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Epithelioid osteosarcoma

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https://www.readbyqxmd.com/read/27683125/reduced-argininosuccinate-synthetase-expression-in-refractory-sarcomas-impacts-on-therapeutic-potential-and-drug-resistance
#1
Youngji Kim, Eisuke Kobayashi, Daisuke Kubota, Yoshiyuki Suehara, Kenta Mukaihara, Keisuke Akaike, Ayumu Ito, Kazuo Kaneko, Hirokazu Chuman, Akira Kawai, Shigehisa Kitano
BACKGROUND: Treating drug-resistant sarcomas remains a major challenge. The present study aimed to identify a novel therapy for drug-resistant sarcomas based on metabolic errors involving argininosuccinate synthetase1 (ASS1). RESULTS: ASS1 expression was reduced in Dox-resistant sarcoma cells. Immunohistochemistry and real-time PCR showed an inverse correlation between ASS1 and P-gp expressions. The inhibition of cellular proliferation with G1-arrest was shown to lead to autophagy with arginine deprivation...
September 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27660729/biphasic-malignant-pleural-mesothelioma-masquerading-as-a-primary-skeletal-tumor
#2
James Benjamin Gleason, Basheer Tashtoush, Maria Julia Diacovo
Biphasic malignant pleural mesothelioma is a rare malignant tumor, usually presenting as a pleural-based mass in a patient with history of chronic asbestos exposure. We herein report a case of a 41-year-old man who presented with chest pain and had a chest computed tomography (CT) scan suggestive of a primary skeletal tumor originating from the ribs (chondrosarcoma or osteosarcoma), with no history of asbestos exposure. CT-guided core needle biopsies were diagnosed as malignant sarcomatoid mesothelioma. Surgical resection and chest wall reconstruction were performed, confirming the diagnosis and revealing a secondary histologic component (epithelioid), supporting the diagnosis of biphasic malignant mesothelioma...
2016: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/27601840/epithelioid-osteoblastoma-of-maxilla-a-rare-and-aggressive-variant-of-a-benign-neoplasm-at-an-uncommon-site
#3
Vandana Rana, Vivek Saxena, Kavita Sahai, Giriraj Singh
Osteoblastoma (OB) is an uncommon benign bone-forming tumor accounting for <1% of all bone neoplasms. Unlike conventional OB, its small subset variant "Epithelioid osteoblastoma (EO)" is characterized by its propensity for local invasion and recurrent behavior. This rare variant of an uncommon tumor when occurs in an atypical site can lead to diagnostic problems more so due to ambiguous clinico-radiologic presentation. This was what faced in the present case of 18-year-old female with a swelling in upper jaw...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27561385/giant-cell-rich-osteosarcoma-of-the-parotid-gland-an-exceptionally-rare-entity-at-an-unusual-site
#4
Eric C Huang, Varand Ghazikhanian, Xiaohua Qian
Giant cell-rich osteosarcoma is a rare histologic variant of conventional osteosarcoma that affects mainly the extremities. Extraskeletal giant cell-rich osteosarcoma is therefore exceedingly rare. Here, we report the first case of this uncommon tumor involving the parotid gland in a 62-year-old male who presented with initial right jaw swelling. Radiologic work-up revealed a 6.2 cm mass involving the right parotid gland. Fine-needle aspiration cytology showed numerous multinucleated giant cells in a background of dyshesive epithelioid cells and rare clusters of spindle stromal cells, suspicious for malignancy...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27442626/primary-epithelioid-sarcoma-of-the-zygomatic-bone
#5
Henry Tran, Nick Shillingford, Stefanie Thomas, Jeffrey Hammoudeh, Shengmei Zhou
Primary epithelioid sarcoma of bone is extremely rare with only two reported cases in the English literature. A previously healthy 18-year-old male presented with a six-month history of right facial numbness and tingling and right eye diplopia. CT scan revealed an ill-defined mass with dense osseous matrix centered in the right zygomatic bone. An outside biopsy was read as osteosarcoma. The resection specimen revealed large epithelioid and spindle cells embedded in a prominent hyalinized matrix with focal metaplastic bone formation...
July 21, 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/26879443/-rosette-forming-epithelioid-osteosarcoma-in-childhood-report-of-a-case
#6
Ming Han, Shoujing Yang
No abstract text is available yet for this article.
