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https://www.readbyqxmd.com/read/28934817/aldosterone-to-renin-ratio-as-a-screening-instrument-for-primary-aldosteronism-in-a-middle-aged-population-with-atrial-fibrillation
#1
Georgios Mourtzinis, Ahmad Ebrahimi, Helena Gustafsson, Gudmundur Johannsson, Karin Manhem
Atrial fibrillation seems to be overrepresented among patients with primary aldosteronism. The aim of this study was to determine the usefulness of aldosterone to renin ratio as a screening instrument for primary aldosteronism in an atrial fibrillation population with relatively low cardiovascular risk profile. A total of 149 patients <65 years and with history of AF were screened for primary aldosteronism using aldosterone to renin ratio. Pathologically increased aldosterone to renin ratio (>65 pmol/mIU) was found in 15 participants (10...
September 21, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28934779/what-are-the-predictors-of-altered-central-pain-modulation-in-chronic-musculoskeletal-pain-populations-a-systematic-review
#2
Jacqui Clark, Jo Nijs, Gillian Yeowell, Peter Charles Goodwin
BACKGROUND: Altered central pain modulation is the predominant pain mechanism in a proportion of chronic musculoskeletal pain disorders and is associated with poor outcomes. Although existing studies predict poor outcomes such as persistent pain and disability, to date there is little consensus on what factors specifically predict altered central pain modulation. OBJECTIVES: To review the existing literature on the predictive factors specifically for altered central pain modulation in musculoskeletal pain populations...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934726/application-of-adverse-outcome-pathways-to-u-s-epa-s-endocrine-disruptor-screening-program
#3
REVIEW
Patience Browne, Pamela D Noyes, Warren M Casey, David J Dix
BACKGROUND: The U.S. EPA's Endocrine Disruptor Screening Program (EDSP) screens and tests environmental chemicals for potential effects in estrogen, androgen, and thyroid hormone pathways, and it is one of the only regulatory programs designed around chemical mode of action. OBJECTIVES: This review describes the EDSP's use of adverse outcome pathway (AOP) and toxicity pathway frameworks to organize and integrate diverse biological data for evaluating the endocrine activity of chemicals...
September 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934711/alterations-of-larval-photo-dependent-swimming-responses-pdr-new-endpoints-for-rapid-and-diagnostic-screening-of-aquatic-contamination
#4
Luis Colón-Cruz, Lauren Kristofco, Jonathan Crooke-Rosado, Agnes Acevedo, Aranza Torrado, Bryan W Brooks, María A Sosa, Martine Behra
Detection and toxicity assessment of waterborne contaminants are crucial for protecting human health and the environment. Development of easy-to-implement, rapid and cost-effective tools to measure anthropogenic effects on watersheds are critical for responsible management, particularly in times of increasing development and urbanization. Traditionally, environmental toxicology has focused on limited endpoints, such as lethality and fertility, which are directly affecting population levels. However, more sensitive readings are needed to assess sub-lethal effects...
