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Uric acid nephropathy

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https://www.readbyqxmd.com/read/29465872/-acid-uric-key-player-in-a-recently-recognized-devastating-nephropathy-and-in-the-development-of-chronic-kidney-disease
#1
Antoine Humbert, Fabien Stucker
Uric acid has been known since long ago for its implication in gout and in certain kinds of nephrolithiasis. However, its role in models of acute and chronic nephropathies has been the focus of many new developments. The so called Mesoamerican nephropathy is a devastating disease that has caused more than 20'000 deaths in central America these last few years among sugarcane workers. Acid uric could play a key role in its physiopathology. Moreover, acid uric tends to be recognized as an independent factor of development and progression in chronic kidney disease, opening a way for new therapeutic targets...
February 21, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29424910/correlations-between-blood-uric-acid-and-the-incidence-and-progression-of-type-2-diabetes-nephropathy
#2
G-X Li, X-H Jiao, X-B Cheng
OBJECTIVE: To investigate the relationships between blood uric acid (BUA) level and the incidence, progression and deterioration of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: A total of fifty patients with T2DM alone whose glycosylated hemoglobin (HbA1c) were under normal range (4-6.5%) at their admission to our hospital were randomly selected as diabetes mellitus (DM) group. Fifty patients with hyperuricemia alone were randomly selected as hyperuricemia (HUA) group...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29415951/high-fructose-diet-feeding-accelerates-diabetic-nephropathy-in-spontaneously-diabetic-torii-sdt-rats
#3
Kaoru Toyoda, Yusuke Suzuki, Kyotaka Muta, Taku Masuyama, Kochi Kakimoto, Akio Kobayashi, Toshiyuki Shoda, Shoichiro Sugai
Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple carbohydrate that is present in fruits and honey and is used as a sweetener because of its sweet taste. Fructose has been reported to have the potential to progress diabetes and DN in humans even though fructose itself does not increase postprandial plasma glucose levels. In this study, we investigated the effects of high fructose intake on the kidney of the Spontaneously Diabetic Torii (SDT) rats which have renal lesions similar to those in DN patients and compared these with the effects in normal SD rats...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29415664/gender-related-differences-in-clinicopathological-characteristics-and-renal-outcomes-of-chinese-patients-with-iga-nephropathy
#4
Wei Deng, Xiaojun Tan, Qian Zhou, Zhen Ai, Wenting Liu, Wei Chen, Xueqing Yu, Qiongqiong Yang
BACKGROUND: The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN. METHODS: This was a single-centre retrospective study. Patients were divided into two groups according to gender. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as the doubling of baseline serum creatinine and end-stage renal disease (ESRD) (estimated glomerular filtration rate < 15 mL/min/1...
February 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29412122/sodium-glucose-cotransporter-2-inhibitors-nephroprotective-impact-on-diabetic-kidney-disease
#5
Konstantinos Stavropoulos, Konstantinos Imprialos, Nikiforos Stavropoulos, Sofia Bouloukou, Georgios Kerpiniotis, Kyriakos Dimitriadis, Constantinos Tsioufis, Michael Doumas
BACKGROUND: Diabetic nephropathy is a crucial microvascular complication of diabetes mellitus that is associated with elevated cardiovascular risk. SGLT-2 inhibitors are a new class of hypoglycemic drugs that positively affect several risk factors of cardiorenal damage. OBJECTIVES: To review and critically discuss available data on the association of SGLT-2 inhibitors treatment with kidney function, progress of diabetic kidney disease, and renal related outcomes, as well to unveil potential mechanisms of action that mediate such effects...
