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Péter P Nánási, János Magyar, András Varró, Balázs Ördög
Beat-to-beat variability of cardiac action potential duration (short term variability, SV) is a common feature of various cardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, the underlying mechanisms are not fully understood at present. The magnitude of SV is basically determined by the intensity of cell-to-cell coupling in multicellular preparations and by the duration of the action potential (APD). To compensate for the APD-dependent nature of SV, the concept of relative SV (RSV) has been introduced by normalizing the changes of SV to the concomitant changes in APD...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
Eun Jung Park, Young Tak Yoon, Chong Kun Hong, Young Rock Ha, Jung Hwan Ahn
BACKGROUND: This study evaluated the efficacy of a teaching method using simulated B-lines of hand ultrasound with a wet foam dressing material. METHODS: This prospective, randomized, noninferiority study was conducted on emergency medical technician students without any relevant training in ultrasound. Following a lecture including simulated (SG) or real video clips (RG) of B-lines, a posttest was conducted and a retention test was performed after 2 months. The test consisted of questions about B-lines in 40 randomly mixed video clips (20 simulated and 20 real videos) with 4 answer scores (R-1 [the correct answer score for the real video clips] vs S-1 [the correct answer score for the simulated video clips] in the posttest, R-2 [the correct answer score for the real video clips] vs S-2 [the correct answer score for the simulated video clips] in the retention test)...
July 2017: Medicine (Baltimore)
Hung-Yuan Lin, Hsin-Yang Chen, Han Bor Fam, Ya-Jung Chuang, Ronald Yeoh, Pi-Jung Lin
PURPOSE: To assess the corneal keratometric values obtained using the VERION image-guided surgery system and other devices. METHODS: This study evaluated the right eyes of 115 cataract patients before intraocular lens (IOL) implantation through consecutive tests using 5 devices: VERION Reference Unit, Placido-based corneal topography (OPD-Scan III), monochromatic light-emitting diodes (LenStar LS900 and AL-Scan), and rotary prism technology (auto kerato-refractometer KR-8800)...
2017: Clinical Ophthalmology
Piya Adhikari, Paulami Pal, Anup Kr Das, Subhabrata Ray, Arpita Bhattacharjee, Bhaskar Mazumder
Lipid-drug conjugates (LDC), which may also be addressed as lipoidal prodrug, have the therapeutic actives chemically bound to a lipid moiety like fatty acids or phospholipids. Fabricated in nano-size, lipid-drug conjugate forms another breed of lipid nanoparticles. LDCs are prepared in order to increase the drug loading and hence prevent leakage of a highly polar drug from a lipophilic matrix. In turn, it assists to achieve active targeting of therapeutics with reduced side effect by altering the pharmacokinetic profile of the drug...
July 16, 2017: International Journal of Pharmaceutics
Karthika J Kadassery, Suman Kr Dey, Alan E Friedman, David C Lacy
The formation of metal-oxygen clusters is an important chemical transformation in biology and catalysis. For example, the biosynthesis of the oxygen-evolving complex in the enzyme photosystem II is a complicated stepwise process that assembles a catalytically active cluster. Herein we describe the role that carbonato ligands have in the formation of the known tetrameric complex [Mn(CO)3(μ3-OH)]4 (1). Complex 1 is synthesized in one step via the treatment of Mn2(CO)10 with excess Me3NO·2H2O. Alternatively, when anhydrous Me3NO is used, an OH-free synthetic intermediate (2) with carbonato ligands is produced...
July 19, 2017: Inorganic Chemistry
Debabrata Dhara, Thangavel Vijayakanth, Milan Kr Barman, Khevath Praveen Kumar Naik, Nicolas Chrysochos, Cem B Yildiz, Ramamoorthy Boomishankar, Carola Schulzke, Vadapalli Chandrasekhar, Anukul Jana
A facile, straightforward synthesis of N-heterocyclic carbene (NHC)-stabilized 1-hydrosilaimine starting from a silicon(iv)-precursor is reported. It has been employed for the addition of an O-H bond of water under ambient conditions without any additional catalyst.
