keyword
https://read.qxmd.com/read/38491792/dual-role-of-mesenchymal-stem-stromal-cells-and-their-cell-free-extracellular-vesicles-in-colorectal-cancer
#1
REVIEW
Mohamed J Saadh, Asma'a H Mohamed, Muhammad Ali Abdullah Almoyad, Omer Qutaiba B Allela, Ali H Amin, April Ann Malquisto, Wong Tze Jin, Ioan Sârbu, Faisal AlShamsi, Fahmy Gad Elsaid, Reza Akhavan-Sigari
Colorectal cancer (CRC) is one of the main causes of cancer-related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer-related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through secreting exosomes. The beneficial properties of stem cells are attributed to their cell-cell interactions as well as the secretion of paracrine factors in the tissue microenvironment...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38490614/highly-effective-and-reusable-ni-al-oxide-zn-0-4-co-0-6-fe-2-o-4-superparamagnetic-aerogel-for-oil-water-separation
#2
JOURNAL ARTICLE
Fagr A Shehata, Amer S El-Kalliny, Mahmoud S Abdel-Wahed, Mohamed S Attia, Tarek A Gad-Allah
Oily wastewater resulting from the oil industry and oil spill accidents has become a serious environmental problem and has attracted attention worldwide. The present study reports on the successful preparation of a novel magnetic Ni-Al oxide/Zn0.4 Co0.6 F2 O4 mesoporous aerogel (MNA) as a highly selective adsorbent for oil removal from water. Oleic acid (OA) and Triton X-100 (TX) were used as hydrophobic agents for MNA surface modification. It was found that the attached amount of OA on the mesoporous MNA aerogel is 3...
March 13, 2024: Chemosphere
https://read.qxmd.com/read/38490592/screening-for-anxiety-in-adolescents-validation-of-the-generalized-anxiety-disorder-assessment-7-in-a-representative-sample-of-adolescents
#3
REVIEW
María Ángeles Casares, Adriana Díez-Gómez, Alicia Pérez-Albéniz, Beatriz Lucas-Molina, Eduardo Fonseca-Pedrero
No abstract text is available yet for this article.
March 13, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38489208/efficacy-of-vagal-nerve-stimulation-on-anxiety-among-elderly-retired-teachers-during-covid-19-pandemic
#4
JOURNAL ARTICLE
Vignesh Srinivasan, Varalakshmi Ruthuvalan, Sakthi Raja, Vanitha Jayaraj, Swathi Sridhar, Muthulakshmi Kothandaraman, Prathap Suganthirababu, Kumaresan Abathsagayam, Surya Vishnuram, Jagatheesan Alagesan, Rajkumar Krishnan Vasanthi
BACKGROUND: Excessive fear, worry and behavioral disturbances define anxiety, with particular significance attributed to vagal nerve, a crucial transmitter of information to the brain regions governing anxiety. Highlighting the importance of vagal nerve, transcutaneous auricular vagal nerve stimulation (TaVNS) emerges as a tolerable and safe technique. The success of non-invasive vagal nerve stimulation in alleviating anxiety underscores the pivotal role of the vagal nerve. OBJECTIVES: The purpose of this study was to assess the effectiveness of physiotherapy interventions in mitigating anxiety among retired teachers during the COVID-19 pandemic, emphasizing the relevance of targeting the vagal nerve for improved mental well-being...
March 15, 2024: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://read.qxmd.com/read/38488454/lost-in-space-s-multimodal-neuroimaging-of-disorientation-along-the-alzheimer-s-disease-continuum
#5
JOURNAL ARTICLE
Gregory Peters-Founshtein, Lidor Gazit, Tahel Naveh, Liran Domachevsky, Amos D Korczyn, Hanna Bernstine, Limor Shaharabani-Gargir, David Groshar, Gad A Marshall, Shahar Arzy
Orientation is a fundamental cognitive faculty and the bedrock of the neurologic examination. Orientation is defined as the alignment between an individual's internal representation and the external world in the spatial, temporal, and social domains. While spatial disorientation is a recognized hallmark of Alzheimer's disease (AD), little is known about disorientation beyond space in AD. This study aimed to explore disorientation in spatial, temporal, and social domains along the AD continuum. Fifty-one participants along the AD continuum performed an ecological orientation task in the spatial, temporal, and social domains while undergoing functional MRI...
