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Mirna 143

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https://www.readbyqxmd.com/read/29137392/selective-secretion-of-micrornas-from-lung-cancer-cells-via-extracellular-vesicles-promotes-camk1d-mediated-tube-formation-in-endothelial-cells
#1
James Lawson, Christopher Dickman, Sara MacLellan, Rebecca Towle, James Jabalee, Stephen Lam, Cathie Garnis
Extracellular vesicles (EVs) are key signaling mediators between cancer cells and their supporting stroma, and regulate critical processes such as invasion, metastases, and angiogenesis. We have identified a subset of miRNAs (miR-142-3p, miR-143-3p, miR-145-5p, miR-150-5p, miR-223-3p, miR-451a, miR-486-5p, miR-605-5p) that are enriched in lung adenocarcinoma extracellular vesicles compared to the donor cells from which they were derived. Two well-known tumor suppressors, miR-143-3p and miR-145-5p, were also enriched in serum samples collected during surgery from blood vessels draining directly from lung adenocarcinoma tumor beds...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137387/infrequently-expressed-mirnas-influence-survival-after-diagnosis-with-colorectal-cancer
#2
Martha L Slattery, Andrew J Pellatt, Frances Y Lee, Jennifer S Herrick, Wade S Samowitz, John R Stevens, Roger K Wolff, Lila E Mullany
Half of miRNAs expressed in colorectal tissue are expressed < 50% of the population. Many infrequently expressed miRNAs have low levels of expression. We hypothesize that less frequently expressed miRNAs, when expressed at higher levels, influence both disease stage and survival after diagnosis with colorectal cancer (CRC); low levels of expression may be background noise. We examine 304 infrequently expressed miRNAs in 1893 population-based cases of CRC with paired carcinoma and normal mucosa miRNA profiles...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29118269/genetic-architecture-and-regulatory-impact-on-hepatic-microrna-expression-linked-to-immune-and-metabolic-traits
#3
Siriluck Ponsuksili, Nares Trakooljul, Frieder Hadlich, Fiete Haack, Eduard Murani, Klaus Wimmers
Regulation of microRNA (miRNA) expression contributes to a wide range of target gene expression and phenotypes. The miRNA expression in the liver, the central metabolic organ, was examined in 209 pigs, and integrated with haematological and clinical biomarkers of metabolic and overall health, mRNA-target expression levels and single-nucleotide polymorphism (SNP) genotypes. The expression levels of 426 miRNA species correlated with plasma haematological or biochemical traits (r² = |0.19-0.45|, false discovery rate < 5%)...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29108299/serum-mir-143-levels-predict-the-pathological-response-to-neoadjuvant-chemoradiotherapy-in-patients-with-locally-advanced-rectal-cancer
#4
Yukiharu Hiyoshi, Takashi Akiyoshi, Ramu Inoue, Keiko Murofushi, Noriko Yamamoto, Yosuke Fukunaga, Masashi Ueno, Hideo Baba, Seiichi Mori, Toshiharu Yamaguchi
Recently, several circulating miRNAs have been reported as promising, minimally invasive biomarkers for the diagnosis or prediction of the prognosis in various types of cancer. However, the utility of circulating miRNAs as predictive markers of the cancer response to neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer is still unclear. To identify circulating serum miRNAs useful for predicting a pathological good response to nCRT, total 18 serum miRNAs of interest were analyzed by real-time polymerase chain reaction in 94 rectal cancer patients treated with nCRT and surgery...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102598/dicer1-gene-and-mirna-dysregulation-in-mesenchymal-stem-cells-of-patients-with-myelodysplastic-syndrome-and-acute-myeloblastic-leukemia
#5
Hakan Ozdogan, Bala Gur Dedeoglu, Yasemin Oztemur Islakoglu, Alp Aydos, Sevil Kose, Arzu Atalay, Zeynep Arzu Yegin, Ferit Avcu, Duygu Ocean Cetinkaya, Osman Ilhan
Multipotent mesenchymal stem cells (MSC) are key components of the bone marrow (BM) microenvironment. The contribution of this microenvironment to the pathophysiology of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is not well defined. A recent study in mice demonstrated that DICER1 gene deletion in osteoprogenitor cells from the BM microenvironment suppressed osteogenic differentiation and induced MDS and AML-like haematological findings. The present study evaluated the expression profiles of microRNAs (miRNAs) and DICER1 gene in BM-derived MSC of patients with AML (n=12), MDS (n=10) and healthy controls (HC) (n=8)...
