Lu Li, Kunlu Zhao, Jian Luo, Jinhong Tian, Fengxin Zheng, Xueman Lin, Zijun Xie, Heyang Jiang, Yongmei Li, Zean Zhao, Ting Wu, Jianxin Pang
Uncontrolled hyperuricemia often leads to the development of hyperuricemic nephropathy (HN), characterized by excessive inflammation and oxidative stress. Piperine, a cinnamic acid alkaloid, possesses various pharmacological activities, such as antioxidant and anti-inflammatory effects. In this study, we intended to investigate the protective effects of piperine on adenine and potassium oxonate-induced HN mice and a uric-acid-induced injury model in renal tubular epithelial cells (mRTECs). We observed that treatment with piperine for 3 weeks significantly reduced serum uric acid levels and reversed kidney function impairment in mice with HN...
March 18, 2024: Journal of Agricultural and Food Chemistry