March 2024: Human Brain Mapping
https://read.qxmd.com/read/38488019/evaluation-of-novel-synthesized-thiazole-derivatives-as-potential-aromatase-inhibitors-against-breast-cancer
#6
JOURNAL ARTICLE
Eman Fayad, Dalal Nasser Binjawhar, Abeer A Ageeli, Dalal Sulaiman Alshaya, Fahmy Gad Elsaid, Amr Yasser Mahmoud, Eman M Radwan, Ahmed Re Mahdy, Mohamed Ahmed Elian Sophy
Background: 4-Methylacetophenone is used in the preparation of starting materials, 4-methylphenacyle bromide ( 2 ) and 4-methylacetophenone thiosemicarbazole ( 3 ). Results: Several novel 2,4-disubstituted-1,3-thiazole analogues were obtained via the treatment of starting materials with 4-methylphenacyl bromide, acetyl chloride, aromatic aldehydes and bromination providing thiazole derivatives 5-8 respectively. Conclusion: Compounds 5-8 were investigated for their cytotoxic activity on MCF-7 and normal breast cells...
March 15, 2024: Future Medicinal Chemistry
https://read.qxmd.com/read/38487039/exploring-factors-associated-with-quality-of-life-in-caregivers-of-children-and-adolescents-with-sickle-cell-disease-and-hiv-a-comparative-analysis
#7
JOURNAL ARTICLE
Charlotte Eposse Ekoube, Dora Mbonjo Bitsie, Erero F Njiengwe, Edgar Mandeng Ma Linwa, Christian Eyoum, Ritha Mbono Betoko, Jeannette Disso Massako, Emmanuel Heles Nsang, Abba Soumaiyatou, Callixte Tegueu Kuate
INTRODUCTION: Paediatric HIV and sickle cell disease (SCD) are two stigmatising and potentially fatal illnesses that place a significant burden on families. HIV patients benefit from a longstanding free-service national programme in Cameroon, and this could considerably alleviate burden of care on HIV caregivers, possibly leading to better quality of life (QoL) in HIV caregivers compared to SCD caregivers. Our study aimed to compare the QoL between caregivers of children and adolescents with SCD and HIV and explore factors associated with this QoL in Cameroon...
2024: Anemia
https://read.qxmd.com/read/38486196/mental-health-effects-associated-with-covid-19-financial-assistance-in-south-korea-a-comparison-of-employment-status
#8
JOURNAL ARTICLE
Yoonjoo Choi, Eun-Joo Park, Soon-Young Lee, Hee-Yeon Kim, Weon-Young Lee
BACKGROUND: COVID-19 has created tensions across different sectors of the society, but the impact has been unequal. Vulnerable people have been most affected, especially those with insecure employment and who have experienced economic hardships due to unemployment and lost wages. The combination of social change and economic hardships due to the pandemic increases the risk of poor mental health. Some countries have utilized financial assistance to alleviate economic hardships caused by COVID-19, and in South Korea, the central and local governments have implemented COVID-19 financial assistance...
March 14, 2024: BMC Public Health
https://read.qxmd.com/read/38485555/effect-of-cranial-electrotherapy-stimulation-as-an-add-on-therapy-on-late-life-generalized-anxiety-disorder-an-open-label-study
#9
JOURNAL ARTICLE
Che-Sheng Chu, Cheng-Ho Chang, Chih-Chuan Pan, Yung-Chih Chiang, Hsin-Ya Kuo, Tien-Wei Hsu, Shiou-Lan Chen, Cheng-Sheng Chen
INTRODUCTION: Cranial electrotherapy stimulation (CES) is beneficial in reducing anxiety in psychiatric patients. However, no studies have reported on elderly patients with generalized anxiety disorders (GAD). This study aimed to determine the efficacy and safety of a 6-week CES intervention for late-life GAD. MATERIALS AND METHODS: This single-arm pilot study assessed 6-week CES treatment (Alpha-Stim AID) for late-life GAD and 4-week follow-up post intervention...
March 13, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38485267/pan-cellular-organelles-and-suborganelles-from-common-functions-to-cellular-diversity
#10
REVIEW
Rico Schieweck, Magdalena Götz
Cell diversification is at the base of increasing multicellular organism complexity in phylogeny achieved during ontogeny. However, there are also functions common to all cells, such as cell division, cell migration, translation, endocytosis, exocytosis, etc. Here we revisit the organelles involved in such common functions, reviewing recent evidence of unexpected differences of proteins at these organelles. For instance, centrosomes or mitochondria differ significantly in their protein composition in different, sometimes closely related, cell types...
