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Thyroid cancer, thyroid nodules

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https://www.readbyqxmd.com/read/28640139/a-prisma-compliant-systematic-review-and-meta-analysis-of-the-relationship-between-thyroid-disease-and-different-levels-of-iodine-intake-in-mainland-china
#1
Wanwen Weng, Mengjie Dong, Jun Zhan, Jun Yang, Bo Zhang, Xingdong Zhao
BACKGROUND: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered. OBJECTIVE: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639967/ras-positive-thyroid-nodules
#2
Trevor E Angell
PURPOSE OF REVIEW: The current review focuses on the uncertainty regarding the management of rat sarcoma viral oncogene homolog RAS-positive thyroid nodules. The application of oncogene testing has been heralded for improving risk assessment for indeterminate cytology thyroid nodules and has grown in clinical use. RAS mutations are historically considered oncogenic. However, RAS mutation detection in thyroid nodules has proven problematic, as these mutations are found in benign and malignant lesions...
July 20, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28632145/what-really-is-an-indeterminate-fna-thyroid-nodule
#3
Angela Pezzolla, Serafina Lattarulo, Andrea Madaro, Giovanni Docimo, Emanuela Lacalendola, Francesco Prete, Rinaldo Marzaioli
BACKGROUND: Thyroid nodules are usually benign; however, 5 to 15% prove to be malignant. Fine-needle aspiration (FNA) has become the gold standard in the evaluation of thyroid nodules, especially in single nodule more than a centimeter and / or in smaller nodule with ultrasound characters of malignancy. METHODS: We evaluated retrospectively 179 patients with "undetermined" thyroid fine needle aspiration, undergoing surgery. We compared cytology and histology and we evaluated sex, age, the presence of thyroiditis and dimension of the indeterminate nodule as predictors of malignancy...
June 12, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28621914/distinguishing-parathyroid-and-thyroid-lesions-on-ultrasound-guided-fine-needle-aspiration-a-correlation-of-clinical-data-ancillary-studies-and-molecular-analysis
#4
Margaret Cho, Thaira Oweity, Tamar C Brandler, Karen Fried, Pascale Levine
BACKGROUND: Differentiating parathyroid and thyroid lesions can be challenging because of considerable morphologic overlap and anatomic proximity. Therefore, the authors sought to identify characteristic morphologic patterns and useful adjunct tests to distinguish these 2 entities. METHODS: A search was conducted in the study institution database for clinically indeterminate thyroid nodules from 2000 through 2016 with an emphasis on confirmed parathyroid nodules...
June 16, 2017: Cancer
https://www.readbyqxmd.com/read/28616852/ultrasonographic-prediction-of-highly-aggressive-telomerase-reverse-transcriptase-tert-promoter-mutated-papillary-thyroid-cancer
#5
Tae Hyuk Kim, Chang-Seok Ki, Soo Yeon Hahn, Young Lyun Oh, Hye Won Jang, Sun Wook Kim, Jae Hoon Chung, Jung Hee Shin
PURPOSE: Telomerase reverse transcriptase promoter mutations are found in highly aggressive thyroid malignancies. Our aim was to define the ultrasonographic features of telomerase reverse transcriptase promoter-mutated papillary thyroid cancer and to evaluate their predictive performances. METHODS: Ultrasonographic findings were reviewed for 185 patients with surgically confirmed papillary thyroid cancer between 1994 and 2004. Genomic DNA to identify telomerase reverse transcriptase promoter mutations was extracted from archived surgical specimens...
June 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28614008/the-role-of-electronic-feedback-loops-in-the-continuous-quality-improvement-of-thyroid-nodule-and-thyroid-cancer-care
#6
Mark L Urken, Gregory Randolph, Lisa Orloff, Bruce M Wenig, Rosalie Machado, Marcela Osorio, Martha Griffin, R Michael Tuttle
No abstract text is available yet for this article.
