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https://www.readbyqxmd.com/read/28100310/growth-inhibition-of-fungus-phycomyces-blakesleeanus-by-anion-channel-inhibitors-anthracene-9-carboxylic-and-niflumic-acid-attained-through-decrease-in-cellular-respiration-and-energy-metabolites
#1
Marina Stanić, Strahinja Križak, Mirna Jovanović, Tanja Pajić, Ana Ćirić, Milan Žižić, Joanna Zakrzewska, Tijana Cvetić Antić, Nataša Todorović, Miroslav Živić
Increasing resistance of fungal strains to known fungicides has prompted identification of new candidates for fungicides among substances previously used for other purposes. We have tested the effects of known anion channel inhibitors anthracene-9-carboxylic (A9C) and niflumic acid (NFA) on growth, energy metabolism and anionic current of mycelium of fungus Phycomyces blakesleeanus. Both inhibitors significantly decreased growth and respiration of mycelium, but complete inhibition was only achieved by 100 or 500 µM NFA, for growth and respiration, respectively...
January 18, 2017: Microbiology
https://www.readbyqxmd.com/read/28008641/effects-of-mirnas-on-myocardial-apoptosis-by-modulating-mitochondria-related-proteins
#2
REVIEW
Yanfang Zhao, Murugavel Ponnusamy, Yanhan Dong, Lei Zhang, Kun Wang, Peifeng Li
Myocardial apoptosis play a vital role in pathogenesis of cardiovascular diseases. The intrinsic pathway of apoptosis (mitochondrial apoptosis pathway) and abnormal mitochondrial fission and fusion have a detrimental effect on cells under a variety of intracellular stresses including hypoxia, oxidative stress, drug toxicity or DNA damage and contributes to the development of heart failure (HF), myocardial infarction (MI), diabetic cardiomyopathy and ischemia/reperfusion injury (I/R). MicroRNAs (miRNAs) are endogenous short noncoding RNAs, which target 3'-untranslated region of mRNA to switch off gene expression...
December 23, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28004114/mir-20a-directed-regulation-of-bid-is-associated-with-the-trail-sensitivity-in-colorectal-cancer
#3
Guanli Huang, Xiangjian Chen, Yefeng Cai, Xiaobo Wang, Chungen Xing
MicroRNAs (miRNAs) are small, non-coding RNAs that play important roles in cancer processes. Although miR-20a has been reported to be altered in a range of cancers, the role of miR-20a in colorectal cancer is not fully characterized, and the relationship between miR-20a dysregulation and the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity is not defined. In the present study, we demonstrated significant upregulation of miR-20a in the serum of colorectal cancer patients, tumor tissues and cell lines by quantitative RT-PCR analysis...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27974319/microrna-30e-targets-bnip3l-to-protect-against-aldosterone-induced-podocyte-apoptosis-and-mitochondrial-dysfunction
#4
Yan Guo, Xu Deng, Shuang Chen, Lingyun Yang, Jiajia Ni, Rong Wang, Jiajuan Lin, Mi Bai, Zhanjun Jia, Songming Huang, Aihua Zhang
MicroRNAs (miRNAs) are essential for the maintenance of podocyte homeostasis. Emerging evidence demonstrated a protective role of miRNA-30a, a member of miR-30 family in podocyte injury. However, the role of other members of miR-30 family in podocyte injury is unclear. The present study was undertaken to investigate the contribution of miR-30e in the pathogenesis of podocyte injury induced by aldosterone (Aldo), as well as the underlying mechanism. Following Aldo treatment, miR-30e was dose-and time-dependently reduced...
December 14, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27941687/low-dose-methylmercury-induced-genes-regulate-mitochondrial-biogenesis-via-mir-25-in-immortalized-human-embryonic-neural-progenitor-cells
#5
Xinjin Wang, Mengling Yan, Lina Zhao, Qing Wu, Chunhua Wu, Xiuli Chang, Zhijun Zhou
Mitochondria are essential organelles and important targets for environmental pollutants. The detection of mitochondrial biogenesis and generation of reactive oxygen species (ROS) and p53 levels following low-dose methylmercury (MeHg) exposure could expand our understanding of underlying mechanisms. Here, the sensitivity of immortalized human neural progenitor cells (ihNPCs) upon exposure to MeHg was investigated. We found that MeHg altered cell viability and the number of 5-ethynyl-2'-deoxyuridine (EdU)-positive cells...
