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https://www.readbyqxmd.com/read/28706765/trauma-and-hypothermia-in-antarctica-an-emergency-medicine-marine-simulation-scenario
#1
Chrystal Horwood, Kerry-Lynn Williams, Tate Skinner, Robert Brown, Tia Renouf, Adam Dubrowski
Simulation has been shown to improve both learner knowledge and patient outcomes. Many emergency medicine training programs incorporate simulation into their curricula to provide learners with experiences that are rare to encounter in practice, yet performance with a high degree of competence is critical. One rare encounter, which is depicted in the report, is the management of a trauma patient who was hypothermic after falling from an expedition vessel into the cold Southern Ocean. The unique scenario presented in this technical report incorporates CanMEDS learning objectives including the communicator, health advocate, and collaborator roles...
June 12, 2017: Curēus
https://www.readbyqxmd.com/read/28701889/education-for-community-based-family-medicine-a-social-need-in-the-real-world
#2
REVIEW
Shin-Ichi Taniguchi, Daeho Park, Kazuoki Inoue, Toshihiro Hamada
One of the most critical social problems in Japan is the remarkable increase in the aging population. Elderly patients with a variety of complications and issues other than biomedical problems such as dementia and life support with nursing care have been also increasing. Ever since the Japanese economy started to decline after the economic bubble burst of 1991 and the Lehman Brothers bankruptcy in 2008, how we can resolve health problems of the elderly at a lower cost has become one of our most challenging social issues...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28677825/the-impact-after-50-years-of-a-new-medical-education-programme-with-a-regional-workforce-mission
#3
Richard Hays, Sarah Bowles, Terry Brown, Anthony Lawler, James Vickers
BACKGROUND: Tasmania established its medical programme in 1965 to produce graduates to address medical workforce recruitment challenges. Many Tasmanian graduates work in Tasmania, but workforce problems continue. This paper reports the workforce outcomes of the first 42 graduating cohorts. METHODS: A database for all University of Tasmania medical graduates from the years 1970 to 2011 was developed by combining information from university, registration and local workforce survey databases...
July 5, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28647189/ethnobotanical-profiling-of-the-medicinal-flora-of-kotli-azad-jammu-and-kashmir-pakistan-empirical-reflections-on-multinomial-logit-specifications
#4
Muhammad Shoaib Amjad, Muhammad Arshad, Abdul Saboor, Sue Page, Sunbal Khalil Chaudhari
OBJECTIVE: To report the indigenous people's uses of plants from a multidimensional perspective in a remote area where strong ethnobotanical cultural practices prevail. METHODS: An ethnobotanical survey was conducted in the field during 2014-2016. Ethnobotanical data were gathered from 182 informants through oral interviews and semi-structured questionnaires. The distribution of plants was explored using both descriptive and graphical methods. Further, a Multinomial Logit Specification was applied to find out the probability of the occurrence of diverse utilization of plants in multipurpose domains...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28639040/mobile-gastrointestinal-and-endoscopic-surgery-in-rural-ecuador-20%C3%A2-years-experience-of-cinterandes
#5
H T Shalabi, M D Price, S T Shalabi, E B Rodas, A L Vicuña, B Guzhñay, R R Price, E Rodas
INTRODUCTION: Five billion people worldwide do not have timely access to surgical care. Cinterandes is one of the only mobile surgical units in low- and middle-income countries. This paper examines the methodology that Cinterandes uses to deliver mobile surgery. METHODS: Founding and core staff were interviewed, four missions were participated in, and internal documents and records were analysed between 1 May and 1 July 2014. RESULTS: Cinterandes performed 7641 operations over the last 20 years (60% gastrointestinal/laparoscopic), travelling 300,000 km to remote areas of Ecuador...
June 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28628725/dendronized-semiconducting-polymer-as-photothermal-nanocarrier-for-remote-activation-of-gene-expression
#6
Yan Lyu, Dong Cui, He Sun, Yansong Miao, Hongwei Duan, Kanyi Pu
Regulation of transgene systems is needed to develop innovative medicines. However, noninvasive remote control of gene expression has been rarely developed and remains challenging. We herein synthesize a near-infrared (NIR) absorbing dendronized semiconducting polymer (DSP) and utilize it as a photothermal nanocarrier not only to efficiently deliver genes but also to spatiotemporally control gene expression in conjunction with heat-inducible promoter. DSP has a high photothermal conversion efficiency (44.2 %) at 808 nm, permitting fast transduction of NIR light into thermal signals for intracellular activation of transcription...
June 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28627850/to-prevent-and-deal-with-medical-problems-on-board
#7
Blaise Genton, Valérie D'Acremont
As more and more quality of life becomes a goal of personnel and sustainable development, long-distance travel is becoming more widespread. Sailing around the world is an example of this evolution. The keys to a successful journey are rigorous preparation and adherence to some prevention rules. Medical or surgical emergencies are rare, and can often be dealt with by remote medical contact. New communication technologies such as satellite phones make it possible to seek medical advice from professionals, or even for sailers to treat themselves with very short prior training, provided that the required equipment and medicines have been embarked before leaving...