June 14, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28612287/methylation-markers-differentiate-thyroid-cancer-from-benign-nodules
#7
J K Stephen, K M Chen, J Merritt, D Chitale, G Divine, M J Worsham
PURPOSE: The incidence of thyroid cancer (TC) is increasing. Cytology by itself cannot distinguish TC from some benign nodules especially in certain subtypes of TC. Our immediate goal is to identify DNA methylation markers for early detection of TC and to molecularly differentiate TC subtypes from benign nodules. METHODS: Promoter methylation status of 21 candidate genes was examined on formalin-fixed paraffin-embedded tissue (FFPE) utilizing quantitative methylation-specific polymerase chain reaction (QMSP) in a retrospective cohort of 329 patients (56% white, 29% African American, 61% female) comprising 71 normal thyroid, 83 benign nodules [follicular adenomas (FA)], 90 follicular TC (FTC) and 85 papillary TC (PTC)...
June 13, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28609009/triage-of-the-indeterminate-thyroid-aspirate-what-are-the-options-for-the-practicing-cytopathologist
#8
Ayse M Onenerk, Marc P Pusztaszeri, Sule Canberk, William C Faquin
Fine-needle aspiration (FNA) plays a key role in the early evaluation of patients with thyroid nodules; however, from 15% to 30% of FNA specimens are cytologically indeterminate. Molecular testing has proven useful when applied to indeterminate thyroid FNAs, and its use has been endorsed in the American Thyroid Association guidelines. In addition to the noncommercial ("in-house") application of v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), rat sarcoma (RAS), rearranged in transformation/papillary thyroid carcinoma (RET/PTC), and peroxisome proliferator-activated receptor γ/paired box gene 8 (PPARγ/PAX8) testing, there are currently 3 commercially available molecular panels that vary in their relative reported performances, strengths, and limitations...
June 2017: Cancer
https://www.readbyqxmd.com/read/28605303/diagnostic-value-of-circulating-microrna-95-and-190-in-the-differential-diagnosis-of-thyroid-nodules-a-validation-study-in-1000-consecutive-patients
#9
Tania Pilli, Silvia Cantara, Carlotta Marzocchi, Sandro Cardinale, Chiara Santini, Gabriele Cevenini, Furio Pacini
BACKGROUND: It has recently been demonstrated that the combination of miRNA-190 and -95 (expressed as probability of malignant risk: pmiRNA) in the serum of Caucasian patients with thyroid nodular disease allows the identification of nodules at high risk of malignancy with great accuracy. The present study aimed to validate these results in a larger cohort of patients. MATERIALS AND METHODS: This study prospectively analyzed 1000 patients. Cytological diagnosis was available in 982/1000 (98...
June 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28599426/dynamic-monitoring-of-circulating-micrornas-as-a-predictive-biomarker-for-the-diagnosis-and-recurrence-of-papillary-thyroid-carcinoma
#10
Yanqing Zhang, Desheng Xu, Jiaqi Pan, Zhengkai Yang, Meijun Chen, Jun Han, Sijia Zhang, Lulu Sun, Hong Qiao
Circulating microRNAs (miRNAs/miRs) are considered to be potential biomarkers for numerous types of cancer. However, previous investigations into the expression of miRNAs in the serum of patients with papillary thyroid carcinoma (PTC) to predict diagnosis, prognosis and recurrence have reported conflicting results, and the role of miRNAs remains unclear. The present study dynamically assessed the circulating miRNA profile in patients with PTC and determined whether miRNAs in the serum could be used as biomarkers for the diagnosis, prognosis and recurrence of PTC...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28589181/reliability-of-fine-needle-aspiration-biopsy-in-large-thyroid-nodules
#11
Osman Bozbıyık, Şafak Öztürk, Mutlu Ünver, Varlık Erol, Ümit Bayol, Cengiz Aydın
OBJECTIVE: Fine needle aspiration biopsy provides one of the most important data that determines the treatment algorithm of thyroid nodules. Nevertheless, the reliability of fine needle aspiration biopsy is controversial in large nodules. The aim of this study was to evaluate the adequacy of fine needle aspiration biopsy in thyroid nodules that are four cm or greater. MATERIAL AND METHODS: We retrospectively examined 219 patients files who underwent thyroidectomy for thyroid nodules that were greater than four centimeter between May 2007 and December 2012...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28589087/nodular-thyroid-disease-and-thyroid-cancer-in-the-era-of-precision-medicine
#12
REVIEW
Carles Zafon, Juan J Díez, Juan C Galofré, David S Cooper
The management of thyroid nodules, one of the main clinical challenges in endocrine clinical practice, is usually straightforward. Although the most important concern is ruling out malignancy, there are grey areas where uncertainty is frequently present: the nodules labelled as indeterminate by cytology and the extent of therapy when thyroid cancer is diagnosed pathologically. There is evidence that the current available precision medicine tools (from all the "-omics" to molecular analysis, fine-tuning imaging or artificial intelligence) may help to fill present gaps in the future...