July 27, 2017: Chemical Communications: Chem Comm
Soo Heon Kwak, Jeesoo Chae, Seongmin Choi, Min Jung Kim, Murim Choi, Jong-Hee Chae, Eun-Hae Cho, Tai Ju Hwang, Se Song Jang, Jong-Il Kim, Kyong Soo Park, Yung-Jue Bang
Ethnically specific data on genetic variation are crucial for understanding human biology and for clinical interpretation of variant pathogenicity. We analyzed data obtained by deep sequencing 1303 Korean whole exomes; the data were generated by three independent whole exome sequencing projects (named the KOEX study). The primary focus of this study was to comprehensively analyze the variant statistics, investigate secondary findings that may have clinical actionability, and identify loci that should be cautiously interpreted for pathogenicity...
July 14, 2017: Experimental & Molecular Medicine
Yan Li, Zhenzhen Zhang, Wint Wint Phoo, Ying Ru Loh, Weiling Wang, Shuang Liu, Ming Wei Chen, Alvin W Hung, Thomas H Keller, Dahai Luo, CongBao Kang
The NS2B-NS3 viral protease is an attractive drug target against Zika virus (ZIKV) due to its importance in viral replication and maturation. Here we report the crystal structure of protease in complex with a dipeptide inhibitor, Acyl-KR-aldehyde (compound 1). The aldehyde moiety forms a covalent bond with the catalytic Ser(135) of NS3. The Arg and Lys residues in the inhibitor occupy the S1 and S2 sites of the protease, respectively. Nuclear magnetic resonance studies demonstrate that the complex is in the closed conformation in solution...
June 23, 2017: Structure
O Connan, D Hébert, L Solier, D Maro, G Pellerin, C Voiseux, M Lamotte, P Laguionie
In-air tritium measurements were conducted around the AREVA NC La Hague reprocessing plant, as well as on other sites that are not impacted by the nuclear industry in northwest of France. The results indicate that the dominant tritium form around the AREVA site is HT (86%). HT and HTO levels are lower than 5 and 1 Bq. m(-3) for hourly samples taken in the plume. No tritiated organic molecules (TOM) were detected. 26 measurement campaigns were performed and links were established between near-field (85)Kr, HT and HTO activities...
July 6, 2017: Journal of Environmental Radioactivity
Vidhyadevi Tangaraj, Jean-Marc Janot, Maguy Jaber, Mikhael Bechelany, Sebastien Balme
In the present study, the adsorption capacities of two intercalated smectites, CTAB-saponite and CTAB-montmorillonite with a cationic surfactant, were investigated with three fluorescent dyes namely Rhodamine 640 perchlorate rhodamine (Rho), sulforhodamine B (SR) and Kiton red 620 (KR). The adsorption isotherms fit well with the non-linear Langmuir isotherm model and the maximum adsorption capacities of all the composites are determined. The photophysical properties such as anisotropy and fluorescence lifetime of all the fluorescent dyes over the clay materials are determined...
October 2017: Chemosphere
Jiye Kim, Kyong Mi Jun, Joung Sug Kim, Songhwa Chae, Yoon-Mok Pahk, Tae-Ho Lee, Soo-In Sohn, Soo In Lee, Myung-Ho Lim, Chang-Kug Kim, Yoonkang Hur, Baek Hie Nahm, Yeon-Ki Kim
Accumulated microarray data are used for assessing gene function by providing statistical values for co-expressed genes; however, only a limited number of Web tools are available for analyzing the co-expression of genes of Brassica rapa. We have developed a Web tool called RapaNet (, which is based on a data set of 143 B rapa microarrays compiled from various organs and at different developmental stages during exposure to biotic or abiotic stress. RapaNet visualizes correlated gene expression information via correlational networks and phylogenetic trees using Pearson correlation coefficient (r)...