March 14, 2024: Genes & Development
https://read.qxmd.com/read/38485266/a-serine-metabolic-enzyme-is-flexing-its-muscle-to-help-repair-skeletal-muscle
#11
REVIEW
Benjámin R Baráth, Laszlo Nagy
Metabolic reprogramming of stem cells is a targetable pathway to control regeneration. Activation of stem cells results in down-regulation of oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) and turns on glycolysis to provide fuel for proliferation and specific signaling events. How cell type-specific events are regulated is unknown. In this issue of Genes & Development Ciuffoli and colleagues (pp. XXX-XXX) use metabolomic, gene inactivation, and functional approaches to show that phosphoserine aminotransferase (Psat1), an enzyme in serine biosynthesis, is activated in muscle stem cells and contributes to cell expansion and skeletal muscle regeneration via the production of α-ketoglutarate and glutamine...
March 14, 2024: Genes & Development
https://read.qxmd.com/read/38484883/an-investigation-into-the-abnormal-dynamic-connection-mechanism-of-generalized-anxiety-disorders-based-on-non-homogeneous-markov-models
#12
JOURNAL ARTICLE
Qin Tang, Gan Zhang, Yun-Shuang Fan, Wei Sheng, Chenguang Yang, Liju Liu, Xingli Liu, Haoxiang Liu, Yuanhong Guo, Qing Gao, Fengmei Lu, Zongling He, Qian Cui, Huafu Chen
BACKGROUND: The dynamic and hierarchical nature of the functional brain network. The neural dynamical systems tend to converge to multiple attractors (stable fixed points or dynamical states) in long run. Little is known about how the changes in this brain dynamic "long-term" behavior of the connectivity flow of brain network in GAD. METHODS: This study recruited 92 patients with GAD and 77 healthy controls (HC). We applied a reachable probability approach combining a Non-homogeneous Markov model with transition probability to quantify all possible connectivity flows and the hierarchical structure of brain functional systems at the dynamic level and the stationary probability vector (10-step transition probabilities) to describe the steady state of the system in the long run...
March 12, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38484299/digitally-enabled-asynchronous-remote-medical-management-of-anxiety-and-depression-a-cohort-study
#13
JOURNAL ARTICLE
Amichai Perlman, Yishai Pickman, Michael Dreyfuss, Itay Manes, Peter Bak, Daniel Souroujon, Edo Paz, Jon O Ebbert, Dan Zeltzer
OBJECTIVE: To evaluate the clinical outcomes of a remote mental health program for managing anxiety and depression, primarily using asynchronous digital communication. METHODS: This retrospective cohort study examined U.S. adults seeking remote care for anxiety and depression from January 2021 to May 2022. The program involves clinician-led assessment, patient education, medication management, and ongoing monitoring, primarily via text. Anxiety and depression were measured using Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) scores...
March 14, 2024: Journal of Telemedicine and Telecare
https://read.qxmd.com/read/38483265/the-effects-of-repetitive-head-impact-exposure-on-mental-health-symptoms-following-traumatic-brain-injury
#14
JOURNAL ARTICLE
Nicola L de Souza, Jennifer Bogner, John D Corrigan, Amanda R Rabinowitz, William C Walker, Raj G Kumar, Kristen Dams-O'Connor
OBJECTIVE: This study aimed to characterize the types and timing of repetitive head impact (RHI) exposures in individuals with moderate to severe traumatic brain injury (TBI) and to examine the effects of RHI exposures on mental health outcomes. SETTING: TBI Model Systems National Database. PARTICIPANTS: 447 patients with moderate to severe TBI who reported RHI exposure between 2015 and 2022. DESIGN: Secondary data analysis...
March 14, 2024: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/38483149/neuronal-antibodies-in-nonparaneoplastic-autoimmune-cerebellar-ataxias
#15
JOURNAL ARTICLE
Albert Saiz, Francesc Graus
PURPOSE OF REVIEW: To describe relevant advances in nonparaneoplastic autoimmune cerebellar ataxias (ACA) with neuronal antibodies. RECENT FINDINGS: Apart from metabotropic glutamate receptor 1(mGluR1) antibodies, in recent years, the number of neuronal antibodies against surface antigens in ACA has increased with the description of glutamate kainate receptor subunit 2 (GluK2) antibodies in young patients with cerebellitis. Around 20% of patients with contactin-associated protein-like 2 (CASPR2) encephalitis also present prominent cerebellar ataxia...
