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regenerate biology

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https://www.readbyqxmd.com/read/29684623/decoration-of-rgd-mimetic-porous-scaffolds-with-engineered-and-devitalized-extracellular-matrix-for-adipose-tissue-regeneration
#1
Eleonora Rossi, Julien Guerrero, Paola Aprile, Alessandro Tocchio, Elisabeth A Kappos, Cristina Lenardi, Ivan Martin, Arnaud Scherberich
Fat grafting is emerging as a promising alternative to silicon implants in breast reconstruction surgery. Unfortunately, this approach does not provide a proper mechanical support and is affected by drawbacks such as tissue resorption and donor site morbidity. Synthetic scaffolds can offer a valuable alternative to address these challenges, but poorly recapitulate the biochemical stimuli needed for tissue regeneration. Here, we aim at combining the positive features of a structural, synthetic polymer to an engineered, devitalized extracellular matrix (ECM) to generate a hybrid construct that can provide a mix of structural and biological stimuli needed for adipose tissue regeneration...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684504/schwann-cell-plasticity-is-regulated-by-a-weakened-intrinsic-antioxidant-defense-system-in-acute-peripheral-nerve-injury
#2
Wenjing Lv, Binbin Deng, Weisong Duan, Yuanyuan Li, Yakun Liu, Zhongyao Li, Wei Xia, Chunyan Li
The biological effects of the transcription factor NF-E2-related factor 2 (Nrf2) in acute peripheral nervous system (PNS) injury have not been adequately elucidated. By analyzing the results of Nrf2 knockout and Nrf2 activation experiments, we found the following: (1) The antioxidant system was rapidly inactivated after acute PNS injury in a partly Nrf2-dependent manner, giving rise to a temporary state of oxidative stress, and then slowly and partially recovered following regeneration. (2) Nrf2 knockout promoted the reprogramming and proliferation of Schwann cells and inhibited myelination, as well as the redifferentiation of repair Schwann cells...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29682311/acl-reconstruction-with-hamstring-tendon-autograft-and-accelerated-brace-free-rehabilitation-a-systematic-review-of-clinical-outcomes
#3
Rob P A Janssen, Nicky van Melick, Jan B A van Mourik, Max Reijman, Lodewijk W van Rhijn
Objective: To investigate the clinical outcomes after hamstring tendon autograft ACL reconstruction (ACLR) with accelerated, brace-free rehabilitation. Design: Systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Data sources: Embase, MEDLINE Ovid, Web of Science, Cochrane CENTRAL and Google scholar from 1 January 1974 to 31 January 2017. Eligibility criteria for selecting studies: Study designs reporting outcomes in adults after arthroscopic, primary ACLR with hamstring autograft and accelerated, brace-free rehabilitation...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29680723/mineral-trioxide-aggregate-with-mussel-inspired-surface-nanolayers-for-stimulating-odontogenic-differentiation-of-dental-pulp-cells
#4
Ming-Gene Tu, Chia-Che Ho, Tuan-Ti Hsu, Tsui-Hsien Huang, Min-Jhen Lin, Ming-You Shie
INTRODUCTION: This research was intended to evaluate the feasibility of mineral trioxide aggregate (MTA) powder coated with polydopamine (PDA) in dental and bone tissue regeneration by investigating the hydration, physicochemical properties, and biological performance of hydrated cements. METHODS: The MTA powder was well suspended in a dopamine solution buffered at a pH of 8.5 using tris(hydroxymethyl)aminomethane buffer and vigorously stirred for 12 hours at room temperature...
April 18, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29680631/study-on-regeneration-effect-and-mechanism-of-high-frequency-ultrasound-on-biological-activated-carbon
#5
Zhehao Sun, Cheng Liu, Zhen Cao, Wei Chen
High frequency ultrasonic radiation technology was developed as a novel and efficient means of regenerating spent biological activated carbon (BAC) used in drinking water treatment plants (DWTPs). The results of this study indicated that high frequency ultrasonic treatment could recover the spent BAC, to some extent, with the following optimal conditions: a frequency of 400 kHz, sonication power of 60 W, water temperature of 30 °C, and sonication time of 6 min. Under the above conditions, the iodine value increased from 300 mg/g to 409 mg/g, the volume of total pores and micropores increased from 0...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29679318/engineering-citric-acid-based-porous-scaffolds-for-bone-regeneration
#6
Jacqueline J Masehi-Lano, Eun Ji Chung
Tissue engineering aims to develop scaffolds that are biocompatible and mimic the mechanical and biological properties of the target tissue as closely as possible. Here, we describe the fabrication and characterization of a biodegradable, elastomeric porous scaffold: poly(1,8-octanediol-co-citric acid) (POC) incorporated with nanoscale hydroxyapatite (HA). While this chapter focuses on the scaffold's potential for bone regeneration, POC can also be used in other tissue engineering applications requiring an elastomeric implant...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29676520/chip-based-high-resolution-tandem-mass-spectrometric-determination-of-fibroblast-growth-factor-chondroitin-sulfate-disaccharides-noncovalent-interaction
#7
Adrian C Robu, Laurentiu Popescu, Daniela G Seidler, Alina D Zamfir
Fibroblast growth factor-2 (FGF-2) is involved in wound healing and embryonic development. Glycosaminoglycans (GAGs), the major components of the extracellular matrix (ECM), play fundamental roles at this level. FGF-GAG noncovalent interactions are in the focus of research, due to their influence upon cell proliferation and tissue regeneration. Lately, high resolution mass spectrometry (MS) coupled with chip-nanoelectrospray (nanoESI) contributed a significant progress in glycosaminoglycomics by discoveries related to novel species and their characterization...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29675647/fabrication-of-agarose-concave-petridish-for-3d-culture-microarray-method-for-spheroids-formation-of-hepatic-cells
#8
Binbin Zhang, Yang Li, Gaoshang Wang, Zhidong Jia, Haiyan Li, Qing Peng, Yi Gao
Liver is one of the most important organ in the body. But there are many limitations about liver transplantation for liver failure. It is quite important to develop the xenogeneic biological liver for providing an alternation to transplantation or liver regeneration. In this paper, we proposed a method to construct a novel kind of agarose 3D-culture concave microwell array for spheroids formation of hepatic cells. Using the 3D printing method, the microwell array was fabricated with an overall size of 6.4 mm × 6...
