Read by QxMD icon Read


Hye-Young Jung, Sangseob Leem, Sungyoung Lee, Taesung Park
BACKGROUND: Gene-gene interaction (GGI) is one of the most popular approaches for finding the missing heritability of common complex traits in genetic association studies. The multifactor dimensionality reduction (MDR) method has been widely studied for detecting GGIs. In order to identify the best interaction model associated with disease susceptibility, MDR compares all possible genotype combinations in terms of their predictability of disease status from a simple binary high(H) and low(L) risk classification...
September 29, 2016: Computational Biology and Chemistry
Hemant Gujar, Subba Reddy Palli
To begin studies on reproduction in common bed bug, Cimex lectularius, we identified three genes coding for vitellogenin (Vg, a protein required for the reproductive success of insects) and studied their hormonal regulation. RNA interference studied showed that expression of Vg3 gene in the adult females is a prerequisite for successful completion of embryogenesis in the eggs laid by them. Juvenile hormone (JH) receptor, Methoprene-tolerant (Met), steroid receptor coactivator (SRC) and GATAa but not ecdysone receptor (EcR) or its partner, ultraspiracle (USP) are required for expression of Vg genes...
October 20, 2016: Scientific Reports
Sunwon Lee, Donghyeon Kim, Kyubum Lee, Jaehoon Choi, Seongsoon Kim, Minji Jeon, Sangrak Lim, Donghee Choi, Sunkyu Kim, Aik-Choon Tan, Jaewoo Kang
As the volume of publications rapidly increases, searching for relevant information from the literature becomes more challenging. To complement standard search engines such as PubMed, it is desirable to have an advanced search tool that directly returns relevant biomedical entities such as targets, drugs, and mutations rather than a long list of articles. Some existing tools submit a query to PubMed and process retrieved abstracts to extract information at query time, resulting in a slow response time and limited coverage of only a fraction of the PubMed corpus...
2016: PloS One
Makoto Kawaguchi, Noboru Hara, Vladimir Bilim, Hiroshi Koike, Mituko Suzuki, Tae-Sun Kim, Nan Gao, Yu Dong, Sheng Zhang, Yuji Fujinawa, Osamu Yamamoto, Hiromi Ito, Yoshihiko Tomita, Yuchi Naruse, Akira Sakamaki, Yoko Ishii, Koichi Tsuneyama, Masaaki Inoue, Johbu Itoh, Masanori Yasuda, Nobuo Sakata, Cha-Gyun Jung, Satoshi Kanazawa, Hiroyasu Akatsu, Hiroshi Minato, Takayuki Nojima, Kiyofumi Asai, Yutaka Miura
BACKGROUND: Pathological stage and grade have limited ability to predict the outcomes of superficial urothelial bladder carcinoma at initial transurethral resection (TUR). AT-motif binding factor 1 (ATBF1) is a tumor suppressive transcription factor that is normally localized to the nucleus but has been detected in the cytoplasm in several cancers. Here, we examined the diagnostic value of the intracellular localization of ATBF1 as a marker for the identification of high risk urothelial bladder carcinoma...
October 18, 2016: BMC Cancer
Abhishek Srivastava, Vijender Panduga, Ramanatha Saralaya, Prabhakar Kr, Shahul Hameed, Suresh Solapure, Vinayak Hosagrahara
During the course of metabolic profiling of lead Compound 1, glutathione (GSH) conjugates were detected in rat bile, suggesting the formation of reactive intermediate precursor(s). This was confirmed by the identification of GSH and N-acetylcysteine (NAC) conjugates in microsomal incubations. It was proposed that bioactivation of Compound 1 occurs via the formation of a di-iminoquinone reactive intermediate through the involvement of the C-2 and C-5 nitrogens of the pyrimidine core. To further investigate this hypothesis, structural analogues with modifications at the C-5 nitrogen were studied for metabolic activation in human liver microsomes supplemented with GSH/NAC...