February 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/26625859/invasive-pleural-malignant-mesothelioma-with-rib-destruction-and-concurrent-osteosarcoma-in-a-dog
#7
Morena Di Tommaso, Francesca Rocconi, Giuseppe Marruchella, Anna Rita D'Angelo, Stefano Masci, Domenico Santori, Carla Civitella, Alessia Luciani, Andrea Boari
A 7-year-old Dachshund was clinically examined because of a 10-day history of lameness in the left hind limb. On the basis of radiological and cytological findings, an osteosarcoma of the left acetabular region was suspected. The dog underwent a hemipelvectomy and osteosarcoma was diagnosed by subsequent histopathological examination. An immovable subcutaneous mass was noted on the left chest wall during the physical examination and non-septic neutrophilic inflammation was diagnosed by cytology. Forty days later, the dog showed signs of respiratory distress with an in-diameter increase of the subcutaneous mass up to 4 cm...
2015: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/26507845/epithelioid-multinodular-osteoblastoma-of-the-mandible-a-case-report-and-review-of-literature
#8
Shruti Kashikar, Michael Steinle, Renee Reich, Paul Freedman
Epithelioid multinodular osteoblastoma is a rare variant of osteoblastoma characterized by numerous nodules of epithelioid osteoblasts surrounding bony trabeculae, as well as clusters of epithelioid osteoblasts without osteoid formation. It commonly occurs in the gnathic bones of the face and spine, and has a male predominance. To date, only 26 cases of epithelioid multinodular osteoblastoma have been reported and described in detail in the literature. Lucas et al. (Hum Pathol 25:117-134, 1994) described 43 cases of a variant of osteoblastoma that he termed epithelioid multifocal osteoblastoma...
June 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/26209924/sclerosing-epithelioid-fibrosarcoma-of-the-thigh-report-of-two-cases-with-synchronous-bone-metastases
#9
A Righi, M Gambarotti, M Manfrini, S Benini, G Gamberi, S Cocchi, R Casadei, P Picci, D Vanel, A P Dei Tos
We report two cases of sclerosing epithelioid fibrosarcoma occurring in the deep soft tissue of the thigh, confirmed by molecular analysis and associated with bone metastases in the lumbar vertebrae and the iliac wing at the time of diagnosis. Synchronous bone metastases of sclerosing epithelioid fibrosarcoma are extremely difficult to diagnose because clinical and radiological features are not specific. In addition, the range of differential diagnoses is very wide, including metastatic carcinoma and osteosarcoma...
September 2015: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/26134029/l-type-amino-acid-transporter-1-and-cd98-expression-in-bone-and-soft-tissue-tumors
#10
Hiromi Koshi, Takaaki Sano, Tadashi Handa, Takashi Yanagawa, Kenichi Saitou, Shushi Nagamori, Yoshikatsu Kanai, Kenji Takagishi, Tetsunari Oyama
L-type amino acid transporter-1 (LAT1) is expressed in many cancers. We examined LAT1 and CD98 expression immunohistochemically in surgically resected specimens of various bone and soft tissue tumors. Out of 226 cases, 79 (35%) were LAT1(+) and 95 (42%) were CD98(+) . In bone tumors, LAT1 was highly expressed in osteoblastoma (89%), chondrosarcoma (50%), and osteosarcoma (60%); in soft tissue tumors, LAT1 was highly expressed in rhabdomyosarcoma (80%), synovial sarcoma (63%), Ewing's sarcoma (60%), epithelioid sarcoma (100%) and angiosarcoma (100%)...
September 2015: Pathology International
https://www.readbyqxmd.com/read/26113662/epithelioid-osteosarcoma-of-the-maxilla-a-case-report-and-review-of-the-literature
#11
REVIEW
Dalal ALQahtani, Manal AlSheddi, Ra'ed Al-Sadhan
Epithelioid osteosarcoma is an uncommon variant; only 4 cases have been reported in the jaw area, 2 of which were in the maxilla. A 22-year-old woman, in the eighth month of pregnancy, presented to the oral surgery clinic with a mass in the right maxilla that had rapidly expanded over the past 3 months. Computed tomography scans showed an ill-defined sclerotic destructive lesion that formed bone matrix in its soft tissue extension. Microscopic examination of the lesion revealed malignant epithelioid cells with osteoid deposits...
