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Uric acid nephropathy

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https://www.readbyqxmd.com/read/29860221/simvastatin-ameliorates-diabetic-nephropathy-by-attenuating-oxidative-stress-and-apoptosis-in-a-rat-model-of-streptozotocin-induced-type-1-diabetes
#1
Nawal M Al-Rasheed, Nouf M Al-Rasheed, Yieldez A Bassiouni, Iman H Hasan, Maha A Al-Amin, Hanaa N Al-Ajmi, Ayman M Mahmoud
Statins are HMG-CoA reductase inhibitors with lipid-lowering effect and commonly used to reduce cardiovascular risk in diabetic patients. The present study investigates the ameliorative effect of simvastatin (SIM) on diabetic nephropathy in rats, pointing to its anti-apoptotic and anti-oxidative stress efficacies. Diabetes was induced by a single intraperitoneal injection of 55 mg/kg body weight streptozotocin (STZ) and both control and diabetic rats received 10 mg/kg SIM for 90 days. Treatment with SIM diminished the body weight loss, blood glucose and, serum creatinine, urea and uric acid in diabetic rats...
May 31, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29850970/serum-c3-c4-ratio-is-a-novel-predictor-of-renal-prognosis-in-patients-with-iga-nephropathy-a-retrospective-study
#2
Min Pan, QiongXiu Zhou, ShuBei Zheng, XiaoHan You, Duo Li, Ji Zhang, ChaoSheng Chen, FeiFei Xu, ZhanYuan Li, ZhiHong Zhou, JianNa Zhang
IgA nephropathy (IgAN) is an autoimmune disease associated with complement activation. It is unclear whether the ratio of serum C3 and C4 concentrations (C3/C4 ratio) can predict renal outcomes in IgAN patients. A total of 1503 patients diagnosed with IgAN via renal biopsy were recorded in this study. Poor renal outcomes were defined as > 50% decrease in the baseline estimated glomerular filtration rate (eGFR) or development of end-stage renal disease (ESRD) during follow-up. In total, 712 patients meeting the exclusion/inclusion criteria were selected, and the mean follow-up period was 40...
May 30, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29792136/zinc-dependent-histone-deacetylase-inhibitors-in-cancer-therapeutics-recent-update
#3
Panagiotis I Georgianos, Maria Divani, Theodoros Eleftheriadis, Peter R Mertens, Vassilios Liakopoulos
BACKGROUND: Despite optimal management of diabetic kidney disease (DKD) with intensive glycemic control and administration of agents blocking the renin-angiotensin-aldosterone-system, the residual risk for nephropathy progression to end-stage-renal-disease (ESRD) remains high. Sodium-glucose co-transporter type 2 (SGLT-2)-inhibitors represent a newly-introduced anti-diabetic drug class with pleiotropic actions extending above their glucose-lowering efficacy. Herein, we provide an overview of preclinical and clinical-trial evidence supporting a protective effect of SGLT-2 inhibitors on DKD...
