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Mirna 143

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https://www.readbyqxmd.com/read/27906435/down-regulation-of-microrna-143-is-associated-with-colorectal-cancer-progression
#1
J-W Bai, H-Z Xue, C Zhang
OBJECTIVE: Colorectal cancer (CRC) is one of the most prevalent carcinomas worldwide. Tumor metastasis and recurrence are leading causes of CRC-related deaths. Given the role of microRNA (miRNA) in CRC invasion and metastasis, we explored the association between miRNA-143 expression and clinicopathologic characteristics in CRC, as well as the effects of miRNA-143 on CRC cell invasion in vitro. MATERIALS AND METHODS: Quantitative real-time PCR was conducted to assess the expression of miR-143 in tissue specimens and cell lines...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27878762/mir-cluster-143-145-directly-targets-nrl-and-regulates-rod-photoreceptor-development
#2
Sreekumaran Sreekanth, Vazhanthodi A Rasheed, Lalitha Soundararajan, Jayesh Antony, Minakshi Saikia, Krishnankutty Chandrika Sivakumar, Ani V Das
Retinal histogenesis requires coordinated and temporal functioning of factors by which different cell types are generated from multipotent progenitors. Development of rod photoreceptors is regulated by multiple transcription factors, and Nrl is one of the major factors involved in their fate specification. Presence or absence of Nrl at the postnatal stages decides the generation of cone photoreceptors or other later retinal cells. This suggests the need for regulated expression of Nrl in order to accelerate the generation of other cell types during retinal development...
November 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27833019/changes-in-serum-mirnas-following-generalized-convulsive-seizures-in-human-mesial-temporal-lobe-epilepsy
#3
Rainer Surges, Anita Kretschmann, Khalid Abnaof, Marijke van Rikxoort, Kirsten Ridder, Holger Fröhlich, Bénédicte Danis, Rafal M Kaminski, Patrik Foerch, Christian E Elger, Frank Weinsberg, Alexander Pfeifer
MicroRNAs (miRNAs) are key regulators of gene expression and are involved in the pathomechanisms of epilepsy. MiRNAs may also serve as peripheral biomarkers of epilepsy. We investigated the miRNA profile in the blood serum of patients suffering from mesial temporal lobe epilepsy (mTLE) following a single focal seizure evolving to a bilateral convulsive seizure (BCS) during video-EEG monitoring. Data of 15 patients were included in the final analysis. MiRNA expression was determined using Real Time-PCR followed by thorough bioinformatical analysis of expression levels...
December 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27832764/blood-mirnomes-and-transcriptomes-reveal-novel-longevity-mechanisms-in-the-long-lived-bat-myotis-myotis
#4
Zixia Huang, David Jebb, Emma C Teeling
BACKGROUND: Chiroptera, the bats, are the only order of mammals capable of true self-powered flight. Bats exhibit a number of other exceptional traits such as echolocation, viral tolerance and, perhaps most puzzlingly, extreme longevity given their body size. Little is known about the molecular mechanisms driving their extended longevity particularly at the levels of gene expression and post-transcriptional regulation. To elucidate the molecular mechanisms that may underlie their unusual longevity, we have deep sequenced 246...
November 10, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27827523/microrna-143-inhibits-colorectal-cancer-cell-proliferation-through-targeting-mmp7
#5
Bing Yu, Xuezhong Liu, Hong Chang
BACKGROUND: MicroRNAs (miRNAs) play critical roles in the development and progression of human malignancy. MiR-143 as a tumor suppressor, is decreased in malignant tumors, including colorectal cancer (CRC). However, the potential mechanism of miR-143 in CRC remains largely unknown. METHODS: Target prediction programs and luciferase reporter assay was used to predict the targets of miR-143. Following overexpression of miR-143 in CRC cells, target gene matrix metallopeptidase 7(MMP7) expression was detected by quantitative real-time PCR (qRT-PCR) and western blot...
