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Mds and hemolytic anemia

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https://www.readbyqxmd.com/read/27628419/acute-myocardial-infarction-caused-by-thrombotic-microangiopathy-complicated-with-myelodysplastic-syndrome
#1
Tsukasa Oshima, Masayasu Ikutomi, Hiroki Shinohara, Jumpei Ishiwata, Keiko Fukino, Toshihiro Amaki, Fumitaka Nakamura
Thrombotic microangiopathy (TMA) is a rare but lethal multisystem disease characterized by peripheral thrombocytopenia, microangiopathic hemolytic anemia, fever, and various stages of renal and neurological dysfunctions.(1,2)) The causes of TMA are mainly thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome (HUS), and cases of TMA related to myelodysplastic syndrome (MDS) are quite rare. Herein, we report a case of acute myocardial infarction (AMI) caused by TMA which is strongly suspected to have a relationship to MDS, and discuss the treatment of our patient who needed antiplatelet or anticoagulant therapy after AMI, while on the other hand, had pancytopenia and a bleeding event due to MDS...
September 28, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27598686/diagnostic-screening-of-paroxysmal-nocturnal-hemoglobinuria-prospective-multicentric-evaluation-of-the-current-medical-indications
#2
Marta Morado, Alex Freire Sandes, Enrique Colado, Dolores Subirá, Paloma Isusi, María Soledad Noya, María Belén Vidriales, Amparo Sempere, José Ángel Díaz, Alfredo Minguela, Beatriz Álvarez, Cristina Serrano, Teresa Caballero, Mercedes Rey, Ana Pérez Corral, María Cristina Fernández Jiménez, Elena Magro, Angelina Lemes, Celina Benavente, Helena Bañas, Juana Merino, Celine Castejon, Olivier Gutierrez, Pilar Rabasa, Matheus Vescosi Gonçalves, Martin Perez-Andres, Alberto Orfao
BACKGROUND: Although consensus guidelines have been proposed in 2010 for the diagnostic screening of paroxysmal nocturnal hemoglobinuria (PNH) by flow cytometry (FCM), so far no study has investigated the efficiency of such medical indications in multicentric vs. reference laboratory settings. METHODS: Here we evaluate the efficiency of consensus medical indications for PNH testing in 3,938 peripheral blood samples submitted to FCM testing in 24 laboratories in Spain and one reference center in Brazil...
September 6, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27298759/genomic-imbalances-in-peripheral-blood-confirm-the-diagnosis-of-myelodysplastic-syndrome-in-a-patient-presenting-with-non-immune-hemolytic-anemia
#3
Mohammad Faizan Zahid, Nadia Khan, Jianming Pei, Joseph R Testa, Essel Dulaimi
Myelodysplastic syndrome (MDS) is a clonal stem-cell disorder characterized by dyshematopoiesis. We report a patient who presented with cytopenias and microangiopathic hemolytic anemia. Chromosome microarray analysis (CMA), using single nucleotide polymorphism arrays, on peripheral blood revealed genomic imbalances indicative of MDS, which was confirmed by bone marrow examination. This report highlights the importance of suspecting MDS in patients with cytopenias and microangiopathic hemolytic anemia. CMA of peripheral blood may assist in the preliminary diagnosis of MDS, representing a comparatively less invasive diagnostic procedure and may aid bone marrow evaluation when an aspirate sample is insufficient for conventional cytogenetic analysis...
2016: Leukemia Research Reports
https://www.readbyqxmd.com/read/27232106/detection-of-erythroblast-antibodies-in-mitogen-stimulated-bone-marrow-cultures-from-patients-with-myelodysplastic-syndromes
#4
Anna Zaninoni, Francesca G Imperiali, Alessandra Cattaneo, Giulia Soverini, Francesca Binda, Laura Porretti, Agostino Cortelezzi, Wilma Barcellini
BACKGROUND: Low-risk myelodysplastic syndromes (MDS) show several immunologic abnormalities, including increased frequency of autoimmune manifestations and/or overt autoimmune diseases, whose prognostic significance still remains controversial. STUDY DESIGN AND METHODS: We studied the presence of erythroblast antibodies in mitogen-stimulated bone marrow (BM) cultures of 70 patients with early-stage MDS (refractory anemia and refractory anemia with ringed sideroblasts)...
