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https://www.readbyqxmd.com/read/29223649/novel-liposome-based-and-in-situ-gelling-artificial-tear-formulation-for-dry-eye-disease-treatment
#1
Duygu Acar, Irene Teresa Molina-Martínez, Miguel Gómez-Ballesteros, Manuel Guzmán-Navarro, José Manuel Benítez-Del-Castillo, Rocío Herrero-Vanrell
PURPOSE: Artificial tears are widely used in the treatment of dry eye disease, although current formulations do not closely resemble natural tears. The purpose of this study was the design and characterization of a novel in situ gelling artificial tear formulation, containing both lipid and aqueous components, in order to resemble natural tears and replenish the tear film. METHODS: Liposomes, containing phosphatidylcholine, cholesterol, vitamins A and E, were prepared by the thin-film hydration method...
December 6, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29207824/comparative-evaluation-of-antiplaque-efficacy-of-coconut-oil-pulling-and-a-placebo-among-dental-college-students-a-randomized-controlled-trial
#2
Jithender Nagilla, Suhas Kulkarni, Padma Reddy Madupu, Dolar Doshi, Srikanth Reddy Bandari, Adepu Srilatha
Introduction: Oil pulling, has been extensively used as traditional Indian folk remedy since many years to prevent dental diseases and for strengthening teeth and gums. Aim: To compare and evaluate antiplaque efficacy of coconut oil pulling with a placebo among dental students, in Hyderabad city of India. Materials and Methods: A randomized controlled study was carried out among 40 dental students. Out of 40, 20 subjects were randomly assigned to study group and other 20 to control group...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29202145/the-benefits-of-physician-pharmacist-collaboration
#3
REVIEW
Andrew Y Hwang, Tyler H Gums, John G Gums
Over the past decade, physician-pharmacist collaborative practices have gained traction in primary care as a way to implement team-based-care models. And there is evidence pointing to the effectiveness of this multidisciplinary heath care team approach, in which pharmacists are typically responsible for such things as obtaining medication histories, identifying barriers to adherence, and adjusting medication regimens. Several studies have shown the significant impact that physician-pharmacist collaborative management (PPCM) can have on blood pressure control among patients with hypertension...
December 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/29195760/disparities-in-knowledge-about-the-health-effects-of-smoking-among-adolescents-following-the-release-of-new-pictorial-health-warning-labels
#4
Tara Elton-Marshall, Rochelle Wijesingha, Ryan David Kennedy, David Hammond
This paper examined knowledge about the health effects of smoking among health equity groups following the 2012 introduction of refreshed pictorial health warning labels (HWLs) in Canada. Data are from the 2012/2013 Youth Smoking Survey a representative school-based survey of 47,203 adolescents in Grades 6-12 in nine provinces. Regression models examined overall knowledge about eight health effects of smoking included in the HWLs. Less than one-third of adolescents (32.2%) knew that smoking causes vision loss/blindness and 33...
November 28, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29179363/oral-and-dental-aspects-of-child-abuse-and-neglect
#5
(no author information available yet)
In all 50 states, health care providers (including dentists) are mandated to report suspected cases of abuse and neglect to social service or law enforcement agencies. The purpose of this report is to review the oral and dental aspects of physical and sexual abuse and dental neglect in children and the role of pediatric care providers and dental providers in evaluating such conditions. This report addresses the evaluation of bite marks as well as perioral and intraoral injuries, infections, and diseases that may raise suspicion for child abuse or neglect...
September 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29165844/oral-microbiomes-from-hunter-gatherers-and-traditional-farmers-reveal-shifts-in-commensal-balance-and-pathogen-load-linked-to-diet
#6
Florent Lassalle, Matteo Spagnoletti, Matteo Fumagalli, Liam Shaw, Mark Dyble, Catherine Walker, Mark G Thomas, Andrea Bamberg Migliano, Francois Balloux
Maladaptation to modern diets has been implicated in several chronic disorders. Given the higher prevalence of disease such as dental caries and chronic gum diseases in industrialized societies, we sought to investigate the impact of different subsistence strategies on oral health and physiology, as documented by the oral microbiome. To control for confounding variables such as environment and host genetics, we sampled saliva from three pairs of populations of hunter-gatherers and traditional farmers living in close proximity in the Philippines...
November 22, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29151456/characterization-of-specimens-obtained-by-different-sampling-methods-for-evaluation-of-periodontal-bacteria
#7
Ayako Okada, Kaoru Sogabe, Hiroaki Takeuchi, Masaaki Okamoto, Yoshiaki Nomura, Nobuhiro Hanada
Quantitative analysis of periodontal bacteria is considered useful for clinical diagnosis, evaluation and assessment of the risk of periodontal disease. The purpose of this study was to compare the effectiveness of sampling of saliva, supragingival and subgingival plaque for evaluation of periodontal bacteria. From each of 12 subjects, i) subgingival plaque was collected from the deepest pocket using a sterile paper point, ii) stimulated whole saliva was collected after chewing gum, and iii) supragingival plaque was collected using a tooth brush...
