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https://www.readbyqxmd.com/read/27930928/human-enterovirus-d68-in-clinical-and-sewage-samples-in-israel
#1
Merav Weil, Michal Mandelboim, Ella Mendelson, Yossi Manor, Lester Shulman, Daniela Ram, Galia Barkai, Yonat Shemer, Dana Wolf, Zipi Kra-Oz, Leah Weiss, Rakefet Pando, Musa Hindiyeh, Danit Sofer
BACKGROUND: Since mid-August 2014, North America experienced a wide outbreak of Enterovirus D68 (EV-D68) associated with severe respiratory illness in children. Several other countries also reported cases of EV-D68 in 2014. OBJECTIVES: The aim of this study was to determine whether EV-D68 circulated in Israel in 2014, caused severe respiratory illness in children and was the causative agent of Acute Flaccid Paralysis. STUDY DESIGN: Archived clinical respiratory samples from a cohort of 710 hospitalized pediatric patient's (<10years old) with respiratory illness were screened for clade B specific EV-D68 by real-time PCR...
November 30, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27862642/external-validation-of-the-pecarn-head-trauma-prediction-rules-in-japan
#2
Kentaro Ide, Satoko Uematsu, Kenichi Tetsuhara, Satoshi Yoshimura, Takahiro Kato, Tohru Kobayashi
OBJECTIVES: The Pediatric Emergency Care Applied Research Network (PECARN) head trauma prediction rules are used to assist computed tomography (CT) decision-making for children with minor head trauma. Although the PECARN rules have been validated in North America and Europe, they have not yet been validated in Asia. In Japan, there are no clinical decision rules for children with minor head trauma. The rate of head CT for children with minor head trauma in Japan is high since CT is widely accessible across the country...
November 12, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27696272/interest-in-collaborative-practice-based-research-networks-in-pediatric-refugee-health-care
#3
Sural Shah, Katherine Yun
Over the last decade, approximately 200,000 refugee children have resettled across the United States. This population is dispersed, resulting in limited data. Collaborative research networks, where clinicians across distinct practice sites work together to answer research questions, can improve the evidence base regarding clinical care. We distributed a web-based survey to pediatric refugee providers around North America to assess priorities, perceived barriers and benefits to collaborative research. We recruited 57 participants...
October 1, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/27610028/respiratory-presentation-of-pediatric-patients-in-the-2014-enterovirus-d68-outbreak
#4
Georgina Martin, Rachel Li, Victoria E Cook, Matthew Carwana, Peter Tilley, Laura Sauve, Patrick Tang, Akshat Kapur, Connie L Yang
Background. In the fall of 2014, a North American outbreak of enterovirus D68 resulted in a significant number of pediatric hospital admissions for respiratory illness throughout North America. This study characterized the clinical presentation and risk factors for a severe clinical course in children admitted to British Columbia Children's Hospital during the 2014 outbreak. Methods. Retrospective chart review of patients with confirmed EV-D68 infection admitted to BCCH with respiratory symptoms in the fall of 2014...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27492669/the-society-of-thoracic-surgeons-congenital-heart-surgery-database-2016-update-on-research
#5
Marshall L Jacobs, Jeffrey P Jacobs, Sara K Pasquali, Kevin D Hill, Christoph Hornik, Sean M O'Brien, David M Shahian, Robert H Habib, Fred H Edwards
The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS CHSD) is the largest congenital and pediatric cardiac surgical clinical data registry in the world. With more than 400,000 total operations from nearly all centers performing pediatric and congenital heart operations in North America, the STS CHSD is an unparalleled platform for clinical investigation, outcomes research, and quality improvement activities in this subspecialty. In 2015, several major original publications reported analyses of data in the CHSD pertaining to specific diagnostic and procedural groups, age-defined cohorts, or the entire population of patients in the database...
September 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27393387/practice-patterns-revisited-in-pediatric-psychosomatic-medicine
#6
Richard J Shaw, Maryland Pao, Jennifer E Holland, David R DeMaso
BACKGROUND: Given the heightened focus on the implementation of integrated care and population health management strategies, there is a critical need for an analysis of pediatric psychosomatic medicine (PPM) programs. OBJECTIVE: The goal was to survey current practice patterns in academic PPM programs in North America regarding their service composition, clinical consultation services, changes in service demand, funding, and major challenges so as to inform and support advocacy efforts on behalf of children in their need for responsive and effective PPM services...