May 3, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28614476/integrated-community-case-management-iccm-of-childhood-infection-saves-lives-in-hard-to-reach-communities-in-nicaragua
#8
Dixmer Rivera, Rashed Shah, Tanya Guenther, Meredith Adamo, Jeanne Koepsell, Carmen Maria Reyes, Mary McInerney, David R Marsh
Objective: To describe Nicaragua's integrated community case management (iCCM) program for hard-to-reach, rural communities and to evaluate its impact using monitoring data, including annual, census-based infant mortality data. Method: This observational study measured the strength of iCCM implementation and estimated trends in infant mortality during 2007-2013 in 120 remote Nicaraguan communities where brigadistas ("health brigadiers") offered iCCM services to children 2-59 months old...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28606818/investigating-unlicensed-retail-drug-vendors-preparedness-and-knowledge-about-malaria-an-exploratory-study-in-rural-uganda
#9
Eric Liow, Rosemin Kassam, Richard Sekiwunga
BACKGROUND: Despite major efforts to increase the uptake of preventive measures and timely use of the first line antimalarial treatment artemisinin-based combination therapies (ACT), Uganda continues to fall short of meeting its national malaria control targets. One of the challenges has been scaling up effective measures in rural and remote areas where the unlicensed private retail sector remains the first point of contact and a common source of treatment. The current paper discusses unlicensed vendors' (1) training related to malaria case management for children aged five and under, and (2) knowledge related to the cause of malaria, preventive measures, common signs, and symptoms, diagnostic procedures, and best treatment options...
June 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28601206/prolonged-field-care-beyond-the-golden-hour
#10
REVIEW
Sean Keenan, Jamie C Riesberg
Prolonged field care (PFC) has emerged as a recent area of focus for US military Special Operations Forces (SOF) medical experts. Focused on the current reality of providing medical care to military forces often deployed in remote and austere locations far from medical support or a robust casualty evacuation chain, PFC encompasses evolving operational situations not unlike many wilderness medicine practice environments. SOF currently operates in all areas of the world and on a variety of different missions, which finds these small teams far from the accustomed practice environment of robust deployed medical infrastructure commonly seen during the last 15 years of military conflicts...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28598411/ruthenium-ii-catalysed-remote-c-h-alkylations-as-a-versatile-platform-to-meta-decorated-arenes
#11
Jie Li, Korkit Korvorapun, Suman De Sarkar, Torben Rogge, David J Burns, Svenja Warratz, Lutz Ackermann
The full control of positional selectivity is of prime importance in C-H activation technology. Chelation assistance served as the stimulus for the development of a plethora of ortho-selective arene functionalizations. In sharp contrast, meta-selective C-H functionalizations continue to be scarce, with all ruthenium-catalysed transformations currently requiring difficult to remove or modify nitrogen-containing heterocycles. Herein, we describe a unifying concept to access a wealth of meta-decorated arenes by a unique arene ligand effect in proximity-induced ruthenium(II) C-H activation catalysis...
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28597911/digitizing-medicines-for-remote-capture-of-oral-medication-adherence-using-co-encapsulation
#12
Sara H Browne, Charles Peloquin, Frank Santillo, Richard Haubrich, Leticia Muttera, Kathleen Moser, George Savage, Constance Benson, Terrence Blaschke
High-resolution measurement of medication adherence is essential to personalized drug therapy . An FDA-cleared device, using an edible ingestion sensor (IS), external wearable patch and paired mobile device, can detect and record ingestion events. Oral medications must be combined with an IS to generate precise 'digitized-medication' ingestion records. We developed a GMP-protocol to repackage oral medications with the IS within certified Capsugel® capsules, termed co-encapsulation (CoE). A randomized bioequivalence study of CoE-IS-Rifamate (Isoniazid/Rifampin 150/300mg) versus native-Rifamate was conducted in 12 patients with active Mycobacterium Tuberculosis (MTB) and demonstrated bioequivalence using the population method ratio test (95% CI)...
June 9, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28595645/ethnobotanical-survey-of-medicinal-plants-used-as-insects-repellents-in-six-malaria-endemic-localities-of-cameroon
#13
Roger Ducos Fokouo Youmsi, Patrick Valère Tsouh Fokou, Elisabeth Zeuko'o Menkem, Issakou Bakarnga-Via, Rodrigue Keumoe, Victor Nana, Fabrice Fekam Boyom
BACKGROUND: The combined efforts to combat outdoor/indoor transmission of malaria parasites are hampered by the emerging vector resistance in a wide variety of malaria-endemic settings of Africa and the rest of the world, stressing the need for alternative control measures. This study aimed at documenting insect's repellent plant species used by indigenous populations of 6 localities of East, South, West and Centre regions of Cameroon. METHODS: Information was gathered through face-to-face interviews guided by a semi-structured questionnaire on the knowledge of medicinal plants with insect repellent properties...
