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https://www.readbyqxmd.com/read/28718838/phyllanthus-niruri-standardized-extract-alleviates-the-progression-of-non-alcoholic-fatty-liver-disease-and-decreases-atherosclerotic-risk-in-sprague-dawley-rats
#1
Raghdaa Hamdan Al Zarzour, Mariam Ahmad, Mohd Zaini Asmawi, Gurjeet Kaur, Mohammed Ali Ahmed Saeed, Majed Ahmed Al-Mansoub, Sultan Ayesh Mohammed Saghir, Nasiba Salisu Usman, Dhamraa W Al-Dulaimi, Mun Fei Yam
Non-alcoholic fatty liver disease (NAFLD) is one of the major global health issues, strongly correlated with insulin resistance, obesity and oxidative stress. The current study aimed to evaluate anti-NAFLD effects of three different extracts of Phyllanthus niruri (P. niruri). NAFLD was induced in male Sprague-Dawley rats using a special high-fat diet (HFD). A 50% methanolic extract (50% ME) exhibited the highest inhibitory effect against NAFLD progression. It significantly reduced hepatomegaly (16%) and visceral fat weight (22%), decreased NAFLD score, prevented fibrosis, and reduced serum total cholesterol (TC) (48%), low-density lipoprotein (LDL) (65%), free fatty acids (FFAs) (25%), alanine aminotransferase (ALT) (45%), alkaline phosphatase (ALP) (38%), insulin concentration (67%), homeostatic model assessment of insulin resistance (HOMA-IR) (73%), serum atherogenic ratios TC/high-density lipoprotein (HDL) (29%), LDL/HDL (66%) and (TC-HDL)/HDL (64%), hepatic content of cholesterol (43%), triglyceride (29%) and malondialdehyde (MDA) (40%) compared to a non-treated HFD group...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28686869/modeling-the-glomerular-filtration-barrier-are-you-kidney-ing-me
#2
Paola Romagnani, Laura Lasagni
Podocyte depletion drives kidney disease and kidney failure progression, but podocyte complexity at the glomerular filtration barrier is difficult to model in vitro. In Nature Biomedical Engineering, Musah et al. (2017) developed a multifluidic device with iPS-derived podocytes mimicking a functional glomerular filtration barrier that elevates standards for modeling glomerular diseases.
July 6, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28685120/synthesis-spectroscopic-characterization-and-thermogravimetric-analysis-of-two-series-of-substituted-metallo-tetraphenylporphyrins
#3
Rasha K Al-Shewiki, Carola Mende, Roy Buschbeck, Pablo F Siles, Oliver G Schmidt, Tobias Rüffer, Heinrich Lang
Subsequent treatment of H2TPP(CO2H)4 (tetra(p-carboxylic acid phenyl)porphyrin, 1) with an excess of oxalyl chloride and HNR2 afforded H2TPP(C(O)NR2)4 (R = Me, 2; iPr, 3) with yields exceeding 80%. The porphyrins 2 and 3 could be converted to the corresponding metalloporphyrins MTPP(C(O)NR2)4 (R = Me/iPr for M = Zn (2a, 3a); Cu (2b, 3b); Ni (2c, 3c); Co (2d, 3d)) by the addition of 3 equiv of anhydrous MCl2 (M = Zn, Cu, Ni, Co) to dimethylformamide solutions of 2 and 3 at elevated temperatures. Metalloporphyrins 2a-d and 3a-d were obtained in yields exceeding 60% and have been, as well as 2 and 3, characterized by elemental analysis, electrospray ionization mass spectrometry (ESIMS) and IR and UV-vis spectroscopy...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28671476/molecular-group-13-metallaborates-derived-from-m-o-m-cleavage-promoted-by-bh3
#4
Erandi Bernabé-Pablo, Vojtech Jancik, Diego Martínez-Otero, Joaquín Barroso-Flores, Mónica Moya-Cabrera
The reaction of metalloxanes [{(Me)LM(OH)}2(μ-O)] [M = Al (1), Ga (2); (Me)L = CH{CMe(NAr)}2(-), Ar = 2,4,6-Me3C6H2, Me = methyl] with an excess of BH3·D (D = tetrahydrofuran (THF), SMe2) affords annular metallaborate systems achieved through M-O-M cleavage. Compound 1 led exclusively to the formation of eight-membered ring systems [{(Me)LAl(μ-O){B(O(n)Bu)}(μ-O)}2] (3) and [{(Me)LAl(μ-O)(BH)(μ-O)}2] (6), while for 2 the unprecedented six-membered ring systems [{((Me)LGa)2(μ-O)}(μ-O)2{B(O(n)Bu)}] (4) and [((Me)LGa)(μ-O)2{(BO(n)Bu)2(μ-O)}] (5) were observed...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28648891/implications-of-the-vienna-integrated-model-of-art-perception-for-art-based-interventions-in-clinical-populations-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap
#5
https://www.readbyqxmd.com/read/28645699/the-forgotten-artist-why-to-consider-intentions-and-interaction-in-a-model-of-aesthetic-experience-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding
#6
https://www.readbyqxmd.com/read/28622986/top-down-and-bottom-up-front-to-back-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative-and-neurophysiological-correlates-by
#7
https://www.readbyqxmd.com/read/28608579/positive-behavioural-change-requires-clarity-objectivity-and-support
#8
Sue Cradock
The study by Byrne et al. [1] in this edition of Diabetic Medicine reports the results of an extensive survey of healthcare professionals regarding their experience of training support to help people with diabetes. The authors conclude that healthcare professionals are 'insufficiently equipped to provide diabetes self-management education including emotional and psychological aspects of diabetes'. This conclusion prompted me to reflect on how far we have, or rather have not, come in the last decade. This article is protected by copyright...
