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https://www.readbyqxmd.com/read/29932300/potential-issues-with-complementary-medicines-commonly-used-in-the-cancer-population-a-retrospective-review-of-a-tertiary-cancer-center-s-experience
#1
Sally L Brooks, Gail Rowan, Michael Michael
AIM: Complementary medicine (CAM) use in the cancer population is higher than the general population: some studies estimate up to 70%. Our Medicines Information Centre, in a tertiary cancer institution, receives many enquiries regarding use and safety of CAM with conventional cancer therapies (chemotherapy, radiotherapy and surgery). This project aims to review the CAM most commonly enquired about with an emphasis on potential interactions with conventional cancer therapies. METHODS: An audit and review of CAM enquiries from patients or medical professionals at our center, over a 2-year period (July 2011-June 2013), was conducted...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931755/protein-components-of-water-extracts-from-fruiting-bodies-of-the-reishi-mushroom-ganoderma-lucidum-contribute-to-the-production-of-functional-molecules
#2
Kei Kumakura, Chiaki Hori, Hiroki Matsuoka, Kiyohiko Igarashi, Masahiro Samejima
BACKGROUND: Mushrooms have been widely considered as health foods as their extracts have anti-hypertensive and anti-tumor activities. After a thorough literature survey, we hypothesized that enzymes in mushroom extracts play an important role in synthesizing functional molecules. Therefore, in the present study, proteins extracted from Reishi mushroom (Ganoderma lucidum), which is used in oriental medicine, were identified by the proteomic approach, and appropriate extraction methods for improving angiotensin-converting enzyme (ACE) inhibitory activities were investigated...
June 22, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29931536/investigation-of-the-protective-effects-of-horse-mushroom-agaricus-arvensis-schaeff-against-carbon-tetrachloride-induced-oxidative-stress-in-rats
#3
Abdulahad Dogan, Abdullah Dalar, Cemil Sadullahoglu, Abdulhamit Battal, Yusuf Uzun, Ismail Celik, Kenan Demirel
Wild and cultured mushrooms have been extensively used for food and medicinal purposes all around the world. However, there is limited information on chemical composition, health enhancing effects and contributions on diet of some mushrooms (e.g., Agaricus arvensis) widely distributed in many countries including United Kingdom, Australia, Turkey etc. Therefore, the present study was aimed to analyse the bioactive composition and ameliorative effects of A. arvensis via evaluating in vitro and in vivo antioxidant properties in CCl4 induced rat model...
June 21, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29731920/association-of-iron-metabolic-enzyme-hepcidin-expression-levels-with-the-prognosis-of-patients-with-pancreatic-cancer
#4
Reishi Toshiyama, Masamitsu Konno, Hidetoshi Eguchi, Ayumu Asai, Takehiro Noda, Jun Koseki, Kei Asukai, Tomofumi Ohashi, Katsunori Matsushita, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, possibly through the generation of reactive oxygen species (ROS). Hepcidin, which is a peptide hormone mainly generated by the liver, inhibits iron absorption via enterocytes and iron release from macrophages...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29717669/novel-kombucha-beverage-from-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-with-antibacterial-and-antioxidant-effects
#5
Aleksandra Sknepnek, Milena Pantić, Danka Matijašević, Dunja Miletić, Steva Lević, Viktor Nedović, Miomir Niksic
Kombucha is a nonalcoholic beverage traditionally made by fermenting black tea using a combination of yeast and acetic acid bacteria (AAB) cultures. Ganoderma lucidum hot water extract (HWE) was used-to our knowledge for the first time-to prepare a novel, health-promoting kombucha product. During the 11-day fermentation, pH, total acidity, and the numbers of yeasts and AAB were monitored. It was found that sweetened G. lucidum HWE was a good medium for yeast and AAB growth. The desired acidity for the beverage was reached on the second day (3 g/L) of the fermentation process; the maximum established acidity was 22...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29691994/chemical-biochemical-preclinical-and-clinical-studies-of-ganoderma-lucidum-polysaccharide-as-an-approved-drug-for-treating-myopathy-and-other-diseases-in-china
#6
REVIEW
Pengjiao Zeng, Zhihua Guo, Xuan Zeng, Cui Hao, Yiran Zhang, Meng Zhang, Yong Liu, Hui Li, Juan Li, Lijuan Zhang
Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. It is a highly prized vitality-enhancing herb for more than 2000 years. G. lucidum polysaccharide (GLPS) has been identified as one of the major bioactive components and developed into a drug named "Ji 731 Injection" in China since 1973. The large-scale production of the drug began in 1985 and approved by the Chinese FDA as "Polysaccharidum of G. lucidum Karst Injection" (Ling Bao Duo Tang Zhu She Ye) in 2000, which is applied intramuscularly...