2017: Evolutionary Bioinformatics Online
Patrik Pollak, Florian Weigend
Segmented contracted Gaussian basis sets optimized at one-electron exact two-component (X2C) level - including a finite size model for the nucleus - are presented for elements up to Rn. These basis sets are counterparts for relativistic all-electron calculations to the Karlsruhe "def2" basis sets for non-relativistic (H-Kr) or effective core potential based (Rb-Rn) treatments. For maximum consistency, the bases presented here were obtained from the latter by modification and re-optimization. Additionally we present extensions for self-consistent two-component calculations, required for the splitting of inner shells by spin-orbit coupling, and auxiliary basis sets for fitting the Coulomb part of the Fock matrix...
July 5, 2017: Journal of Chemical Theory and Computation
Biswajit Mishra, Guangshun Wang
Infections on implanted medical devices are a challenging problem, especially when bacteria form difficult-to-treat biofilms. Antimicrobial peptides are considered to be a solution due to their potency against antibiotic-resistant superbugs. Previously, the authors' laboratory demonstrated the prevention of staphylococcal biofilm formation in an animal catheter model by injecting merecidin (formerly known as 17BIPHE2), a peptide engineered based on the only human cathelicidin. This study documents an alternative solution via covalent immobilization of FK-16, amino acid sequence FKRIVQRIKDFLRNLV-amide, which corresponds to the major antimicrobial region (residues 17-32) of LL-37...
July 4, 2017: Biofouling
Ha Yong Kim, Yong Han Cha, Young Sub Chun, Hyuck Soo Shin
BACKGROUND: The purpose of study was to analyze correlations between bony torsions measured by Staheli's rotation profile, computed tomography (CT) torsional study, and gait analysis in patients with cerebral palsy (CP). MATERIALS & METHOD: The study group comprised of 26 children with CP (spastic diplegia, Gross Motor Function Classification System (GMFCS) 1-2, mean age 12.6 years) with torsional deformities. All subjects were assessed by examining: 1) rotational profile [internal rotation (IR) and external rotation (ER)], 2) CT torsional profile [femoral anteversion (FAV) and tibial torsion (TT)], and 3) gait analysis [mean hip rotation (HR) and mean knee rotation (KR)]...
June 22, 2017: Gait & Posture
M Brouard, J Lawlor, G McCrudden, T Perkins, S A Seamons, P Stevenson, H Chadwick, F J Aoiz
Zeeman quantum beat spectroscopy has been used to determine the thermal (300 K) rate constants for electronic quenching, rotational energy transfer, and collisional depolarization of OH(A(2)Σ(+)) by H2. Cross sections for both the collisional disorientation and collisional disalignment of the angular momentum in the OH(A(2)Σ(+)) radical are reported. The experimental results for OH(A(2)Σ(+)) + H2 are compared to previous work on the OH(A(2)Σ(+)) + He and Ar systems. Further comparisons are also made to the OH(A(2)Σ(+)) + Kr system, which has been shown to display significant non-adiabatic dynamics...
