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https://www.readbyqxmd.com/read/28544661/early-passage-mesenchymal-stem-cells-display-decreased-radiosensitivity-and-increased-dna-repair-activity
#1
Po-Kuei Wu, Jir-You Wang, Cheng-Fong Chen, Kuang-Yu Chao, Ming-Chau Chang, Wei-Ming Chen, Shih-Chieh Hung
Cell therapies using human mesenchymal stem cells (MSCs) have received much attention in the past decade. In pursuit of the therapeutic potential of MSCs, cell expansion is required to generate a great number of cells with desired phenotype and functionality. Long-term expansion in vitro, however, can lead to altered functions. To explore the changes in DNA damage responses (DDR) in MSCs expanded, DDR pathways following irradiation were characterized in early- and late-passage bone marrow MSCs. Seventy-two hours after irradiation, the percentage of sub-G1 cells in early-passage MSCs did not change significantly...
June 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28544393/comparison-of-5-year-oncological-outcomes-of-breast-cancer-based-on-surgery-type
#2
Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Yee Soo Chae, Soo Jung Lee, Ho Yong Park
BACKGROUND: A standardized classification system for breast surgery that incorporates oncoplastic techniques is needed. We classified the surgical techniques for breast cancer treatment into five groups according to the extent of surgery and reconstructive methods, i.e. conventional breast-conserving surgery, partial mastectomy with volume displacement, partial mastectomy with volume replacement, simple mastectomy and total mastectomy with immediate reconstruction. We then evaluated the oncological outcomes for each of the five groups...
May 21, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28503704/use-of-eeg-in-critically-ill-children-and-neonates-in-the-united-states-of-america
#3
Marina Gaínza-Lein, Iván Sánchez Fernández, Tobias Loddenkemper
The objective of the study was to estimate the proportion of patients who receive an electroencephalogram (EEG) among five common indications for EEG monitoring in the intensive care unit: traumatic brain injury (TBI), extracorporeal membrane oxygenation (ECMO), cardiac arrest, cardiac surgery and hypoxic-ischemic encephalopathy (HIE). We performed a retrospective cross-sectional descriptive study utilizing the Kids' Inpatient Database (KID) for the years 2010-2012. The KID is the largest pediatric inpatient database in the USA and it is based on discharge reports created by hospitals for billing purposes...
May 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28498639/three-year-risk-of-high-grade-cin-for-women-aged-30-years-or-older-who-undergo-baseline-pap-cytology-and-hpv-co-screening
#4
Ming Guo, Abha Khanna, Jianping Wang, Marilyn A Dawlett, Teresa L Kologinczak, Genevieve R Lyons, Roland L Bassett, Nour Sneige, Yun Gong, Therese B Bevers
BACKGROUND: Papanicolaou (Pap) cytology and high-risk human papillomavirus (HPV) DNA cotesting for women aged ≥30 years are recommended for the prevention of cervical cancer. The objective of the current study was to evaluate the efficacy of this cotesting for predicting the risk of high-grade cervical intraepithelial neoplasia 3 (CIN3) during a 3-year follow-up period. METHODS: A retrospective database search identified women aged ≥30 years who had baseline HPV and Pap cytology cotesting results in 2007 or 2008 and for whom 3-year follow-up results were available...
May 12, 2017: Cancer
https://www.readbyqxmd.com/read/28464183/physician-satisfaction-in-treating-medically-unexplained-symptoms
#5
Simon G Brauer, John D Yoon, Farr A Curlin
OBJECTIVES: To determine whether treating conditions having medically unexplained symptoms is associated with lower physician satisfaction and higher ascribed patient responsibility, and to determine whether higher ascribed patient responsibility is associated with lower physician satisfaction in treating a given condition. METHODS: We surveyed a nationally representative sample of 1504 US primary care physicians. Respondents were asked how responsible patients are for two conditions with more-developed medical explanations (depression and anxiety) and two conditions with less-developed medical explanations (chronic back pain and fibromyalgia), and how much satisfaction they experienced in treating each condition...