October 31, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29073938/musashi-2-a-novel-oncoprotein-promoting-cervical-cancer-cell-growth-and-invasion-is-negatively-regulated-by-p53-induced-mir-143-and-mir-107-activation
#6
Peixin Dong, Ying Xiong, Sharon J B Hanley, Junming Yue, Hidemichi Watari
BACKGROUND: Although previous studies have shown promise for targeting Musashi RNA-binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 for cervical cancer (CC) progression and the regulation of MSI-2 expression remains unclear. METHODS: Using gene expression and bioinformatic analysis, together with gain- and loss-of-function assays, we identified MSI-2 as a novel oncogenic driver and a poor prognostic marker in CC. We explored the regulation of c-FOS by MSI-2 via RNA-immunoprecipitation and luciferase assay, and confirmed a direct inhibition of MSI-2 by miR-143/miR-107 using luciferase assay...
October 26, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29073169/expression-and-function-of-the-mir-143-145-cluster-in-vitro-and-in-vivo-in-human-breast-cancer
#7
Charles Johannessen, Line Moi, Yury Kiselev, Mona Irene Pedersen, Stig Manfred Dalen, Tonje Braaten, Lill-Tove Busund
MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional regulators of gene expression and are dysregulated in cancer. Studies of miRNAs to explore their potential as diagnostic and prognostic markers are of great scientific interest. Here, we investigate the functional properties and expression of the miR-143/145 cluster in breast cancer (BC) in vitro and in vivo. The ER positive MCF7, the HER2 positive SK-BR-3, and the triple negative cell line MDA-MB-231 were used to assess cell proliferation and cell invasion...
2017: PloS One
https://www.readbyqxmd.com/read/29036355/design-and-implementation-of-a-synthetic-pre-mir-switch-for-controlling-mirna-biogenesis-in-mammals
#8
Janina Atanasov, Florian Groher, Julia E Weigand, Beatrix Suess
Synthetic RNA-based systems have increasingly been used for the regulation of eukaryotic gene expression. Due to their structural properties, riboregulators provide a convenient basis for the development of ligand-dependent controllable systems. Here, we demonstrate reversible conditional control of miRNA biogenesis with an aptamer domain as a sensing unit connected to a natural miRNA precursor for the first time. For the design of the pre-miR switch, we replaced the natural terminal loop with the TetR aptamer...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29029418/identification-of-circulating-microrna-signatures-as-potential-noninvasive-biomarkers-for-prediction-and-prognosis-of-lymph-node-metastasis-in-gastric-cancer
#9
Xiumei Jiang, Wenfei Wang, Yongmei Yang, Lutao Du, Xiaoyun Yang, Lili Wang, Guixi Zheng, Weili Duan, Rui Wang, Xin Zhang, Lishui Wang, Xiaoyang Chen, Chuanxin Wang
Circulating microRNAs (miRNAs) are emerging as novel noninvasive biomarkers for prediction of lymph node metastasis (LNM) in cancer. The aim of this study was to identify serum miRNA signatures for prediction and prognosis of LNM in gastric cancer (GC). MiSeq sequencing was performed for an initial screening of serum miRNAs in 10 GC patients with LNM, 10 patients without LNM and 10 healthy controls. Reverse transcription quantitative real-time PCR was applied to confirm concentration of candidate miRNAs using a training cohort (n = 279) and a validation cohort (n = 180)...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29022908/mir-143-and-mir-145-inhibit-gastric-cancer-cell-migration-and-metastasis-by-suppressing-myo6
#10
Chao Lei, Feng Du, Lina Sun, Ting Li, Tingyu Li, Yali Min, Aiying Nie, Xin Wang, Lei Geng, Yuanyuan Lu, Xiaodi Zhao, Yongquan Shi, Daiming Fan
Metastasis is a major clinical obstacle responsible for the high mortality and poor prognosis of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators of metastasis that act by modulating their target genes. In this study, we found that miR-143 and miR-145 act via a common target gene, MYO6, to regulate the epithelial-mesenchymal transition (EMT) and inhibit metastasis. We determined that miR-143 and miR-145 were downregulated in GC, and the ectopic expression of miR-143 and/or miR-145 inhibited GC cell migration and metastasis...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28977982/pooling-analysis-for-diagnostic-and-prognostic-value-of-mirna-100-in-various-cancers
