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Gum disease

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https://www.readbyqxmd.com/read/28441306/orientation-of-the-upper-most-instrumented-segment-influences-proximal-junctional-disease-following-adult-spinal-deformity-surgery
#1
Renaud Lafage, Breton G Line, Sachin Gupta, Barthelemy Liabaud, Frank Schwab, Justin S Smith, Jeffrey L Gum, Christopher P Ames, Richard Hostin, Gregory M Mundis, Han Jo Kim, Shay Bess, Eric Klineberg, Virginie Lafage
STUDY DESIGN: Retrospective review of a prospective database. OBJECTIVE: To define the role of sagittal orientation of the construct at the upper instrumented levels in the development of proximal junctional kyphosis (PJK) in adult spinal deformity (ASD) patients. SUMMARY OF BACKGROUND DATA: PJK following ASD surgery remains challenging. The final alignment of the upper instrumented vertebral segments has been proposed as a risk factor for PJK, but has not been fully investigated...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28425301/development-of-a-novel-rationally-designed-antibiotic-to-inhibit-a-nontraditional-bacterial-target
#2
Pavel Dibrov, Elena Dibrov, Thane G Maddaford, Melissa Kenneth, Jordan Nelson, Craig Resch, Grant N Pierce
The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na(+)-translocating NADH:ubiquinone oxidoreductase (Na(+)-NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process. Infection by Chlamydia trachomatis significantly increased first H(+) and then Na(+) levels within the host mammalian cell...
May 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28424689/antimicrobial-and-attractant-roles-for-chemerin-in-the-oral-cavity-during-inflammatory-gum-disease
#3
Urszula Godlewska, Piotr Brzoza, Aneta Sroka, Pawel Majewski, Holger Jentsch, Martin Eckert, Sigrun Eick, Jan Potempa, Brian A Zabel, Joanna Cichy
Periodontal inflammation is one of the most common chronic inflammatory conditions in humans. Despite recent advances in identifying and characterizing oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors maintain a healthy homeostatic oral microbial community or prevent the development of a pathogenic oral microbiota remains poorly understood. An important determinant of microbiota fate is local antimicrobial proteins. Here, we report that chemoattractant protein chemerin, which we recently identified as a potent endogenous antimicrobial agent in body barriers such as the skin, is present in the oral cavity under homeostatic and inflammatory conditions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28406130/is-the-periodontal-status-a-risk-factor-for-the-development-of-psoriasis
#4
G Sarac, Y Kapicioglu, S Cayli, A Altas, S Yologlu
BACKGROUND AND OBJECTIVES: Psoriasis is a common, chronic, inflammatory, and hyperproliperative skin disease. It has been known that the infectious agents play a role in triggering and exacerbation of the disease. Periodontal diseases are chronic inflammatory gum diseases initiated by microorganisms in dental plaques. This study intended to determine the role of periodontal diseases, as chronic infective foci in psoriasis. MATERIALS AND METHODS: A total of 76 patients, who applied to Faculty of Medicine, Department of Dermatology, İnönü University, diagnosed as psoriasis and a control group consisting of 76 dermatologic patients without any systemic disease at similar age and gender were included the study...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28405165/enhancement-of-physicochemical-properties-of-nanocolloidal-carrier-loaded-with-cyclosporine-for-topical-treatment-of-psoriasis-in-vitro-diffusion-and-in-vivo-hydrating-action
#5
Siti Hajar Musa, Mahiran Basri, Hamid Reza Fard Masoumi, Norashikin Shamsudin, Norazlinaliza Salim
Psoriasis is a chronic autoimmune disease that cannot be cured. It can however be controlled by various forms of treatment, including topical, systemic agents, and phototherapy. Topical treatment is the first-line treatment and favored by most physicians, as this form of therapy has more patient compliance. Introducing a nanoemulsion for transporting cyclosporine as an anti-inflammatory drug to an itchy site of skin disease would enhance the effectiveness of topical treatment for psoriasis. The addition of nutmeg and virgin coconut-oil mixture, with their unique properties, could improve cyclosporine loading and solubility...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28392957/boswellic-acid-improves-cognitive-function-in-a-rat-model-through-its-antioxidant-activity-neuroprotective-effect-of-boswellic-acid
#6
Saeedeh Ebrahimpour, Mehdi Fazeli, Soghra Mehri, Mahnaz Taherianfard, Hossein Hosseinzadeh
OBJECTIVES: Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is a pentacyclic terpenoid that is active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and memory impairment, but the mechanism is poorly understood. This study investigated the effects of boswellic acid on spatial learning and memory impairment induced by trimethyltin (TMT) in Wistar rats. METHODS: Forty male Wistar rats were randomly divided into 5 groups: Normal group, TMT-administrated rats (8...