September 2015: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25770040/diversity-of-histologic-patterns-and-expression-of-cytoskeletal-proteins-in-canine-skeletal-osteosarcoma
#12
E Nagamine, K Hirayama, K Matsuda, M Okamoto, T Ohmachi, T Kadosawa, H Taniyama
Osteosarcoma (OS), the most common bone tumor, includes OS of the head (OSH) and appendicular OS (OSA). In dogs, it is classified into 6 histologic subtypes: osteoblastic, chondroblastic, fibroblastic, telangiectatic, giant cell, and poorly differentiated. This study investigated the significance of the histologic classification relevant to clinical outcome and the histologic and immunohistochemical relationships between pleomorphism and expression of cytoskeletal proteins in 60 cases each of OSH and OSA. Most neoplasms exhibited histologic diversity, and 64% of OS contained multiple subtypes...
September 2015: Veterinary Pathology
https://www.readbyqxmd.com/read/25683346/anaplastic-lymphoma-kinase-protein-expression-genetic-abnormalities-and-phosphorylation-in-soft-tissue-tumors-phosphorylation-is-associated-with-recurrent-metastasis
#13
Yukinao Ishibashi, Hiroaki Miyoshi, Koji Hiraoka, Fumiko Arakawa, Toshiaki Haraguchi, Shinji Nakashima, Toshihiro Hashiguchi, Takanori Shoda, Tetsuya Hamada, Takahiro Okawa, Fujio Higuchi, Naoto Shiba, Kensei Nagata, Koichi Ohshima
Gene and protein abnormalities of anaplastic lymphoma kinase (ALK) play an important role in the pathogenesis of various cancers and serve as important therapeutic targets. We investigated ALK protein expression, phosphorylation, and genetic aberrations using fluorescence in situ hybridization (FISH) in 81 soft tissue tumor samples: inflammatory myofibroblastic tumor, n=1; alveolar soft part sarcoma, n=2; leiomyosarcoma, n=10; well-differentiated liposarcoma, n=7; pleomorphic liposarcoma, n=2; extraskeletal osteosarcoma, n=1; epithelioid sarcoma, n=1; synovial sarcoma, n=4; malignant peripheral nerve sheath tumor, n=4; undifferentiated pleomorphic sarcoma, n=19; rhabdomyosarcoma, n=6; myxofibrosarcoma, n=8; myxoid liposarcoma, n=11; fibrosarcoma, n=4; and desmoid-type fibromatosis, n=1...
April 2015: Oncology Reports
https://www.readbyqxmd.com/read/25393249/intimal-sarcomas-of-the-aorta-and-iliofemoral-arteries-a-clinicopathological-study-of-26-cases
#14
Paul Staats, Fabio Tavora, Allen P Burke
Aortic sarcomas are predominantly endoluminal tumours that are believed derived from the intima. Because of their rarity, relatively little is known about their pathological features. We report a series of 26 aortic and iliofemoral tumours with histopathological and clinical data.Of the 26 cases, there were 16 men (63.6 ± 13 years) and 10 women (58.6 ± 18 years). Tumours occurred in the abdominal aorta (13), descending thoracic aorta (8), iliac or femoral arteries (4) and ascending aorta (1). Presenting tumour manifestations included claudication or peripheral vascular disease (6), pain (5), pulsatile aneurysm (2) abdominal aortic aneurysm (AAA; 2), occluded graft (2), renal artery stenosis (1), pain from bone metastasis (1), aortic rupture (1), fever (1), weight loss (1), vasculitis (1) impotence (1), incidental finding (1) and bowel ischaemia (1)...
December 2014: Pathology
https://www.readbyqxmd.com/read/25244180/epiphyseal-osteosarcoma-revisited-four-illustrative-cases-with-unusual-histopathology-and-literature-review
#15
Louis Tsun Cheung Chow, Simon Kwok Chuen Wong
Osteosarcomas arising in the epiphysis are extremely rare and easily missed in the diagnostic consideration of epiphyseal tumors. It is the purpose of this study to delineate the clinical pathological characteristics of 'epiphyseal osteosarcoma' under the definition of 'a solitary long bone osteosarcoma radiographically considered an epiphyseal tumor for which the main radiologic differential diagnosis would encompass giant cell tumor, chondroblastoma and clear cell chondrosarcoma'. Four such cases with unusual histopathology were retrieved among 110 cases of osteosarcoma...