November 9, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27824155/cucurbitacin-d-exhibits-potent-anti-cancer-activity-in-cervical-cancer
#6
Mohammed Sikander, Bilal Bin Hafeez, Shabnam Malik, Abdulrhman Alsayari, Fathi T Halaweish, Murali M Yallapu, Subhash C Chauhan, Meena Jaggi
In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. Induction of apoptosis was observed in Cucurbitacin D treated cervical cancer cells as measured by enhanced Annexin V staining and cleavage in PARP protein...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27810075/co-localized-genomic-regulation-of-mirna-and-mrna-via-dna-methylation-affects-survival-in-multiple-tumor-types
#7
James D Doecke, Ying Wang, Keith Baggerly
Aberrant gene expression in cancer is due in part to irregular patterns of DNA methylation and miRNA target gene down regulation. Using data from The Cancer Genome Atlas (TGCA), we investigated co-localized mRNA, miRNA and DNA methylation data across 15 cancer types, focusing on cases where evidence for direct regulation was strong. Restricting attention to regions where miRNA markers co-localize within a corresponding mRNA transcript, we checked expression data from 2839 samples for 354 mRNAs, 389 miRNAs and 13,809 DNA methylation probes for correlations greater than an absolute 0...
October 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27800570/mir-143-regulates-proliferation-and-differentiation-of-bovine-skeletal-muscle-satellite-cells-by-targeting-igfbp5
#8
Wei Ran Zhang, Hui Na Zhang, Yi Min Wang, Yang Dai, Xin Feng Liu, Xin Li, Xiang Bin Ding, Hong Guo
Development of skeletal muscle is a complicated biological process regulated by various regulation factors and signal pathways. MicroRNAs (miRNAs) are novel gene regulators that control muscle cell development. microRNA-143 (miR-143) is highly expressed in skeletal muscle, and we found that miR-143 level is significantly increased during bovine skeletal muscle satellite cells (MSCs) differentiation process through microarray analysis and qRT-PCR detection. However, the function of miR-143 in bovine muscle development remained unclear...
October 31, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27776879/expression-profiles-of-inflammation-associated-micrornas-in-periapical-lesions-and-human-periodontal-ligament-fibroblasts-inflammation
#9
Junli Yue, Dongzhe Song, Wanlu Lu, Ying Lu, Wei Zhou, Xuelian Tan, Lan Zhang, Dingming Huang
INTRODUCTION: microRNAs (miRNAs) have been identified to be closely related to inflammatory diseases. The aim of our study was to identify expression profiles of miRNAs associated with inflammation in apical periodontitis (AP) lesions and human periodontal ligament fibroblasts (HPDLFs) inflammation. METHODS: Total RNAs were extracted from 10 AP lesions, 6 control tissues, and HPDLFs using lysis buffer. Expressions of miRNAs (miR-29b, 106b, 125b, 143, 155, and 198) were detected by real-time polymerase chain reaction...
October 21, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27724902/identification-and-differential-regulation-of-micrornas-in-response-to-methyl-jasmonate-treatment-in-lycoris-aurea-by-deep-sequencing
#10
Sheng Xu, Yumei Jiang, Ning Wang, Bing Xia, Yilong Jiang, Xiaodan Li, Zhengzhi Zhang, Yikui Li, Ren Wang
BACKGROUND: Lycoris aurea is a medicine-valuable and ornamental herb widely distributed in China. Former studied have showed that methyl jasmonate (MJ) treatment could increase the content of glanthamine-a worldwide medicine for symptomatic treatment of Alzheimer's disease in genus Lycoris plants. To explore the possible role of miRNAs in the regulation of jasmonic acid signaling pathway and uncover their potential correlations, we investigated the expression profiles of small RNAs (sRNAs) and their targets in Lycoris aurea, with MJ treatment by using next-generation deep sequencing...