March 2017: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28390130/oral-diseases-a-14-year-experience-of-a-chilean-institution-with-a-systematic-review-from-eight-countries
#7
C Rivera, C Jones-Herrera, P Vargas, B Venegas, D Droguett
BACKGROUND: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce. MATERIAL AND METHODS: This study investigated the frequency of OD in a Chilean population. For this, we included all patients treated at the University of Talca (UTALCA, Chile) between 2001 and 2014...
April 8, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28383562/vps35-regulates-parkin-substrate-aimp2-toxicity-by-facilitating-lysosomal-clearance-of-aimp2
#8
Seung Pil Yun, Hyojung Kim, Sangwoo Ham, Seung-Hwan Kwon, Gum Hwa Lee, Joo-Ho Shin, Sang Hun Lee, Han Seok Ko, Yunjong Lee
Vacuolar protein sorting-associated protein 35 (VPS35) is involved in retrograde transport of proteins from endosomes to trans-Golgi network. Gene mutations in VPS35 are linked to autosomal dominant late-onset Parkinson's disease (PD). Although the identification of VPS35 mutations has provided novel insight about its interactions with several PD-associated genes including leucine-rich repeat kinase 2 (LRRK2) and α-synuclein, little information is available about the molecular mechanisms of cell death downstream of VPS35 dysfunction...
April 6, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28381769/a-review-of-anti-inflammatory-terpenoids-from-the-incense-gum-resins-frankincense-and-myrrh
#9
Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa
Frankincense and myrrh have been used as incense in religious and cultural ceremonies since the beginning of written history. Their common medicinal properties are used in the treatment for inflammatory conditions, some cancerous diseases, and wound healing. In the course of our characterization of the anti-inflammatory constituents from frankincense and myrrh, several terpenoid constituents were found to inhibit nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Here we review the structure of those terpenoid constituents from the gum resins of frankincense and myrrh and evaluate their anti-inflammatory effects by their nitric oxide production inhibitory activity...
April 4, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28368524/the-health-impact-of-adult-cervical-deformity-in-patients-presenting-for-surgical-treatment-comparison-to-united-states-population-norms-and-chronic-disease-states-based-on-the-euroquol-5-dimensions-questionnaire
#10
Justin S Smith, Breton Line, Shay Bess, Christopher I Shaffrey, Han Jo Kim, Gregory Mundis, Justin K Scheer, Eric Klineberg, Michael O'Brien, Richard Hostin, Munish Gupta, Alan Daniels, Michael Kelly, Jeffrey L Gum, Frank J Schwab, Virginie Lafage, Renaud Lafage, Tamir Ailon, Peter Passias, Themistocles Protopsaltis, Todd J Albert, K Daniel Riew, Robert Hart, Doug Burton, Vedat Deviren, Christopher P Ames, International Spine Study Group
BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database...
March 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28366931/hydrocortisone-induced-parkin-prevents-dopaminergic-cell-death-via-creb-pathway-in-parkinson-s-disease-model
#11
Sangwoo Ham, Yun-Il Lee, Minkyung Jo, Hyojung Kim, Hojin Kang, Areum Jo, Gum Hwa Lee, Yun Jeong Mo, Sang Chul Park, Yun Song Lee, Joo-Ho Shin, Yunjong Lee
Dysfunctional parkin due to mutations or post-translational modifications contributes to dopaminergic neurodegeneration in Parkinson's disease (PD). Overexpression of parkin provides protection against cellular stresses and prevents dopamine cell loss in several PD animal models. Here we performed an unbiased high-throughput luciferase screening to identify chemicals that can increase parkin expression. Among promising parkin inducers, hydrocortisone possessed the most favorable profiles including parkin induction ability, cell protection ability, and physicochemical property of absorption, distribution, metabolism, and excretion (ADME) without inducing endoplasmic reticulum stress...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28360899/members-of-the-oral-microbiota-are-associated-with-il-8-release-by-gingival-epithelial-cells-in-healthy-individuals
#12
Katharina Schueller, Alessandra Riva, Stefanie Pfeiffer, David Berry, Veronika Somoza
The triggers for the onset of oral diseases are still poorly understood. The aim of this study was to characterize the oral bacterial community in healthy humans and its association with nutrition, oral hygiene habits, and the release of the inflammatory marker IL-8 from gingival epithelial cells (GECs) with and without stimulation by bacterial endotoxins to identify possible indicator operational taxonomic units (OTUs) associated with inflammatory marker status. GECs from 21 healthy participants (13 females, 8 males) were incubated with or without addition of bacterial lipopolysaccharides (LPSs), and the oral microbiota was profiled using 16S rRNA gene-targeted sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28355984/hydroxychloroquine-induced-hyperpigmentation-in-systemic-diseases-prevalence-clinical-features-and-risk-factors-a-cross-sectional-study-of-41-cases