April 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28581673/the-role-of-thyroid-fna-cytology-in-pediatric-malignant-lesions-an-overview-of-the-literature
#13
REVIEW
Esther Diana Rossi, Maurizio Martini, Tonia Cenci, Sara Capodimonti, Luigi Maria Larocca
When one is dealing with pediatric thyroid lesions, fine-needle aspiration is the first diagnostic tool for the correct characterization of these nodules. Despite the apparent infrequency of thyroid cancers in children, recent data from the National Cancer Institute prove that the incidence has been increasing, especially in adolescents. With the same data, a higher prevalence of well-differentiated cancers can be estimated, with 90% diagnosed as papillary thyroid cancer. Nonetheless, some publications have demonstrated that some specific malignant variants are more frequent in children and have a more aggressive behavior that justifies the increased number of surgical procedures...
June 5, 2017: Cancer
https://www.readbyqxmd.com/read/28571792/papillary-carcinoma-of-the-thyroid-in-patients-with-primary-hyperparathyroidism-is-there-a-link
#14
M Beebeejaun, E Chinnasamy, P Wilson, A Sharma, N Beharry, G Bano
Primary hyperparathyroidism (PHPT) is present in up to 0.1% of the general population. The incidence is higher in women and increases with age. The majority of the cases is asymptomatic and up to 85% are due to single gland adenoma. Parathyroidectomy is the treatment of choice after localization of the hyperactive gland. Papillary Thyroid Carcinoma (PTC) is the most common cancer of the thyroid and constitutes more than 70% of thyroid malignancies. PTC can present as a single nodule or can be Multifocal. The incidence is higher in women...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28567290/acth-secreting-medullary-thyroid-cancer-a-case-series
#15
Ayanthi A Wijewardene, Sarah J Glastras, Diana L Learoyd, Bruce G Robinson, Venessa H M Tsang
Medullary thyroid cancer (MTC) is a rare neuroendocrine tumour that originates from the parafollicular cells of the thyroid gland. The most common presentation of MTC is with a single nodule; however, by the time of diagnosis, most have spread to the surrounding cervical lymph nodes. Cushing's syndrome is a rare complication of MTC and is due to ectopic adrenocorticotrophic hormone (ACTH) secretion by tumour cells. Cushing's syndrome presents a challenging diagnostic and management issue in patients with MTC...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28565997/safety-of-radiofrequency-ablation-of-benign-thyroid-nodules-and-recurrent-thyroid-cancers-a-systematic-review-and-meta-analysis
#16
Sae Rom Chung, Chong Hyun Suh, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
OBJECTIVE: We performed a systematic review and meta-analysis to evaluate the safety of radiofrequency ablation (RFA) for the treatment of benign thyroid nodules and recurrent thyroid cancers. MATERIALS AND METHODS: Ovid-MEDLINE, EMBASE, and Library of Cochrane databases were searched up to July 12, 2016 for studies on the safety of RFA for treating benign thyroid nodules or recurrent thyroid cancers. Pooled proportions of overall and major complications were assessed using random-effects modeling...