September 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28934434/high-sensitivity-assays-for-plasmodium-falciparum-infection-by-immuno-polymerase-chain-reaction-detection-of-pfideh-and-pfldh-antigens
#5
Jianbing Mu, John F Andersen, Jesus G Valenzuela, Thomas E Wellems
Background: Rapid diagnostic tests based on Plasmodium falciparum histidine-rich protein II (PfHRP-II) and P. falciparum lactate dehydrogenase (PfLDH) antigens are widely deployed for detection of P. falciparum infection; however, these tests often miss cases of low-level parasitemia, and PfHRP-II tests can give false-negative results when P. falciparum strains do not express this antigen. Methods: We screened proteomic data for highly expressed P. falciparum proteins and compared their features to those of PfHRP-II and PfLDH biomarkers...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934280/recurrent-deletions-of-the-x-chromosome-linked-cnv64-cnv67-and-cnv69-shows-geographic-differences-across-china-and-no-association-with-idiopathic-infertility-in-men
#6
Xiulan Ma, Martin Kuete, Xiuli Gu, Hui Zhou, Chengliang Xiong, Honggang Li
A recent study found that three recurrent deletions of X chromosome linked copy number variations (CNVs), CNV64, CNV67 and CNV69 were associated with idiopathic male infertility in Spanish and Italian populations, especially CNV67 resembling the azoospermia factor deletions. That merits further investigations among different populations. This study was conducted to examine the prevalence of the three CNVs deletions and their associations with idiopathic male infertility in Chinese Han population. The present study included a large population of 1550 Chinese Han subjects recruited between 2014 and 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28934228/knowledge-about-tuberculosis-transmission-and-prevention-and-perceptions-of-health-service-utilization-among-index-cases-and-contacts-in-brazil-understanding-losses-in-the-latent-tuberculosis-cascade-of-care
#7
Flavia Matos Salame, Márcia Danielle Ferreira, Marcia Teresa Belo, Eleny Guimarães Teixeira, Marcelo Cordeiro-Santos, Ricardo Arraes Ximenes, Maria de Fátima Militão de Albuquerque, Philip C Hill, Dick Menzies, Anete Trajman
INTRODUCTION: Tuberculosis contacts are candidates for active and latent tuberculosis infection screening and eventual treatment. However, many losses occur in the different steps of the contacts' cascade of care. Reasons for this are poorly understood. OBJECTIVE: To describe the different steps where losses in the contact cascade occur and to explore knowledge and attitudes regarding tuberculosis transmission/prevention and perceptions about tuberculosis services in order to understand the reasons for losses from the tuberculosis service users' perspective...
2017: PloS One
https://www.readbyqxmd.com/read/28934192/metabolomics-and-cognition-in-african-american-adults-in-midlife-the-atherosclerosis-risk-in-communities-study
#8
J Bressler, B Yu, T H Mosley, D S Knopman, R F Gottesman, A Alonso, A R Sharrett, L M Wruck, E Boerwinkle
Clinical studies have shown alterations in metabolic profiles when patients with mild cognitive impairment and Alzheimer's disease dementia were compared to cognitively normal subjects. Associations between 204 serum metabolites measured at baseline (1987-1989) and cognitive change were investigated in 1035 middle-aged community-dwelling African American participants in the biracial Atherosclerosis Risk in Communities (ARIC) Study. Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), the Digit Symbol Substitution Test (DSST; processing speed) and the Word Fluency Test (WFT; verbal fluency) at visits 2 (1990-1992) and 4 (1996-1998)...
July 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28934183/trends-in-cervical-cancer-screening-in-title-x-funded-health-centers-united-states-2005-2015
#9
Christina I Fowler, Mona Saraiya, Susan B Moskosky, Jacqueline W Miller, Julia Gable, Nancy Mautone-Smith
Cervical cancer screening is critical to early detection and treatment of precancerous cells and cervical cancer. In 2015, 83% of U.S. women reported being screened per current recommendations, which is below the Healthy People 2020 target of 93% (1,2). Disparities in screening persist for women who are younger (aged 21-30 years), have lower income, are less educated, are uninsured, lack a source of health care, or who self-identify as Asian or American Indian/Alaska Native (2). Women who are never screened or rarely screened are more likely to develop cancer and receive a cancer diagnosis at later stages than women who are screened regularly (3)...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934151/natural-history-of-hpv-infection-across-the-lifespan-role-of-viral-latency
#10
REVIEW
Patti E Gravitt, Rachel L Winer
Large-scale epidemiologic studies have been invaluable for elaboration of the causal relationship between persistent detection of genital human papillomavirus (HPV) infection and the development of invasive cervical cancer. However, these studies provide limited data to adequately inform models of the individual-level natural history of HPV infection over the course of a lifetime, and particularly ignore the biological distinction between HPV-negative tests and lack of infection (i.e., the possibility of latent, undetectable HPV infection)...
