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Mirna 143

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https://www.readbyqxmd.com/read/28187958/expression-of-oncogenic-mir-17-92-and-tumor-suppressive-mir-143-145-clusters-in-basal-cell-carcinoma-and-cutaneous-squamous-cell-carcinoma
#1
Michael Sand, Schapoor Hessam, Susanne Amur, Marina Skrygan, Michael Bromba, Eggert Stockfleth, Thilo Gambichler, Falk G Bechara
BACKGROUND: A variety of cancers are associated with the expression of the oncogenic miR-17-92 cluster (Oncomir-1) and tumor suppressor miR-143-5p/miR-145-5p. Epidermal skin cancer has not been investigated for the expression of miR-17-92 and miR-143-145 clusters, despite being extensively studied regarding global microRNA profiles. The goal of this study was to investigate the expression and possible correlation of expression of miR17-92 and miR-143-145 cluster members in epidermal skin cancer...
January 31, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28131796/alterations-in-microrna-expression-in-the-tissues-of-silver-carp-hypophthalmichthys-molitrix-following-microcystin-lr-exposure
#2
Yiyi Feng, Junguo Ma, Ruichen Xiang, Xiaoyu Li
In the field of toxicology, the relationship between microRNAs (miRNAs) and microcystin-LR (MC-LR) toxicity in fish is still poorly understood. In the present study, we used quantitative real-time PCR (qPCR) to examine the expression of 7 miRNAs (let-7b, miR-21, miR-122, miR-27b, miR-148, miR-125a, and miR-143) that play regulatory roles in biological processes such as signal transduction, apoptosis, cell cycle, and fatty acid metabolism. Expression patterns were assessed in the liver, spleen, and kidney of silver carp following 8, 24, and 48 h of exposure to MC-LR via intraperitoneal injection (50 or 200 μg/kg of body weight)...
January 25, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28123579/mir-143-inhibits-bladder-cancer-cell-proliferation-and-enhances-their-sensitivity-to-gemcitabine-by-repressing-igf-1r-signaling
#3
Hengbing Wang, Qi Li, Xiaobing Niu, Gongcheng Wang, Sinian Zheng, Guangbo Fu, Zengjun Wang
microRNAs (miRNAs) are a class of small RNAs that regulate gene expression. It has been demonstrated that aberrant miRNA expression is associated with cancer development and carcinogenesis. Altered miRNA expression has been suggested to occur in bladder cancer. In other cancer systems, studies have indicated that miR-143, as a tumor suppressor gene, plays essential roles in cancer progression. However, its role in bladder cancer has yet to be elucidated. In the present study, we observed that miR-143 expression was downregulated in human bladder cancer tissues and cells, and that its levels were negatively correlated with bladder cancer clinical stages...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28119089/the-p53-protein-induces-stable-mirnas-that-have-the-potential-to-modify-subsequent-p53-responses
#4
Miguel A Cabrita, Reetesh Bose, Erin J Vanzyl, Alyssa Pastic, Kristen A Marcellus, Elysia Pan, Jeff D Hamill, Bruce C McKay
The p53 tumour suppressor is a transcription factor that can increase the expression of mRNAs and microRNAs (miRNAs). HT29-tsp53 cells expressing a temperature sensitive variant of p53 have provided a useful model to rapidly and reversibly control p53 activity. In this model, the majority of p53-responsive mRNAs were upregulated rapidly but they were short-lived leading to rapid decay of the p53 response at the restrictive temperature. Here we used oligonucleotide microarrays and reverse transcriptase PCR to show that p53-induced miRNAs exhibited a distinct temporal pattern of expression...
January 21, 2017: Gene
https://www.readbyqxmd.com/read/28114622/association-between-serum-micrornas-and-magnetic-resonance-imaging-measures-of-multiple-sclerosis-severity
#5
Keren Regev, Brian C Healy, Fariha Khalid, Anu Paul, Renxin Chu, Shahamat Tauhid, Subhash Tummala, Camilo Diaz-Cruz, Radhika Raheja, Maria A Mazzola, Felipe von Glehn, Pia Kivisakk, Sheena L Dupuy, Gloria Kim, Tanuja Chitnis, Howard L Weiner, Roopali Gandhi, Rohit Bakshi
Importance: MicroRNAs (miRNAs) are promising multiple sclerosis (MS) biomarkers. Establishing the association between miRNAs and magnetic resonance imaging (MRI) measures of disease severity will help define their significance and potential impact. Objective: To correlate circulating miRNAs in the serum of patients with MS to brain and spinal MRI. Design, Setting, and Participants: A cross-sectional study comparing serum miRNA samples with MRI metrics was conducted at a tertiary MS referral center...