August 2016: Transfusion
https://www.readbyqxmd.com/read/26913410/-significance-of-morphological-examination-cytochemical-staining-combined-with-bone-marrow-biopsy-in-differential-diagnosis-of-myelodysplastic-syndrome-with-low-blasts-and-hemolytic-anemia
#5
Li-Lin Gu, Hui-Yuan Kang, Yu-Ling Pan, Gai-Xia Liu, Su-Jun Ge, Mian-Yang Li, Cheng-Bin Wang
OBJECTIVE: To explore the value of morphological examination, cytochemical staining combined with bone marrow biopsy in the differential diagnosis between myelodysplastic syndrome (MDS) with low blasts and hemolytic anemia (HA). METHODS: The clinical data of 85 cases of myelodysplastic syndrome with low blasts (< 5%) and 61 patients with hemolytic anemia in Chinese PLA's Gerneral hospital from September 2009 to March 2015 were retrospectively analysed. The clinical characteristics, cytogenetic and molecular features, bone marrow cell count and morphology features, cytochemical staining results and bone marrow biopsy features of above-methioned patients were compared...
February 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26708890/-value-of-mcv-rdw-combined-with-reticulocyte-parameters-in-differential-diagnosis-of-anemia-diseases
#6
Li Zhao, Zhi-Gang Mao, Hong Jiang, Li Qin, Chun-Yan Huang, Bin Tan
OBJECTIVE: To evaluate the value of mean corpuscular volume/RBC distribution width (MCV/RDW) combined with reticulocyte parameters in differential diagnosis of aplastic anemia (AA), myelodysplastic syndrome (MDS), megaloblastic anemia (MA) and hemolytic anemia (HA) in order to provide some laboratorial evidence for clinical doctors in first diagnosis of these diseases. METHODS: The data of MCV/RDW and reticulocyte parameters of AA, MDS, MA and HA patients from January 1 of 2011 to August 31 of 2014 were retrospectively collected in West China Hospital of Sichuan University...
December 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26608365/proposal-of-criteria-for-dyserythropoiesis-in-the-diagnosis-of-myelodysplastic-syndromes
#7
Nobutaka Kawai, Akira Matsuda, Itsuro Jinnai, Takaya Ichimura, Hidekazu Kayano, Daisuke Okamura, Maho Ishikawa, Tomoya Maeda, Tomoko Hata, Yasushi Miyazaki, Norio Asou, Masami Bessho, Masao Tomonaga
The percentage manifesting dysplasia in bone marrow needed to qualify as significant is ≥10 % in each lineage. However, detailed analyses of this threshold have not been reported. Here, we analyzed dyserythropoiesis (dysE) in 109 myelodysplastic syndromes (MDS) patients with 21 immune thrombocytopenia (ITP)/12 hemolytic anemia (HA) patients as a control. In present study, mild megaloblastic erythroblasts were specifically named 'red cell with abnormal chromatin clumping (RCACC)'. RCACC ≥10 % in erythroblasts was observed in 29 % of ITP patients and 58 % of HA patients...
February 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/25971272/-cold-autoimmune-hemolytic-anemia-complicated-with-relapsed-myelodysplastic-syndrome-after-allogeneic-hematopoietic-cell-transplantation
#8
Hiroshi Okamura, Takahiko Nakane, Keizo Fujino, Shiro Koh, Takuro Yoshimura, Mitsutaka Nishimoto, Yoshiki Hayashi, Hideo Koh, Yoshitaka Nakao, Hirohisa Nakamae, Masayuki Hino
Myelodysplastic syndrome (MDS) is known to often be complicated by a range of autoimmune diseases. We herein present a case with MDS complicated by cold autoimmune hemolytic anemia (cold AIHA). The patient was a 51-year-old woman. She was diagnosed with MDS (refractory cytopenia with multilineage dysplasia) in May 2009. In January 2010, she underwent unrelated allogeneic bone marrow transplantation but was re-admitted in October 2010 for treatment of relapsed MDS. Despite daily transfusions of red blood cells, her anemia failed to improve...
April 2015: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/25255822/iron-deficiency-anemia-and-anemia-of-chronic-disease-in-geriatric-hospitalized-patients-how-frequent-are-comorbidities-as-an-additional-explanation-for-the-anemia
#9
COMPARATIVE STUDY
Etienne Joosten, Pieter Lioen
AIM: Anemia is an important clinical problem in older patients. The aim of the present study was to investigate whether comorbidities as an additional explanation for the severity of the anemia are frequent, and might help to explain the anemia severity in older patients with iron deficiency anemia (IDA) and the anemia of chronic disease (ACD). METHODS: In the present prospective study, 191 consecutive hospitalized older patients with IDA and the ACD were investigated...