April 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29604916/determination-of-the-biological-efficiency-and-antioxidant-potential-of-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-cultivated-using-different-agro-wastes-in-malaysia
#7
Surya Sudheer, Ibrahim Alzorqi, Asgar Ali, Poh Guat Cheng, Yasmeen Siddiqui, Sivakumar Manickam
This study investigates the cultivation of Ganoderma lucidum using different agricultural biomasses from Malaysia. Five different combinations of rubber wood sawdust, empty fruit bunch fiber, and mesocarp fiber from oil palm, alone and in combination, were used to cultivate G. lucidum. Although all the substrate combinations worked well to grow the mushroom, the highest biological efficiency was obtained from the combination of empty fruit bunch fiber with sawdust. A total yield of 27% was obtained from empty fruit bunch fiber with sawdust, followed by sawdust (26%), empty fruit bunch fiber (19%), mesocarp fiber with sawdust (19%), and mesocarp fiber (16%)...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29534044/antitumour-antimicrobial-antioxidant-and-antiacetylcholinesterase-effect-of-ganoderma-lucidum-terpenoids-and-polysaccharides-a-review
#8
REVIEW
Darija Cör, Željko Knez, Maša Knez Hrnčič
Ganoderma lucidum (Reishi) is a popular medicinal mushroom and has been used in oriental medicine because of its promoting effects on health and life expectancy. G. lucidum contains various compounds with a high grade of biological activty, which increase the immunity and show antitumour, antimicrobial, anti-inflammatory, antioxidant and acetylcholinesterase inhibitory activity. Several of these substances belong to the triterpenoids and polysaccharides classes. Proteins, lipids, phenols, sterols, etc. are also present...
March 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29519314/hypotensive-and-neurometabolic-effects-of-intragastric-reishi-ganoderma-lucidum-administration-in-hypertensive-isiah-rat-strain
#9
Oleg B Shevelev, Alisa A Seryapina, Evgenii L Zavjalov, Lyudmila A Gerlinskaya, Tatiana N Goryachkovskaya, Nikolay M Slynko, Leonid V Kuibida, Sergey E Peltek, Arcady L Markel, Mikhail P Moshkin
BACKGROUND: As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin. PURPOSE: One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of many chronic diseases. STUDY DESIGN AND METHODS: To study the effectiveness of Reishi, which grows in the Altai Mountains, as an antihypertensive agent, we intragastrically administered Reishi water extract to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29457741/lucidumol-d-a-new-lanostane-type-triterpene-from-fruiting-bodies-of-reishi-ganoderma-lingzhi
#10
Dedi Satria, Yhiya Amen, Yasuharu Niwa, Ahmed Ashour, Ahmed E Allam, Kuniyoshi Shimizu
A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29421594/dna-damaging-potential-of-ganoderma-lucidum-extracts
#11
María Soledad Vela Gurovic, Fátima R Viceconte, Marcelo T Pereyra, Maximiliano A Bidegain, María Amelia Cubitto
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Lingzhi or Reishi) is a medicinal mushroom historically used in Asian countries to treat a wide variety of diseases and prolong life. In the last years, G. lucidum has been internationally recognized as an effective adjuvant in cancer treatment. Among active components, the most recent research indicates that polysaccharides modulate the immune response favoring the recovery from toxicity of chemo and radiotherapy while triterpenes are cytotoxic to tumoral cells mainly by altering gene expression...
May 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29399089/effects-of-ganoderic-acid-a-on-lipopolysaccharide-induced-proinflammatory-cytokine-release-from-primary-mouse-microglia-cultures
#12
Baojin Chi, Shuqiu Wang, Sheng Bi, Wenbo Qin, Dongmei Wu, Zhenguo Luo, Shiliang Gui, Dongwei Wang, Xingzhong Yin, Fangfang Wang
For several thousand years, Ganoderma lucidum (Ling-Zhi in Chinese and Reishi in Japanese) has been widely used as a traditional medication for the prevention and treatment of various diseases in Asia. Its major biologically active components, ganoderic acids (GAs), exhibit significant medicinal value due to their anti-inflammatory effects. Dysregulation of microglial function may cause seizures or promote epileptogenesis through release of proinflammatory cytokines, including interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29344411/emerging-roles-of-ganoderma-lucidum-in-anti-aging
#13
REVIEW
Jue Wang, Bin Cao, Haiping Zhao, Juan Feng
Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum , such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium of Ganoderma lucidum mycelia, Ganodermasides A, B, C, D, and some bioactive components of Ganoderma lucidum , including Reishi Polysaccharide Fraction 3, Ganoderma lucidum polysaccharides I, II, III, IV, Ganoderma lucidum peptide, Ganoderma polysaccharide peptide, total G...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29248453/reishi-mushroom-ganoderma-lucidum-modulates-iga-production-and-alpha-defensin-expression-in-the-rat-small-intestine
#14
Atsuhito Kubota, Masaki Kobayashi, Sota Sarashina, Reiko Takeno, Keisuke Okamoto, Katsuya Narumi, Ayako Furugen, Yuji Suzuki, Natsuko Takahashi, Ken Iseki
ETHNOPHARMACOLOGICAL RELEVANCE: Immunoglobulin A (IgA) secretion and alpha-defensins play a role in the innate immune system to protect against infection. Ganoderma lucidum (W.Curt.: Fr.) P. Karst. (Reishi) is a well-known mushroom in traditional Chinese medicine. This study aimed to determine the effects of Reishi on IgA secretion from Peyer's patch (PP) cells and alpha-defensin-5 (RD-5) and RD-6 expression in the rat small intestine. MATERIALS AND METHODS: The rats received an oral injection of 0...