May 23, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29761900/fenofibrate-improves-renal-function-by-amelioration-of-nox-4-il-18-and-p53-expression-in-an-experimental-model-of-diabetic-nephropathy
#4
Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebkar
Among several pathological mechanisms involved in diabetic nephropathy, oxidative stress, inflammation, and apoptosis play a prominent role. Fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, has markedly improved oxidative stress and inflammatory responses, but there is no evidence about its effects on interleukin-18 (IL-18), NADPH oxidase type 4 (NOX-4), and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of fenofibrate on improving the underlying mechanisms of diabetic nephropathy...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29736213/taxifolin-attenuates-diabetic-nephropathy-in-streptozotocin-induced-diabetic-rats
#5
Yanling Zhao, Wenwen Huang, Jiali Wang, Yan Chen, Wen Huang, Yonglin Zhu
The current study evaluates the effects of taxifolin (TA) on streptozotocin (STZ)-induced diabetic nephropathy in rats. We performed oral glucose tolerance tests (OGTTs) to determine blood glucose levels. We also measured the following biochemical parameters: uric acid, creatinine, and serum insulin. Kidney pathology was examined by staining sections with hematoxylin-eosin (H&E). The expression of Caveolin-1 and NF-κB was analyzed by qRT-PCR and western blotting. TA significantly reduced the concentrations of blood glucose, uric acid, creatinine, and serum insulin in STZ-induced diabetic rats...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29718866/tacrolimus-decreases-proteinuria-in-patients-with-refractory-iga-nephropathy
#6
Tingyang Hu, Qingquan Liu, Qing Xu, Hui Liu, Wenhui Qiu, Fei Huang, Shijie Zhang, Yongman Lv
In clinical practice, some IgA nephropathy (IgAN) patients show resistance to or are unable to achieve complete remission using steroids and/or immunosuppressants. The current study aimed to assess the efficacy and safety of tacrolimus in the treatment of cases of refractory IgAN.In this retrospective observational study, 34 primary IgAN patients with refractory proteinuria received tacrolimus for at least 12 months. Complete remission, partial remission, and other clinical data were measured at 1, 3, 6, and 12 months after the initiation of treatment...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29710548/diosmin-and-crocin-alleviate-nephropathy-in-metabolic-syndrome-rat-model-effect-on-oxidative-stress-and-low-grade-inflammation
#7
Rania El-Fawal, Hassan M El Fayoumi, Mona F Mahmoud
Nephropathy is a serious complication of metabolic syndrome (MS), a global epidemic disorder. This study was undertaken to investigate the actions of diosmin and crocin, two natural ingredients, on diabetic nephropathy in a rat model of MS and the underlying mechanism(s). Metabolic syndrome was induced by the addition of 10% fructose to drinking water and placing the rats on high-salt diet for 16 weeks. Diosmin and Crocin were orally administrated daily for 10 weeks starting at week 6. At the end of study, arterial blood pressure was non-invasively recorded...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29709468/glycated-hemoglobin-targets-and-glycemic-control-link-with-lipid-uric-acid-and-kidney-profile
#8
Anthony P Sunjaya, Angela F Sunjaya
AIMS: To compare uric acid, lipid, and kidney profile along with management and complications of Indonesian diabetic patients with good and poor glycemic control based on glycated hemoglobin profile. MATERIALS AND METHODS: Data was obtained from medical records of Internal Medicine Clinic in Hermina Podomoro General Hospital for the period January-December 2015. Subjects were grouped into good and poor glycemic control groups based on their glycated hemoglobin (HbA1c) levels...
April 24, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29697385/intensity-of-the-antioxidant-protection-system-and-oxidative-stress-factors-in-patients-with-non-alcoholic-steatohepatitis-depending-on-the-form-of-chronic-kidney-disease
#9
O Khukhlina, A Antoniv, L Kanovska, M Matushchak, V Vivsyannuk
The article presents a theoretical generalization of the research results the intensity of the antioxidant protection system and oxidative stress factors in patients with non-alcoholic steatohepatitis depending on the form of chronic kidney disease. The objective of the article - determining the pathogenetic role of the processes of antioxidant protection system in the development and interconnection mechanisms of non-alcoholic steatohepatitis (NASH) and obesity depending on the form and stage of chronic kidney disease (CKD)...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29682805/protective-effects-of-sarsasapogenin-against-early-stage-of-diabetic-nephropathy-in-rats
#10
Yao-Wu Liu, Yun-Chao Hao, Ya-Jing Chen, Shen-Yuan Yin, Meng-Ya Zhang, Li Kong, Tao-Yun Wang
Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic complications. This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. Diabetic rats were divided into 3 groups treated orally with Sar (0, 20, or 60 mg/kg) and carboxymethylcellulose sodium, whereas normal rats for Sar (0 or 60 mg/kg) and carboxymethylcellulose sodium...
