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https://www.readbyqxmd.com/read/28225654/germicidal-efficacy-and-mammalian-skin-safety-of-222-nm-uv-light
#1
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D Lowy, David M Owens, David J Brenner
We have previously shown that 207-nm ultraviolet (UV) light has similar antimicrobial properties as typical germicidal UV light (254 nm), but without inducing mammalian skin damage. The biophysical rationale is based on the limited penetration distance of 207-nm light in biological samples (e.g. stratum corneum) compared with that of 254-nm light. Here we extended our previous studies to 222-nm light and tested the hypothesis that there exists a narrow wavelength window in the far-UVC region, from around 200-222 nm, which is significantly harmful to bacteria, but without damaging cells in tissues...
February 22, 2017: Radiation Research
https://www.readbyqxmd.com/read/28211202/role-of-modular-polyketide-synthases-in-the-production-of-polyether-ladder-compounds-in-ciguatoxin-producing-gambierdiscus-polynesiensis-and-g-excentricus-dinophyceae
#2
Gurjeet S Kohli, Katrina Campbell, Uwe John, Kirsty F Smith, Santiago Fraga, Lesley L Rhodes, Shauna A Murray
Gambierdiscus, a benthic dinoflagellate, produces ciguatoxins that cause the human illness Ciguatera. Ciguatoxins are polyether ladder compounds that have a polyketide origin, indicating that polyketide synthases (PKS) are involved in their production. We sequenced transcriptomes of G. excentricus and G. polynesiensis and found 264 contigs encoding single domain ketoacyl synthases (KS; G. excentricus: 106, G. polynesiensis: 143) and ketoreductases (KR; G. excentricus: 7, G. polynesiensis: 8) with sequence similarity to type I PKSs, as reported in other dinoflagellates...
February 17, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28198846/femtosecond-two-photon-laser-induced-fluorescence-of-krypton-for-high-speed-flow-imaging
#3
Yejun Wang, Cade Capps, Waruna D Kulatilaka
Ultrashort-pulse (femtosecond-duration) two-photon laser-induced fluorescence (fs-TPLIF) of an inert gas tracer krypton (Kr) is investigated. A detailed spectroscopic study of fluorescence channels followed by the 5p<sup>'</sup>←←4p excitation of Kr at 204.1 nm is reported. The experimental line positions in the 750-840 nm emission region agree well with the NIST Atomic Spectra Database. The present work provides an accurate listing of relative line strengths in this spectral region. In the range of laser pulse energies investigated, a quadratic dependence was observed between the Kr-TPLIF signal and the laser pulse energy...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28186521/diverging-effects-of-isotopic-fractionation-upon-molecular-diffusion-of-noble-gases-in-water-mechanistic-insights-through-ab-initio-molecular-dynamics-simulations
#4
Halua Pinto de Magalhães, Matthias S Brennwald, Rolf Kipfer
Atmospheric noble gases are routinely used as natural tracers to analyze gas transfer processes in aquatic systems. Their isotopic ratios can be employed to discriminate between different physical transport mechanisms by comparison to the unfractionated atmospheric isotope composition. In many applications of aquatic systems molecular diffusion was thought to cause a mass dependent fractionation of noble gases and their isotopes according to the square root ratio of their masses. However, recent experiments focusing on isotopic fractionation within a single element challenged this broadly accepted assumption...