#11
REVIEW
Zhe Dou, Shuai Lin, Cong Dai, Ye Lu, Tian Tian, Meng Wang, Xinghan Liu, Yi Zheng, Peng Xu, Shanli Li, Qianwen Sheng, Yujiao Deng, Zhijun Dai
Many studies manifested miRNA-100 was deregulated in various cancers, which indicated that miRNA-100 might be a potential biomarker of cancer diagnosis and prognosis. However, the role of miRNA-100 was still uncertain. We searched for qualified studies using PubMed, EMBASE, Web of Science, Cochrane library and CNKI databases. The diagnostic effect was evaluated by the pooled sensitivity, specificity, and other indexes. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) were calculated to assess the prognostic value...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28951568/using-computer-simulation-models-to-investigate-the-most-promising-micrornas-to-improve-muscle-regeneration-during-ageing
#12
Carole J Proctor, Katarzyna Goljanek-Whysall
MicroRNAs (miRNAs) regulate gene expression through interactions with target sites within mRNAs, leading to enhanced degradation of the mRNA or inhibition of translation. Skeletal muscle expresses many different miRNAs with important roles in adulthood myogenesis (regeneration) and myofibre hypertrophy and atrophy, processes associated with muscle ageing. However, the large number of miRNAs and their targets mean that a complex network of pathways exists, making it difficult to predict the effect of selected miRNAs on age-related muscle wasting...
September 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931951/screening-of-mirna-profiles-and-construction-of-regulation-networks-in-early-and-late-lactation-of-dairy-goat-mammary-glands
#13
Zhibin Ji, Zhaohua Liu, Tianle Chao, Lei Hou, Rui Fan, Rongyan He, Guizhi Wang, Jianmin Wang
In recent years, studies related to the expression profiles of miRNAs in the dairy goat mammary gland were performed, but regulatory mechanisms in the physiological environment and the dynamic homeostasis of mammary gland development and lactation are not clear. In the present study, sequencing data analysis of early and late lactation uncovered a total of 1,487 unique miRNAs, including 45 novel miRNA candidates and 1,442 known and conserved miRNAs, of which 758 miRNAs were co-expressed and 378 differentially expressed with P < 0...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927412/analysis-of-microrna-mirna-expression-profiles-reveals-11-key-biomarkers-associated-with-non-small-cell-lung-cancer
#14
Ke Wang, Mingwei Chen, Wei Wu
BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for more than 85% of lung cancer cases which cause most of cancer-related deaths globally. However, the results vary largely in different studies due to different platforms and sample sizes. Here, we aim to identify the key miRNAs in the carcinogenesis of NSCLC that might be potential biomarkers for this cancer. METHODS: Meta-analysis was performed on miRNA profile using seven datasets of NSCLC studies. Furthermore, we predicted and investigated the functions of genes regulated by key miRNAs...
September 19, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28899404/extracellular-vesicle-packaged-mirna-release-after-short-term-exposure-to-particulate-matter-is-associated-with-increased-coagulation
#15
Laura Pergoli, Laura Cantone, Chiara Favero, Laura Angelici, Simona Iodice, Eva Pinatel, Mirjam Hoxha, Laura Dioni, Marilena Letizia, Benedetta Albetti, Letizia Tarantini, Federica Rota, Pier Alberto Bertazzi, Amedea Silvia Tirelli, Vincenza Dolo, Andrea Cattaneo, Luisella Vigna, Cristina Battaglia, Michele Carugno, Matteo Bonzini, Angela Cecilia Pesatori, Valentina Bollati
BACKGROUND: Exposure to particulate matter (PM) is associated with increased incidence of cardiovascular disease and increased coagulation, but the molecular mechanisms underlying these associations remain unknown. Obesity may increase susceptibility to the adverse effects of PM exposure, exacerbating the effects on cardiovascular diseases. Extracellular vesicles (EVs), which travel in body fluids and transfer microRNAs (miRNAs) between tissues, might play an important role in PM-induced cardiovascular risk...