January 2015: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/25137500/epithelioid-osteosarcoma-of-the-scapula
#16
G W Herget, C Otto, P Kurz, M Uhl, C-P Adler, N P Südkamp, O Hauschild
Epithelioid and epithelial neoplasms of bone are rare. They include different epithelioid variants of vascular lesions, osteoblastoma, chondroblastoma and most importantly metastatic carcinoma. Up to now, only few cases of epithelioid osteosarcoma were described. In this case the authors report a 53-year-old patient presented with a medical history of chronic shoulder pain for 3 years. Magnetic resonance imaging (MRI and computed tomography (CT) showed a destructive, partially calcified osseous lesion of the scapula with expansion into the surrounding soft tissue, suggestive of a primary bone tumor...
2014: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/24921641/primary-sclerosing-epithelioid-fibrosarcoma-of-bone-analysis-of-a-series
#17
John B Wojcik, Andrew M Bellizzi, Paola Dal Cin, Miriam A Bredella, Christopher D M Fletcher, Francis J Hornicek, Vikram Deshpande, Jason L Hornick, G Petur Nielsen
Sclerosing epithelioid fibrosarcoma (SEF) is a rare, aggressive malignant neoplasm characterized by small nests and linear arrays of epithelioid cells embedded in a dense collagenous matrix. Very few primary SEFs of bone have been reported. Recognition is critical, as the dense extracellular collagenous matrix can be interpreted as osteoid, leading to misdiagnosis as-osteosarcoma. MUC4 and SATB2 are 2 recently characterized immunohistochemical markers for SEF and osteosarcoma, respectively. In reports to date, osteosarcomas are positive for SATB2 and negative for MUC4, whereas soft tissue SEFs have shown the opposite immunohistochemical profile (SATB2-/MUC4+)...
November 2014: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/24710732/sclerosing-rhabdomyosarcoma-presentation-of-a-rare-sarcoma-mimicking-myoepithelial-carcinoma-of-the-parotid-gland-and-review-of-the-literature
#18
REVIEW
Blake M Warner, Christopher C Griffith, William D Taylor, Raja R Seethala
Sclerosing rhabdomyosarcoma (SRMS), a recently characterized variant of rhabdomyosarcoma, can pose a significant diagnostic challenge given its rarity and its histological similarity to other malignancies. SRMS is characterized by dense hyalinized or sclerosing collagenous matrix and a pseudovascular pattern of growth. SRMS shares histologic similarities with several mesenchymal tumors including: leiomyosarcoma, osteosarcoma, chondrosarcoma, angiosarcoma, and sclerosing epithelioid fibrosarcoma. We herein report a case of SRMS mimicking a myoepithelial carcinoma of the parotid gland...
March 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/24239184/outcomes-after-limb-sparing-resection-in-primary-malignant-pelvic-tumors
#19
A Puri, M Pruthi, A Gulia
AIM: To evaluate morbidity, oncologic results and functional outcome in patients with malignant tumors of pelvis treated with limb sparing resection. METHODS: Between March 2002 and November 2010, 106 cases of non metastatic malignant pelvic tumors were treated with limb sparing resections of pelvis. Diagnosis included chondrosarcoma (65), Ewing's sarcoma (25), osteogenic sarcoma (10), synovial sarcoma (3) and malignant fibrous histiocytoma, high grade sarcoma, epitheloid hemangiothelioma (1 each)...
January 2014: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/24137403/primary-osteosarcoma-of-the-breast-with-abundant-chondroid-matrix-and-fibroblasts-has-a-good-prognosis-a-case-report-and-review-of-the-literature
#20
Jingjie Zhao, Xuedong Zhang, Jianwei Liu, Jianhua Li
The present study describes the case of a 77-year-old female with a recently self-detected, painless, 7-cm lump in the left breast, without evidence of metastasis clinically, who underwent mastectomy with dissection of the axillary lymph nodes. The tumor did not invade the chest wall and skin. The tumor was comprised of abundant chondroid matrix and fibrous tissue, with focal osteoid matrix, and was classified as a chondroblastic/fibroblastic variant. The tumor had a reverse zonal pattern. The tumor cells in the central portion were mainly spindle-like and sparse with minimal cytological atypia, while the remaining tumor cells in the periphery were mainly epithelioid, atypical and dense...
September 2013: Oncology Letters
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