Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
REVIEW
Jari A Laukkanen, Setor K Kunutsor
Passive heat therapy is characterized by exposure to a high environmental temperature for a brief period. There are several types of passive heat therapy which include hot tubs, Waon therapy, hydrotherapy, sanarium, steam baths, infrared saunas and Finnish saunas. The most commonly used and widely studied till date are the Finnish saunas, which are characterized by high temperatures (ranging from 80-100°C) and dry air with relative humidity varying from 10-20%. The goal of this review is to provide a summary of the current evidence on the impact of passive heat therapies particularly Finnish saunas on various health outcomes, while acknowledging the potential of these therapies to contribute to the extension of healthspan, based on their demonstrated health benefits and disease prevention capabilities...
2024: Temperature: Multidisciplinary Biomedical Journal
#2
JOURNAL ARTICLE
Elizabeth Chun, Annie Crete, Christopher Neal, Richard Joseph, Rachele Pojednic
Wellness-centric proactive healthcare is increasingly sought after, with individuals frequently embracing complementary modalities to achieve this goal. In this six-month study, healthy adult participants (n = 25) received specific therapies, including whole-body cryotherapy, infrared sauna, and photobiomodulation, along with guidance on physical activity, diet, and alcohol intake. Serum biomarkers were measured for all participants, while a subset also received biometric assessments for body composition (n = 10) and heart rate variability (n = 7)...
March 18, 2024: Healthcare (Basel, Switzerland)
#3
REVIEW
Roopali Dahiya, Maryam Asif, Sharanya E Santhi, Amna Hashmi, Awranoos Ahadi, Zara Arshad, Faisal Nawaz, Rahul Kashyap
Heat therapy, including saunas, jacuzzi, and hot tub bathing, has gained global popularity. However, the escalating incidents of injuries and fatalities associated with hot tub activities are a significant public health concern. This study aims to comprehensively review and analyze the pathophysiological factors contributing to hot tub-related deaths, addressing the need for awareness and mitigation strategies. A comprehensive search of electronic databases, PubMed and Science Direct, was conducted to identify articles relevant to bath-related deaths...
February 2024: Curēus
#4
JOURNAL ARTICLE
Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P Lotz, Laurent Malherbe, Lydia Michaut, Karin N Weldingh, Joao A Pedras-Vasconcelos, Laura I Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi, Daniel Kramer
Biologics have revolutionized disease management in many therapeutic areas by addressing unmet medical needs and overcoming resistance to standard-of-care treatment in numerous patients. However, the development of unwanted immune responses directed against these drugs, humoral and/or cellular, can hinder their efficacy and have safety consequences with various degrees of severity. Health authorities ask that a thorough immunogenicity risk assessment be conducted during drug development to incorporate an appropriate monitoring and mitigation plan in clinical studies...
2024: MAbs
#5
JOURNAL ARTICLE
Wencel Valega-Mackenzie, Marisabel Rodriguez Messan, Osman N Yogurtcu, Ujwani Nukala, Zuben E Sauna, Hong Yang
The advancements in next-generation sequencing have made it possible to effectively detect somatic mutations, which has led to the development of personalized neoantigen cancer vaccines that are tailored to the unique variants found in a patient's cancer. These vaccines can provide significant clinical benefit by leveraging the patient's immune response to eliminate malignant cells. However, determining the optimal vaccine dose for each patient is a challenge due to the heterogeneity of tumors. To address this challenge, we formulate a mathematical dose optimization problem based on a previous mathematical model that encompasses the immune response cascade produced by the vaccine in a patient...
March 1, 2024: PLoS Computational Biology
#6
JOURNAL ARTICLE
Setor K Kunutsor, Sae Young Jae, Sudhir Kurl, Jari A Laukkanen
Objectives : This cohort study aimed to investigate the potential interplay between systolic blood pressure (SBP), frequency of sauna bathing (FSB), and all-cause mortality risk among Caucasian men. Design : A prospective study was conducted, involving 2575 men aged 42 to 61 years. Baseline assessments included resting blood pressure measurements and self-reported sauna bathing habits. SBP levels were categorized as normal (<140 mmHg) or high (≥140 mmHg), while FSB was classified as low (≤2 sessions/week) or high (3-7 sessions/week)...
December 2024: Scandinavian Cardiovascular Journal: SCJ
#7
REVIEW
Helena Trevisan Schroeder, Carlos Henrique De Lemos Muller, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt
Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition characterizes a spectrum of debilitating conditions, including insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments. This manuscript explores a range of physiological, pharmacological, and nutraceutical interventions aimed at reinstating the HSR in the context of chronic low-grade inflammation, as well as protocols to assess the HSR...
