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https://www.readbyqxmd.com/read/30243239/rational-design-and-synthesis-of-new-tetralin-sulfonamide-derivatives-as-potent-anti-diabetics-and-dpp-4-inhibitors-2d-3d-qsar-in-vivo-radiolabeling-and-bio-distribution-studies
#1
Somaia S Abd El-Karim, Manal M Anwar, Yasmin M Syam, Manal A Nael, Hanan F Ali, Mohamed A Motaleb
Type 2 diabetes (T2D) is a severe disease and it is one of the most raising problems worldwide. This study deals with design, synthesis and in vivo determination of a new set of tetralin-sulfonamide derivatives as anti-diabetic and dipeptidyl peptidase-IV (DPP-4) inhibiting agents. Most of the new compounds exhibited significant hypoglycemic effect alongside with DPP-4 suppression potency considering sitagliptin as a reference drug. The most promising compounds 4, 15 showed 2.80 nM DPP-4 IC50 with 20-40 folds selectivity over DPP-8 and DPP-9...
September 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/30243190/ambient-fine-particulate-pollution-associated-with-diabetes-mellitus-among-the-elderly-aged-50-years-and-older-in-china
#2
Yin Yang, Yanfei Guo, Zhengmin Min Qian, Zengliang Ruan, Yang Zheng, Alistair Woodward, Siqi Ai, Steven W Howard, Michael G Vaughn, Wenjun Ma, Fan Wu, Hualiang Lin
The linkage between ambient air pollution exposure and occurrence of diabetes mellitus is not well defined. This study examined the association between exposure to fine particles (PM2.5 ) and the prevalence of diabetes among Chinese elderly people. We surveyed 11,504 adults aged ≥50 years in China, estimated the annual concentrations of ambient PM2.5 using a satellite-based model of aerosol optical depth information. We employed a generalized mixed effects model to examine the association between PM2.5 and the prevalence of diabetes and explored potential effect modifiers...
September 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30243187/prediction-of-hemorrhagic-transformation-in-patients-with-mild-atrial-fibrillation-associated-stroke-treated-with-early-anticoagulation-post-hoc-analysis-of-the-triple-axel-trial
#3
Sang Hun Lee, Keun-Sik Hong, Ji Sung Lee, Yong-Jae Kim, Tae-Jin Song, Young Dae Kim, Man-Seok Park, Eung-Gyu Kim, Jae-Kwan Cha, Sang Min Sung, Byung-Woo Yoon, Oh Young Bang, Woo-Keun Seo, Yang-Ha Hwang, Seong Hwan Ahn, Dong-Wha Kang, Hyun Goo Kang, Kyung-Ho Yu, Sun U Kwon
OBJECTIVES: To investigate the predictors of hemorrhagic transformation (HT) in patients with mild atrial fibrillation-related stroke who were treated with early anticoagulation. We conducted a post-hoc subgroup analysis from Acute Cerebral Infarction Patients with Non-valvular Atrial Fibrillation (Triple AXEL) study. PATIENTS AND METHODS: The Triple AXEL study was a randomized, multicenter, open-label, blinded end-point evaluation, comparative phase 2 trial. To identify the relationship between the type of HT and risk factors...
September 9, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30243182/the-role-of-oxidative-stress-in-cardiometabolic-risk-related-to-phthalate-exposure-in-elderly-diabetic-patients-from-shanghai
#4
RuiHua Dong, JingSi Chen, JianHeng Zheng, MeiRu Zhang, Han Zhang, Min Wu, ShuGuang Li, Bo Chen
The effect of human exposure to phthalates and consequent contribution to the development of cardiometabolic health problems is unknown. However, oxidative stress has been established as playing an important role in the pathogenesis of cardiometabolic outcomes. In this study, we aimed to explore whether exposure to phthalate metabolites could induce cardiometabolic risk by increasing oxidative stress in a diabetic population from Shanghai. We collected paired blood and urine samples from a total of 300 volunteers, and measured 10 phthalate metabolites in urine and biomarkers of oxidative stress from serum including glucose and lipid levels, and liver and kidney damage...