March 15, 2024: Current Opinion in Neurology
https://read.qxmd.com/read/38483005/comparing-eating-disorder-treatment-outcomes-of-transgender-and-gender-diverse-adolescents-with-those-of-cisgender-adolescents
#16
JOURNAL ARTICLE
Megan Riddle, Dan V Blalock, Lee Robertson, Alan Duffy, Daniel Le Grange, Philip S Mehler, Renee D Rienecke, Thomas Joiner
OBJECTIVE: Eating disorder (ED), depression, and anxiety symptoms at admission and discharge were compared, as were admission-to-discharge changes, for transgender and gender diverse (TGD), and cisgender adolescents receiving intensive treatment for EDs. METHOD: Participants were 44 TGD and 573 cisgender adolescents admitted to a treatment facility. Participants completed the Eating Disorder Examination Questionnaire (EDE-Q), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) at admission and discharge...
March 14, 2024: International Journal of Eating Disorders
https://read.qxmd.com/read/38482299/psychological-impact-of-covid-19-lockdown-period-on-students-of-healthcare-colleges
#17
JOURNAL ARTICLE
Haya Alayadi, Arwa Talakey, Omar Alsadon, Sajith Vellappally, Sachin Naik
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic globally caused depression, anxiety, and post-traumatic stress. Mental health was affected by social separation, curfews, school and business closures, economic deterioration, and government objectives. This study intends to assess the influence of the post-COVID-19 lockdown period on the psychological health of students enrolled in health colleges at King Saud University, Saudi Arabia. MATERIALS AND METHODS: A cross-sectional study was conducted among students of healthcare colleges at King Saud University...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38479840/adnp-modulates-sine-b2-derived-ctcf-binding-sites-during-blastocyst-formation-in-mice
#18
JOURNAL ARTICLE
Wen Wang, Rui Gao, Dongxu Yang, Mingli Ma, Ruge Zang, Xiangxiu Wang, Chuan Chen, Xiaochen Kou, Yanhong Zhao, Jiayu Chen, Xuelian Liu, Jiaxu Lu, Ben Xu, Juntao Liu, Yanxin Huang, Chaoqun Chen, Hong Wang, Shaorong Gao, Yong Zhang, Yawei Gao
CTCF is crucial for chromatin structure and transcription regulation in early embryonic development. However, the kinetics of CTCF chromatin occupation in preimplantation embryos have remained unclear. In this study, we used CUT&RUN technology to investigate CTCF occupancy in mouse preimplantation development. Our findings revealed that CTCF begins binding to the genome prior to zygotic genome activation (ZGA), with a preference for CTCF-anchored chromatin loops. Although the majority of CTCF occupancy is consistently maintained, we identified a specific set of binding sites enriched in the mouse-specific short interspersed element (SINE) family B2 that are restricted to the cleavage stages...
March 13, 2024: Genes & Development
https://read.qxmd.com/read/38479839/coordination-of-histone-chaperones-for-parental-histone-segregation-and-epigenetic-inheritance
#19
JOURNAL ARTICLE
Yimeng Fang, Xu Hua, Chun-Min Shan, Takenori Toda, Feng Qiao, Zhiguo Zhang, Songtao Jia
Chromatin-based epigenetic memory relies on the accurate distribution of parental histone H3-H4 tetramers to newly replicated DNA strands. Mcm2, a subunit of the replicative helicase, and Dpb3/4, subunits of DNA polymerase ε, govern parental histone H3-H4 deposition to the lagging and leading strands, respectively. However, their contribution to epigenetic inheritance remains controversial. Here, using fission yeast heterochromatin inheritance systems that eliminate interference from initiation pathways, we show that a Mcm2 histone binding mutation severely disrupts heterochromatin inheritance, while mutations in Dpb3/4 cause only moderate defects...
March 13, 2024: Genes & Development
https://read.qxmd.com/read/38479517/shared-and-distinct-prefrontal-cortex-alterations-of-implicit-emotion-regulation-in-depression-and-anxiety-an-fnirs-investigation
#20
JOURNAL ARTICLE
Hai-Yang Wang, Hui-Li You, Chun-Li Song, Lu Zhou, Shi-Yao Wang, Xue-Lin Li, Zhan-Hua Liang, Bing-Wei Zhang
BACKGROUND: Emotion regulation deficits, particularly in cognitive reappraisal, are crucial in depression and anxiety. However, research on the neural mechanisms of implicit emotion regulation is lacking, and it remains unclear whether these mechanisms are shared or distinct between the two disorders. METHODS: We investigated the neural mechanisms of implicit cognitive reappraisal in 28 individuals with major depressive disorder (MDD), 25 with generalized anxiety disorder (GAD), and 30 healthy controls (HC) using functional near-infrared spectroscopy (fNIRS)...
March 11, 2024: Journal of Affective Disorders
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