February 2024: Cell Stress & Chaperones
#8
REVIEW
Patrick Rodrigues, Lucas B R Orssatto, Daniel Gagnon, Amine Dahhak, Anne Hecksteden, Ian B Stewart, Geoffrey M Minett
The world is experiencing increased frequency, duration, and severity of life-threatening heat extremes. Most hospitalizations and excess deaths during extreme heat events are associated with pre-existing diseases in older adults. As climate change persists, the global population ages, and the number of individuals with chronic diseases expands, more people are at risk of adverse health outcomes during extreme heat events. Therefore, proactive preventive measures are urgently needed to mitigate heat-related health risks within these populations...
February 1, 2024: Journal of Applied Physiology
#9
JOURNAL ARTICLE
Olivia K Leach, Kaitlyn Strong, Gary W Mack, Jayson R Gifford
Sauna has been linked to a reduction of cardiovascular disease risk and is a promising non-pharmacological treatment for populations at risk of cardiovascular disease. This study examined the vascular response to an acute bout of sauna heating in young and middle-aged individuals. Ten young (25 ± 4 years, 6 males and 4 females) and 8 middle-aged adults (56 ± 4 years, 4 males and 4 females) underwent 40 min of sauna exposure at 80 ºC. Esophageal and intramuscular temperatures, brachial and superficial femoral artery blood flow, artery diameter, and shear rates were recorded at baseline and following heat exposure...
January 25, 2024: Journal of Applied Physiology
#10
JOURNAL ARTICLE
Colin S Doherty, Lauren V Fortington, Oliver R Barley
This study investigated (a) differences between males and females for changes in serum, tear, and urine osmolality, hematocrit, and urine specific gravity following acute passive dehydration and (b) assessed the reliability of these biomarkers separately for each sex. Fifteen males (age: 26.3 ± 3.5 years, body mass: 76 ± 7 kg) and 15 females (age: 28.8 ± 6.4 years, body mass: 63 ± 7 kg) completed a sauna protocol twice (5-28 days apart), aiming for 4% body mass loss (BML)...
March 1, 2024: International Journal of Sport Nutrition and Exercise Metabolism
#11
JOURNAL ARTICLE
Catherine Apio, Kyulhee Han, Doeun Lee, Bogyeom Lee, Taesung Park
BACKGROUND: In the absence of an effective treatment method or vaccine, the outbreak of the COVID-19 pandemic elicited a wide range of unprecedented restriction policies aimed at mitigating and suppressing the spread of the SARS-CoV-2 virus. These policies and their Stringency Index (SI) of more than 160 countries were systematically recorded in the Oxford COVID-19 Government Response Tracker (OxCGRT) data set. The SI is a summary measure of the overall strictness of these policies. However, the OxCGRT SI may not fully reflect the stringency levels of the restriction policies implemented in Korea...
January 8, 2024: JMIR Public Health and Surveillance
#12
REVIEW
Yanxia Mao, Qian Gao, Ying Zhang, Yan Yue, Tiechao Ruan, Yi Yang, Tao Xiong
BACKGROUND: Hypertensive disorders in pregnancy (HDP) are a major cause of maternal mortality and morbidity. Recent studies indicated that pregnant women are the most vulnerable populations to ambient temperature influences, but it affected HDP with inconsistent conclusions. Our objective is to systematically review whether extreme temperature exposure is associated with a changed risk for HDP. METHOD: We searched PubMed, EMBASE, Web of Science and Cochrane Library databases...
December 2023: Hypertension in Pregnancy
#13
JOURNAL ARTICLE
Ming Chang, Takuya Ibaraki, Yasushi Naruse, Yasuhiko Imamura
Saunas are becoming increasingly popular worldwide, being an activity that promotes relaxation and health. Intense feelings of happiness have been reported shortly after enjoying a hot sauna and cold water, what is known in Japan as the "totonou" state. However, no research has investigated what occurs in the brain during the "totonou" state. In the present study, participants underwent a sauna phase, consisting of three sets of alternating hot sauna, cold water, and rest. We elucidated changes in brain activity and mood in the "totonou" state by measuring and comparing brain activity and emotional scales before and after the sauna phase and during the rest phase in each set...
2023: PloS One
#14
REVIEW
Matthew Driller, Alana Leabeater
The sport and athletic performance industry has seen a plethora of new recovery devices and technologies over recent years, and it has become somewhat difficult for athletes, coaches, and practitioners to navigate the efficacy of such devices or whether they are even required at all. With the increase in recovery devices and tools, it has also become commonplace for athletes to overlook more traditional, well-established recovery strategies. In this narrative review, we discuss recovery strategies in relation to the hierarchy of scientific evidence, classifying them based on the strength of the evidence, ranging from meta-analyses through to case studies and reports...
November 3, 2023: Sports
#15
JOURNAL ARTICLE
A G B Willmott, C A James, M Hayes, N S Maxwell, J Roberts, O R Gibson
INTRODUCTION: Passive heating is receiving increasing attention within human performance and health contexts. A low-cost, portable steam sauna pod may offer an additional tool for those seeking to manipulate physiological (cardiovascular, thermoregulatory and sudomotor) and perceptual responses for improving sporting or health profiles. This study aimed to 1) report the different levels of heat stress and determine the pods' inter-unit reliability, and 2) quantify the reliability of physiological and perceptual responses to passive heating...