January 23, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28109198/mir-143-induces-the-apoptosis-of-prostate-cancer-lncap-cells-by-suppressing-bcl-2-expression
#6
Zhiwei Ma, Yizhao Luo, Mingxing Qiu
BACKGROUND Prostate cancer has become a serious threat to the life of patients. microRNAs are small non-coding RNA molecules that regulate the growth and apoptosis of cells. We aimed to investigate the regulation and mechanism of microRNA (miR-143) in the proliferation and apoptosis of prostate cancer LNCap cells. MATERIAL AND METHODS miR-143 and control scramble miRNA were synthesized and respectively transfected into LNCap cells. The proliferation and apoptosis were detected by MTT assay, flow cytometry, and caspase-3 activity assay...
January 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28101165/functions-of-microrna-143-in-the-apoptosis-invasion-and-migration-of-nasopharyngeal-carcinoma
#7
Jin-Hui Chen, Rui Yang, Wei Zhang, Yong-Ping Wang
Nasopharyngeal carcinoma (NPC) is a common cancer characterized by poor prognosis in areas of Southern China where it is endemic. microRNAs (miRNAs) are a class of naturally occurring small noncoding RNAs, some of which contribute to the initiation and development of cancer. The current study was designed to examine the expression level of miR-143 in NPC tissues. The potential functional targets of miR-143 involved in tumor apoptosis, invasion and migration were also investigated. Reverse transcription-quantitative polymerase chain reaction was used to evaluate the expression levels of miR-143 in clinical NPC specimens...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28057086/diagnostic-value-of-microrna-143-in-predicting-in-stent-restenosis-for-patients-with-lower-extremity-arterial-occlusive-disease
#8
Zhi-Hai Yu, Hai-Tao Wang, Can Tu
PURPOSE: This study was conducted to explore the diagnostic value of microRNA-143 (miRNA-143) in predicting in-stent restenosis (ISR) of lower extremity arterial occlusive disease (LEAOD). METHODS: From February 2012 to March 2015, 165 patients (112 males and 53 females) with LEAOD undergoing interventional treatment were enrolled in this study. Serum miRNA-143 expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Patients were assigned into the restenosis and non-restenosis groups according to routine surveillance postoperative angiography...
January 5, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28054243/differential-expression-and-mirna-regulation-of-the-gstp1-gene-in-the-regenerating-liver-of-chiloscyllium-plagiosum
#9
Yinghua Ge, Jiewen Zhang, Xinyi Shi, Conger Lu, Lingrong Yang, Yuanyuan Li, Yanna Chen, Dandan Cheng, Jing Bai, Zhengbing Lv, Lili Liu
Liver regeneration is a complicated process, and understanding the regulatory mechanism will be helpful in the treatment of diseases associated with liver. In this study, the one-third liver resection model was established in Chiloscyllium plagiosum, and the whole transcriptome of the C. plagiosum was generated using the Illumina-Solexa sequencing platform. Differentially expressed genes were analyzed using bioinformatics methods and verified using quantitative real-time PCR (qRT-PCR). Using miRanda and TargetScan, we screened the microRNA library for miRNAs that target the glutathione S-transferase P1(GSTP1) gene...
