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https://www.readbyqxmd.com/read/29036899/targeting-strategies-for-the-combination-treatment-of-cancer-using-drug-delivery-systems
#1
REVIEW
Janel Kydd, Rahul Jadia, Praveena Velpurisiva, Aniket Gad, Shailee Paliwal, Prakash Rai
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment-due to the hostile tumor microenvironment-that create a significant challenge for effective therapeutic regimens. Multidrug resistance, collateral toxicity to normal cells, and detrimental systemic side effects present significant obstacles, necessitating alternative and safer treatment strategies. Traditional administration of chemotherapeutics has demonstrated minimal success due to the non-specificity of action, uptake and rapid clearance by the immune system, and subsequent metabolic alteration and poor tumor penetration...
October 14, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29033080/reconstitution-of-th17-tc17-and-treg-cells-after-paediatric-haematopoietic-stem-cell-transplantation-impact-of-interleukin-7
#2
Katrine Kielsen, Lars P Ryder, David Lennox-Hvenekilde, Monika Gad, Claus H Nielsen, Carsten Heilmann, Marianne Ifversen, Anders Elm Pedersen, Klaus Müller
Successful reconstitution of T lymphocytes after allogeneic haematopoietic stem cell transplantation (HSCT) is needed to establish the graft-versus-leukaemia effect and an effective anti-microbial defense, but the ratio between functionally different T-cell subsets needs to be balanced to avoid graft-versus-host disease (GVHD). IL-7 is essential for T-cell generation in the thymus and peripheral T-cell homeostasis. High IL-7 levels have been associated with impaired T-cell reconstitution, increased risk of acute GVHD and treatment-related mortality, but the underlying cellular mechanisms behind these associations have not been investigated previously...
October 9, 2017: Immunobiology
https://www.readbyqxmd.com/read/29031852/inhibition-of-cdk5-rejuvenates-inhibitory-circuits-and-restores-experience-dependent-plasticity-in-adult-visual-cortex
#3
Yue Li, Laijian Wang, Xinxin Zhang, Mengyao Huang, Sitong Li, Xinxing Wang, Lin Chen, Bin Jiang, Yupeng Yang
Cyclin-dependent kinase 5 (Cdk5) acts as an essential modulator for neural development and neurological disorders. Here we show that Cdk5 plays a pivotal role in modulating GABAergic signaling and the maturation of visual system. In adult mouse primary visual cortex, Cdk5 formed complex with the GABA synthetic enzyme glutamate decarboxylase GAD67, but not with GAD65. In addition to enhancement in the surface level of NR2B-containing NMDA receptors, inhibition of Cdk5 reduced the protein levels of GADs and Otx2, while leaving intact the expression of vesicular GABA transporter and subunits of GABAA or AMPA receptors...
October 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29028873/mirna-in-tumour-metabolism-and-why-could-it-be-the-preferred-pathway-for-energy-reprograming
#4
Aliaa A Alamoudi, Amina Alnoury, Hoda Gad
The current literature on the role of microRNA (miRNA) in tumour metabolism is growing, and a number of studies regularly confirm the impact miRNA can have in energy reprograming in tumours. However, there remains to be a lack of understanding of the larger perspective of the role of miRNA in the metabolism story. In the first part of this review, we provide a comprehensive and up-to-date description of the extensive role of miRNAs in tumour metabolism including glucose, lipid and amino acid metabolism. However, in the second part, we aim to provide a description of the multidimensional role miRNA can be playing in tumour metabolism...
September 23, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29028610/systematic-review-and-meta-analysis-of-dropout-rates-in-individual-psychotherapy-for-generalized-anxiety-disorder
#5
REVIEW
Elon Gersh, David J Hallford, Simon M Rice, Nikolaos Kazantzis, Hannah Gersh, Benji Gersh, Carolyn A McCarty
BACKGROUND: Despite being a relatively prevalent and debilitating disorder, Generalized Anxiety Disorder (GAD) is the second least studied anxiety disorder and among the most difficult to treat. Dropout from psychotherapy is concerning as it is associated with poorer outcomes, leads to service inefficiencies and can disproportionately affect disadvantaged populations. No study to date has calculated a weighted mean dropout rate for GAD and explored associated correlates. METHODS: A systematic review was conducted using PsycINFO, Medline and Embase databases, identifying studies investigating individual psychotherapies for adults with GAD...