March 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29199568/lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-inhibits-candida-biofilms-a-metabolomic-approach
#15
Anuja Bhardwaj, Payal Gupta, Navin Kumar, Jigni Mishra, Ajai Kumar, Rajput Rakhee, Kshipra Misra
This article presents a comparative gas chromatography (GC)-mass spectrometry (MS)-based metabolomic analysis of mycelia and fruiting bodies of the medicinal mushroom Ganoderma lucidum. Three aqueous extracts-mycelia, fruiting bodies, and a mixture of them-and their sequential fractions (methanolic and ethyl acetate), prepared using an accelerated solvent extractor, were characterized by GC-MS to determine volatile organic compounds and by high-performance thin-layer chromatography to quantify ascorbic acid, a potent antioxidant...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29105633/evaluation-of-antimicrobial-cytotoxic-and-genotoxic-activities-of-ganoderma-lucidum-reishi-mushroom
#16
Bulent Ergun
Ganoderma lucidum (GL) is a mushroom used as a traditional remedy for the treatment of various infections since ancient times. This study, was aimed to investigate antimicrobial activity potential of GL against Staphylococcus aureus, Enterococcus faecalis, Listeria monocytogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Candida glabrata, Candida krusei, and Candida parapsilopsis. Furthermore, it was also aimed to evaluate the toxicity potential of GL. Antimicrobial activities were screened by using microbroth dilution method...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28942945/polysaccharides-derived-from-ganoderma-lucidum-fungus-mycelia-ameliorate-indomethacin-induced-small-intestinal-injury-via-induction-of-gm-csf-from-macrophages
#17
Kenta Nagai, Yoshitaka Ueno, Shinji Tanaka, Ryohei Hayashi, Kei Shinagawa, Kazuaki Chayama
Non-steroidal anti-inflammatory drugs often cause ulcers in the human small intestine, but few effective agents exist to treat such injury. Ganoderma lucidum Karst, also known as "Reishi" or "Lingzhi", is a mushroom. We previously reported that a water-soluble extract from G. lucidum fungus mycelia (MAK) has anti-inflammatory effects in murine colitis induced by trinitrobenzene sulfonic acid, and induction of granulocyte macrophage colony-stimulating factor (GM-CSF) by MAK may provide anti-inflammatory effects...
October 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28845771/efficient-accumulation-and-in-vitro-antitumor-activities-of-triterpene-acids-from-submerged-batch-cultured-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes
#18
Xiao-Ling Wang, Zhong-Yang Ding, Yan Zhao, Gao-Qiang Liu, Guo-Ying Zhou
Triterpene acids are among the major bioactive constituents of lucidum. However, submerged fermentation techniques for isolating triterpene acids from G. lucidum have not been optimized for commercial use, and the antitumor activity of the mycelial triterpene acids needs to be further proven. The aim of this work was to optimize the conditions for G. lucidum culture with respect to triterpene acid production, scaling up the process, and examining the in vitro antitumor activity of mycelial triterpene acids...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28826695/natural-health-products-and-diabetes-a-practical-review
#19
REVIEW
Candace Necyk, Leyanna Zubach-Cassano
The prevalence of natural health product (NHP) use in Canada is extensive. Patients with chronic diseases, including diabetes, use NHPs at a higher rate than the general population. Many NHPs exert hypoglycemic effects, among other effects relevant to diabetes management. To provide a practical, clinical review of NHPs with such effects targeted to pharmacists, a literature search was performed to collect data on the efficacy and safety profiles of 10 commonly used NHPs that exert antidiabetic properties. The following NHPs are included in this clinical review: alpha-lipoic acid, chromium, magnesium, bitter melon, cinnamon, fenugreek, gymnema, milk thistle, Reishi mushroom and white mulberry...
December 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28798349/evaluation-on-quality-consistency-of-ganoderma-lucidum-dietary-supplements-collected-in-the-united-states
#20
Ding-Tao Wu, Yong Deng, Ling-Xiao Chen, Jing Zhao, Anton Bzhelyansky, Shao-Ping Li
Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form of dietary supplements in the United States due to its various benefits. However, the quality consistency of these products based on their label ingredients has seldom been evaluated due to the lack of a suitable toolkit. In this study, 19 batches of products of G. lucidum (Red Reishi, Reishi), herbal/mushroom supplements purchased in the United States, were evaluated based on their bioactive components including triterpenes and polysaccharides by using chromatographic methods and saccharide mapping...
August 10, 2017: Scientific Reports
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