May 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28415334/quantum-jarzynski-equality-of-measurement-based-work-extraction
#6
Yohei Morikuni, Hiroyasu Tajima, Naomichi Hatano
Many studies of quantum-size heat engines assume that the dynamics of an internal system is unitary and that the extracted work is equal to the energy loss of the internal system. Both assumptions, however, should be under scrutiny. In the present paper, we analyze quantum-scale heat engines, employing the measurement-based formulation of the work extraction recently introduced by Hayashi and Tajima [M. Hayashi and H. Tajima, arXiv:1504.06150]. We first demonstrate the inappropriateness of the unitary time evolution of the internal system (namely, the first assumption above) using a simple two-level system; we show that the variance of the energy transferred to an external system diverges when the dynamics of the internal system is approximated to a unitary time evolution...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28410503/continuous-micro-current-stimulation-to-upgrade-methanolic-wastewater-biodegradation-and-biomethane-recovery-in-an-upflow-anaerobic-sludge-blanket-uasb-reactor
#7
Guangyin Zhen, Xueqin Lu, Takuro Kobayashi, Lianghu Su, Gopalakrishnan Kumar, Péter Bakonyi, Yan He, Periyasamy Sivagurunathan, Nándor Nemestóthy, Kaiqin Xu, Youcai Zhao
The dispersion of granules in upflow anaerobic sludge blanket (UASB) reactor represents a critical technical issue in methanolic wastewater treatment. In this study, the potentials of coupling a microbial electrolysis cell (MEC) into an UASB reactor for improving methanolic wastewater biodegradation, long-term process stability and biomethane recovery were evaluated. The results indicated that coupling a MEC system was capable of improving the overall performance of UASB reactor for methanolic wastewater treatment...
April 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28400086/corrigendum-to-epicutaneous-immunization-with-protein-antigen-tnp-ig-alleviates-tnbs-induced-colitis-in-mice-pharmacol-rep-64-2012-1497-1504
#8
Monika Majewska-Szczepanik, Marta Góralska, Katarzyna Marcińska, Magdalena Zemelka-Wiącek, Anna Strzępa, Iwona Dorożyńska, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28386272/laparoscopic-hepatectomy-current-state-in-japan-based-on-the-4th-nationwide-questionnaire
#9
Yutaka Takahashi, Satoshi Katagiri, Shun-Ichi Ariizumi, Yoshihito Kotera, Hiroto Egawa, Go Wakabayashi, Hironori Kaneko, Masakazu Yamamoto
Purpose. Since laparoscopic hepatectomy (LH) became covered by national health insurance in April 2010 in Japan, the numbers of applied cases and institutions performing it have increased and the indication has expanded. We surveyed the current state and safety of LH in Japan. Methods. A questionnaire survey was performed in 41 institutions related to the Japanese Endoscopic Liver Surgery Study Group and 747 institutions certified by the Japanese Society of Gastroenterological Surgery, and responses concerning all 2962 cases of LH performed by August 2011 were obtained...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28367840/the-effect-of-irrigation-solutions-on-recurrence-of-chronic-subdural-hematoma-a-consecutive-cohort-study-of-234-patients
#10
Masashi Kuwabara, Takashi Sadatomo, Kiyoshi Yuki, Keisuke Migita, Yasutaka Imada, Kiyoharu Shimizu, Takeshi Hara, Hideo Oba, Kaoru Kurisu
Chronic subdural hematomas (CSDHs) occur often in elderly persons and can occur with mild head trauma. With burr-hole irrigation as standard treatment, symptoms usually improve and can be cured, and outcomes are good, but postoperative recurrences are a common problem. This study investigated the effectiveness and recurrence rates when using artificial cerebrospinal fluid (ACF) instead of normal saline (NS) as an irrigation solution for burr-hole irrigation in patients with CSDH. This prospective study included 234 consecutive patients who underwent initial surgical treatment by burr-hole irrigation for a CSDH between April 2008 and June 2015...
