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https://www.readbyqxmd.com/read/27915018/design-and-surface-immobilization-of-short-anti-biofilm-peptides
#1
Biswajit Mishra, Tamara Lushnikova, Radha M Golla, Xiuqing Wang, Guangshun Wang
: Short antimicrobial peptides are essential to keep us healthy and their lasting potency can inspire the design of new types of antibiotics. This study reports the design of a family of eight-residue tryptophan-rich peptides (TetraF2W) obtained by converting the four phenylalanines in temporin-SHf to tryptophans. The temporin-SHf template was identified from the antimicrobial peptide database (http://aps.unmc.edu/AP). Remarkably, the double arginine variant (TetraF2W-RR) was more effective in killing methicillin-resistant Staphylococcus aureus (MRSA) USA300, but less cytotoxic to human skin HaCat and kidney HEK293 cells, than the lysine-containing dibasic combinations (KR, RK and KK)...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27913885/effect-of-sensor-location-on-regional-cerebral-oxygen-saturation-measured-by-invos-5100-in-on-pump-cardiac-surgery
#2
Ah-Reum Cho, Jae-Young Kwon, Choongrak Kim, Jung-Min Hong, Christine Kang
PURPOSE: Near-infrared spectroscopy sensors often cannot be attached at the commercially recommended locations because combined use of neurological monitoring systems is common during on-pump cardiac surgery. The primary purpose of this study was to compare the incidence of regional cerebral oxygen desaturation and regional cerebral oxygen saturation values detected using near-infrared spectroscopy between the upper and lower forehead during on-pump cardiac surgery. METHODS: A prospective observational study was conducted with 25 adult patients scheduled for elective on-pump cardiac surgery...
December 2, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27911043/a-cyclic-alkyl-amino-carbene-as-two-atom-%C3%AF-chromophore-leading-to-the-first-phosphorescent-linear-cu-i-complexes
#3
Markus Gernert, Ulrich Müller, Martin Haehnel, Jens Pflaum, Andreas Steffen
A series of linear and trigonal copper(I) complexes bearing a cyclic alkyl(amino)carbene (CAAC) ligand show surprising photophysical properties when compared to their corresponding N-heterocyclic carbene (NHC) complexes. Whereas the linear NHC complexes [CuX(NHC)] are nearly non-emissive, [CuX(CAAC)] (X = Cl, Br, I) and [Cu(CAAC)2]PF6 show very bright emission from their triplet excited states in the blue to green region displaying quantum yields of up to 65% in the solid state, although the π-acceptor comprises only the carbene C and N atoms with no other π conjugation...
December 2, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27910394/determination-of-relative-krypton-fission-product-yields-from-14-mev-neutron-induced-fission-of-238-u-at-the-national-ignition-facility
#4
E R Edwards, W S Cassata, C A Velsko, C B Yeamans, D A Shaughnessy
Precisely-known fission yield distributions are needed to determine a fissioning isotope and the incident neutron energy in nuclear security applications. 14 MeV neutrons from DT fusion at the National Ignition Facility induce fission in depleted uranium contained in the target assembly hohlraum. The fission yields of Kr isotopes (85m, 87, 88, and 89) are measured relative to the cumulative yield of (88)Kr and compared to previously tabulated values. The results from this experiment and England and Rider are in agreement, except for the (85m)Kr/(88)Kr ratio, which may be the result of incorrect nuclear data...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910374/development-of-a-high-resolution-x-ray-spectrometer-for-the-national-ignition-facility-nif
#5
K W Hill, M Bitter, L Delgado-Aparicio, P C Efthimion, R Ellis, L Gao, J Maddox, N A Pablant, M B Schneider, H Chen, S Ayers, R L Kauffman, A G MacPhee, P Beiersdorfer, R Bettencourt, T Ma, R C Nora, H A Scott, D B Thorn, J D Kilkenny, D Nelson, M Shoup, Y Maron
A high resolution (E/ΔE = 1200-1800) Bragg crystal x-ray spectrometer is being developed to measure plasma parameters in National Ignition Facility experiments. The instrument will be a diagnostic instrument manipulator positioned cassette designed mainly to infer electron density in compressed capsules from Stark broadening of the helium-β (1s(2)-1s3p) lines of krypton and electron temperature from the relative intensities of dielectronic satellites. Two conically shaped crystals will diffract and focus (1) the Kr Heβ complex and (2) the Heα (1s(2)-1s2p) and Lyα (1s-2p) complexes onto a streak camera photocathode for time resolved measurement, and a third cylindrical or conical crystal will focus the full Heα to Heβ spectral range onto an image plate to provide a time integrated calibration spectrum...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27905606/a-qm-mm-study-of-the-reaction-mechanism-of-human-%C3%AE-ketoacyl-reductase
