keyword
MENU ▼
Read by QxMD icon Read
search

regenerate biology

keyword
https://www.readbyqxmd.com/read/28821138/biocompatible-chitin-carbon-nanotubes-composite-hydrogels-as-neuronal-growth-substrates
#1
Shuangquan Wu, Bo Duan, Ang Lu, Yanfeng Wang, Qifa Ye, Lina Zhang
In the past decades, extensive studies have demonstrated that carbon nanotubes (CNTs) could promote cell adhesion, proliferation and differentiation of neuronal cells. However, the potential cytotoxicity in biological systems severely restricted the utilization of CNTs as substrates for neural growth. In this study, biocompatible chitin/carbon nanotubes (Ch/CNT) composite hydrogels were developed via blending modified CNTs with chitin solution in 11wt% NaOH/4wt% urea aqueous system, and subsequently regenerating in ethanol...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820983/a-sensitive-method-for-the-separation-and-quantification-of-low-level-adenine-nucleotides-using-porous-graphitic-carbon-based-liquid-chromatography-and-tandem-mass-spectrometry
#2
Sonia Bustamante, Robert B Gilchrist, Dulama Richani
A liquid chromatography coupled to heated electrospray ionization/tandem mass spectrometry (LC-HESI-MS/MS) method was developed for the simultaneous quantitative analysis of low nanomolar level adenine nucleotides AMP, ADP, ATP, cyclic AMP (cAMP), and the nucleoside adenosine. For analyte retention and separation, reverse phase chromatography using porous graphitic carbon (PGC) was employed as it provided full resolution. The erratic chromatographic behaviour characteristic of PGC, including deterioration of analyte resolution and increased peak tailing (leading to decreased sensitivity), was mitigated by incorporating acidic equilibration within runs using a quaternary gradient...
July 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28820316/cell-cycle-related-metabolism-and-mitochondrial-dynamics-in-a-replication-competent-pancreatic-beta-cell-line
#3
Chiara Montemurro, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E Butler, Kenny E Vongbunyong, Anton Petcherski, Orian S Shirihai, Leslie S Satin, Daniel Braas, Peter C Butler, Slavica Tudzarova
Cell replication is a fundamental attribute of growth and repair in multicellular organisms. Pancreatic beta-cells in adults rarely enter cell cycle, hindering the capacity for regeneration in diabetes. Efforts to drive beta-cells into cell cycle have so far largely focused on regulatory molecules such as cyclins and cyclin-dependent kinases (CDKs). Investigations in cancer biology have uncovered that adaptive changes in metabolism, the mitochondrial network, and cellular Ca(2+) are critical for permitting cells to progress through the cell cycle...
August 18, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28819314/a-symbiotic-like-biologically-driven-regenerating-fabric
#4
Neta Raab, Joe Davis, Rachel Spokoini-Stern, Moran Kopel, Ehud Banin, Ido Bachelet
Living organisms constantly maintain their structural and biochemical integrity by the critical means of response, healing, and regeneration. Inanimate objects, on the other hand, are axiomatically considered incapable of responding to damage and healing it, leading to the profound negative environmental impact of their continuous manufacturing and trashing. Objects with such biological properties would be a significant step towards sustainable technology. In this work we present a feasible strategy for driving regeneration in fabric by means of integration with a bacterial biofilm to obtain a symbiotic-like hybrid - the fabric provides structural framework to the biofilm and supports its growth, whereas the biofilm responds to mechanical tear by synthesizing a silk protein engineered to self-assemble upon secretion from the cells...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818620/secrets-from-immortal-worms-what-can-we-learn-about-biological-ageing-from-the-planarian-model-system
#5
REVIEW
Sounak Sahu, Anish Dattani, A Aziz Aboobaker
Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. While research in genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these studies have been performed in established model organisms, amenable to both classical and molecular genetic approaches, with relatively short lifespans. Here we consider the use of planarians, with an immortal life-history that is able to entirely avoid the ageing process...
August 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28817983/the-use-of-soft-robotics-in-cardiovascular-therapy
#6
Isaac Wamala, Ellen T Roche, Frank A Pigula
Robots have been employed in cardiovascular therapy as surgical tools and for automation of hospital systems. Soft robots are a new kind of robot made of soft deformable materials. They are uniquely suited for biomedical applications because they are inherently less likely to injure body tissues and more likely to adapt to biological environments. Awareness of the soft robotic systems under development will help promote clinician involvement in their successful translation for therapeutic use. Areas Covered: The soft robotic systems, across the size scale from nano to macro, that have shown the most promise for clinical application in cardiovascular therapy because they represent the most mature technology and also they offer solutions where a clear therapeutic need still exists...
