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iron oxide nanoparticles

Titir Guha, K V G Ravikumar, Amitava Mukherjee, Anita Mukherjee, Rita Kundu
Engineered nanoparticles are utilized in agriculture for various purposes. They can be used as fertilizer, carrier for macro/micro nutrients or priming agents. Various nanoparticles are reported to have toxicity at very high doses, but at optimum concentration, they can be beneficial for plant growth and development. In the present study, low concentrations of nZVI nanoparticles were evaluated for their growth enhancement potential as seed priming agent in an aromatic rice cultivar, Oryza sativa cv. Gobindabhog...
April 12, 2018: Plant Physiology and Biochemistry: PPB
Rekha Bhar, Gurpreet Kaur, S K Mehta
For the first time, drying pattern of a sessile droplet of genomic DNA, in the presence of hematite nanoparticles was sighted by polarizing optical microscopy (POM) in this research article. POM results indicated that only at an appreciably high concentration of hematite nanoparticles dried pattern of deoxyribonucleic acid from calf thymus (CT-DNA) was altered. Iron hybridized cetylpyridinium chloride was utilized for the preparation of iron oxide nanoparticles through hydrothermal method. Fourier transforms infrared spectroscopy (FTIR) and powder x-ray diffraction (PXRD) studies confirmed the formation of highly crystalline hematite i...
April 20, 2018: Scientific Reports
Virginia S T Ciminelli, Daphne C Antônio, Claudia L Caldeira, Erico T F Freitas, Itamar Daniel Delbem, Marcus M Fernandes, Massimo Gasparon, Jack C Ng
A new analytical protocol was developed to provide quantitative, single-particle identification of arsenic in heterogeneous nanoscale mineral phases in soil samples, with a view to establishing its potential risk to human health. Microscopic techniques enabled quantitative, single-particle identification of As-bearing phases in twenty soil samples collected in a gold mining district with arsenic concentrations in range of 8 to 6354 mg kg-1 . Arsenic is primarily observed in association with iron (hydr) oxides in fine intergrowth with phyllosilicates...
March 29, 2018: Journal of Hazardous Materials
Mariana Neamtu, Claudia Nadejde, Vasile-Dan Hodoroaba, Rudolf J Schneider, Liliana Verestiuc, Ulrich Panne
Cost-effective water cleaning approaches using improved treatment technologies, for instance based on catalytic processes with high activity catalysts, are urgently needed. The aim of our study was to synthesize efficient Fenton-like photo-catalysts for rapid degradation of persistent organic micropollutants in aqueous medium. Iron-based nanomaterials were chemically synthesized through simple procedures by immobilization of either iron(II) oxalate (FeO) or iron(III) citrate (FeC) on magnetite (M) nanoparticles stabilized with polyethylene glycol (PEG)...
April 19, 2018: Scientific Reports
Lijiao Yang, Zhenyu Wang, Lengceng Ma, Ao Li, Jingyu Xin, Ruixue Wei, Hongyu Lin, Ruifang Wang, Zhong Chen, Jinhao Gao
The shape of magnetic nanoparticles is of great importance in determining their contrast abilities for magnetic resonance imaging. Various magnetic nanoparticles have been developed to achieve high T1 or T2 relaxivities, but the mechanism on how morphology influences the water proton relaxation process is still unrevealed. Herein we synthesize manganese-doped iron oxide (MnIO) nanoparticles of the same volume with six different shapes and reveal the relationship between morphologies and T1/T2 relaxation rates...
April 19, 2018: ACS Nano
Zhongyuan Guo, Nicole J Martucci, Yizhong Liu, Eusoo Yoo, Elad Tako, Gretchen J Mahler
The use of nanomaterials to enhance properties of food and improve delivery of orally administered drugs has become common, but the potential health effects of these ingested nanomaterials remain unknown. The goal of this study is to characterize the properties of silicon dioxide (SiO2 ) nanoparticles (NP) that are commonly used in food and food packaging, and to investigate the effects of physiologically realistic doses of SiO2 NP on gastrointestinal (GI) health and function. In this work, an in vitro model composed of Caco-2 and HT29-MTX co-cultures, which represent absorptive and goblet cells, was used...
April 18, 2018: Nanotoxicology
Weiqiong Ma, Qi Xie, Baolin Zhang, Huixian Chen, Jianyi Tang, Zhengxian Lei, Minyi Wu, Dingxuan Zhang, Jiani Hu
Magnetic resonance imaging (MRI) combined with contrast agents is believed to be useful for stem cell tracking in vivo, and the aim of this research was to investigate the biosafety and neural induction of SD rat-originated adipose derived stem cells (ADSCs) using cationic superparamagnetic iron oxide (SPIO) nanoparticle which was synthesized by the improved polyol method, in order to allow visualization using in vitro MRI. The scan protocols were performed with T2-mapping sequence; meanwhile, the ultrastructure of labeled cells was observed by transmission electron microscopy (TEM) while the iron content was measured by inductively coupled plasma-atomic emission spectrometry (ICP-AES)...