September 19, 2018: Environment International
https://www.readbyqxmd.com/read/30243088/syringic-acid-sa-%C3%A2-a-review-of-its-occurrence-biosynthesis-pharmacological-and-industrial-importance
#5
REVIEW
Cheemanapalli Srinivasulu, Mopuri Ramgopal, Golla Ramanjaneyulu, C M Anuradha, Chitta Suresh Kumar
The use of phytochemicals in control of human diseases have been considerable public and scientific interest in current days. Syringic acid (SA), a phenolic compound often found in fruits and vegetables and which is synthesized via shikimic acid pathway in plants. It shows a wide range of therapeutic applications in prevention of diabetes, CVDs, cancer, cerebral ischemia; as well as it possess anti-oxidant, antimicrobial, anti-inflammatory, antiendotoxic, neuro and hepatoprotective activities. It has an effective free radical scavenger and alleviates the oxidative stress markers...
September 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30243011/the-adipokine-chemerin-and-fetuin-a-serum-levels-in-type-2-diabetes-mellitus-relation-to-obesity-and-inflammatory-markers
#6
Thorya S El-Deeb, Sally M Bakkar, Lobna Eltoony, Madeha M Zakhary, Amira A Kamel, Amany M Nafee, Helal F Hetta
Chemerin and fetuin-A are recently discovered as metabolic regulator hormone in obesity and type 2 diabetes mellitus. However, elevated levels of chemerin and fetuin-A have been associated with insulin resistance and systemic inflammation. The present study aimed to investigate the significance of serum chemerin and fetuin-A levels in obese diabetic patients. Also, to determine whether, chemerin and fetuin-A along with markers of inflammation (IL6 and CRP) and obesity-related parameters in T2DM patients. Serum levels of chemerin and fetuin-A were evaluated using ELISA in 71 T2DM patients and 14 apparently healthy controls...
January 2018: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/30243010/serum-levels-of-interleukins-1-alpha-12-as-predictors-of-disease-progression-in-hepatitis-c-diabetic-patients
#7
Mohammed Khalil, Omnia El-Badawy, Abeer Sharaf-Eldin, Ahmed Sadek, Ayman Sabry
This study evaluates the usefulness of interleukins 1 alpha and 12 in predicting disease progression in diabetic HCV and HCV related liver diseases compared to non-diabetics. The study included 76 hepatitis C virus-infected patients [38 diabetics, 38 none (with, without cirrhosis)]. Serum levels of IL-1α and IL-12 were measured by ELISA. Serum levels of IL-1α and IL12 were higher in cirrhotic than non -cirrhotic patients and higher in the diabetic patients. Significant correlations were detected between IL-1α, prothrombin time (PT), and severity scores in cirrhotic patients...
January 2018: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/30242999/frequency-of-circulating-b1a-and-b2-b-cell-subsets-in-egyptian-patients-with-type-2-diabetes-mellitus
#8
Reham H Hammad, Asmaa A El-Madbouly, Hend G Kotb, Mohammed S Zarad
Type 2 diabetes mellitus (T2DM) is a growing health problem in Egypt. T2DM is recognized as chronic inflammatory disease with involvement of immune cells including B cells. We aimed to determine the frequency of antibody secreting B1a and B2 B cells in T2DM patients, their correlation with diabetes metabolic parameters and whether they play a role in diabetic foot infection (DFI) development. This study included 56 participants, recruited from Al-Zahraa hospital, Al-Azhar University, Egypt. Of these, 36 patients were diagnosed with T2DM, divided to two groups; (1) DM group (n=19) recently diagnosed, without foot complication; (2) DFI group (n=17); in addition to a Control group (n=20)...
January 2018: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/30242998/association-of-stnfr1-and-bnp-levels-with-diminished-estimated-glomerular-filtration-rate-in-type-2-diabetic-egyptian-patients
#9
Entsar R Mokhtar, Eman M, Maha A Hassan, Hanaa A Abou-ELHassan, Mona G Alanany, Mohammed A Hasuna
Renal dysfunction is a key risk factor for all-cause mortality in patients with type 2 diabetes (T2D). Special attention has been raised regarding the role of soluble tumor necrosis factor receptor1 (sTNFR1) and brain natriuretic peptide (BNP) in diabetic nephropathy (DN) since they play a crucial role in the pathogenesis of T2D complications. Elevated concentrations of sTNFR1and BNP were found to be associated with progression to end stage renal disease (ESRD) in T2D. We determined serum levels of sTNFR1 and BNP in T2D patients and correlated them with various clinical variables especially kidney function and urinary albumin creatinine ratio (UACR)...