October 10, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27713147/mir-608-pre-mir-124-1-and-pre-mir26a-1-polymorphisms-modify-susceptibility-and-recurrence-free-survival-in-surgically-resected-crc-individuals
#11
Hou-Qun Ying, Hong-Xin Peng, Bang-Shun He, Yu-Qin Pan, Feng Wang, Hui-Ling Sun, Xian Liu, Jie Chen, Kang Lin, Shu-Kui Wang
Genetic variation within microRNA (miRNA) may result in its abnormal folding or aberrant expression, contributing to colorectal turmorigenesis and metastasis. However, the association of six polymorphisms (miR-608 rs4919510, miR-499a rs3746444, miR-146a rs2910164, pre-miR-143 rs41291957, pre-miR-124-1 rs531564 and pre-miR-26a-1 rs7372209) with colorectal cancer (CRC) risk, therapeutic response and survival remains unclear. A retrospective study was carried out to investigate the association in 1358 0-III stage resected CRC patients and 1079 healthy controls using Sequenom's MassARRAY platform...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27696070/microrna-126-and-micro-macrovascular-complications-of-type-1-diabetes-in-the-eurodiab-prospective-complications-study
#12
Federica Barutta, Graziella Bruno, Giuseppe Matullo, Nish Chaturvedi, Serena Grimaldi, Casper Schalkwijk, Coen D Stehouwer, John H Fuller, Gabriella Gruden
AIMS: Increasing evidence suggests a potential role of circulating miRNAs as clinical biomarkers, and loss of miRNA-126 has been proposed as a predictor of type 2 diabetes onset. However, a systematic analysis of circulating miRNAs in type 1 diabetic patients with micro-/macrovascular complications has not yet been performed. METHODS: A cross-sectional nested case-control study from the EURODIAB Prospective Complications Study of 455 type 1 diabetic patients was performed...
October 1, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27667995/mir-203-expression-in-exfoliated-cells-of-tongue-coating-represents-a-sensitive-and-specific-biomarker-of-gastroesophageal-reflux-disease
#13
Xiuli Yan, Shengliang Zhu, Hui Zhang
Background and Aim. MicroRNAs (miRNAs) have been implicated in the pathophysiology of numerous human diseases including gastroesophageal reflux disease (GERD). The objective of this study was to investigate the miRNA expression of exfoliated cells of the tongue in patients with GERD versus healthy controls (Ctrls). Methods. Using quantitative reverse-transcription PCR (qRT-PCR), expression levels of six candidate miRNAs (miR-143, miR-145, miR-192, miR-194, miR-203, and miR-205) were examined across a discovery cohort of patients with GERD (n = 24) versus Ctrls (n = 24)...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27662660/genomic-characterization-of-liver-metastases-from-colorectal-cancer-patients
#14
José María Sayagués, Luís Antonio Corchete, María Laura Gutiérrez, Maria Eugenia Sarasquete, María Del Mar Abad, Oscar Bengoechea, Encarna Fermiñán, María Fernanda Anduaga, Sofia Del Carmen, Manuel Iglesias, Carmen Esteban, María Angoso, Jose Antonio Alcazar, Jacinto García, Alberto Orfao, Luís Muñoz-Bellvis
Metastatic dissemination is the most frequent cause of death of sporadic colorectal cancer (sCRC) patients. Genomic abnormalities which are potentially characteristic of such advanced stages of the disease are complex and so far, they have been poorly described and only partially understood. We evaluated the molecular heterogeneity of sCRC tumors based on simultaneous assessment of the overall GEP of both coding mRNA and non-coding RNA genes in primary sCRC tumor samples from 23 consecutive patients and their paired liver metastases...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27639060/mir-143-3p-controls-tgf-%C3%AE-1-induced-cell-proliferation-and-extracellular-matrix-production-in-airway-smooth-muscle-via-negative-regulation-of-the-nuclear-factor-of-activated-t-cells-1
#15
Wei Cheng, Kun Yan, Li-Yi Xie, Feng Chen, Hong-Chuan Yu, Yan-Xia Huang, Cheng-Xue Dang
MicroRNAs (miRNAs) are small noncoding RNAs that function in diverse biological processes. However, little is known about the precise role of microRNAs in the functioning of airway smooth muscle cells (ASMCs). Here, we investigated the potential role and mechanisms of the miR-143 -3p on proliferation and the extracellular matrix (ECM) protein production of ASMCs. We demonstrated that miR-143-3p was aberrantly lower in ASMCs isolated from individuals with asthma than in individuals without asthma. Meanwhile, TGF-β1 caused a marked decrease in a time-dependent manner in miR-143-3p expression in ASMCs from asthmatics...