October 31, 2023: Journal of Thermal Biology
#16
JOURNAL ARTICLE
Wojciech Jankowski, Christopher Kidchob, Campbell Bunce, Edward Cloake, Ricardo Resende, Zuben E Sauna
The propensity of therapeutic proteins to elicit an immune response, poses a significant challenge in clinical development and safety of the patients. Assessment of immunogenicity is crucial to predict potential adverse events and design safer biologics. In this study, we employed MHC Associated Peptide Proteomics (MAPPS) to comprehensively evaluate the immunogenic potential of re-engineered variants of immunogenic FVIIa analog (Vatreptacog Alfa). Our finding revealed the correlation between the protein sequence affinity for MHCII and the number of peptides identified in a MAPPS assay and this further correlates with the reduced T-cell responses...
2023: Frontiers in Immunology
#17
REVIEW
Justine C Noel, Daniel Lagassé, Basil Golding, Zuben E Sauna
Immunogenicity affects the safety and efficacy of therapeutic proteins. This review is focused on approaches for inducing immunological tolerance to circumvent the immunogenicity of therapeutic proteins in the clinic. The few immune tolerance strategies that are used in the clinic tend to be inefficient and expensive and typically involve global immunosuppression, putting patients at risk of infections. The hallmark of a desirable immune tolerance regimen is the specific alleviation of immune responses to the therapeutic protein...
October 28, 2023: Trends in Pharmacological Sciences
#18
Nancy E Hernandez, Wojciech Jankowski, Rahel Frick, Simon P Kelow, Joseph H Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D Khare, Roland L Dunbrack, Jeffrey J Gray, Zuben E Sauna
[This corrects the article DOI: 10.1016/j.heliyon.2023.e15032.].
August 2023: Heliyon
#19
JOURNAL ARTICLE
Vítor Borges, Mariana Perez Duque, João Vieira Martins, Paula Vasconcelos, Rita Ferreira, Daniel Sobral, Ana Pelerito, Isabel Lopes de Carvalho, Maria Sofia Núncio, Maria José Borrego, Cornelius Roemer, Richard A Neher, Megan O'Driscoll, Raquel Rocha, Sílvia Lopo, Raquel Neves, Paula Palminha, Luís Coelho, Alexandra Nunes, Joana Isidro, Miguel Pinto, João Dourado Santos, Verónica Mixão, Daniela Santos, Silvia Duarte, Luís Vieira, Fátima Martins, Jorge Machado, Vítor Cabral Veríssimo, Berta Grau, André Peralta-Santos, José Neves, Margarida Caldeira, Mafalda Pestana, Cândida Fernandes, João Caria, Raquel Pinto, Diana Póvoas, Fernando Maltez, Ana Isabel Sá, Mafalda Brito Salvador, Eugénio Teófilo, Miguel Rocha, Virginia Moneti, Luis Miguel Duque, Francisco Ferreira E Silva, Teresa Baptista, Joana Vasconcelos, Sara Casanova, Kamal Mansinho, João Vaz Alves, João Alves, António Silva, Miguel Alpalhão, Cláudia Brazão, Diogo Sousa, Paulo Filipe, Patrícia Pacheco, Francesca Peruzzu, Rita Patrocínio de Jesus, Luís Ferreira, Josefina Mendez, Sofia Jordão, Frederico Duarte, Maria João Gonçalves, Eduarda Pena, Claúdio Nunes Silva, André Rodrigues Guimarães, Margarida Tavares, Graça Freitas, Rita Cordeiro, João Paulo Gomes
Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal...
September 11, 2023: Nature Medicine
#20
RANDOMIZED CONTROLLED TRIAL
Amélie Debray, Hugo Gravel, Laurence Garceau, Audrey-Ann Bartlett, Georgia K Chaseling, Hadiatou Barry, Parya Behzadi, Nicholas Ravanelli, Josep Iglesies-Grau, Anil Nigam, Martin Juneau, Daniel Gagnon
Regular Finnish sauna use is associated with a reduced risk of cardiovascular mortality. However, physiological mechanisms underlying this association remain unknown. This study determined if an 8-wk Finnish sauna intervention improves peripheral endothelial function, microvascular function, central arterial stiffness, and blood pressure in adults with coronary artery disease (CAD). Forty-one adults (62 ± 6 yr, 33 men/8 women) with stable CAD were randomized to 8 wk of Finnish sauna use ( n = 21, 4 sessions/wk, 20-30 min/session, 79°C, 13% relative humidity) or a control intervention ( n = 20, lifestyle maintenance)...
October 1, 2023: Journal of Applied Physiology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