#6
Fabiola E Medina, Rui P P Neves, Maria J Ramos, Pedro A Fernandes
Human fatty acid synthase (hFAS) is a multifunctional enzyme involved in a wide diversity of biological functions. For instance, it is a precursor of phospholipids and other complex processes such as the de novo synthesis of long chain fatty acid. Human FAS is also a component of biological membranes and it is implicated in the overexpression of several types of cancers. In this work, we describe the catalytic mechanism of β-ketoreductase (KR), which is a catalytic domain of the hFAS enzyme that catalyzes the reduction of β-ketoacyl to β-hydroxyacyl with the concomitant oxidation of the NADPH cofactor...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905600/vuv-photochemistry-of-the-h2oco-complex-in-noble-gas-matrices-formation-of-the-ohco-complex-and-the-hoco-radical
#7
Sergey V Ryazantsev, Luís Duarte, Vladimir I Feldman, Leonid Khriachtchev
Vacuum ultraviolet (VUV, 130-170 nm) photochemistry of the H2OCO complex is studied by matrix-isolation infrared spectroscopy. The H2OCO complexes in Ne, Ar, Kr, and Xe matrices are generated by ultraviolet (UV, 193 and 250 nm) photolysis of formic acid (HCOOH). VUV photolysis of the H2OCO complexes is found to lead to the formation of the OHCO radical-molecule complexes and trans-HOCO radicals. It is shown that the matrix material, local matrix morphology, and possibly the H2OCO complex geometry strongly affect the VUV photolysis pathways...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27900069/validity-of-alcohol-use-disorder-identification-test-korean-revised-version-for-screening-alcohol-use-disorder-according-to-diagnostic-and-statistical-manual-of-mental-disorders-fifth-edition-criteria
#8
Jung Wei Chang, Jong Sung Kim, Jin Gyu Jung, Sung Soo Kim, Seok Joon Yoon, Hak Sun Jang
BACKGROUND: The Alcohol Use Disorder Identification Test (AUDIT) has been widely used to identify alcohol use disorder (AUD). This study evaluated the validity of the AUDIT-Korean revised version (AUDIT-KR) for screening AUD according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria. METHODS: This research was conducted with 443 subjects who visited the Chungnam National University Hospital for a comprehensive medical examination...
November 2016: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/27899563/chimerdb-3-0-an-enhanced-database-for-fusion-genes-from-cancer-transcriptome-and-literature-data-mining
#9
Myunggyo Lee, Kyubum Lee, Namhee Yu, Insu Jang, Ikjung Choi, Pora Kim, Ye Eun Jang, Byounggun Kim, Sunkyu Kim, Byungwook Lee, Jaewoo Kang, Sanghyuk Lee
Fusion gene is an important class of therapeutic targets and prognostic markers in cancer. ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep sequencing data and manual curations. In this update, the database coverage was enhanced considerably by adding two new modules of The Cancer Genome Atlas (TCGA) RNA-Seq analysis and PubMed abstract mining. ChimerDB 3.0 is composed of three modules of ChimerKB, ChimerPub and ChimerSeq. ChimerKB represents a knowledgebase including 1066 fusion genes with manual curation that were compiled from public resources of fusion genes with experimental evidences...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27896533/characteristics-of-higher-order-aberrations-and-anterior-segment-tomography-in-patients-with-pathologic-myopia
#10
Kaori Kasahara, Naoyuki Maeda, Takashi Fujikado, Makoto Tomita, Muka Moriyama, Mutsumi Fuchihata, Kyoko Ohno-Matsui
PURPOSE: To investigate prospectively the characteristics in the higher-order aberrations and anterior segment tomography in patients with pathologic myopia. METHODS: One hundred and twelve consecutive highly myopic patients (mean age 43.4 ± 9.3 years, spherical equivalent of refractive error ≥8 D and an axial length ≥26.5 mm) were studied. Thirty-seven emmetropic individuals (mean age 37.0 ± 14.5 years, spherical equivalent of refractive error ≤ ±1 D) were analyzed as controls...
