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Xin Xiong, Duraid Hamied Naji, Binbin Wang, Yuanyuan Zhao, Junhan Wang, Dan Wang, Yuting Zhang, Sisi Li, Shanshan Chen, Yufeng Huang, Qin Yang, Xiaojing Wang, Dan Yin, Xin Tu, Qiuyun Chen, Xu Ma, Chengqi Xu, Qing K Wang
BACKGROUND: The serum level of osteoprotegerin (encoded by OPG or TNFRSF11B) was previously shown to be increased in patients with ischemic stroke. A single nucleotide polymorphism rs3134069 in the TNFRSF11B gene was previously associated with ischemic stroke in a population of diabetic patients in Italy. It remains to be determined whether rs3134069 is associated with ischemic stroke in the general population or populations without diabetes. MATERIALS AND METHODS: We genotyped rs3134069 and performed a case-control association study to test whether rs3134069 is associated with ischemic stroke in 2 independent Chinese Han populations, including a China-Central population with 1629 cases and 1504 controls and a China-Northern population with 1206 cases and 720 controls...
February 28, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Tapas K Tejura, Alejandro Pita, Christian Romero, Yuri S Genyk, Linda Sher, Suzanne L Palmer
PURPOSE: To identify long-term post-operative imaging findings resulting from right lobe liver donation. METHODS: This retrospective imaging review consisted of 42 adults (20 males, 22 females, mean age 36.6 years, range 18.7-55.9 years) who underwent right lobe liver donation with pre- and post-operative imaging between 1999 and 2006. The mean follow-up period was 30.2 months (range 12.3-69.6 months). Follow-up imaging evaluation included assessment of the biliary tree, particularly isolated bile ducts draining to and terminating at the cut surface (orphan ducts)...
February 22, 2018: Abdominal Radiology
Qian Ma, Xinfu Liu, Wenrong Feng, Shufang Liu, Zhimeng Zhuang
Osmoregulation mechanism underlying acclimation and adaptation of migratory fish to different salinities has been studied for decades. Recently developed transcriptomic and proteomic techniques would make it possible to provide more reliable data to decipher the mechanism study at a molecular level. Here in this study, an integrative analysis of the kidney-specific transcriptome and proteome was performed to identify important regulators and pathways involved in salinity adaption of roughskin sculpin (Trachidermus fasciatus)...
February 12, 2018: Progress in Biophysics and Molecular Biology
Janet M C Ngu, Ming Hao Guo, David Glineur, Diem Tran, Fraser D Rubens
OBJECTIVES: There is growing interest in the use of bilateral internal thoracic arteries (BITAs) for myocardial revascularization. This study sought to compare the balance between early benefits and long-term outcomes of skeletonized or non-skeletonized conduits and to determine whether differences in outcomes are affected by other patient risk factors. METHODS: BITAs were used in 1504 cases with either SK or NSK conduits. Propensity matching was completed using 22 covariates identifying 441 pairs of patients...
February 13, 2018: European Journal of Cardio-thoracic Surgery
Ying Shen, Kaiqi Yuan, Daoyuan Chen, Joël Colloc, Min Yang, Yaliang Li, Kai Lei
BACKGROUND: The available antibiotic decision-making systems were developed from a physician's perspective. However, because infectious diseases are common, many patients desire access to knowledge via a search engine. Although the use of antibiotics should, in principle, be subject to a doctor's advice, many patients take them without authorization, and some people cannot easily or rapidly consult a doctor. In such cases, a reliable antibiotic prescription support system is needed. METHODS AND RESULTS: This study describes the construction and optimization of the sensitivity and specificity of a decision support system named IDDAP, which is based on ontologies for infectious disease diagnosis and antibiotic therapy...
February 9, 2018: Artificial Intelligence in Medicine
Varun Puvanesarajah, Raj Amin, Rabia Qureshi, Babar Shafiq, Ben Stein, Hamid Hassanzadeh, Seth Yarboro
INTRODUCTION: Proximal femur fractures are one of the most common fractures observed in dialysis-dependent patients. Given the large comorbidity burden present in this patient population, more information is needed regarding post-operative outcomes. The goal of this study was to assess morbidity and mortality following operative fixation of femoral neck fractures in the dialysis-dependent elderly. METHODS: The full set of medicare data from 2005 to 2014 was retrospectively analyzed...
February 10, 2018: Archives of Orthopaedic and Trauma Surgery
Yookyeong Carolyn Sim, Gu-Hwan Kim, Sung-Weon Choi, Kang-Min Ahn
The purpose of this study was to report clinical characteristics, surgical results, and new PTCH1 gene mutations in nevoid basal cell carcinoma syndrome (NBCCS). Five patients were referred to the Department of Oral and Maxillofacial Surgery from local dental clinics between 2006 and 2016 to treat multiple keratocystic odontogenic tumors (KOTs). The cystic lesions were enucleated and peripheral ostectomy was performed to obtain safety margin. Recurrence and/or de novo development of KOT were assessed. Gene analysis using peripheral blood was performed in all patients to identify the mutation of PTCH1 gene...
