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Julfikar Ali Junejo, Mithun Rudrapal, Lalit Mohan Nainwal, Kamaruz Zaman
BACKGROUND: Despite the availability of synthetic antidiabetic drugs, diabetes mellitus is still affecting millions of people with increasing rate of disease incidence and mortality throughout the world. Ethnomedicinal survey documents the traditional usefulness of Callicarpa arborea Roxb. stem bark in the management of diabetes mellitus. MATERIALS AND METHODS: In our study, hydro-alcoholic extract (HAE) of Callicarpa arborea stem bark was prepared according to WHO guidelines for herbal drugs, and screened for antidiabetic activity in streptozotocin (STZ)-induced diabetic rats...
August 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Muhammad Taha, Muhammad Tariq Javid, Syahrul Imran, Manikandan Selvaraj, Sridevi Chigurupati, Hayat Ullah, Fazal Rahim, Fahad Khan, Jahidul Islam Mohammad, Khalid Mohammed Khan
α-Amylase is a target for type-2 diabetes mellitus treatment. However, small molecule inhibitors of α-amylase are currently scarce. In the course of developing small molecule α-amylase inhibitors, we designed and synthesized thiadiazole quinoline analogs (1-30), characterized by different spectroscopic techniques such as (1)HNMR and EI-MS and screened for α-amylase inhibitory potential. Thirteen analogs 1, 2, 3, 4, 5, 6, 22, 23, 25, 26, 27, 28 and 30 showed outstanding α-amylase inhibitory potential with IC50 values ranges between 0...
August 12, 2017: Bioorganic Chemistry
M M Zacche, I Giarenis, G Thiagamoorthy, D Robinson, L Cardozo
OBJECTIVE: The aim of our study was to determine whether there is a link between aspects of the metabolic syndrome (MetS) and overactive bladder (OAB) in women with lower urinary tract symptoms (LUTS). STUDY DESIGN: A single-centre prospective study. We evaluated a cohort of consecutive women with LUTS attending a tertiary referral urodynamic clinic from October 2012 to January 2015. Obesity, diabetes, hypertension and dyslipidaemia were used as markers of MetS...
August 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Karren-Lee Raymond, Lee Kannis-Dymand, Geoff P Lovell
AIMS: To examine differences in depression, anxiety, and stress across people with type 2 diabetes mellitus (t2d) classified according to a four level processed food addiction (PFA) severity indicator dichotomy. METHODS: Four hundred and eight participants with a t2d diagnoses completed an online survey including the Yale Food Addiction Scale (YFAS) and the DASS-21. Based on YFAS symptom counts participants were classified as either: non-PFA; mild-PFA; moderate-PFA; or severe-PFA...
July 29, 2017: Diabetes Research and Clinical Practice
Jinhong Guo
We report a smartphone-powered medical dongle as a miniaturized electrochemical analyzer associated with an enzymatically beta-hydroxybutyrate test strip for accurate characterization of blood ketone in peripheral whole blood at the point of care, which is capable of providing critical guidance for the evaluation and treatment of Diabetic ketoacidosis (DK) and diabetic ketosis acid (DKA). The measured results of blood ketone by medical dongle were compared with the clinical results from a bulky biochemical analyzer with good agreement...
August 21, 2017: Analytical Chemistry
Rachel R Comito, Lynette A Badu, Nicholas Forcello
Directed immunotherapy at the programmed cell death-1 receptor has demonstrated efficacy in non-small-cell lung cancer, metastatic melanoma, and various other malignancies. Immune checkpoint inhibitors are innovative therapies producing some impressive clinical responses with a more manageable adverse effect profile when compared to traditional chemotherapy. The more common adverse effects associated with these agents include fatigue, rash, myalgia, pyrexia, and cough, but less common yet serious adverse effects have included immune-mediated colitis, pneumonitis, hepatitis, type 1 diabetes, and encephalitis...
January 1, 2017: Journal of Oncology Pharmacy Practice
Russell D Hamilton, Cory E Shield, David Laughrun
We looked retrospectively at the 3- to 5-year progression of mild, asymptomatic carotid artery stenosis (CAS). A random sample of 600 patients who had undergone at least two carotid artery duplex ultrasounds between 31 October 2006 and 1 November 2016 with a second duplex ⩾3 and ⩽5 years following the initial one were screened for inclusion. Internal carotid arteries (ICAs) were included if they had 20-49% stenosis on the initial duplex, with 440 carotid arteries meeting this criteria. Analyses were performed utilizing chi-squared and two-tailed t-tests...
