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https://www.readbyqxmd.com/read/28533304/modulation-of-the-gut-microbiota-impacts-non-alcoholic-fatty-liver-disease-a-potential-role-for-bile-acids
#1
Aafke Wf Janssen, Tom Houben, Saeed Katiraei, Wieneke Dijk, Lily Boutens, Nieke van der Bolt, Zeneng Wang, J Mark Brown, Stanley L Hazen, Stéphane Mandard, Ronit Shiri-Sverdlov, Folkert Kuipers, Ko Willems van Dijk, Jacques Vervoort, Rinke Stienstra, Guido Jej Hooiveld, Sander Kersten
Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding mice the fermentable dietary fiber guar gum and suppressing the gut bacteria via chronic oral administration of antibiotics. Guar gum feeding profoundly altered the gut microbiota composition, in parallel with reduced diet-induced obesity and improved glucose tolerance...
May 22, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28512604/traditional-dentistry-knowledge-among-serbs-in-several-balkan-countries
#2
Dragan V Ilic, Biljana Andjelski Radicevic, Anely Nedelcheva, Ivana Djurovic, Dejan Ostojic
BACKGROUND/AIM: There are still unrevealed treasures of traditional dental medicine, that is, the reason to investigate and present various ways in treatment of oral and orofacial tissues, as well as magic and religious elements involved in representative areas among Serbs. MATERIALS AND METHODS: Information was collected from the elderly non-professional folk dentists and herbalists with the additional help of local physicians and dentists that was done through questionnaire and personal interviews...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28503128/a-confounding-case-of-inherited-factor-v-deficiency-complicated-by-inhibitors-at-first-presentation
#3
Hema Subramanian, Rakhee Kar, Deepak Charles, Hitha Babu, Pagadalu Ambika, Tarun Kumar Dutta
INTRODUCTION: Inherited factor V deficiency / Owren's disease has varied clinical manifestations ranging from asymptomatic laboratory abnormalities to massive hemorrhage. The acquired form due to inhibitors following antibiotic therapy, infection, or surgery is less common, and spontaneous development of inhibitors is not known. CASE REPORT: An 18-year-old boy presented with bleeding axillary and groin ulcers. At the age of 15, due to recurrent epistaxis and gum bleed, he was diagnosed with acquired factor V deficiency with positive inhibitor screen and treated with fresh frozen plasma (FFP) transfusion and temporary azathioprine...
April 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28494594/caring-for-baby-s-teeth-starts-before-birth
#4
L Paglia
Care for a child's teeth and gums can start even before the baby is born. Pregnancy causes many hormonal changes, among these the rise of estrogen and progesterone increases the risk of developing oral health problems, like gingivitis and periodontitis.The presence of maternal periodontal diseases and active infections has been associated with adverse pregnancy outcomes, such as preterm birth, preeclampsia, gestational diabetes and foetal loss. Therefore, it is important to educate pregnant women about their oral hygiene and the importance of taking care of their newborn's oral health...
March 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28476775/defining-genetic-fitness-determinants-and-creating-genomic-resources-for-an-oral-pathogen
#5
Ajay M Narayanan, Matthew M Ramsey, Apollo Stacy, Marvin Whiteley
Periodontitis is a microbial infection that destroys the structures that support the teeth. Although typically a chronic condition, rapidly progressing, aggressive forms are associated with the oral pathogen Aggregatibacter actinomycetemcomitans One of this bacterium's key virulence traits is its ability to attach to surfaces and form robust biofilms that resist killing by the host and antibiotics. Though much has been learned about A. actinomycetemcomitans since its initial discovery, we lack insight into a fundamental aspect of its basic biology, as we do not know the full set of genes that it requires for viability (essential genome)...