January 2018: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/30242962/nyx-2925-a-novel-n-methyl-d-aspartate-receptor-modulator-a-first-in-human-randomized-double-blind-study-of-safety-and-pharmacokinetics-in-adults
#10
David R Houck, Laurel Sindelar, Carlos R Sanabria, Stephanie H Stanworth, Maggie Krueger, Mary Suh, Torsten M Madsen
NYX-2925, a new chemical entity, acts as a co-agonist to glutamate at the N-methyl-D-aspartate receptor (NMDAR). At low concentrations of endogenous agonists (glycine/D-serine), NYX-2925 partially activates NMDARs, modulating neural pathways relevant for chronic pain. NYX-2925 is being developed for the treatment of chronic pain conditions, including painful diabetic peripheral neuropathy and fibromyalgia. In this first-in-human, Phase 1, single- (50-1200 mg) and multiple-ascending dose (150-900 mg) study, the safety, tolerability, and pharmacokinetics of NYX-2925 were evaluated in 84 healthy adult volunteers...
September 22, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/30242948/effect-of-liraglutide-on-ambulatory-blood-pressure-in-hypertensive-patients-with-type-2-diabetes-randomized-double-blind-placebo-controlled-trial
#11
Aris Liakos, Vaia Lambadiari, Alexandra Bargiota, Konstantinos Kitsios, Iakovos Avramidis, Kalliopi Kotsa, Spyridon Gerou, Panagiota Boura, Nikolaos Tentolouris, George Dimitriadis, Apostolos Tsapas
AIMS: To assess the effect of liraglutide on 24-h ambulatory blood pressure and heart rate in patients with hypertension (pre- and stage 1 hypertension) and inadequately controlled type 2 diabetes (hemoglobin A1c 7-10%). MATERIALS AND METHODS: Eligible patients for this investigator-initiated, parallel group, randomized, double blind trial were on stable background antihyperglycemic therapy excluding insulin, glucagon-like peptide 1 receptor agonists and dipeptidyl-peptidase 4 inhibitors...
September 22, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30242910/pregnancy-complications-treatment-characteristics-and-birth-outcomes-in-women-with-atopic-dermatitis-in-denmark
#12
Carsten R Hamann, Alexander Egeberg, Andreas Wollenberg, Gunnar Gislason, Lone Skov, Jacob P Thyssen
BACKGROUND: The risk of prenatal, obstetric and birth complications in mothers with atopic dermatitis (AD), along with treatment use during pregnancy, is unknown. OBJECTIVES: To examine the associations between prenatal, obstetric and birth complications in mothers with AD and describe the dermatologic care received during pregnancy. METHODS: Mother-child pairs, in which the mother had a history of AD, were identified through the Danish Medical Birth Registry and matched 1:10 with non-AD pairs...
September 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30242908/screening-for-peripheral-artery-disease-in-people-with-diabetes-authors-reply
#13
B Vriens, F D'Abate, B A Ozdemir, C Fenner, W Maynard, J Budge, D Carradice, R J Hinchliffe
We thank Hersant and colleagues for their interest in our work [1]. Our study was principally designed to address the utility of clinical examination and adjunctive tests to exclude peripheral artery disease (PAD) in people with diabetes-related foot ulceration. We emphasize the importance of a negative likelihood ratio (and sensitivity) throughout because a missed diagnosis has potentially more severe consequences. This article is protected by copyright. All rights reserved.
September 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30242901/physical-activity-is-associated-with-lower-insulin-and-c-peptide-during-glucose-challenge-in-children-and-adolescents-with-family-background-of-diabetes
#14
K Ungethüm, M Jolink, M Hippich, L Lachmann, F Haupt, C Winkler, S Hummel, A Pitchika, O Kordonouri, A-G Ziegler, A Beyerlein
AIMS: Children and adolescents with a family history of diabetes are at increased risk of overweight, but little is known about the potentially beneficial effects of physical activity on these children. The objective of this study was to investigate the association between moderate to vigorous physical activity (MVPA) and metabolic and inflammatory risks in children and adolescents with a family background of Type 1 diabetes or gestational diabetes. METHODS: Valid MVPA measurements, made with accelerometers, were available from 234 participants (median age, 10...
September 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30242898/estimates-of-age-specific-diabetes-incidence-among-men-and-women-in-china-using-secondary-data-analysis
#15
Y Jiang, W Ni
Affecting 9.5% of the population, diabetes represents a major health threat in China. Although age-specific incidence estimates are essential for the prevention and management of diabetes from the public health perspective and have been investigated among populations in several regions, there are no estimates for Chinese people in the literature. We therefore conducted a study to estimate the age-specific diabetes incidence among men and women in China using a secondary data analysis. This article is protected by copyright...
