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Thyroid cancer, thyroid nodules

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https://www.readbyqxmd.com/read/29666959/carney-complex-a-case-with-thyroid-follicular-adenoma-without-a-prkar1a-mutation
#1
Shinji Hattori, Yukou Yamane, Ryoichi Shimomura, Yuki Uchida, Nobuhiko Toyota, Yoshio Miura, Setsujyo Shiota, Yoshitsugu Tajima
BACKGROUND: Carney complex (CNC) is a very rare disease. Although thyroid lesions are included in the diagnostic criteria for CNC, they are an infrequent occurrence. CASE PRESENTATION: The patient was a 69-year-old woman who had undergone the removal of a left atrial myxoma 10 years earlier, at the age of 59. At the time of the operation, thyroid ultrasonography (US) revealed multiple hypoechoic nodules. Thyroid scintigraphy revealed an increased uptake of 99m Tc in these lesions, which was consistent with toxic multinodular goiter, and she was diagnosed with CNC...
April 17, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29665745/heterogeneity-in-ppv-of-ras-mutations-in-cytologically-indeterminate-thyroid-nodules
#2
Fadi Nabhan, Kyle Porter, Mark Lupo, Gregory W Randolph, Kepal Narendra Patel, Richard T Kloos
BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown and it causes clinical management uncertainty. We performed a systematic review evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules and considered variables that might affect residual heterogeneity across the different studies...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29664842/incidental-thoracic-findings-on-routine-computed-tomography-in-epithelial-ovarian-cancer
#3
Bobby D OʼLeary, Teresa Treacy, Tony Geoghegan, Tom A Walsh, William D Boyd, Donal J Brennan
INTRODUCTION: Multidetector computed tomography (MDCT) is routinely used in the surveillance of epithelial ovarian cancer. The aim of this study was to determine the incidence of thoracic findings on routine MDCT surveillance imaging in patients with ovarian carcinoma. MATERIALS AND METHODS: Retrospective evaluation of 100 MDCT studies of patients with a diagnosis of epithelial ovarian cancer was performed at a university teaching hospital. The cross-sectional studies were reviewed by a consultant radiologist with subspeciality training in cross-sectional imaging...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29662564/dual-pathologies-of-parathyroid-adenoma-and-papillary-thyroid-cancer-on-fluorocholine-and-fluorodeoxyglucose-pet-ct
#4
N T K Thanseer, Sanjay Kumar Bhadada, Ashwani Sood, Ashwin Singh Parihar, Divya Dahiya, Priyanka Singh, Rajender Kumar Basher, Ashim Das, Bhagwant R Mittal
18 F-Fluorocholine (FCH) PET/CT is evolving as a functional imaging modality for the preoperative imaging of abnormal parathyroid tissue(s) helping to localize eutopic and ectopic parathyroid tissue and limit the extent of surgery. FCH PET/CT may show incidental uptake in various thyroid lesions necessitating further evaluation, whereas the role of 18 F-fluorodeoxyglucose (FDG) PET/CT in the detection of incidental thyroid nodules is well documented. The case of a middle-aged woman with dual pathology of parathyroid adenoma and papillary thyroid cancer detected on FCH and FDG PET/CT is presented...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662266/thyroid-nodules-and-long-term-follow-up-among-childhood-cancer-survivors-who-underwent-hematopoietic-stem-cell-transplantation
#5
Shunsuke Shimazaki, Itsuro Kazukawa, Maine Ishida, Masanori Minagawa
Thyroid nodules have been observed in childhood cancer survivors (CCS) treated with chemotherapy and radiotherapy. We report four patients with thyroid nodules identified during the long-term follow-up of children who underwent hematopoietic stem cell transplantation (HSCT). The thyroid nodules were diagnosed as adenomatous goiter in all four patients. The interval between the primary cancer diagnosis and the occurrence of the thyroid nodules was more than 10 yr. Furthermore, all four patients underwent HSCT in conditioning with total body irradiation (TBI) before the age of 10 yr...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29649016/thyroid-cancer-management-from-a-suspicious-nodule-to-targeted-therapy
#6
Francesco Perri, Antonio Giordano, Salvatore Pisconti, Franco Ionna, Maria G Chiofalo, Francesco Longo, Davide Leopardo, Giuseppina Della Vittoria Scarpati, Luciano Pezzullo
Thyroid nodules are very common, and their frequency is four to five times higher in women than in men. Most of them are benign, with only a very little percentage revealing a malignant neoplasm. About 50% of thyroid nodules are detected by self-palpation of neck, whereas the other 50% are diagnosed by neck ultrasonography and following fine-needle aspiration. Management of thyroid nodules is very difficult, because benign nodules are prevalent, whereas thyroid carcinoma is uncommon, representing only 1% of all malignancies...