August 18, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28817534/radius-regeneration-after-open-fracture-and-extrusion-a-case-report
#7
Kristopher B McCall, David Y Chong
A pediatric patient presenting with an open forearm fracture with segmental defect is rare, and the pediatric orthopedic literature to guide treatment is sparse. There are several described methods to treat the defect, including bone grafting and bone transport techniques. In addition, there are reports of fibular regeneration after resection if the periosteum is left intact. We present a case report of complete regeneration of over half of a pediatric radial shaft with an intact periosteum, after traumatic extrusion from an open fracture...
August 16, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28815441/pluripotent-stem-cells-in-adult-tissues-struggling-to-be-acknowledged-over-two-decades
#8
REVIEW
Deepa Bhartiya
Stem cells have fascinated scientists for a long time and huge research efforts have been put into them as they have the potential to regenerate diseased organs. Besides embryonic stem cells (ES) and induced pluripotent stem cells (iPS), it has been postulated that pluripotent stem cells (PSCs) may also exist in various adult tissues. They are thought to be more primitive than the adult stem cells (ASCs), serve as a backup pool to give rise to ASCs and thus play a crucial role in maintaining life-long homeostasis...
August 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28814609/tail-regeneration-and-other-phenomena-of-wound-healing-and-tissue-restoration-in-lizards
#9
REVIEW
Kathy Jacyniak, Rebecca P McDonald, Matthew K Vickaryous
Wound healing is a fundamental evolutionary adaptation with two possible outcomes: scar formation or reparative regeneration. Scars participate in re-forming the barrier with the external environment and restoring homeostasis to injured tissues, but are well understood to represent dysfunctional replacements. In contrast, reparative regeneration is a tissue-specific program that near-perfectly replicates that which was lost or damaged. Although regeneration is best known from salamanders (including newts and axolotls) and zebrafish, it is unexpectedly widespread among vertebrates...
August 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28811579/cxcl12-enhances-angiogenesis-through-cxcr7-activation-in-human-umbilical-vein-endothelial-cells
#10
Min Zhang, Lisha Qiu, Yanyan Zhang, Dongsheng Xu, Jialin C Zheng, Li Jiang
Angiogenesis is the process by which new vessels form from existing vascular networks. Human umbilical vein endothelial cells (HUVECs) may contribute to the study of vascular repair and angiogenesis. The chemokine CXCL12 regulates multiple cell functions, including angiogenesis, mainly through its receptor CXCR4. In contrast to CXCL12/CXCR4, few studies have described roles for CXCR7 in vascular biology, and the downstream mechanism of CXCR7 in angiogenesis remains unclear. The results of the present study showed that CXCL12 dose-dependently enhanced angiogenesis in chorioallantoic membranes (CAMs) and HUVECs...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811217/regulation-and-phylogeny-of-skeletal-muscle-regeneration
#11
REVIEW
Meryem B Baghdadi, Shahragim Tajbakhsh
One of the most fascinating questions in regenerative biology is why some animals can regenerate injured structures while others cannot. Skeletal muscle has a remarkable capacity to regenerate even after repeated traumas, yet limited information is available on muscle repair mechanisms and how they have evolved. For decades, the main focus in the study of muscle regeneration was on muscle stem cells, however, their interaction with their progeny and stromal cells is only starting to emerge, and this is crucial for successful repair and re-establishment of homeostasis after injury...
August 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28810121/comparative-proteomic-and-transcriptomic-analysis-of-follistatin-induced-skeletal-muscle-hypertrophy
#12
Caroline Barbé, Fabrice Bray, Marine Gueugneau, Stéphanie Devassine, Pascale Lause, Caroline Tokarski, Christian Rolando, Jean-Paul Thissen
Skeletal muscle, the most abundant body's tissue, plays vital roles in locomotion and metabolism. Myostatin is a negative regulator of skeletal muscle mass. In addition to increase muscle mass, Myostatin inhibition impacts on muscle contractility and energy metabolism. To decipher the mechanisms of action of the Myostatin inhibitors, we used proteomic and transcriptomic approaches to investigate the changes induced in skeletal muscles of transgenic mice overexpressing Follistatin, a physiological Myostatin inhibitor...
August 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28806146/three-dimensional-bioprinting-of-polycaprolactone-reinforced-gene-activated-bioinks-for-bone-tissue-engineering
#13
Gráinne M Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly
Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool biofabrication has permitted the combination of various biomaterials to create multifaceted composites with tailorable mechanical properties and spatially controlled biological function. In this study we sought to use bioprinting to engineer nonviral gene activated constructs reinforced by polymeric micro-filaments. A gene activated bioink was developed using RGD-γ-irradiated alginate and nano-hydroxyapatite (nHA) complexed to plasmid DNA (pDNA)...
