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Mirna 143

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https://www.readbyqxmd.com/read/28644441/micrornas-143-and-145-induce-epithelial-to-mesenchymal-transition-and-modulate-the-expression-of-junction-proteins
#1
Lidia Avalle, Danny Incarnato, Aurora Savino, Marta Gai, Francesca Marino, Sara Pensa, Isaia Barbieri, Michael B Stadler, Paolo Provero, Salvatore Oliviero, Valeria Poli
Transforming growth factor (TGF)-β is one of the major inducers of epithelial to mesenchymal transition (EMT), a crucial program that has a critical role in promoting carcinoma's metastasis formation. MicroRNAs-143 and -145, which are both TGF-β direct transcriptional targets, are essential for the differentiation of vascular smooth muscle cells (VSMC) during embryogenesis, a TGF-β-dependent process reminiscent of EMT. Their role in adult tissues is however less well defined and even ambiguous, as their expression was correlated both positively and negatively with tumor progression...
June 23, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28644440/lncrna-sarcc-suppresses-renal-cell-carcinoma-rcc-progression-via-altering-the-androgen-receptor-ar-mirna-143-3p-signals
#2
Wei Zhai, Yin Sun, Changcheng Guo, Guanghui Hu, Mingchao Wang, Jiayi Zheng, WanYing Lin, Qingbo Huang, Gonghui Li, Junhua Zheng, Chawnshang Chang
While the androgen receptor (AR) might promote renal cell carcinoma (RCC) initiation and progression, the molecular mechanisms involved remain largely unclear. Here, we discovered the novel LncRNA-SARCC, which was suppressed and associated with better prognosis in RCC. Preclinical studies using multiple RCC cells and in vivo mouse model indicated that LncRNA-SARCC could attenuate RCC cell invasion, migration and proliferation in vitro and in vivo. Mechanistically, LncRNA-SARCC bound and destabilized AR protein with an inhibition of AR function, which led to transcriptionally de-repress miR-143-3p expression, thus inhibition of its downstream signals including AKT, MMP-13, K-RAS and P-ERK...
June 23, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28643818/serum-micrornas-are-altered-in-various-stages-of-chronic-kidney-disease-a-preliminary-study
#3
COMMENT
Benjamin Brigant, Valérie Metzinger-Le Meuth, Ziad A Massy, Nathalie McKay, Sophie Liabeuf, Marion Pelletier, Marion Sallée, Eléonore M'Baya-Moutoula, Pascale Paul, Tilman B Drueke, Stéphane Burtey, Laurent Metzinger
BACKGROUND: MicroRNAs (miRNAs) are innovative and informative blood-based biomarkers involved in numerous pathophysiological processes. In this study and based on our previous experimental data, we investigated miR-126, miR-143, miR-145, miR-155 and miR-223 as potential circulating biomarkers for the diagnosis and prognosis of patients with chronic kidney disease (CKD). The primary objective of this study was to assess the levels of miRNA expression at various stages of CKD. METHODS: RNA was extracted from serum, and RT-qPCR was performed for the five miRNAs and cel-miR-39 (internal control)...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28633641/expression-levels-of-atherosclerosis-associated-mir-143-and-mir-145-in-the-plasma-of-patients-with-hyperhomocysteinaemia
#4
Kejian Liu, Saiyare Xuekelati, Yue Zhang, Yin Yin, Yue Li, Rui Chai, Xinwei Li, Yi Peng, Jiangdong Wu, Xiaomei Guo
BACKGROUND: An elevated level of homocysteine (Hcy) in the blood is designated hyperhomocysteinaemia (Hhcy) and is regarded as a strong risk factor for the development of atherosclerosis (ATH), although the association remains controversial. Considered to be essential gene expression regulators, micro-RNAs (miRNAs) modulate cardiovascular disease development and thus can be regarded as potential biomarkers and therapeutic targets in atherosclerosis. The aim of the current study is to investigate the expression levels of atherosclerosis-associated miR-143 and miR-145 in Hhcy patients and predict the progress of atherosclerosis in Hhcy patients...