June 1, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28545338/radiofrequency-ablation-of-small-follicular-neoplasms-initial-clinical-outcomes
#17
Su Min Ha, Jin Yong Sung, Jung Hwan Baek, Dong Gyu Na, Ji-Hoon Kim, Hyunju Yoo, Ducky Lee, Dong Whan Choi
BACKGROUND: In thyroid gland, radiofrequency ablation (RFA) has been applied to both recurrent cancers and benign nodules, although, according to the American Thyroid Association (ATA) and the Korean Society of Thyroid Radiology (KSThR) guidelines, surgery is the first-line treatment for follicular neoplasm. However, it has been argued that follicular neoplasm with lower risk of malignancy can be managed by close follow-up. In this study, we evaluated the effectiveness of RFA of small follicular neoplasms, examining reductions in volume and related clinical problems, and making observations over long-term follow-up...
May 25, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28544601/the-impact-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-on-the-performance-of-the-afirma-gene-expression-classifier
#18
Jen-Fan Hang, William H Westra, David S Cooper, Syed Z Ali
BACKGROUND: A recent revision in thyroid tumor nomenclature has resulted in a change from a malignant diagnosis (noninvasive follicular variant of papillary thyroid carcinoma) to one that is nonmalignant (noninvasive follicular thyroid neoplasm with papillary-like nuclear features [NIFTP]). The objective of the current study was to evaluate the impact of this change on the performance of the Afirma gene expression classifier (GEC). METHODS: The authors retrospectively analyzed consecutive thyroid fine-needle aspiration specimens with indeterminate diagnoses on which GEC was performed...
May 24, 2017: Cancer
https://www.readbyqxmd.com/read/28544576/atypical-adenoma-of-the-thyroid-diagnosed-as-anaplastic-cancer-by-cytopathology
#19
Hiromitsu Hatakeyama, Kimiko Hoshino, Kenji Mizoguchi, Takayoshi Suzuki, Kanako C Hatanaka, Yukie Yamaya, Satoshi Kano, Takatsugu Mizumachi, Akihiro Homma
Atypical adenoma of the thyroid is a rare form of tumor, and its accurate diagnosis prior to surgical resection is difficult as the histological and pathological morphologies are very similar to those of anaplastic thyroid carcinoma (ATC), and its anaplastic transformation remains to be elucidated. We reported a case of a 75-year-old female with a thyroid isthmus nodule diagnosed repeatedly by FNAC as anaplastic carcinoma. Both the first and second FNAC specimen slides showed a large number of scattered or aggregated atypical cells consisting of large, pleomorphic nuclei with irregular membranes, chromatin clumps and prominent nucleoli...
May 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28537891/multiplex-pcr-approach-to-simultaneously-identify-several-mutations-in-fine-needle-cytology-thyroid-samples
#20
Emilia Vuttariello, Marco Borra, Elvira Mauriello, Celeste Calise, Barbara D'Andrea, Anna Capiluongo, Franco Fulciniti, Anna Cipolletta, Mario Monaco, Luciano Pezzullo, Gennaro Chiappetta
The most frequent initial manifestation of thyroid cancer is the appearance of a nodule. More than 20% of the general population has a palpable thyroid nodule and the percentage rises to 70% based on ultrasound identification. In 95% of cases the nodule is simply a hyperplastic or benign lesion. The most reliable diagnostic test for thyroid nodules is fine needle aspiration (FNA), but cytological discrimination between malignant and benign follicular neoplasms remains difficult. Cytological analysis is now, almost routinely, being combined with molecular genetics to enable the pathologist to make a more objective diagnosis...
May 7, 2017: Oncotarget
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