keyword
https://read.qxmd.com/read/38479369/increased-severity-of-presentation-signs-in-children-with-newly-diagnosed-type-1-diabetes-during-the-covid-19-pandemic-a-tertiary-center-experience
#21
JOURNAL ARTICLE
Elif İzci Güllü, Leyla Akin, Mehmet Enes Gökler, Murat Aydin
INTRODUCTION: Diabetic ketoacidosis (DKA) is an important complication of Type 1 Diabetes Mellitus (T1DM) which is worsened when the diagnosis of T1DM is delayed. The aim of this study was to evaluate the presentation patterns, severity, autoantibody status and seasonal variability of newly diagnosed T1DM patients during the pandemic period of two years compared to those in the pre-pandemic period. METHODS: In this single tertiary center retrospective cohort study newly diagnosed T1DM patients were grouped as pre-pandemic and pandemic period...
March 13, 2024: Annals of Nutrition & Metabolism
https://read.qxmd.com/read/38476627/a-three-year-cross-sectional-analysis-of-depression-anxiety-and-quality-of-life-in-patients-with-post-covid-19-syndrome
#22
JOURNAL ARTICLE
Adrian Vasile Bota, Iulia Bogdan, David Vladut Razvan, Adrian Cosmin Ilie, Raluca Tudor, Mirela Florica Indries, Andrei Nicolae Csep, Iosif Marincu
BACKGROUND: This study explores the longitudinal psychosocial impact of Long-COVID syndrome, also known as Post-COVID-19 syndrome, characterized by enduring symptoms after coronavirus disease (COVID-19) infection, over the years 2020, 2021, and 2022. It aimed to examine the variations in depression, anxiety, and quality of life among Post-COVID-19 patients during these years, hypothesizing significant inter-year differences reflecting the pandemic's evolving influence. METHODS: Conducted at Victor Babes Hospital for Infectious Diseases and Pulmonology, Romania, this cross-sectional research involved 324 patients diagnosed with mild to moderate COVID-19, assessed six months post-hospitalization...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38470940/the-epidemiological-and-economic-burden-of-diabetes-in-ghana-a-scoping-review-to-inform-health-technology-assessment
#23
JOURNAL ARTICLE
Joseph Kazibwe, Mohamed Gad, Emmanuella Abassah-Konadu, Ivy Amankwah, Richmond Owusu, Godwin Gulbi, Sergio Torres-Rueda, Brian Asare, Anna Vassall, Francis Ruiz
Diabetes remains one of the four major causes of morbidity and mortality globally among non-communicable diseases (NCDs. It is predicted to increase in sub-Saharan Africa by over 50% by 2045. The aim of this study is to identify, map and estimate the burden of diabetes in Ghana, which is essential for optimising NCD country policy and understanding existing knowledge gaps to guide future research in this area. We followed the Arksey and O'Malley framework for scoping reviews. We searched electronic databases including Medline, Embase, Web of Science, Scopus, Cochrane and African Index Medicus following a systematic search strategy...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38468507/validation-of-the-distress-thermometer-as-a-screening-tool-for-psychosocial-distress-and-resilience-in-parkinson-s-disease
#24
JOURNAL ARTICLE
Nils Schnalke, Esther Tekampe, Tim Feige, Anika Frank, Heinz Reichmann, Björn Falkenburger, Simone D'Souza
BACKGROUND: Parkinson's disease (PD) is associated with psychosocial distress that affects patients' quality of life. The distress thermometer (DT) is an 11-point visual analogue scale that is used as a screening tool for the assessment of psychosocial distress, originally developed for oncological diseases. OBJECTIVES: To validate the DT for PD and to explore contributing factors. METHODS: The DT scale was administered to 105 people with Parkinson's Disease (PwPD)...
March 2024: Movement Disorders Clinical Practice
https://read.qxmd.com/read/38468204/the-role-of-subjective-interpersonal-and-structural-social-isolation-in-12-month-and-lifetime-anxiety-disorders
#25
JOURNAL ARTICLE
Ann W Nguyen, Harry Owen Taylor, Robert Joseph Taylor, Alexis Z Ambroise, Tyrone Hamler, Weidi Qin, Linda M Chatters
BACKGROUND: Anxiety disorders are among the most prevalent psychiatric conditions worldwide, and the incidence of anxiety disorders among adults in the U.S. have increased over the last decade. Anxiety disorders can have debilitating effects on multiple areas of functioning and quality of life. Recently, social isolation has emerged as an important public health problem associated with worse health and well-being outcomes. Research on the connection between social isolation and mental health has found that multiple dimensions of social isolation may negatively impact mental health, but few inquiries have focused on the association between social isolation and anxiety...
