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https://www.readbyqxmd.com/read/28529585/efficacy-of-recombinant-human-adenovirus-p53-combined-with-chemotherapy-for-locally-advanced-cervical-cancer-a-clinical-trial
#1
Jie Xiao, Jian Zhou, Min Fu, Li Liang, Qiaoling Deng, Xiaoyun Liu, Fumin Liu
The aim of this study was to evaluate the efficacy and safety of recombinant human adenovirus-p53 (rhAd-p53) combined with neoadjuvant chemotherapy in treatment of locally advanced cervical cancer (LACC). A total of 40 patients with LACC (stage IB2 to IIIA) were randomized into 2 groups (n=20 each): PVB group (cisplatin + vincristine + bleomycin, intravenously) and combined group (rhAd-p53 gene therapy + neoadjuvant chemotherapy). Both groups underwent a course of chemotherapy; the only exception was the injection of the rhAd-p53 solution 1×10(12) VP intratumorally at an interval of three days thrice in the combined group thereafter...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28525509/analgesic-choice-in-management-of-rib-fractures-paravertebral-block-or-epidural-analgesia
#2
Mahdi Malekpour, Ammar Hashmi, James Dove, Denise Torres, Jeffrey Wild
BACKGROUND: Rib fractures are commonly encountered in the setting of trauma. The aim of this study was to assess the association between the clinical outcome of rib fracture and epidural analgesia (EA) versus paravertebral block (PVB) using the National Trauma Data Bank (NTDB). METHODS: Using the 2011 and 2012 versions of the NTDB, we retrieved completed records for all patients above 18 years of age who were admitted with rib fractures. Primary outcome was in-hospital mortality...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28499915/early-life-stress-and-later-peer-distress-on-depressive-behavior-in-adolescent-female-rats-effects-of-a-novel-intervention-on-gaba-and-d2-receptors
#3
Jodi L Lukkes, Shirisha Meda, Britta S Thompson, Nadja Freund, Susan L Andersen
Early life adversity (ELA) increases the risk of depression during adolescence that may result from a decline in parvalbumin (PVB) secondary to increased neuroinflammation. In this study, we investigated depressive-like behavior following exposure to two different types of stressors that are relevant for their developmental period: 1) chronic ELA (maternal separation; MS) and 2) an acute emotional stressor during adolescence (witnessing their peers receive multiple shocks; WIT), and their interaction. We also determined whether reducing inflammation by cyclooxygenase-2 (COX-2) inhibition would prevent the onset of depressive-like behavior...
May 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28455286/ultrasound-biomicroscopy-validation-of-a-murine-model-of-cardiac-hypertrophic-preconditioning-comparison-with-a-hemodynamic-assessment
#4
Jiayuan Huang, Jian Wu, Shijun Wang, Jieyun You, Yong Ye, Zhiwen Ding, Fenghua Yang, Xingxu Wang, Junjie Guo, Leilei Ma, Jie Yuan, Yunli Shen, Xiangdong Yang, Aijun Sun, Hong Jiang, Liping Bu, Peter H Backx, Junbo Ge, Yunzeng Zou
In mice, myocardial hypertrophic preconditioning (HP), which is produced by the removal of short-term transverse aortic constriction (TAC), was recently reported to render the heart resistant to hypertrophic responses induced by subsequent re-constriction (Re-TAC). However, there is no efficient non-invasive method for ensuring that the repeated aortic manipulations were successfully performed. We previously demonstrated that ultrasound biomicroscopy (UBM) is a non-invasive and effective approach for predicting TAC success...
April 28, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28335980/paper-polymer-composite-devices-with-minimal-fluorescence-background
#5
Chang-Ming Wang, Chong-You Chen, Wei-Ssu Liao
Polymer film incorporated paper-based devices show advantages in simplicity and rugged backing. However, their applications are restricted by the high fluorescence background interference of conventional laminating pouches. Herein, we report a straightforward approach for minimal fluorescence background device fabrication, in which filter paper was shaped and laminated in between two biaxially oriented polypropylene (OPP) and polyvinyl butyral (PVB) composite films. This composite film provides mechanical strength for enhanced device durability, protection from environmental contamination, and prevents reagent degradation...