February 10, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28184254/npcare-database-of-natural-products-and-fractional-extracts-for-cancer-regulation
#5
Hwanho Choi, Sun Young Cho, Ho Jeong Pak, Youngsoo Kim, Jung-Yun Choi, Yoon Jae Lee, Byung Hee Gong, Yeon Seok Kang, Taehoon Han, Geunbae Choi, Yeeun Cho, Soomin Lee, Dekwoo Ryoo, Hwangseo Park
BACKGROUND: Natural products have increasingly attracted much attention as a valuable resource for the development of anticancer medicines due to the structural novelty and good bioavailability. This necessitates a comprehensive database for the natural products and the fractional extracts whose anticancer activities have been verified. DESCRIPTION: NPCARE (http://silver.sejong.ac.kr/npcare) is a publicly accessible online database of natural products and fractional extracts for cancer regulation...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28173642/a-novel-urotensin-ii-receptor-antagonist-kr-36996-inhibits-smooth-muscle-proliferation-through-erk-ros-pathway
#6
Tae-Ho Kim, Dong Gil Lee, Young-Ae Kim, Byung Ho Lee, Kyu Yang Yi, Yi-Sook Jung
Urotensin II (UII) is a mitogenic and hypertrophic agent that can induce the proliferation of vascular cells. UII inhibition has been considered as beneficial strategy for atherosclerosis and restenosis. However, currently there is no therapeutics clinically available for atherosclerosis or restenosis. In this study, we evaluated the effects of a newly synthesized UII receptor (UT) antagonist, KR-36996, on the proliferation of SMCs in vitro and neointima formation in vivo in comparison with GSK-1440115, a known potent UT antagonist...
February 6, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28164620/comparison-of-b-cell-activating-factor-expression-in-neutrophils-in-patients-with-potentially-malignant-disorders-and-patients-with-cancer-in-the-same-site
#7
Ewa Jab O Ska, Bo Ena S Odczyk, Natalia Wawrusiewicz-Kurylonek, Dorota Dziemia Czyk-Pakie A, Marzena Garley, Wioletta Ratajczak-Wrona, Jan Borys, Adam Kr Towski
BACKGROUND: B-cell activating factor (BAFF) belongs to the TNF superfamily of proteins, which influences the life span of normal and malignant cells. It has been demonstrated that there is an overexpression of BAFF in peripheral blood neutrophils and mononuclear cells in patients with oral squamous cell carcinoma (OSCC), suggesting a tumor-promoting activity of those cells. Taking into consideration that numerous OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs), involving e...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164251/state-dependent-block-of-voltage-gated-sodium-channels-by-the-casein-kinase-1-inhibitor-ic261
#8
Karl J Föhr, Uwe Knippschild, Anna Herkommer, Michael Fauler, Christian Peifer, Michael Georgieff, Oliver Adolph
Background and Purpose IC261 (3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one) has previously been introduced as an isoform specific inhibitor of casein kinase 1 (CK1) causing cell cycle arrest or cell death of established tumor cell lines. However, it is reasonable to assume that not all antitumor activities of IC261 are mediated by the inhibition of CK1. Meanwhile there is growing evidence that functional voltage-gated sodium channels are also implicated in the progression of tumors as their blockage suppresses tumor migration and invasion of different tumor cell lines...
February 6, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28163023/a-novel-urotensin-ii-receptor-antagonist-kr-36996-improved-cardiac-function-and-attenuated-cardiac-hypertrophy-in-experimental-heart-failure
#9
Kwang-Seok Oh, Jeong Hyun Lee, Kyu Yang Yi, Chae Jo Lim, Byung Kil Park, Ho Won Seo, Byung Ho Lee
Urotensin II and its receptor are thought to be involved in various cardiovascular diseases such as heart failure, pulmonary hypertension and atherosclerosis. Since the regulation of the urotensin II/urotensin II receptor offers a great potential for therapeutic strategies related to the treatment of cardiovascular diseases, the study of selective and potent antagonists for urotensin II receptor is more fascinating. This study was designed to determine the potential therapeutic effects of a newly developed novel urotensin II receptor antagonist, N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)piperidin-4-yl)benzo[b]thiophene-3-carboxamide (KR-36996), in experimental models of heart failure...
February 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28157306/mechanism-and-stereochemistry-of-polyketide-chain-elongation-and-methyl-group-epimerization-in-polyether-biosynthesis
#10
Xinqiang Xie, Ashish Garg, Chaitan Khosla, David E Cane
The polyketide synthases responsible for the biosynthesis of the polyether antibiotics nanchangmycin (1) and salinomycin (4) harbor a number of redox-inactive ketoreductase (KR(0)) domains that are implicated in the generation of C2-epimerized (2S)-2-methyl-3-ketoacyl-ACP intermediates. Evidence that the natural substrate for the polyether KR(0) domains is, as predicted, a (2R)-2-methyl-3-ketoacyl-ACP intermediate, came from a newly developed coupled ketosynthase (KS)-ketoreductase (KR) assay that established that the decarboxylative condensation of methylmalonyl-CoA with S-propionyl-N-acetylcysteamine catalyzed by the Nan[KS1][AT1] didomain from module 1 of the nanchangmycin synthase generates exclusively the corresponding (2R)-2-methyl-3-ketopentanoyl-ACP (7a) product...