March 30, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28281406/the-contributions-of-family-care-givers-at-end-of-life-a-national-post-bereavement-census-survey-of-cancer-carers-hours-of-care-and-expenditures
#11
Christine Rowland, Barbara Hanratty, Mark Pilling, Bernard van den Berg, Gunn Grande
BACKGROUND: Family members provide vital care at end of life, enabling patients to remain at home. Such informal care contributes significantly to the economy while supporting patients' preferences and government policy. However, the value of care-givers' contributions is often underestimated or overlooked in evaluations. Without information on the activities and expenditures involved in informal care-giving, it is impossible to provide an accurate assessment of carers' contribution to end-of-life care...
April 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28259358/prognostic-significance-of-lymphatic-vascular-and-perineural-invasion-for-bladder-cancer-patients-treated-by-radical-cystectomy
#12
Prasuna Muppa, Sounak Gupta, Igor Frank, Stephen A Boorjian, R Jeffrey Karnes, R Houston Thompson, Prabin Thapa, Robert F Tarrell, Loren P Herrera Hernandez, Rafael E Jimenez, John C Cheville
In radical cystectomy specimens with bladder cancer, lymphatic and vascular invasion are often reported as 'angiolymphatic' or 'lymphovascular' invasion, terms that combine the findings of tumour within simple endothelial-lined lymphatic spaces and tumour within muscle-lined blood vessels. It is unclear if these patterns of invasion have different prognostic significance. In addition, there are conflicting data regarding the significance of lymphatic, vascular and perineural invasion in patients with bladder cancer...
April 2017: Pathology
https://www.readbyqxmd.com/read/28179271/childhood-cancer-type-1-diabetes-and-other-immune-diseases-healthcare-visits-in-the-year-before-diagnosis-in-taiwan
#13
TienYu Owen Yang, Wan-Ting Huang, Mei-Huei Chen, Kuan-Ying Arthur Huang, Pau-Chung Chen
BACKGROUND: Children with cancer, type 1 diabetes and other immune diseases often present initially with non-specific problems. It is unknown how long children with these conditions seek medical help before a diagnosis is reached. METHODS: During the period 2002 to 2013, 7238 children aged 2-15 years diagnosed with cancer at seven sites, type 1 diabetes, and three other immune diseases were registered in the Taiwan National Health Insurance Catastrophic Illness Database...
February 8, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28121975/international-epidemiological-differences-in-acute-poisonings-in-pediatric-emergency-departments
#14
Santiago Mintegi, Beatriz Azkunaga, Javier Prego, Nadeem Qureshi, Stuart R Dalziel, Eunate Arana-Arri, Yordana Acedo, Lorea Martinez-Indart, Arantza Urkaregi, Nerea Salmon, Javier Benito, Nathan Kuppermann
BACKGROUND AND OBJECTIVE: Identifying international differences in the epidemiology of acute poisonings in children may help in improving prevention. We sought to evaluate the international epidemiological differences in acute poisonings in children presenting to emergency departments (EDs) from 8 different global regions. METHODS: This was an international multicenter cross-sectional prospective study including children younger than 18 years with acute poisonings presenting to 105 EDs in 20 countries was conducted...