April 19, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29674624/brain-and-spinal-cord-injury-repair-by-implantation-of-human-neural-progenitor-cells-seeded-onto-polymer-scaffolds
#9
Jeong Eun Shin, Kwangsoo Jung, Miri Kim, Kyujin Hwang, Haejin Lee, Il-Sun Kim, Bae Hwan Lee, Il-Shin Lee, Kook In Park
Hypoxic-ischemic (HI) brain injury and spinal cord injury (SCI) lead to extensive tissue loss and axonal degeneration. The combined application of the polymer scaffold and neural progenitor cells (NPCs) has been reported to enhance neural repair, protection and regeneration through multiple modes of action following neural injury. This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into the infarction cavity of a neonatal HI brain injury or the hemisection cavity in an adult SCI...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29674432/cell-type-atlas-and-lineage-tree-of-a-whole-complex-animal-by-single-cell-transcriptomics
#10
Mireya Plass, Jordi Solana, F Alexander Wolf, Salah Ayoub, Aristotelis Misios, Petar Glažar, Benedikt Obermayer, Fabian J Theis, Christine Kocks, Nikolaus Rajewsky
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate to all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from the transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment...
April 19, 2018: Science
https://www.readbyqxmd.com/read/29673841/electrospun-silk-fibroin-fibers-for-storage-and-controlled-release-of-human-platelet-lysate
#11
Cataldo Pignatelli, Giovanni Perotto, Marta Nardini, Ranieri Cancedda, Maddalena Mastrogiacomo, Athanassia Athanassiou
Human platelet lysate (hPL) is a pool of growth factors and cytokines able to induce regeneration of different tissues. Despite its good potentiality as therapeutic tool for regenerative medicine applications, hPL has been only moderately exploited in this field. A more widespread adoption has been limited because of its rapid degradation at room temperature that decreases its functionality. Another limiting factor for its extensive use is the difficulty of handling the hPL gels. In this work, silk fibroin-based patches were developed to address several points: improving the handling of hPL, enabling their delivery in a controlled manner and facilitating their storage by creating a device ready to use with expanded shelf life...
April 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29670253/cryopreservation-of-fish-spermatogonial-cells-the-future-of-natural-history-collections
#12
Mary M Hagedorn, Jonathan P Daly, Virginia L Carter, Kathleen S Cole, Zeehan Jaafar, Claire V A Lager, Lynne R Parenti
As global biodiversity declines, the value of biological collections increases. Cryopreserved diploid spermatogonial cells meet two goals: to yield high-quality molecular sequence data; and to regenerate new individuals, hence potentially countering species extinction. Cryopreserved spermatogonial cells that allow for such mitigative measures are not currently in natural history museum collections because there are no standard protocols to collect them. Vertebrate specimens, especially fishes, are traditionally formalin-fixed and alcohol-preserved which makes them ideal for morphological studies and as museum vouchers, but inadequate for molecular sequence data...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670035/three-dimensional-architecture-and-mechanical-properties-of-bovine-bone-mixed-with-autologous-platelet-liquid-blood-or-physiological-water-an-in-vitro-study
#13
Antonio Scarano, Francesco Inchingolo, Giovanna Murmura, Tonino Traini, Adriano Piattelli, Felice Lorusso
In recent years, several techniques and material options have been investigated and developed for bone defect repair and regeneration. The progress in studies of composite graft materials and autologous platelet-derived growth factors for bone regeneration in dentistry and their biological and biomechanical properties has improved clinical strategies and results. The aim of this study was to evaluate the three-dimensional architecture and mechanical properties of three different combinations of composite bovine graft, adding autologous platelet liquid (APL), blood, or physiological water...
