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Jamil Manji, Jayakar V Nayak, Andrew Thamboo
BACKGROUND: Empty nose syndrome (ENS) is a debilitating disorder thought to arise as a postsurgical phenomenon from excessive loss of nasal tissues. Affected patients often report a profound impact on all aspects of life, but the extent of this burden has not been quantified. We sought to determine the association of ENS with mental health and functional impairments. METHODS: A cross-sectional study was performed of individuals with ENS recruited from online ENS forums...
February 14, 2018: International Forum of Allergy & Rhinology
Ahmad Daif, Rimas V Lukas, Naoum P Issa, Adil Javed, Stephen VanHaerents, Anthony T Reder, James X Tao, Peter Warnke, Sandra Rose, Vernon L Towle, Shasha Wu
Glutamic acid decarboxylase (GAD) antibody-associated encephalitis causes both acute seizures and chronic epilepsy with predominantly temporal lobe onset. This condition is challenging in diagnosis and management, and the incidence of GAD antibody (Ab)-related epilepsy could be much higher than commonly believed. Imaging and CSF evidence of inflammation along with typical clinical presentations, such as adult onset temporal lobe epilepsy (TLE) with unexplained etiology, should prompt testing for the diagnostic antibodies...
February 9, 2018: Epilepsy & Behavior: E&B
Anat Milman, Gad Keren
Electrocardiography abnormalities are a common finding in athletes. To facilitate the differentiation of physiological adaptation versus pathological remodeling, a series of guidelines has emerged in the past decade that attempt to improve specificity while maintaining a high sensitivity. Recently, T wave inversion in the athletic population gained more attention, resulting in accelerated research leading to novel findings not yet integrated into clinical practice. We aim to simplify the knowledge to date and integrate it into one easy to use practical flowchart...
February 2018: Israel Medical Association Journal: IMAJ
Robert Zymliński, Jan Biegus, Mateusz Sokolski, Paweł Siwołowski, Sylwia Nawrocka-Millward, John Todd, Ewa A Jankowska, Waldemar Banasiak, Gad Cotter, John G Cleland, Piotr Ponikowski
AIMS: Lactate is produced by anaerobic metabolism and may reflect inadequate tissue perfusion in conditions such as acute heart failure (AHF). We evaluated the prevalence and clinical significance of elevated blood lactate on admission in patients with AHF. METHODS AND RESULTS: We enrolled 237 patients with AHF (mean age 67 ± 12 years; 70% men) presenting without overt clinical evidence of peripheral hypoperfusion ('warm haemodynamic profile'). Median (upper and lower quartiles) blood lactate on admission was 1...
February 12, 2018: European Journal of Heart Failure
Dror Limon, Omer Gal, Noa Gordon, Lior Katz, Gali Perl, Ofer Purim, Limor Amit, Salomon M Stemmer, Yulia Kundel, Irit Ben-Aharon, Baruch Brenner, Tali Siegal, Shlomit Yust-Katz
The increased survival of patients with gastroesophageal adenocarcinoma (GAD) following improvements in treatment has been accompanied by a rising incidence of secondary brain metastasis. HER2 amplification/overexpression, which has been associated with an increased risk of brain metastasis in breast cancer, is found in about 20% of patients with GAD. The aim of this study was to evaluate the effect of HER2 status on brain metastasis in GAD. The database of a tertiary cancer center was searched for patients with GAD diagnosed in 2011-2015, and data were collected on clinical characteristics, brain metastasis, HER2 status, and outcome...
February 10, 2018: Journal of Neuro-oncology
Pascal Jordan, Meike C Shedden-Mora, Bernd Löwe
OBJECTIVE: To obtain predictors of suicidal ideation, which can also be used for an indirect assessment of suicidal ideation (SI). To create a classifier for SI based on variables of the Patient Health Questionnaire (PHQ) and sociodemographic variables, and to obtain an upper bound on the best possible performance of a predictor based on those variables. METHODS: From a consecutive sample of 9025 primary care patients, 6805 eligible patients (60% female; mean age = 51...
February 2, 2018: General Hospital Psychiatry
Carrie B Gillett, Emily L Bilek, Gregory L Hanna, Kate D Fitzgerald
Obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) are early-onset disorders with significant overlapping phenomenology, especially in young patients who, due to developmental stage, may have difficulty recognizing obsessions and worries as unrealistic or excessive. Shared phenomenology and high rates of comorbidity between OCD and GAD raise the possibility of common underlying processes, and recent work has focused on intolerance of uncertainty (IU) as a reasonable candidate. With an emphasis on the youth literature, we review the phenomenological overlap between OCD and GAD, how symptoms may relate to IU, and how IU may be measured...