February 6, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29393137/uric-acid-and-diabetic-nephropathy-risk
#6
Michael Mauer, Alessandro Doria
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) in the western world. Current treatment methods, with better control of glycemia and blood pressure, including renin-angiotensin system blockade (RASB), appear to have slowed the DN progression rate but have not substantially decreased the annual incidence of new DN ESRD cases. Thus, new treatment targets are needed. SUMMARY: Higher levels of serum uric acid (UA) are associated with increased risk of the clinical manifestations of DN in persons with types 1 and 2 diabetes...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29393097/uric-acid-the-lower-the-better
#7
Gianni Bellomo, Antonio Selvi
BACKGROUND: Uric acid (UA) is still considered a risk factor, or even a causative agent, for chronic kidney disease (CKD); however, a few, important, clinical questions remain unanswered; in particular: when and whether urate-lowering therapy should be commenced in subjects with asymptomatic hyperuricemia and/or monosodium urate crystals deposition? What is the most appropriate UA target to be achieved and how long does it need to be maintained? How does treatment need be adjusted in patients with chronic kidney disease? SUMMARY: The observational and intervention studies available do not fully answer such questions, and a treatment to target trial is required...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29393086/uric-acid-the-unknown-uremic-toxin
#8
Alejandro Treviño-Becerra
This review brings together concepts of uric acid metabolism affecting renal parenchyma and its function and the current therapies to reduce hyperuricemia (HyU) and avoid renal disease progression. High uric acid plays an important role in several chronic diseases including kidney diseases such as lithiasis, gout nephropathy, and preeclampsia. In the last 30 years, it has been shown that reducing HyU with low protein and low purine diets in addition to allopurinol creates physiopathological conditions that produce a slight increase in the glomerular filtration rate (GFR)...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29372470/uric-acid-lowering-and-renoprotective-effects-of-topiroxostat-a-selective-xanthine-oxidoreductase-inhibitor-in-patients-with-diabetic-nephropathy-and-hyperuricemia-a-randomized-double-blind-placebo-controlled-parallel-group-study-upward-study
#9
Takashi Wada, Tatsuo Hosoya, Daisuke Honda, Ryusuke Sakamoto, Kazutaka Narita, Tomomitsu Sasaki, Daisuke Okui, Kenjiro Kimura
BACKGROUND: Hyperuricemia is supposed to be an independent risk factor for kidney dysfunction in diabetic patients. We attempted to examine the uric acid-lowering effect and the renoprotective effect of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia in this pilot study. METHODS: The study design was randomized, double-blind, placebo-controlled, parallel-group study. A total of 65 patients with hyperuricemia and diabetic nephropathy with microalbuminuria were enrolled and assigned to either the topiroxostat group or the placebo group...
January 25, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29371869/allopurinol-prophylactic-therapy-and-the-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-coronary-angiography-a-prospective-randomized-controlled-trial
#10
Leili Iranirad, Mohammad Saleh Sadeghi, Ahmadreza Bagheri, Kobra Doostali, Samieh Norouzi, Seyed Fakhreddin Hejazi, Hossein Saghafi, Sakineh Roshani-Mobaraki
BACKGROUND: Contrast-induced nephropathy (CIN) is considered to be a possibly severe complication of radiography and thus, remains to be the main cause of acute kidney injury (AKI) for inpatients. A clinical trial was executed to measure the preventive effect of allopurinol against CIN in high-risk patients undertaking coronary angiography. METHODS: Through randomized controlled trial, 140 patients with at minimum two risk factors of CIN, undertaking coronary angiography, were randomly allocated to the allopurinol (n = 70) or control group (n = 70)...
September 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29359786/uric-acid-upregulates-the-adiponectin%C3%A2-adiponectin-receptor%C3%A2-1-pathway-in-renal-proximal-tubule-epithelial-cells
#11
Qingmei Yang, Chensheng Fu, Jing Xiao, Zhibin Ye
Adiponectin (APN) is a protein hormone that is primarily derived from adipocytes. It can also be secreted by renal cells. Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated. The present study investigated the expression of APN and AdipoR1 in cultured PTECs that were exposed to SUA through immunofluorescence and western blot analysis...
December 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29340054/febuxostat-attenuates-er-stress-mediated-kidney-injury-in-a-rat-model-of-hyperuricemic-nephropathy
#12
Li He, Ying Fan, Wenzhen Xiao, Teng Chen, Jiejun Wen, Yang Dong, Yiyun Wang, Shiqi Li, Rui Xue, Liyang Zheng, John Cijiang He, Niansong Wang
Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephropathy. We first found the expression of RTN1A and ER stress markers was significantly increased in kidney biopsies of hyperuricemia patients with kidney injury. In a rat model of hyperuricemic nephropathy (HN) established by oral administration of a mixture of adenine and potassium oxonate, increased expression of RTN1A and ER stress was shown in tubular and interstitial compartment of rat kidneys...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29315768/the-effect-of-uric-acid-lowering-treatment-on-albuminuria-and-renal-function-in-type-1-diabetes-a-randomized-clinical-trial
#13
S Pilemann-Lyberg, F Persson, J Frystyk, P Rossing
Significant improvements have been made in the management of Type 1 diabetes over the last three decades [1]. We wanted to examine if uric acid lowering with allopurinol changes the urinary albumin excretion rate (UAER) or 51 Cr EDTA GFR in people with Type 1 diabetes and diabetic nephropathy. This article is protected by copyright. All rights reserved.
January 7, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29305119/weicao-capsule-ameliorates-renal-injury-through-increasing-autophagy-and-nlrp3-degradation-in-uan-rats
#14
Jiacai Hu, Hao Wu, Daochun Wang, Zhijie Yang, Lihua Zhuang, Na Yang, Junjun Dong
Uric acid nephropathy (UAN) is one of the most common metabolic diseases and leads to kidney damage. This study aimed to evaluate the effect of Weicao capsule on renal injury of UAN rats and to examine whether the mechanism was associated with induction of autophagy and degradation of nucleotide binding oligomerization domain (Nod)-like receptor (NLR) protein 3 (NLRP3) inflammasome. Sixty Sprague-Dawley rats were randomly allocated into 6 groups: Control, Model, Allopurinol, and Weicao (0.55/1.1/2.2 g/kg) group...
