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https://www.readbyqxmd.com/read/28323628/effects-of-bach-flower-remedies-on-menopausal-symptoms-and-sleep-pattern-a-case-report
#1
Marcele Siegler, Cristina Frange, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Context • During the postmenopausal stage, women go through many remarkable changes, including physical, emotional, and hormonal. They also experience some unwanted effects, such as vasomotor symptoms, anxiety, and insomnia. The use of Bach flower remedies has been described as a supporting therapy for those symptoms. Objectives • The investigation aimed to evaluate the effects of the supplement on sleep pattern (ie, sleep perception and objective sleep) and on menopausal symptoms. Design • The research team created a case report...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28318863/it-is-a-brave-new-world-alternative-payment-models-and-value-creation-in-total-joint-arthroplasty-creating-value-for-tjr-quality-and-cost-effectiveness-programs
#2
Kevin K Chen, Jonathan H Harty, Joseph A Bosco
BACKGROUND: The increasing cost of our country's healthcare is not sustainable. To address this crisis, the federal government is transiting healthcare reimbursement from the traditional volume-based system to a value-based system. As such, increasing healthcare value has become an essential point of discussion for all healthcare stakeholders. METHODS: The purpose of this study is to discuss the importance of healthcare value as a means to achieve this goal of value-based medicine and 3 methods to create value in total joint arthroplasty...
February 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28317677/trends-in-cataract-surgery-training-curricula
#3
Mona Lotfipour, Ramunas Rolius, Erik B Lehman, Seth M Pantanelli, Ingrid U Scott
PURPOSE: To evaluate trends in cataract surgery training curricula and factors affecting timing of resident participation as a primary surgeon. SETTING: Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA. DESIGN: Cross-sectional study of anonymous survey results. METHODS: A description of the study and link to an online survey was e-mailed to program directors of each ophthalmology residency training program accredited by the Accreditation Council for Graduate Medical Education (ACGME)...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28306185/-i-have-nine-specialists-they-need-to-swap-notes-australian-patients-perspectives-of-medication-related-problems-following-discharge-from-hospital
#4
Daniela Eassey, Andrew J McLachlan, Jo-Anne Brien, Ines Krass, Lorraine Smith
BACKGROUND: Research has shown that patients are most susceptible to medication-related problems (MRPs) when transitioning from hospital to home. Currently, the literature in this area focuses on interventions, which are mainly orientated around the perspective of the health-care professional and do not take into account patient perspectives and experiences. OBJECTIVE: To capture the experiences and perceptions of Australian patients regarding MRPs following discharge from hospital...
March 17, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28303693/the-opinions-of-radiographers-nuclear-medicine-technologists-and-radiation-therapists-regarding-technology-in-health-care-a-qualitative-study
#5
Sil Aarts, Forra Cornelis, Yke Zevenboom, Patrick Brokken, Nicole van de Griend, Miriam Spoorenberg, Wendy Ten Bokum, Eveline Wouters
INTRODUCTION: New technology is continuously introduced in health care. The aim of this study was (1) to collect the opinions and experiences of radiographers, nuclear medicine technologists and radiation therapists regarding the technology they use in their profession and (2) to acquire their views regarding the role of technology in their future practice. METHODS: Participants were recruited from five departments in five hospitals in The Netherlands. All radiographers, nuclear medicine therapists and radiation therapists who were working in these departments were invited to participate (n = 252)...
March 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28299801/bi-allelic-alterations-in-dna-repair-genes-underpin-homologous-recombination-dna-repair-defects-in-breast-cancer
#6
Robert W Mutter, Nadeem Riaz, Charlotte K Y Ng, Rob Delsite, Salvatore Piscuoglio, Marcia Edelweiss, Luciano G Martelotto, Rita A Sakr, Tari A King, Dilip D Giri, Maria Drobnjak, Edi Brogi, Ranjit Bindra, Giana Bernheim, Raymond S Lim, Pedro Blecua, Alexis Desrichard, Dan Higginson, Russell Towers, Ruomu Jiang, William Lee, Britta Weigelt, Jorge S Reis-Filho, Simon N Powell
Homologous recombination (HR) DNA repair deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence suggests that sporadic breast cancers, lacking germline BRCA1/BRCA2 mutations, may also be HRD. We developed a functional ex vivo RAD51-based test to identify HRD primary breast cancers. An integrated approach examining methylation, gene expression and whole-exome sequencing was employed to ascertain the etiology of HRD. Functional HRD breast cancers displayed genomic features of lack of competent HR, including large-scale state transitions and specific mutational signatures...