January 4, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28036291/assessing-the-clinical-value-of-micrornas-in-formalin-fixed-paraffin-embedded-liposarcoma-tissues-overexpressed-mir-155-is-an-indicator-of-poor-prognosis
#10
Nikolaos Kapodistrias, Konstantinos Mavridis, Anna Batistatou, Penelope Gogou, Vasilios Karavasilis, Ioannis Sainis, Evangelos Briasoulis, Andreas Scorilas
Liposarcoma (LPS) is a malignancy with extreme heterogeneity and thus optimization towards personalizing patient prognosis and treatment is essential. Here, we evaluated miR-155, miR-21, miR-143, miR-145 and miR-451 that are implicated in LPS, as novel FFPE tissue biomarkers.A total of 83 FFPE tissue specimens from primary LPS and lipomas (LPM) were analyzed. A proteinase K incubation-Trizol treatment coupled protocol was used for RNA isolation. After polyadenylation of total RNA and reverse transcription, expression analysis of 9 candidate reference and 5 target miRNAs was performed by qPCR...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/27951581/micrornas-are-associated-with-uremic-toxicity-cardiovascular-calcification-and-disease
#11
Ziad A Massy, Valérie Metzinger-Le Meuth, Laurent Metzinger
BACKGROUND: Vascular calcification has been recognized to be a major risk factor in chronic kidney disease (CKD) and downstream cardiovascular complications. Micro-RNAs (miRNAs) are small noncoding RNAs comprising 20-25 nucleotides that regulate gene expression by inhibiting or degrading the target mRNA, and constitute potential new biomarkers and future therapeutic strategies. SUMMARY: We tested the relevance of several cardiovascular-specific miRNAs as new biomarkers for CKD, cardiovascular disease, and cardiovascular complications...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/27939432/regulation-of-microrna-expression-in-vascular-smooth-muscle-by-mrtf-a-and-actin-polymerization
#12
Azra Alajbegovic, Karolina M Turczyńska, Tran Thi Hien, Pilar Cidad, Karl Swärd, Per Hellstrand, Alessandro Della Corte, Amalia Forte, Sebastian Albinsson
The dynamic properties of the actin cytoskeleton in smooth muscle cells play an important role in a number of cardiovascular disease states. The state of actin does not only mediate mechanical stability and contractile function but can also regulate gene expression via myocardin related transcription factors (MRTFs). These transcriptional co-activators regulate genes encoding contractile and cytoskeletal proteins in smooth muscle. Regulation of small non-coding microRNAs (miRNAs) by actin polymerization may mediate some of these effects...
December 8, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27927764/circulating-microrna-are-predictive-of-aging-and-acute-adaptive-response-to-resistance-exercise-in-men
#13
Lee M Margolis, Sarah J Lessard, Yassine Ezzyat, Roger A Fielding, Donato A Rivas
Circulating microRNA (c-miRNA) have the potential to function as novel noninvasive markers of the underlying physiological state of skeletal muscle. This investigation sought to determine the influence of aging on c-miRNA expression at rest and following resistance exercise in male volunteers (Young: n = 9; Older: n = 9). Primary findings were that fasting c-miRNA expression profiles were significantly predictive of aging, with miR-19b-3p, miR-206, and miR-486 distinguishing between age groups. Following resistance exercise, principal component analysis revealed a divergent response in expression of 10 c-miRNA, where expression profiles were upregulated in younger and downregulated in older participants...
December 7, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27917915/blood-hsa-mir-122-5p-and-hsa-mir-885-5p-levels-associate-with-fatty-liver-and-related-lipoprotein-metabolism-the-young-finns-study
#14
Emma Raitoharju, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Jorma Viikari, Mika Ala-Korpela, Pasi Soininen, Antti J Kangas, Melanie Waldenberger, Norman Klopp, Thomas Illig, Jaana Leiviskä, Britt-Marie Loo, Niku Oksala, Mika Kähönen, Nina Hutri-Kähönen, Reijo Laaksonen, Olli Raitakari, Terho Lehtimäki
MicroRNAs are involved in disease development and may be utilized as biomarkers. We investigated the association of blood miRNA levels and a) fatty liver (FL), b) lipoprotein and lipid pathways involved in liver lipid accumulation and c) levels of predicted mRNA targets in general population based cohort. Blood microRNA profiling (TaqMan OpenArray), genome-wide gene expression arrays and nuclear magnetic resonance metabolomics were performed for Young Finns Study participants aged 34-49 years (n = 871)...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27906435/down-regulation-of-microrna-143-is-associated-with-colorectal-cancer-progression
#15
J-W Bai, H-Z Xue, C Zhang
OBJECTIVE: Colorectal cancer (CRC) is one of the most prevalent carcinomas worldwide. Tumor metastasis and recurrence are leading causes of CRC-related deaths. Given the role of microRNA (miRNA) in CRC invasion and metastasis, we explored the association between miRNA-143 expression and clinicopathologic characteristics in CRC, as well as the effects of miRNA-143 on CRC cell invasion in vitro. MATERIALS AND METHODS: Quantitative real-time PCR was conducted to assess the expression of miR-143 in tissue specimens and cell lines...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27878762/mir-cluster-143-145-directly-targets-nrl-and-regulates-rod-photoreceptor-development
#16
Sreekumaran Sreekanth, Vazhanthodi A Rasheed, Lalitha Soundararajan, Jayesh Antony, Minakshi Saikia, Krishnankutty Chandrika Sivakumar, Ani V Das
Retinal histogenesis requires coordinated and temporal functioning of factors by which different cell types are generated from multipotent progenitors. Development of rod photoreceptors is regulated by multiple transcription factors, and Nrl is one of the major factors involved in their fate specification. Presence or absence of Nrl at the postnatal stages decides the generation of cone photoreceptors or other later retinal cells. This suggests the need for regulated expression of Nrl in order to accelerate the generation of other cell types during retinal development...
