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https://www.readbyqxmd.com/read/28166609/modulating-immunogenicity-of-factor-ix-by-fusion-to-an-immunoglobulin-fc-domain-a-study-using-hemophilia-b-mouse-model
#1
Ditza Levin, H A Daniel Lagassé, Erin Burch, Scott Strome, Siyuan Tan, Haiyan Jiang, Zuben E Sauna, Basil Golding
BACKGROUND: Fc-fusion is a platform technology used to increase the circulating half-life of protein and peptide therapeutics. However, there are potential immunological consequences with this approach, such as changes in the molecule's immunogenicity as well as possible interactions with a repertoire of Fc-receptors (FcR) which can modulate immune responses. OBJECTIVES/METHODS: Using a mouse hemophilia B (HB) model, we compared the immune responses to infusions of recombinant human Factor IX (hFIX) and hFIX fused to mouse IgG2a-Fc (hFIX-mFc)...
February 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28095955/preconditioning-to-reduce-decompression-stress-in-scuba-divers
#2
Peter Germonpré, Costantino Balestra
BACKGROUND: Using ultrasound imaging, vascular gas emboli (VGE) are observed after asymptomatic scuba dives and are considered a key element in the potential development of decompression sickness (DCS). Diving is also accompanied with vascular dysfunction, as measured by flow-mediated dilation (FMD). Previous studies showed significant intersubject variability to VGE for the same diving exposure and demonstrated that VGE can be reduced with even a single pre-dive intervention. Several preconditioning methods have been reported recently, seemingly acting either on VGE quantity or on endothelial inflammatory markers...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28077675/post-hoc-assessment-of-the-immunogenicity-of-bioengineered-factor-viia-demonstrates-the-use-of-preclinical-tools
#3
Kasper Lamberth, Stine Louise Reedtz-Runge, Jonathan Simon, Ksenia Klementyeva, Gouri Shankar Pandey, Søren Berg Padkjær, Véronique Pascal, Ileana R León, Charlotte Nini Gudme, Søren Buus, Zuben E Sauna
Immunogenicity is an important consideration in the licensure of a therapeutic protein because the development of neutralizing anti-drug antibodies (ADAs) can affect both safety and efficacy. Neoantigens introduced by bioengineering of a protein drug are a particular cause for concern. The development of a bioengineered recombinant factor VIIa (rFVIIa) analog was discontinued after phase 3 trials because of the development of ADAs. The unmodified parent molecule (rFVIIa), on the other hand, has been successfully used as a drug for more than two decades with no reports of immunogenicity in congenital hemophilia patients with inhibitors...
January 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28035584/from-lab-to-real-world-heat-acclimation-considerations-for-elite-athletes
#4
Julia R Casadio, Andrew E Kilding, James D Cotter, Paul B Laursen
As major sporting events are often held in hot environments, increased interest in ways of optimally heat acclimating athletes to maximise performance has emerged. Heat acclimation involves repeated exercise sessions in hot conditions that induce physiological and thermoregulatory adaptations that attenuate heat-induced performance impairments. Current evidence-based guidelines for heat acclimation are clear, but the application of these recommendations is not always aligned with the time commitments and training priorities of elite athletes...
December 29, 2016: Sports Medicine
https://www.readbyqxmd.com/read/28008544/the-where-and-how-for-reaching-transgender-women-and-men-who-have-sex-with-men-with-hiv-prevention-services-in-guatemala
#5
William M Miller, William C Miller, Clare Barrington, Sharon S Weir, Sanny Y Chen, Michael E Emch, Audrey E Pettifor, Gabriela Paz-Bailey
This study aims to describe the transgender women and men who have sex with men (MSM) missed through venue-based sampling and illustrate how data on venues can be used to prioritize service delivery. Respondent-driven sampling (RDS) and time-location sampling (TLS) were used concurrently in 2010 for behavioral surveillance among MSM and transgender women in Guatemala City. RDS recruits who did not frequent venues (n = 106) were compared to TLS recruits (n = 609). TLS participants recruited at different types of venues were compared...
