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clinical Neuropsychology

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https://www.readbyqxmd.com/read/29683228/relationships-between-self-reported-sleep-quality-components-and-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-following-chemotherapy
#1
Ashley M Henneghan, Patricia Carter, Alexa Stuifbergan, Brennan Parmelee, Shelli Kesler
OBJECTIVE: Links have been made between aspects of sleep quality and cognitive function in breast cancer survivors (BCS), but findings are heterogeneous. The objective of this study is to examine relationships between specific sleep quality components (latency, duration, efficiency, daytime sleepiness, sleep disturbance, use of sleep aids) and cognitive impairment (performance and perceived), and determine which sleep quality components are the most significant contributors to cognitive impairments in BCS 6 months to 10 years post chemotherapy...
April 23, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29683061/autistic-traits-and-neuropsychological-performance-in-6-to-10-year-old-children-a-population-based-study
#2
Fjola Hyseni, Laura M E Blanken, Ryan Muetzel, Frank C Verhulst, Henning Tiemeier, Tonya White
Clinical studies of children with autism spectrum disorder (ASD) provide evidence for poorer neuropsychological performance within specific domains compared to age, gender, and sometimes IQ-matched controls. Since recent evidence suggests that autistic symptoms form a spectrum that extends into the general population, it was our goal to evaluate the nature of the relationship between autistic traits and neuropsychological performance across the continuum in the general population. We examined neuropsychological performance across five different domains in 1019 6-to-10-year-old children participating in a population-based study of child development...
April 23, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29682239/diagnostic-relevance-of-spatial-orientation-for-vascular-dementia-a-case-study
#3
Gillian Coughlan, Emma Flanagan, Stephen Jeffs, Maxime Bertoux, Hugo Spiers, Eneida Mioshi, Michael Hornberger
Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer's disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case. Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29682234/performance-of-the-pentagon-drawing-test-for-the-screening-of-older-adults-with-alzheimer-s-dementia
#4
José Eduardo Martinelli, Juliana Francisca Cecato, Marcos Oliveira Martinelli, Brian Alvarez Ribeiro de Melo, Ivan Aprahamian
The Pentagon Drawing Test (PDT) is a common cognitive screening test. Objective: The aim of this study was to evaluate performance properties of a specific PDT scoring scale in older adults with Alzheimer's disease (AD) and healthy controls. Methods: A cross-sectional study of 390 elderly patients, aged 60 years or older with at least two years of education was conducted. All participants completed clinical and neuropsychological evaluations, including the Cambridge Cognitive Examination, the Mini-Mental State Examination (MMSE), and the Clock Drawing Test...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29682229/cognitive-deficits-in-older-adults-with-mild-cognitive-impairment-in-a-two-year-follow-up-study
#5
Camila de Assis Faria, Heloisa Veiga Dias Alves, Eduarda Naidel Barboza E Barbosa, Helenice Charchat-Fichman
Characterizing cognitive decline in older adults with MCI over time is important to identify the cognitive profile of those who convert to dementia. Objective: This study examined the two-year cognitive trajectory of elderly adults diagnosed with MCI, from geriatrics and neurology outpatient clinics of a public hospital in Rio de Janeiro. Methods: 62 older adults with MCI were submitted to a neuropsychological battery and re-evaluated after two years. The Mann-Whitney U test was employed to assess differences between groups with respect to education, functioning, the Geriatric Depression Scale and diagnosis...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29679991/empirical-evidence-for-discrete-neurocognitive-subgroups-in-patients-with-non-psychotic-major-depressive-disorder-clinical-implications
#6
Shenghong Pu, Takamasa Noda, Shiori Setoyama, Kazuyuki Nakagome
BACKGROUND: Neuropsychological deficits are present across various cognitive domains in major depressive disorder (MDD). However, a consistent and specific profile of neuropsychological abnormalities has not yet been established. METHODS: We assessed cognition in 170 patients with non-psychotic MDD using the Brief Assessment of Cognition in Schizophrenia and the scores were compared with those of 42 patients with schizophrenia as a reference for severity of cognitive impairment...
April 22, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29679576/quantitative-appraisal-of-the-amyloid-imaging-taskforce-appropriate-use-criteria-for-amyloid-pet
#7
Daniele Altomare, Clarissa Ferrari, Cristina Festari, Ugo Paolo Guerra, Cristina Muscio, Alessandro Padovani, Giovanni B Frisoni, Marina Boccardi
INTRODUCTION: We test the hypothesis that amyloid-PET prescriptions, considered appropriate based on the Amyloid Imaging Taskforce (AIT) criteria, lead to greater clinical utility than AIT-inappropriate prescriptions. METHODS: We compared the clinical utility between patients who underwent amyloid-PET appropriately or inappropriately and among the subgroups of patients defined by the AIT criteria. Finally, we performed logistic regressions to identify variables associated with clinical utility...