August 1, 2017: Vascular Medicine
Viktor V Dremin, Evgeny A Zherebtsov, Victor V Sidorov, Alexander I Krupatkin, Irina N Makovik, Angelina I Zherebtsova, Elena V Zharkikh, Elena V Potapova, Andrey V Dunaev, Alexander A Doronin, Alexander V Bykov, Ilya E Rafailov, Karina S Litvinova, Sergei G Sokolovski, Edik U Rafailov
According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus...
August 2017: Journal of Biomedical Optics
María Sanz-Almazán, Teresa Montero-Carretero, Susana Sánchez-Ramón, M ª Teresa García Noain, Cristina Crespo-Soto
OBJECTIVES: To analyze the characteristics of acute diabetic complications attended in a hospital emergency department. MATERIAL AND METHODS: Cross-sectional, descriptive, retrospective study of patients with hyper- and hypoglycemic emergencies attended in a tertiary-care university hospital emergency department. RESULTS: We included 237 patients with a mean (SD) age of 61 (26) years. Diabetes had been diagnosed previously in 86.5% (type 2 in 74% and type 1 in 26%)...
July 2017: Emergencias
Lingning Huang, Liyong Yang, Peiwen Wu, Xiaofang Yan, Li Luo, Sunjie Yan
Recent studies have correlated cognitive function with albuminuria. We investigated the association between low-grade albuminuria and cognitive performance in nondemented elderly with type 2 diabetes in Fuzhou, China. Between January, 2013 and December, 2014, a retrospective study was performed in 815 patients with type 2 diabetes (398 female and 417 male patients), ages ≥60 years, with normal urinary albumin to creatinine ratios (UACR <30 mg/g). Patients were stratified into tertiles based on UACR levels (lowest tertile, UACR <5...
August 19, 2017: Metabolic Brain Disease
M A Minetto, G Motta, N E Gorji, D Lucini, G Biolo, F Pigozzi, P Portincasa, N A Maffiuletti
PURPOSE: Aims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population. METHODS: Ninety patients affected by obesity (N = 39), type 2 diabetes mellitus (N = 26) or both (N = 25) were recruited. They were asked to maintain their usual physical activity habits during two consecutive weeks and to fill the questionnaires twice (at the end of each week)...
August 19, 2017: Journal of Endocrinological Investigation
Trudy Voortman, Jessica C Kiefte-de Jong, M Arfan Ikram, Bruno H Stricker, Frank J A van Rooij, Lies Lahousse, Henning Tiemeier, Guy G Brusselle, Oscar H Franco, Josje D Schoufour
We aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. We studied 9701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45 years and over [median 64.1 years (95%-range 49.0-82.8)]. Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200 g/day), fruit (≥200 g/day), whole-grains (≥90 g/day), legumes (≥135 g/week), nuts (≥15 g/day), dairy (≥350 g/day), fish (≥100 g/week), tea (≥450 mL/day), ratio whole-grains:total grains (≥50%), ratio unsaturated fats and oils:total fats (≥50%), red and processed meat (<300 g/week), sugar-containing beverages (≤150 mL/day), alcohol (≤10 g/day) and salt (≤6 g/day)...
August 19, 2017: European Journal of Epidemiology
Zheng Zhang, Shenwei Zhang, Yong Wang, Ming Yang, Ning Zhang, Zhitao Jin, Liping Ding, Wei Jiang, Junke Yang, Zhimin Sun, Chunguang Qiu, Taohong Hu
Cardiac microvascular endothelial cells (CMECs) dysfunction is an important pathophysiological event in the cardiovascular complications induced by diabetes. However, the underlying mechanism is not fully clarified. Autophagy is involved in programmed cell death. Here we investigated the potential role of autophagy on the CMECs injury induced by high glucose. CMECs were cultured in normal or high glucose medium for 6, 12 and 24 h respectively. The autophagy of CMECs was measured by green fluorescence protein (GFP)-LC3 plasmid transfection...
August 20, 2017: Apoptosis: An International Journal on Programmed Cell Death
Hiroshi Hidaka, Daiki Ozawa, Shinichi Kuriyama, Taku Obara, Toru Nakano, Risako Kakuta, Kazuhiro Nomura, Kenichi Watanabe, Yukio Katori
Although clinical outcomes of descending necrotizing mediastinitis (DNM) and/or deep neck infection (DNI) have been extensively reported, no study has addressed delay in recovering oral ingestion after surgical interventions other than sporadic case reports. We herein compared clinical features of DNM and DNI cases over the same period, and clarified precipitating factors of delay in recovering oral ingestion by logistic regression analysis. We reviewed records of patients with DNI and DNM at our institution from August 2005 to July 2015...