April 11, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#7
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29626249/molecular-markers-in-well-differentiated-thyroid-cancer
#8
REVIEW
Anil K D'Cruz, Richa Vaish, Abhishek Vaidya, Iain J Nixon, Michelle D Williams, Vincent Vander Poorten, Fernando López, Peter Angelos, Ashok R Shaha, Avi Khafif, Alena Skalova, Alessandra Rinaldo, Jennifer L Hunt, Alfio Ferlito
PURPOSE: Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. This review covers the fundamental role of the signaling pathways and genetic changes involved in thyroid carcinogenesis. The current literature on the prognostic significance of these markers is also described...
April 6, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29624786/impact-of-oncogene-panel-results-on-surgical-management-of-cytologically-indeterminate-thyroid-nodules
#9
Pablo Valderrabano, Laila Khazai, Zachary J Thompson, Marino E Leon, Kristen J Otto, Julie E Hallanger-Johnson, J Trad Wadsworth, Christine H Chung, Barbara A Centeno, Bryan McIver
BACKGROUND: The impact of oncogene panel results on the surgical management of indeterminate thyroid nodules (ITNs) is currently unknown. METHODS: Surgical management of 649 patients consecutively evaluated from October 2008 to April 2016 with a single nodule biopsied and indeterminate cytology (193 evaluated with and 456 without oncogene panels) was assessed and compared. Histological features of 629 consecutively resected ITNs (164 evaluated with and 465 without oncogene panels) were also characterized and compared...
April 6, 2018: Head & Neck
https://www.readbyqxmd.com/read/29610391/application-of-genomics-to-identify-therapeutic-targets-in-recurrent-pediatric-papillary-thyroid-carcinoma
#10
Rebecca Ronsley, S Rod Rassekh, Yaoqing Shen, Anna F Lee, Colleen Jantzen, Jessica Halparin, Catherine Albert, Douglas S Hawkins, Shazhan Amed, Ralph Rothstein, Andrew J Mungall, David Dix, Geoffrey Blair, Helen Nadel, Steven J M Jones, Janessa Laskin, Marco A Marra, Rebecca J Deyell
Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA thyroid cancer compendium and to Illumina BodyMap normal thyroid. This patient demonstrated resolution of multiple pulmonary nodules without toxicity on oral TRK inhibitor therapy. A RET fusion was identified in the second tumor, another potentially actionable finding...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29608439/quantitative-analysis-of-the-benefits-and-risk-of-thyroid-nodule-evaluation-in-patients-%C3%A2-70-years-old
#11
Zhihong Wang, Chirag M Vyas, Olivia Van Benschoten, Matt A Nehs, Francis D Moore, Ellen Marqusee, Jeffrey F Krane, Matthew I Kim, Howard T Heller, Atul A Gawande, Mary C Frates, Peter M Doubilet, Gerard M Doherty, Nancy L Cho, Edmund S Cibas, Carol B Benson, Justine A Barletta, Ann Marie Zavacki, P Reed Larsen, Erik K Alexander, Trevor E Angell
BACKGROUND: In older patients, thyroid nodules are frequently detected and referred for evaluation, though usually prove to be benign disease or low-risk cancer. Therefore, management should be guided not solely by malignancy risk, but also by the relative risks of any intervention. Unfortunately, few such data are available for patients ≥70 years old. METHODS: All consecutive patients ≥70 years old assessed by ultrasound (US) and fine-needle aspiration (FNA) between 1995 and 2015 were analyzed...