May 21, 2016: Psychosomatics
https://www.readbyqxmd.com/read/27390368/diffuse-alveolar-hemorrhage-as-a-manifestation-of-childhood-onset-systemic-lupus-erythematosus
#7
Saimun Singla, Debra L Canter, Timothy J Vece, Eyal Muscal, Marietta DeGuzman
BACKGROUND: Diffuse alveolar hemorrhage (DAH) is a devastating clinical syndrome characterized by a falling hematocrit, respiratory insufficiency, and radiographic evidence of pulmonary infiltrates. Literature regarding management of DAH in childhood-onset SLE (cSLE) is limited. METHODS: We reviewed the presentation, management, and outcome of DAH in a pediatric tertiary medical center with one of the largest cSLE cohorts in North America. During a 10 year period 7 of 410 children with cSLE had DAH...
August 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27306069/north-american-pediatric-gastroenterology-fellowship-needs-assessment-in-inflammatory-bowel-disease-trainee-and-program-director-perspectives
#8
Jennifer L Dotson, Tolulope Falaiye, Josh B Bricker, Jennifer Strople, Joel Rosh
BACKGROUND: Pediatric inflammatory bowel disease (IBD) care is complex and rapidly evolving. The Crohn's and Colitis Foundation of America and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition cosponsored a needs assessment survey of pediatric gastroenterology trainees and program directors (PDs) to inform on educational programming. METHODS: A Web-based, self-completed survey was provided to North American trainees and PDs during the 2013-2014 academic year...
July 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27282427/targeted-spontaneous-reporting-assessing-opportunities-to-conduct-routine-pharmacovigilance-for-antiretroviral-treatment-on-an-international-scale
#9
Beth Rachlis, Rakhi Karwa, Celia Chema, Sonak Pastakia, Sten Olsson, Kara Wools-Kaloustian, Beatrice Jakait, Mercy Maina, Marcel Yotebieng, Nagalingeswaran Kumarasamy, Aimee Freeman, Nathalie de Rekeneire, Stephany N Duda, Mary-Ann Davies, Paula Braitstein
INTRODUCTION: Targeted spontaneous reporting (TSR) is a pharmacovigilance method that can enhance reporting of adverse drug reactions related to antiretroviral therapy (ART). Minimal data exist on the needs or capacity of facilities to conduct TSR. OBJECTIVES: Using data from the International epidemiologic Databases to Evaluate AIDS (IeDEA) Consortium, the present study had two objectives: (1) to develop a list of facility characteristics that could constitute key assets in the conduct of TSR; (2) to use this list as a starting point to describe the existing capacity of IeDEA-participating facilities to conduct pharmacovigilance through TSR...
October 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27244126/early-operative-versus-delayed-or-nonoperative-treatment-of-anterior-cruciate-ligament-injuries-in-pediatric-patients
#10
Kristina L Dunn, Kenneth C Lam, Tamara C Valovich McLeod
UNLABELLED: Reference: Ramski DE, Kanj WW, Franklin CC, Baldwin KD, Ganley TJ. Anterior cruciate ligament tears in children and adolescents: a meta-analysis of nonoperative versus operative treatment. Am J Sports Med. 2014;42(11):2769-2776. Clinical Questions: In pediatric patients, does early operative treatment of an anterior cruciate ligament (ACL) injury result in decreased knee instability compared with delayed or nonoperative treatment? DATA SOURCES: This review focused on the PubMed/MEDLINE and EMBASE databases...
May 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27135461/thrombopoietin-receptor-agonist-use-in-children-data-from-the-pediatric-itp-consortium-of-north-america-icon2-study
#11
Cindy Neunert, Jenny Despotovic, Kristina Haley, Michele P Lambert, Kerri Nottage, Kristin Shimano, Carolyn Bennett, Robert Klaassen, Kimo Stine, Alexis Thompson, Yves Pastore, Travis Brown, Peter W Forbes, Rachael F Grace
BACKGROUND: Data on second-line treatment options for pediatric patients with immune thrombocytopenia (ITP) are limited. Thrombopoietin receptor agonists (TPO-RA) provide a nonimmunosuppressive option for children who require an increased platelet count. PROCEDURE: We performed a multicenter retrospective study of pediatric ITP patients followed at ITP Consortium of North America (ICON) sites to characterize TPO-RA use. RESULTS: Seventy-nine children had a total of 87 treatments (28 eltrombopag, 43 romiplostim, and eight trialed on both)...