October 18, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Sunil Kr Verma
A 62-year-old male was undergoing treatment of NHL with bone marrow involvement with thrombocytopenia. After 15min of starting of IV infusion of rituximab, he started having severe retrosternal chest pain, diagnosed as acute ST elevation inferior wall MI. Patient was pre-loaded with dual anti platelets. Coronary angiogram showed 100% occlusion of proximal RCA. Thrombosuction of this culprit RCA revealed underlying 90% stenosis. After that, PCI with balloon angioplasty of RCA was done. The procedure was terminated in the view of successful balloon angioplasty with good TIMI flow...
September 2016: Indian Heart Journal
Shenli Zhang, Maria Perez-Page, Kelly Guan, Erick Yu, Joseph W Tringe, Ricardo H R Castro, Roland Faller, Pieter Stroeve
Molecular Dynamics (MD) and Monte Carlo (MC) simulations were applied together for the first time to reveal the porous structure transformation mechanisms of mesoporous silica MCM-41 subjected to temperatures up to 2885 K. Silica was experimentally characterized to inform the models and enable prediction of changes in gas adsorption/separation properties. MD simulations suggest that the pore closure process is activated by a collective diffusion of matrix atoms into the porous region, accompanied by bond reformation at the surface...
October 17, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Bernard Lavielle, Bertrand Thomas, Eric Gilabert, Gregory Canchel, Denis Horlait, Sylvain Topin, Fabien Pointurier, Christophe Moulin
A double focusing sector field mass filter used in Nier-Johnson geometry has been built in order to perform Kr isotope enrichment for (81) Kr and (85) Kr isotopes. The principle consists in implanting Kr(+) ions accelerated at 7 keV in Al foils after separation using the magnetic sector. A specific ion source has been designed capable of generating high Kr(+) ion beams (>0.5 μA) to transfer into the collecting Al foils in 3 to 5 h significant fractions of large Kr samples (10(15) to 10(16) atoms) initially introduced in the instrument...
October 2016: Journal of Mass Spectrometry: JMS
Santhosh Ks, Raveendra Kr, Prakash Bc
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Debasish Barik, Raveendra Kr, Prakash Bc
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Ashish Kr Sharma, Nutan Agarwal, Manish Sharma, Nisha Awasthi, Akanksha Mishra
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Wenjie Yu, Xing Liu, Bing Xu, Xiaopeng Xing, Xuefeng Wang
The novel noble-gas complexes NgBeSO2 (Ng=Ne, Ar, Kr, Xe) have been prepared in the laser-evaporated beryllium atom reactions with SO2 in low-temperature matrices. Doped with heavier noble gas, the guest (Ar, Kr, Xe) atom can substitute neon to form more stable complex. Infrared spectroscopy and theoretical calculations are used to confirm the band assignment. The dissociation energies are calculated at 0.9, 4.0, 4.7, and 6.0 kcal/mol for NeBeSO2, ArBeSO2, KrBeSO2, and XeBeSO2, respectively, at the CCSD(T) level...
October 11, 2016: Journal of Physical Chemistry. A
Leena Mandal, Samit Majumder, Sasankasekhar Mohanta
The work in the present investigation reports the syntheses, crystal structures, ESI-MS (positive) and steady state and time resolved photophysical properties of a tetraaminodiphenol macrocyclic ligand H2L (saturated analogue of a tetraiminodiphenol macrocycle obtained on 2 + 2 condensation of 4-ethyl-2,6-diformylphenol and 2,2-dimethyl-1,3-diaminopropane) and its three dinuclear d(10) metal ion (Zn(II), Cd(II) and Hg(II)) complexes having compositions [ZnLCl2]·2CH3OH (1), [CdL(μ-H2O)(H2O)2](NO3)2·4H2O (2) and [HgLCl2] (3)...
October 10, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Ufuk Çorumlu, Cem Kopuz, Mehmet Tevfik Demir, Mennan Ece Pirzirenli
Elongation or hyperplasia of coronoid process of mandible is rare condition characterized by abnormal bone development which cause malocclusion and the limited mouth opening. In this study, in an Anatolian skull, a case of bilateral elongation of mandibular coronoid process was presented. Levandoski panographic analysis was performed on the panoramic radiographie to determine the hyperplasia of the coronoid process. The right condylar process was exactly hyperplastic. The measurements of Kr-Go/Cd-Go were 95...