April 2, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29603332/solid-papillary-breast-carcinomas-resembling-the-tall-cell-variant-of-papillary-thyroid-neoplasms-solid-papillary-carcinomas-with-reverse-polarity-harbor-recurrent-mutations-affecting-idh2-and-pik3ca-a-validation-cohort
#12
John R Lozada, Thais Basili, Fresia Pareja, Barbara Alemar, Arnaud C Paula, Rodrigo Gularte-Merida, Dilip D Giri, Patrizia Querzoli, Gabor Cserni, Emad A Rakha, Maria Pia Foschini, Jorge S Reis-Filho, Edi Brogi, Britta Weigelt, Felipe C Geyer
AIMS: Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histologic type of breast cancer that morphologically resembles the tall cell variant of papillary thyroid carcinoma. BPTCs are characterized by IDH2 R172 hotspot somatic mutations or mutually exclusive TET2 somatic mutations, concurrently with mutations affecting PI3K pathway-related genes. We sought to characterize their histology, and investigate the frequency of IDH2 and PIK3CA mutations in an independent cohort of BPTCs, as well as in conventional solid papillary carcinomas (SPCs)...
March 30, 2018: Histopathology
https://www.readbyqxmd.com/read/29595320/thyroid-nodules-and-cancer-in-children-and-adolescents-affected-by-hashimoto-s-thyroiditis
#13
Ji-Hye Won, Ji Ye Lee, Hyun Sook Hong, Sun Hye Jeong
OBJECTIVES: To investigate the rates of thyroid nodules and cancer in pediatric cases of Hashimoto's thyroiditis (HT) in Korea. METHODS: We retrospectively reviewed 89 pediatric and adolescent patients (age, 3-18.0 years) with HT who underwent thyroid ultrasonography (US) at our institution from February 2006 to July 2016. The diagnosis of HT was based on the presence of thyroid autoantibodies. The presence of any thyroid nodules with US and cytopathologic features was analyzed...
March 29, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29594062/liposarcoma-of-the-thyroid-a-case-report-with-a-review-of-the-literature
#14
Vittoria Guarda, Anja Pickhard, Melanie Boxberg, Katja Specht, Anna Maria Stefanie Buchberger
Background: Liposarcomas of the thyroid gland are extremely rare tumors, and, to our knowledge, only 12 cases have been reported in the English literature. An accurate diagnosis is challenging due to the nonspecific clinical presentation of this cancer, frequently defined just by a swelling of the neck. Patient Findings: We present an 82-year-old woman with liposarcoma of the thyroid, complaining of a fast-growing neck mass. MRI and neck ultrasound showed a large lipomatous mass, which corresponded to a cold nodule in the thyroid scan...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29590402/benign-thyroid-diseases-and-risk-of-thyroid-cancer-a-nationwide-cohort-study
#15
Cari M Kitahara, Dóra K Rmendiné Farkas, Jens Otto L Jørgensen, Deirdre Cronin-Fenton, Henrik Toft Sørensen
Context: Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk. Objective: To examine thyroid cancer risk following diagnoses of a wide range of benign thyroid conditions. Design: Hospital and cancer registry linkage cohort study for the years 1978-2013. Setting: Nationwide (Denmark)...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29581701/thyroid-nodule-management-thyroid-stimulating-hormone-ultrasound-and-cytological-classification-system-for-predicting-malignancy
#16
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Mohammed A Thabet, Rim Braham
Background/objectives: Thyroid nodule (TN) is a common thyroid disorder globally, and the incidence has been increasing in recent decades. The objective of this study was to determine the contribution of thyroid-stimulating hormone (TSH), ultrasound (US), and cytological classification system for predicting malignancy among the surgically excised nodules. Design and methods: A retrospective analysis was performed between January 2012 and December 2014, using data drawn from 1188 patients (15-90 years), who had 1433 TN and fine-needle aspiration in Prince Sultan Military Medical City, Saudi Arabia...