October 6, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29026765/screening-antenatal-anxiety-predicting-its-effect-on-fetal-growth
#6
Kaushik Sarkar, Goutam Das, Ranadip Chowdhury, Bhaskar Shahbabu, Ishita Sarkar, Santu Maiti, Aparajita Dasgupta
CONTEXT: Maternal anxiety has an association with low birth weight. However, studies are scarce to determine any association between maternal anxiety and fetal growth. AIMS: This study aims to determine the effect of maternal anxiety on fetal growth, measured by gestational age-dependent increase in fetal abdominal circumference (AC). The secondary objective is to determine the effect of maternal anxiety on other fetal parameters (biparietal diameter [BPD], head circumference [HC], femur length [FL])...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026609/ketosis-prone-diabetes-and-sle-co-presenting-in-an-african-lady-with-previous-gestational-diabetes
#7
S Hussain, S Keat, S V Gelding
We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). However, the diagnosis of SLE prompted testing for an autoimmune aetiology for the diabetes, and she was found to have a very high titre of GAD antibodies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29025788/brief-mindfulness-meditation-for-depression-and-anxiety-symptoms-in-patients-undergoing-hemodialysis-a-pilot-feasibility-study
#8
Zoë Thomas, Marta Novak, Susanna Gabriela Torres Platas, Maryse Gautier, Angela Potes Holgin, Rebecca Fox, Marilyn Segal, Karl J Looper, Mark Lipman, Steven Selchen, Istvan Mucsi, Nathan Herrmann, Soham Rej
BACKGROUND AND OBJECTIVES: Up to 50% of patients undergoing hemodialysis suffer from symptoms of depression and/or anxiety. Access to traditional pharmacotherapies and psychotherapies for depression or anxiety in this patient population has been inadequate. The objective of this study was to investigate the feasibility and effectiveness of brief mindfulness meditation intervention for patients on hemodialysis with depression and anxiety symptoms. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study was a randomized, controlled, assessor-blinded trial conducted in an urban hemodialysis unit...
October 12, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29024821/improving-the-efficiency-of-psychological-treatment-using-outcome-feedback-technology
#9
Jaime Delgadillo, Karen Overend, Mike Lucock, Martin Groom, Naomi Kirby, Dean McMillan, Simon Gilbody, Wolfgang Lutz, Julian A Rubel, Kim de Jong
AIMS: This study evaluated the impact of applying computerized outcome feedback (OF) technology in a stepped care psychological service offering low and high intensity therapies for depression and anxiety. METHODS: A group of therapists were trained to use OF based on routine outcome monitoring using depression (PHQ-9) and anxiety (GAD-7) measures. Therapists regularly reviewed expected treatment response graphs with patients and discussed cases that were "not on track" in clinical supervision...
September 28, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29022707/bistable-c2-daisy-chain-rotaxanes-as-reversible-muscle-like-actuators-in-mechanically-active-gels
#10
Antoine Goujon, Thomas Lang, Giacomo Mariani, Emilie Moulin, Gad Fuks, Jesus Raya, Eric Buhler, Nicolas Giuseppone
The implementation of molecular machines in polymer science is of high interest to transfer mechanical motions from nanoscale to macroscale in order to access new kinds of active devices and materials. Towards this objective, thermodynamic and topological aspects need to be explored for reaching efficient systems capable of producing a useful work. In this paper we describe the branched polymerization of pH-sensitive bistable [c2]daisy chain rotaxanes by using copper (I) catalyzed Huisgen 1,3-dipolar cycloaddition ("click chemistry")...
October 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29017218/patient-factors-associated-with-failure-of-flap-coverage-used-during-revision-total-knee-arthroplasty
#11
Bishoy V Gad, Joseph F Styron, Mark A Goergy, Alison K Klika, Wael K Barsoum, Carlos A Higuera
No abstract text is available yet for this article.