January 29, 2018: Journal of Craniofacial Surgery
Parth D Shah, William A Calo, Macary W Marciniak, Carol E Golin, Betsy L Sleath, Noel T Brewer
We sought to examine whether pharmacy service quality was associated with parents' willingness to have immunizing pharmacists administer human papillomavirus (HPV) vaccine to their adolescent children. Participants were a national sample of 1504 US parents of adolescents ages 11 to 17 who completed an online survey in 2014. Analyses used structural equation modeling. Parents rated service quality and feelings of satisfaction with their pharmacies as moderate to high. Many (44%) were willing to get HPV vaccine from immunizing pharmacists for their adolescent children...
January 9, 2018: Preventive Medicine
Fernanda Oliveira Meller, Christian Loret de Mola, Maria Cecília Formoso Assunção, Antônio Augusto Schäfer, Darren Lawrence Dahly, Fernando Celso Barros
Context: The effect of both birth order and number of siblings on overweight and/or obesity has not been determined. Birth order and sibsize have been mathematically coupled to overweight and/or obesity, but thus far their respective effects have been estimated separately. Objective: The aim of this systematic review was to evaluate the effects of both birth order and number of siblings on the risk of overweight/obesity. Data Sources: The electronic databases MEDLINE, Social Science, SocINDEX, PsycINFO, CINAHL Plus, and Academic Search Complete were searched systematically...
February 1, 2018: Nutrition Reviews
(no author information available yet)
BACKGROUND: Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials. METHODS: We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively...
December 11, 2017: Lancet Oncology
Geoff Hackett, Michael Kirby, David Edwards, Thomas Hugh Jones, Kevan Wylie, Nick Ossei-Gerning, Janine David, Asif Muneer
BACKGROUND: Testosterone deficiency (TD) is an increasingly common problem with significant health implications, but its diagnosis and management can be challenging. AIM: To review the available literature on TD and provide evidence-based statements for UK clinical practice. METHODS: Evidence was derived from Medline, EMBASE, and Cochrane searches on hypogonadism, testosterone (T) therapy, and cardiovascular safety from May 2005 to May 2015...
December 2017: Journal of Sexual Medicine
Jing Xia, Ke-Chang Yao, Yue-Yue Liu, Guo-Jin You, Su-Yun Li, Ping Liu, Qin Zhao, Yi-Ping Wen Rui Wu, Xiao-Bo Huang, San-Jie Cao, Xin-Feng Han, Yong Huang
Fowl adenovirus (FAdV) has caused significant losses in chicken flocks throughout China in recent years. However, the current understanding of the genetic and pathogenic characteristics of the FAdV epidemic in southwestern China remains poorly understood. In this study, a total of 22 strains were isolated from liver samples of diseased chickens from farms in southwestern China. Phylogenetic analysis based on the hexon loop-1 gene showed that the 22 isolates were clustered into four distinct serotypes: FAdV serotype 4 (FAdV-4) (86...
November 29, 2017: Emerging Microbes & Infections
José M Lorenzo, Rubén Agregán, Paulo E S Munekata, Daniel Franco, Javier Carballo, Selin Şahin, Ramón Lacomba, Francisco J Barba
Proximate composition (moisture, protein, lipid and ash content) and nutritional value (fatty acid, amino acid and mineral profile) of three macroalgae ( Ascophyllum nodosum , Fucus vesiculosus and Bifurcaria bifurcate ) were studied. Chemical composition was significantly ( p < 0.001) different among the three seaweeds. In this regard, the B. bifurcata presented the highest fat content (6.54% of dry matter); whereas, F. vesiculosus showed the highest protein level (12.99% dry matter). Regarding fatty acid content, the polyunsaturated fatty acids (PUFAs) were the most abundant followed by saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs)...
November 15, 2017: Marine Drugs
Chris T Longenecker, Stephen R Morris, Twalib O Aliku, Andrea Beaton, Marco A Costa, Moses R Kamya, Cissy Kityo, Peter Lwabi, Grace Mirembe, Dorah Nampijja, Joselyn Rwebembera, Craig Sable, Robert A Salata, Amy Scheel, Daniel I Simon, Isaac Ssinabulya, Emmy Okello
BACKGROUND: Rheumatic heart disease (RHD) is a leading cause of premature death and disability in low-income countries; however, few receive optimal benzathine penicillin G (BPG) therapy to prevent disease progression. We aimed to comprehensively describe the treatment cascade for RHD in Uganda to identify appropriate targets for intervention. METHODS AND RESULTS: Using data from the Uganda RHD Registry (n=1504), we identified the proportion of patients in the following care categories: (1) diagnosed and alive as of June 1, 2016; (2) retained in care; (3) appropriately prescribed BPG; and (4) optimally adherent to BPG (>80% of prescribed doses)...