September 21, 2017: Viruses
https://www.readbyqxmd.com/read/28934088/accuracy-of-a-rapid-intrapartum-group%C3%A2-b-streptococcus-test-a-new-immunochromatographic-assay
#11
A Delabaere, S Curinier, S Ughetto, L Gibold, R Bonnet, A Rossi, D Gallot
OBJECTIVES: To decrease the incidence of early-onset group B streptococcal (GBS) disease, a culture-based screening of all pregnant women at 35-37 weeks is recommended. This gold standard test requires 24-72hours culture. This delay precludes its use for intrapartum screening. This study assesses a new immunoassay, the DIMA test, for identifying GBS-positive patients in the labor ward. MATERIALS AND METHODS: This was a prospective observational study of 195 pregnant women presenting with full-term labor at a single site in France between June and August 2012...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28933963/delayed-sample-arrival-at-the-laboratory-does-not-lead-to-more-false-negatives-in-the-danish-population-screening-for-colorectal-cancer
#12
Anette Tarp Hansen, Elke Hoffmann-Lücke, Betina Klint Nielsen, Birgitte Reinholdt, Peter Hindersson, Karin Heidemann, Nete Hornung
In Denmark, biennial population screening for colorectal cancer was introduced in 2014 for all aged 50-74 years. Five laboratories representative for the regional division of Denmark perform the immunochemical testing of faecal occult blood in the screening samples (iFOBT, OC-Sensor (Eiken Chemical, cut-off 100 µg/L)). In July 2016, a new agreement on the public post-delivery entailed an increased lag time (five days) from the screening participant drops the screening sample into a mail-box until sample arrival at the laboratories...
September 21, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28933956/relationship-between-reading-and-long-term-storage-and-retrieval-glr-in-college-students
#13
Maria Jesus Avitia, Alan S Kaufman, Melissa Bray, James C Kaufman
The purpose of this study was to (a) identify the relationship between specific types of reading ability, different forms of learning, and long-term memory and retrieval (Glr); and then (b) to determine the degree to which self-assessed reading ability and a Glr measure could predict objective reading ability. College students were administered three different reading assessments from the Kaufman Test of Educational Achievement, Second Edition (KTEA-II): word reading, reading comprehension, and nonsense word decoding...
September 21, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28933929/diagnostic-accuracy-of-two-food-insecurity-screeners-recommended-for-use-in-health-care-settings
#14
Jennifer A Makelarski, Emily Abramsohn, Jasmine H Benjamin, Senxi Du, Stacy Tessler Lindau
OBJECTIVES: To test the diagnostic accuracy of the American Academy of Pediatrics (AAP) recommended food insecurity screener. METHODS: We conducted prospective diagnostic accuracy studies between July and November 2016 in Chicago, Illinois. We recruited convenience samples of adults from adult and pediatric emergency departments (12-month recall study: n = 188; 30-day recall study: n = 154). A self-administered survey included the 6-item Household Food Security Screen (gold standard), the validated 2-item Hunger Vital Sign (HVS; often, sometimes, never response categories), and the 2-item AAP tool (yes-or-no response categories)...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933746/evaluation-of-novel-dual-acetyl-and-butyrylcholinesterase-inhibitors-as-potential-anti-alzheimer-s-disease-agents-using-pharmacophore-3d-qsar-and-molecular-docking-approaches
#15
Xiaocong Pang, Hui Fu, Shilun Yang, Lin Wang, Ai-Lin Liu, Song Wu, Guan-Hua Du
DL0410, containing biphenyl and piperidine skeletons, was identified as an acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor through high-throughput screening assays, and further studies affirmed its efficacy and safety for Alzheimer's disease treatment. In our study, a series of novel DL0410 derivatives were evaluated for inhibitory activities towards AChE and BuChE. Among these derivatives, compounds 6-1 and 7-6 showed stronger AChE and BuChE inhibitory activities than DL0410. Then, pharmacophore modeling and three-dimensional quantitative structure activity relationship (3D-QSAR) models were performed...