December 9, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27929108/human-adipose-mesenchymal-stem-cell-derived-exosomal-mirnas-are-critical-factors-for-inducing-anti-proliferation-signalling-to-a2780-and-skov-3-ovarian-cancer-cells
#6
Abu Musa Md Talimur Reza, Yun-Jung Choi, Hideyo Yasuda, Jin-Hoi Kim
An enigmatic question exists concerning the pro- or anti-cancer status of mesenchymal stem cells (MSCs). Despite growing interest, this question remains unanswered, and the debate became intensified with new evidences backing each side. Here, we showed that human adipose MSC (hAMSC)-derived conditioned medium (CM) exhibited inhibitory effects on A2780 human ovarian cancer cells by blocking the cell cycle, and activating mitochondria-mediated apoptosis signalling. Explicitly, we demonstrated that exosomes, an important biological component of hAMSC-CM, could restrain proliferation, wound-repair and colony formation ability of A2780 and SKOV-3 cancer cells...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913682/translational-regulation-of-mitochondrial-biogenesis
#7
REVIEW
Yi Zhang, Hong Xu
Mitochondria are generated by the expression of genes on both nuclear and mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to cellular energy demand, developmental signals and environmental stimuli. Mechanistic target of rapamycin (mTOR) pathway regulates mitochondrial biogenesis to co-ordinate energy homeostasis with cell growth. The local translation of mitochondrial proteins on the outer membrane facilitates their efficient import and thereby allows prodigious mitochondrial biogenesis during rapid cell growth and proliferation...
December 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27885275/tdb-protects-vascular-endothelial-cells-against-oxygen-glucose-deprivation-reperfusion-induced-injury-by-targeting-mir-34a-to-increase-bcl-2-expression
#8
Li-Xi Liao, Ming-Bo Zhao, Xin Dong, Yong Jiang, Ke-Wu Zeng, Peng-Fei Tu
Prolonged ischemia can result in apoptotic death of vascular endothelial cells and lead to ischemic vascular diseases including vascular dementia, arteriosclerosis and brain oedema. Finding protective strategies to prevent this is therefore an urgent mission. Recent studies have shown that dysregulation of microRNAs (miRNAs) can lead to imbalance of Bcl-2 family proteins and mitochondrial dysfunction, leading to further damage of vascular cells under ischemic conditions. However, whether miRNAs can be used as a drug target for treating vascular diseases is not fully understood...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27799943/mesenchymal-stromal-cells-derived-extracellular-vesicles-ameliorate-acute-renal-ischemia-reperfusion-injury-by-inhibition-of-mitochondrial-fission-through-mir-30
#9
Di Gu, Xiangyu Zou, Guanqun Ju, Guangyuan Zhang, Erdun Bao, Yingjian Zhu
Background. The immoderation of mitochondrial fission is one of the main contributors in ischemia reperfusion injury (IRI) and mesenchymal stromal cells (MSCs) derived extracellular vesicles have been regarded as a potential therapy method. Here, we hypothesized that extracellular vesicles (EVs) derived from human Wharton Jelly mesenchymal stromal cells (hWJMSCs) ameliorate acute renal IRI by inhibiting mitochondrial fission through miR-30b/c/d. Methods. EVs isolated from the condition medium of MCS were injected intravenously in rats immediately after monolateral nephrectomy and renal pedicle occlusion for 45 minutes...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27748833/the-effect-of-dichloroacetate-in-canine-prostate-adenocarcinomas-and-transitional-cell-carcinomas-in-vitro
#10
Tatjana Harting, Mandy Stubbendorff, Saskia Willenbrock, Siegfried Wagner, Patrik Schadzek, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte
The Warburg effect describes the ability of cancer cells to produce energy via aerobic glycolysis instead of oxidative phosphorylation of pyruvate. This deviation in mitochondrial metabolism inhibits apoptosis, allowing increased proliferation under conditions of reduced oxygen levels. Dichloroacetate (DCA) was successfully used in several human cancer cell lines to reactivate oxidative phosphorylation in mitochondria. The aim of this study was the characterization and response of canine cancer cell lines after DCA exposure...
