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https://www.readbyqxmd.com/read/29667344/concise-review-aggressive-colorectal-cancer-role-of-epithelial-cell-adhesion-molecule-in-cancer-stem-cells-and-epithelial-to-mesenchymal-transition
#1
REVIEW
Maximilian Boesch, Gilbert Spizzo, Andreas Seeber
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In spite of various attempts to ameliorate outcome by escalating treatment, significant improvement is lacking particularly in the adjuvant setting. It has been proposed that cancer stem cells (CSCs) and the epithelial-to-mesenchymal transition (EMT) are at least partially responsible for therapy resistance in CRC. The epithelial cell adhesion molecule (EpCAM) was one of the first CSC antigens to be described. Furthermore, an EpCAM-specific antibody (edrecolomab) has the merit of having launched the era of monoclonal antibody treatment in oncology in the 1990s...
April 17, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29666139/last-year-of-life-study-cologne-lyol-c-protocol-for-a-cross-sectional-mixed-methods-study-to-examine-care-trajectories-and-transitions-in-the-last-year-of-life-until-death
#2
Julia Strupp, Gloria Hanke, Nicolas Schippel, Holger Pfaff, Ute Karbach, Christian Rietz, Raymond Voltz
INTRODUCTION: The last year of life constitutes a particularly vulnerable phase for patients, involving nearly all health and social care structures. Yet, little scientific evidence is available that provides insight into the trajectories including the number and types of care setting transitions, transitions into palliative care and the dying phase. Only few studies have focused on difficulties associated with having to move between health and social care settings in the last year of life, although patients face a significant risk of adverse events...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665695/women-in-rural-family-medicine-a-qualitative-exploration-of-practice-attributes-that-promote-physician-satisfaction
#3
Carol Hustedde, Heather Paladine, Andrea Wendling, Rupa Prasad, Orlando Sola, Sarah Bjorkman, Julie Phillips
INTRODUCTION: The USA needs more rural physicians. Although women represent half of all US trained medical students, the rural physician workforce has remained predominantly male. Insight is needed into what makes rural practice attractive for women and which practice characteristics allow women physicians to practice successfully in rural areas. This study's purpose was to examine aspects of the practice environment that impact women physicians' professional satisfaction and commitment to rural medicine...
April 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29662720/role-of-active-versus-passive-complementary-and-integrative-health-approaches-in-pain-management
#4
David Cosio, Erica Lin
Background: A general conclusion about the treatment of chronic, noncancer pain is that the results from traditional, passive modalities are disheartening. Perhaps this may be due to the propensity of patients to seek out passive versus active treatments. In pain management, active treatments should be the primary focus, with passive interventions as an adjunct. Objective: The current study tested the hypotheses that Veterans would report a greater significant increase in active versus transitional and active versus passive complementary and integrative health (CIH) utilization after completing a formal pain education program...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29662530/are-we-ready-for-routine-precision-medicine-highlights-from-the-milan-summit-on-precision-medicine-milan-italy-8-9-february-2018
#5
Luca Mazzarella
On 8 and 9 February 2018, the IFOM-IEO campus in Milan hosted the Milan summit on Precision Medicine, which gathered clinical and translational research experts from academia, industry and regulatory bodies to discuss the state of the art of precision medicine in Europe. The meeting was pervaded by a generalised feeling of excitement for a field that is perceived to be technologically mature for the transition into clinical routine but still hampered by numerous obstacles of a methodological, ethical, regulatory and possibly cultural nature...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662302/hot-water-extract-of-the-branches-of-hovenia-dulcis-thunb-rhamnaceae-ameliorates-low-fiber-diet-induced-constipation-in-rats
#6
Chul-Yung Choi, Seung-Sik Cho, In-Soo Yoon
Hovenia dulcis Thunb. (Rhamnaceae), also known as oriental raisin tree, is used in traditional herbal medicine. Its extracts have been reported to show various pharmacological effects such as hepatoprotection, antitumor, antiatopic dermatitis, antilipid peroxidation, anti-steatotic, anti-inflammatory, and antiallergic activities. However, there have been no reports on the effect of H. dulcis extracts in relieving constipation so far. The aim of this study was to investigate the effects of a hot-water extract of the branches of H...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29661107/implementation-of-health-information-exchange-at-the-pima-county-adult-detention-complex-lessons-learned
#7
Alyssa Hinchman, Sara Hodges, James Backus, Terri Warholak
Successful transition of patients between health care entities is difficult. Historically, the process of transitioning individuals through the corrections system with regard to health care was made even more challenging by the limitation of paper records. Recently, the advent of electronic medical records has improved health care nationwide. The use of health information exchange (HIE) systems in areas such as emergency medicine has also impacted patient outcomes. To date, this technology has not been used in the corrections system...