February 2, 2018: Clinical Psychology Review
Ayman Lotfy, Ahmed A M Gad, Ayman Abdelrahman, Ahmed Samir, Bahaa-Eldin Hasan Abdulhalim
PURPOSE: To evaluate and compare the recurrence rate and complications of conjunctival autograft (CAG) combined with preoperative mitomycin C (MMC) injection versus CAG with intraoperative local MMC over the medial rectus muscle tendon in primary pterygium. STUDY DESIGN: Randomized prospective study. METHODS: This study included 108 eyes of 108 patients with primary fleshy or growing pterygium. All patients were from rural areas and less than 50 years old...
February 7, 2018: Eye & Contact Lens
Astrid Junge, Birgit Prinz
BACKGROUND: Information on the prevalence of mental health problems of elite athletes is inconclusive, most probably due to methodological limitations, such as low response rates, heterogeneous samples. AIMS: To evaluate the prevalence and risk factors of depression and anxiety symptoms in high-level female football players. METHODS: Female football players of 10 German first league (Bundesliga) and 7 lower league teams were asked to answer a questionnaire on players' characteristics, the Center of Epidemiologic Studies Depression Scale (CES-D) and the Generalised Anxiety Disorder (GAD-7) scale...
February 2, 2018: British Journal of Sports Medicine
Konstantinos Tsaras, Ioanna V Papathanasiou, Viktor Vus, Antigoni Panagiotopoulou, Maria Alexandra Katsou, Martha Kelesi, Evangelos C Fradelos
Introduction: The nursing profession is characterized as one of the most stressful and emotional dementing professions. It is widely agreed that many nurses are experiencing anxiety and depression as a results of their profession. Purpose: The purpose of this study was to assess the prevalence and associated factors of depression and anxiety among mental health nurses working in public psychiatric hospitals, in order to identify independent predictors of mental health disorders risk...
February 2018: Medical Archives
Luciana F Franco, Renata Peixoto-Barbosa, Renata P Dotto, José Gilberto H Vieira, Magnus R Dias-da-Silva, Luiz Carlos F Reis, Fernando M A Giuffrida, Andre F Reis
Identification of the correct etiology of diabetes brings important implications for clinical management. In this report, we describe a case of a 4-year old asymptomatic girl with diabetes since age 2, along with several individuals in her family with different etiologies for hyperglycemia identified in youth. Genetic analyses were made by Sanger sequencing, laboratory measurements included HbA1c, lipid profile, fasting C-peptide, pancreatic auto-antibodies (glutamic acid decarboxylase [GAD], Islet Antigen 2 [IA-2], and anti-insulin)...
December 2017: Archives of Endocrinology and Metabolism
Sara R Fedorka, Kevin So, Ayad A Al-Hamashi, Ibtissam Gad, Ronit Shah, Veronika Kholodovych, Hanan D Alqahtani, William R Taylor, L M Viranga Tillekeratne
In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin but instead kills selected cancer cell lines by harnessing reactive oxygen species in an iron-dependent manner. Results of the preliminary studies are consistent with the recently described cell death mechanism ferroptosis. Studies are in progress to confirm ferroptosis as the cell death mechanism and to identify the specific molecular targets of these small molecule anticancer agents...
February 7, 2018: Organic & Biomolecular Chemistry
Marta Cristina Cunha-Rodrigues, Cassiana Thayara do Nascimento Balduci, Frank Tenório, Penha Cristina Barradas
Intrauterine adverse conditions may be responsible for long-lasting damages which impact health even during adult phase. Hypoxic-ischemic (HI) events are a relevant cause of newborn mortality and the principal factor leading to permanent brain lesions. Using a model in which the ovarian and uterine flux of a pregnant rat is obstructed for 45 minutes we have described oligodendrocyte death, astrogliosis and neuronal loss. In this work we investigated hippocampal neuronal population and performed a functional evaluation of memory and learning of young rats that had been affected by prenatal HI...
February 3, 2018: Neurobiology of Learning and Memory
Edgardo Cristiano, Ricardo Alonso, Amelia Alvez Pinheiro, Elizabeth A Bacile, María Eugenia Balbuena, Carlos Ballario, Andrés G Barboza, Santiago Bestoso, Marcos Burgos, Fernando Cáceres, Edgar Carnero Contentti, Adriana Carrá, Ernesto Crespo, María Celeste Curbelo, Normah Deri, Jorge Fernandez, Nora Fernández Liguori, Marcela Fiol, María Ines Gaitán, Orlando Garcea, Diego Giunta, Mario J Halfon, Javier P Hryb, Miguel Jacobo, Eduardo Kohler, Ramiro Linares, Geraldine G Luetic, Alejandra D Martínez, Jimena Míguez, Pedro G Nofal, Liliana Patrucco, Raúl Piedrabuena, Juan Ignacio Rojas, Roberto Rotta Escalante, María Laura Saladino, Berenice A Silva, Vladimiro Sinay, Judith D Steinberg, Adriana Tarulla, Santiago A Vétere, Andrés Villa, Cárlos Vrech, María Célica Ysrraelit, Jorge Correale
One of the biggest challenges in multiple sclerosis (MS) is the definition of treatment response/failure in order to optimize treatment decisions in affected patients. The objective of this consensus was to review how disease activity should be assessed and to propose recommendations on the identification of treatment failure in RRMS patients in Argentina. METHODS: A panel of experts in neurology from Argentina, dedicated to the diagnosis and care of MS patients, gathered both virtually and in person during 2016 and 2017 to carry out a consensus recommendation on the identification of treatment failure in RRMS patients...