August 2015: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/24756696/concurrent-administration-of-darbepoetin-alfa-cyclosporine-a-and-prednisolone-is-useful-for-t-cell-large-granular-lymphocyte-leukemia-associated-with-myelodysplastic-syndrome-complicated-by-coombs-negative-hemolytic-anemia
#10
LETTER
Tetsumi Yoshida, Keichiro Mihara, Koji Arihiro, Tatsuji Mino, Hideki Asaoku, Tatsuo Ichinohe
No abstract text is available yet for this article.
November 2014: Annals of Hematology
https://www.readbyqxmd.com/read/23801921/physiology-and-pathophysiology-of-eryptosis
#11
Florian Lang, Elisabeth Lang, Michael Föller
Suicidal erythrocyte death (eryptosis) is characterized by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling with phosphatidylserine exposure at the cell surface. Eryptotic cells adhere to the vascular wall and are rapidly cleared from circulating blood. Eryptosis is stimulated by an increase in cytosolic Ca(2)+ activity, ceramide, hyperosmotic shock, oxidative stress, energy depletion, hyperthermia, and a wide variety of xenobiotics and endogenous substances. Inhibitors of eryptosis include erythropoietin and nitric oxide...
October 2012: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/23424599/detection-and-analysis-of-autoantigens-targeted-by-autoantibodies-in-immunorelated-pancytopenia
#12
Hui Liu, Rong Fu, Yihao Wang, Hong Liu, Lijuan Li, Honglei Wang, Jin Chen, Hong Yu, Zonghong Shao
Previously, we described a group of patients with hemocytopenia who did not conform to diagnostic criteria of known hematological and nonhematological diseases. Most patients responded well to adrenocortical hormone and/or high-dose intravenous immunoglobulin treatment, indicating that cytopenia might be mediated by autoantibodies. Autoantibodies were detected on the membrane of various bone marrow (BM) hemopoietic cells by bone marrow mononuclear-cell-Coombs test or flow cytometric analysis. Thus, the hemocytopenia was termed "Immunorelated Pancytopenia" (IRP) to distinguish it from other pancytopenias...
2013: Clinical & Developmental Immunology
https://www.readbyqxmd.com/read/23330877/ectopic-extramedullary-hematopoiesis-evaluation-and-treatment-of-a-rare-and-benign-paraspinal-epidural-tumor
#13
Tobias A Mattei, Michael Higgins, Flynn Joseph, Ehud Mendel
Ectopic extramedullary hematopoiesis (EMH), defined as the formation of blood cells outside the bone marrow, usually occurs in a scenario of chronic anemia when, even after conversion of the bony yellow marrow to red marrow, the body is still unable to meet the demand for red blood cells. Ectopic extramedullary hematopoiesis most commonly occurs in the liver and spleen but may, in fact, occur almost anywhere in the body. Although previous reports have documented EMH presenting as paraspinal masses, such lesions have almost always been associated with a predisposing hematological disorder such as hemolytic anemia, myelofibrosis or myelodysplastic syndromes, thalassemia, polycythemia vera, leukemia, or lymphoma...
March 2013: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/23257446/-comparison-of-bone-marrow-and-blood-cell-morphology-between-refractory-anemia-and-other-anemia-disease
#14
COMPARATIVE STUDY
Hong Cheng, Ming Jiang, Wei DU, Di Zhong, Jian-Ping Hao, Ling Li
This study was purposed to investigate the cell morphological features of bone marrow and peripheral blood in patients with myelodysplastic syndrome, mainly with refractory anemia, and to compare them with other anemia diseases including chronic aplastic anemia, hemolytic anemia and megaloblastic anemia. The bone marrow and peripheral blood were taken from patients for preparing the smears with Wright staining. 500 karyocytes in bone marrow and 100 karyocytes in peripheral blood were detected, and the features of morbid cells of erythrocyte, granulocyte and megakaryocytic series were observed...
December 2012: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/22807898/photosensitivity-and-acute-liver-insufficiency-in-late-onset-erythropoietic-protoporphyria-with-a-chromosome-18q-abnormality
#15
Yuka Oshikawa, Satoshi Fukushima, Taiga Miyake, Takeshi Kawaguchi, Kenta Motomura, Yasuhiro Nakashima, Kenichi Nakamura, Masatoshi Jinnin, Hironobu Ihn
Late-onset erythropoietic protoporphyria (EPP) is rare, and it is usually associated with an acquired somatic mutation of the ferrochelatase gene secondary to hematological malignancy such as myelodysplastic syndrome or myeloproliferative disorder. In 0.5-1% of patients with EPP, deposition of protoporphyrin in the liver leads to progressive liver insufficiency. Herein, we report the case of a 67-year-old female who developed EPP with typical photosensitivity and hemolytic anemia. Six months later, she was admitted with acute liver damage with a rapidly progressing course, and developed liver insufficiency...