September 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30242891/stabilizing-proteins-to-prevent-conformational-changes-required-for-amyloid-fibril-formation
#16
Mohammad Khursheed Siddiqi, Parvez Alam, Sadia Malik, Nabeela Majid, Sumit Kumar Chaturvedi, Sudeepa Rajan, Mohd Rehan Ajmal, Mohsin Vahid Khan, Vladimir N Uversky, Rizwan Hasan Khan
Amyloid fibrillation is associated with several human maladies, such as Alzheimer's, Parkinson's, Huntington's diseases, prions, amyotrophic lateral sclerosis, and type 2 diabetes diseases. Gaining insights into the mechanism of amyloid fibril formation and exploring novel approaches to fibrillation inhibition are crucial for preventing amyloid diseases. Here, we hypothesized that ligands capable of stabilizing the native state of query proteins might prevent protein unfolding, which, in turn, may reduce the propensity of proteins to form amyloid fibrils...
September 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30242842/metformin-inhibits-ige-and-aryl-hydrocarbon-receptor-mediated-mast-cell-activation-in-vitro-and-in-vivo
#17
Hsueh-Chun Wang, Shau-Ku Huang
Metformin, an anti-diabetic drug, possesses anti-inflammatory property beyond its glucose-lowering activity, but its regulatory effect on mast cells and allergic responses remains unknown, wherein the aryl hydrocarbon receptor (AhR)-ligand axis is critical in controlling mast cell activation. Herein, we provide evidence supporting the role of metformin in modulating mast cell activation by FcεR1-, AhR-mediated signaling or their combination. Metformin at relatively low doses was shown to suppress FcεR1-mediated degranulation, IL-13, TNF-α and sphingosine-1-phosphate (S1P) secretion in murine bone marrow-derived mast cells (BMMCs)...
September 22, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/30242808/risk-factors-for-complications-and-graft-failure-in-kidney-transplant-patients-with-sepsis
#18
Syuan-Hao Syu, Yung-Wei Lin, Ke-Hsun Lin, Liang-Ming Lee, Chi-Hao Hsiao, Yu-Ching Wen
Immunosuppressive therapies decreased the incidence of acute kidney rejection after kidney transplantation, but also increased the risk of infections and sepsis. This study aimed to identify the risk factors associated with complications and/or graft failure in kidney transplant patients with sepsis. A total of 14,658 kidney transplant patients with sepsis, identified in the National Inpatient Sample (NIS) database (data from 2005-2014), were included in the study and classified into three groups: patients without complications or graft failure/dialysis (Group 1), patients with complications only (Group 2), and patients with complications and graft failure/dialysis (Group 3)...
September 16, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30242726/the-efficacy-and-safety-of-dipeptidyl-peptidase-4-inhibitors-for-type-2-diabetes-a-bayesian-network-meta-analysis-of-58-randomized-controlled-trials
#19
REVIEW
Juan Ling, Peng Cheng, Long Ge, Ding-Hua Zhang, An-Chen Shi, Jin-Hui Tian, Ya-Jing Chen, Xiu-Xia Li, Jing-Yun Zhang, Ke-Hu Yang
AIMS: The aim is to evaluate the efficacy and safety of dipeptidyl peptidase-4 inhibitors (DPP4-I: sitagliptin, saxagliptin, linagliptin, vildagliptin and alogliptin) in patients with type 2 diabetes. METHODS: We searched the Cochrane Library, PubMed, EMBASE, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), and the Wanfang Database from inception to April, 2018. Randomized controlled trials were included if they compared the different versions of DPP4-I with each other or with placebo in treatment of type 2 diabetes...
September 21, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/30242725/dietary-fat-and-risk-for-type-2-diabetes-a-review-of-recent-research
#20
REVIEW
Beth H Rice Bradley
PURPOSE OF REVIEW: It is estimated that over 400 million people worldwide are living with diabetes. Excess adiposity is the strongest risk factor for non-insulin-dependent diabetes, type 2. Lifestyle interventions have demonstrated that diet plays a critical role in preventing the onset of type 2 diabetes. Dietary fat is not only a source of energy and nutrients, but also bioactive fatty acids. The purpose of this review was to examine data from recent prospective cohort studies and dietary interventions to determine if there are benefits to fat consumption on diabetes risk...
September 21, 2018: Current Nutrition Reports
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