August 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27132463/current-state-of-pediatric-sarcoma-biology-and-opportunities-for-future-discovery-a-report-from-the-sarcoma-translational-research-workshop
#12
REVIEW
Pooja Hingorani, Katherine Janeway, Brian D Crompton, Cigall Kadoch, Crystal L Mackall, Javed Khan, Jack F Shern, Joshua Schiffman, Lisa Mirabello, Sharon A Savage, Marc Ladanyi, Paul Meltzer, Carol J Bult, Peter C Adamson, Philip J Lupo, Rajen Mody, Steven G DuBois, D Williams Parsons, Chand Khanna, Ching Lau, Douglas S Hawkins, R Lor Randall, Malcolm Smith, Poul H Sorensen, Sharon E Plon, Stephen X Skapek, Stephen Lessnick, Richard Gorlick, Damon R Reed
Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time...
May 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27004440/gastroschisis-outcomes-in-north-america-a-comparison-of-canada-and-the-united-states
#13
Fouad Youssef, Li Hsia Alicia Cheong, Sherif Emil
BACKGROUND: Care of infants with gastroschisis is centralized in Canada and noncentralized in the United States. We conducted an outcomes comparison between the two countries and analyzed the determinants of such outcomes. METHODS: Inpatient mortality and hospital stay of gastroschisis patients from the Canadian Pediatric Surgery Network prospective clinical database for the period 2005-2013 were compared with those from the US Kids Inpatient Database for the period 2003-2012...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26976201/prognostic-value-of-medulloblastoma-extent-of-resection-after-accounting-for-molecular-subgroup-a-retrospective-integrated-clinical-and-molecular-analysis
#14
Eric M Thompson, Thomas Hielscher, Eric Bouffet, Marc Remke, Betty Luu, Sridharan Gururangan, Roger E McLendon, Darell D Bigner, Eric S Lipp, Sebastien Perreault, Yoon-Jae Cho, Gerald Grant, Seung-Ki Kim, Ji Yeoun Lee, Amulya A Nageswara Rao, Caterina Giannini, Kay Ka Wai Li, Ho-Keung Ng, Yu Yao, Toshihiro Kumabe, Teiji Tominaga, Wieslawa A Grajkowska, Marta Perek-Polnik, David C Y Low, Wan Tew Seow, Kenneth T E Chang, Jaume Mora, Ian F Pollack, Ronald L Hamilton, Sarah Leary, Andrew S Moore, Wendy J Ingram, Andrew R Hallahan, Anne Jouvet, Michelle Fèvre-Montange, Alexandre Vasiljevic, Cecile Faure-Conter, Tomoko Shofuda, Naoki Kagawa, Naoya Hashimoto, Nada Jabado, Alexander G Weil, Tenzin Gayden, Takafumi Wataya, Tarek Shalaby, Michael Grotzer, Karel Zitterbart, Jaroslav Sterba, Leos Kren, Tibor Hortobágyi, Almos Klekner, Bognár László, Tímea Pócza, Peter Hauser, Ulrich Schüller, Shin Jung, Woo-Youl Jang, Pim J French, Johan M Kros, Marie-Lise C van Veelen, Luca Massimi, Jeffrey R Leonard, Joshua B Rubin, Rajeev Vibhakar, Lola B Chambless, Michael K Cooper, Reid C Thompson, Claudia C Faria, Alice Carvalho, Sofia Nunes, José Pimentel, Xing Fan, Karin M Muraszko, Enrique López-Aguilar, David Lyden, Livia Garzia, David J H Shih, Noriyuki Kijima, Christian Schneider, Jennifer Adamski, Paul A Northcott, Marcel Kool, David T W Jones, Jennifer A Chan, Ana Nikolic, Maria Luisa Garre, Erwin G Van Meir, Satoru Osuka, Jeffrey J Olson, Arman Jahangiri, Brandyn A Castro, Nalin Gupta, William A Weiss, Iska Moxon-Emre, Donald J Mabbott, Alvaro Lassaletta, Cynthia E Hawkins, Uri Tabori, James Drake, Abhaya Kulkarni, Peter Dirks, James T Rutka, Andrey Korshunov, Stefan M Pfister, Roger J Packer, Vijay Ramaswamy, Michael D Taylor
BACKGROUND: Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner. METHODS: We retrospectively identified patients who had a histological diagnosis of medulloblastoma and complete data about extent of resection and survival from centres participating in the Medulloblastoma Advanced Genomics International Consortium...
April 2016: Lancet Oncology
https://www.readbyqxmd.com/read/26967360/pediatric-audiology-in-north-america-current-clinical-practice-and-how-it-relates-to-the-american-academy-of-audiology-pediatric-amplification-guideline
#15
Sheila Moodie, Eileen Rall, Leisha Eiten, George Lindley, Dave Gordey, Lisa Davidson, Marlene Bagatto, Susan Scollie
BACKGROUND: There is broad consensus that screening and diagnosis of permanent hearing loss in children must be embedded within a comprehensive, evidence-based, family-centered intervention program. Clinical practice guidelines (CPGs) for pediatric hearing assessment and hearing aid verification aim to reduce variability in practice and increase the use of effective evidence-based diagnostic and treatment options so that optimal outcomes may be achieved. To be of value, guidelines must be translated and implemented into practice and ongoing monitoring of their use in practice should occur...