March 11, 2024: BMC Public Health
https://read.qxmd.com/read/38463987/lower-perceived-social-support-is-significantly-associated-with-elevated-levels-of-psychological-distress-in-racially-and-ethnically-diverse-close-family-members-of-cardiac-arrest-survivors
#26
Mina Yuan, Isabella M Tincher, Bhanvi Sachdeva, Sabine Abukhadra, Danielle A Rojas, Christine DeForge, Sachin Agarwal
BACKGROUND: Poor perceived social support has been associated with worse psychological distress in close family members after their loved one's hospitalization with prolonged mechanical ventilation, but never been tested after cardiac arrest. METHODS: Close family members of consecutive cardiac arrest patients hospitalized at an academic tertiary care center were recruited before hospital discharge, and perceived social support was assessed using the Multidimensional Scale of Perceived Social Support (MSPSS)...
February 27, 2024: medRxiv
https://read.qxmd.com/read/38463157/sleep-quality-quality-of-life-fatigue-and-mental-health-in-covid-19-post-pandemic-t%C3%A3-rkiye-a-cross-sectional-study
#27
JOURNAL ARTICLE
Abdulbari Bener, Ebru Morgul, Mahmut Tokaç, Antonio Ventriglio, Timothy R Jordan
AIM: This study explores the predictors and associated risk factors of sleep quality, quality of life, fatigue, and mental health among the Turkish population during the COVID-19 post-pandemic period. MATERIALS AND METHODS: A cross-sectional survey using multi-stage, stratified random sampling was employed. In total, 3,200 persons were approached. Of these, 2,624 (82%) completed the questionnaire package consisting of socio-demographic information, Pittsburgh Sleep Quality Index (PSQI), the WHO Quality of Life Brief Version (WHOQOL-BREF), Fatigue Assessment Scale (FAS), Patients Health Questionnaire (PHQ-15), GAD-7 anxiety scale, and the 21-item Depression, Anxiety, Stress Scale (DASS-21)...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38462787/pudendal-nerve-blockade-for-persistent-genital-arousal-disorder-pgad-a-clinical-review-and-case-report
#28
Michael J Gyorfi, Alaa Abd-Elsayed
BACKGROUND: Persistent genital arousal disorder (PGAD) is a condition characterized by unwanted and potentially painful genital sensations or spontaneous orgasms without stimulation. We present a case of a 55-year-old woman with refractory genital arousal disorder that was treated with serial pudendal nerve blocks. CASE: RW is a 55-year-old woman with chronic pelvic pain, pudendal neuralgia, MDD, SI, GAD, CRPS, and persistent genital arousal disorder for 11 years...
March 10, 2024: Pain Practice: the Official Journal of World Institute of Pain
https://read.qxmd.com/read/38462045/prevention-of-mk-801-induced-amnestic-effect-with-combined-activation-of-5-ht-1a-and-muscarinic-receptors-in-mice
#29
JOURNAL ARTICLE
Paulina Cieślik, Anna Rafało-Ulińska, Joanna M Wierońska
BACKGROUND: Muscarinic or 5-HT1A receptors are crucial in learning and memory processes, and their expression is evident in the brain areas involved in cognition. The administration of the activators of these receptors prevents the development of cognitive dysfunctions in animal models of schizophrenia induced by MK-801 (N-methyl-d-aspartate receptor antagonist) administration. GABAergic dysfunction is considered as one of the most important causes of MK-801-induced spatial learning deficits...
March 8, 2024: Pharmacology, Biochemistry, and Behavior
https://read.qxmd.com/read/38461564/prevalence-and-factors-associated-with-depression-and-anxiety-among-young-school-going-adolescents-in-the-western-cape-province-of-south-africa
#30
JOURNAL ARTICLE
Mirriam Mkhize, Claire van der Westhuizen, Katherine Sorsdahl
INTRODUCTION: Between 10 and 20% of children and adolescents globally experience common mental health conditions such as depression or anxiety. Given the dearth of mental health services in low- and middle-income countries, most mental health conditions among adolescents remain undiagnosed and untreated. In South Africa, few studies have explored the prevalence of depression and anxiety among young adolescents aged 10-14 years. This study examined the prevalence of, and factors associated with depression and anxiety among young school-going adolescents in the Western Cape Province of South Africa...
