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https://www.readbyqxmd.com/read/29236152/transport-pathway-and-source-area-for-artemisia-pollen-in-beijing-china
#1
Xiaoxin Qin, Yiyin Li, Xu Sun, Ling Meng, Xiaoke Wang
Artemisia pollen is an important allergen responsible for allergic rhinitis in Beijing, China. To explore the transport pathways and source areas of Artemisia pollen, we used Burkard 7-day traps to monitor daily pollen concentrations in 2016 in an urban and suburban locality. Backward trajectories of 24- and 96-h and their cluster analysis were performed to identify transport pathways of Artemisia pollen using the HYSPLIT model on 0.5° × 0.5° GADS meteorological data. The potential source contribution function (PSCF) and concentration weighted trajectory (CWT) were calculated to further identify the major potential source areas at local, regional, and long-range scales...
December 13, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29232735/clinical-outcome-of-urgent-thoracotomy-in-patients-with-penetrating-and-blunt-chest-trauma-a-retrospective-survey
#2
Yael Refaely, Leonid Koyfman, Michael Friger, Leonid Ruderman, Mahmud Abu Saleh, Gidon Sahar, Gad Shaked, Moti Klein, Evgeni Brotfain
No abstract text is available yet for this article.
December 12, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29232558/high-throughput-phenotyping-of-lung-cancer-somatic-mutations
#3
Alice H Berger, Angela N Brooks, Xiaoyun Wu, Yashaswi Shrestha, Candace Chouinard, Federica Piccioni, Mukta Bagul, Atanas Kamburov, Marcin Imielinski, Larson Hogstrom, Cong Zhu, Xiaoping Yang, Sasha Pantel, Ryo Sakai, Jacqueline Watson, Nathan Kaplan, Joshua D Campbell, Shantanu Singh, David E Root, Rajiv Narayan, Ted Natoli, David L Lahr, Itay Tirosh, Pablo Tamayo, Gad Getz, Bang Wong, John Doench, Aravind Subramanian, Todd R Golub, Matthew Meyerson, Jesse S Boehm
No abstract text is available yet for this article.
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232246/the-role-of-fdg-pet-in-diabetic-myonecrosis-a-rare-and-underrecognized-complication-of-diabetes
#4
Guillaume Chaussé, Gad Abikhzer
A 66-year-old man with poorly controlled type 2 diabetes was admitted for acute bilateral calf pain in the context of coronary artery disease, chronic renal failure, and peripheral neuropathy. Lower-extremity Doppler ultrasound excluded deep vein thrombosis. FDG-PET was performed to exclude a suspected infection because of elevated white blood cells and inflammatory markers but normal creatinine kinase levels. PET scan demonstrated intense bilateral calf muscle and left thigh muscle uptake, which in combination with the patient's history was consistent with diabetic myonecrosis, a rare end-stage complication of diabetes...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29229736/comparison-of-salmonella-enterica-serovars-typhi-and-typhimurium-reveals-typhoidal-specific-responses-to-bile
#5
Rebecca Johnson, Matt Ravenhall, Derek Pickard, Gordon Dougan, Alexander Byrne, Gad Frankel
Salmonella enterica serovars Typhi and Typhimurium cause typhoid fever and gastroenteritis respectively. A unique feature of typhoid infection is asymptomatic carriage within the gallbladder, which is linked with S Typhi transmission. Despite this, S Typhi responses to bile have been poorly studied. RNA-Seq of S Typhi Ty2 and a clinical S Typhi isolate belonging to the globally dominant H58 lineage (129-0238), as well as S Typhimurium 14028, revealed that 249, 389 and 453 genes respectively were differentially expressed in the presence of 3% bile compared to control cultures lacking bile...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29224581/executive-function-and-other-cognitive-deficits-are-distal-risk-factors-of-generalized-anxiety-disorder-9-years-later
#6
Nur Hani Zainal, Michelle G Newman
OBJECTIVE: The cognitive model (Hirsch & Mathews, 2012) and attentional control theory (Eysenck & Derakshan, 2011) postulate that compromised executive function (EF) and other cognitive constructs are negatively linked to increased excessive and uncontrollable worry, the core symptom of generalized anxiety disorder (GAD). However, the prospective link between neuropsychological constructs and GAD are not well understood. METHODS: A nationally representative sample of 2605 community-dwelling adults whose average age was 55...
