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https://www.readbyqxmd.com/read/29769073/measuring-bothersome-menopausal-symptoms-development-and-validation-of-the-menoscores-questionnaire
#1
Kamma Sundgaard Lund, Volkert Dirk Siersma, Karl Bang Christensen, Frans Boch Waldorff, John Brodersen
BACKGROUND: The experience of menopausal symptoms is common and an adequate patient-reported outcome measure is crucial in studies where women are treated for these symptoms. The aims of this study were to identify a patient-reported outcome measure for bothersome menopausal symptoms and, in the absence of an adequate tool, to develop a new measure with high content validity, and to validate it using modern psychometric methods. METHODS: The literature was reviewed for existing questionnaires and checklists for bothersome menopausal symptoms...
May 16, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29749912/comparative-durability-and-costs-analysis-of-ventricular-shunts
#2
Nitin Agarwal, Ahmed Kashkoush, Michael M McDowell, William R Lariviere, Naveed Ismail, Robert M Friedlander
OBJECTIVE Ventricular shunt (VS) durability has been well studied in the pediatric population and in patients with normal pressure hydrocephalus; however, further evaluation in a more heterogeneous adult population is needed. This study aims to evaluate the effect of diagnosis and valve type-fixed versus programmable-on shunt durability and cost for placement of shunts in adult patients. METHODS The authors retrospectively reviewed the medical records of all patients who underwent implantation of a VS for hydrocephalus at their institution over a 3-year period between August 2013 and October 2016 with a minimum postoperative follow-up of 6 months...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29746616/a-regulatory-insertion-deletion-polymorphism-in-the-fads-gene-cluster-influences-pufa-and-lipid-profiles-among-chinese-adults-a-population-based-study
#3
Peiqin Li, Jing Zhao, Kumar S D Kothapalli, Xiang Li, Hui Li, Yuxuan Han, Shengquan Mi, Wenhua Zhao, Qizhai Li, Hong Zhang, Yiqing Song, J Thomas Brenna, Ying Gao
Background: Arachidonic acid (AA) is the major polyunsaturated fatty acid (PUFA) substrate for potent eicosanoid signaling to modulate inflammation and thrombosis and is controlled in part by tissue abundance. Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-3) AA and n-3 eicosapentaenoic acid (EPA). The rs66698963 polymorphism, a 22-base pair (bp) insertion-deletion 137 bp downstream of a sterol regulatory element in FADS2 intron 1, mediates expression of FADS1 in vitro, as well as exerting positive selection in several human populations...
May 9, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29729568/bioaccumulation-of-microcystin-congeners-in-soil-plant-system-and-human-health-risk-assessment-a-field-study-from-lake-taihu-region-of-china
#4
Qing Cao, Alan D Steinman, Xiang Wan, Liqiang Xie
A 120-day field study was carried out near Lake Taihu to evaluate the bioaccumulation of microcystin (MC) congeners in a soil-plant system, as well as to assess human health risk when consuming edible plants irrigated with MCs-contaminated water. Natural cyanobacteria bloom-containing lake water (lake water) and half-diluted natural cyanobacteria bloom-containing lake water with tap water (half-lake water) were used to irrigate lettuce and rice. An additional treatment involving fertilization with a cyanobacteria bloom was applied just to the lettuce experiment...
May 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29712529/cost-effectiveness-development-for-the-postoperative-care-of-craniotomy-patients-a-safe-transitions-pathway-in-neurological-surgery
#5
Joseph A Osorio, Michael M Safaee, Jennifer Viner, Sujatha Sankaran, Sarah Imershein, Ezekiel Adigun, Gabriela Weigel, Mitchel S Berger, Michael W McDermott
OBJECTIVE The authors' institution is in the top 5th percentile for hospital cost in the nation, and the neurointensive care unit (NICU) is one of the costliest units. The NICU is more expensive than other units because of lower staff/patient ratio and because of the equipment necessary to monitor patient care. The cost differential between the NICU and Neuro transitional care unit (NTCU) is $1504 per day. The goal of this study was to evaluate and to pilot a program to improve efficiency and lower cost by modifying the postoperative care of patients who have undergone a craniotomy, sending them to the NTCU as opposed to the NICU...
