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https://www.readbyqxmd.com/read/28732311/solid-and-aqueous-magnetoliposomes-as-nanocarriers-for-a-new-potential-drug-active-against-breast-cancer
#1
Ana Rita O Rodrigues, Pedro M F Mendes, Pedro M L Silva, V A Machado, Bernardo G Almeida, J P Araújo, Maria-João R P Queiroz, Elisabete M S Castanheira, Paulo J G Coutinho
Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28732245/interleukin-4-receptor-targeted-delivery-of-bcl-xl-sirna-sensitizes-tumors-to-chemotherapy-and-inhibits-tumor-growth
#2
Padmanaban Guruprasath, Jihoon Kim, Gowri Rangaswamy Gunassekaran, Lianhua Chi, Soyoun Kim, Rang-Woon Park, Sang-Hyun Kim, Moon-Chang Baek, Sang Mun Bae, Sang-Yeob Kim, Dong-Kyu Kim, In-Kyu Park, Won-Jong Kim, Byungheon Lee
IL-4 receptor (IL-4R) is commonly up-regulated on tumor cells, and interactions between the receptor and Interleukin-4 (IL-4) can induce the expression of anti-apoptotic proteins, including Bcl-xL. This contributes to tumor cell survival and their resistance to chemotherapy. In this study, we exploited IL-4R-targeted delivery of Bcl-xL siRNA to IL-4R-expressing tumor cells in order to sensitize them to chemotherapy. To target IL-4R, an IL-4R-binding peptide, IL4RPep-1, was attached to branched polyethyleneimine-superparamagnetic iron oxide nanoparticles (BPEI-SPION)...
July 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28731079/a-polymeric-temozolomide-nanocomposite-against-orthotopic-glioblastoma-xenograft-tumor-specific-homing-directed-by-nestin
#3
Suma Prabhu, Jayant Sastri Goda, Srinivas Mutalik, Bhabani Shankar Mohanty, Pradip Chaudhari, Sharada Rai, Nayanabhirama Udupa, Bola Sadashiva Satish Rao
The development of effective therapeutic strategies for glioblastoma faces challenges such as modulating the blood brain barrier (BBB) for drug influx and selectively targeting tumor cells. Nanocarrier drug delivery strategies are functionalized to enhance vascular permeability. We engineered superparamagnetic iron oxide nanoparticle (SPION) based polymeric nanocomposites (84.37 ± 12.37 nm / 101.56 ± 7.42 nm) embedding temozolomide (TMZ) targeted against glioblastoma by tagging an antibody against nestin, a stem cell marker, and transferrin / polysorbate-80 to permeate the BBB...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28729284/visualising-inflammation-after-myocardial-infarction-with-the-use-of-iron-oxide-nanoparticles
#4
EDITORIAL
Ali Yilmaz
No abstract text is available yet for this article.
July 20, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28723064/doxorubicin-intracellular-remote-release-from-biocompatible-oegma-based-magnetic-nanogels-triggered-by-magnetic-hyperthermia
#5
Esther Cazares-Cortes, Ana Espinosa, Jean-Michel Guigner, Aude Michel, Nébéwia Griffete, Claire Wilhelm, Christine Menager
Hybrid nanogels, composed of thermoresponsive polymers and superparamagnetic nanoparticles (MNPs) are attractive nanocarriers for biomedical applications, being able - as polymer matrix - to uptake and release high quantities of chemotherapeutic agents and - as magnetic nanoparticles - to heat when exposed to an alternative magnetic field (AMF), better known as magnetic hyperthermia. Herein, biocompatible, pH-, magnetic- and thermo-responsive nanogels, based on oligo (ethylene glycol) methacrylate monomers (OEGMAs) and methacrylic acid co-monomer (MAA) were prepared by conventional precipitation radical co-polymerization in water, post-assembled by complexation with iron oxide magnetic nanoparticles (MNPs) of maghemite (-Fe2O3) and loaded with an anticancer drug (doxorubicin - DOX), for remotely controlled drug release by "hot-spot", as an athermal magnetic hyperthermia strategy against cancer...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722486/neurotoxic-effects-of-subchronic-intratracheal-mn-nanoparticle-exposure-alone-and-in-combination-with-other-welding-fume-metals-in-rats
#6
Zsuzsanna Máté, Edina Horváth, András Papp, Krisztina Kovács, Etelka Tombácz, Dániel Nesztor, Tamás Szabó, Andrea Szabó, Edit Paulik
Manganese (Mn) is a toxic heavy metal exposing workers in various occupational settings and causing, among others, nervous system damage. Metal fumes of welding, a typical source of Mn exposure, contain a complex mixture of metal oxides partly in nanoparticle form. As toxic effects of complex substances cannot be sufficiently understood by examining its components separately, general toxicity and functional neurotoxicity of a main pathogenic welding fume metal, Mn, was examined alone and combined with iron (Fe) and chromium (Cr), also frequently found in fumes...