December 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29223171/caregiver-burden-sleep-quality-depression-and-anxiety-in-dementia-caregivers-a-comparison-of-frontotemporal-lobar-degeneration-dementia-with-lewy-bodies-and-alzheimer-s-disease
#7
Shuai Liu, Jing Liu, Xiao-Dan Wang, Zhihong Shi, Yuying Zhou, Jing Li, Tao Yu, Yong Ji
BACKGROUND: Very few recent studies are available that compare caregiver burden, sleep quality, and stress in caregivers of different types of dementia. We aimed to investigate caregiver burden, sleep quality, and stress in caregivers of patients with frontotemporal lobar degeneration and dementia with Lewy bodies, as compared with caregivers of patients with Alzheimer's disease. METHODS: This study was carried out from March 2011 to January 2014. In total, 492 dyads of patient and caregiver (frontotemporal lobar degeneration, n = 131; dementia with Lewy bodies, n = 36; Alzheimer's disease, n = 325) participated in this study...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29220505/metabolic-characteristics-of-recently-diagnosed-adult-onset-autoimmune-diabetes-mellitus
#8
Oana P Zaharia, Pavel Bobrov, Klaus Strassburger, Kálmán Bódis, Yanislava Karusheva, Michaela Scholz, Daniel F Markgraf, Volker Burkart, Nanette C Schloot, Karsten Müssig, Julia Szendroedi, Michael Roden
Context and Objective: Among patients diagnosed with type 2 diabetes, autoimmune diabetes often remains undetected. Metabolic features of these patients are insufficiently characterized at present. Design, Setting and Patients: This study compared age- and sex-matched adult (41-62 years) humans with recent-onset diabetes: patients positive for antibodies against glutamic acid decarboxylase (GAD) and/or cytoplasmic islet-cell antigen with an insulin-free period of >6 months (ab+/ins-; previously termed latent autoimmune diabetes of adults, LADA), type 1 (ab+/ins+), type 2 diabetes (ab-/ins-) and glucose-tolerant humans (controls) of the German Diabetes Study (n=41/group)...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29218727/gabaa-and-gabab-receptor-subunit-localisation-on-neurochemically-identified-neurons-of-the-human-subthalamic-nucleus
#9
Xi Hua Wu, Jennifer Junru Song, Richard Lewis Maxwell Faull, Henry John Waldvogel
The subthalamic nucleus (STN) is a critical excitatory signalling centre within the basal ganglia circuitry. The activity of subthalamic neurons is tightly controlled by upstream inhibitory signalling centres in the basal ganglia. In this study, we used immunohistochemical techniques to firstly, visualise and quantify the STN neurochemical organisation based on neuronal markers including parvalbumin (PV), calretinin (CR), SMI-32 and GAD65/67 . Secondly, we characterised the detailed regional, cellular and subcellular expression of GABAA (α1 , α2 , α3 , β2/3 and γ2 ) and GABAB (R1 and R2) receptor subunits within the normal human STN...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29216675/validation-of-a-new-web-based-system-for-point-of-care-implant-documentation-in-total-knee-arthroplasty
#10
Deepak Ramanathan, Bishoy V Gad, Matthew R Luckett, Alison K Klika, Kurt P Spindler, Carlos A Higuera
No abstract text is available yet for this article.