April 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29660841/design-of-trifluoroalkenyliodonium-salts-for-hypervalency-aided-alkenylation-cyclization-strategy-metal-free-construction-of-aziridine-ring
#8
Zoltán Novák, Ádám Mészáros, Anna Székely, András Stirling
Synthesis of fluorinated compounds and their use as pharmaceutical ingredients or synthetic building blocks are in the focus of chemical and medicinal research. However, the efficient synthesis of trifluoromethylated nitrogen heterocycles sometimes are challenging. Herein, we disclose a simple aziridination process which relies on the use of amines and novel alkenyl synthon for the access of trifluoromethylated strained heterocycle. With the utilization of a newly designed, bench stable but highly reactive hypervalent alkenyl iodonium species, the three membered heterocyclic ring can be constructed from simple amines without structural limitation with high efficiency under mild conditions in the absence of transition metal catalysts...
April 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29659694/nutritional-genomics-and-direct-to-consumer-genetic-testing-an-overview
#9
Marta Guasch-Ferré, Hassan S Dashti, Jordi Merino
The increasing prevalence in polygenic diseases, such as obesity, cardiovascular disease, and type 2 diabetes, observed over the past few decades is more likely linked to a rapid transition in lifestyle rather than to changes in the sequence of the nuclear genome. In the new era of precision medicine, nutritional genomics holds the promise to be translated into tailored nutritional strategies to prevent and manage polygenic diseases more effectively. Nutritional genomics aims to prevent, treat, and manage polygenic diseases through targeted therapies formulated from individuals' genetic makeup and dietary intake...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29656941/submucosal-gland-myoepithelial-cells-are-reserve-stem-cells-that-can-regenerate-mouse-tracheal-epithelium
#10
Thomas J Lynch, Preston J Anderson, Pavana G Rotti, Scott R Tyler, Adrianne K Crooke, Soon H Choi, Daniel T Montoro, Carolyn L Silverman, Weam Shahin, Rui Zhao, Chandler W Jensen-Cody, Andrea Adamcakova-Dodd, T Idil Apak Evans, Weiliang Xie, Yulong Zhang, Hongmei Mou, B Paul Herring, Peter S Thorne, Jayaraj Rajagopal, Charles Yeaman, Kalpaj R Parekh, John F Engelhardt
The mouse trachea is thought to contain two distinct stem cell compartments that contribute to airway repair-basal cells in the surface airway epithelium (SAE) and an unknown submucosal gland (SMG) cell type. Whether a lineage relationship exists between these two stem cell compartments remains unclear. Using lineage tracing of glandular myoepithelial cells (MECs), we demonstrate that MECs can give rise to seven cell types of the SAE and SMGs following severe airway injury. MECs progressively adopted a basal cell phenotype on the SAE and established lasting progenitors capable of further regeneration following reinjury...