August 24, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28890884/circulating-mir-92a-mir-143-and-mir-342-in-plasma-are-novel-potential-biomarkers-for-acute-myeloid-leukemia
#16
Amr Rafat Elhamamsy, Muhammad Suleiman El Sharkawy, Ahmed Farouk Zanaty, Mohammed Ahmed Mahrous, Ahmed Ezzat Mohamed, Eslam Ahmed Abushaaban
MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional gene expression regulators. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. Recent studies have opened the way for the use of circulating miRNAs as non-invasive diagnosis and prognosis of Acute myeloid leukemia (AML). The aim of this study was to identify plasma miR-92a, miR-143 and miR-342 expression signatures in AML patients to introduce new markers for establishing AML diagnosis and prognosis...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28889064/spiroplasma-eriocheiris-induces-mouse-3t6-swiss-albino-cell-apoptosis-that-associated-with-the-infection-mechanism
#17
Libo Hou, Wei Gu, Huanxi Zhu, Wei Yao, Wen Wang, Qingguo Meng
Spiroplasma eriocheiris is a novel pathogen similar to the Spiroplasma mirum and also had an ability to infect the newborn mice and caused cataract. Our study was designed to study how S. eriocheiris infects mouse 3T6-Swiss albino cells and to elucidate the cellular molecular pathogenesis of Spiroplasma. FCM analysis and MTT analysis clearly shown that S. eriocheiris could induce 3T6 cell apoptosis and cause cell viability decreased seriously. Immunofluorescence experiments and TEM analysis shown that S. eriocheiris can invade 3T6 cells and form typical inclusion bodies and exhibit vacuolization in vitro...
November 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28887629/microrna-143-promotes-cardiac-ischemia-mediated-mitochondrial-impairment-by-the-inhibition-of-protein-kinase-cepsilon
#18
Hong Hong, Ting Tao, Si Chen, Chaoqi Liang, Yue Qiu, Yuhong Zhou, Rong Zhang
The cardioprotection of protein kinase Cepsilon (PKCε) against myocardial infarction (MI) mediated by its anti-apoptotic property and underlying mechanism of targeted regulation by microRNA (miRNA) are not established. MI-induced injury, PKCε expression, and targeted regulation of miRNA-143 (miR-143) to PKCε have been evaluated using animal MI and cellular hypoxic models conjugated with series of state-of-art molecular techniques. The results demonstrated that PKCε significantly downregulated along with increased infarcted area and apoptotic and necrotic damage in MI model, and the targeted relationship and potential binding profile were established between miR-143 and PKCε...
September 8, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28874710/effects-of-toxic-microcystis-aeruginosa-on-the-silver-carp-hypophthalmichtys-molitrix-revealed-by-hepatic-rna-seq-and-mirna-seq
#19
Menghong Hu, Xiancheng Qu, Lisha Pan, Chunxue Fu, Peixuan Jia, Qigen Liu, Youji Wang
High-throughput sequencing was applied to analyze the effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichthys molitrix. Silver carps were exposed to two cyanobacteria species (toxic and non-toxic) for RNA-seq and miRNA-seq analysis. RNA-seq revealed that the liver tissue contained 105,379 unigenes. Of these genes, 143 were significantly differentiated, 82 were markedly up-regulated, and 61 were remarkably down-regulated. GO term enrichment analysis indicated that 35 of the 154 enriched GO terms were significantly enriched...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871468/microrna-expression-in-the-locus-coeruleus-entorhinal-cortex-and-hippocampus-at-early-and-middle-stages-of-braak-neurofibrillary-tangle-pathology
#20
Franc Llorens, Katrin Thüne, Pol Andrés-Benito, Waqas Tahir, Belén Ansoleaga, Karina Hernández-Ortega, Eulàlia Martí, Inga Zerr, Isidro Ferrer
The present study analyzes by RT-qPCR the expression of microRNA (miRNA)-27a-3p, miRNA-124-3p, miRNA-132-3p, and miRNA-143-3p in the locus coeruleus (LC), entorhinal cortex (EC), CA1 region of the hippocampus (CA1), and dentate gyrus (DG) of middle-aged (MA) individuals with no brain lesions and of cases at Braak and Braak stages I-II and II-IV of neurofibrillary tangle (NFT) pathology. The most affected region is the LC in which miRNA-27a-3p, miRNA-124-3p, and miRNA-143-3p show a trend to increase at stages I-II and are significantly up-regulated at stages III-IV when compared with MA...
October 2017: Journal of Molecular Neuroscience: MN
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