June 28, 2017: Journal of Chemical Physics
F Flavigny, P Doornenbal, A Obertelli, J-P Delaroche, M Girod, J Libert, T R Rodriguez, G Authelet, H Baba, D Calvet, F Château, S Chen, A Corsi, A Delbart, J-M Gheller, A Giganon, A Gillibert, V Lapoux, T Motobayashi, M Niikura, N Paul, J-Y Roussé, H Sakurai, C Santamaria, D Steppenbeck, R Taniuchi, T Uesaka, T Ando, T Arici, A Blazhev, F Browne, A Bruce, R Carroll, L X Chung, M L Cortés, M Dewald, B Ding, S Franchoo, M Górska, A Gottardo, A Jungclaus, J Lee, M Lettmann, B D Linh, J Liu, Z Liu, C Lizarazo, S Momiyama, K Moschner, S Nagamine, N Nakatsuka, C Nita, C R Nobs, L Olivier, R Orlandi, Z Patel, Zs Podolyák, M Rudigier, T Saito, C Shand, P A Söderström, I Stefan, V Vaquero, V Werner, K Wimmer, Z Xu
We report on the first γ-ray spectroscopy of low-lying states in neutron-rich ^{98,100}Kr isotopes obtained from ^{99,101}Rb(p,2p) reactions at ∼220  MeV/nucleon. A reduction of the 2_{1}^{+} state energies beyond N=60 demonstrates a significant increase of deformation, shifted in neutron number compared to the sharper transition observed in strontium and zirconium isotopes. State-of-the-art beyond-mean-field calculations using the Gogny D1S interaction predict level energies in good agreement with experimental results...
June 16, 2017: Physical Review Letters
Birthe Trautz, Hannah Wiedemann, Christian L Uumlchtenborg, Virginia Pierini, Jan Kranich, B Aumlrbel Glass, Hans-Georg Kr Aumlusslich, Thomas Brocker, Massimo Pizzato, Alessia Ruggieri, Britta Br Uumlgger, Oliver T Fackler
The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV-1 particles and is counteracted by the viral pathogenesis factor Nef. However, the molecular mechanism by which SERINC5 restricts HIV-1 particle infectivity is still unclear. Since SERINC proteins have been suggested to facilitate the incorporation of serine during the biosynthesis of membrane lipids and because lipid composition of HIV particles is a major determinant of the particles infectious potential, we tested whether SERINC5-mediated restriction of HIV particle infectivity involves alterations of membrane lipid composition...
June 28, 2017: Journal of Biological Chemistry
Ho Young Suk, Mu-Yeong Lee, Han-Gyu Bae, Seo-Jin Lee, Nikolay Poyarkov, Hang Lee, Mi-Sook Min
Onychodactylus koreanus, a hynobiid salamander species endemic to the Korean Peninsula, can be regarded as a strict ecological specialist, probably vulnerable to anthropogenic environmental modifications and climate change. We used mitochondrial cytochrome b gene to analyze the genetic diversity and phylogenetic structure of O. koreanus from 19 populations collected in an attempt to cover its major distribution within South Korea. A total of 76 haplotypes of O. koreanus obtained in our analyses could be subdivided into three phylogenetic clades, KR, NE and SE...
June 28, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
Rishi Ram Ghimire, Rajib Nath, Rajesh Kr Neogy, A K Raychaudhuri
We report a new strategy for ligand-free attachment of plasmonic Au nanoparticles on the surface of a ZnO nanowire to make high-performance broadband photodetectors using a pulsed laser ablation technique in a liquid medium. The photoresponse of the ZnO-based photodetector is enhanced and the photodetection limit is broadened from UV to visible, which can be controlled by varying the concentration of Au nanoparticles attached to the ZnO surface. This Au nanoparticle concentration can be tuned by varying the number of laser pulses used in the ablation process...
June 28, 2017: Nanotechnology
Pierre Asselin, Alexey Potapov, Andrew C Turner, Vincent Boudon, Laurent Bruel, Marc-André Gaveau, Michel Mons
Taking advantage of a versatile set-up, combining pulsed pin hole or slit nozzle supersonic expansion with an external cavity quantum cascade laser, the rovibrational absorption spectrum of the SF6 dimer in the ν3 mode region has been revisited at high resolution under various experimental conditions in SF6:He mixtures. Two new rotationally resolved spectral bands have been identified in the range of the parallel band of the dimer spectrum in addition to that previously reported. Among these three spectral features, two of them are assigned to conformations of the dimer (noted #1 and #2), clearly distinguished from their different S-S interatomic distances, i...
June 22, 2017: Physical Chemistry Chemical Physics: PCCP
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