April 23, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29667911/experimental-heat-stress-nephropathy-and-liver-injury-are-improved-by-allopurinol
#11
Carlos A Roncal-Jimenez, Yuka Sato, Tamara Milagres, Ana Andres-Hernando, Gabriela E Garcia, Petter Bjornstad, Jaime Butler-Dawson, Cecilia Sorensen, Lee Newman, Lyndsay Krisher, Magdalena Madero, Jason Glaser, Ramon Garcia-Trabannino, Emmanuel Jarquin-Romero, Zhilin Song, Thomas Jensen, Masanari Kuwabara, Bernardo Rodriguez-Iturbe, Laura-Gabriela Sanchez-Lozada, Miguel A Lanaspa, Richard J Johnson
BACKGROUND: An epidemic of chronic kidney disease (CKD) has been observed in Central America among workers in the sugarcane fields. One hypothesis is that the CKD may be caused by recurrent heat stress and dehydration, and potentially by hyperuricemia. Accordingly, we developed a murine model of kidney injury associated with recurrent heat stress. In the current experiment, we tested whether treatment with allopurinol (a xanthine oxidase inhibitor that reduces serum urate) provides renal protection against recurrent heat stress and dehydration...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29660007/uric-acid-is-not-associated-with-diabetic-nephropathy-and-other-complications-in-type-1-diabetes
#12
Sascha Pilemann-Lyberg, Tine Willum Hansen, Frederik Persson, Simone Theilade, Tarunveer Singh Ahluwalia, Jan Frystyk, Peter Rossing
Background: To examine the association between plasma uric acid (UA) and the presence of diabetic complications including diabetic nephropathy and cardiovascular risk factors in patients with type 1 diabetes. Methods: This study, which is cross-sectional in design, included 676 Caucasian type 1 diabetes patients from the Steno Diabetes Center Copenhagen. Participants with UA within the three lowest sex-specific quartiles were compared with participants with levels in the highest quartile...
April 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29657028/monosodium-urate-crystals-induced-icam-1-expression-and-cell-cell-adhesion-in-renal-mesangial-cells-implications-for-the-pathogenesis-of-gouty-nephropathy
#13
Shue-Fen Luo, Chia-Yin Chin, Ling-Jun Ho, Wen-Yi Tseng, Chang-Fu Kuo, Jenn-Haung Lai
BACKGROUND: Renal disease is prevalent in gouty patients and monosodium urate (MSU) crystal deposition in the kidney can be detected in some gouty nephropathy patients. MSU crystals can induce inflammatory events, we investigated the MSU-induced expression of intercellular adhesion molecule (ICAM)-1 on human renal mesangial cells (HRMCs) and the involved signal transduction mechanisms. METHODS: The HRMCs cell line was purchased from ScienCell Research Laboratories...
January 31, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29652115/analysis-on-influencing-factors-of-abnormal-renal-function-in-elderly-patients-with-type-2-diabetes-mellitus
#14
Tao Chai, Dawei Zhang, Zhongxin Li
BACKGROUND: To investigate the related influencing factors of abnormal renal function in elderly in patients with type 2 diabetes mellitus (T2DM) and their clinical significance. METHODS: The clinical data of elderly T2DM patients hospitalized in Beijing Luhe Hospital from January 2013 to June2016 were retrospectively analyzed. According to their glomerular filtration rate (GFR) levels, these patients were divided into GFR ≥90 mL/min/1.73m2 group (Group A), GFR =60-90 mL/min/1...
April 12, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29626589/red-onion-scales-ameliorated-streptozotocin-induced-diabetes-and-diabetic-nephropathy-in-wistar-rats-in-relation-to-their-metabolite-fingerprint
#15
Tarek Kamal Abouzed, María Del Mar Contreras, Kadry Mohamed Sadek, Moustafa Shukry, Doaa H Abdelhady, Wael Mohamed Gouda, Walied Abdo, Nasr Elsayed Nasr, Reham Hassan Mekky, Antonio Segura-Carretero, Khaled Abdel-Aleim Kahilo, Essam Abdel-Sattar
AIM: The present study was designed to investigate the effect of red onion scales extract (ROS) against diabetic nephropathy, in relation to its metabolic profiling. METHODS: Four groups of male Wistar rats were assigned as follows; 1st untreated group, 2nd group (animals with diabetes) treated with streptozotocin (STZ, 50 mg/kg) IP, 3rd group co-treated with ROS (150 mg/kg + STZ, 50 mg/kg) and 4th group co-treated with ROS by a dose (300 mg/kg + STZ, 50 mg/kg) daily...