May 5, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28467839/preparation-of-hollow-biopolymer-nanospheres-employing-starch-nanoparticle-templates-for-enhancement-of-phenolic-acid-antioxidant-activities
#6
Xiaojing Li, Man Li, Jing Liu, Na Ji, Caifeng Liang, Qingjie Sun, Liu Xiong
Phenolic acids have been extensively studied because of their bioactive properties and disease prevention and control capacities. However, undesired odors and taste, low aqueous solubility, and thermal and ultraviolet (UV) light instability severely restrict their application. The aim of this work was to evaluate the enhancement in antioxidative activities of phenolic acids in hollow nanospheres and their stability in terms of their antioxidative activities under harsh conditions. For the first time, we have successfully fabricated hollow short linear glucan (SLG)@gum arabic (GA) nanospheres and hollow in situ SLG/GA hybrid nanospheres by removing the sacrificial starch nanoparticle templates through α-amylase treatment and Ostwald ripening...
May 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28458930/an-18-month-old-child-with-infantile-pompe-disease-oral-signs
#7
Derya Ceyhan, Burcu Gucyetmez Topal
We aim to create an information platform by contributing orodental findings of Pompe disease to literature. An 18-month-old male patient with Pompe disease was referred to our clinic due to swelling of the gums. In first dental examination, a nonfluctuant, normal gingiva colored swelling at the right anterior region of maxilla was detected. His parents were recommended to perform finger massage to the region. Six months later, 51, 52, 62, and 74 numbered teeth had erupted, there was a fusion between 51 and 52 numbered teeth, 84 numbered tooth was seen to be erupted, and a swelling at the site of this tooth, similar to previous one, was present...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28441306/orientation-of-the-upper-most-instrumented-segment-influences-proximal-junctional-disease-following-adult-spinal-deformity-surgery
#8
Renaud Lafage, Breton G Line, Sachin Gupta, Barthelemy Liabaud, Frank Schwab, Justin S Smith, Jeffrey L Gum, Christopher P Ames, Richard Hostin, Gregory M Mundis, Han Jo Kim, Shay Bess, Eric Klineberg, Virginie Lafage
STUDY DESIGN: Retrospective review of a prospective database. OBJECTIVE: To define the role of sagittal orientation of the construct at the upper instrumented levels in the development of proximal junctional kyphosis (PJK) in adult spinal deformity (ASD) patients. SUMMARY OF BACKGROUND DATA: PJK following ASD surgery remains challenging. The final alignment of the upper instrumented vertebral segments has been proposed as a risk factor for PJK, but has not been fully investigated...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28425301/development-of-a-novel-rationally-designed-antibiotic-to-inhibit-a-nontraditional-bacterial-target
#9
Pavel Dibrov, Elena Dibrov, Thane G Maddaford, Melissa Kenneth, Jordan Nelson, Craig Resch, Grant N Pierce
The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na(+)-translocating NADH:ubiquinone oxidoreductase (Na(+)-NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process. Infection by Chlamydia trachomatis significantly increased first H(+) and then Na(+) levels within the host mammalian cell...