February 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28157282/chalcogenide-aerogels-as-sorbents-for-noble-gases-xe-kr
#11
Kota S Subrahmanyam, Ioannis Spanopoulos, Jaehun Chun, Brian J Riley, Praveen K Thallapally, Pantelis N Trikalitis, Mercouri G Kanatzidis
High-surface-area molybdenum sulfide (MoSx) and antimony sulfide (SbSx) chalcogels were studied for Xe/Kr gas separation. The intrinsic soft Lewis basic character of the chalcogel framework is a unique property among the large family of porous materials and lends itself to a potential new approach toward the selective separation of Xe over Kr. Among these chalcogels, MoSx shows the highest Xe and Kr uptake, reaching 0.69 mmol g(-1) (1.05 mmol cm(-3)) and 0.28 mmol g(-1) (0.42 mmol cm(-3)) respectively, at 273 K and 1 bar...
February 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28155707/prioritizing-biological-pathways-by-recognizing-context-in-time-series-gene-expression-data
#12
Jusang Lee, Kyuri Jo, Sunwon Lee, Jaewoo Kang, Sun Kim
BACKGROUND: The primary goal of pathway analysis using transcriptome data is to find significantly perturbed pathways. However, pathway analysis is not always successful in identifying pathways that are truly relevant to the context under study. A major reason for this difficulty is that a single gene is involved in multiple pathways. In the KEGG pathway database, there are 146 genes, each of which is involved in more than 20 pathways. Thus activation of even a single gene will result in activation of many pathways...
December 23, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28151440/equilibrium-and-kinetics-study-on-removal-of-arsenate-ions-from-aqueous-solution-by-ctab-tio2-and-starch-ctab-tio2-nanoparticles-a-comparative-study
#13
Pankaj Gogoi, Debasish Dutta, Tarun Kr Maji
We present a comparative study on the efficacy of TiO2 nanoparticles for arsenate ion removal after modification with CTAB (N-cetyl-N,N,N-trimethyl ammonium bromide) followed by coating with starch biopolymer. The prepared nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), thermogravimetry, scanning electron microscopy (SEM) and electron dispersive X-ray analysis (EDX). The removal efficiency was studied as a function of contact time, material dose and initial As(V) concentration...
February 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28147604/large-region-acoustic-source-mapping-using-a-movable-array-and-sparse-covariance-fitting
#14
Shengkui Zhao, Cagdas Tuna, Thi Ngoc Tho Nguyen, Douglas L Jones
Large-region acoustic source mapping is important for city-scale noise monitoring. Approaches using a single-position measurement scheme to scan large regions using small arrays cannot provide clean acoustic source maps, while deploying large arrays spanning the entire region of interest is prohibitively expensive. A multiple-position measurement scheme is applied to scan large regions at multiple spatial positions using a movable array of small size. Based on the multiple-position measurement scheme, a sparse-constrained multiple-position vectorized covariance matrix fitting approach is presented...
