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https://www.readbyqxmd.com/read/28933103/-research-achievements-on-ginsenosides-biosynthesis-from-panax-ginseng
#1
REVIEW
Yan-Ping Lin, Mei-Ping Zhang, Kang-Yu Wang, Chun-Yu Sun, Yi Wang
Panax ginseng is one of the famous rare medicinal herbs, and ginsenosides are the main active ingredient of ginseng is ginsenoside.They can be divided into three chemotypes: oleanane type, protopanaxadiol (PPD) type and the protopanaxatriol (PPT)type. Ginsenosides possess anti-thrombotic, anti-fatigue, anti-aging, cancer control, strengthening the immune system and many other effects. Rrogress has remarkably been made in pharmacology, efficacy and blosynthesis of ginsenosides.This review covers the recent research achievements of ginsenasides, which would be helpful for the relevant researchers to get useful information...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28930275/anti-aging-and-antioxidant-potential-of-paullinia-cupana-var-sorbilis-findings-in-caenorhabditis-elegans-indicate-a-new-utilization-for-roasted-seeds-of-guarana
#2
Herbenya Peixoto, Mariana Roxo, Teresa Röhrig, Elke Richling, Xiaojuan Wang, Michael Wink
Background: Roasted seeds of Amazonian guarana (Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich in purine alkaloids, markedly caffeine, the seeds are extensively used in the Brazilian beverage industry for the preparation of soft drinks and as additives in energy drinks. Methods: To investigate the putative anti-aging and antioxidant activity of guarana, we used the model organism Caenorhabditis elegans. Chemical analyses were performed using high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS/MS)...
August 15, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28927141/catalpol-promotes-cellular-apoptosis-in-human-hct116-colorectal-cancer-cells-via-microrna-200-and-the-downregulation-of-pi3k-akt-signaling-pathway
#3
Lan Liu, Hongwei Gao, Hongbo Wang, Yuan Zhang, Weihua Xu, Sen Lin, Hongjuan Wang, Qiong Wu, Jianqiang Guo
Catalpol is an effective active ingredient that functions as a diuretic and laxative, and exhibits blood sugar-lowering, liver protective, anti-aging and anticancer effects. In traditional Chinese medicine, catalpol is believed to be Yin nourishing. The anticancer effect of catalpol on human HCT116 colorectal cancer cells were investigated and the mechanism of action was evaluated. Cellular viability was detected using an MTT assay. Caspase-3 and caspase-9 activity, cellular apoptosis and nucleic morphology were analyzed using caspase-3 and caspase-9 activity assay kits, flow cytometric assays and DAPI staining assay, respectively...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28922722/molecular-mechanisms-of-anticancer-effects-of-glucosamine
#4
REVIEW
Fatemeh Zahedipour, Razieh Dalirfardouei, Gholamreza Karimi, Khadijeh Jamialahmadi
Glucosamine is an amino sugar that is produced naturally in human body. It is an essential carbohydrate component of many cellular glycoproteins, glycolipids, and glycosaminoglycans (GAGs). This popular over-the-counter supplement is also found in the exoskeleton of crustaceans. Glucosamine and its derivatives have a long history in medicine for inflammatory conditions specially to relieve arthritis. This dietary supplement has numerous biological and pharmacological properties, including anti-inflammatory, antioxidant, anti-aging, anti-fibrotic, neuroprotective and cardioprotective activities...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28893010/evaluation-of-the-potency-of-kinetin-on-radiation-induced-behavioural-changes-in-swiss-albino-mice
#5
Vishakh Radhakrishna, Suchetha Kumari Nanilu, Ganesh Sanjeev, Jayarama Shetty, Yogish Tenkanidiyoor Somyaji, Shailaja Shivarama Moodithaya
INTRODUCTION: According to the various independent studies conducted, it is well evident fact that radiation induces oxidative stress in the living system. It is also proved that this oxidative stress will lead to the various behavioural changes such as anxiety and memory impairment. Kinetin is one of the important plant cytokine with anti-aging properties. However, very few studies were conducted to check its potential in ameliorating the behavioural changes induced by the ionizing radiation...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28887920/isolation-of-natural-products-with-anti-ageing-activity-from-the-fruits-of-platanus-orientalis
#6
Sofia Chatzigeorgiou, Quoc Dang Thai, Job Tchoumtchoua, Konstantinos Tallas, Eleni N Tsakiri, Issidora Papassideri, Maria Halabalaki, Alexios-Leandros Skaltsounis, Ioannis P Trougakos
BACKGROUND: Ageing is defined as the time-dependent decline of functional capacity and stress resistance resulting in increased morbidity and mortality. HYPOTHESIS/PURPOSE: Reportedly, these effects can be delayed by mild genetic or pharmacological activation of the main modules of the proteostasis network. STUDY DESIGN-METHODS: By employing advanced phytochemical methods we isolated natural products from the fruits of Platanus orientalis and studied (via a bio-guided approach) their effects in Drosophila flies, as well as in normal human fibroblasts...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28887692/molecular-and-biochemical-evidence-on-the-protective-role-of-ellagic-acid-and-silybin-against-oxidative-stress-induced-cellular-aging
#7
Maryam Baeeri, Solmaz Mohammadi-Nejad, Mahban Rahimifard, Mona Navaei-Nigjeh, Shermineh Moeini-Nodeh, Reza Khorasani, Mohammad Abdollahi
Aging is a natural process in living organisms that is defined by some molecular and cellular changes with time. Various causes such as mitochondrial DNA aberrations, aggregation of proteins, telomere shortening, and oxidative stress have an influential role in aging of the cells. Natural antioxidants are compounds that are potent to protect the body from detrimental effects of molecules such as free radicals. The aim of this study was to evaluate the anti-aging properties of ellagic acid (EA) and silybin (SIL), as natural antioxidant compounds on rat embryonic fibroblast (REF) cells...