August 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28804984/3d-bioprinting-for-cartilage-and-osteochondral-tissue-engineering
#14
REVIEW
Andrew C Daly, Fiona E Freeman, Tomas Gonzalez-Fernandez, Susan E Critchley, Jessica Nulty, Daniel J Kelly
Significant progress has been made in the field of cartilage and bone tissue engineering over the last two decades. As a result, there is real promise that strategies to regenerate rather than replace damaged or diseased bones and joints will one day reach the clinic however, a number of major challenges must still be addressed before this becomes a reality. These include vascularization in the context of large bone defect repair, engineering complex gradients for bone-soft tissue interface regeneration and recapitulating the stratified zonal architecture present in many adult tissues such as articular cartilage...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28804684/bioresorbable-scaffold-as-a-dermal-substitute
#15
Lenon Cardoso, Marília Colturato Cleto, Maria Lourdes Peris Barbo, Andréa Rodrigues Esposito, Flavio Stillitano Orgaes, Eliana Aparecida de Rezende Duek
INTRODUCTION: Bioresorbable polymers are often used in medical procedures. Since they are biocompatible, this class of materials is a viable alternative for cases in which tissue regeneration is strongly compromised. Bioresorbable synthetic polymers may be used as membranes to support and guide cell growth through the process of tissue repair. OBJECTIVE: To assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28800637/biologically-active-recombinant-human-erythropoietin-expressed-in-hairy-root-cultures-and-regenerated-plantlets-of-nicotiana-tabacum-l
#16
Poornima Devi Gurusamy, Holger Schäfer, Siva Ramamoorthy, Michael Wink
Hairy root culture is a potential alternative to conventional mammalian cell culture to produce recombinant proteins due to its ease in protein recovery, low costs and absence of potentially human pathogenic contaminants. The current study focussed to develop a new platform of a hairy root culture system from Nicotiana tabacum for the production of recombinant human EPO (rhEPO), which is regularly produced in mammalian cells. The human EPO construct was amplified with C-terminal hexahistidine tag from a cDNA of Caco-2 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28800402/extracellular-matrix-cartilage-allograft-and-particulate-cartilage-allograft-for-osteochondral-lesions-of-the-knee-and-ankle-joints-a-systematic-review
#17
Dexter Seow, Youichi Yasui, Eoghan T Hurley, Andrew W Ross, Christopher D Murawski, Yoshiharu Shimozono, John G Kennedy
BACKGROUND: Extracellular matrix cartilage allografts (EMCAs) and particulate cartilage allografts (PCAs) are relatively new biologics that may improve the quality of cartilage regeneration after bone marrow stimulation. The increasing popularity of these novel biologics in the treatment of osteochondral lesions (OCLs) of the knee and ankle joints prompts a systematic evaluation of their efficacies. PURPOSE: The purpose of this systematic review was to clarify the effectiveness of EMCAs and PCAs on cartilage regeneration...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28800071/fabrication-and-characterization-of-magnesium-ferrite-based-pcl-aloe-vera-nanofibers
#18
Zanshe Thompson, Shekh Rahman, Sergey Yarmolenko, Jagannathan Sankar, Dhananjay Kumar, Narayan Bhattarai
Composite nanofibers of biopolymers and inorganic materials have been widely explored as tissue engineering scaffolds because of their superior structural, mechanical and biological properties. In this study, magnesium ferrite (Mg-ferrite) based composite nanofibers were synthesized using an electrospinning technique. Mg-ferrite nanoparticles were first synthesized using the reverse micelle method, and then blended in a mixture of polycaprolactone (PCL), a synthetic polymer, and Aloe vera, a natural polymer, to create magnetic nanofibers by electrospinning...
August 11, 2017: Materials
https://www.readbyqxmd.com/read/28798872/fiber-reinforced-scaffolds-in-soft-tissue-engineering
#19
REVIEW
Baoqing Pei, Wei Wang, Yubo Fan, Xiumei Wang, Fumio Watari, Xiaoming Li
Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies. Since most of soft tissues in the human body are usually supported by collagen fibers to form a three-dimensional microstructure, fiber-reinforced scaffolds have the advantage to mimic the structure, mechanical and biological environment of natural soft tissues, which benefits for their regeneration and remodeling. This article reviews and discusses the latest research advances on design and manufacture of novel fiber-reinforced scaffolds for soft tissue repair and how fiber addition affects their structural characteristics, mechanical strength and biological activities in vitro and in vivo...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28798690/risk-of-myopathy-in-patients-in-therapy-with-statins-identification-of-biological-markers-in-a-pilot-study
#20
Giulia M Camerino, Olimpia Musumeci, Elena Conte, Kejla Musaraj, Adriano Fonzino, Emanuele Barca, Marco Marino, Carmelo Rodolico, Domenico Tricarico, Claudia Camerino, Maria R Carratù, Jean-François Desaphy, Annamaria De Luca, Antonio Toscano, Sabata Pierno
Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related chloride conductance (gCl). An increase of the activity of protein kinase C theta (PKC theta) isoform, able to inactivate ClC-1, may contribute to destabilize sarcolemma excitability. These effects can be detrimental for muscle function leading to drug-induced myopathy...
2017: Frontiers in Pharmacology
keyword
keyword
61032
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"