January 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28143871/role-of-host-microrna-hsa-mir-139-3p-in-hpv-16-induced-carcinomas
#15
Malay Kr Sannigrahi, Rajni Sharma, Varinder Singh, Naresh K Panda, Vidya Rattan, Madhu Khullar
PURPOSE: Human papillomavirus 16 (HPV-16) is important risk factor in Head and Neck Cancer (HNC). Studies suggest that microRNAs play an important role in cancer, however, their role in HPV mediated oncogenesis remains largely unknown. We investigated the role of microRNAs with HPV-16 as putative target in HPV-16 mediated cancers. EXPERIMENTAL DESIGN: Using in-silico tools, we identified microRNAs with putative binding sequences on HPV-16 mRNAs. Hsa-miR-139-3p was identified as best candidate miRNA by luciferase reporter assay and was found to be significantly down-regulated in HPV-16 positive tissues and cell lines...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28139308/simple-method-for-obtaining-the-optimal-laryngoscopic-view-in-children-a-prospective-observational-study
#16
Eun-Hee Kim, Sang-Hwan Ji, In-Kyung Song, Ji-Hyun Lee, Jin-Tae Kim, Hee-Soo Kim
BACKGROUND: Head and neck positioning has an important effect on laryngeal visualization during laryngoscopy. For small children and infants, a head-flat position is traditionally assumed; however, during laryngoscopy, the optimal head position may result in a superior laryngeal view in certain patients. METHODS: We investigated whether the alignment of the external auditory meatus and the sternal notch with a pillow with an individualized height is associated with improved laryngeal visualization during direct laryngoscopy in pediatric patients...
January 24, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28134238/charge-transfer-to-ground-state-ions-produces-free-electrons
#17
D You, H Fukuzawa, Y Sakakibara, T Takanashi, Y Ito, G G Maliyar, K Motomura, K Nagaya, T Nishiyama, K Asa, Y Sato, N Saito, M Oura, M Schöffler, G Kastirke, U Hergenhahn, V Stumpf, K Gokhberg, A I Kuleff, L S Cederbaum, K Ueda
Inner-shell ionization of an isolated atom typically leads to Auger decay. In an environment, for example, a liquid or a van der Waals bonded system, this process will be modified, and becomes part of a complex cascade of relaxation steps. Understanding these steps is important, as they determine the production of slow electrons and singly charged radicals, the most abundant products in radiation chemistry. In this communication, we present experimental evidence for a so-far unobserved, but potentially very important step in such relaxation cascades: Multiply charged ionic states after Auger decay may partially be neutralized by electron transfer, simultaneously evoking the creation of a low-energy free electron (electron transfer-mediated decay)...
January 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28131607/effectiveness-of-purified-methylene-blue-in-an-experimental-model-of-mycobacterium-ulcerans-infection
#18
Roger B D Tian, Shady Asmar, Claude Napez, Hubert Lépidi, Michel Drancourt
Mycobacterium ulcerans is responsible for Buruli ulcer, characterised by extensive, disabling ulcers. Standard treatment combining rifampicin and streptomycin exposes patients to toxicity and daily painful injections. In this study, the in vitro susceptibilities of 3 M. ulcerans strains, 1 Mycobacterium marinum strain and 18 strains representative of eleven other Mycobacterium species and subspecies to methylene blue were determined. Whilst growth of M. ulcerans was inhibited by 0.0125 g/L methylene blue, growth of all other tested strains was not inhibited by 1 g/L methylene blue...
January 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28129750/disarticle-a-web-server-for-svm-based-discrimination-of-articles-on-traditional-medicine
#19
Sang-Kyun Kim, SeJin Nam, SangHyun Kim
BACKGROUND: Much research has been done in Northeast Asia to show the efficacy of traditional medicine. While MEDLINE contains many biomedical articles including those on traditional medicine, it does not categorize those articles by specific research area. The aim of this study was to provide a method that searches for articles only on traditional medicine in Northeast Asia, including traditional Chinese medicine, from among the articles in MEDLINE. RESULTS: This research established an SVM-based classifier model to identify articles on traditional medicine...
January 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28125359/the-spanish-version-of-the-alberta-infant-motor-scale-validity-and-reliability-analysis
#20
Erica Morales-Monforte, Caridad Bagur-Calafat, Neus Suc-Lerin, Montserrat Fornaguera-Martí, Engracia Cazorla-Sánchez, Montserrat Girabent-Farrés
OBJECTIVES: Validity and reliability of the cross-cultural adaptive translation of the Alberta Infant Motor Scale (AIMS), to monitor gross motor development in infants from 0 to 18 months of age, were evaluated. METHODS: A cross-cultural translation was used to generate a Spanish version of the AIMS. Fifty infants at risk or with diagnosis of motor delay, 0-18 months of age, participated in this study. Two independent physical therapists scored infants on the AIMS...
February 2017: Developmental Neurorehabilitation
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