September 2016: Anatomy & Cell Biology
Subrata Pal, Sajeeb Mondal, Palash Kr Mondal, Gargi Raychaudhuri, Rajashree Pradhan, Suparna Banerjee
Calcified broad ligament leiomyoma is a rare benign lesion in postmenopausal age group. It causes diagnostic confusion with solid calcified adnexal mass and large bladder calculi at the pelvic region. Clinical and radiological diagnoses were confirmed by histopathology of the hysterectomy specimen. We hereby present a case of heavily calcified broad ligament fibroid in a postmenopausal woman.
July 2016: Journal of Mid-life Health
Marcella Araújo Manfredi, Alyne Alexandrino Antunes, Larissa de Oliveira Passos Jesus, Maria Aparecida Juliano, Luiz Juliano, Wagner Alves de Souza Judice
Kex2 is a Ca(2+)-dependent serine protease from S. cerevisiae. Characterization of the substrate specificity of Kex2 is of particular interest because this protease serves as the prototype of a large family of eukaryotic subtilisin-related proprotein-processing proteases that cleave sites consisting of pairs or clusters of basic residues. Our goal was to study the prime region subsite S' of Kex2 because previous studies have only taken into account non-prime sites using AMC substrates but not the specificity of prime sites identified through structural modeling or predicted cleavage sites...
October 5, 2016: Biochimie
Wenting Zhang, Yafei Luo, Yanyan Xu, Wenqian Li, Wei Shen
Aromatic sulfonyl groups have attracted increasing interest due to unique electronic features. In this article, a series of Ir(III) complexes bearing fluorinated phenylsulfonyl were calculated via density functional theory (DFT) and time-dependent density functional theory (TDDFT) methods. To further explore phosphorescence efficiencies, the factors which determine the radiative decay rate constant kr and the non-radiative decay rate constant knr were computed. As demonstrated by the results, complex 4, introducing fluorinated phenylsulfonyl into 5-position of phenyl rings for all three C^N ligands, is supposed to have the highest phosphorescence efficiencies with larger kr and the smallest knr among these complexes...
October 7, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Erik R Mohlhenrich, Rachel Lockridge Mueller
Salamanders have the largest nuclear genomes among tetrapods and, excepting lungfishes, among vertebrates as a whole. Lynch and Conery (2003) have proposed the mutational-hazard hypothesis to explain variation in genome size and complexity. Under this hypothesis, non-coding DNA imposes a selective cost by increasing the target for degenerative mutations, i.e. the mutational hazard. Expansion of non-coding DNA, and thus genome size, is driven by increased levels of genetic drift and/or decreased mutation rates; the former determines the efficiency with which purifying selection can remove excess DNA, while the latter determines the level of mutational hazard...
October 7, 2016: Evolution; International Journal of Organic Evolution
Bashir Zikria, Nima Hafezi-Nejad, Frank W Roemer, Ali Guermazi, Shadpour Demehri
Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding knee trauma. Materials and Methods The HIPAA-compliant protocol was approved by the institutional review boards of the participating centers. Written informed consent was obtained from all participants. Subjects who underwent meniscal surgery with a preceding knee trauma at baseline (n = 564) and those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796)...
October 3, 2016: Radiology
Jangwoo Lee, Seung Gu Shin, Jinmo Ahn, Gyuseong Han, Kwanghyun Hwang, Woong Kim, Seokhwan Hwang
Seven white rot fungal species were tested for growth as mycelia using swine wastewater (SW), an agro-waste with tremendous environmental footprint, as the sole nutrient source. The SW contained high concentrations of carbon and nitrogen components, which could support nutritional requirements for mycelial growth. Out of the seven species, Pleurotus ostreatus and Hericium erinaceus were successfully cultivated on the SW medium using solid-state fermentation. Response surface methodology was employed to determine the combination of pH, temperature (T), and substrate concentration (C) that maximizes mycelial growth rate (Kr) for the two species...
September 30, 2016: Applied Biochemistry and Biotechnology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"