March 15, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28299341/hepatic-cholesterol-25-hydroxylase-overexpression-improves-systemic-insulin-sensitivity-in-mice
#7
Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner
Obesity is a major risk factor for several diseases including diabetes, heart disease, and some forms of cancer and due to its rapidly increasing prevalence it has become one of the biggest problems medicine is facing today. All the more surprising, a substantial percentage of obese patients are metabolically healthy when classified based on insulin resistance and systemic inflammation. Oxysterols are naturally occurring molecules that play important role in various metabolic and inflammatory processes and their levels are elevated in patients suffering from obesity and diabetes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28299321/jianpi-jiedu-recipe-inhibits-epithelial-to-mesenchymal-transition-in-colorectal-cancer-through-tgf-%C3%AE-smad-mediated-snail-e-cadherin-expression
#8
Xuan Liu, Qing Ji, Wanli Deng, Ni Chai, Yuanyuan Feng, Lihong Zhou, Hua Sui, Chunpu Li, Xiaoting Sun, Qi Li
JPJD was an ideal alternative traditional Chinese medicine compound in the prevention and treatment of CRC, but its underlying mechanisms has not been fully elucidated. In this study, we demonstrated in vitro that TGF-β-induced EMT promoted the invasion and metastasis of CRC cells, reduced the expression of E-cadherin, and elevated the expression of Vimentin. However, JPJD could inhibit the invasive and migratory ability of TGF-β-stimulated CRC cells in a concentration-dependent manner through increasing the expression of E-cadherin and repressing the expression of Vimentin, as well as the inhibition of TGF-β/Smad signaling pathway...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28297600/a-high-throughput-survey-of-ordering-configurations-in-mxene-alloys-across-compositions-and-temperatures
#9
Teck Leong Tan, Hong Mei Jin, Michael Brian Sullivan, Babak Anasori, Yury Gogotsi
2D transition metal carbides and nitrides known as MXenes are gaining increasing attention. About 20 of them have been synthesized (more predicted) and their applications in fields ranging from energy storage and electromagnetic shielding to medicine are being explored. To facilitate the search for new double-transition-metal MXenes, we explore the structure-stability relationship for 8 MXene alloy systems, namely, (V1-xMox)3C2, (Nb1-xMox)3C2, (Ta1-xMox)3C2, (Ti1-xMox)3C2, (Ti1-xNbx)3C2, (Ti1-xTax)3C2, (Ti1-xVx)3C2 and (Nb1-xVx)3C2,¬ with 0 ≤ x ≤ 1, using high-throughput computations...