July 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28933684/screening-of-primary-gp120-immunogens-to-formulate-the-next-generation-polyvalent-dna-prime-protein-boost-hiv-1-vaccines
#16
Shixia Wang, Te-Hui Wu, Anthony Hackett, Veronica Efros, Yan Wang, Dong Han, Aaron Wallace, Yuxin Chen, Guangnan Hu, Shuying Liu, Paul Clapham, James Arthos, David Montefiori, Shan Lu
Our previous preclinical studies and a Phase I clinical trial DP6-001 have indicated that a polyvalent Env formulation was able to elicit broadly reactive antibody responses including low titer neutralizing antibody responses against viral isolates of subtypes A, B, C and AE. In the current report, a panel of 62 gp120 immunogens were screened in a rabbit model to identify gp120 immunogens that can elicit improved binding and neutralizing antibody responses and some of them can be included in the next polyvalent formulation...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933670/on-enrichment-strategies-for-biomarker-stratified-clinical-trials
#17
Xiaofei Wang, Jingzhu Zhou, Ting Wang, Stephen L George
In the era of precision medicine, drugs are increasingly developed to target subgroups of patients with certain biomarkers. In large all-comer trials using a biomarker stratified design (BSD), the cost of treating and following patients for clinical outcomes may be prohibitive. With a fixed number of randomized patients, the efficiency of testing certain treatments parameters, including the treatment effect among biomarker positive patients and the interaction between treatment and biomarker, can be improved by increasing the proportion of biomarker positives on study, especially when the prevalence rate of biomarker positives is low in the underlying patient population...
September 21, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28933667/diagnostic-performance-of-cheeks-appearance-in-sleep-apnea
#18
Aline Prikladnicki, Denis Martinez, Melissa Giacomelli Brunetto, Cintia Zappe Fiori, Maria do Carmo Sfreddo Lenz, Erissandra Gomes
OBJECTIVE: Obstructive sleep apnea (OSA) is a common, potentially life-threatening, but underdiagnosed condition. The study aimed to test the role of facial myofunctional alterations in OSA screening. METHOD: Sixty-one individuals with sleep complaints were evaluated by the Orofacial Myofunctional Evaluation with Scores (OMES) protocol before undergoing polysomnography. The performance of each of the protocol scores in OSA screening was tested. RESULTS: The nonparametric correlation of the apnea-hypopnea index (AHI) was significant for 18 of the 41 variables of the OMES protocol...
September 21, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28933311/mg17-a-novel-triazole-derivative-abrogated-neuroinflammation-and-related-neurodegenerative-symptoms-in-rodents
#19
Gangadhar Matharasala, Ganesh Samala, Yogeeswari Perumal
The objective of present study is to explore multiple effects of the compound MG17 and relate them to achieve better therapeutic potential against neuroinflammation related disorders. We examined whether our compound is acting through regulating neuroinflammatory mediators. We have done some preliminary behavioral studies to shortlist the derivatives using rodent models of peripheral nerve injury in our earlier publication and now we extended our screening studies to explore the test compounds efficacy on other related peripheral neurological disorders such as Streptozotocin-induced diabetic peripheral neuropathy (DPN) and methyl mercury (MeHg) induced neurodegeneration in rats...
September 19, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28933241/characterization-of-human-s-adenosyl-homocysteine-hydrolase-in-vitro-and-identification-of-its-potential-inhibitors
#20
Weiwei Hao, Yanhua Li, Qiuli Shan, Tian Han, Wencheng Li, Sheng He, Kongkai Zhu, Yumei Li, Xiaojun Tan, Jinsong Gu
Human S-adenosyl-homocysteine hydrolase (SAHH, E.C.3.3.1.1) has been considered to be an attractive target for the design of medicines to treat human disease, because of its important role in regulating biological methylation reactions to catalyse the reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine (Ado) and l-homocysteine (Hcy). In this study, SAHH protein was successfully cloned and purified with optimized, Pichia pastoris (P. pastoris) expression system. The biological activity results revealed that, among the tested compounds screened by ChemMapper and SciFinder Scholar, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenol (coniferyl alcohol, CAS: 458-35-5, ZINC: 12359045) exhibited the highest inhibition against rSAHH (IC50= 34 nM)...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
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