December 7, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29209545/difficult-to-treat-focal-stiff-person-syndrome-of-the-left-upper-extremity
#11
Nathan E Esplin, John W Stelzer, Timothy B Legare, Sayed K Ali
Background: Stiff person syndrome (SPS) is a rare neurologic disorder characterized by muscle rigidity. It is a disorder of reduced GABA activity leading to increased muscle tone and often painful spasms. It generally presents in the axial musculature but rarely can involve only one limb, typically a lower extremity. In rare cases it can be paraneoplastic which generally resolves on treatment of the underlying neoplasm. Case Report: A 46-year-old male with a history of Hodgkin's Lymphoma in remission presented with left upper extremity pain secondary to a diagnosis of Stiff Person Syndrome limited to his left upper extremity...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29204388/clinic-based-group-multi-professional-education-causes-significant-decline-in-psoriasis-severity-a-randomized-open-label-pilot-study
#12
Shubh Mohan Singh, Tarun Narang, Keshavamurthy Vinay, Aditi Sharma, Ashirbad Satapathy, Sanjeev Handa, Sunil Dogra
Background: The evidence for efficacy of psychoeducational interventions in psoriasis is not well researched. Objective: The objective of this study was to assess the benefits of a group, multi-professional, psychoeducational training in psoriasis. Materials and Methods: Adults with moderate-to-severe psoriasis were randomized into psychoeducational intervention plus treatment (intervention arm [IA]) and treatment as usual alone (control arm [CA]) groups using random number tables...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29201987/axillary-lymph-node-metastasis-in-ovarian-carcinoma-two-case-reports-and-review-of-literature
#13
Ram Eitan, Daliah Tsoref, Gad Sabah, Lina Salman
•Extra-peritoneal metastasis is uncommon in epithelial ovarian carcinoma.•Metastasis of epithelial ovarian carcinoma to axillary lymph node is rare.•Lymphatic drainage system can explain the rout of this distant metastasis.•Tissue diagnosis is the mainstay in identifying the origin of axillary metastasis.
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29201327/stiff-person-case-misdiagnosed-as-conversion-disorder-a-case-report
#14
Saeed Razmeh, Amir Hasan Habibi, Farzad Sina, Elham Alizadeh, Monireh Eslami
Background: Stiff person syndrome (SPS) is a rare neurological disease resulting in stiffness and spasm of muscles. It initially affects the axial muscles and then spread to limb muscles. Emotional stress exacerbated the symptoms and signs of the disease. The pathophysiology of the disease is caused by the decreased level of the glutamic acid decarboxylase (GAD) activity due to an autoantibody against GAD that decreases the level of gamma-aminobutyric acid (GABA). In this paper, we present a case of atypical presentation of SPS with lower limb stiffness misdiagnosed as conversion disorder...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29200198/netsig-network-based-discovery-from-cancer-genomes
#15
Heiko Horn, Michael S Lawrence, Candace R Chouinard, Yashaswi Shrestha, Jessica Xin Hu, Elizabeth Worstell, Emily Shea, Nina Ilic, Eejung Kim, Atanas Kamburov, Alireza Kashani, William C Hahn, Joshua D Campbell, Jesse S Boehm, Gad Getz, Kasper Lage
Methods that integrate molecular network information and tumor genome data could complement gene-based statistical tests to identify likely new cancer genes; but such approaches are challenging to validate at scale, and their predictive value remains unclear. We developed a robust statistic (NetSig) that integrates protein interaction networks with data from 4,742 tumor exomes. NetSig can accurately classify known driver genes in 60% of tested tumor types and predicts 62 new driver candidates. Using a quantitative experimental framework to determine in vivo tumorigenic potential in mice, we found that NetSig candidates induce tumors at rates that are comparable to those of known oncogenes and are ten-fold higher than those of random genes...