June 20, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28628624/heterogeneity-of-mirna-expression-in-localized-prostate-cancer-with-clinicopathological-correlations
#5
Ahmed Hussein Zedan, Søren Garm Blavnsfeldt, Torben Frøstrup Hansen, Boye Schnack Nielsen, Niels Marcussen, Mindaugas Pleckaitis, Palle Jörn Sloth Osther, Flemming Brandt Sørensen
INTRODUCTION: In the last decade microRNAs (miRNAs) have been widely investigated in prostate cancer (PCa) and have shown to be promising biomarkers in diagnostic, prognostic and predictive settings. However, tumor heterogeneity may influence miRNA expression. The aims of this study were to assess the impact of tumor heterogeneity, as demonstrated by a panel of selected miRNAs in PCa, and to correlate miRNA expression with risk profile and patient outcome. MATERIAL AND METHODS: Prostatectomy specimens and matched, preoperative needle biopsies from a retrospective cohort of 49 patients, who underwent curatively intended surgery for localized PCa, were investigated with a panel of 6 miRNAs (miRNA-21, miRNA-34a, miRNA-125b, miRNA-126, miRNA-143, and miRNA-145) using tissue micro-array (TMA) and in situ hybridization (ISH)...
2017: PloS One
https://www.readbyqxmd.com/read/28605652/screening-and-confirmation-of-microrna-markers-for-distinguishing-between-menstrual-and-peripheral-blood
#6
Zhilong Li, Peng Bai, Duo Peng, Hui Wang, Yadong Guo, Youjing Jiang, Wang He, Huan Tian, Yu Yang, Yuan Huang, Bing Long, Weibo Liang, Lin Zhang
The identification of menstrual blood (MB) and peripheral blood (PB) left at a crime scene is crucial for crime reconstruction, especially in sexual assaults. MicroRNAs (miRNAs), a class of non-protein coding molecules, have been demonstrated to be a viable tool for body fluid identification in forensic casework. Several groups have searched for miRNAs that are specific to different body fluids. Blood has been studied the most extensively. However, menstrual blood was only involved in five studies, and the results confirming the presence of specific miRNAs could not be reproduced in other studies...
June 3, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28600979/circulating-microvesicle-number-function-and-small-rna-content-vary-with-age-gender-smoking-status-lipid-and-hormone-profiles
#7
Anoop K Enjeti, Anita Ariyarajah, Angel D'Crus, Michael Seldon, Lisa F Lincz
BACKGROUND: Characterization of circulating microvesicles (MV) in healthy subjects in relation to various biological factors is not well studied. OBJECTIVES: We evaluated the influence of age, gender, smoking status, lipid and hormone profiles on circulating MV in healthy subjects. METHODS: Platelet free plasma from 143 volunteer blood donors (males=80, females=63) was evaluated by standardized flow cytometry for MV expressing CD41 (platelet-derived), CD105 (endothelial-derived), CD235 (red cell-derived), TF (tissue factor) and phosphatidylserine (PS) MV...
April 20, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28596604/mir-143-and-mir-145-disrupt-the-cervical-epithelial-barrier-through-dysregulation-of-cell-adhesion-apoptosis-and-proliferation
#8
Lauren Anton, Ann DeVine, Luz-Jeannette Sierra, Amy G Brown, Michal A Elovitz
Molecular mechanisms regulating preterm birth (PTB)-associated cervical remodeling remain unclear. Prior work demonstrated an altered miRNA profile, with significant increases in miR-143 and miR-145, in cervical cells of women destined to have a PTB. The study objective was to determine the effect of miR-143 and miR-145 on the cervical epithelial barrier and to elucidate the mechanisms by which these miRNAs modify cervical epithelial cell function. Ectocervical and endocervical cells transfected with miR-negative control, miR-143 or miR-145 were used in cell permeability and flow cytometry assays for apoptosis and proliferation...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28586912/comparison-of-microrna-expression-in-aqueous-humor-of-normal-and-primary-open-angle-glaucoma-patients-using-pcr-arrays-a-pilot-study
#9
Hari Jayaram, Jay I Phillips, Diana C Lozano, Tiffany E Choe, William O Cepurna, Elaine C Johnson, John C Morrison, Devin M Gattey, Julie A Saugstad, Kate E Keller
Purpose: MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that have been detected in human aqueous humor (AH). Prior studies have pooled samples to obtain sufficient quantities for analysis or used next-generation sequencing. Here, we used PCR arrays with preamplification to identify and compare miRNAs from individual AH samples between patients with primary open-angle glaucoma (POAG) and normal controls. Methods: AH was collected before cataract surgery from six stable, medically treated POAG patients and eight age-matched controls...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28580875/matrix-bound-nanovesicles-recapitulate-extracellular-matrix-effects-on-macrophage-phenotype
#10
Luai Huleihel, Joseph Bartolacci, Jenna Lynn Dziki, Tatiana Vorobyov, Brooke Arnold, Michelle Scarritt, Catalina Pineda Molina, Samuel LoPresti, Bryan Brown, Stephen F Badylak
The early macrophage response to biomaterials has been shown to be a critical and predictive determinant of downstream outcomes. When properly prepared, bioscaffolds derived from mammalian extracellular matrix (ECM) have been shown to promote a transition in macrophage behavior from a pro-inflammatory to a regulatory/anti-inflammatory phenotype, which in turn has been associated with constructive and functional tissue repair. The mechanism by which ECM bioscaffolds promote this phenotypic transition, however, is poorly understood...