December 22, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/28007939/single-synonymous-mutation-in-factor-ix-alters-protein-properties-and-underlies-haemophilia-b
#6
Vijaya L Simhadri, Nobuko Hamasaki-Katagiri, Brian C Lin, Ryan Hunt, Sujata Jha, Sandra C Tseng, Andrew Wu, Amber A Bentley, Ran Zichel, Qi Lu, Lily Zhu, Darón I Freedberg, Dougald M Monroe, Zuben E Sauna, Robert Peters, Anton A Komar, Chava Kimchi-Sarfaty
BACKGROUND: Haemophilia B is caused by genetic aberrations in the F9 gene. The majority of these are non-synonymous mutations that alter the primary structure of blood coagulation factor IX (FIX). However, a synonymous mutation c.459G>A (Val107Val) was clinically reported to result in mild haemophilia B (FIX coagulant activity 15%-20% of normal). The F9 mRNA of these patients showed no skipping or retention of introns and/or change in mRNA levels, suggesting that mRNA integrity does not contribute to the origin of the disease in affected individuals...
December 22, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27932366/sauna-bathing-is-inversely-associated-with-dementia-and-alzheimer-s-disease-in-middle-aged-finnish-men
#7
Tanjaniina Laukkanen, Setor Kunutsor, Jussi Kauhanen, Jari Antero Laukkanen
BACKGROUND: there are no previous studies linking repeated heat exposure of sauna and the risk of memory diseases. We aimed to investigate whether frequency of sauna bathing is associated with risk of dementia and Alzheimer's disease. SETTING: prospective population-based study. METHODS: the frequency of sauna bathing was assessed at baseline in the Kuopio Ischaemic Heart Disease population-based prospective cohort study of 2,315 apparently healthy men aged 42-60 years at baseline, with baseline examinations conducted between 1984 and 1989...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27908322/-traumatic-bilateral-posterior-shoulder-dislocation-after-a-seizure
#8
Mazaher Azizpour, Peter Anton Suder, Rebekka Fonnesbæk
We report a rare case in which a 52-year-old man was found lying on the floor of a sauna. He was confused and complained of pain in both shoulders. He had previously had surgery of a benign meningioma. The initial X-ray examination of both shoulders showed bilateral posterior shoulder dislocation, but no fractures were detected. An attempt to reposition the shoulder dislocation was performed but with no success. Intraoperative examination on the next day detected bilateral fractures with partially destroyed joint head...
November 28, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27893354/summary-report-of-the-first-international-conference-on-inhibitors-in-haemophilia-a
#9
Sebastien Lacroix-Desmazes, David W Scott, Jenny Goudemand, Marijke Van Den Berg, Michael Makris, Alice S Van Velzen, Elena Santagostino, David Lillicrap, Frits R Rosendaal, Anneliese Hilger, Zuben E Sauna, Johannes Oldenburg, Lorenzo Mantovani, M Elisa Mancuso, Craig Kessler, Charles R M Hay, Paul Knoebl, Giovanni Di Minno, Keith Hoots, Amanda Bok, Mark Brooker, Erica Buoso, Pier Mannuccio Mannucci, Flora Peyvandi
No abstract text is available yet for this article.
November 25, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27855485/active-targeted-hiv-testing-and-linkage-to-care-among-men-who-have-sex-with-men-attending-a-gay-sauna-in-thailand
#10
Thana Khawcharoenporn, Anucha Apisarnthanarak, Nittaya Phanuphak
Existing data on the feasibility of human immunodeficiency virus (HIV) testing and counseling (HTC) and linkage to care among men who have sex with men (MSM) in hotspots are currently limited. A prospective study on active targeted HTC and linkage to care among MSM (≥18 years old) was conducted at a gay sauna in Thailand from November 2013 to October 2015. HIV risks and risk perception were evaluated through an anonymous survey. HIV testing with result notification and care appointment arrangement were provided on-site...