December 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27742689/role-of-microrna-in-metabolic-shift-during-heart-failure
#11
REVIEW
Mark V Pinti, Quincy A Hathaway, John M Hollander
Heart failure (HF) is an end point resulting from a number of disease states. The prognosis for HF patients is poor with survival rates precipitously low. Energy metabolism is centrally linked to the development of HF, and it involves the proteomic remodeling of numerous pathways, many of which are targeted to the mitochondrion. microRNAs (miRNA) are noncoding RNAs that influence posttranscriptional gene regulation. miRNA have garnered considerable attention for their ability to orchestrate changes to the transcriptome, and ultimately the proteome, during HF...
January 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27736004/role-of-micrornas-on-the-regulation-of-mitochondrial-biogenesis-and-insulin-signaling-in-skeletal-muscle
#12
REVIEW
Tanes I Lima, Hygor N Araujo, Eveline S Menezes, Carlos H Sponton, Michel B Araújo, Lucas H M Bomfim, André L Queiroz, Madla A Passos, Thais Amaral E Sousa, Sandro M Hirabara, Amanda R Martins, Helena C L B Sampaio, Alice Rodrigues, Rui Curi, Everardo M Carneiro, Antônio C Boschero, Leonardo R Silveira
Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic diseases such as obesity and type 2 diabetes. MicroRNAs are non-coding RNAs that have emerged as key regulators of cell metabolism. The microRNAs act as central regulators of metabolic gene networks by leading to the degradation of their target messenger RNA or repression of protein translation. In addition, vesicular and non-vesicular circulating miRNAs exhibit a potential role as mediators of the cross-talk between the skeletal muscle and other tissues/organs...
May 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27681638/mir-24-bim-smac-diablo-axis-controls-the-sensitivity-to-doxorubicin-treatment-in-osteosarcoma
#13
Yangbai Sun, Nengbin He, Yang Dong, Chaoyin Jiang
Emerging evidence shows that microRNAs (miRNAs) act as critical regulators in the progression and chemoresistance of multiple tumors, including osteosarcoma (OS). In this study, we found that the level of miR-24 was increased in OS patients' serum, tumor tissues and OS cell lines. Furthermore, we found that knockdown of miR-24 by its specific inhibitors significantly increased the therapeutic effect of doxorubicin (DOX) on OS cell lines (MG-63 and HOS). Moreover, miR-24 inhibitors resensitized the doxorubicin-resistant MG-63 cells (MG-63/R) and HOS cells (HOS/R) to DOX...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27618431/microrna-223-increases-the-sensitivity-of-triple-negative-breast-cancer-stem-cells-to-trail-induced-apoptosis-by-targeting-hax-1
#14
Xu Sun, Yongqing Li, Meizhu Zheng, Wenshu Zuo, Wenzhu Zheng
Drug resistance remains a significant challenge in the treatment of triple-negative breast cancer (TNBC). Recent studies have demonstrated that this drug resistance is associated with a group of cells known as cancer stem cells (CSCs), which are believed to determine the sensitivity of tumor cells to cancer treatment. MicroRNAs (miRNAs) are small, non-coding RNAs that play significant roles in normal and cancer cells. MiR-223 reportedly acts as a tumor suppressor in a range of cancers. However, the role of miR-223 in TNBC, especially in triple-negative breast cancer stem cells (TNBCSCs), remains unknown...
2016: PloS One
https://www.readbyqxmd.com/read/27563705/interplay-of-mitochondrial-metabolism-and-micrornas
#15
REVIEW
Julian Geiger, Louise T Dalgaard
Mitochondria are important organelles in cellular metabolism. Several crucial metabolic pathways such as the energy producing electron transport chain or the tricarboxylic acid cycle are hosted inside the mitochondria. The proper function of mitochondria depends on the import of proteins, which are encoded in the nucleus and synthesized in the cytosol. Micro-ribonucleic acids (miRNAs) are short non-coding ribonucleic acid (RNA) molecules with the ability to prevent messenger RNA (mRNA)-translation or to induce the degradation of mRNA-transcripts...