January 24, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28105621/-analysis-of-risk-factors-for-bone-metastasis-after-radical-resection-of-colorectal-cancer-within-5-years
#15
Ang Li, Zhen Tan, Chuangang Fu, Hao Wang, Jie Yuan
OBJECTIVE: To investigate the risk factors of metachronous bone metastasis after radical resection of colorectal cancer within 5 years. METHODS: Clinical data of 1 749 patients with colorectal cancer, of whom 50(2.8%) patients developed metastasis to bone after operation, in the Department of Colorectal Surgery, Changhai Hospital of The Second Military Medical University from January 2001 to December 2010 were analyzed retrospectively. Univariate and multivariate analysis were performed to find the risk factors of metachronous bone metastasis from colorectal cancer using Chi square test and Logistic regression, respectively...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28095574/managing-occupational-irritant-contact-dermatitis-using-a-two-step-skincare-regimen-designed-to-prevent-skin-damage-and-support-skin-recovery
#16
REVIEW
Erika C von Grote, Kiruthi Palaniswarmy, Matthew H Meckfessel
Occupational irritant contact dermatitis (ICD) affecting the hands is a common and difficult-to-manage condition. Occupations that necessitate contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing elevate the risk of ICD. Management strategies that do not adequately prevent accumulated damage and repair skin, can develop into chronic dermatoses which negatively impact work productivity and quality of life. A 2-step skin-care regimen (Excipial Daily Protection Hand Cream (EP) and Excipial Rapid Repair Hand Cream (ER), Galderma Laboratories, L...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28092274/power-profiles-and-in-vitro-optical-quality-of-scleral-contact-lenses-effect-of-the-aperture-and-power
#17
Alberto Domínguez-Vicent, Jose Juan Esteve-Taboada, Alberto Recchioni
OBJECTIVE: To assess the power profile and in vitro optical quality of scleral contact lenses with different powers as a function of the optical aperture. METHODS: The mini and semiscleral contact lenses (Procornea) were measured for five powers per design. The NIMO TR-1504 (Lambda-X) was used to assess the power profile and Zernike coefficients of each contact lens. Ten measurements per lens were taken at 3- and 6-mm apertures. Furthermore, the optical quality of each lens was described in Zernike coefficients, modulation transfer function, and point spread function (PSF)...
January 13, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28077150/the-equity-of-china-s-emergency-medical-services-from-2010-2014
#18
Ke Yan, Yi Jiang, Jingfu Qiu, Xiaoni Zhong, Yang Wang, Jing Deng, Jingxi Lian, Tingting Wang, Cheng Cao
BACKGROUND: With the depth development of health care system reform in China, emergency medical services (EMS) is confronted with challenges as well as opportunities. This study aimed to analyze the equity of China's EMS needs, utilization, and resources distribution, and put forward proposal to improve the equity. METHOD: Three emergency needs indicators (mortality rate of cardiovascular and cerebrovascular diseases, harm, and digestive system disease), two utilization indicators (emergency outpatient visits and rate of utilization) and one resource allocation indicator (number of EMS facilities) were collected after the review of the China Statistical Yearbook and the National Disease Surveillance System...
January 11, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28072434/remiss-med-bild-%C3%A2-j%C3%A3-mlik-och-kostnadseffektiv-v%C3%A3-rd-kortare-tid-till-diagnos-och-f%C3%A3-rre-l%C3%A3-nga-patientresor
#19
Nirina Andersson, Anna Preisler-Häggqvist, Virginia Zazo Hernanz
This study evaluates the use of teledermatology at Norrland University Hospital in Northern Sweden between 2009 and 2014. In total, there were 27 198 incoming referrals. Of these, 1504 had photo attachments, and could be answered directly without a face-to-face appointment. Most of these referrals (73%) came from health care providers more than 100 kilometres away and 71% were answered within a week. Patients received care sooner and saved both time and money by less travelling. Teledermatology lead to less delay to a face-to-face appointment for patients where teledermatology was not an option...
January 9, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28065877/charles-estienne-1504-1564-his-life-work-and-contribution-to-anatomy-and-the-first-description-of-the-canal-in-the-spinal-cord
#20
REVIEW
Konstantinos Markatos, Demetrios Chytas, Demetrios Korres, Konstantinos Laios, Georgios Androutsos, Efstathios Chronopoulos
The purpose of this historic review is to summarize the life, work, and contribution to anatomy of Charles Estienne (also known by the Latin name Carolus Stephanus). Charles Estienne was an early exponent of the science of anatomy in France. Although he remained under the influence of the Galenic tradition of medicine, anatomy, and surgery throughout his distinguished career, he had a significant influence on the scientific revolution and anatomy reformation of the 16th century. Nevertheless, he cannot be placed at the same level of contribution as Vesalius, because of his lack of discipline in his work, hesitation to diverge totally from traditional beliefs, and his hesitation for a total criticism of the Galenic tradition...
April 2017: World Neurosurgery
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