March 2016: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/26935868/ev-d68-infection-in-children-with-asthma-exacerbation-and-pneumonia-in-mexico-city-during-2014-autumn
#16
Joel A Vazquez-Perez, Jose E Ramirez-Gonzalez, Yazmin Moreno-Valencia, Victor A Hernandez-Hernandez, Jose A I Romero-Espinoza, Manuel Castillejos-Lopez, Andres Hernandez, Rogelio Perez-Padilla, Lizbeth E Oropeza-Lopez, Noe Escobar-Escamilla, Maribel Gonzalez-Villa, Alejandro Alejandre-Garcia, Justino Regalado-Pineda, Patricio Santillan-Doherty, Irma Lopez-Martínez, Alberto Diaz-Quiñonez, Jorge Salas-Hernandez
BACKGROUND: Human enterovirus D68 (EV-D68) recently caused an increase in mild-to-severe pediatric respiratory cases in North America and some European countries. Even though few of these children presented with acute paralytic disease, direct causal relationship cannot yet be assumed. OBJECTIVES: The purposes of this report were to describe the clinical findings of an outbreak of EV-D68 infection in Mexico City and identify the genetic relationship with previously reported strains...
May 2016: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/26925711/current-practice-of-pharmacological-thromboprophylaxis-for-prevention-of-venous-thromboembolism-in-hospitalized-children-a-survey-of-pediatric-hemostasis-and-thrombosis-experts-in-north-america
#17
Sherif M Badawy, Karen Rychlik, Anjali A Sharathkumar
Pharmacological thromboprophylaxis (pTP) is the most effective intervention to prevent venous thromboembolism (VTE) in hospitalized adults. High-quality studies investigating the role of pTP in children are lacking. The aim of this study is to understand pediatric hematologists' current practices of pTP prescription and to explore their opinion about universal adoption of pTP for high-risk hospitalized children. An electronic survey was sent to members of Hemostasis and Thrombosis Research Society of North America...
May 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/26828647/a-systematic-review-of-the-cost-and-cost-effectiveness-studies-of-proton-radiotherapy
#18
REVIEW
Vivek Verma, Mark V Mishra, Minesh P Mehta
BACKGROUND: Economic analyses of new technologies, such as proton-beam radiotherapy (PBT), are a public health priority. To date, no systematic review of the cost-effectiveness of PBT has been performed. METHODS: Systematic searches of PubMed, EMBASE, abstracts from American Society for Radiation Oncology and American Society of Clinical Oncology meetings, and the Cost-Effectiveness Analysis Registry were conducted (2000-2015) along with abstracts from the Particle Therapy Co-Operative Group of North America for both years of existence (2014-2015)...
May 15, 2016: Cancer
https://www.readbyqxmd.com/read/26795358/-upgrading-a-pediatric-pharmaceutical-care-service-in-quebec
#19
A Leroux, A Guérin, J-F Bussières, D Lebel, S Tremblay, H Roy, M-E Métras, M Beauchemin, P Bédard
INTRODUCTION: Clinical pharmacy has developed since the 1960s in North America, with large disparities in the presence of decentralized pharmacists in hospital units between healthcare programs. Decentralized pharmacists have been present in pediatrics since the 1970s. The main objective of this study was to describe the steps used to upgrade the pediatrics department's pharmaceutical care. METHODS: A descriptive study was conducted to upgrade the pharmaceutical care provided by two full-time equivalents in two pediatric sectors including 81 beds of a tertiary mother-child hospital...
February 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/26654514/a-systematic-review-of-clinical-practice-guidelines-recommendations-on-levothyroxine-therapy-alone-versus-combination-therapy-lt4-plus-lt3-for-hypothyroidism
#20
REVIEW
Eyal Kraut, Pendar Farahani
PURPOSE: Patients with hypothyroidism are increasingly enquiring about the benefit of using combination therapy of levothyroxine (LT4) and liothyronine (LT3) as a potential treatment for hypothyroidism. Combination therapy, however, remains controversial. The purpose of this study was to systematically review available hypothyroidism treatment recommendations from clinical practice guidelines from around the world to identify the consensus regarding combination therapy. SOURCE: Clinical practice guidelines were obtained from searches of PubMed, EMBASE, and MEDLINE, using several combinations of MeSH terms...
December 4, 2015: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
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