October 10, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28992899/tailored-online-cognitive-behavioural-therapy-with-or-without-therapist-support-calls-to-target-psychological-distress-in-adults-receiving-haemodialysis-a-feasibility-randomised-controlled-trial
#12
Joanna L Hudson, Rona Moss-Morris, Sam Norton, Federica Picariello, David Game, Amy Carroll, Jonathan Spencer, Paul McCrone, Matthew Hotopf, Lucy Yardley, Joseph Chilcot
BACKGROUND: Psychological distress is prevalent in haemodialysis (HD) patients yet access to psychotherapy remains limited. This study assessed the feasibility and acceptability of online cognitive-behavioural therapy (CBT) tailored for HD patients, with or without therapist support, for managing psychological distress. METHODS: This feasibility randomised controlled trial recruited patients from a UK HD centre. Following psychological distress screens, patients with mild-moderate psychological distress (Patient Health Questionnaire PHQ-9; score: 5-19 and/or Generalised Anxiety Disorder; GAD-7 score: 5-14) who met remaining inclusion criteria were approached for consent...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28991949/post-intensive-care-unit-psychiatric-comorbidity-and-quality-of-life
#13
Sophia Wang, Chris Mosher, Anthony J Perkins, Sujuan Gao, Sue Lasiter, Sikandar Khan, Malaz Boustani, Babar Khan
The prevalence of psychiatric symptoms ranges from 17% to 44% in intensive care unit (ICU) survivors. The relationship between the comorbidity of psychiatric symptoms and quality of life (QoL) in ICU survivors has not been carefully examined. This study examined the relationship between psychiatric comorbidities and QoL in 58 survivors of ICU delirium. Patients completed 3 psychiatric screens at 3 months after discharge from the hospital, including the Patient Health Questionnaire-9 (PHQ-9) for depression, the Generalized Anxiety Disorder-7 (GAD-7) questionnaire for anxiety, and the Post-Traumatic Stress Syndrome (PTSS- 10) questionnaire for posttraumatic stress disorder...
October 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28990850/the-relationship-between-toxoplasma-gondii-igg-antibodies-and-generalized-anxiety-disorder-and-obsessive-compulsive-disorder-in-children-and-adolescents-a-new-approach
#14
İsmail Akaltun, Soner Sertan Kara, Tayfun Kara
AIM: Toxoplasma gondii may play a role in the development of psychiatric diseases by affecting the brain. The purpose of this study was to examine the relation between serum toxoplasma IgG positivity and obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) in children and adolescents. METHOD: Sixty patients diagnosed with OCD and 60 patients with GAD presenting to the pediatric psychiatry clinic, together with 60 control group subjects with no psychiatric diagnosis, were included in the study...
October 9, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28989749/a-geometric-method-for-eigenvalue-problems-with-low-rank-perturbations
#15
Thomas J Anastasio, Andrea K Barreiro, Jared C Bronski
We consider the problem of finding the spectrum of an operator taking the form of a low-rank (rank one or two) non-normal perturbation of a well-understood operator, motivated by a number of problems of applied interest which take this form. We use the fact that the system is a low-rank perturbation of a solved problem, together with a simple idea of classical differential geometry (the envelope of a family of curves) to completely analyse the spectrum. We use these techniques to analyse three problems of this form: a model of the oculomotor integrator due to Anastasio & Gad (2007 J...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28988824/citrobacter-rodentium-subverts-atp-flux-and-cholesterol-homeostasis-in-intestinal-epithelial-cells-in%C3%A2-vivo
#16
Cedric N Berger, Valerie F Crepin, Theodoros I Roumeliotis, James C Wright, Danielle Carson, Meirav Pevsner-Fischer, R Christopher D Furniss, Gordon Dougan, Mally Bachash, Lu Yu, Abigail Clements, James W Collins, Eran Elinav, Gerald J Larrouy-Maumus, Jyoti S Choudhary, Gad Frankel
The intestinal epithelial cells (IECs) that line the gut form a robust line of defense against ingested pathogens. We investigated the impact of infection with the enteric pathogen Citrobacter rodentium on mouse IEC metabolism using global proteomic and targeted metabolomics and lipidomics. The major signatures of the infection were upregulation of the sugar transporter Sglt4, aerobic glycolysis, and production of phosphocreatine, which mobilizes cytosolic energy. In contrast, biogenesis of mitochondrial cardiolipins, essential for ATP production, was inhibited, which coincided with increased levels of mucosal O2 and a reduction in colon-associated anaerobic commensals...