April 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28217050/acoustic-puncture-assist-device%C3%A2-versus-conventional-loss-of-resistance-technique-for-thoracic-paravertebral-space-identification-clinical-and-ultrasound-evaluation
#6
Monaz Abdulrahman Ali, Ashraf Abualhasan Abdellatif
BACKGROUND: Acoustic puncture assist device (APAD™) is a pressure measurement combined with a related acoustic signal that has been successfully used to facilitate epidural punctures. The principal of loss of resistance (LOR) is similar when performing paravertebral block (PVB). We investigated the usefulness of APAD™ by comparing it with the conventional LOR techniques for identifying paravertebral space (PVS). SUBJECTS AND METHODS: A total of 100 women who were scheduled for elective breast surgery under general anesthesia with PVB were randomized into two equal groups...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28208979/evaluation-of-the-efficacy-of-bupivacaine-0-5-alone-or-with-clonidine-1%C3%AE-g-kg-versus-control-in-a-single-level-paravertebral-blockin-patients-undergoing-pcnl-procedure
#7
Trupti S Kamble, Charulata Mahesh Deshpande
INTRODUCTION: Percutaneous Nephrolithotomy (PCNL) is a widely used procedure to remove complex upper tract renal calculi by means of a nephroscope. Although less invasive, PCNL is associated with significant pain owing to soft tissue injury. Most of these patients have mild to moderately compromised renal function. An anaesthesia plan that reduces intraoperative requirement of anaesthetics, analgesics, muscle relaxants and postoperative requirement of systemic analgesics is essential...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28122571/continuous-paravertebral-block-using-a-thoracoscopic-catheter-insertion-technique-for-postoperative-pain-after-thoracotomy-a-retrospective-case-control-study
#8
Yoshikane Yamauchi, Mitsuhiro Isaka, Kamon Ando, Keita Mori, Hideaki Kojima, Tomohiro Maniwa, Shoji Takahashi, Eiji Ando, Yasuhisa Ohde
BACKGROUND: Thoracic epidural analgesia (EDA) is the gold standard for pain control after thoracotomy. However, because of its severe side effects, it is contraindicated in patients taking anticoagulant or antiplatelet drugs. In addition, some patients' anatomy can make epidural catheter insertion challenging. We therefore investigated the safety and efficacy of paravertebral block (PVB) using a thoracoscopic insertion technique, which avoids damage to the parietal pleura, for postoperative pain after thoracotomy...
January 25, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28116506/a-randomized-controlled-trial-comparing-paravertebral-block-via-the-surgical-field-with-thoracic-epidural-block-using-ropivacaine-for-post-thoracotomy-pain-relief
#9
Takahiro Tamura, Shoichi Mori, Atsushi Mori, Masahiko Ando, Shuichi Yokota, Yasuyuki Shibata, Kimitoshi Nishiwaki
PURPOSE: We conducted a comparative study to evaluate analgesic efficacy between paravertebral block via the surgical field (PVB-sf), in which the catheter was inserted into the ventral side of the sympathetic trunk in the paravertebral space by a thoracic surgeon under thoracoscopic visualization, and epidural block (Epi) using ropivacaine for post-thoracotomy pain relief. METHODS: Lung cancer patients scheduled for lobectomy via thoracotomy were randomly allocated to receive either PVB-sf or Epi (n = 36 per group)...
January 23, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28100519/paravertebral-block-in-paediatric-abdominal-surgery-a-systematic-review-and-meta-analysis-of-randomized-trials
#10
E A Page, K L Taylor
The increased popularity of paravertebral block (PVB) can be attributed to its relative safety and comparable efficacy when compared with epidural analgesia. It has thus been recommended for open cholecystectomy and other less painful surgeries such as inguinal herniorraphy and appendectomy. We performed a systematic review of PVB in paediatric abdominal conditions to assess its clinical efficacy and side effects compared with other analgesic therapies.A search of Medline, Embase, and Web of Science and hand-searching references from inception date to May 2016 was done...