June 4, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28570996/identification-of-circulating-microrna-signatures-as-potential-noninvasive-biomarkers-for-prediction-and-prognosis-of-lymph-node-metastasis-in-gastric-cancer
#11
Xiumei Jiang, Wenfei Wang, Yongmei Yang, Lutao Du, Xiaoyun Yang, Lili Wang, Guixi Zheng, Weili Duan, Rui Wang, Xin Zhang, Lishui Wang, Xiaoyang Chen, Chuanxin Wang
Circulating microRNAs (miRNAs) are emerging as novel noninvasive biomarkers for prediction of lymph node metastasis (LNM) in cancer. The aim of this study was to identify serum miRNA signatures for prediction and prognosis of LNM in gastric cancer (GC). MiSeq sequencing was performed for an initial screening of serum miRNAs in 10 GC patients with LNM, 10 patients without LNM and 10 healthy controls. Reverse transcription quantitative real-time PCR was applied to confirm concentration of candidate miRNAs using a training cohort (n = 279) and a validation cohort (n = 180)...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28522551/inhibition-of-mir-143-during-ischemia-cerebral-injury-protects-neurons-through-recovery-of-the-hexokinase-2-mediated-glucose%C3%A2-uptake
#12
Xianzhu Zeng, Na Liu, Jing Zhang, Lei Wang, Zhecheng Zhang, Ju Zhu, Qian Li, Yuwen Wang
Ischemic stroke, a major cause of death, is caused by occlusion of a blood vessel, resulting in a significant reduction in regional cerebral blood flow. MicroRNAs (miRNAs) are a family of short noncoding RNAs (18 to 22 nucleotides) and bind the 3' un-translated region (UTR) of their target genes to post-transcriptionally suppress gene expression. In this study, we report miR-143 is downregulated in rat neurons but high expressed in astrocytes cells. In vivo middle cerebral artery occlusion (MCAO) and ex vivo oxygen-glucose deprivation (OGD) results showed miR-143 was significantly induced by ischemia injury...
May 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28511343/restoration-of-mir-143-expression-could-inhibit-migration-and-growth-of-mda-mb-468-cells-through-down-regulating-the-expression-of-invasion-related-factors
#13
Fatemeh Tavanafar, Reza Safaralizadeh, Mohammad Ali Hosseinpour-Feizi, Behzad Mansoori, Dariush Shanehbandi, Ali Mohammadi, Behzad Baradaran
INTRODUCTION: Breast adenocarcinoma is the second common cancer in women the incidence of which is increasing in many countries, especially in developing companies. In this study, miRNA143 has been replaced by vector based microRNA-143 in breast adenocarcinoma cells (MDA-MB-468) and its anti-cancer effects on breast adenocarcinoma cells have been evaluated. METHODS: The pCMV-MIR-143 vector was transfected into MDA-MB-468 cells via JetPEI transfection reagent. The transfected cells were selected by IC50 concentration of Geneticin antibiotic (G418) after a 2-week treatment...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28507337/identification-and-comparative-analysis-of-the-ovarian-micrornas-of-prolific-and-non-prolific-goats-during-the-follicular-phase-using-high-throughput-sequencing
#14
Xiang-Dong Zi, Jian-Yuan Lu, Li Ma
The kidding rate is one of the most important economic traits for goat production, but the genetic mechanism that is associated with ovulation rate is poorly understood. Recently, increasing evidence has suggested that microRNAs (miRNAs) influence ovarian biological processes. The present study provides the first comparison of the ovarian miRNAs of prolific Jintang black goats (JTGs) and non-prolific Tibetan goats (TBGs) during the follicular phase using RNA-Seq technology. We generated 11.19 million (M) and 11...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495174/ppar%C3%AE-mediated-g-protein-coupled-receptor-120-signaling-pathway-promotes-transcriptional-activation-of-mir-143-in-adipocytes
#15
In-Seon Bae, Phil June Park, Jeong Hwa Lee, Eun-Gyung Cho, Tae Ryong Lee, Sang Hoon Kim
MicroRNAs (miRNAs), the small noncoding RNAs, regulate various biological processes such as adipogenesis. MicroRNA-143 (miR-143) promotes adipocyte differentiation, and is correlated with obesity in mice fed a high-fat diet. However, the transcriptional regulation of miR-143 is largely unknown. In this study, we identified that miR-143 is a target of peroxisome proliferator-activated receptor γ (PPARγ), a key transcription factor in adipogenesis. Four putative peroxisome proliferator response elements (PPREs) were identified in the miR-143 promoter region...