May 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28424689/antimicrobial-and-attractant-roles-for-chemerin-in-the-oral-cavity-during-inflammatory-gum-disease
#10
Urszula Godlewska, Piotr Brzoza, Aneta Sroka, Pawel Majewski, Holger Jentsch, Martin Eckert, Sigrun Eick, Jan Potempa, Brian A Zabel, Joanna Cichy
Periodontal inflammation is one of the most common chronic inflammatory conditions in humans. Despite recent advances in identifying and characterizing oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors maintain a healthy homeostatic oral microbial community or prevent the development of a pathogenic oral microbiota remains poorly understood. An important determinant of microbiota fate is local antimicrobial proteins. Here, we report that chemoattractant protein chemerin, which we recently identified as a potent endogenous antimicrobial agent in body barriers such as the skin, is present in the oral cavity under homeostatic and inflammatory conditions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28406130/is-the-periodontal-status-a-risk-factor-for-the-development-of-psoriasis
#11
G Sarac, Y Kapicioglu, S Cayli, A Altas, S Yologlu
BACKGROUND AND OBJECTIVES: Psoriasis is a common, chronic, inflammatory, and hyperproliperative skin disease. It has been known that the infectious agents play a role in triggering and exacerbation of the disease. Periodontal diseases are chronic inflammatory gum diseases initiated by microorganisms in dental plaques. This study intended to determine the role of periodontal diseases, as chronic infective foci in psoriasis. MATERIALS AND METHODS: A total of 76 patients, who applied to Faculty of Medicine, Department of Dermatology, İnönü University, diagnosed as psoriasis and a control group consisting of 76 dermatologic patients without any systemic disease at similar age and gender were included the study...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28405165/enhancement-of-physicochemical-properties-of-nanocolloidal-carrier-loaded-with-cyclosporine-for-topical-treatment-of-psoriasis-in-vitro-diffusion-and-in-vivo-hydrating-action
#12
Siti Hajar Musa, Mahiran Basri, Hamid Reza Fard Masoumi, Norashikin Shamsudin, Norazlinaliza Salim
Psoriasis is a chronic autoimmune disease that cannot be cured. It can however be controlled by various forms of treatment, including topical, systemic agents, and phototherapy. Topical treatment is the first-line treatment and favored by most physicians, as this form of therapy has more patient compliance. Introducing a nanoemulsion for transporting cyclosporine as an anti-inflammatory drug to an itchy site of skin disease would enhance the effectiveness of topical treatment for psoriasis. The addition of nutmeg and virgin coconut-oil mixture, with their unique properties, could improve cyclosporine loading and solubility...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28392957/boswellic-acid-improves-cognitive-function-in-a-rat-model-through-its-antioxidant-activity-neuroprotective-effect-of-boswellic-acid
#13
Saeedeh Ebrahimpour, Mehdi Fazeli, Soghra Mehri, Mahnaz Taherianfard, Hossein Hosseinzadeh
OBJECTIVES: Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is a pentacyclic terpenoid that is active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and memory impairment, but the mechanism is poorly understood. This study investigated the effects of boswellic acid on spatial learning and memory impairment induced by trimethyltin (TMT) in Wistar rats. METHODS: Forty male Wistar rats were randomly divided into 5 groups: Normal group, TMT-administrated rats (8...
March 2017: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28390130/oral-diseases-a-14-year-experience-of-a-chilean-institution-with-a-systematic-review-from-eight-countries
#14
C Rivera, C Jones-Herrera, P Vargas, B Venegas, D Droguett
BACKGROUND: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce. MATERIAL AND METHODS: This study investigated the frequency of OD in a Chilean population. For this, we included all patients treated at the University of Talca (UTALCA, Chile) between 2001 and 2014...
May 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28383562/vps35-regulates-parkin-substrate-aimp2-toxicity-by-facilitating-lysosomal-clearance-of-aimp2
#15
Seung Pil Yun, Hyojung Kim, Sangwoo Ham, Seung-Hwan Kwon, Gum Hwa Lee, Joo-Ho Shin, Sang Hun Lee, Han Seok Ko, Yunjong Lee
Vacuolar protein sorting-associated protein 35 (VPS35) is involved in retrograde transport of proteins from endosomes to trans-Golgi network. Gene mutations in VPS35 are linked to autosomal dominant late-onset Parkinson's disease (PD). Although the identification of VPS35 mutations has provided novel insight about its interactions with several PD-associated genes including leucine-rich repeat kinase 2 (LRRK2) and α-synuclein, little information is available about the molecular mechanisms of cell death downstream of VPS35 dysfunction...
April 6, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28381769/a-review-of-anti-inflammatory-terpenoids-from-the-incense-gum-resins-frankincense-and-myrrh
#16
Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa
Frankincense and myrrh have been used as incense in religious and cultural ceremonies since the beginning of written history. Their common medicinal properties are used in the treatment for inflammatory conditions, some cancerous diseases, and wound healing. In the course of our characterization of the anti-inflammatory constituents from frankincense and myrrh, several terpenoid constituents were found to inhibit nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Here we review the structure of those terpenoid constituents from the gum resins of frankincense and myrrh and evaluate their anti-inflammatory effects by their nitric oxide production inhibitory activity...