May 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29690878/efficacy-and-safety-of-methylene-blue-in-the-treatment-of-malaria-a-systematic-review
#6
G Lu, M Nagbanshi, N Goldau, M Mendes Jorge, P Meissner, A Jahn, F P Mockenhaupt, O Müller
BACKGROUND: Methylene blue (MB) was the first synthetic antimalarial to be discovered and was used during the late 19th and early 20th centuries against all types of malaria. MB has been shown to be effective in inhibiting Plasmodium falciparum in culture, in the mouse model and in rhesus monkeys. MB was also shown to have a potent ex vivo activity against drug-resistant isolates of P. falciparum and P. vivax. In preclinical studies, MB acted synergistically with artemisinin derivates and demonstrated a strong effect on gametocyte reduction in P...
April 25, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29671826/urinary-cotinine-concentration-and-self-reported-smoking-status-in-1075-subjects-living-in-central-italy
#7
Enrico Paci, Daniela Pigini, Lisa Bauleo, Carla Ancona, Francesco Forastiere, Giovanna Tranfo
Background: Urinary cotinine, a metabolite of nicotine, is a marker of tobacco smoke exposure. A cutoff value for cotinine concentration can be set to distinguish smokers from non-smokers, independently from self-declared status. Method: Cotinine was determined by isotopic dilution High Performance Liquid Chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) between 2013 and 2014 on urine samples of a population of 1075 subjects. Results : 296 subjects have a cotinine level higher than 100 μg/g of creatinine (cutoff), with a median cotinine concentration of 1504...
April 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29657426/status-of-theileriosis-among-herbivores-in-iran-a-systematic-review-and-meta-analysis
#8
Masoud Soosaraei, Mousa Motavalli Haghi, Fariborz Etemadifar, Mahdi Fakhar, Saeed Hosseini Teshnizi, Hajar Ziaei Hezarjaribi, Shabnam Asfaram
Aim: Theileriosis is a protozoal disease caused by Theileria spp. mostly in warm-blooded vertebrates worldwide. It is one of the common tick-borne diseases among domestic animals in tropical and sub-tropical regions, which have a variety of unlikable effects on health economy and animal welfare. In the present study, the prevalence of theileriosis among domestic farm animals in Iran was systematically evaluated. Methods: To identify the related papers, 10 English and Persian databases, including PubMed, Science Direct, Scopus, Web of Science, Medical Subject Headings, Google Scholar, Magiran, Barakatns (formerly Iranmedex), Elm net, and Scientific Information Database, were appraised for articles published throughout 1999-2017...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29642510/dietary-patterns-associated-with-cognitive-function-among-the-older-people-in-underdeveloped-regions-finding-from-the-ncdfac-study
#9
Zhaoxue Yin, Jing Chen, Jian Zhang, Zeping Ren, Kui Dong, Virginia B Kraus, Zhuoqun Wang, Mei Zhang, Yi Zhai, Pengkun Song, Yanfang Zhao, Shaojie Pang, Shengquan Mi, Wenhua Zhao
Although dietary patterns are crucial to cognitive function, associations of dietary patterns with cognitive function have not yet been fully understood. This cross-sectional study explored dietary patterns associated with cognitive function among the older adults in underdeveloped regions, using 1504 community-dwelling older adults aged 60 and over. Diet was assessed using a food frequency questionnaire and 24-h dietary recall. Factor analysis was used to extract dietary patterns. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE)...