November 17, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29146214/-treatments-of-steroid-dependent-nephrotic-syndrome-in-children
#8
A Couderc, E Bérard, V Guigonis, I Vrillon, J Hogan, V Audard, V Baudouin, C Dossier, O Boyer
Primary nephrotic syndrome (NS) is the most common glomerular disease in children. It is characterized by massive proteinuria and hypoalbuminemia. It typically has a sudden onset and more than 70% of patients will experience at least one relapse. An immunological origin has long been postulated, although the precise molecular mechanisms underlying the disease remain debated. Steroids are the first-line therapy with cumulative dose and duration of initial treatment varying among countries. Steroid-sparing agents may be indicated in case of steroid-dependency or frequent relapses...
November 13, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29122066/oral-and-dental-aspects-of-child-abuse-and-neglect
#9
Susan A Fisher-Owens, James L Lukefahr, Anupama Rao Tate
In all 50 states, health care providers (including dentists) are mandated to report suspected cases of abuse and neglect to social service or law enforcement agencies. The purpose of this report is to review the oral and dental aspects of physical and sexual abuse and dental neglect in children and the role of pediatric care providers and dental providers in evaluating such conditions. This report addresses the evaluation of bite marks as well as perioral and intraoral injuries, infections, and diseases that may raise suspicion for child abuse or neglect...
July 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29114946/reported-gum-disease-as-a-cardiovascular-risk-factor-in-adults-with-intellectual-disabilities
#10
K Hsieh, S Murthy, T Heller, J H Rimmer, G Yen
BACKGROUND: Several risk factors for cardiovascular disease (CVD) have been identified among adults with intellectual disabilities (ID). Periodontitis has been reported to increase the risk of developing a CVD in the general population. Given that individuals with ID have been reported to have a higher prevalence of poor oral health than the general population, the purpose of this study was to determine whether adults with ID with informant reported gum disease present greater reported CVD than those who do not have reported gum disease and whether gum disease can be considered a risk factor for CVD...
November 8, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29112341/the-interaction-effects-between-race-and-functional-disabilities-on-the-prevalence-of-self-reported-periodontal-diseases-national-health-and-nutrition-examination-survey-2011-2012
#11
R Suzuki
BACKGROUND: Racial minority groups and adults with functional disabilities (FDs) disproportionally experience periodontal diseases. However, little is known about the interactions of these two characteristics in disease prevalence. The purpose of this study was to examine the association between FDs and periodontal experiences, and to identify whether race has a particular influence on this relationship. METHODS: Data were derived from the National Health and Nutrition Examination Survey 2011-2012, in a representative sample of adults aged 30 years and older...
November 10, 2017: Community Dental Health
https://www.readbyqxmd.com/read/29107683/hypoxia-regulates-the-level-of-glutamic-acid-decarboxylase-enzymes-and-interrupts-inhibitory-synapse-stability-in-primary-cultured-neurons
#12
Seojin Hwang, Sangwoo Ham, Seong-Eun Lee, Yunjong Lee, Gum Hwa Lee
Gamma-aminobutyric acid (GABA) is the main neurotransmitter of inhibitory synaptic transmission, which is critical for oscillatory activity and synchronization of neurons in neural networks. GABA is synthesized by glutamic acid decarboxylase (GAD) enzymes in the inhibitory neuron and, thus, the deregulation of GAD enzymes and subsequent change of GABAergic activity are involved in various neurological and neuropsychiatric diseases. Under hypoxic conditions, neurons undergo neuropathological alterations which can be subtle or severe...
October 28, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/29081672/prevalence-and-factors-associated-with-dental-erosion-in-individuals-aged-12-30-years-in-a-northeastern-brazilian-city
#13
Luanda Cristina O Luciano, Meire Coelho Ferreira, Marco Aurelio Paschoal
BACKGROUND/PURPOSE: Dental erosion in young individuals has increased significantly in recent years, due to changes in lifestyle. Thus, the present study investigated the prevalence and factors associated with dental erosion in individuals aged 12-30 years in the city of Imperatriz of Maranhão, Brazil. MATERIALS AND METHODS: A cross-sectional study was conducted on 335 individuals who answered a questionnaire consisting of variables related to dental erosion. Afterwards, the individuals were subjected to clinical examinations and the basic erosive wear examination index was used to classify their teeth according to the presence and severity of dental erosion...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/29059464/fluoride-supplementation-with-tablets-drops-lozenges-or-chewing-gum-in-pregnant-women-for-preventing-dental-caries-in-the-primary-teeth-of-their-children
#14
REVIEW
Rena Takahashi, Erika Ota, Keika Hoshi, Toru Naito, Yoshihiro Toyoshima, Hidemichi Yuasa, Rintaro Mori, Eishu Nango
BACKGROUND: Dental caries (tooth decay) is one of the most common chronic childhood diseases. Caries prevalence in most industrialised countries has declined among children over the past few decades. The probable reasons for the decline are the widespread use of fluoride toothpaste, followed by artificial water fluoridation, oral health education and a slight decrease in sugar consumption overall. However, in regions without water fluoridation, fluoride supplementation for pregnant women may be an effective way to increase fluoride intake during pregnancy...