April 4, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28368524/the-health-impact-of-adult-cervical-deformity-in-patients-presenting-for-surgical-treatment-comparison-to-united-states-population-norms-and-chronic-disease-states-based-on-the-euroquol-5-dimensions-questionnaire
#17
Justin S Smith, Breton Line, Shay Bess, Christopher I Shaffrey, Han Jo Kim, Gregory Mundis, Justin K Scheer, Eric Klineberg, Michael O'Brien, Richard Hostin, Munish Gupta, Alan Daniels, Michael Kelly, Jeffrey L Gum, Frank J Schwab, Virginie Lafage, Renaud Lafage, Tamir Ailon, Peter Passias, Themistocles Protopsaltis, Todd J Albert, K Daniel Riew, Robert Hart, Doug Burton, Vedat Deviren, Christopher P Ames, International Spine Study Group
BACKGROUND: Although adult cervical spine deformity (ACSD) is associated with pain and disability, its health impact has not been quantified in comparison to other chronic diseases. OBJECTIVE: To perform a comparative analysis of the health impact of symptomatic ACSD to US normative and chronic disease values using EQ-5D (EuroQuol-5 Dimensions questionnaire) scores. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database...
March 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28366931/hydrocortisone-induced-parkin-prevents-dopaminergic-cell-death-via-creb-pathway-in-parkinson-s-disease-model
#18
Sangwoo Ham, Yun-Il Lee, Minkyung Jo, Hyojung Kim, Hojin Kang, Areum Jo, Gum Hwa Lee, Yun Jeong Mo, Sang Chul Park, Yun Song Lee, Joo-Ho Shin, Yunjong Lee
Dysfunctional parkin due to mutations or post-translational modifications contributes to dopaminergic neurodegeneration in Parkinson's disease (PD). Overexpression of parkin provides protection against cellular stresses and prevents dopamine cell loss in several PD animal models. Here we performed an unbiased high-throughput luciferase screening to identify chemicals that can increase parkin expression. Among promising parkin inducers, hydrocortisone possessed the most favorable profiles including parkin induction ability, cell protection ability, and physicochemical property of absorption, distribution, metabolism, and excretion (ADME) without inducing endoplasmic reticulum stress...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28360899/members-of-the-oral-microbiota-are-associated-with-il-8-release-by-gingival-epithelial-cells-in-healthy-individuals
#19
Katharina Schueller, Alessandra Riva, Stefanie Pfeiffer, David Berry, Veronika Somoza
The triggers for the onset of oral diseases are still poorly understood. The aim of this study was to characterize the oral bacterial community in healthy humans and its association with nutrition, oral hygiene habits, and the release of the inflammatory marker IL-8 from gingival epithelial cells (GECs) with and without stimulation by bacterial endotoxins to identify possible indicator operational taxonomic units (OTUs) associated with inflammatory marker status. GECs from 21 healthy participants (13 females, 8 males) were incubated with or without addition of bacterial lipopolysaccharides (LPSs), and the oral microbiota was profiled using 16S rRNA gene-targeted sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28355984/hydroxychloroquine-induced-hyperpigmentation-in-systemic-diseases-prevalence-clinical-features-and-risk-factors-a-cross-sectional-study-of-41-cases
#20
E Bahloul, M Jallouli, S Garbaa, S Marzouk, A Masmoudi, H Turki, Z Bahloul
Introduction Hydroxychloroquine is an antimalarial agent widely prescribed in internal medicine, rheumatology and dermatology. Its use can be complicated by various side effects including skin pigmentation. Objectives The aim of the study is to review epidemiological, clinical features and risk factors of hydroxychloroquine-induced pigmentation. Materials and methods We performed a cross-sectional study conducted over a period of 5 months. During this period, patients who had been treated with hydroxychloroquine for over 6 months, in the internal medicine department, underwent a complete dermatological examination...
January 1, 2017: Lupus
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