May 2012: Case Reports in Dermatology
https://www.readbyqxmd.com/read/22800944/-magnetic-resonance-imaging-and-spectroscopy-of-the-bone-marrow-in-children-with-common-hematological-diseases
#16
Li Xu, Yu Chen, Jia-wei He, Zhi-han Yan, Xin-jian Ye, Guang-hui Bai, Xian Zhang, Zhi-kang Yu
OBJECTIVE: To evaluate the magnetic resonance (MR) imaging and proton magnetic resonance spectroscopy ((1)H-MRS) in the diagnoses of pediatric hematological diseases. METHODS: A total of 35 cases with pediatric hematological diseases were confirmed by bone marrow puncturing. There were acute leukemia (n = 26), aplastic anemia (n = 6), thalassemia (n = 2) and autoimmune hemolytic anemia (n = 1). Thirty age-marched healthy children underwent MR imaging (T(1)WI, T(2)WI, STIR) and (1)H-MRS of lumber spine and ilium...
March 6, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/22629693/-risk-of-development-of-clinical-and-pathogenetic-features-of-anemia-on-the-background-of-basic-therapy-of-inflammatory-bowel-disease
#17
K K Noskova, A A Lishchinskaia, A I Parfenov, O V Kniazev, G G Varvanina, V N Drozdov
Anemia in IBD is the result of a combination of iron deficiency and anemia of chronic disease. Therapy of IBD is relief of inflammation, but the drugs usage may cause the development hemolytic anemia and myelodysplastic syndrome. We studied the effect of basic therapy on the incidence of anemia and assess the impact of modern biological therapies on the main markers of AHZ. A total of 153 patients with ulcerative colitis (UC) and 53 patients with Crohn's disease (CD), which at the time of the study received basic anti-inflammatory therapy for at least 1 year...
2011: Experimental & Clinical Gastroenterology
https://www.readbyqxmd.com/read/22453074/myelodysplasia-followed-by-good-s-syndrome-a-unique-manifestation-associated-with-thymoma
#18
Ling-Ping Chen, Jui-Shan Tsai, Wei-Ming Lai, Ling-Jung Yen, Ming-Sun Yu, Shyh-Jer Lin
Good's syndrome, also known as thymoma with combined immunodeficiency, is rare. The immunodeficiency may precede, arise concurrently with or follow the diagnosis of thymoma. In addition to myasthenia gravis and Good's syndrome, paraneoplastic syndromes associated with thymoma can also be manifested with hematological disorders, such as pure red cell aplasia, aplastic anemia, agranulocytosis, hemolytic anemia, pernicious anemia, and paroxysmal nocturnal hemoglobinuria. Myelodysplastic syndrome is a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more lineages, ineffective hematopoiesis, and potential precursors of acute leukemia...
April 2012: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/22435421/plasma-exchange-and-rituximab-treatment-for-lenalidomide-associated-cold-agglutinin-disease
#19
David L Brauer, Bennett Edelman, Aaron P Rapoport, John R Hess, Görgün Akpek
BACKGROUND: Lenalidomide is an amino-substituted analog of thalidomide with potent immunomodulatory properties. The drug has been widely used for treatment of multiple myeloma and myelodysplastic syndrome (MDS) associated with 5q-abnormality. The most common side effects are cytopenias, infections, and deep venous thrombosis. CASE STUDY: We report a clinical observation of severe autoimmune hemolytic anemia (AIHA) due to cold agglutinin disease (CAD) that developed 11 days after initiation of lenalidomide treatment in a patient with MDS who relapsed after allogeneic bone marrow transplantation...
November 2012: Transfusion
https://www.readbyqxmd.com/read/22280850/-evans-syndrome-be-careful-of-over-diagnosis
#20
H Eddou, C Helissey, J Konopacki, B Souleau, T de Revel, J V Malfuson
INTRODUCTION: Evans syndrome (ES) is characterized by the coexistence of an autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP). Despite being frequently evocated in the simultaneous presence of anemia and thrombocytopenia, this rare disease only accounts for 0.8 to 3.7% of patients with ITP or AIHA. CASE REPORTS: We report three suspected cases of ES, diagnosed in the presence of thrombocytopenia and hemolytic anemia association, with a positive direct Coombs test in two patients...
March 2012: La Revue de Médecine Interne
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