April 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29667905/essential-role-of-mohawk-for-tenogenic-tissue-homeostasis-including-spinal-disc-and-periodontal-ligament
#14
Ryo Nakamichi, Kensuke Kataoka, Hiroshi Asahara
Tendons and ligaments play essential roles in connecting muscle and bone and stabilizing the connections between bones. The damage to tendons and ligaments caused by aging, injury, and arthritis induces the dysfunction of the musculoskeletal system and reduces the quality of life. Current therapy for damaged tendons and ligaments depends on self-repair; however, it is difficult to reconstruct normal tissue. Regeneration therapy for tendons and ligaments has not been achieved, partly because the mechanism, cell biology, and pathophysiology of tendon and ligament development remain unclear...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29667005/the-bmp-2-mutant-l51p-a-bmp-receptor-ia-binding-deficient-inhibitor-of-noggin
#15
REVIEW
Hany Mohamed Khattab, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki, Walter Sebald
The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the natural biological response of the natural body growth factors. L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue. L51P is deficient in BMP receptor binding, but maintains its structure and affinity for inhibitory proteins such as noggin, chordin, and gremlin. These modifications convert the BMP-2 variant L51P into a receptor-inactive inhibitor of BMP antagonists...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29666616/stem-cell-transcription-factor-foxo-controls-microbiome-resilience-in-hydra
#16
Benedikt M Mortzfeld, Jan Taubenheim, Sebastian Fraune, Alexander V Klimovich, Thomas C G Bosch
The aging process is considered to be the result of accumulating cellular deterioration in an individual organism over time. It can be affected by the combined influence of genetic, epigenetic, and environmental factors including life-style-associated events. In the non-senescent freshwater polyp Hydra , one of the classical model systems for evolutionary developmental biology and regeneration, transcription factor FoxO modulates both stem cell proliferation and innate immunity. This provides strong support for the role of FoxO as a critical rate-of-aging regulator...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29666392/synthetic-9-cis-beta-carotene-inhibits-photoreceptor-degeneration-in-cultures-of-eye-cups-from-rpe65rd12-mouse-model-of-retinoid-cycle-defect
#17
Ifat Sher, Adi Tzameret, Sara Peri-Chen, Victoria Edelshtain, Michael Ioffe, Alon Sayer, Ludmila Buzhansky, Ehud Gazit, Ygal Rotenstreich
The retinoid cycle enzymes regenerate the visual chromophore 11-cis retinal to enable vision. Mutations in the genes encoding the proteins of the retinoid cycle are the leading cause for recessively inherited retinal dystrophies such as retinitis pigmentosa, Leber congenital amaurosis, congenital cone-rod dystrophy and fundus albipunctatus. Currently there is no treatment for these blinding diseases. In previous studies we demonstrated that oral treatment with the 9-cis-β-carotene rich Dunaliella Bardawil algae powder significantly improved visual and retinal functions in patients with retinitis pigmentosa and fundus albipunctatus...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665454/comparison-of-the-mechanobiological-performance-of-bone-tissue-scaffolds-based-on-different-unit-cell-geometries
#18
Óscar L Rodríguez-Montaño, Carlos Julio Cortés-Rodríguez, Antonio E Uva, Michele Fiorentino, Michele Gattullo, Giuseppe Monno, Antonio Boccaccio
Enhancing the performance of scaffolds for bone regeneration requires a multidisciplinary approach involving competences in the fields of Biology, Medicine and Engineering. A number of studies have been conducted to investigate the influence of scaffolds design parameters on their mechanical and biological response. The possibilities offered by the additive manufacturing techniques to fabricate sophisticated and very complex microgeometries that until few years ago were just a geometrical abstraction, led many researchers to design scaffolds made from different unit cell geometries...
April 11, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29665330/design-and-applications-of-cell-selective-surfaces-and-interfaces
#19
Haolan Zhang, Xiaowen Zheng, Wajiha Ahmed, Yuejun Yao, Jun Bai, Yicheng Chen, Changyou Gao
Tissue regeneration involves versatile kinds of cells. The accumulation and disorganized behaviors of undesired cells impair natural healing process, leading to uncontrolled immune response, restenosis, and/or fibrosis. The cell-selective surfaces and interfaces can have specific and positive effects to the desired types of cells, allowing tissue regeneration with restored structures and functions. This review outlines the importance of surfaces and interfaces of biomaterials with cell-selective properties...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29664609/using-an-engineered-galvanic-redox-system-to-generate-positive-surface-potentials-that-promote-osteogenic-functions
#20
Yulong Zhang, Zhong Zheng, Mengliu Yu, Chinyun Hsu, Emily Berthiaume, Hsinchuan Pan, Xinli Zhang, Adam Z Stieg, Benjamin Wu, Huiming Wang, Kang Ting, Chia Soo
Successful osseointegration of orthopaedic and orthodontic implants is dependent on a competition between osteogenesis and bacterial contamination on the implant-tissue interface. Previously, by taking advantage of the highly interactive capabilities of silver nanoparticles (AgNPs), we effectively introduced an antimicrobial effect to metal implant materials using a AgNP/poly(DL-lactic-co-glycolic acid) (PLGA) coating. Although electrical forces have been shown to promote osteogenesis, creating practical materials and devices capable of harnessing these forces to induce bone regeneration remains challenging...
April 17, 2018: ACS Applied Materials & Interfaces
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