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Renal papillary adenoma

X Wang, S S Shi, W R Yang, S B Ye, R Li, H H Ma, R S Zhang, Z F Lu, X J Zhou, Q Rao
Objective: To study the molecular features of metanephric adenoma (MA) and discuss their values in differential diagnosis. Methods: BRAF V600E immunohistochemistry (IHC) using the mutation-specific VE1 monoclonal antibody and Sanger sequencing of BRAF mutations were performed on 21 MAs, 16 epithelial-predominant Wilms tumors (e-WT) and 20 the solid variant of papillary renal cell carcinomas (s-PRCC) respectively. p16 protein was detected by IHC also. Fluorescence in situ hybridization (FISH) analyses using centromeric probes for chromosome 7 and 17 were performed on the three renal tumors in parallel...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
J Rübenthaler, K Paprottka, J Marcon, E Hameister, K Hoffmann, N Joiko, M Reiser, D A Clevert
PURPOSE: To compare the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) in the evaluation of unclear renal lesions to the histopathological outcome. MATERIALS AND METHODS: A total of 36 patients with a single unclear solid renal lesion with initial imaging studies between 2005 and 2015 were included. CEUS and MRI were used for determining malignancy or benignancy and initial findings were correlated with the histopathological outcome...
2016: Clinical Hemorheology and Microcirculation
Deval Parekh, Moumita Sengupta, Mou Das, Uttara Chatterjee
Xanthogranulomatous pyelonephritis is an uncommon inflammatory condition accounting for 1% of chronic pyelonephritis cases. Clinically and radiologically it mimics other renal space occupying lesions. Hence, correct preoperative diagnosis is not possible in all cases and nephrectomy is done in most patients. Renal tubulopapillary adenomas are benign epithelial lesions of kidney found to be associated with papillary renal cell carcinoma, acquired renal cystic disease, long term hemodialysis, arteriosclerotic renal vascular disease, etc...
October 2016: Indian Journal of Pathology & Microbiology
C G Xi, Y Fan, X Y Yang, L B Liu, J H Wang, S Hu, Y Y Li, Q He
OBJECTIVE: To study the clinicopathological features and differential diagnosis of metanephric adenoma (MA). METHODS: The clinicopathological data of 16 cases with MA diagnosed and treated in Peking University First Hospital from 2004 to 2016 were retrospectively analyzed, and the clinical characteristics, pathologic parameters, differential diagnosis, treatment options and prognosis of MA were analyzed with literature review. RESULTS: The patients included 10 females and 6 males...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Ji Yeon Kim
Renal adenomatosis is a rare disease characterized by numerous adenomas in bilateral kidneys. A literature review shows that malignant tumors can arise in this condition. The present case describes an oncocytic papillary renal cell carcinoma (PRCC) arising in renal adenomatosis. A 70-year-old man presented with incidentally identified, multiple right renal masses on computed tomography. Right nephrectomy was performed, and the resected kidney revealed numerous radiologically undetected small nodules additionally...
February 2017: International Journal of Surgical Pathology
X Wang, N Wu, W R Yang, S S Shi, H H Ma, X Wei, X J Zhou, Q Rao
OBJECTIVE: To study the expression of cadherin17(CDH17) in metanephric adenoma (MA), and to explore the value of CDH17 in the diagnosis of metanephric adenoma. METHODS: Immunohistochemical EnVision method was used to detect the expression of CDH17, WT1, CD57, P504S and EMA in 21 cases of MAs, 16 epithelial-predominant Wilms tumors (e-WT), and 20 solid variant of papillary renal cell carcinomas (s-PRCC). The expression of CDH17 was also examined in other common renal epithelial tumors, including 10 cases of clear cell renal cell carcinomas (CCRCC), 10 chromophobe renal cell carcinomas (CHRCC), and 10 oncocytomas...
July 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Elżbieta Andrysiak-Mamos, Ewa Żochowska, Agnieszka Kaźmierczyk-Puchalska, Michał Popow, Dorota Kaczmarska-Turek, Janusz Pachucki, Tomasz Bednarczuk, Anhelli Syrenicz
INTRODUCTION: Hypocalcaemia is a common postoperative complication, both after the resection of parathyroid adenoma associated with primary hyperparathyroidism and after total thyroidectomy due to thyroid cancer or nodular goitre. For a few years, in patients with postoperative hypoparathyroidism and severe hypocalcaemia, who cannot discontinue intravenous calcium preparations even with the use of high vitamin D doses, attempts have been made to add recombinant human parathormone (rhPTH) to the treatment schedule...
