana Sacilotto, Carolina Veronese, Francisco Carlos da Costa Darrieux
AIM: Acute and subacute cardiotoxicity are characterized by prolongation of the corrected QT interval (QTc) and other measures derived from the QTc interval, such as QTc dispersion (QTdc) and transmural dispersion of repolarization (DTpTe). Although anthracyclines prolong the QTc interval, it is unclear whether breast cancer patients who undergo the ACT chemotherapy regimen of anthracycline (doxorubicin: A), cyclophosphamide (C) and taxane (T) may present with QTc, QTdc and DTpTe prolongation...
2018: PloS One
https://www.readbyqxmd.com/read/29721094/safety-of-panitumumab-irdye800cw-and-cetuximab-irdye800cw-for-fluorescence-guided-surgical-navigation-in-head-and-neck-cancers
#14
Rebecca W Gao, Nutte Teraphongphom, Esther de Boer, Nynke S van den Berg, Vasu Divi, Michael J Kaplan, Nicholas J Oberhelman, Steven S Hong, Elissa Capes, A Dimitrios Colevas, Jason M Warram, Eben L Rosenthal
Purpose: To demonstrate the safety and feasibility of leveraging therapeutic antibodies for surgical imaging. Procedures: We conducted two phase I trials for anti-epidermal growth factor receptor antibodies cetuximab-IRDye800CW (n=12) and panitumumab-IRDye800CW (n=15). Adults with biopsy-confirmed head and neck squamous cell carcinoma scheduled for standard-of-care surgery were eligible. For cetuximab-IRDye800CW, cohort 1 was intravenously infused with 2.5 mg/m2 , cohort 2 received 25 mg/m2 , and cohort 3 received 62...
2018: Theranostics
https://www.readbyqxmd.com/read/29720913/effects-of-methadone-on-corrected-q-t-interval-prolongation-in-critically-ill-children
#15
Travis S Heath, Rachel G Greenberg, Susan R Hupp, David A Turner, Christoph P Hornik, Kanecia O Zimmerman
OBJECTIVES: This study aimed to determine the association between methadone use and corrected Q-T interval (QTc) prolongation in critically ill children. METHODS: A retrospective cohort study of critically ill children receiving methadone at a tertiary care pediatric hospital was conducted. Patients younger than 19 years who had been admitted to the intensive care unit between January 1, 2009, and June 21, 2013, who had received methadone while inpatients, and who had had electrocardiograms (ECGs) performed within 30 days before and after methadone initiation were included...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29720397/increased-long-qt-and-torsade-de-pointes-reporting-on-tamoxifen-compared-with-aromatase-inhibitors
#16
Virginie Grouthier, Benedicte Lebrun-Vignes, Andrew M Glazer, Philippe Touraine, Christian Funck-Brentano, Antoine Pariente, Carine Courtillot, Anne Bachelot, Dan M Roden, Javid J Moslehi, Joe-Elie Salem
OBJECTIVE: A prolonged QTc (LQT) is a surrogate for the risk of torsade de pointes (TdP). QTc interval duration is influenced by sex hormones: oestradiol prolongs and testosterone shortens QTc. Drugs used in the treatment of breast cancer have divergent effects on hormonal status. METHODS: We performed a disproportionality analysis using the European database of suspected adverse drug reaction (ADR) reports to evaluate the reporting OR (ROR χ2 ) of LQT, TdP and ventricular arrhythmias associated with selective oestrogen receptor modulators (SERMs: tamoxifen and toremifene) as opposed to aromatase inhibitors (AIs: anastrozole, exemestane and letrozole)...
May 2, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29713819/evaluation-of-the-risk-factors-for-ventricular-arrhythmias-secondary-to-qt-prolongation-induced-by-papaverine-injection-during-coronary-flow-reserve-studies-using-a-4-fr-angio-catheter
#17
Yoshitaka Okabe, Kanichi Otowa, Yasuhito Mitamura, Hisayoshi Murai, Soichiro Usui, Shuichi Kaneko, Masayuki Takamura
Estimation of the fractional flow reserve (FFR) is considered to be an established method by which to assess stable coronary artery stenosis. Induction of maximal coronary hyperemia is important during the FFR procedure. Papaverine has been reported to increase the risk of ventricular arrhythmia (VA). The purpose of the present study was to discover predictors of papaverine-induced VAs developing during FFR measurement. A total of 213 clinically stable patients were included in the study. FFRs were determined after intracoronary papaverine administration (12 mg into the left and 8 mg into the right coronary arteries)...
April 30, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29704768/management-of-treatment-related-toxicities-in-advanced-medullary-thyroid-cancer
#18
REVIEW
Marcia S Brose, Keith C Bible, Laura Q M Chow, Jill Gilbert, Carolyn Grande, Francis Worden, Robert Haddad
Progress in the treatment of advanced medullary thyroid cancer (MTC) has resulted from the approval of 2 drugs within the past 5 years, vandetanib and cabozantinib. These multikinase inhibitors (MKIs) possess overlapping specificities for multiple kinase targets implicated in the progression of MTC. Both drugs are associated with toxicities, including hypertension, hemorrhage/perforation, diarrhea and other gastrointestinal events, several dermatologic events, and hypothyroidism. In addition, vandetanib is uniquely associated with QTc prolongation through interaction with myocardial potassium channels, and cabozantinib is uniquely associated with hand-foot skin reaction...
April 22, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29699857/prevalence-and-significance-of-notched-t-waves-in-elite-professional-cyclists
#19
Jose David Arroja, Georgios Giannakopoulos, Anna Louise Beale, Dipen Shah, Philippe Meyer
OBJECTIVES: To identify the frequency and significance of notched T-waves (NTW) in elite endurance athletes. METHODS: Professional cyclists were followed for 4 years with a clinical, electrocardiographic and echocardiographic assessment. Electrocardiograms were classified according to the presence or absence of NTWs; clinical and echocardiographic correlates were assessed. RESULTS: 42 Caucasian male cyclists were included. NTW were detected in 8 (19%) cyclists who showed significantly longer QT (461 ± 15 vs 422 ± 33 ms, p < 0...
April 22, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29698683/anticancer-drug-induced-cardiac-rhythm-disorders-current-knowledge-and-basic-underlying-mechanisms
#20
REVIEW
Joachim Alexandre, Javid Moslehi, Kevin R Bersell, Christian Funck-Brentano, Dan M Roden, Joe-Elie Salem
Significant advances in cancer treatment have resulted in decreased cancer related mortality for many malignancies with some cancer types now considered chronic diseases. Despite these improvements, there is increasing recognition that many cancer patients or cancer survivors can develop cardiovascular diseases, either due to the cancer itself or as a result of anticancer therapy. Much attention has focused on heart failure; however, other cardiotoxicities, notably cardiac rhythm disorders, can occur without underlying cardiomyopathy...
April 24, 2018: Pharmacology & Therapeutics
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