June 8, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28590130/paying-the-price-of-desolvation-in-solvent-exposed-protein-pockets-impact-of-distal-solubilizing-groups-on-affinity-and-binding-thermodynamics-in-a-series-of-thermolysin-inhibitors
#14
Jonathan Cramer, Stefan G Krimmer, Andreas Heine, Gerhard Klebe
In lead optimization, open, solvent-exposed protein pockets are often disregarded as prospective binding sites. Because of bulk-solvent proximity, researchers are instead enticed to attach charged polar groups at inhibitor scaffolds to improve solubility and pharmacokinetic properties. It is rarely considered that solvent effects from water reorganization in the first hydration shell of protein-ligand complexes can have a significant impact on binding. We investigate the thermodynamic fingerprint of thermolysin inhibitors featuring terminal charged ammonium groups that are gradually pulled from a distal, solvent-exposed position into the flat, bowl-shaped S2' pocket...
June 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28586720/study-of-galfenol-direct-cytotoxicity-and-remote-microactuation-in-cells
#15
Carolina Vargas-Estevez, Andreu Blanquer, Prabesh Dulal, Rafael Pérez Del Real, Marta Duch, Elena Ibáñez, Leonardo Barrios, Gonzalo Murillo, Núria Torras, Carme Nogués, Bethanie J H Stadler, José A Plaza, Jaume Esteve
Remote microactuators are of great interest in biology and medicine as minimally-invasive tools for cellular stimulation. Remote actuation can be achieved by active magnetostrictive transducers which are capable of changing shape in response to external magnetic fields thereby creating controlled displacements. Among the magnetostrictive materials, Galfenol, the multifaceted iron-based smart material, offers high magnetostriction with robust mechanical properties. In order to explore these capabilities for biomedical applications, it is necessary to study the feasibility of material miniaturization in standard fabrication processes as well as evaluate the biocompatibility...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28578662/possible-contribution-of-quantum-like-correlations-to-the-placebo-effect-consequences-on-blind-trials
#16
Francis Beauvais
BACKGROUND: Factors that participate in the biological changes associated with a placebo are not completely understood. Natural evolution, mean regression, concomitant procedures and other non specific effects are well-known factors that contribute to the "placebo effect". In this article, we suggest that quantum-like correlations predicted by a probabilistic modeling could also play a role. RESULTS: An elementary experiment in biology or medicine comparing the biological changes associated with two placebos is modeled...
June 2, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28577069/prevention-of-acute-kidney-injury-and-protection-of-renal-function-in-the-intensive-care-unit-update-2017-expert-opinion-of-the-working-group-on-prevention-aki-section-european-society-of-intensive-care-medicine
#17
M Joannidis, W Druml, L G Forni, A B J Groeneveld, P M Honore, E Hoste, M Ostermann, H M Oudemans-van Straaten, M Schetz
BACKGROUND: Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity. OBJECTIVES: To determine and update previous recommendations for the prevention of AKI, specifically the role of fluids, diuretics, inotropes, vasopressors/vasodilators, hormonal and nutritional interventions, sedatives, statins, remote ischaemic preconditioning and care bundles. METHOD: A systematic search of the literature was performed for studies published between 1966 and March 2017 using these potential protective strategies in adult patients at risk of AKI...
June 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28574009/potential-biomarkers-for-bipolar-disorder-where-do-we-stand
#18
REVIEW
Rajesh Sagar, Raman Deep Pattanayak
Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the diagnosis of BD is made by history taking, interview and behavioural observations, thereby lacking an objective, biological validation. This approach may result in underdiagnosis, misdiagnosis and eventually poorer outcomes...
January 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28558753/medical-students-career-choices-preference-for-placement-and-attitudes-towards-the-role-of-medical-instruction-in-ethiopia
#19
Tsion Assefa, Damen Haile Mariam, Wubegzier Mekonnen, Miliard Derbew
BACKGROUND: In Ethiopia, the health care delivery and the system of medical education have been expanding rapidly. However, in spite of the expansion, no studies have been carried out among medical students to identify their career choices and attitudes towards the medical instruction. Therefore, this study aimed to fill the gap in evidence in these specific areas. METHODS: Pretested questionnaire was self-administered among fifth and sixth year medical students in six government owned medical schools in Ethiopia...
May 30, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28541383/the-technology-crisis-in-neuropsychology
#20
Justin B Miller, William B Barr
Neuropsychology has fallen reliant on outdated and labor intensive methods of data collection that are slow, highly inefficient, and expensive, and provide relatively data-poor estimates of human behavior despite rapid technological advance in most other fields of medicine. Here we present a brief historical overview of current testing practices in an effort to frame the current crisis, followed by an overview of different settings in which technology can and should be integrated. Potential benefits of laboratory based assessments, remote assessments, as well as passive and high-frequency data collection tools rooted in technology are discussed, along with several relevant examples and how these technologies might be deployed...
May 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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