February 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28055111/there-and-back-again-loss-and-reacquisition-of-two-cys-photocycles-in-cyanobacteriochromes
#11
Nathan C Rockwell, Shelley S Martin, J Clark Lagarias
Cyanobacteriochromes (CBCRs) are cyanobacterial photoreceptors distantly related to phytochromes. Both families use linear tetrapyrrole (bilin) chromophores that are covalently attached to a conserved Cys residue. CBCRs are more spectrally diverse than phytochromes, with known examples detecting light from the near ultraviolet to the edge of the infrared (370-750 nm). Detection of ultraviolet to blue light by CBCRs is mediated by a second Cys residue, which forms a covalent linkage to the bilin C10 atom. Second linkage formation is best understood in a subfamily possessing a conserved Asp-Xaa-Cys-Phe (DXCF) motif...
January 5, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28000203/comparison-of-continuous-epidural-block-and-continuous-paravertebral-block-in-postoperative-analgaesia-after-video-assisted-thoracoscopic-surgery-lobectomy-a-randomised-non-inferiority-trial
#12
RANDOMIZED CONTROLLED TRIAL
Sylweriusz Kosiński, Edward Fryźlewicz, Michał Wiłkojć, Adam Ćmiel, Marcin Zieliński
BACKGROUND: Video-assisted (VATS) lung lobectomy can be associated with stronger postoperative pain than is commonly believed. It is generally accepted to introduce multimodal analgaesic strategies based on regional blockade, opioids and non-steroidal anti-inflammatory drugs. However, there is still no consensus regarding the optimal regional technique. The aim of this study was to compare the analgaesic efficacy of continuous thoracic epidural block (TEA) and percutaneous continuous paravertebral block (PVB) in patients undergoing video-assisted lung lobectomy...
2016: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/27936555/low-temperature-all-solution-processed-transparent-silver-nanowire-polymer-azo-nanoparticles-composite-electrodes-for-efficient-ito-free-polymer-solar-cells
#13
Xiaoqin Zhang, Jiang Wu, Jiantai Wang, Qingqing Yang, Baohua Zhang, Zhiyuan Xie
We present a kind of all-solution-processed transparent conductive film comprising of silver nanowire (AgNW), polyvinyl butyral (PVB), and Al-doped ZnO nanoparticles (AZO NPs) composite (APA) by layer-by-layer blade-coating on glass substrate at low temperature. This kind of transparent APA film exhibits high transmittance at a wide range of 400-700 nm. The sheet resistance of the APA film can be as low as 21 Ω sq(-1) with transmittance over 94% at 550 nm. The introduction of PVB significantly improves the APA composite adhesion to glass substrate...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27921281/colorful-hydrophobic-poly-vinyl-butyral-cationic-dye-fibrous-membranes-via-a-colored-solution-electrospinning-process
#14
Xu Yan, Ming-Hao You, Tao Lou, Miao Yu, Jun-Cheng Zhang, Mao-Gang Gong, Fu-Yan Lv, Yuan-Yuan Huang, Yun-Ze Long
Colorful nanofibrous membranes have attracted much attention for their visual varieties and various functionalities. In this article, a colored solution electrospinning process was used to fabricate colorful hydrophobic poly(vinyl butyral) (PVB)/cationic dye nanofibrous membranes (NFMs) successfully. The color and morphology of these as-spun nanofibrous membranes have been analyzed by colorimetry, spectroscopy, and scanning electron microscopy (SEM). It is shown that the as-spun colorful PVB-based membranes exhibit excellent level-dyeing property and color stability...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27909035/randomised-controlled-pilot-study-to-investigate-the-effectiveness-of-thoracic-epidural-and-paravertebral-blockade-in-reducing-chronic-post-thoracotomy-pain-topic-feasibility-study-protocol
#15
Joyce Yeung, Teresa Melody, Amy Kerr, Babu Naidu, Lee Middleton, Kostas Tryposkiadis, Jane Daniels, Fang Gao
INTRODUCTION: Open chest surgery (thoracotomy) is considered the most painful of surgical procedures. Forceful wound retraction, costochondral dislocation, posterior costovertebral ligament disruption, intercostal nerve trauma and wound movement during respiration combine to produce an acute, severe postoperative pain insult and persistent chronic pain many months after surgery is common. Three recent systematic reviews conclude that unilateral continuous paravertebral blockade (PVB) provides analgesia at least equivalent to thoracic epidural blockade (TEB) in the postoperative period, has a lower failure rate, and symptom relief that lasted months...