2018: Contrast Media & Molecular Imaging
Haidy Abbas, Hanan Refai, Nesrine El Sayed
The objective of the study was to target clonazepam (CZ) to the brain through the intranasal olfactory mucosa using nanolipid carriers loaded with superparamagnetic iron oxide nanoparticles (SPION) to allow nanocarrier guidance and retention with an external magnetic field. For improved delivery the nanolipid carriers were incorporated in a thermosensitive mucoadhesive in situ gel. Different nanolipid carriers including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were prepared and characterized with respect to particle size, zeta potential, entrapment efficiency and in vitro release...
April 14, 2018: Journal of Pharmaceutical Sciences
Wei Huang, Hongyu Sun, Huihui Shangguan, Xianyi Cao, Xinxin Xiao, Fei Shen, Kristian Mølhave, Lijie Ci, Pengchao Si, Jingdong Zhang
Three-dimensional (3D) carbon-wrapped iron sulfide interlocked graphene (Fe7S8@C-G) composites for high-performance sodium-ion storage are designed and produced through electrostatic interactions and subsequent sulfurization. The iron-based metal-organic frameworks (MOFs, MIL-88-Fe) interact with graphene oxide sheets to form 3D networks, and carbon-wrapped iron sulfide (Fe7S8@C) nanoparticles with high individual-particle conductivity are prepared following a sulfurization process, surrounded by interlocked graphene sheets to enhance the interparticle conductivity...
April 17, 2018: Nanoscale
Amit P Khandhar, Gregory J Wilson, Michael G Kaul, Johannes Salamon, Caroline Jung, Kannan M Krishnan
Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles provide a safer alternative to gadolinium-based contrast agents (GBCAs) in T1-weighted MR imaging. MRI contrast behavior of USPIOs depends on their magnetic properties, which in turn depend on their physicochemical composition. Identifying and tailoring USPIO structural characteristics that influence proton relaxation in MRI is crucial to developing effective gadolinium-free T1 contrast agents. Here we present a systematic empirical evaluation of the relationship between USPIO size and MRI relaxivity (r1 and r2 values)...
April 17, 2018: Journal of Biomedical Materials Research. Part A
Halla Laufey Hauksdóttir, Thomas J Webster
Iron oxide nanoparticles (IONP) are already well-established in the medical field due to their ability to improve contrast in magnetic resonance imaging (MRI) and for their external magnetic control in the body. Moreover, selenium has been shown to kill numerous cancer cells at lower concentrations that IONP (e.g., 1 μg/ml). Selenium is a trace mineral of growing interest in cancer treatment since it is an essential nutrient in the human body and can interfere with thiolcontaining proteins necessary for cancer cells to function...
March 1, 2018: Journal of Biomedical Nanotechnology
Stefan Herz, Patrick Vogel, Philipp Dietrich, Thomas Kampf, Martin A Rückert, Ralph Kickuth, Volker C Behr, Thorsten A Bley
PURPOSE: To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model. MATERIALS AND METHODS: Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l)...
April 16, 2018: Cardiovascular and Interventional Radiology
Loren Ochoa, Nubia Zuverza-Mena, Illya A Medina-Velo, Juan Pedro Flores-Margez, José R Peralta-Videa, Jorge L Gardea-Torresdey
The interaction of CuO nanoparticles (nCuO), a potential nanopesticide, with the growth hormone indole-3-acetic acid (IAA) is not well understood. This study aimed to evaluate the nutritional components in seeds of green pea (Pisum sativum) cultivated in soil amended with nCuO at 50 or 100mgkg-1 , with/without IAA at 10 or 100μM. Similar treatments including bulk CuO (bCuO) and CuCl2 were set as controls. Bulk CuO at 50mgkg-1 reduced seed yield (52%), compared with control. Bulk CuO at 50mgkg-1 and nCuO at 100mgkg-1 , plus IAA at 100μM, increased iron in seeds (41 and 42%, respectively), while nCuO at 50mgkg-1 , plus IAA at 100μM reduced boron (80%, respect to control and 63%, respect to IAA at 100μM)...
April 12, 2018: Science of the Total Environment
Lukas Zeininger, Lisa M S Stiegler, Luis Portilla, Marcus Halik, Andreas Hirsch
We describe a universal wet-chemical shell-by-shell coating procedure resulting in colloidal titanium dioxide (TiO2 ) and iron oxide (Fe3 O4 ) nanoparticles with dynamically and reversibly tunable surface energies. A strong covalent surface functionalization is accomplished by using long-chained alkyl-, triethylenglycol-, and perfluoroalkylphosphonic acids, yielding highly stabilized core-shell nanoparticles with hydrophobic, hydrophilic, or superhydrophobic/fluorophilic surface characteristics. This covalent functionalization sequence is extended towards a second noncovalent attachment of tailor-made nonionic amphiphilic molecules to the pristine coated core-shell nanoparticles via solvophobic (i...