April 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29501268/significant-association-between-opg-tnfrsf11b-variant-and-common-complex-ischemic-stroke
#10
Xin Xiong, Duraid Hamied Naji, Binbin Wang, Yuanyuan Zhao, Junhan Wang, Dan Wang, Yuting Zhang, Sisi Li, Shanshan Chen, Yufeng Huang, Qin Yang, Xiaojing Wang, Dan Yin, Xin Tu, Qiuyun Chen, Xu Ma, Chengqi Xu, Qing K Wang
BACKGROUND: The serum level of osteoprotegerin (encoded by OPG or TNFRSF11B) was previously shown to be increased in patients with ischemic stroke. A single nucleotide polymorphism rs3134069 in the TNFRSF11B gene was previously associated with ischemic stroke in a population of diabetic patients in Italy. It remains to be determined whether rs3134069 is associated with ischemic stroke in the general population or populations without diabetes. MATERIALS AND METHODS: We genotyped rs3134069 and performed a case-control association study to test whether rs3134069 is associated with ischemic stroke in 2 independent Chinese Han populations, including a China-Central population with 1629 cases and 1504 controls and a China-Northern population with 1206 cases and 720 controls...
June 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29470626/living-donor-liver-transplantation-post-operative-imaging-follow-up-of-right-lobe-liver-donors
#11
Tapas K Tejura, Alejandro Pita, Christian Romero, Yuri S Genyk, Linda Sher, Suzanne L Palmer
PURPOSE: To identify long-term post-operative imaging findings resulting from right lobe liver donation. METHODS: This retrospective imaging review consisted of 42 adults (20 males, 22 females, mean age 36.6 years, range 18.7-55.9 years) who underwent right lobe liver donation with pre- and post-operative imaging between 1999 and 2006. The mean follow-up period was 30.2 months (range 12.3-69.6 months). Follow-up imaging evaluation included assessment of the biliary tree, particularly isolated bile ducts draining to and terminating at the cut surface (orphan ducts)...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29447837/analyses-of-the-molecular-mechanisms-associated-with-salinity-adaption-of-trachidermus-fasciatus-through-combined-itraq-based-proteomics-and-rna-sequencing-based-transcriptomics
#12
REVIEW
Qian Ma, Xinfu Liu, Wenrong Feng, Shufang Liu, Zhimeng Zhuang
Osmoregulation mechanism underlying acclimation and adaptation of migratory fish to different salinities has been studied for decades. Recently developed transcriptomic and proteomic techniques would make it possible to provide more reliable data to decipher the mechanism study at a molecular level. Here in this study, an integrative analysis of the kidney-specific transcriptome and proteome was performed to identify important regulators and pathways involved in salinity adaption of roughskin sculpin (Trachidermus fasciatus)...
February 12, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29447344/the-balance-between-short-term-and-long-term-outcomes-of-bilateral-internal-thoracic-artery-skeletonization-in-coronary-artery-bypass-surgery-a-propensity-matched-cohort-study
#13
Janet M C Ngu, Ming Hao Guo, David Glineur, Diem Tran, Fraser D Rubens
OBJECTIVES: There is growing interest in the use of bilateral internal thoracic arteries (BITAs) for myocardial revascularization. This study sought to compare the balance between early benefits and long-term outcomes of skeletonized or non-skeletonized conduits and to determine whether differences in outcomes are affected by other patient risk factors. METHODS: BITAs were used in 1504 cases with either SK or NSK conduits. Propensity matching was completed using 22 covariates identifying 441 pairs of patients...
February 13, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29433958/an-ontology-driven-clinical-decision-support-system-iddap-for-infectious-disease-diagnosis-and-antibiotic-prescription
#14
Ying Shen, Kaiqi Yuan, Daoyuan Chen, Joël Colloc, Min Yang, Yaliang Li, Kai Lei
BACKGROUND: The available antibiotic decision-making systems were developed from a physician's perspective. However, because infectious diseases are common, many patients desire access to knowledge via a search engine. Although the use of antibiotics should, in principle, be subject to a doctor's advice, many patients take them without authorization, and some people cannot easily or rapidly consult a doctor. In such cases, a reliable antibiotic prescription support system is needed. METHODS AND RESULTS: This study describes the construction and optimization of the sensitivity and specificity of a decision support system named IDDAP, which is based on ontologies for infectious disease diagnosis and antibiotic therapy...