November 17, 2016: AIDS Care
https://www.readbyqxmd.com/read/27710145/extreme-rapid-weight-loss-and-rapid-weight-gain-observed-in-uk-mixed-martial-arts-athletes-preparing-for-competition
#11
Joseph John Matthews, Ceri Nicholas
There is a lack of research documenting the weight-making practices of mixed-martial-arts (MMA) competitors. The purpose of the investigation was to quantify the magnitude and identify the methods of rapid weight loss (RWL) and rapid weight gain (RWG) in MMA athletes preparing for competition. Seven athletes (mean ± SD, age 24.6 ± 3.5 yrs, body mass 69.9 ± 5.7 kg, competitive experience 3.1 ± 2.2 yrs) participated in a repeated-measures design. Measures of dietary intake, urinary hydration status, and body mass were recorded in the week preceding competition...
October 6, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27451475/saunas-may-reduce-risk-of-sudden-death
#12
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Mayo Clinic Health Letter
https://www.readbyqxmd.com/read/27418688/passive-heat-therapy-improves-cutaneous-microvascular-function-in-sedentary-humans-via-improved-nitric-oxide-dependent-dilation
#13
Vienna E Brunt, Taylor M Eymann, Michael A Francisco, Matthew J Howard, Christopher T Minson
Passive heat therapy (repeated hot tub or sauna use) reduces cardiovascular risk, but its effects on the mechanisms underlying improvements in microvascular function have yet to be studied. We investigated the effects of heat therapy on microvascular function and whether improvements were related to changes in nitric oxide (NO) bioavailability using cutaneous microdialysis. Eighteen young, sedentary, otherwise healthy subjects participated in 8 wk of heat therapy (hot water immersion to maintain rectal temperature ≥38...
September 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27234859/-changes-of-chosen-physiological-parameters-in-young-healthy-persons-after-sauna-bathing-procedures
#14
Jarosław Pasek, Grzegorz Cieślar, Sebastian Szajkowski, Leszek Jagodziński, Aleksander Sieroń
UNLABELLED: The profitable influence of sauna bathing interventions on functional human organism has been known for many years. However, range of argumentation wakes up the influence of sauna bathing procedures on heart action. This questions concerns the frequency of heart action, minute heart volume as well as the parameters of arterial blood pressure. AIM: The aim of the study was to evaluate a changes of some cardiac parameters after sauna bathing. MATERIALS AND METHODS: The study group was changes of physiological parameters pulse, arterial blood pressure as well as the temperature of body at 44 young the healthy persons (22 men and 22 women) in age 20-25 years (the average age 22,3±1,2 years) executed...
May 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27147613/outbreak-of-syphilis-in-men-who-have-sex-with-men-living-in-rural-north-wales-uk-associated-with-the-use-of-social-media
#15
Daniel Rh Thomas, Christopher J Williams, Ushan Andrady, Valerie Anderson, Sioned Humphreys, Claire M Midgley, Laia Fina, Noel Craine, Gary Porter-Jones, Alison Wilde, Chris Whiteside
OBJECTIVES: To describe an outbreak of infectious syphilis in rural North Wales and the control measures implemented. METHODS: Following reports of an increase of syphilis in North Wales, a multidisciplinary Outbreak Control Team (OCT) was established. A multilevel prevention and control response was initiated, including: active case surveillance, partner notification and treatment, sexual network analysis, awareness raising with professionals and affected communities, point-of-care syphilis testing at a sauna and a health promotion campaign targeting users of men who have sex with men (MSM) social network mobile phone applications (apps)...
August 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27136904/pharmacokinetics-and-adhesion-of-a-transdermal-patch-containing-ethinyl-estradiol-and-gestodene-under-conditions-of-heat-humidity-and-exercise-a-single-center-open-label-randomized-crossover-study
#16
Christian Zurth, Barbara Schuett, Manuela Casjens, Matthias Ludwig, Katrin Waellnitz
In this open-label, randomized study, 36 women (18-45 years) applied an ethinyl estradiol/gestodene contraceptive patch once-weekly for 3 weeks followed by a 1-week, patch-free interval, in 3 treatment periods. The primary objective was to evaluate the pharmacokinetics of ethinyl estradiol and gestodene under conditions of heat, humidity, and exercise. The secondary objective was to evaluate patch adhesion under the same conditions. Weeks 1 and 2 of each period comprised "standardized normal activity" (SNA); in week 3, SNA continued or women used a sauna, whirlpool, swimming pool, or performed an exercise combination...