December 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/27908143/efficient-molecular-quantum-dynamics-in-coordinate-and-phase-space-using-pruned-bases
#16
H R Larsson, B Hartke, D J Tannor
We present an efficient implementation of dynamically pruned quantum dynamics, both in coordinate space and in phase space. We combine the ideas behind the biorthogonal von Neumann basis (PvB) with the orthogonalized momentum-symmetrized Gaussians (Weylets) to create a new basis, projected Weylets, that takes the best from both methods. We benchmark pruned time-dependent dynamics using phase-space-localized PvB, projected Weylets, and coordinate-space-localized DVR bases, with real-world examples in up to six dimensions...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27858290/complete-sequence-and-variability-of-a-new-subgroup-b-nepovirus-infecting-potato-in-central-peru
#17
Joao De Souza, Giovanna Müller, Wilmer Perez, Wilmer Cuellar, Jan Kreuze
The complete bipartite genome (RNA1 and RNA2) of a new nepovirus infecting potato was obtained using small RNA sequencing and assembly complemented by Sanger sequencing. Each RNA encodes a single polyprotein, flanked by 5' and 3' untranslate regions (UTR) and followed by a poly (A) tail. The putative polyproteins encoded by RNA1 and RNA2 had sets of motifs which are characteristic of viruses in the genus Nepovirus. Sequence comparisons using the Pro-Pol region and the coat protein, including phylogenetic analysis of these regions, showed closest relationships with nepoviruses...
March 2017: Archives of Virology
https://www.readbyqxmd.com/read/27742320/organ-donation-and-transplantation-from-donors-with-systemic-infection-a-single-center-experience
#18
X Yuan, C Chen, J Zhou, M Han, X Wang, C Wang, X He
OBJECTIVES: Donors with bacteremia and sepsis are often considered to be controversial for organ retrieval due to potential transmission of an infectious agent to the recipient. Herein we report our initial experience of organ donation and transplantation results from donors with systemic infection. MATERIALS AND METHODS: From January 2013 to December 2014, 125 cases of donation were completed in our organ procurement organization including 90 cases of donation after brain death (DBD) and 35 cases of donation after circulatory death (DCD)...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27685344/the-impact-of-paravertebral-block-analgesia-on-breast-cancer-survival-after-surgery
#19
Juan P Cata, Mariana Chavez-MacGregor, Vicente Valero, Walter Black, Daliah M Black, Farzin Goravanchi, Ifey C Ifeanyi, Mike Hernandez, Andrea Rodriguez-Restrepo, Vijaya Gottumukkala
BACKGROUND AND OBJECTIVES: The impact of regional anesthesia on breast cancer recurrence is controversial. We tested the hypothesis that the use of paravertebral block (PVB) analgesia during breast cancer surgery prolongs the recurrence-free survival (RFS) and overall survival (OS) of women with breast cancer. METHODS: Seven hundred ninety-two women with nonmetastatic breast cancer were included in this retrospective study. Patients were divided based on the administration of PVB analgesia for mastectomy surgeries...
November 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27586312/-thoracic-paravertebral-block-in-patients-ineligible-for-epidural-block
#20
Hideaki Kojima, Mitsuhiro Isaka, Yoshiyuki Yasuura, Reiko Shimizu, Hiroyuki Kayata, Shoji Takahashi, Eiji Ando, Yasuhisa Ohde
We retrospectively assessed the effectiveness and the safety of thoracic paravertebral block(PVB) in patients ineligible for epidural block (EP). Eleven PVB patients and 33 EP patients were enrolled. Postoperative pain was evaluated using a numerical rating scale (NRS). The mean NRS ± standard deviation at rest 24 and 48 hours after surgery were 1.36 ± 1.63 and 0.55 ± 1.03 in the PVB group and 1.07 ± 1.47 and 1.38 ± 1.31 in the EP group, respectively. There were no statistically significant differences in the NRS scores...
September 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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