2016: Endokrynologia Polska
Hua Fan, Qian-Qian Shao, Han-Zhong Li, Yu Xiao, Yu-Shi Zhang
We describe the clinical presentation, diagnosis, treatment, and follow-up data of a 39-year-old woman with asymptomatic right kidney tumor, which was later histopathologically diagnosed as metanephric adenoma (MA). Macroscopically, the tumor had integrity tegument with homogeneous and gray cutting surface. Microscopically, the tumor cells were formed in adenoid or papillary pattern and contained psammoma bodies, without distinctive atypia. Immunohistochemistry results showed they were negative for creatine kinase 7, epithelial membrane antigen, and renal cell carcinoma, and positive for AE1/AE3, vimentin, and Wilms Tumor 1...
May 2016: Medicine (Baltimore)
Nina Kaerger Billfeldt, Daniel Banyai, Gyula Kovacs
BACKGROUND/AIM: The canonical β-catenin pathway is involved in the development of Wilms' tumor, but its role in adult renal cell tumors (RCT) of embryonal origin is not yet known. MATERIALS AND METHODS: We sequenced the catenin beta 1 (CTNNB1) gene in papillary RCTs, applied the TOPflash/FOPflash reporter plasmid system on cell lines, and examined the β-catenin protein expression by immunohistochemistry. RESULTS: The absence of mutations in CTNNB1 and low TOPflash/FOPflash ratio in tumor cell lines indicated the absence of active Wingless-type MMTV integration site family (WNT) signaling in RCTs...
May 2016: Anticancer Research
Ihab Shafek Atta, Fahd Nasser AlQahtani
We are presenting a case associated with papillary thyroid carcinoma, renal cell carcinoma, invasive mammary carcinoma, chondrosarcoma, benign ganglioneuroma, and numerous colon adenomas. The patient had a family history of colon cancer, kidney and bladder cancers, lung cancer, thyroid cancer, leukemia, and throat and mouth cancers. She was diagnosed with colonic villous adenoma at the age of 41 followed by thyroid, renal, and breast cancers and chondrosarcoma at the ages of 48, 64, 71, and 74, respectively...
2016: Case Reports in Medicine
Holger Moch, Antonio L Cubilla, Peter A Humphrey, Victor E Reuter, Thomas M Ulbright
UNLABELLED: The fourth edition of the World Health Organization (WHO) classification of urogenital tumours (WHO "blue book"), published in 2016, contains significant revisions. These revisions were performed after consideration by a large international group of pathologists with special expertise in this area. A subgroup of these persons met at the WHO Consensus Conference in Zurich, Switzerland, in 2015 to finalize the revisions. This review summarizes the most significant differences between the newly published classification and the prior version for renal, penile, and testicular tumours...
July 2016: European Urology
Tiffany Shao, Peter Yousef, Irina Shipilova, Rola Saleeb, Jason Y Lee, Adriana Krizova
BACKGROUND: Multifocal renal cell carcinoma of different histological subtypes within a single kidney is rare. We report a recently classified clear cell (tubulo) papillary renal cell carcinoma as part of an unusual case of multifocal renal cell carcinoma of discordant histological subtypes. RESULTS: A 57 year-old-man was found to have multiple renal tumors and cysts on imaging and underwent a laparoscopic left radical nephrectomy. Pathological review showed multifocal renal cell carcinoma (clear cell (tubulo) papillary, clear cell and papillary renal cell carcinomas and papillary adenomas)...
March 2016: Pathology, Research and Practice
Kemal Ener, Abdullah Erdem Canda, Serkan Altinova, Ali Fuat Atmaca, Erdal Alkan, Erem Asil, Muhammet Fuat Ozcan, Ziya Akbulut, Mevlana Derya Balbay
The aim of this study was to evaluate outcomes of robotic partial nephrectomy (RAPN) procedures. At two centers, 42 patients underwent RAPN. Radius, Exo/Endophytic, Nearness, Anterior/Posterior, Location (R.E.N.A.L.) nephrometry and PADUA scores of patients were calculated by computed tomography (CT) or magnetic resonance imaging (MRI). Intra- and perioperative (0-30 days) complications were evaluated using modified Clavien classification. A four-arm da Vinci-S robotic surgical system was used and outcomes were evaluated retrospectively...
January 2016: Kaohsiung Journal of Medical Sciences
Maria João Bugalho, Rita Domingues
Multiple endocrine neoplasia type 4 (MEN 4) is a novel form of multiple endocrine neoplasia caused by mutations in the CDKN1B gene. Its clinical presentation includes MEN 1-related tumours such as parathyroid and anterior pituitary tumours in possible association with gonadal, adrenal, renal and thyroid tumours as well as facial angiofibromas, colagenomas and meningiomas. We describe the case of a patient with meningioma, papillary thyroid carcinoma, parathyroid adenoma and, additionally, Hürthle cell adenoma, cholesteatoma and uterine leiomyomas...