March 7, 2024: Comprehensive Psychiatry
https://read.qxmd.com/read/38461278/case-report-glycaemic-management-and-pregnancy-outcomes-in-a-woman-with-an-insulin-receptor-mutation-p-met1180lys
#31
JOURNAL ARTICLE
Mairéad T Crowley, Eirena Goulden, Begona Sanchez-Lechuga, Aileen Fleming, Maria Kennelly, Ciara McDonnell, Maria M Byrne
BACKGROUND: Heterozygous insulin receptor mutations (INSR) are associated with insulin resistance, hyperglycaemia and hyperinsulinaemic hypoglycaemia in addition to hyperandrogenism and oligomenorrhoea in women. Numerous autosomal dominant heterozygous mutations involving the INSR β-subunit tyrosine kinase domain resulting in type A insulin resistance have been previously described. We describe the phenotype, obstetric management and neonatal outcomes in a woman with type A insulin resistance caused by a mutation in the β-subunit of the INSR...
March 10, 2024: Clinical Diabetes and Endocrinology
https://read.qxmd.com/read/38460086/psychological-distress-vaccine-and-booster-acceptance-in-women-considering-or-undergoing-fertility-treatments-during-the-omicron-surge-of-the-covid-19-pandemic
#32
JOURNAL ARTICLE
Luce A Kassi, Angela K Lawson, Eve C Feinberg, Amelia Swanson, Shriya Shah, Mary Ellen Pavone
OBJECTIVE: Follow-up study to evaluate perceptions of COVID-19 vaccination and booster with psychological distress during the COVID-19 pandemic and Omicron surge in women considering or undergoing fertility treatment. MATERIALS AND METHODS: Cross-sectional anonymous survey (N = 2558) from a single academic fertility center. Five hundred forty patients completed the survey (response rate = 21.1%). Participants were randomized 1:1 to a one-page evidence-based graphic with information and benefits regarding COVID-19 vaccination...
March 9, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38459064/high-gain-antipodal-meander-line-antenna-for-point-to-point-wlan-wimax-applications
#33
JOURNAL ARTICLE
Mohamed M Gad, Mai O Sallam
This paper introduces a planar antipodal meander line antenna fabricated using RO3003 substrate. The proposed antenna is designed to radiate in the end-fire direction, achieving a maximum measured gain of 10.43 dBi within its working bandwidth, which ranges from 2.24 GHz to 2.7 GHz, covering long-range WLAN/WiMAX applications. A systematic procedure is adopted in the design process to prove its tunability to cover other application requirements in terms of gain and bandwidth. The proposed design steps show that the bandwidth and the gain can independently be controlled by adjusting specific design parameters such as the number of radiators and the scaling factor...
March 8, 2024: Scientific Reports
https://read.qxmd.com/read/38454373/associations-between-anxiety-depression-and-personal-mastery-in-community-dwelling-older-adults-a-network-based-analysis
#34
JOURNAL ARTICLE
Zekun Bian, Renyan Xu, Bin Shang, Fei Lv, Weiyi Sun, Qian Li, Yijing Gong, Caifeng Luo
BACKGROUND: In China, about 18.70% of the population aged 60 years and older are at risk of low personal mastery as well as anxiety and depression for a variety of reasons. The purpose of this study was to construct a symptom network model of the relationship between anxiety, depression, and personal mastery in community-dwelling older adults and to identify central and bridge symptoms in this network. METHODS: Depression, anxiety, and personal mastery were measured using the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), and Personal Mastery Scale (PMS), respectively...
March 7, 2024: BMC Psychiatry
https://read.qxmd.com/read/38453481/a-maternal-effect-padi6-variant-causes-nuclear-and-cytoplasmic-abnormalities-in-oocytes-as-well-as-failure-of-epigenetic-reprogramming-and-zygotic-genome-activation-in-embryos
#35
JOURNAL ARTICLE
Carlo Giaccari, Francesco Cecere, Lucia Argenziano, Angela Pagano, Antonio Galvao, Dario Acampora, Gianna Rossi, Bruno Hay Mele, Basilia Acurzio, Scott Coonrod, Maria Vittoria Cubellis, Flavia Cerrato, Simon Andrews, Sandra Cecconi, Gavin Kelsey, Andrea Riccio
Maternal inactivation of genes encoding components of the subcortical maternal complex (SCMC) and its associated member, PADI6, generally results in early embryo lethality. In humans, SCMC gene variants were found in the healthy mothers of children affected by multilocus imprinting disturbances (MLID). However, how the SCMC controls the DNA methylation required to regulate imprinting remains poorly defined. We generated a mouse line carrying a Padi6 missense variant that was identified in a family with Beckwith-Wiedemann syndrome and MLID...