April 6, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29650743/improving-transition-to-adulthood-for-adolescents-with-intellectual-and-developmental-disabilities-proactive-developmental-and-systems-perspective
#11
REVIEW
Shara Ally, Kerry Boyd, Dara Abells, Khush Amaria, Yani Hamdani, Alvin Loh, Ullanda Niel, Samantha Sacks, Sarah Shea, William F Sullivan, Brian Hennen
OBJECTIVE: To demonstrate how family physicians can contribute to a piece of the journey of improving quality-of-life outcomes for people with intellectual and developmental disabilities (IDD) when they undergo the transition from adolescence to adulthood. SOURCES OF INFORMATION: The "Primary care of adults with intellectual and developmental disabilities. 2018 Canadian consensus guidelines" literature review and interdisciplinary input. MAIN MESSAGE: Family physicians should be proactive in anticipating and supporting the transition of people with IDD from adolescence to adulthood...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29643075/widespread-changes-in-transcriptome-profile-of-human-mesenchymal-stem-cells-induced-by-two-dimensional-nanosilicates
#12
James K Carrow, Lauren M Cross, Robert W Reese, Manish K Jaiswal, Carl A Gregory, Roland Kaunas, Irtisha Singh, Akhilesh K Gaharwar
Two-dimensional nanomaterials, an ultrathin class of materials such as graphene, nanoclays, transition metal dichalcogenides (TMDs), and transition metal oxides (TMOs), have emerged as a new generation of materials due to their unique properties relative to macroscale counterparts. However, little is known about the transcriptome dynamics following exposure to these nanomaterials. Here, we investigate the interactions of 2D nanosilicates, a layered clay, with human mesenchymal stem cells (hMSCs) at the whole-transcriptome level by high-throughput sequencing (RNA-seq)...
April 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29627824/protective-effect-of-znt7-on-high-glucose-induced-epithelial-to-mesenchymal-transition-in-renal-tubular-epithelial-cells
#13
Xiuli Zhang, Xu Lian, Dan Liang, Lianzhi Zhang, Shengquan Liu, Lina Yang, Zhi-Hong Chi, Harvest F Gu
BACKGROUND/AIMS: Evidence from our and other groups has demonstrated that zinc transporter 7 in SLC30 family (ZnT7) inhibited epithelial-to-mesenchymal transition (EMT) and apoptosis in rat peritoneal mesothelial cells (RPMCs) under high glucose (HG) concentration. In the present study, we investigated the effect of ZnT7 on EMT of renal tubular epithelial cells (RTECs) in an in vitro model of diabetic nephropathy (DN). METHODS: A dual-fluorescent staining protocol was used for detection of ZnT7 in a normal rat kidney tubular epithelial cell line (NRK-52E cells)...
March 29, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29623191/art-in-science-competition-invites-artworks-to-the-annual-exhibition-on-ismb-2018-in-chicago
#14
EDITORIAL
Lonnie Welch, Bruno Gaeta, Diane E Kovats, Milana Frenkel Morgenstern
The International Society of Computational Biology and Bioinformatics (ISCB) brings together scientists from a wide range of disciplines, including biology, medicine, computer science, mathematics and statistics. Practitioners in these fields are constantly dealing with information in visual form: from microscope images and photographs of gels to scatter plots, network graphs and phylogenetic trees, structural formulae and protein models to flow diagrams, visual aids for problem-solving are omnipresent. The ISCB Art in Science Competition 2017 at the ISCB/ECCB 2017 conference in Prague offered a way to show the beauty of science in art form...
2018: F1000Research
https://www.readbyqxmd.com/read/29623157/collaborative-comanagement-between-neurohospitalists-and-internal-medicine-hospitalists-decreases-provider-costs-and-enhances-satisfaction-with-neurology-care-at-an-academic-medical-center
#15
James G Greene
Background and Purpose: The majority of academic medical centers are moving to a neurohospitalist model of care for hospital neurology coverage. Potential benefits over a more traditional academic model of patient care include greater expertise in acute neurologic disease, increased efficiency, and improved availability to patients, providers, and learners. Despite these perceived advantages, switching to a neurohospitalist model can come at substantial financial cost, so finding ways to maximize the positive impact of a limited number of neurohospitalists is very important to the future health of academic neurology departments...