January 2, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29295969/the-saudi-diabetic-kidney-disease-study-saudi-dkd-clinical-characteristics-and-biochemical-parameters
#15
Khalid Al-Rubeaan, Khalid Siddiqui, Mohammed Alghonaim, Amira M Youssef, Dhekra AlNaqeb
BACKGROUND: Saudi Arabia is facing an epidemic of type 2 diabetes that is complicated by a high rate of chronic complications such as kidney disease, which have a major impact on the healthcare system and economy. The Saudi diabetic kidney disease (SAUDI-DKD) study was launched to understand the implications of chronic diabetic kidney disease . OBJECTIVES: Examine the hematological, biochemical and metabolic parameters of the selected cohorts to look for biomarkers of diabetic nephropathy...
January 3, 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29201206/combined-treatment-of-diabetic-nephropathy-with-alprostadil-and-calcium-dobesilate
#16
Lili Qin, Wenjun Qin, Jianfei Wang, Lin Lin
This study investigated the effects of alprostadil combined with calcium dobesilate on the treatment of diabetic nephropathy. We recruited 80 patients with diabetic nephropathy, who were randomly divided into experimental (n=40) and control (n=40) groups. Patients received high-quality low-protein diabetic diet intervention and subcutaneous injection of insulin to adjust blood glucose, combined with antihypertensive, antiplatelet drugs, and other comprehensive treatments. The control group received alprostadil and the experimental group received alprostadil combined with calcium dobesilate...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29104632/fucoidan-elevates-surface-organic-cation-transporter-2-expression-via-upregulation-of-protein-kinase-a-in-uric-acid-nephropathy
#17
Xinlin Wu, Miansheng Yan, Taoli Liu, Jiantang Liao, Jianqing Zhang, Shuqing Chen, Wei Deng, Shijun Zhang, Baoguo Sun, Houming Zhou, Bin Ke
Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polysaccharide component of brown algae, on UAN and to elucidate the underlying molecular mechanism. A rat model of UAN was induced by adenine treatment, and rats were then randomly assigned to control, model or fucoidan treatment groups. Hematoxylin and eosin staining of the kidney tissues of rats with UAN was subjected to conventional morphological evaluation...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29089475/melatonin-and-or-rowatinex-attenuate-streptozotocin-induced-diabetic-renal-injury-in-rats
#18
Tarek K Motawi, Samia A Ahmed, Manal A Hamed, Shohda A El-Maraghy, Wessam M Aziz
The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin (50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen (BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), total antioxidant capacity (TAC), kidney injury molecule-1 (KIM-1), heat shock protein-70 (HSP-70), caspase-3, transforming growth factor β1 (TGFβ1), DNA degradation by the comet assay and total protein contents...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29045935/emodinol-ameliorates-urate-nephropathy-by-regulating-renal-organic-ion-transporters-and-inhibiting-immune-inflammatory-responses-in-rats
#19
Hui Wu, Mengze Zhou, Guo Lu, Zhonglin Yang, Hui Ji, Qinghua Hu
Emodinol, 1β, 3β, 23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our Research Group, was identified with apparent uricosuric and nephroprotective effects in hyperuricemia mice in our previous study. This study aimed to investigate the renal protective effect of emodinol in urate nephropathy rats. Rats were orally administrated by combined adenine and ethambutol to induce urate nephropathy. Emodinol at various doses were administered intragastrically to urate nephropathy rats daily...
October 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29017152/high-uric-acid-induced-epithelial-mesenchymal-transition-of-renal-tubular-epithelial-cells-via-the-tlr4-nf-kb-signaling-pathway
#20
Huifang Liu, Jiachuan Xiong, Ting He, Tangli Xiao, Yan Li, Yanlin Yu, Yinghui Huang, Xinli Xu, Yunjian Huang, Jingbo Zhang, Bo Zhang, Jinghong Zhao
BACKGROUND: Hyperuricemia is an independent risk factor for causing chronic kidney disease and contributes to kidney fibrosis. After urate crystals get deposited in the kidney, they can cause hyperuricemia nephropathy, leading to glomerular hypertrophy and renal tubular interstitial fibrosis. Recent data showed that uric acid (UA) could induce epithelial mesenchymal transition (EMT) of renal tubular cells, in which NRLP3 inflammatory pathway was involved. However, whether TLR4/NF-κB signaling pathway is also involved in EMT of renal tubular cells induced by UA is not clear...
2017: American Journal of Nephrology
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