September 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28884844/an-open-label-clinical-trial-assessing-the-efficacy-and-safety-of-bend-skincare-anti-aging-formula-on-minimal-erythema-dose-in-skin
#8
Nancy L Morse, Anna-Jean Reid, Marc St-Onge
BACKGROUND/PURPOSE: Sunburn and other health risks associated with excess sun exposure place huge economic burdens on societies, and create discomfort and disease within susceptible individuals. Oral supplements that reduce sunburn may be advantageous. This study evaluated the safety and efficacy of Bend Skincare Anti-Aging Formula to ameliorate sunburn induced with a solar simulator. METHODS: Subjects (n= 28) with Fitzpatrick skin phototypes I, II or III took four capsules daily of the supplement providing 1400 mg of eicosapentaenoic acid (EPA)+ docosahexaenoic acid (DHA), 120 mg of gamma-linolenic acid (GLA), 5 mg of lutein, 2...
September 8, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28878259/promoting-drp1-mediated-mitochondrial-fission-in-midlife-prolongs-healthy-lifespan-of-drosophila-melanogaster
#9
Anil Rana, Matheus P Oliveira, Andy V Khamoui, Ricardo Aparicio, Michael Rera, Harry B Rossiter, David W Walker
The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we show that upregulating Drp1-a Dynamin-related protein that promotes mitochondrial fission-in midlife, prolongs Drosophila lifespan and healthspan. We find that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan, and observe a midlife shift toward a more elongated mitochondrial morphology, which is linked to the accumulation of dysfunctional mitochondria in aged flight muscle...
September 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28857080/cardioprotection-anti-ageing-effects-of-cardiosphere-derived-cells
#10
Irene Fernández-Ruiz
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28855134/antioxidant-and-anti-aging-effects-of-acidic-extractable-polysaccharides-by-agaricus-bisporus
#11
Shangshang Li, Hui Liu, Wenshuai Wang, Xiuxiu Wang, Chen Zhang, Jianjun Zhang, Huijuan Jing, Zhenzhen Ren, Zheng Gao, Xinling Song, Le Jia
This study was designed to investigate the antioxidant and anti-aging effects of D-galatose-induced (D-gal-induced) aging mice as well as monosaccharide compositions of acidic-extractable polysaccharides (AcAPS) and its major purified fractions (AcAPS-1, AcAPS-2 and AcAPS-3) from the fruiting body of Agaricus bisporus. In the in vitro assays, AcAPS-2 showed superior scavenging activities on hydroxyl (82.98±4.67%) and DPPH (64.47±4.05%) radicals at the concentration of 1.0mg/mL than AcAPS and other polysaccharides fractions...
August 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28854150/anti-aging-effects-of-coffee
#12
Keita Takahashi, Akihito Ishigami
No abstract text is available yet for this article.
August 29, 2017: Aging
https://www.readbyqxmd.com/read/28852829/pal-12-a-new-anti-aging-hexa-peptoid-inhibits-uvb-induced-photoaging-in-human-dermal-fibroblasts-and-3d-reconstructed-human-full-skin-model-keraskin-ft%C3%A2
#13
Daeun Song, Hyeonji Park, Su-Hyon Lee, Mi Jung Kim, Eun-Joo Kim, Kyung-Min Lim
Peptoids are a class of peptidomimetics whose pharmacological activities are widely investigated owing to their remarkable biological stability. However, the utilities of peptoids as cosmetic functional ingredients have not been fully explored. Here, we investigated anti-aging effects of PAL-12, a new hexa-peptoid, on UVB-induced photoaging in human dermal fibroblasts (HDFs) and a 3D reconstituted human full skin model, Keraskin-FT™. PAL-12 suppressed matrix metalloproteinase-1 (MMP-1) expression induced by UVB irradiation along with the attenuation of MMP-1 secretion as determined by ELISA assay...