2018: Cancer Informatics
https://www.readbyqxmd.com/read/29575028/ultrasound-and-the-evaluation-of-pediatric-thyroid-malignancy-current-recommendations-for-diagnosis-and-follow-up
#17
REVIEW
Sarah Ogle, Alexa Merz, Ralitza Parina, Mahmoud Alsayed, Mira Milas
Ultrasound (US) plays a critical role in the evaluation, treatment, screening, and surveillance of thyroid malignancy in pediatric patients. This review aims to summarize recent advances in this topic. Improvements in imaging technology have amplified the advantage of US and US-guided fine-needle aspiration biopsy for thyroid nodule evaluation, cancer diagnosis, and surgical planning. Ultrasound has a definitive screening role for early cancer detection in high-risk patients, including those with a history of radiation exposure from childhood treatments, environmental radiation disasters, or hereditary/familial cancer syndromes...
March 25, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29574528/microrna-expression-profile-of-thyroid-nodules-in-fine-needle-aspiration-cytology-a-confirmatory-series
#18
M G Castagna, C Marzocchi, T Pilli, R Forleo, F Pacini, S Cantara
INTRODUCTION: MiRNAs are small endogenous non-coding RNAs implicated with gene expression regulation. Changes in miRNA levels have been reported in thyroid cancer. Fine-needle aspiration cytology (FNAC) is the most reliable tool for differential diagnosis of thyroid nodules. METHODS: We have analyzed 174 FNAC from 168 patients with thyroid nodules for expression levels of 11 miRNAs (miRNA197; -187; -181b-3p; -181b-5p; -224; -181a; 146b; -221; -222; -155 and miRNA183) known to be up-regulated in cancer tissues compared to benign lesions...
March 24, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29571800/central-echogenic-areas-in-thyroid-nodules-diagnostic-performance-in-prediction-of-papillary-cancer
#19
Sean M Siebert, R Brooke Jeffrey, Adam J Gomez, Aya Kamaya
PURPOSE: To determine the diagnostic performance of the "central echogenic area" sonographic finding in differentiating papillary carcinomas from benign nodules and to how this finding may be used to improve fine needle aspiration(FNA) technique/utilization. MATERIALS AND METHODS: We retrospectively analyzed ultrasound guided FNAs of thyroid nodules between 1 and 3 cm for central echogenic areas. 92 patients (evenly distributed benign vs papillary carcinoma) were evaluated by a blinded reader for areas of non-shadowing homogenously echogenic centers within the nodules and correlated with FNA proven pathologic diagnosis...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29569123/predictivity-of-clinical-laboratory-and-imaging-findings-in-diagnostic-definition-of-palpable-thyroid-nodules-a-multicenter-prospective-study
#20
Maria Grazia Chiofalo, Simona Signoriello, Franco Fulciniti, Nicola Avenia, Serenella Ristagno, Celestino Pio Lombardi, Angelo Nicolosi, Maria Rosa Pelizzo, Giuliano Perigli, Andrea Polistena, Vincenzo Panebianco, Rocco Bellantone, Pietro Giorgio Calò, Isabella Merante Boschin, Benedetta Badii, Massimo Di Maio, Ciro Gallo, Francesco Perrone, Luciano Pezzullo
PURPOSE: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules. METHODS: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4-5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor...
March 22, 2018: Endocrine
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