August 20, 2017: European Archives of Oto-rhino-laryngology
Jing Wang, Jin Wang, Juan-Juan Wang, Wei-Fang Zhang, Xiang-Ying Jiao
Thioredoxin (Trx) interacting protein (TXNIP) is a Trx-binding protein that inhibits the antioxidative function of Trx and is highly expressed in the serum and tissue samples from diabetes patients. This study was to explore whether TXNIP overexpression could cause INS-1 cell autophagy under normal glucose and lipid concentrations, and to analyze the role of autophagy in the apoptosis of INS-1 cells. The INS-1 cells cultured under normal conditions were divided into three groups: normal control, empty adenovirus vector (Ad-eGFP) and TXNIP overexpression (Ad-TXNIP-eGFP) groups...
August 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Shashank Shekhar, Shaoxun Wang, Paige N Mims, Ezekiel Gonzalez-Fernandez, Chao Zhang, Xiaochen He, Catherine Y Liu, Wenshan Lv, Yangang Wang, Juebin Huang, Fan Fan
Alzheimer's disease (AD) is the leading cause of progressive degenerative dementia. The hallmark pathological features include beta amyloid deposition and neurofibrillary tangles. There has been a strong association of AD with Diabetes (DM) based on human studies and animal experiments. The hallmark features of AD seem to have an exaggerated presence in AD with DM, especially type 2 diabetes (T2D). In addition, insulin resistance is a common feature in both diseases and as such AD has been called type 3 diabetes...
June 2017: Curr Res Diabetes Obes J
Katherine M Nowotny, Richard G Rogers, Jason D Boardman
This paper compares black-white health disparities among state prisoners to disparities in the noninstitutionalized community to provide a more complete portrait of the nation's heath. We use data from the 2004 Survey of Inmates in State and Federal Correctional Facilities and the 2002 and 2004 National Health and Nutrition Examination Survey for incarcerated and noninstitutionalized adult (aged 18 to 65) men and women, respectively. Health disparities between black and white male prisoners based on self-reported prevalence are similar to disparities in the general population for hypertension and diabetes but significantly reduced for kidney problems and stroke...
December 2017: SSM—Population Health
Adnan Sultan, Yuting Zheng, Patrick J Trainor, Yong Siow, Alok R Amraotkar, Bradford G Hill, Andrew P DeFilippis
BACKGROUND: Collagen is a major determinant of atherosclerotic plaque stability. Thus, identification of differences in enzymes that regulate collagen integrity could be useful for predicting susceptibility to atherothrombosis or for diagnosing plaque rupture. In this study, we sought to determine whether prolidase, the rate-limiting enzyme of collagen turnover, differs in human subjects with acute myocardial infarction (MI) versus those with stable coronary artery disease (CAD). METHODS: We measured serum prolidase activity in 15 patients with stable CAD and 49 patients with acute MI, of which a subset had clearly defined thrombotic MI (n = 22) or non-thrombotic MI (n = 12)...
2017: Frontiers in Cardiovascular Medicine
Valeria Ludovici, Jens Barthelmes, Matthias P Nägele, Frank Enseleit, Claudio Ferri, Andreas J Flammer, Frank Ruschitzka, Isabella Sudano
Cardiovascular disease (CVD) represents the most common cause of death worldwide. The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke. Intervention studies strongly suggest that cocoa exerts a beneficial impact on cardiovascular health, through the reduction of blood pressure (BP), improvement of vascular function, modulation of lipid and glucose metabolism, and reduction of platelet aggregation. These potentially beneficial effects have been shown in healthy subjects as well as in patients with risk factors (arterial hypertension, diabetes, and smoking) or established CVD (coronary heart disease or heart failure)...
2017: Frontiers in Nutrition
Justin M Oldham, Harold R Collard
Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial pneumonia of unknown etiology, primarily affects older adults and leads to a progressive decline in lung function and quality of life. With a median survival of 3-5 years, IPF is the most common and deadly of the idiopathic interstitial pneumonias. Despite the poor survivorship, there exists substantial variation in disease progression, making accurate prognostication difficult. Lung transplantation remains the sole curative intervention in IPF, but two anti-fibrotic therapies were recently shown to slow pulmonary function decline and are now approved for the treatment of IPF in many countries around the world...
2017: Frontiers in Medicine
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