April 18, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29678679/formal-thought-disorders-from-phenomenology-to-neurobiology
#8
REVIEW
Tilo Kircher, Henrike Bröhl, Felicitas Meier, Jennifer Engelen
Formal thought disorder (FTD) is present in most psychiatric disorders and in some healthy individuals. In this Review, we present a comprehensive, integrative, and multilevel account of what is known about FTD, covering genetic, cellular, and neurotransmitter effects, environmental influences, experimental psychology and neuropsychology, brain imaging, phenomenology, linguistics, and treatment. FTD is a dimensional, phenomenologically defined construct, which can be clinically subdivided into positive versus negative and objective versus subjective symptom clusters...
April 17, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29676675/-i-m-just-forgetting-and-i-don-t-know-why-exploring-how-people-living-with-hiv-associated-neurocognitive-disorder-view-manage-and-obtain-support-for-their-cognitive-difficulties
#9
Alexander R Terpstra, Catherine Worthington, Francisco Ibáñez-Carrasco, Kelly K O'Brien, Aiko Yamamoto, Soo Chan Carusone, Rosalind Baltzer Turje, Patrick McDougall, William Granger, Victor Thompson, Maureen DeSousa, Liz Creal, Allan Rae, Claudia Medina, Elizabeth Morley, Sean B Rourke
HIV-associated neurocognitive disorder (HAND) is common, but the lived experience of HAND is not well-understood. In this descriptive qualitative study, we explored how adults with HAND view, manage, and obtain support for cognitive difficulties. We interviewed 25 participants (20% female; median age = 51 years) who were diagnosed with HAND using neuropsychological assessment and a clinical interview. Semistructured interviews, co-developed with community members living with HIV, focused on how cognitive difficulties manifested and progressed, impacted well-being, and were discussed with others...
May 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29672930/clinical-and-imaging-correlates-of-amyloid-deposition-in-dementia-with-lewy-bodies
#10
Paul C Donaghy, Michael J Firbank, Alan J Thomas, Jim Lloyd, George Petrides, Nicola Barnett, Kirsty Olsen, John T O'Brien
BACKGROUND: Amyloid deposition is common in dementia with Lewy bodies, but its pathophysiological significance is unclear. OBJECTIVE: The objective of this study was to investigate the relationship between amyloid deposition and clinical profile, gray matter volume, and brain perfusion in dementia with Lewy bodies. METHODS: Dementia with Lewy bodies (n = 37), Alzheimer's disease (n = 20), and controls (n = 20) underwent a thorough clinical assessment, 3T MRI, and early- and late-phase 18 F-Florbetapir PET-CT to assess cortical perfusion and amyloid deposition, respectively...
April 19, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29672757/time-for-a-quick-word-the-striking-benefits-of-training-speed-and-accuracy-of-word-retrieval-in-post-stroke-aphasia
#11
Paul Conroy, Christina Sotiropoulou Drosopoulou, Gina F Humphreys, Ajay D Halai, Matthew A Lambon Ralph
One-third of stroke survivors experience deficits in word retrieval as a core characteristic of their aphasia, which is frustrating, socially limiting and disabling for their professional and everyday lives. The, as yet, undiscovered 'holy grail' of clinical practice is to establish a treatment that not only improves item naming, but also generalizes to patients' connected speech. Speech production in healthy participants is a remarkable feat of cognitive processing being both rapid (at least 120 words per minute) and accurate (∼one error per 1000 words)...
April 17, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29672517/white-matter-alterations-in-the-internal-capsule-and-psychomotor-impairment-in-melancholic-depression
#12
Matthew P Hyett, Alistair Perry, Michael Breakspear, Wei Wen, Gordon B Parker
Emerging evidence suggests that structural brain abnormalities may play a role in the pathophysiology of melancholic depression. We set out to test whether diffusion-derived estimates of white matter structure were disrupted in melancholia in regions underpinning psychomotor function. We hypothesized that those with melancholia (and evidencing impaired psychomotor function) would show disrupted white matter organization in internal capsule subdivisions. Diffusion magnetic resonance imaging (dMRI) data were acquired from 22 melancholic depressed, 23 non-melancholic depressed, and 29 healthy control participants...
2018: PloS One
https://www.readbyqxmd.com/read/29669906/cortical-and-subcortical-gray-matter-bases-of-cognitive-deficits-in-rem-sleep-behavior-disorder
#13
Shady Rahayel, Ronald B Postuma, Jacques Montplaisir, Daphné Génier Marchand, Frédérique Escudier, Malo Gaubert, Pierre-Alexandre Bourgouin, Julie Carrier, Oury Monchi, Sven Joubert, Frédéric Blanc, Jean-François Gagnon
OBJECTIVE: To investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI). METHODS: Fifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3-tesla MRI acquisition of T1 anatomical images...
