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Yury M Borisov, Iryna A Kryshchuk, Helen S Gaiduchenko, Elena V Cherepanova, Svetlana V Zadyra, Elena S Levenkova, Dmitriy V Lukashov, Victor N Orlov
The common shrews, Sorex araneus Linnaeus, 1758, inhabiting the territory of Belarus, are characterized by a significant variation in the frequency of Robertsonian (Rb) translocations. The frequency clines for translocations specific of three chromosome races: the West Dvina (gm, hk, ip, no, qr), Kiev (g/m, hi, k/o, n, p, q, r), and Białowieża (g/r, hn, ik, m/p, o, q) have already been studied in this territory. In this communication we report new data on polymorphic populations with Rb metacentrics specific of the Neroosa race (go, hi, kr, mn, p/q) in south-eastern Belarus, analyse the distribution of karyotypes in southern and central Belarus and draw particular attention to the fixation of the acrocentric variants of chromosomes in this area...
2017: Comparative Cytogenetics
Viktor Juhász, Tibor Hornyik, Attila Benák, Norbert Nagy, Zoltan Husti, Robert Pap, László Sághy, László Virág, András Varró, István Baczkó
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of morbidity and mortality. Traditional antiarrhythmic agents used for restoration of sinus rhythm have limited efficacy in long-term AF and they may possess ventricular proarrhythmic adverse effects, especially in patients with structural heart disease. The acetylcholin receptor-activated potassium channel (I<sub>K,ACh</sub>) represents an atrial-selective target for future AF management. We investigated the effects of the I<sub>K,ACh</sub> blocker tertiapin-Q (TQ), a derivative of the honeybee toxin tertiapin, on chronic atrial tachypacing induced AF in conscious dogs, without the influence of anesthetics that modulate a number of cardiac ion channels...
September 11, 2017: Canadian Journal of Physiology and Pharmacology
Raju U Patil, Rajesh T Anegundi, Kumar R Gujjar, K R Indushekar
Pemphigus is a chronic mucocutaneous disease that initially manifests in the form of intraoral blisters which spread to other mucous membrane and skin. This study describes an unusual case of chronic generalized childhood pemphigus disease in an 11-year-old girl, who presented with multiple vesicles all over her body. Such a condition is seen more often in older people rather than children. It is crucial for dental professionals to be familiar with the diagnosis of bullous skin diseases in children and adolescents, especially in its initial stages in order to prevent the serious consequences and morbidity...
April 2017: International Journal of Clinical Pediatric Dentistry
Deepa Bullappa, Manjunath P Puranik, K R Sowmya, T Nagarathnamma
INTRODUCTION: Early childhood caries (ECC) is a virulent form of dental caries that can destroy the primary dentition of toddlers and preschool children. The aim was to determine the relationship of feeding methods and oral Streptococcus mutans count in 3- to 5-year-old children with ECC. MATERIALS AND METHODS: A cross-sectional study was conducted in children aged 3 to 5 years. Participating mothers were interviewed regarding child's demographic profile, educational level and socioeconomic status of parents, past medical and dental history of the mother and child, child's feeding habits, and dietary habits and oral hygiene practices of mother and child...
April 2017: International Journal of Clinical Pediatric Dentistry
K Mitev, P Cassette, I Tartès, S Georgiev, I Dimitrova, D Pressyanov
This work presents the results of an experimental study of the Makrofol(®) N and Makrofol(®) DE polycarbonate foils absorption properties of (85)Kr and (131m)Xe. The diffusion lengths of (85)Kr and (131m)Xe in both types of foils are determined. The partition coefficients of (85)Kr from air and water and that of (131m)Xe from air in Makrofol(®) N are determined. The partition coefficients of (85)Kr from water and (131m)Xe from air in Makrofol(®) DE are also determined. The parameters are determined for T = 22°C and allow for the full characterization of sorption and desorption of (85)Kr and (131m)Xe in the foils at this temperature...
July 14, 2017: Applied Radiation and Isotopes
Kunichika Tsumoto, Yasutaka Kurata, Kazuharu Furutani, Yoshihisa Kurachi
Some cardiovascular and non-cardiovascular drugs frequently cause excessive prolongation of the cardiac action potential (AP) and lead to the development of early afterdepolarisations (EADs), which trigger lethal ventricular arrhythmias. Combining computer simulations in APs with numerical calculations based on dynamical system theory, we investigated stability changes of APs observed in a paced human ventricular myocyte model by decreasing and/or increasing the rapid (I Kr) and slow (I Ks) components of delayed rectifying K(+) current...