June 13, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28602723/ugliness-as-the-fourth-wall-breaker-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative-and-neurophysiological-correlates-by
#9
https://www.readbyqxmd.com/read/28602721/adding-gestalt-to-the-picture-comment-on-move-me-astonish-me%C3%A2-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative-and-neurophysiological-correlates-by-matthew
#10
https://www.readbyqxmd.com/read/28595850/learning-dynamics-by-theoretical-tools-of-game-theory-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative-and-neurophysiological
#11
https://www.readbyqxmd.com/read/28578719/stress-sensitivity-in-paranoia-poor-me-paranoia-protects-against-the-unpleasant-effects-of-social-stress
#12
A Udachina, R P Bentall, F Varese, G Rowse
BACKGROUND: The attributional theory of paranoia suggests that paranoid beliefs may protect individuals from low self-esteem and distress (Bentall et al. 2001). The current study tested this theory by investigating a hypothesis that paranoid beliefs in combination with low perceived deservedness of persecution (poor-me beliefs) confer protection against the distress caused by social but not activity related stress. METHODS: Paranoid symptoms, perceived deservedness of persecution, self-esteem, mood, and stress levels of individuals diagnosed with schizophrenia spectrum disorders (N = 91) and healthy controls (N = 52) were assessed in the context of daily life using the experience sampling method...
June 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28566231/representing-the-sublime-in-the-vimap-and-empirical-aesthetics-reviving-edmund-burke-s-a-philosophical-enquiry-into-the-origins-of-our-ideas-of-the-sublime-and-beautiful-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of
#13
https://www.readbyqxmd.com/read/28544664/to-reproduce-or-work-insect-castes-emerge-from-socially-induced-changes-in-nutrition-related-genes
#14
Amy L Toth
In social species, there is a fundamental trade-off between 'me' and 'we'; that is, should I reproduce, or should I work to help others to reproduce? In this issue of Molecular Ecology, Okada et al. () delve into the evolution and genetic mechanisms of this core question, focusing on social caste formation in insects. The authors take advantage of a unique ant in the genus Diacamma, which has secondarily lost the classic, highly different queens and workers found in many other ants, bees and wasps. Instead, Diacamma ant castes are decided via aggressive dominance interactions among adult females, similar to dominance hierarchies seen in primitively social insects and many social vertebrates...
June 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28529777/crystal-structures-of-titanium-aluminium-and-gallium-complexes-bearing-two-%C3%AE-2-ch3-units
#15
Tim Oswald, Mira Diekmann, Annika Frey, Marc Schmidtmann, Rüdiger Beckhaus
The isotypic crystal structures of two titanocene complexes containing an EMe3 unit (E = Al, Ga; Me = meth-yl) with two μ2-coordinating methyl groups, namely [μ-1(η(5))-(adamantan-1-yl-2κC(1))cycylo-penta-dien-yl]di-μ2-methyl-methyl-2κC-[1(η(5))-penta-methyl-cyclo-penta-dien-yl]aluminiumtitanium(III), [AlTi(CH3)3(C10H15)(C15H18)], and [μ-1(η(5))-(adamantan-1-yl-2κC(1))cycylo-penta-dien-yl]di-μ2-methyl-methyl-2κC-[1(η(5))-penta-methyl-cyclo-penta-dien-yl]galliumtitanium(III), [GaTi(CH3)3(C10H15)(C15H18)], are reported...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28528962/which-brain-networks-related-to-art-perception-are-we-talking-about-comment-on-move-me-astonish-me%C3%A2-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative-and
#16
https://www.readbyqxmd.com/read/28526324/on-viewer-motivation-unit-of-analysis-and-the-vimap-comment-on-move-me-astonish-me-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative-and-neurophysiological
#17
https://www.readbyqxmd.com/read/28516209/foreign-language-effect-and-psychological-distance
#18
Hong Im Shin, Juyoung Kim
Does using a foreign language result in forming different moral decisions than using our mother tongue? Two studies were conducted to investigate whether there is a relationship between foreign language effects (differences between native vs. foreign language conditions) and psychological distance. Study 1 tested four moral dilemmas adapted from Greene et al. (Cognition 107: 1144-1155, 2008). Non-fluent Korean-English bilingual participants (N = 161) indicated decisions regarding four moral dilemmas in either Korean or English languages...
May 17, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28486525/hypothesis-driven-single-cell-dual-oscillator-mathematical-model-of-circadian-rhythms
#19
Shiju S, K Sriram
Molecular mechanisms responsible for 24 h circadian oscillations, entrainment to external cues, encoding of day length and the time-of-day effects have been well studied experimentally. However, it is still debated from the molecular network point of view whether each cell in suprachiasmatic nuclei harbors two molecular oscillators, where one tracks dawn and the other tracks dusk activities. A single cell dual morning and evening oscillator was proposed by Daan et al., based on the molecular network that has two sets of similar non-redundant per1/cry1 and per2/cry2 circadian genes and each can independently maintain their endogenous oscillations...
2017: PloS One
https://www.readbyqxmd.com/read/28478916/beauty-and-sublime-comment-on-move-me-astonish-me%C3%A2-delight-my-eyes-and-brain-the-vienna-integrated-model-of-top-down-and-bottom-up-processes-in-art-perception-vimap-and-corresponding-affective-evaluative-and-neurophysiological-correlates-by-matthew-pelowski
#20
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