November 2017: Circulation. Cardiovascular Quality and Outcomes
Cristiane Jeyce Gomes-Lima, Di Wu, Pejman H Kharazi, Gauri Khorjekar, Matthew D Ringel, Richard J Vetter, Gary Bloom, Kenneth D Burman, Leonard Wartofsky, Douglas Van Nostrand
BACKGROUND: Whether <sup>131</sup>I treatments for differentiated thyroid cancer (DTC) should be performed as an outpatient or inpatient remains controversial. The objective of this study was to survey selected aspects of radiation safety of patients treated with <sup>131</sup>I for DTC as an outpatient. METHODS: An e-mail invitation was sent to over 15,000 members of ThyCa: Thyroid Cancer Survivors' Association, Inc. to complete a web-based survey on selected aspects of radiation safety regarding their last outpatient <sup>131</sup>I treatment...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
Heather Tulloch, Adam Heenan, Laura Cupper, Robert Pelletier, Pat OʼFarrell, Andrew Pipe
PURPOSE: Best practice guidelines for cardiac rehabilitation (CR) suggest routine screening for anxiety and depression, yet many patients are not screened nor do they receive mental health treatment. Protocols are required to identify those in need of care and to ensure that appropriate assistance is provided. METHODS: Consecutive patients entering CR in our setting from May 4, 2012, to May 3, 2013, completed the Hospital Anxiety and Depression Scale (HADS). As per our Screening and Triage protocol for Anxiety and Depression (STAD), patients with high scores (≥16) were referred to a clinical psychologist; those with low scores (<8 for depression and <11 for anxiety) received information about community resources...
November 7, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
Gerhard Aumüller
Landgrave Philipp of Hesse was one of the leading figures of the reformation period. His morganatic marriage to a young Saxonian lady resulted in a massive impairment of his importance and initiated the division of his territory among his four legitimate sons. Triorchidism ascribed to him was more likely a misdiagnosed spermatozele, and also, there is no reliable account for his syphilis infection. The foundation of the Hessian Grand Hospitals, housing the poor, sick and disabled from the countryside, was his major social-medical achievement...
November 6, 2017: Der Urologe. Ausg. A
Xuying Wang, Jiageng Chen, Xiaoqian Liu, Fei Gao, Haozuo Zhao, Duolan Han, Xiyue Jing, Yuanyuan Liu, Zhuang Cui, Changping Li, Jun Ma
INTRODUCTION: Lifestyle behaviors are essential elements of diabetes care. The aims of this study were to identify distinct subgroups of people with type 2 diabetes based on personal levels of lifestyle behaviors and explore the different characteristics across these subgroups. METHODS: In 2015 and 2016, 1504 outpatients with a diagnosis of type 2 diabetes were selected via two-stage simple random sampling from 10 municipal district hospitals in Tianjin. Participants accepted an invitation by experienced physicians to complete a questionnaire containing demographic and lifestyle content...
December 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Guillaume Carteaux, Damien Contou, Guillaume Voiriot, Antoine Khalil, Marie-France Carette, Martine Antoine, Antoine Parrot, Muriel Fartoukh
PURPOSE: Severe hemoptysis (SH) associated with non-tuberculosis bacterial lower respiratory tract infection (LRTI) is poorly described, and the efficacy of the usual decision-making process is unknown. This study aimed at describing the clinical, radiological patterns, mechanism, and microbiological spectrum of SH related to bacterial LRTI, and assessing whether the severity of hemoptysis and the results of usual therapeutic strategy are influenced by the presence of parenchymal necrosis...
October 12, 2017: Lung
Oumy Niass, Philippe Saint-Pierre, Makhtar Niang, Fode Diop, Babacar Diouf, Michel Matar Faye, Fatoumata Diène Sarr, Joseph Faye, Nafissatou Diagne, Cheikh Sokhna, Jean-François Trape, Ronald Perraut, Adama Tall, Abdou Kâ Diongue, Aïssatou Toure Balde
BACKGROUND: Evaluation of local Plasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate seroconversion rates. High correlations were observed between seroconversion rates and entomological inoculation rates (EIR). However, in this model, the effects of malaria control interventions and clinical episodes on serological measurements were not assessed. This study monitors the use of antibody responses to P...
October 11, 2017: Malaria Journal
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