July 2015: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/27115604/condomless-vaginal-intercourse-and-its-associates-among-men-who-have-sex-with-men-in-china
#17
Hongcheng Shen, Songyuan Tang, Tanmay Mahapatra, Joseph D Tucker, Shujie Huang, Bin Yang, Jinkou Zhao, Roger Detels, Weiming Tang
BACKGROUND: HIV prevalence has increased rapidly among men who have sex with men (MSM) in China reaching alarmingly high levels in some cities. Bisexual MSM have potential to transmit HIV and syphilis to their female partners through condomless vaginal intercourse (CVI). Thus, estimation of the burden of CVI and identification of its associates seemed necessary to control this cross-gender transmission. METHOD: In a cross-sectional study, using respondent-driven-sampling and snowball sampling, 2958 MSM were recruited from seven Chinese cities, interviewed and tested for HIV and syphilis...
2016: PloS One
https://www.readbyqxmd.com/read/27070776/new-insights-in-professional-horse-racing-in-race-heart-rate-data-elevated-fracture-risk-hydration-nutritional-and-lifestyle-analysis-of-elite-professional-jockeys
#18
John O'Reilly, Hoi Lun Cheng, Eric Tsz-Chun Poon
Weight-making practices have been shown to impair musculoskeletal and physiological function of jockeys. This study investigated the "in-race" heart rate (HR) responses and hydration status during competitive racing, as well as selected physiological and lifestyle parameters of professional jockeys based in Hong Kong. "In-race" HR responses and early morning hydration status of 20 male jockeys were examined in hot and moderate climactic occasions. Additionally, bone mineral density (BMD), dietary intake and lifestyle choices were assessed...
March 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27001189/waon-therapy-for-managing-chronic-heart-failure%C3%A3-results-from-a-multicenter-prospective-randomized-waon-chf-study
#19
RANDOMIZED CONTROLLED TRIAL
Chuwa Tei, Teruhiko Imamura, Koichiro Kinugawa, Teruo Inoue, Tohru Masuyama, Hiroshi Inoue, Hirofumi Noike, Toshihiro Muramatsu, Yasuchika Takeishi, Keijiro Saku, Kazumasa Harada, Hiroyuki Daida, Youichi Kobayashi, Nobuhisa Hagiwara, Masatoshi Nagayama, Shinichi Momomura, Kazuya Yonezawa, Hiroshi Ito, Satoshi Gojo, Makoto Akaishi, Masaaki Miyata, Mitsuru Ohishi
BACKGROUND: Waon therapy improves heart failure (HF) symptoms, but further evidence in patients with advanced HF remains uncertain. METHODS AND RESULTS: In 19 institutes, we prospectively enrolled hospitalized patients with advanced HF, who had plasma levels of B-type natriuretic peptide (BNP) >500 pg/ml on admission and BNP >300 pg/ml regardless of more than 1 week of medical therapy. Enrolled patients were randomized into Waon therapy or control groups...
2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26957952/muscle-contraction-velocity-strength-and-power-output-changes-following-different-degrees-of-hypohydration-in-competitive-olympic-combat-sports
#20
J G Pallarés, A Martínez-Abellán, J M López-Gullón, R Morán-Navarro, E De la Cruz-Sánchez, R Mora-Rodríguez
BACKGROUND: It is habitual for combat sports athletes to lose weight rapidly to get into a lower weight class. Fluid restriction, dehydration by sweating (sauna or exercise) and the use of diuretics are among the most recurrent means of weight cutting. Although it is difficult to dissuade athletes from this practice due to the possible negative effect of severe dehydration on their health, athletes may be receptive to avoid weight cutting if there is evidence that it could affect their muscle performance...
2016: Journal of the International Society of Sports Nutrition
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