July 19, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28719818/insights-into-the-unique-functionality-of-inorganic-micro-nanoparticles-for-versatile-ultrasound-theranostics
#7
REVIEW
Xiaoqin Qian, Xiaoxia Han, Yu Chen
The clinical ultrasound (US)-based theranostic biomedicine suffers from the critical issue that traditional microbubbles (MBs) have lots of drawbacks such as low stability, large particle size, difficult structural control, etc. The unique composition, structure and functionality of inorganic micro/nanoplatforms have shown their great prospect for solving these critical issues and drawbacks of traditional organic MBs. This review summarizes and discusses the state-of-art development on exploring inorganic micro/nanoparticles for versatile US-based biomedical applications, ranging from US imaging, photoacoustic imaging, sonodynamic therapy, high intensity-focused US ablation and US-triggered chemotherapy...
July 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28715773/developmental-toxicity-of-fe3o4-nanoparticles-on-cysts-and-three-larval-stages-of-artemia-salina
#8
Song Zhu, Ming-Yang Xue, Fei Luo, Wei-Chao Chen, Bin Zhu, Gao-Xue Wang
Using Artemia salina cysts (capsulated and decapsulated) and larvae (instar I, II and III) as experimental models, the potential effects of Fe3O4 nanoparticles (Fe3O4-NPs) on marine ecosystems were investigated. Hatchability, mortality and a number of ethological, morphological and biochemical parameters were selected as end-points to define the toxic responses. Data showed that the hatching rates of capsulated and decapsulated cysts were significantly decreased (p < 0.01) following exposure to 600 mg/L for 24 and 36 h...
July 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28710483/near-infrared-induced-phase-shifted-icg-fe3o4-loaded-plga-nanoparticles-for-photothermal-tumor-ablation
#9
Chengcheng Niu, Yan Xu, Senbo An, Ming Zhang, Yihe Hu, Long Wang, Qinghai Peng
Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe3O4), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe3O4/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709373/one-pot-synthesis-of-magnetic-iron-oxide-nanoparticle-multiwalled-carbon-nanotube-composites-for-enhanced-removal-of-cr-vi-from-aqueous-solution
#10
Wenhui Lu, Jinhua Li, Yanqing Sheng, Xinshen Zhang, Jinmao You, Lingxin Chen
Magnetic nanoparticle-multiwalled carbon nanotubes composites (MNP/MWCNTs) were prepared using 1,6-hexanediamine functionalized Fe3O4 nanoparticles (MNP) linked to carboxylic MWCNTs by facile one-pot solvothermal synthesis for highly efficient removal of Cr(VI) from aqueous solution. The easily obtained magnetic nanocomposites were systematically characterized, and several major factors affecting the adsorption-based removal were investigated, including solution pH, adsorbent dosage, temperature and contact time...
July 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28708983/preparation-of-nanoscale-iron-oxide-oxyhydroxides-and-zero-valent-particles-derived-from-blueberries-reactivity-characterization-and-removal-mechanism-of-arsenate
#11
Karen Manquián-Cerda, Edgardo Cruces, María Angélica Rubio, Camila Reyes, Nicolás Arancibia-Miranda
The application of iron nanoparticles (FeNPs) to the removal of various pollutants has received wide attention over the last few decades. A synthesis alternative to obtain these nanoparticles without using harmful chemical reagents, such as NaBH4, is the use of extracts from different natural sources that allow a lesser degree of agglomeration, in a process known as green synthesis. In this study, FeNPs were synthesized by 'green' (hereafter, BB-Fe NPs) and 'chemical' (hereafter, nZVI) methods. Extracts of leaves and blueberry shoots (Vaccinium corymbosum) were used as reducing agents for FeCl3·6H2O solution in the green synthesis method...