May 8, 2017: Gene
https://www.readbyqxmd.com/read/28492554/the-novel-long-intergenic-noncoding-rna-ucc-promotes-colorectal-cancer-progression-by-sponging-mir-143
#16
Feng-Ting Huang, Wen-Ying Chen, Zhi-Qiang Gu, Yan-Yan Zhuang, Chu-Qiang Li, Ling-Yun Wang, Juan-Fei Peng, Zhe Zhu, Xin Luo, Yuan-Hua Li, He-Rui Yao, Shi-Neng Zhang
The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. A novel lincRNA termed upregulated in CRC (UCC) was found to be highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node metastasis, Dukes' stage, and patient outcomes. In SW480 and SW620 cells, knockdown of UCC inhibited proliferation, invasion, and cell cycle progression and induced apoptosis in vitro...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28474233/association-analysis-of-rs1049255-and-rs4673-transitions-in-p22phox-gene-with-coronary-artery-disease-a-case-control-study-and-a-computational-analysis
#17
M Mazaheri, M Karimian, M Behjati, F Raygan, A Hosseinzadeh Colagar
BACKGROUND: The p22phox gene encodes the main subunit of NADH/NADPH-oxidase. This enzyme is expressed in smooth muscle cells of arteries, and it produces the reactive oxygen species. On the other hand, oxidative stress plays a main role in the pathogenesis of coronary artery disease (CAD). AIM: The aim of this study is to evaluate the association between rs4673 and rs1049255 polymorphisms of p22phox gene with CAD in an Iranian population which was followed with a computational analysis approach...
May 4, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28464030/screening-candidate-micrornas-mirnas-in-different-lambskin-hair-follicles-in-hu-sheep
#18
Wen Gao, Wei Sun, Jinfeng Yin, Xiaoyang Lv, Jianjun Bao, Jiarui Yu, Lihong Wang, Chengyan Jin, Liang Hu
Hu sheep lambskin is a unique white lambskin from China that exhibits three types of flower patterns, including small waves, medium waves, and large waves, with small waves considered the best quality. However, our understanding of the molecular mechanism underlying flower pattern formation in Hu sheep lambskin is limited. The aim of the present study was to further explore the relevance between candidate microRNAs (miRNAs) and developmental characteristics of hair follicles and screen miRNAs for later functional validation...
2017: PloS One
https://www.readbyqxmd.com/read/28456786/apoptosis-related-microrna-145-5p-enhances-the-effects-of-pheophorbide-a-based-photodynamic-therapy-in-oral-cancer
#19
Sook Moon, Do Kyeong Kim, Jin Kim
MicroRNAs (miRNAs) regulate key biological processes, and their aberrant expression has been related to cancer development. Photodynamic therapy (PDT) has emerged as one of the most promising modalities for cancer treatment. However, the application of PDT has been limited to superficially localized human cancerous and precancerous lesions. To increase the usefulness of both PDT and miRNAs in cancer therapy, this study investigated whether apoptosis-related miRNA expression is influenced by PDT in oral cancer and whether miRNAs can enhance PDT efficacy...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454844/serum-mirnas-mir-206-143-3p-and-374b-5p-as-potential-biomarkers-for-amyotrophic-lateral-sclerosis-als
#20
Rachel Waller, Emily F Goodall, Marta Milo, Jonathan Cooper-Knock, Marc Da Costa, Esther Hobson, Mbombe Kazoka, Helen Wollff, Paul R Heath, Pamela J Shaw, Janine Kirby
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative condition characterized by loss of motor neurones and progressive muscle wasting. There is no diagnostic test for ALS therefore robust biomarkers would not only be valuable for diagnosis, but also for the classification of disease subtypes, monitoring responses to drugs and tracking disease progression. As regulators of gene expression, microRNAs (miRNAs) are increasingly used for diagnostic and prognostic purposes in various disease states with increasing exploration in neurodegenerative disorders...
July 2017: Neurobiology of Aging
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