August 25, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27552933/combined-expression-of-mir-34a-and-smac-mediated-by-oncolytic-vaccinia-virus-synergistically-promote-anti-tumor-effects-in-multiple-myeloma
#16
Wen Lei, Shibing Wang, Chunmei Yang, Xianbo Huang, Zhenzhen Chen, Wei He, Jianping Shen, Xinyuan Liu, Wenbin Qian
Despite great progress made in the treatment of multiple myeloma (MM), it is still incurable. Promising phase II clinical results have been reported recently for oncolytic vaccinia virus (OVV) clinic therapeutics. One reason for this has focused on the critical therapeutic importance of the immune response raised by these viruses. However, few studies have performed their applications as an optimal delivery system for therapeutic gene, especially miRNA in MM. In this study, we constructed two novel OVVs (TK deletion) that express anti-tumor genes, miR-34a and Smac, respectively, in MM cell lines and xenograft model...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27542393/microrna-21-lowers-blood-pressure-in-spontaneous-hypertensive-rats-by-upregulating-mitochondrial-translation
#17
Huaping Li, Xiaorong Zhang, Feng Wang, Ling Zhou, Zhongwei Yin, Jiahui Fan, Xiang Nie, Peihua Wang, Xiang-Dong Fu, Chen Chen, Dao Wen Wang
BACKGROUND: Excessive reactive oxygen species generated in mitochondria has been implicated as a causal event in hypertensive cardiomyopathy. Multiple recent studies suggest that microRNAs (miRNAs) are able to translocate to mitochondria to modulate mitochondrial activities, but the medical significance of such a new miRNA function has remained unclear. Here, we characterized spontaneous hypertensive rats (SHRs) in comparison with Wistar rats, finding that micro RNA-21 (miR-21) was dramatically induced in SHRs relative to Wistar rats...
September 6, 2016: Circulation
https://www.readbyqxmd.com/read/27519795/tumor-suppressor-mirna-204-5p-promotes-apoptosis-by-targeting-bcl2-in-prostate-cancer-cells
#18
Yi-Chia Lin, Ji-Fan Lin, Te-Fu Tsai, Kuang-Yu Chou, Hung-En Chen, Thomas I-Sheng Hwang
BACKGROUND: Prostate cancer (PCa) is a leading cause of cancer-related death in men, which emphasizes the need for novel therapeutic approaches. Targeting microRNA (miRNA) has been considered as a therapeutic strategy against cancers. Human miR-204-5p potentially targeting BCL2 has been reported to be downregulated in various cancers. We hypothesized that miR-204-5p overexpression induces cancer cell apoptosis by repressing BCL2 expression. METHODS: A vector harboring mature miR-204-5p was constructed and delivered into human PCa cells...
August 9, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27497958/fis1-depletion-in-osteoarthritis-impairs-chondrocyte-survival-and-peroxisomal-and-lysosomal-function
#19
Dongkyun Kim, Jinsoo Song, Yeonho Kang, Sujung Park, Yong-Il Kim, Seongae Kwak, Dongkwon Lim, Raekil Park, Churl-Hong Chun, Seong-Kyu Choe, Eun-Jung Jin
: Cumulative evidence suggests the importance of organelle homeostasis in regulating metabolic functions in response to various cellular stresses. Particularly, the dynamism and health of the mitochondria-peroxisome network through fission and fusion are essential for cellular function; dysfunctional dynamism underlies the pathogenesis of several degenerative diseases including Parkinson's disease. Here, we investigated the role of Fis1 in cartilage homeostasis and its relevance to osteoarthritis (OA)...
December 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27492459/microrna-target-for-macc1-and-cyr61-to-inhibit-tumor-growth-in-mice-with-colorectal-cancer
#20
Guiqi Wang, Jingfeng Gu, Yingchao Gao
Cysteine-rich protein 61 (CYR61) and metastasis associated in colon cancer (MACC1) protein promoted human colorectal cancer (CRC) cell metastasis and closely related to the patient's prognosis in colorectal cancer. The purpose of this article is to investigate whether CYR61 and MACC1 can serve as dual potential targets for gene therapy of human CRC. In this study, microRNA (miRNA) targeting for both CYR61 and MACC1 was used to investigate the mechanism and therapeutic effects for CRC cells and mice with CRC...
October 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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