November 28, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27891542/-ti12in6o18-oocc6h5-30-a-multifunctional-hetero-polyoxotitanate-nanocluster-with-high-stability-and-visible-photoactivity
#11
Shengjun Liu, Wei Hu, Jayanta Kr Nath, Jing Tong, Xudong Hou, Wenlong Liu, Jinlong Yang, Bo Liu
We present a novel strategy to improve the stability and optical absorption of polyoxotitanates (POTs) via concurrently fully carboxylate-coordinating and hetero-metal-doping, and illustrate the strategy by an indium doped hetero-polyoxotitanate (h-POT) of a [Ti12In6O18(OOCC6H5)30] (POTi12In6) nanocluster, which possesses ultrahigh stability in both acid and base aqueous solutions. The nanocluster structurally features a core-shell double wheel structure and a polar cavity. Both experiments and theoretical calculations confirm the semiconductive properties of the nanocluster...
November 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27888780/investigations-of-the-rg-brcl-rg-he-ne-ar-kr-xe-binary-van-der-waals-complexes-ab-initio-intermolecular-potential-energy-surfaces-vibrational-states-and-predicted-pure-rotational-transition-frequencies
#12
Song Li, Rui Zheng, Shan-Jun Chen, Yan Chen, Peng Chen
The intermolecular potential energy surfaces (PESs) of the ground electronic state for the Rg-BrCl (Rg=He, Ne, Ar, Kr, Xe) van der Waals complexes have been constructed by using the coupled-cluster method in combination with the augmented quadruple-zeta correlation-consistent basis sets supplemented with an additional set of bond functions. The features of the anisotropic PESs for these complexes are remarkably similar, which are characterized by three minima and two saddle points between them. The global minimum corresponds to a collinear Rg-Br-Cl configuration...
November 17, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27886371/why-babies-die-in-unplanned-out-of-institution-births-an-enquiry-into-perinatal-deaths-in-norway-1999-2013
#13
Björn Gunnarsson, Sigurd Fasting, Eirik Skogvoll, Alexander Kr Smárason, Kjell Å Salvesen
INTRODUCTION: The aims were to describe causes of death associated with unplanned out-of-institution births, and to study if they could be prevented. MATERIAL AND METHODS: Retrospective population-based observational study based on data from the Medical Birth Registry of Norway and medical records. Between 1 January 1999 and 31 December 2013, 69 perinatal deaths among 6027 unplanned out-of-institution births, whether unplanned at home, during transportation, or unspecified, were selected for enquiry...
November 25, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27885252/a-reliability-generalization-meta-analysis-of-the-leyton-obsessional-inventory-child-version-survey-form
#14
Julio Sánchez-Meca, Isaac Alacid-de-Pascual, José Antonio López-Pina, Juan de la Cruz Sánchez-Jiménez
BACKGROUND: The Leyton Obsessional Inventory Child Version Survey Form (LOI-CV-SF) is a scale created in order to detect obsessive-compulsive symptoms and their effects on the daily lives of children and adolescents from ages 10 to 18 and for the screening of non-clinic infant population. With the purpose of estimating the reliability of the test scores, and how it varies in relation to the characteristics of the studies, a meta-analysis of reliability generalization was carried out. METHODS: A meta-analysis was accomplished...
November 25, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27870695/validity-and-reliability-of-a-submaximal-intermittent-running-test-in-elite-australian-football-players
#15
Kristopher R Veugelers, Geraldine A Naughton, Craig S Duncan, Darren J Burgess, Stuart R Graham
Veugelers, KR, Naughton, GA, Duncan, CS, Burgess, DJ, and Graham, SR. Validity and reliability of a submaximal intermittent running test in elite Australian football players. J Strength Cond Res 30(12): 3347-3353, 2016-The aim of this article was to determine the validity and reliability of a submaximal intermittent running (SIR) test in elite Australian rules football (ARF) players. Heart rate (HR) responses of 38 elite ARF players to both the SIR and the yo-yo intermittent recovery 2 (YYIR2) tests were compared over 2 trials...