April 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29622030/mapping-human-pluripotent-stem-cell-differentiation-pathways-using-high-throughput-single-cell-rna-sequencing
#16
Xiaoping Han, Haide Chen, Daosheng Huang, Huidong Chen, Lijiang Fei, Chen Cheng, He Huang, Guo-Cheng Yuan, Guoji Guo
BACKGROUND: Human pluripotent stem cells (hPSCs) provide powerful models for studying cellular differentiations and unlimited sources of cells for regenerative medicine. However, a comprehensive single-cell level differentiation roadmap for hPSCs has not been achieved. RESULTS: We use high throughput single-cell RNA-sequencing (scRNA-seq), based on optimized microfluidic circuits, to profile early differentiation lineages in the human embryoid body system. We present a cellular-state landscape for hPSC early differentiation that covers multiple cellular lineages, including neural, muscle, endothelial, stromal, liver, and epithelial cells...
April 5, 2018: Genome Biology
https://www.readbyqxmd.com/read/29621360/the-combination-of-cassia-obtusifolia-l-and-foeniculum-vulgare-m-exhibits-a-laxative-effect-on-loperamide-induced-constipation-of-rats
#17
Seung Hee Jang, Dong Kwon Yang
Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life. Cassia obtusifolia L. (CO) and Foeniculum vulgare M. (FV) are commonly used as medicinal foods in many countries. We aimed to examine the laxative effect and their underlying mechanism of CO and FV mixture on loperamide (lop)-induced constipated rats. To determine the laxative effects of these compounds, Sprague-Dawley rats were divided into six groups: the control, lop-induced constipated (2mg/kg), and three doses (100, 300, and 500mg/kg) of CO and FV mixture-, and Bisacodyl (bis, 3...
2018: PloS One
https://www.readbyqxmd.com/read/29619837/creating-and-evaluating-an-opportunity-for-medication-reconciliation-in-the-adult-population-of-south-africa-to-improve-patient-care
#18
Pranusha Naicker, Natalie Schellack, Brian Godman, Elmien Bronkhorst
BACKGROUND AND AIMS: Adverse drug events (ADEs) are a major cause of morbidity and mortality, with more than 50% of ADEs being preventable. Adverse Drug Reactions (ADRs) are typically the result of an incomplete medication history, prescribing or dispensing error, as well as over- or under-use of prescribed pharmacotherapy. Medication reconciliation is the process of creating the most accurate list of medications a patient is taking and subsequently comparing the list against the different transitions of care...
April 5, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29619590/a-novel-high-resolution-method-for-the-respiration-rate-and-breathing-waveforms-remote-monitoring
#19
Boris G Vainer
A search for robust noninvasive methods permitting to discern the respiration subtle peculiarities in mammals is a topical issue. A novel approach called "sorption-enhanced infrared thermography" (SEIRT), helping to solve this problem, is described. Its benefits spring from the integration of the infrared thermography (IRT) and chemical physics (phase transition heat release/absorption) within a single method. The SEIRT opportunities were verified in the investigation of 42 humans, 49 rats and 4 minipigs whose breathing waveforms were revealed to the last detail...
April 4, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29619243/two-dimensional-material-based-bionano-platforms-to-control-mesenchymal-stem-cell-differentiation
#20
REVIEW
Ee-Seul Kang, Da-Seul Kim, Intan Rosalina Suhito, Wanhee Lee, Inbeom Song, Tae-Hyung Kim
Background: In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repair damaged parts of organs and tissues, the use of stem cells still entails several limitations, such as low differentiation efficiency and difficulties in guiding differentiation. To address these limitations, nanotechnology approaches have been recently implemented in stem cell research...
2018: Biomaterials Research
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