November 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27833019/changes-in-serum-mirnas-following-generalized-convulsive-seizures-in-human-mesial-temporal-lobe-epilepsy
#17
Rainer Surges, Anita Kretschmann, Khalid Abnaof, Marijke van Rikxoort, Kirsten Ridder, Holger Fröhlich, Bénédicte Danis, Rafal M Kaminski, Patrik Foerch, Christian E Elger, Frank Weinsberg, Alexander Pfeifer
MicroRNAs (miRNAs) are key regulators of gene expression and are involved in the pathomechanisms of epilepsy. MiRNAs may also serve as peripheral biomarkers of epilepsy. We investigated the miRNA profile in the blood serum of patients suffering from mesial temporal lobe epilepsy (mTLE) following a single focal seizure evolving to a bilateral convulsive seizure (BCS) during video-EEG monitoring. Data of 15 patients were included in the final analysis. MiRNA expression was determined using Real Time-PCR followed by thorough bioinformatical analysis of expression levels...
December 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27832764/blood-mirnomes-and-transcriptomes-reveal-novel-longevity-mechanisms-in-the-long-lived-bat-myotis-myotis
#18
Zixia Huang, David Jebb, Emma C Teeling
BACKGROUND: Chiroptera, the bats, are the only order of mammals capable of true self-powered flight. Bats exhibit a number of other exceptional traits such as echolocation, viral tolerance and, perhaps most puzzlingly, extreme longevity given their body size. Little is known about the molecular mechanisms driving their extended longevity particularly at the levels of gene expression and post-transcriptional regulation. To elucidate the molecular mechanisms that may underlie their unusual longevity, we have deep sequenced 246...
November 10, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27827523/microrna-143-inhibits-colorectal-cancer-cell-proliferation-by-targeting-mmp7
#19
Bing Yu, Xuezhong Liu, Hong Chang
BACKGROUND: MicroRNAs (miRNAs) play critical roles in the development and progression of human malignancy. The levels of miR-143 microRNA are lower in malignant tumors - including colorectal cancer (CRC) - as it is a tumor suppressor. However, the potential mechanism of miR-143 in CRC remains largely unknown. METHODS: Target prediction programs and luciferase reporter assay was used to predict the targets of miR-143. Following overexpression of miR-143 in CRC cells, target gene matrix metalloproteinase 7 (MMP7) expression was detected by quantitative real-time PCR (qRT-PCR) and western blot...
February 2017: Minerva Medica
https://www.readbyqxmd.com/read/27824155/cucurbitacin-d-exhibits-potent-anti-cancer-activity-in-cervical-cancer
#20
Mohammed Sikander, Bilal Bin Hafeez, Shabnam Malik, Abdulrhman Alsayari, Fathi T Halaweish, Murali M Yallapu, Subhash C Chauhan, Meena Jaggi
In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. Induction of apoptosis was observed in Cucurbitacin D treated cervical cancer cells as measured by enhanced Annexin V staining and cleavage in PARP protein...
November 8, 2016: Scientific Reports
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