December 4, 2017: Nature Methods
https://www.readbyqxmd.com/read/29199177/inhibition-of-glycogen-phosphorylase-stimulates-ventromedial-hypothalamic-nucleus-amp-activated-protein-kinase-activity-and-neuronal-nitric-oxide-synthase-protein-expression-in-male-rats
#16
Hussain N Alhamami, Ayed Alshamrani, Karen P Briski
The glucose polymer glycogen is a vital fuel reserve in the brain. The mediobasal hypothalamic energy sensor AMP-activated protein kinase (AMPK) maintains glucostasis via neurotransmitter mechanisms that suppress [γ-aminobutyric acid; GABA] or stimulate [nitric oxide; steroidogenic factor-1 (SF1)] counter-regulatory outflow. This study investigated whether glycogen-derived fuel supply is a critical screened variable in ventromedial hypothalamic nucleus (VMN) monitoring of neuro-metabolic stability during glucostasis and/or insulin (I)-induced hypoglycemia...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29198292/polysomnography-detected-bruxism-in-children-is-associated-with-somatic-complaints-but-not-anxiety
#17
Candice A Alfano, Joanne L Bower, Jessica M Meers
STUDY OBJECTIVES: Sleep bruxism (SB) is common in children and is associated with somatic symptoms and sleep disturbance. Etiological theories posit the role of anxiety, suggesting youth with anxiety disorders may be at high risk for SB, but empirical data are lacking. Furthermore, parent report rather than polysomnography (PSG) has been used to examine SB-anxiety relationships in children. We examined rates of PSG-detected compared to parent-reported SB in children with generalized anxiety disorder (GAD) and healthy controls...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29195588/characteristics-and-clinical-treatment-of-tobacco-smokers-enrolled-in-a-va-substance-use-disorders-clinic
#18
Julie C Gass, David H Morris, Jamie Winters, Joseph W VanderVeen, Stephen Chermack
Individuals with a substance use disorder (SUD) diagnosis are more than twice as likely to smoke cigarettes as the general population. Emerging research has suggested that treating a substance use disorder simultaneously with tobacco use leads to a higher rate of treatment success for both substances. Despite this, substance use treatment protocols tend not to focus on tobacco use; in fact, traditional substance use treatments often discourage patients from attempting to quit smoking. One rationale is that patients may not be motivated to quit smoking...
January 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29195188/long-term-effectiveness-of-cognitive-behavioral-therapy-for-youth-with-anxiety-disorders
#19
Arne Kodal, Krister Fjermestad, Ingvar Bjelland, Rolf Gjestad, Lars-Göran Öst, Jon F Bjaastad, Bente S M Haugland, Odd E Havik, Einar Heiervang, Gro Janne Wergeland
Cognitive behavioral therapy (CBT) has demonstrated favorable long-term outcomes in youth with anxiety disorders in efficacy trials. However, long-term outcomes of CBT delivered in a community setting are uncertain. This study examined the long-term outcomes of individual (ICBT) and group CBT (GCBT) in youth with anxiety disorders treated in community mental health clinics. A total of 139 youth (mean age at assessment 15.5 years, range 11-21 years) with a principal diagnosis of separation anxiety disorder (SAD), social anxiety disorder (SOP), and/or generalized anxiety disorder (GAD) were evaluated, on average, 3...
November 26, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29193711/early-improvement-predicts-8-week-treatment-outcome-in-patients-with-generalized-anxiety-disorder-treated-with-escitalopram-or-venlafaxine
#20
Mincai Qian, Zhongxia Shen, Min Lin, Tiefeng Guan, Jianhong Yang, Liang Li, Xinhua Shen, Yonggui Yuan
INTRODUCTION: To investigate whether early improvement can predict 8-week treatment outcome in generalized anxiety disorder (GAD) patients. METHODS: For 8 weeks, 226 GAD patients were randomly treated with escitalopram or venlafaxine. Early improvement was defined as a ≧20% reduction from baseline in Hamilton anxiety rating scale at week 1 or 2. The positive and negative predictive values were calculated. RESULTS: The positive and negative predictive values of early improvement in escitalopram or venlafaxine group at week 1 were (85...
December 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
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