February 15, 2018: Journal of the Neurological Sciences
Itamar Aroch, Gad Baneth, Harold Salant, Yaarit Nachum-Biala, Asaf Berkowitz, Merav Shamir, Orit Chai
An 8-year-old mixed-breed dog was presented for acute, progressive weakness and ataxia, inappetence, and weight loss. The patient was mentally normal, but nonambulatory, with a right head tilt, right positional ventral strabismus, and slight head tremors. A neurologic lesion was localized to the cerebellum and right brainstem. Cerebrospinal fluid (CSF) analysis showed a markedly increased protein concentration and mixed pleocytosis, with eosinophil predominance (44%), intracytoplasmic inclusions within eosinophils, consistent with Ehrlichia canis (E canis) morulae, and Toxoplasma gondii (T gondii) or Neospora caninum (N caninum) tachyzoites within eosinophils and monocytes...
February 6, 2018: Veterinary Clinical Pathology
Gilad Margolis, Sevan Letourneau-Shesaf, Shafik Khoury, David Pereg, Natalia Kofman, Gad Keren, Yacov Shacham
OBJECTIVE: Delay in seeking medical care following symptom onset in patients with acute ST-elevation myocardial infarction (STEMI) is related to increased morbidity and mortality. Actual trends of prehospital delays in patients hospitalized with STEMI have not been well characterized. We evaluated trends in the length of time that had elapsed from symptom onset to hospital presentation among STEMI patients admitted to our hospital. PATIENTS AND METHODS: We retrospectively studied 2203 consecutive patients hospitalized for acute STEMI who underwent primary percutaneous coronary intervention (PCI) between January 2008 and December 2016...
February 5, 2018: Coronary Artery Disease
Chunlin Li, Shanshan Su, Hongyun Wu, Yilin Zhu
This study aimed to examine the spontaneous hemodynamic fluctuations and the dysfunctional brain regions in patients with generalized anxiety disorder (GAD) using resting-state functional MRI. Previous studies have demonstrated some neural networks that are different in this patient group compared with healthy controls. However, there is still a need for precise anatomical localization of the aberrantly operating networks. We used resting-state functional MRI to measure the hemodynamic fluctuations in 31 GAD patients and 31 control participants matched for sex, age, and education...
February 5, 2018: Neuroreport
Danthanh Hoang, Nayaab Khawar, Maria George, Ashraf Gad, Farrah Sy, Pramod Narula
OBJECTIVE: To increase the hand-washing (HW) duration of staff and visitors in the NICU to a minimum of 20 seconds as recommended by the CDC. METHODS: Intervention included video didactic triggered by motion sensor to play above wash basin. Video enacted Centers for Disease Control and Prevention (CDC) HW technique in real time and displayed timer of 20 seconds. HW was reviewed from surveillance video. Swabs of hands plated and observed for qualitative growth (QG) of bacterial colonies...
February 6, 2018: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
AbdAllah Gad, Sajjad Ali, Talal Zahoor, Nick Azarov
Malarial infections are uncommon in the United States and almost all reported cases stem from recent travelers coming from endemic countries. Cerebral malaria (CM) is a severe form of the disease usually affecting children and individuals with limited immunity. Despite proper management, mortality from CM can reach up to 25%, especially when it is associated with brain edema. Inefficient management of the edema may result in brain herniation and death. Uniform guidelines for management of CM-associated brain edema are lacking...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
Enas A M R Afify, Ibrahim Elsayed, Mary K Gad, Magdy I Mohamed, Abd El-Moneim M R Afify
Dorzolamide hydrochloride is frequently administered for the control of the intra-ocular pressure associated with glaucoma. The aim of this study is to develop and optimize self-assembled nanostructures of dorzolamide hydrochloride and L-α-Phosphatidylcholine to improve the pharmacokinetic parameters and extend the drug pharmacological action. Self-assembled nanostructures were prepared using a modified thin-film hydration technique. The formulae compositions were designed based on response surface statistical design...
2018: PloS One
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