September 7, 2017: Scientific Reports
C H Lee, E Eskin, B Han
Motivation: Meta-analysis is essential to combine the results of genome-wide association studies (GWASs). Recent large-scale meta-analyses have combined studies of different ethnicities, environments and even studies of different related phenotypes. These differences between studies can manifest as effect size heterogeneity. We previously developed a modified random effects model (RE2) that can achieve higher power to detect heterogeneous effects than the commonly used fixed effects model (FE)...
July 15, 2017: Bioinformatics
Jungsul Lee, Chulhee Choi
Motivation: Expression profile of normal tissue is primary source to find genes showing aberrant expression pattern specific in matched cancer tissue, but sample number of normal control in public gene expression repositories is disproportionally small compared to cancer and scattered in several datasets. Results: We built oncopression by integrating several datasets into one large dataset for comprehensive analysis about 25 types of human cancers including 20 640 cancer samples and 6801 normal control profiles...
July 1, 2017: Bioinformatics
Urszula Szczepaniak, Robert Kolos, Marcin Gronowski, Michele Chevalier, Jean-Claude Guillemin, Michal Turowski, Thomas Gage Custer, Claudine Crepin
HC9N is a molecule of astrochemical interest. In this study, it was produced in cryogenic Ar and Kr matrices from UV-photolyzed diacetylene/cyanodiacetylene mixtures. Its strong phosphorescence was discovered and served for the identification of the compound. Vibrationally-resolved phosphorescence excitation spectra gave insight into excited singlet electronic states. Two electronic systems were observed: around 26 000 - 34 000 cm(-1) and 35 000 - 50 000 cm(-1). Energies of the second excited singlet and the lowest triplet state were derived from analysis of these systems...
September 5, 2017: Journal of Physical Chemistry. A
Abhishek Bhattacharya, Pranjal Biswas, Puranjoy Kar, Piya Roychoudhury, Sankar Basu, Souradipta Ganguly, Sanjay Ghosh, Koustubh Panda, Ruma Pal, Anjan Kr Dasgupta
Nitric oxide (NO) acts as a signalling molecule that has direct and indirect regulatory roles in various functional processes in biology, though in plant kingdom its role is relatively unexplored. One reason for this is the fact that sensing of NO is always challenging. There are very few probes that can classify the different NO species. The present paper proposes a simple but straightforward way for sensing different NO species using chlorophyll, the source of inspiration being hemoglobin that serves as NO sink in mammalian systems...
September 8, 2017: Analytica Chimica Acta
C R Seon, J H Hong, I Song, J Jang, H Y Lee, Y H An, B S Kim, T M Jeon, J S Park, W Choe, H G Lee, S Pak, M S Cheon, J H Choi, H S Kim, W Biel, P Bernascolle, R Barnsley
The ITER vacuum ultra-violet (VUV) core survey spectrometer has been designed as a 5-channel spectral system so that the high spectral resolving power of 200-500 could be achieved in the wavelength range of 2.4-160 nm. To verify the design of the ITER VUV core survey spectrometer, a two-channel prototype spectrometer was developed. As a subsequent step of the prototype test, the prototype VUV spectrometer has been operated at KSTAR since the 2012 experimental campaign. From impurity injection experiments in the years 2015 and 2016, strong emission lines, such as Kr xxv 15...
August 2017: Review of Scientific Instruments
Kawaljit Singh Kaura, Manoj Kumar, Ashok Kr Sokhal, Ashok Kr Gupta, Bimalesh Purkait, Durgesh Saini, Satyanarayan Sankhwar
OBJECTIVE: Giant hydronephrosis (GH) is a rare entity in both developed and developing countries with less than 500 cases reported in the literature. Delayed diagnosis and management of GH, can result in long-term complications like hypertension, rupture of the kidney, renal failure and malignant change. We aim to highlight the importance of this often neglected entity and build a consensus for its early diagnosis and management. MATERIAL AND METHODS: Patients with GH were thoroughly worked up, managed and followed up between June 2013 and December 2015 and epidemiologic, radiological, perioperative and follow-up data was recorded...
