Tatsuhito Kanda, Kyosuke Kagami, Takashi Iizuka, Haruki Kasama, Takeo Matsumoto, Yuya Sakai, Takuma Suzuki, Megumi Yamamoto, Ayumi Matsuoka, Rena Yamazaki, Akira Hattori, Akihito Horie, Takiko Daikoku, Masanori Ono, Hiroshi Fujiwara
PROBLEM: In the cell column of anchoring villi, the cytotrophoblast differentiates into extravillous trophoblast (EVT) and invades the endometrium in contact with maternal immune cells. Recently, chemokines were proposed to regulate the decidual immune response. To investigate the roles of chemokines around the anchoring villi, we examined the expression profiles of chemokines in the first-trimester trophoblast-derived Swan71 cells using a three-dimensional culture model. METHOD OF STUDY: The gene expressions in the spheroid-formed Swan71 cells were examined by microarray and qPCR analyses...
August 2023: American Journal of Reproductive Immunology: AJRI