June 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29593629/risk-of-microangiopathy-in-patients-with-epilepsy-under-long-term-antiepileptic-drug-therapy
#16
Nai-Ching Chen, Chih-Hsin Chen, Tsu-Kung Lin, Shang-Der Chen, Meng-Han Tsai, Chiung-Chih Chang, Wan-Chen Tsai, Yao-Chung Chuang
Background: Long-term antiepileptic drug (AED) therapy is considered a risk factor of atherosclerosis. Furthermore, the duration of therapy contributes to acceleration of large-vessel atherosclerosis. Therefore, in this study, we tested the hypothesis that long-term AED therapy plays a crucial role in the pathogenesis of microangiopathy in patients with epilepsy. Methods: We recruited 120 patients with epilepsy (age, 18-60 years) and 40 healthy controls. Optical coherence tomography (OCT) was used to measure the central macular thickness and diameters of the retinal artery and vein to evaluate atherosclerotic retinopathy; microalbumin and creatinine levels in urine were assessed to evaluate atherosclerotic nephropathy...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29575259/crocin-improves-renal-function-by-declining-nox-4-il-18-and-p53-expression-levels-in-an-experimental-model-of-diabetic-nephropathy
#17
Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebkar
Oxidative damage, inflammation and apoptosis play significant roles in diabetic nephropathy. Previous studies demonstrated anti-inflammatory and anti-oxidative effects of crocin, but there is no evidence about its effects on IL-18, NOX-4, and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of crocin on improving main mechanisms underlying diabetic nephropathy. Male Wistar rats were randomly divided into four separate groups as normal (C), normal treated (CC), diabetic (D), and diabetic treated (DC) (n = 6)...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29568334/serum-uric-acid-and-renal-function-in-patients-with-type-1-diabetes-a-nationwide-study-in-brazil
#18
Marcela Haas Pizarro, Deborah Conte Santos, Bianca Senger Vasconcelos Barros, Laura Gomes Nunes de Melo, Marilia Brito Gomes
Background: Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the association between levels of serum uric acid and renal function assessed by glomerular filtration rate (GFR) and albuminuria in patients with type 1 diabetes. Methods: This is a multicenter, cross-sectional, observational study with 1686 patients, conducted between August 2011 and August 2014 in 14 public clinics from ten Brazilian cities...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29540159/a-cross-sectional-study-on-the-relationship-between-hematological-data-and-quantitative-morphological-indices-from-kidney-biopsies-in-different-glomerular-diseases
#19
Michelangelo Nigro, Davide Viggiano, Vincenzo Ragone, Tiziana Trabace, Annamaria di Palma, Michele Rossini, Giovambattista Capasso, Loreto Gesualdo, Giuseppe Gigliotti
BACKGROUND: The classical approach to the analysis of kidney biopsies is based on semi-quantitative scores of the amount of sclerosis, inflammatory infiltrate, fibrosis and vascular damage. However, advanced renal lesions may be accompanied by a paucity of clinical features and, conversely, important clinical abnormalities may be accompanied by minimal histopathological changes. The objective of this study is to correlate new, semiautomatic, quantitative features of kidney biopsies (e...
March 14, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29534864/serum-uric-acid-and-progression-of-diabetic-nephropathy-in-type-1-diabetes
#20
S Pilemann-Lyberg, M Lindhardt, Frederik Persson, S Andersen, P Rossing
AIMS: Uric acid (UA) is a risk factor for CKD. We evaluated UA in relation to change in GFR in patients with type 1 diabetes. METHODS: Post hoc analysis of a trial of losartan in diabetic nephropathy, mean follow-up 3 years (IQR 1.5-3.5). UA was measured at baseline. Primary end-point was change in measured GFR. UA was tested in a linear regression model adjusted for known progression factors (gender, HbA1c , systolic blood pressure, cholesterol, baseline GFR and baseline urinary albumin excretion rate (UAER))...
May 2018: Journal of Diabetes and its Complications
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