December 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27869265/radiation-induced-transformations-of-methanol-molecules-in-low-temperature-solids-a-matrix-isolation-study
#16
Elizaveta V Saenko, Vladimir I Feldman
The effect of X-ray irradiation on methanol molecules (CH3OH, CD3OH, and (13)CH3OH) isolated in solid noble gas matrices (Ne, Ar, Kr, and Xe) was studied by FTIR spectroscopy at 6 K. CH2OH˙, H2CO, HCO˙ and CO were found to be the main degradation products. Somewhat unexpectedly, the production of CO is quite prominent, even at low doses, and it strongly predominates in low-polarizable matrices (especially, in neon). This result is explained by inefficient quenching of excess energy in the H2CO molecules initially generated from methanol...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27866658/effect-of-modulated-electrohyperthermia-on-the-pharmacokinetics-of-oral-transmucosal-fentanyl-citrate-in-healthy-volunteers
#17
Sun Young Lee, Min-Gul Kim
PURPOSE: This study aimed to determine whether changes occur in fentanyl absorption and disposition when administered in conjunction with modulated electrohyperthermia (mEHT) treatment. METHODS: A randomized, single-dose, crossover, open-label study was used to investigate the effect of mEHT on the pharmacokinetic properties of fentanyl in 12 healthy volunteers. The 12 healthy volunteers were each administered a single dose of oral transmucosal fentanyl citrate (OTFC) or a single dose of OTFC with mEHT...
November 17, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27858933/objective-functional-visual-outcomes-of-cataract-surgery-in-patients-with-good-preoperative-visual-acuity
#18
X Zhu, H Ye, W He, J Yang, J Dai, Y Lu
PurposeTo explore the objective functional visual outcomes of cataract surgery in patients with good preoperative visual acuity.MethodsWe enrolled 130 cataract patients whose best-corrected visual acuity (BCVA) was 20/40 or better preoperatively. Objective visual functions were evaluated with a KR-1W analyzer before and at 1 month after cataract surgery.ResultsThe nuclear (N), cortical (C), and N+C groups had very high preoperative ocular and internal total high-order aberrations (HOAs), coma, and abnormal spherical aberrations...
November 18, 2016: Eye
https://www.readbyqxmd.com/read/27856714/nasal-high-flow-reduces-dead-space
#19
Winfried Möller, Sheng Feng, Ulrike Domanski, Karl-Josef Franke, Gülnaz Celik, Peter Bartenstein, Sven Becker, Gabriele Meyer, Otmar Schmid, Oliver Eickelberg, Stanislav Tatkov, Georg Nilius
Recent studies show that nasal high flow (NHF) therapy can support ventilation in patients with acute or chronic respiratory disorders. Clearance of dead-space has been suggested as being the key mechanisms of respiratory support with NHF therapy. The hypothesis of this study was that NHF in a dose-dependent manner can clear dead space of the upper airways from expired air and decrease re-breathing. The randomized cross-over study involved 10 volunteers using scintigraphy with (81m)Krypton-gas ((81m)Kr-gas) during a breath-holding maneuver with closed mouth and in three nasally breathing tracheotomized patients by volumetric capnography and oximetry through sampling CO2 and O2 in the trachea and measuring the inspired volume with inductance plethysmography following NHF rates of 15, 30 and 45 L/min...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27854351/a-mixture-of-extracts-of-kochia-scoparia-and-rosa-multiflora-with-ppar-%C3%AE-%C3%AE-dual-agonistic-effects-prevents-photoaging-in-hairless-mice
#20
Hyerin Jeon, Dong Hye Kim, Youn-Hwa Nho, Ji-Eun Park, Su-Nam Kim, Eung Ho Choi
Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as Kochia scoparia and Rosa multiflora, have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm² and UVB 40 mJ/cm² three times a week for 8 weeks...
November 16, 2016: International Journal of Molecular Sciences
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