August 29, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28851637/the-antioxidative-and-anti-aging-effects-of-acidic-and-alkalic-extractable-mycelium-polysaccharides-by-agrocybe-aegerita-brig-sing
#14
Huijuan Jing, Juan Li, Jianjun Zhang, Wenshuai Wang, Shangshang Li, Zhenzhen Ren, Zheng Gao, Xinling Song, Xiuxiu Wang, Le Jia
Two extractable polysaccharides of Ac-MPS and Al-MPS were extracted from the mycelium of Agrocybe aegerita (Brig.) Sing and the in vitro antioxidant activities and in vivo anti-aging activities in a d-gal-induced aging mice were investigated in the present study. The in vitro antioxidant analysis showed that Ac-MPS showed superior scavenging effects on hydroxyl of 68.62±2.59% and DPPH of 85.19±3.26% at the concentration of 4,500μg/mL. Biochemical indices and antioxidant analysis in vivo showed that Ac-MPS had better effects in raising hepatic activities of SOD, CAT, GPx and T-AOC, inhibiting hepatic contents of LPO and MDA, as well as improving serum lipid levels of LDL-C, HDL-C, LDL-C/HDL-C, TG and TC...
August 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28844841/effect-of-resveratrol-on-cognitive-and-memory-performance-and-mood-a-meta-analysis-of-225-patients
#15
REVIEW
Mohammad Hosein Farzaei, Roja Rahimi, Shekoufeh Nikfar, Mohammad Abdollahi
Resveratrol is a natural dietary phenolic compound which is extensively present in many edible fruits, including grape, berries, pomegranates, and peanuts. Reseveratrol has a broad spectrum of biological activities including anti-aging, chemopreventive, anti-carcinogenic, anti-inflammatory and antioxidant effects and thus it is effective in related diseases. Particularly, the positive effects of resveratrol in neuropsychological diseases have been proven in in-vitro and in-vivo studies. Some clinical trials have reported that resveratrol possesses preventive and therapeutic effects in cognitive disorders...
August 24, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28843433/hdac-inhibitors-a-new-promising-drug-class-in-anti-aging-research
#16
REVIEW
Elena G Pasyukova, Alexander M Vaiserman
In the last years, epigenetic regulation of gene expression is regarded as an important factor involved in a broad spectrum of aging-associated processes including loss of physical activity, frailty and genomic instability, and in development of various pathological conditions such as atherosclerosis, type 2 diabetes, cancer, immune deficits and neurodegenerative diseases. Accordingly, inhibitors of the members of superfamilies of histone deacetylases (HDACs) have been proposed, among other drugs targeting epigenetic pathways, as a promising type of therapeutics that is able to combat aging and its manifestations...
August 24, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28839194/an-automated-compound-screening-for-anti-aging-effects-on-the-function-of-c-elegans-sensory-neurons
#17
Daphne Bazopoulou, Amrita R Chaudhury, Alexandros Pantazis, Nikos Chronis
Discovery of molecular targets or compounds that alter neuronal function can lead to therapeutic advances that ameliorate age-related neurodegenerative pathologies. Currently, there is a lack of in vivo screening technologies for the discovery of compounds that affect the age-dependent neuronal physiology. Here, we present a high-throughput, microfluidic-based assay for automated manipulation and on-chip monitoring and analysis of stimulus-evoked calcium responses of intact C. elegans at various life stages...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831863/emodin-extends-lifespan-of-caenorhabditis-elegans-through-insulin-igf-1-signaling-pathway-depending-on-daf-16-and-sir-2-1
#18
Xuan Zhao, Lulu Lu, Yonghao Qi, Miao Li, Lijun Zhou
The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16...
August 23, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28827992/anti-aging-activities-of-extracts-from-tunisian-medicinal-halophytes-and-their-aromatic-constituents
#19
A Jdey, H Falleh, S Ben Jannet, K Mkadmini Hammi, X Dauvergne, C Magné, R Ksouri
Six medicinal halophytes widely represented in North Africa and commonly used in traditional medicine were screened for pharmacological properties to set out new promising sources of natural ingredients for cosmetic or nutraceutical applications. Thus, Citrullus colocynthis, Cleome arabica, Daemia cordata, Haloxylon articulatum, Pituranthos scoparius and Scorzonera undulata were examined for their in vitro antioxidant (DPPH scavenging and superoxide anion-scavenging, β-carotene bleaching inhibition and iron-reducing tests), antibacterial (microdilution method, against four human pathogenic bacteria) and anti-tyrosinase activities...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28817730/new-approach-to-generating-insights-for-aging-research-based-on-literature-mining-and-knowledge-integration
#20
Yeondae Kwon, Yukikazu Natori, Masaru Tanokura
The proportion of the elderly population in most countries worldwide is increasing dramatically. Therefore, social interest in the fields of health, longevity, and anti-aging has been increasing as well. However, the basic research results obtained from a reductionist approach in biology and a bioinformatic approach in genome science have limited usefulness for generating insights on future health, longevity, and anti-aging-related research on a case by case basis. We propose a new approach that uses our literature mining technique and bioinformatics, which lead to a better perspective on research trends by providing an expanded knowledge base to work from...
2017: PloS One
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