October 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29033912/the-infectious-basis-of-acpa-positive-rheumatoid-arthritis
#15
REVIEW
Lazaros I Sakkas, Dimitrios Daoussis, Stamatis-Nick Liossis, Dimitrios P Bogdanos
Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers in RA, namely Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans causes of periodontal disease (PD), and Epstein-Barr virus (EBV). P. gingivalis expresses arginine gingipains, that cleave proteins at the arginine residues, and peptidyl arginine deiminase (PPAD), which citrullinates arginine residues of proteins, thus forming neoantigens that lead to ACPA production...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29031949/evaluation-of-irimedadi-taila-as-an-adjunctive-in-treating-plaque-induced-gingivitis
#16
Shweta Patil, Siddhartha A Varma, Girish Suragimath, Keshava Abbayya, Sameer A Zope, Vishwajeet Kale
BACKGROUND: Ayurvedic drugs have been used since ancient times to treat diseases including periodontal diseases. Oral rinses made from ayurvedic medicines are used in periodontal therapy to control bleeding and reduce inflammation. OBJECTIVE: To evaluate the efficacy of herbal preparation (Irimedadi taila) on reduction of plaque induced gingivitis. MATERIALS AND METHODS: A total of 100 volunteers with clinical signs of mild to moderate gingivitis were selected and assigned to Group A (only scaling done) and Group B (scaling along with the use of Irimedadi taila)...
October 11, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29026519/squamous-cell-carcinoma-arising-in-familial-gingival-fibromatosis-a-rare-case-report
#17
Dilasma Ghartimagar, Ujjwal Koirala, Arnab Ghosh, Manish Kiran Shrestha, Sushma Thapa, Raghavan Narasimhan, O P Talwar
Familial gingival fibromatosis is a rare hereditary condition due to chromosomal abnormality which can occur as an isolated disease or as part of a syndrome and has an incidence of 1:350 000. This condition leads to esthetic, functional, psychological and masticatory disturbance of the oral cavity. Here, we present a case of 21-year-old female with severe enlargement of gums in maxilla and mandible. Deciduous teeth were erupted at normal age but the permanent teeth in the oral cavity were not erupted. Her grandmother, father and younger sister were also affected with the same condition...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28972555/crispr-cas9-mediated-telomere-removal-leads-to-mitochondrial-stress-and-protein-aggregation
#18
Hyojung Kim, Sangwoo Ham, Minkyung Jo, Gum Hwa Lee, Yun-Song Lee, Joo-Ho Shin, Yunjong Lee
Aging is considered the major risk factor for neurodegenerative diseases including Parkinson's disease (PD). Telomere shortening is associated with cellular senescence. In this regard, pharmacological or genetic inhibition of telomerase activity has been used to model cellular aging. Here, we employed CRISPR-Cas9 technology to instantly remove the telomere to induce aging in a neuroblastoma cell line. Expression of both Cas9 and guide RNA targeting telomere repeats ablated the telomere, leading to retardation of cell proliferation...
October 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28968558/associations-between-oral-hygiene-habits-diet-tobacco-and-alcohol-and-risk-of-oral-cancer-a-case-control-study-from-india
#19
Bhawna Gupta, Freddie Bray, Narinder Kumar, Newell W Johnson
OBJECTIVE: This study examines the association between the incidence of oral cancer in India and oral hygiene habits, diet, chewing and smoking tobacco, and drinking alcohol. We also assessed the effects of oral hygiene habits with oral cancer risk among chewers versus never chewers. METHODS: A hospital-based case-control study was conducted in Pune, India, based on face-to-face interviews, anthropometry, and intra-oral examinations conducted for 187 oral cancer cases and 240 controls...
September 29, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28919445/cognitive-effects-of-labeled-addictolytic-medications
#20
REVIEW
Camille Noélie Pujol, Cecilia Paasche, Vincent Laprevote, Benoit Trojak, Pierre Vidailhet, Elisabeth Bacon, Laurence Lalanne
INTRODUCTION: Alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and abuse of these substances is a major contributor to the global disease burden. Many pharmacotherapies have been developed over the last 50years to target addictive disorders. While the efficacy of these pharmacotherapies is largely recognized, their cognitive impact is less known. However, all substance abuse disorders are known to promote cognitive disorders like executive dysfunction and memory impairment...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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