January 13, 2016: BMJ Case Reports
Christopher L Welle, Ethany L Cullen, Patrick J Peller, Val J Lowe, Robert C Murphy, Geoffrey B Johnson, Larry A Binkovitz
Choline positron emission tomography (PET)/computed tomography (CT), with both carbon 11 ((11)C) choline and fluorine 18 ((18)F) choline, is an increasingly used tool in the evaluation of patients with biochemically recurrent prostate cancer. It has allowed detection and localization of locally recurrent and metastatic lesions that were difficult or impossible to identify using more conventional modalities. Many of the patients followed for their prostate cancer are elderly and have a higher rate of nonprostate cancer lesions or malignancies...
January 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Aïda Ayadi-Kaddour, Abdelfattah Zeddeni, Emna Braham, Olfa Ismail, Faouzi El Mezni
Tubulopapillary tumors of the kidney represent a particular group of the renal tumors. They cover a continuous spectrum of tumors ranging from the adenoma to the renal cells papillary carcinoma. The histological and immunohistochemical similarities, as well as the high recurrence of the association of these two entities suggest a continuity of the same biological process. Although rare, the association between adenoma and papillary carcinoma remains still subject to controversy and plead in favor of a narrow relation between them...
June 2015: La Tunisie Médicale
Chunge Dong, Youping Yang, Siying Wu, Guorong Chen
Villous adenoma is a rare primary tumor of the urinary system, especially the bladder and kidneys. This study presents two cases of right pelvis villous adenoma, including that of a 61-year-old patient who had experienced hematuria for more than 1 year and was diagnosed with bladder and ureteral stones via B-ultrasound examination, and the other one involving a 65-year-old patient who was hospitalized for 6 days due to a right upper quadrant mass and diagnosed with right renal pelvis stones and hydrops via B-ultrasound examination...
July 2015: Journal of Cancer Research and Therapeutics
Mehmet Bektas, Somashekar G Krishna, William A Ross, Brian Weston, Matthew H Katz, Jason B Fleming, Jeffrey H Lee, Manoop S Bhutani
BACKGROUND AND OBJECTIVES: Extra-pancreatic cysts (EPCs) are incidentally found in patients with pancreatic cystic lesions (PCLs). The aim of this study is to find the prevalence of concurrent EPC in patients with PCLs, investigate associations with neoplastic lesions, and compare the prevalence of EPC to a control population. MATERIALS AND METHODS: A retrospective study of patients who underwent endoscopic ultrasound (EUS) over a 3-year period. The study group consisted of patients with PCLs...
July 2015: Endoscopic Ultrasound
Zhulei Sun, Shihai Kan, Leilei Zhang, Yan Zhang, Hong Jing, Gui Huang, Qichun Yu, Jiang Wu
To assess the clinicopathological, immunohistochemical and molecular features of metanephric adenoma (MA). Clinicopathologic data were obtained for 5 cases of MA with follow-up information. Specimens from these patients were stained by HE and immunohistochemistry for the detection of WT1, vimentin, S-100 protein, CK7, P504s, CD10 and renal cell carcinoma marker (RCC). Fluorescence in situ hybridization (FISH) was performed on 4 tumors. The patients included 1 male and 4 females, aged from 30 to 49 (mean=39) years...
2015: International Journal of Clinical and Experimental Pathology
Stephanie N Kinney, John N Eble, Ondrej Hes, Sean R Williamson, David J Grignon, Mingsheng Wang, Shaobo Zhang, Lee Ann Baldrige, Guido Martignoni, Matteo Brunelli, Lisha Wang, Eva Comperat, Rong Fan, Rodolfo Montironi, Gregory T MacLennan, Liang Cheng
Metanephric adenoma is a benign renal neoplasm that overlaps in morphology with the solid variant of papillary renal cell carcinoma and epithelial-predominant nephroblastoma. To aid in resolving this differential diagnosis, we investigated the utility of immunohistochemical and molecular analyses in distinguishing between these entities; the first study, to our knowledge, to use a combined approach in analyzing all three tumors. We analyzed 37 tumors originally diagnosed as metanephric adenomas (2 of which we reclassified as papillary renal cell carcinomas), 13 solid variant papillary renal cell carcinomas, and 20 epithelial-predominant nephroblastomas using a combination of immunohistochemistry and fluorescence in situ hybridization (FISH) assessing for trisomy of chromosomes 7 and 17 and loss of Y...
September 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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