July 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28704722/arsanilic-acid-modified-superparamagnetic-iron-oxide-nanoparticles-for-purification-of-alkaline-phosphatase-from-hen-s-egg-yolk
#12
Hamed Farzi-Khajeh, Kazem D Safa, Siavoush Dastmalchi
Recent studies of magnetic carrier technology have focused on its applications in separation and purification technologies, due to easy separation of the target from the reaction medium by applying an external magnetic field. In the present study, Fe3O4 superparamagnetic nanoparticles were prepared to utilize a chemical co-precipitation method, then the surfaces of the nanoparticles were modified with arsanilic acid derivatives which were used as the specific nanocarriers for the affinity purification of alkaline phosphatase from the hen's egg yolk...
June 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28702640/a-simple-high-yield-synthesis-of-high-purity-h%C3%A3-gg-carbide-%C3%AF-fe5c2-nanoparticles-with-extraordinary-electrochemical-properties
#13
Ondřej Malina, Petr Jakubec, Josef Kašlík, Jiří Tuček, Radek Zbořil
Iron carbides are of eminent interest in both fundamental scientific research and in the industry owing to their properties such as excellent mechanical strength and chemical inertness. They have been found very effective in Fischer-Tropsch synthesis exploring heterogeneous catalysis for the production of chemicals such as liquid fuel and they have also been employed as successful promoters for the oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER). However, so far there have been only a few reports on the application of iron carbide nanoparticles in the field of electrochemical sensing...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28699008/fe3o4-nanoparticle-encapsulated-mesoporous-carbon-composite-an-efficient-heterogeneous-fenton-catalyst-for-phenol-degradation
#14
Angamuthu Mani, Thirumoorthy Kulandaivellu, Satishkumar Govindaswamy, Akhila Maheswari Mohan
Magnetite (Fe3O4) nanoparticle-encapsulated mesoporous carbon nanocomposite was fabricated from Fe-based metal-organic framework (MOF) (MIL-102) through carbonization. It was found that Fe-based MOF (MIL-102) is a potential precursor for the fabrication of hexagonal mesoporous carbon nanodisk functionalized with Fe3O4 nanoparticles. The obtained nanocomposite was characterized by XRD, FT-IR, N2 adsorption and desorption, FE-SEM and HRTEM techniques. As a Fenton-like solid catalyst for phenol degradation, Fe3O4 nanoparticle-encapsulated mesoporous carbon showed greater catalytic activity for the production of hydroxyl radical from the decomposition of H2O2 and it accomplished 100% phenol and 82% total organic carbon (TOC) conversion, within 120 min of reaction...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28695931/methods-of-protein-corona-isolation-for-magnetic-nanoparticles
#15
Debora Bonvin, Diego Chiappe, Marc Moniatte, Heinrich Hofmann, Marijana Mionić Ebersold
Nanoparticles (NPs) in contact with a biological environment get covered by proteins and some are loosely bound and some are tightly bound. The latter form a hard protein corona (HPC) which is known to determine their biological behavior. Therefore, in order to study the biological behaviour of NPs one needs to start from the HPC. However, established methods and standards of HPC isolation are still not known. This is especially a challenge in the case of magnetic NPs which form a major branch of nanomedicine...