March 7, 2024: Genes & Development
https://read.qxmd.com/read/38453480/psat1-generated-%C3%AE-ketoglutarate-and-glutamine-promote-muscle-stem-cell-activation-and-regeneration
#36
JOURNAL ARTICLE
Veronica Ciuffoli, Xuesong Feng, Kan Jiang, Natalia Acevedo-Luna, Kyung Dae Ko, A Hong Jun Wang, Giulia Riparini, Mamduh Khateb, Brian Glancy, Stefania Dell'Orso, Vittorio Sartorelli
By satisfying bioenergetic demands, generating biomass, and providing metabolites serving as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we report that a branch of glycolysis, the serine biosynthesis pathway (SBP), is activated in regenerating muscle stem cells (MuSCs). Gene inactivation and metabolomics revealed that Psat1, one of the three SBP enzymes, controls MuSC activation and expansion of myogenic progenitors through production of the metabolite α-ketoglutarate (α-KG) and α-KG-generated glutamine...
March 7, 2024: Genes & Development
https://read.qxmd.com/read/38451982/the-prevalence-of-and-factors-associated-with-depressive-and-anxiety-symptoms-during-the-covid-19-pandemic-among-healthcare-workers-in-south-africa
#37
JOURNAL ARTICLE
Megan Pool, Katherine Sorsdahl, Bronwyn Myers, Claire van der Westhuizen
INTRODUCTION: Healthcare workers globally have experienced increased social and occupational stressors in their working environments and communities because of COVID-19 which has increased the risk of mental health concerns. This study aimed to explore the prevalence and correlates of depression and anxiety amongst healthcare workers during the COVID-19 pandemic in the Western Cape, South Africa. In addition, role-related stressors and coping strategies were explored. MATERIAL AND METHODS: We conducted a cross-sectional survey of doctors and nurses working in public healthcare facilities across the Western Cape, South Africa...
2024: PloS One
https://read.qxmd.com/read/38451887/variations-in-anxiety-and-emotional-support-among-first-year-college-students-across-different-learning-modes-distance-and-face-to-face-during-covid-19
#38
JOURNAL ARTICLE
Flor Rocío Ramírez-Martínez, Maria Theresa Villanos, Sonam Sharma, Marie Leiner
College students with more emotional support experience lower levels of anxiety and other psychosocial and behavioral problems. During the COVID-19 pandemic, the emotional well-being of college students was additionally challenged by an abrupt shift to distance learning followed by a return to face-to-face classes. In this exploratory study, we compared the levels of perceived emotional support and anxiety among incoming first-year undergraduate students, prior to starting classes, which included different learning modes in five semesters of instruction from 2021-2023 (three distance semesters and two face-to-face semesters)...
2024: PloS One
https://read.qxmd.com/read/38451392/longitudinal-relationships-between-depressive-symptoms-and-generalized-anxiety-symptoms-in-adolescents-a-cross-lagged-network-analysis
#39
JOURNAL ARTICLE
Chunyang Zhang, Jingyuan Huang, Wei Xu
The comorbidity of depression and generalized anxiety have raised questions about the existing classification system. Based on the perspective of network analysis, the developmental relationship between psychological symptoms can be explored more clearly. The current study aimed to explore the longitudinal network association of depressive symptoms and generalized anxiety symptoms in non-clinical adolescents. The sample contained 1,947 Chinese adolescents (Mage  = 13.93, SD = 1.71; 48...
March 7, 2024: Journal of Youth and Adolescence
https://read.qxmd.com/read/38450643/comparison-of-n-glycopeptide-to-released-n-glycan-abundances-and-the-influence-of-glycopeptide-mass-and-charge-states-on-n-linked-glycosylation-of-igg-antibodies
#40
JOURNAL ARTICLE
Concepcion A Remoroza, Meghan C Burke, Tytus D Mak, Sergey L Sheetlin, Yuri A Mirokhin, Brian T Cooper, Zachary C Goecker, Mark S Lowenthal, Xiaoyu Yang, Guanghui Wang, Dmitrii V Tchekhovskoi, Stephen E Stein
We report the comparison of mass-spectral-based abundances of tryptic glycopeptides to fluorescence abundances of released labeled glycans and the effects of mass and charge state and in-source fragmentation on glycopeptide abundances. The primary glycoforms derived from Rituximab, NISTmAb, Evolocumab, and Infliximab were high-mannose and biantennary complex galactosylated and fucosylated N-glycans. Except for Evolocumab, in-source ions derived from the loss of HexNAc or HexNAc-Hex sugars are prominent for other therapeutic IgGs...
March 7, 2024: Journal of Proteome Research
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