April 18, 2018: Neurology
https://www.readbyqxmd.com/read/29669609/neuropsychological-test-performance-in-parkinsonism-without-dopaminergic-deficiency-on-123i-fp-cit-spect-imaging
#14
Kathryn A Wyman-Chick, Phillip K Martin, Michal Minár, Manuel Menéndez-González, Lauren O Erickson, Tania Álvarez-Avellón, Ryan W Schroeder
OBJECTIVES: To examine neuropsychological test performance among individuals clinically diagnosed with Parkinson's disease (PD) without evidence of dopaminergic deficiency on [123]I-CIT single photon emission computed tomography imaging. METHODS: Data were obtained from the Parkinson's Progression Marker Initiative. The sample included 59 participants with scans without evidence of dopaminergic deficiency (SWEDD), 412 with PD, and 114 healthy controls (HC). Tests included Judgment of Line Orientation, Letter-Number Sequencing, Symbol Digit Modalities, Hopkins Verbal Learning Test-Revised, and Letter and Category Fluency...
April 19, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29669557/discovery-biology-of-neuropsychiatric-syndromes-dbns-a-center-for-integrating-clinical-medicine-and-basic-science
#15
Biju Viswanath, Naren P Rao, Janardhanan C Narayanaswamy, Palanimuthu T Sivakumar, Arun Kandasamy, Muralidharan Kesavan, Urvakhsh Meherwan Mehta, Ganesan Venkatasubramanian, John P John, Odity Mukherjee, Meera Purushottam, Ramakrishnan Kannan, Bhupesh Mehta, Thennarasu Kandavel, B Binukumar, Jitender Saini, Deepak Jayarajan, A Shyamsundar, Sydney Moirangthem, K G Vijay Kumar, Jagadisha Thirthalli, Prabha S Chandra, Bangalore N Gangadhar, Pratima Murthy, Mitradas M Panicker, Upinder S Bhalla, Sumantra Chattarji, Vivek Benegal, Mathew Varghese, Janardhan Y C Reddy, Padinjat Raghu, Mahendra Rao, Sanjeev Jain
BACKGROUND: There is emerging evidence that there are shared genetic, environmental and developmental risk factors in psychiatry, that cut across traditional diagnostic boundaries. With this background, the Discovery biology of neuropsychiatric syndromes (DBNS) proposes to recruit patients from five different syndromes (schizophrenia, bipolar disorder, obsessive compulsive disorder, Alzheimer's dementia and substance use disorders), identify those with multiple affected relatives, and invite these families to participate in this study...
April 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29669461/connected-speech-and-language-in-mild-cognitive-impairment-and-alzheimer-s-disease-a-review-of-picture-description-tasks
#16
Kimberly D Mueller, Bruce Hermann, Jonilda Mecollari, Lyn S Turkstra
INTRODUCTION: The neuropsychological profile of people with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia includes a history of decline in memory and other cognitive domains, including language. While language impairments have been well described in AD dementia, language features of MCI are less well understood. Connected speech and language analysis is the study of an individual's spoken discourse, usually elicited by a target stimulus, the results of which can facilitate understanding of how language deficits typical of MCI and AD dementia manifest in everyday communication...
April 19, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29667564/the-recency-ratio-as-predictor-of-early-mci
#17
Davide Bruno, Rebecca L Koscik, John L Woodard, Nunzio Pomara, Sterling C Johnson
ABSTRACTObjectives:Individuals with Alzheimer's disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. (Journal of Clinical and Experimental Neuropsychology, Vol. 38, 2016, pp. 967-973) have shown that higher ratio scores between immediate and delayed recency (i.e. the recency ratio; Rr) are associated with cognitive decline in high-functioning older individuals. We tested whether Rr predicted conversion to early mild cognitive impairment (early MCI) from a cognitively healthy baseline...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667540/16th-annual-aacn-conference-and-workshops-of-the-american-academy-of-clinical-neuropsychology-aacn-at-the-san-diego-marriott-marquis-marina-333-w-harbor-dr-san-diego-ca-june-20-23-2018
#18
https://www.readbyqxmd.com/read/29667473/harnessing-neuroplasticity-modern-approaches-and-clinical-future
#19
Andrew Octavian Sasmita, Joshua Kuruvilla, Anna Pick Kiong Ling
Neurological diseases and injuries to the nervous system may cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would catastrophically accumulate, leading to the development of neurological and neurodegenerative disorders which might affect memory, cognition, and motoric functions. The body has various negative feedback systems which are able to induce beneficial neuroplastic changes in mediating some neuronal damage, however, such efforts are often not enough to ameliorate the derogatory changes...
April 18, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29665875/global-cerebrovascular-burden-and-long-term-clinical-outcomes-in-asian-elderly-across-the-spectrum-of-cognitive-impairment
#20
Xin Xu, Yiong Huak Chan, Qun Lin Chan, Bibek Gyanwali, Saima Hilal, Boon Yeow Tan, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen
ABSTRACTBackground/Aim:To investigate the predictive ability of the previously established global cerebrovascular disease (CeVD) burden scale on long-term clinical outcomes in a longitudinal study of Asian elderly participants across the spectrum of cognitive impairment. METHODS: A case-control study was conducted over a 2-year period involving participants with no cognitive impairment, cognitive impairment-no dementia (CIND), and Alzheimer's disease (AD). Annually, cognitive function was assessed with a comprehensive neuropsychological battery and the clinical dementia rating (CDR) scale was used to stage disease severity...
April 18, 2018: International Psychogeriatrics
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