October 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28988769/comprehensive-molecular-characterization-of-muscle-invasive-bladder-cancer
#17
A Gordon Robertson, Jaegil Kim, Hikmat Al-Ahmadie, Joaquim Bellmunt, Guangwu Guo, Andrew D Cherniack, Toshinori Hinoue, Peter W Laird, Katherine A Hoadley, Rehan Akbani, Mauro A A Castro, Ewan A Gibb, Rupa S Kanchi, Dmitry A Gordenin, Sachet A Shukla, Francisco Sanchez-Vega, Donna E Hansel, Bogdan A Czerniak, Victor E Reuter, Xiaoping Su, Benilton de Sa Carvalho, Vinicius S Chagas, Karen L Mungall, Sara Sadeghi, Chandra Sekhar Pedamallu, Yiling Lu, Leszek J Klimczak, Jiexin Zhang, Caleb Choo, Akinyemi I Ojesina, Susan Bullman, Kristen M Leraas, Tara M Lichtenberg, Catherine J Wu, Nicholaus Schultz, Gad Getz, Matthew Meyerson, Gordon B Mills, David J McConkey, John N Weinstein, David J Kwiatkowski, Seth P Lerner
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival "neuronal" subtype in which the majority of tumors lacked small cell or neuroendocrine histology...
October 4, 2017: Cell
https://www.readbyqxmd.com/read/28988523/immunopathology-in-drug-resistant-mesial-temporal-lobe-epilepsy-with-different-types-of-hippocampal-sclerosis
#18
F Irsel Tezer, Aysegul Firat, Erdem Tuzun, Isik Unal, Figen Soylemezoglu, Burcak Bilginer, Figen Kaymaz, Kader K Oguz, Serap Saygi
PURPOSE: There is evidence that autoimmunity has a specific role in temporal lobe seizures of limbic encephalitis patients. Our aim in this study was to investigate any histopathological clues of autoimmune process in refractory temporal lobe epilepsy (TLE) patients with different pathologically proven hippocampal sclerosis (HS) types. METHODS: 22 patients who had undergone to epilepsy surgery due to mesial TLE-HS were included. The sera of patients are tested for neuronal antibodies to NMDAR, LGI1, CASPR2, AMPAR, GABABR and GAD...
October 7, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28987750/metabolic-risk-profiles-in-diabetes-stratified-according-to-age-at-onset-islet-autoimmunity-and-fasting-c-peptide
#19
Mette Wod, Knud B Yderstræde, Ulrich Halekoh, Henning Beck-Nielsen, Kurt Højlund
OBJECTIVE: Islet autoimmunity, age at onset and time to insulin treatment are often used to define subgroups of diabetes. However, the latter criterion is not clinical useful. Here, we examined whether an unbiased stratification of diabetes according to age at onset, fasting C-peptide and GAD autoantibodies (GADab) defines groups with differences in glycaemic control and markers of cardiometabolic risk. DESIGN AND METHODS: A cohort of 4,374 adults with relatively newly diagnosed diabetes referred to a Danish hospital during 1997-2012 was stratified according to age at onset above or below 30 years, fasting C-peptide above or below 300 pmol/l (CPEPhigh or CPEPlow), and presence or absence of GADab (GADpos or GADneg)...
October 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28986703/relationship-between-baseline-systolic-blood-pressure-and-long-term-outcomes-in-acute-heart-failure-patients-treated-with-trv027-an-exploratory-subgroup-analysis-of-blast-ahf
#20
Gad Cotter, Beth A Davison, Javed Butler, Sean P Collins, Justin A Ezekowitz, G Michael Felker, Gerasimos Filippatos, Phillip D Levy, Marco Metra, Piotr Ponikowski, John R Teerlink, Adriaan A Voors, Stefanie Senger, David Bharucha, Kathleen Goin, David G Soergel, Peter S Pang
INTRODUCTION: TRV027, a 'biased' ligand of the angiotensin II type 1 receptor (AT1R), did not affect a composite clinical outcome at 30 days in a phase 2b acute heart failure (AHF) trial (BLAST-AHF). METHODS: Post-hoc analyses from BLAST-AHF (n = 618) examined the effects of TRV027 by baseline systolic blood pressure (SBP) on changes in renal function and 180-day outcomes. Interactions between baseline SBP and select endpoints were identified utilizing a subpopulation treatment effect pattern plots (STEPP) analysis, then grouping of patients by SBP tertile: < 127, ≥ 127 to < 140, and ≥ 140 mmHg...
October 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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