March 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28297566/instructive-role-of-the-microenvironment-in-preventing-renal-fibrosis
#10
Kei Matsumoto, Sandhya Xavier, Jun Chen, Yujiro Kida, Mark Lipphardt, Reina Ikeda, Annie Gevertz, Mario Caviris, Antonis K Hatzopoulos, Ivo Kalajzic, James Dutton, Brian B Ratliff, Hong Zhao, Zbygniew Darzynkiewicz, Stefan Rose-John, Michael S Goligorsky
Accumulation of myofibroblasts is a hallmark of renal fibrosis. A significant proportion of myofibroblasts has been reported to originate via endothelial-mesenchymal transition. We initially hypothesized that exposing myofibroblasts to the extract of endothelial progenitor cells (EPCs) could reverse this transition. Indeed, in vitro treatment of transforming growth factor-β1 (TGF-β1)-activated fibroblasts with EPC extract prevented expression of α-smooth muscle actin (α-SMA); however, it did not enhance expression of endothelial markers...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28293673/monitoring-and-analysis-of-the-change-process-in-curriculum-mapping-compared-to-the-national-competency-based-learning-objective-catalogue-for-undergraduate-medical-education-nklm-at-four-medical-faculties-part-ii-key-factors-for-motivating-the-faculty-during
#11
Maria Lammerding-Koeppel, Marianne Giesler, Maryna Gornostayeva, Elisabeth Narciss, Annette Wosnik, Stephan Zipfel, Jan Griewatz, Olaf Fritze
Objective: After adoption of the National Competency-based Learning Objectives Catalogue in Medicine [Nationaler Kompetenzbasierter Lernzielkatalog Medizin, NKLM], the German medical faculties are asked to test the learning obejctives recorded in it and evaluate them critically. The faculties require curricular transparency for competence-oriented transition of present curricula, which is best achieved by systematic curriculum mapping in comparison to the NKLM. Based on this inventory, curricula can be further developed target-oriented...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28291556/teaching-communication-skills-to-radiology-residents
#12
Jason N Itri, Sammy Yacob, Ayman Mithqal
The transition of health care in the United States from volume to value requires a systems-based approach aligning clinical services across the continuum of care. The ability to communicate effectively and resolve conflict is a critical skill within the systems-based model. Recognizing the essential role of communication in medicine, the Accreditation Council of Graduate Medical Education has designated interpersonal and communication skills a core competency for all residents regardless of specialty. Yet, communication skills are often developed through on-the-job training or not at all...
January 17, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28289384/theabrownin-inhibits-cell-cycle-progression-and-tumor-growth-of-lung-carcinoma-through-c-myc-related-mechanism
#13
Li Zhou, Feifei Wu, Wangdong Jin, Bo Yan, Xin Chen, Yingfei He, Weiji Yang, Wenlin Du, Qiang Zhang, Yonghua Guo, Qiang Yuan, Xiaoqiao Dong, Wenhua Yu, Jin Zhang, Luwei Xiao, Peijian Tong, Letian Shan, Thomas Efferth
Green tea, the fresh leaves of Camellia sinensis, is not only a health-promoting beverage but also a traditional Chinese medicine used for prevention or treatment of cancer, such as lung cancer. Theabrownin (TB) is the main fraction responsible for the medicinal effects of green tea, but whether it possesses anti-cancer effect is unknown yet. This study aimed to determine the in vitro and in vivo anti-lung cancer effect of TB and explore the underlying molecular mechanism, by using A549 cell line and Lewis lung carcinoma-bearing mice...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28286260/mir-181d-malt1-regulatory-axis-attenuates-mesenchymal-phenotype-through-nf-%C3%AE%C2%BAb-pathways-in-glioblastoma
#14
Fan Yang, Xing Liu, Yanwei Liu, Yuqing Liu, Chuanbao Zhang, Zheng Wang, Tao Jiang, Yongzhi Wang
The mesenchymal (MES) subtype of glioblastoma (GBM) indicated a more malignant phenotype and worse prognosis compared with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided an approach for clinical intervention. However, few miRNAs have been identified to participate in the shift between subtypes. Here, we utilized transcriptomic data and experimental evidences to prove that miR-181d was a novel regulator of NFκB signalling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES genes...
March 9, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28282995/understanding-copd-overlap-syndromes
#15
Tuang Yeow Poh, Micheál Mac Aogáin, Adrian Kwok Wai Chan, Anthony Chau Ang Yii, Valerie Fei Lee Yong, Pei Yee Tiew, Mariko Siyue Koh, Sanjay Haresh Chotirmall
Chronic obstructive pulmonary disease accounts for a large burden of lung disease. It can 'overlap' with other respiratory diseases including bronchiectasis, fibrosis and obstructive sleep apnea (OSA). While COPD alone confers morbidity and mortality, common features with contrasting clinical outcomes can occur in COPD 'overlap syndromes'. Areas Covered: Given the large degree of heterogeneity in COPD, individual variation to treatment is adopted based on its observed phenotype, which in turn overlaps with features of other respiratory disease states such as asthma...