October 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27631489/differential-expression-of-micrornas-in-endarterectomy-specimens-taken-from-patients-with-asymptomatic-and-symptomatic-carotid-plaques
#16
Birgit Markus, Karsten Grote, Michael Worsch, Behnoush Parviz, Andreas Boening, Bernhard Schieffer, Mariana S Parahuleva
OBJECTIVE: Stroke and transient ischemic attacks are considered as clinical manifestations of atherosclerotic disease due to on-going vascular inflammation and finally atherothrombosis of the carotid arteries. MicroRNAs (miRNA/miR) are known to be involved in vascular inflammation and plaque destabilization. The aim of this study was to analyze the expression profile of selected miRNAs in endarterectomy specimen from carotid arteries that were taken from patients with asymptomatic and symptomatic atherosclerotic plaques...
2016: PloS One
https://www.readbyqxmd.com/read/27629291/study-of-apoptosis-related-interactions-in-colorectal-cancer
#17
Himanshu Arora, Rehana Qureshi, M A Rizvi, Sharad Shrivastava, Mordhwaj S Parihar
Abnormalities in apoptotic functions contribute to the pathogenesis of colorectal cancer. In this study, molecular interactions behind the apoptotic regulation have been explored. For this purpose, enrichment analysis was performed considering microRNAs (miRNAs) that putatively target TP53 and altered during colon cancer. This revealed gene associated with both TP53 and miRNAs. Further analysis showed that a significant molecular interaction between the shortlisted candidates (TP53, miR-143, KRAS, BCL2, and PLK1) exists...
September 15, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27613243/crucial-genes-associated-with-diabetic-nephropathy-explored-by-microarray-analysis
#18
Zhikui Wang, Zhaoxia Wang, Zhongqi Zhou, Yueqin Ren
BACKGROUND: This study sought to investigate crucial genes correlated with diabetic nephropathy (DN), and their potential functions, which might contribute to a better understanding of DN pathogenesis. METHODS: The microarray dataset GSE1009 was downloaded from Gene Expression Omnibus, including 3 diabetic glomeruli samples and 3 healthy glomeruli samples. The differentially expressed genes (DEGs) were identified by LIMMA package. Their potential functions were then analyzed by the GO and KEGG pathway enrichment analyses using the DAVID database...
2016: BMC Nephrology
https://www.readbyqxmd.com/read/27611973/profile-of-exosomal-and-intracellular-microrna-in-gamma-herpesvirus-infected-lymphoma-cell-lines
#19
Shiho Hoshina, Tsuyoshi Sekizuka, Michiyo Kataoka, Hideki Hasegawa, Hiromichi Hamada, Makoto Kuroda, Harutaka Katano
Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), encode miRNAs in their genomes and express virus-encoded miRNAs in cells and exosomes. However, there is little information about the detailed distribution of virus-encoded miRNAs in cells and exosomes. In this study, we thus identified virus- and host-encoded miRNAs in exosomes released from KSHV- or EBV-infected lymphoma cell lines and compared them with intracellular miRNAs using a next-generation sequencer...
2016: PloS One
https://www.readbyqxmd.com/read/27606420/potential-significance-of-circular-rna-in-human-placental-tissue-for-patients-with-preeclampsia
#20
Yating Qian, Yuanqing Lu, Can Rui, Yujia Qian, Manhong Cai, Ruizhe Jia
AIMS: This study aimed to identify the different expression of circular RNAs (circRNAs) in the placental tissues of pregnant women with preeclampsia (PE) and to provide a new avenue of research regarding the pathological mechanisms of PE. METHODS: In this study, we collected 40 placental tissues from PE patients and 35 placental tissues from gestational age-matched patients who gave premature birth. Arraystar circRNA Microarray Technology (KANGCHEN, Shanghai, China) was used to analyze the differential expression of circRNAs...
2016: Cellular Physiology and Biochemistry
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