April 2018: ChemistryOpen
Andra Mihaela Predescu, Ecaterina Matei, Andrei Constantin Berbecaru, Cristian Pantilimon, Claudia Drăgan, Ruxandra Vidu, Cristian Predescu, Victor Kuncser
Synthesis and characterization of iron oxide nanoparticles coated with a large molar weight dextran for environmental applications are reported. The first experiments involved the synthesis of iron oxide nanoparticles which were coated with dextran at different concentrations. The synthesis was performed by a co-precipitation technique, while the coating of iron oxide nanoparticles was carried out in solution. The obtained nanoparticles were characterized by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction spectrometry, Fourier transform infrared spectroscopy and superconducting quantum interference device magnetometry...
March 2018: Royal Society Open Science
Ana Isabel Bocanegra Gondan, Ane Ruiz-de-Angulo, Aintzane Zabaleta, Nina Gómez Blanco, Beatriz Macarena Cobaleda-Siles, María Jesús García-Granda, Daniel Padro, Jordi Llop, Blanca Arnaiz, María Gato, David Escors, Juan C Mareque-Rivas
Encouraging results are emerging from systems that exploit Toll like receptor (TLR) signaling, nanotechnology, checkpoint inhibition and molecular imaging for cancer immunotherapy. A major remaining challenge is developing effective, durable and tumour-specific immune responses without systemic toxicity. Here, we report a simple and versatile system based on synergistic activation of immune responses and direct cancer cell killing by combined TLR ligation using polyIC as TLR3 and imiquimod (R837) as TLR7 agonist, in combination with the model antigen ovalbumin (OVA) and phospholipid micelles loaded with zinc-doped iron oxide magnetic nanoparticles (MNPs)...
April 3, 2018: Biomaterials
Gauri M Nabar, Jessica O Winter, Barbara E Wyslouzil
The interfacial instability method has emerged as a viable approach for encapsulating high concentrations of nanoparticles (NPs) within morphologically diverse micelles. In this method, transient interfacial instabilities at the surface of an emulsion droplet guide self-assembly of block co-polymers and NP encapsulants. Although used by many groups, there are no systematic investigations exploring the relationship between NP properties and micelle morphology. Here, the effect of quantum dot (QD) and superparamagnetic iron oxide NP (SPION) concentration on the shape, size, and surface deformation of initially spherical poly(styrene-b-ethylene oxide) (PS-b-PEO) micelles was examined...
April 13, 2018: Soft Matter
Hailin Tang, Yuan Guo, Li Peng, Hui Fang, Zhigang Wang, Yuanyi Zheng, Haitao Ran, Yu Chen
As one of the most representative non-invasive therapeutic modalities, high-intensity focused ultrasound (HIFU) has shown the great promise for cancer therapy, but its low therapeutic efficacy and biosafety significantly hinder the further extensive clinical translation and application. In this work, we report on the construction of a multifunctional theranostic nanoplatform to synergistically enhance the HIFU-therapeutic efficacy based on nanomedicine. A targeted and temperature-responsive theranostic nanoplatform (PFH/DOX@PLGA/Fe3O4-FA) has been designed and fabricated for efficient ultrasound/magnetic resonance dual-modality imaging-guided HIFU/chemo synergistic therapy...
April 13, 2018: ACS Applied Materials & Interfaces
Run Lin, Jing Huang, Liya Wang, Yuancheng Li, Malgorzata Lipowska, Hui Wu, Jianyong Yang, Hui Mao
Vascular endothelial growth factor (VEGF) plays a pivotal role in the cascade of development and progression of cancers. Targeting this cancer hallmark is a logical strategy for imaging based cancer detection and monitoring the anti-angiogenesis treatment. Using Bevacizumab (Avastin®), which is a recombinant humanized monoclonal antibody directly against VEGF and an angiogenesis inhibitor, as a targeting ligand, a multimodal VEGF targeted molecular imaging probe was developed by conjugating near infrared dye (NIR830) labeled bevacizumab to magnetic iron oxide nanoparticles (IONP) for optical and magnetic resonance (MR) imaging of cancers over-expressing VEGF...
April 13, 2018: Biomaterials Science
Jaydev R Upponi, Kaushal Jerajani, Dattatri K Nagesha, Praveen Kulkarni, Srinivas Sridhar, Craig Ferris, Vladimir P Torchilin
Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro...
March 31, 2018: Biomaterials
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