March 10, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28279921/computational-smart-polymer-design-based-on-elastin-protein-mutability
#16
Anna Tarakanova, Wenwen Huang, Anthony S Weiss, David L Kaplan, Markus J Buehler
Soluble elastin-like peptides (ELPs) can be engineered into a range of physical forms, from hydrogels and scaffolds to fibers and artificial tissues, finding numerous applications in medicine and engineering as "smart polymers". Elastin-like peptides are attractive candidates as a platform for novel biomaterial design because they exhibit a highly tunable response spectrum, with reversible phase transition capabilities. Here, we report the design of the first virtual library of elastin-like protein models using methods for enhanced sampling to study the effect of peptide chemistry, chain length, and salt concentration on the structural transitions of ELPs, exposing associated molecular mechanisms...
January 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/28279652/the-transition-to-the-committee-on-tactical-combat-casualty-care
#17
REVIEW
Stephen D Giebner
The original Tactical Combat Casualty Care (TCCC) guidelines were published in a special supplement to Military Medicine in 1996 as the terminal deliverable of a 2-year development project funded by the United States Special Operations Command (USSOCOM). Two years later, the USSOCOM Biomedical Initiatives Steering Committee (BISC) promulgated its Task Statement 5-98, in which it called for the formation of a panel of subject matter experts to update the TCCC guidelines. This article discusses the formation of the Committee on Tactical Combat Casualty Care (CoTCCC) and the changes to the original guidelines that constituted the first update...
March 6, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28279543/emergency-department-holding-orders
#18
Stephen J Traub, M'Hamed Temkit, Soroush Saghafian
BACKGROUND: Holding orders help transition admitted emergency department (ED) patients to hospital beds. OBJECTIVE: To describe the effect of ED holding orders. METHODS: We conducted a single-site retrospective study of ward admissions from the ED to the hospital internal medicine (HIM) service over 2 years. Patients were classified based on whether the ED did (group 1) or did not (group 2) write holding orders; group 1 was subdivided into patients sent to the floor with only ED holding orders (group 1A) vs...
March 6, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28277005/development-of-a-rapid-in-vitro-tissue-deadhesion-system-using-the-thermoresponsive-sol-gel-transition-of-hydroxybutyl-chitosan
#19
Asuka Kato, Kai Kan, Hiroharu Ajiro, Mitsuru Akashi
In regenerative medicine, it has become increasingly important to collect cultured tissues using non-invasive methods. Enzymatic deadhesion is normally used to collect cells, but this method cannot be used when trying to collect whole tissues in order to avoid damaging cell-cell interactions. In order to resolve this issue, a thermoresponsive culture dish with poly(N-isopropyl acrylamide) (PNIPAAm) has been employed. This system can change its hydrophobicity depending on temperature. Thus, tissues can attach above 37 °C and be detached below 20 °C...
February 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28277003/on-off-affinity-binding-modulation-on-thermoresponsive-polymer-grafted-surfaces-for-capture-and-release-of-proteins-and-cells
#20
Jun Kobayashi, Masayuki Yamato, Teruo Okano
This review describes new types of thermoresponsive surfaces modified with biologically active ligands to thermally modulate on-off affinity binding between ligands and receptors. To achieve the thermal regulation of affinity binding, molecules of thermoresponsive polymer poly(N-isopropylacrylamide) (PIPAAm) are typically used to tune the degree of steric hindrance in response to temperature. The coil-to-globule transition of surface-grafted PIPAAm chains induces dynamic changes in the degree of steric hindrance in the vicinity of the immobilized ligand, resulting in the thermoresponsive modulation of on-off affinity interactions with receptors, and the subsequent on-off switching of the capture and release of proteins and cells on the surface...
February 22, 2017: Journal of Biomaterials Science. Polymer Edition
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