#13
E Bahloul, M Jallouli, S Garbaa, S Marzouk, A Masmoudi, H Turki, Z Bahloul
Introduction Hydroxychloroquine is an antimalarial agent widely prescribed in internal medicine, rheumatology and dermatology. Its use can be complicated by various side effects including skin pigmentation. Objectives The aim of the study is to review epidemiological, clinical features and risk factors of hydroxychloroquine-induced pigmentation. Materials and methods We performed a cross-sectional study conducted over a period of 5 months. During this period, patients who had been treated with hydroxychloroquine for over 6 months, in the internal medicine department, underwent a complete dermatological examination...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28349984/evidence-for-salicylic-acid-signalling-and-histological-changes-in-the-defence-response-of-eucalyptus-grandis-to-chrysoporthe-austroafricana
#14
Lizahn Zwart, Dave Kenneth Berger, Lucy Novungayo Moleleki, Nicolaas A van der Merwe, Alexander A Myburg, Sanushka Naidoo
Eucalyptus species are cultivated for forestry and are of economic importance. The fungal stem canker pathogen Chrysoporthe austroafricana causes disease of varying severity on E. grandis. The Eucalyptus grandis-Chrysoporthe austroafricana interaction has been established as a model system for studying Eucalyptus antifungal defence. Previous studies revealed that the phytohormone salicylic acid (SA) affects the levels of resistance in highly susceptible (ZG14) and moderately resistant (TAG5) clones. The aims of this study were to examine histochemical changes in response to wounding and inoculation as well as host responses at the protein level...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331623/gum-arabic-as-novel-anti-oxidant-agent-in-sickle-cell-anemia-phase-ii-trial
#15
Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang, Amal M Saeed
BACKGROUND: Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28325340/low-molecular-weight-xanthan-gum-for-treating-osteoarthritis
#16
Guanying Han, Qixin Chen, Fei Liu, Zan Cui, Huarong Shao, Fuyan Liu, Aibin Ma, Joshua Liao, Bin Guo, Yuewei Guo, Fengshan Wang, Peixue Ling, Xifan Mei
Osteoarthritis (OA) is one of the most common chronic diseases and characterized by degradation of articular cartilage. We have previously reported xanthan gum (XG) injection preparation with high molecular weights (Mw) in ranging from 3×10(6)Da to 5×10(6)Da (HM-XG) could enhance the viscosity of synovial fluid, protect joint cartilage in rabbit, and the therapeutical effect has no significance difference with an existing clinical medication (sodium hyaluronate, SH) at the same injection frequency (once weekly for 5 weeks)...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28316794/periodontitis-as-a-possible-early-sign-of-diabetes-mellitus
#17
Wijnand J Teeuw, Madeline X F Kosho, Dennis C W Poland, Victor E A Gerdes, Bruno G Loos
OBJECTIVE: The early diagnosis of (pre)diabetes mellitus is essential for the prevention of diabetes complications. It has been suggested that gum disease (periodontitis) might be an early complication of diabetes and may be a useful risk indicator for diabetes screening. Therefore, a dental office could be a good location for screening for (pre)diabetes in patients with periodontitis using a validated glycated hemoglobin (HbA1c) dry spot analysis. RESEARCH DESIGN AND METHODS: A total of 313 individuals from a university dental clinic participated...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28303470/the-caries-preventive-effect-of-1-year-use-of-low-dose-xylitol-chewing-gum-a-randomized-placebo-controlled-clinical-trial-in-high-caries-risk-adults
#18
Fabio Cocco, Giovanna Carta, Maria Grazia Cagetti, Laura Strohmenger, Peter Lingström, Guglielmo Campus
OBJECTIVES: The caries preventive effect of long-term use (1 year) of low-dosage (2.5 g/die) of xylitol chewing gum in a high-caries-risk adult population was evaluated. MATERIALS AND METHODS: In this randomized clinical trial, 179 high-caries-risk adults were assigned to two experimental groups, xylitol and polyols. Caries status, salivary mutans streptococci (MS), and plaque pH were re-evaluated after 2 years from baseline in 66 xylitol and 64 polyol subjects...
March 16, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28281613/oral-health-what-is-gum-disease
#19
H Ahmed
No abstract text is available yet for this article.
March 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28279958/gum-disease-is-an-early-sign-of-diabetes-and-tooth-loss-is-associated-with-risk-of-dementia-studies-find
#20
Susan Mayor
No abstract text is available yet for this article.
March 8, 2017: BMJ: British Medical Journal
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