July 11, 2017: Analyst
https://www.readbyqxmd.com/read/28693496/interaction-of-%C3%AE-fe2o3-nanoparticles-with-citrus-maxima-leaves-and-the-corresponding-physiological-effects-via-foliar-application
#16
Jing Hu, Huiyuan Guo, Junli Li, Yunqiang Wang, Lian Xiao, Baoshan Xing
BACKGROUND: Nutrient-containing nanomaterials have been developed as fertilizers to foster plant growth and agricultural yield through root applications. However, if applied through leaves, how these nanomaterials, e.g. γ-Fe2O3 nanoparticles (NPs), influence the plant growth and health are largely unknown. This study is aimed to assess the effects of foliar-applied γ-Fe2O3 NPs and their ionic counterparts on plant physiology of Citrus maxima and the associated mechanisms. RESULTS: No significant changes of chlorophyll content and root activity were observed upon the exposure of 20-100 mg/L γ-Fe2O3 NPs and Fe(3+)...
July 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28691796/oxidation-of-a-dimethoxyhydroquinone-by-ferrihydrite-and-goethite-nanoparticles-iron-reduction-versus-surface-catalysis
#17
Lelde Krumina, Gry Lyngsie, Anders Tunlid, Per Persson
Hydroquinones are important mediators of electron transfer reactions in soils with a capability to reduce Fe(III) minerals and molecular oxygen, and thereby generating Fenton chemistry reagents. This study focused on 2,6-dimethoxy hydroquinone (2,6-DMHQ), an analogue to a common fungal metabolite, and its reaction with ferrihydrite and goethite under variable pH and oxygen concentrations. Combined wet-chemical and spectroscopic analyses showed that both minerals effectively oxidized 2,6-DMHQ in the presence of oxygen...
July 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28689965/ph-and-nir-light-responsive-magnetic-iron-oxide-nanoparticles-for-mitochondria-mediated-apoptotic-cell-death-induced-by-chemo-photothermal-therapy
#18
Yunok Oh, Jae-Young Je, Madhappan Santha Moorthy, Hansoo Seo, Won Ho Cho
Recently, various therapeutic strategies in anticancer drug development are focused to reduce adverse side effects and to enhance the therapeutic efficacy. Mostly, the iron oxide (Fe3O4) nanoparticles have widely been utilized as an efficient drug delivery system towing to their unique properties such as excellent magnetic behavior, considerably low toxicity, easy surface modification and high drug-loading efficacy. In the present study, we synthesized a multifunctional, DMSA coated, water soluble Fe3O4 nanoparticles (Fe3O4@DMSA/DOX) for an effective pH and NIR-light triggered delivery of anticancer drug (DOX) in cancer therapy...
July 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28689117/development-of-non-pyrogenic-magnetosome-minerals-coated-with-poly-l-lysine-leading-to-full-disappearance-of-intracranial-u87-luc-glioblastoma-in-100-of-treated-mice-using-magnetic-hyperthermia
#19
Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, François Guyot, Imène Chebbi
Magnetic hyperthermia was reported to increase the survival of patients with recurrent glioblastoma by 7 months. This promising result may potentially be further improved by using iron oxide nanoparticles, called magnetosomes, which are synthesized by magnetotactic bacteria, extracted from these bacteria, purified to remove most endotoxins and organic material, and then coated with poly-l-lysine to yield a stable and non-pyrogenic nanoparticle suspension. Due to their ferrimagnetic behavior, high crystallinity and chain arrangement, these magnetosomes coated with poly-l-lysine (M-PLL) are characterized by a higher heating power than their chemically synthesized counterparts currently used in clinical trials...
June 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/28688987/tumor-targeting-by-lentiviral-vectors-combined-with-magnetic-nanoparticlesin-mice
#20
Ester Borroni, Marta Miola, Sara Ferraris, Giulia Ricci, Kristina ŽužekRožman, Nina Kostevšek, Angela Catizone, Lia Rimondini, Maria Prat, Enrica Verné, Antonia Follenzi
Nanomaterials conjugated or complexed with biological moieties such as antibodies, polymers or peptides appear to be suitable not only for drug delivery but also for specific cancer treatment. Here, biocompatible iron oxide magnetic nanoparticles (MNPs) with or without a silica shell coupled with lentiviral vectors (LVs) are proposed as a combined therapeutic approach to specifically target gene expression in a cancer mouse model. Initially, four different MNPs were synthesized and their physical properties were characterized to establish and discriminate their behaviors...
July 5, 2017: Acta Biomaterialia
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