March 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29429066/outcomes-following-surgical-management-of-femoral-neck-fractures-in-elderly-dialysis-dependent-patients
#15
Varun Puvanesarajah, Raj Amin, Rabia Qureshi, Babar Shafiq, Ben Stein, Hamid Hassanzadeh, Seth Yarboro
INTRODUCTION: Proximal femur fractures are one of the most common fractures observed in dialysis-dependent patients. Given the large comorbidity burden present in this patient population, more information is needed regarding post-operative outcomes. The goal of this study was to assess morbidity and mortality following operative fixation of femoral neck fractures in the dialysis-dependent elderly. METHODS: The full set of medicare data from 2005 to 2014 was retrospectively analyzed...
February 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29381605/novel-ptch1-gene-mutation-in-nevoid-basal-cell-carcinoma-syndrome
#16
Yookyeong Carolyn Sim, Gu-Hwan Kim, Sung-Weon Choi, Kang-Min Ahn
The purpose of this study was to report clinical characteristics, surgical results, and new PTCH1 gene mutations in nevoid basal cell carcinoma syndrome (NBCCS). Five patients were referred to the Department of Oral and Maxillofacial Surgery from local dental clinics between 2006 and 2016 to treat multiple keratocystic odontogenic tumors (KOTs). The cystic lesions were enucleated and peripheral ostectomy was performed to obtain safety margin. Recurrence and/or de novo development of KOT were assessed. Gene analysis using peripheral blood was performed in all patients to identify the mutation of PTCH1 gene...
January 29, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29330033/service-quality-and-parents-willingness-to-get-adolescents-hpv-vaccine-from-pharmacists
#17
Parth D Shah, William A Calo, Macary W Marciniak, Carol E Golin, Betsy L Sleath, Noel T Brewer
We sought to examine whether pharmacy service quality was associated with parents' willingness to have immunizing pharmacists administer human papillomavirus (HPV) vaccine to their adolescent children. Participants were a national sample of 1504 US parents of adolescents ages 11 to 17 who completed an online survey in 2014. Analyses used structural equation modeling. Parents rated service quality and feelings of satisfaction with their pharmacies as moderate to high. Many (44%) were willing to get HPV vaccine from immunizing pharmacists for their adolescent children...
April 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29315408/birth-order-and-number-of-siblings-and-their-association-with-overweight-and-obesity-a-systematic-review-and-meta-analysis
#18
Fernanda Oliveira Meller, Christian Loret de Mola, Maria Cecília Formoso Assunção, Antônio Augusto Schäfer, Darren Lawrence Dahly, Fernando Celso Barros
Context: The effect of both birth order and number of siblings on overweight and/or obesity has not been determined. Birth order and sibsize have been mathematically coupled to overweight and/or obesity, but thus far their respective effects have been estimated separately. Objective: The aim of this systematic review was to evaluate the effects of both birth order and number of siblings on the risk of overweight/obesity. Data Sources: The electronic databases MEDLINE, Social Science, SocINDEX, PsycINFO, CINAHL Plus, and Academic Search Complete were searched systematically...
February 1, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29242041/long-term-outcomes-for-neoadjuvant-versus-adjuvant-chemotherapy-in-early-breast-cancer-meta-analysis-of-individual-patient-data-from-ten-randomised-trials
#19
(no author information available yet)
BACKGROUND: Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials. METHODS: We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively...
January 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29198507/british-society-for-sexual-medicine-guidelines-on-adult-testosterone-deficiency-with-statements-for-uk-practice
#20
REVIEW
Geoff Hackett, Michael Kirby, David Edwards, Thomas Hugh Jones, Kevan Wylie, Nick Ossei-Gerning, Janine David, Asif Muneer
BACKGROUND: Testosterone deficiency (TD) is an increasingly common problem with significant health implications, but its diagnosis and management can be challenging. AIM: To review the available literature on TD and provide evidence-based statements for UK clinical practice. METHODS: Evidence was derived from Medline, EMBASE, and Cochrane searches on hypogonadism, testosterone (T) therapy, and cardiovascular safety from May 2005 to May 2015...
December 2017: Journal of Sexual Medicine
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