September 2017: Turkish Journal of Urology
Lijuan Zhang, Yuebin Zhang, Jie Cheng, Lei Wang, Xingya Wang, Meng Zhang, Yi Gao, Jun Hu, Xuehua Zhang, Junhong Lü, Guohui Li, Renzhong Tai, Haiping Fang
Biologically inert gases play important roles in the biological functionality of proteins. However, researchers lack a full understanding of the effects of these gases since they are very chemically stable only weakly absorbed by biological tissues. By combining X-ray fluorescence, particle sizing and molecular dynamics (MD) simulations, this work shows that the aggregation of these inert gases near the hydrophobic active cavity of pepsin should lead to protein deactivation. Micro X-ray fluorescence spectra show that a pepsin solution can contain a high concentration of Xe or Kr after gassing, and that the gas concentrations decrease quickly with degassing time...
August 31, 2017: Scientific Reports
Zhengguo Huang, Yuying Li, Xiaohong Wang
Although HNgCCX (Ng = Kr and Xe; X = F and Cl) have been identified in cryogenic matrices, similar Br and I analogues have not been prepared so far. In this paper, the nature of HNgCCX (Ng = Kr and Xe; X = F, Cl, Br and I) have been investigated by ab initio methods. The main characteristic absorption peak of HNgCCX is the v H-Ng, which decreases as X varies from F to I. Moreover, the H-Xe bond is stronger than the H-Kr bond. The v C≡C and v C-X exhibit red- and blue-shift characters, respectively, especially the C-X bond is abnormal blue-shift halogen bond...
August 31, 2017: Scientific Reports
Lianping Zhao, Ying Wang, Yanbin Jia, Shuming Zhong, Yao Sun, Zhifeng Zhou, Zhongping Zhang, Li Huang
OBJECTIVE: Bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes. However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD. METHODS: Thirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions...
July 2017: Psychiatry Investigation
K G Veinot, S A Dewji, M M Hiller, K F Eckerman, C E Easterly
External dose coefficients for environmental exposure scenarios are often computed using assumption on infinite or semi-infinite radiation sources. For example, in the case of a person standing on contaminated ground, the source is assumed to be distributed at a given depth (or between various depths) and extending outwards to an essentially infinite distance. In the case of exposure to contaminated air, the person is modeled as standing within a cloud of infinite, or semi-infinite, source distribution. However, these scenarios do not mimic common workplace environments where scatter off walls and ceilings may significantly alter the energy spectrum and dose coefficients...
August 24, 2017: Radiation and Environmental Biophysics
Hans Kr Flaatten
No abstract text is available yet for this article.
August 21, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Baozhu Yang, Shuang Huang, Jianhao Wang
A series of cyclometalated platinum(ii) complexes have been investigated with the TDDFT method. These complexes have similar structures but distinct phosphorescence quantum yields. Theoretical calculations were carried out to explain the differences in quantum yields from the conjugation effect of the cyclometalated ligand, molecular rigidity and ligand-field strength of the monodentate ligand. The radiative decay rate constants (kr) have been discussed with the oscillator strength (fn), the strength of the spin-orbit coupling (SOC) interaction between the lowest energy triplet excited state (T1) and singlet excited states (Sn), and the energy gaps between E(T1) and E(Sn)...
August 22, 2017: Physical Chemistry Chemical Physics: PCCP
Stephanie R Reading, Kimberly R Porter, Jeffrey M Slezak, Teresa N Harrison, Joy S Gelfond, Gary W Chien, Steven J Jacobsen
INTRODUCTION: Many men diagnosed with prostate cancer are concerned with how the disease and its course of treatment could affect their health-related quality of life (HRQOL). To aid in the decision-making process on a course of treatment and to better understand how these treatments can affect HRQOL, knowledge of pretreatment HRQOL is essential. AIMS: To assess the racial and ethnic variations in HRQOL scores in men newly diagnosed with prostate cancer before electing a course of treatment...
August 18, 2017: Sexual Medicine
Hyung-Gwan Lee, So-Ra Ko, Jun-Woo Lee, Chang Soo Lee, Chi-Yong Ahn, Hee-Mock Oh, Long Jin
Two Gram-stain-negative, aerobic, non-motile, non-spore-forming and rod-shaped bacteria, designated strains T2T and T5, were isolated from a culture of Microcystis from Daejeon, Republic of Korea. Comparative 16S rRNA gene sequence studies placed the new isolates in the class Alphaproteobacteria and, notably, most closely related to Blastomonasaquatica PE 4-5T, Blastomonas natatoria DSM 3183T and Blastomonas ursincola KR-99T showing 99.4 %, 98.2 % and 97.9 % 16S rRNA gene sequence similarities, respectively...
August 2017: International Journal of Systematic and Evolutionary Microbiology
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