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https://www.readbyqxmd.com/read/29446868/the-amyloid-polymorphism-in-the-protein-folding-and-aggregation-energy-landscape
#1
Raffaele Mezzenga, Jozef Adamcik
Protein folding (and misfolding) is of paramount importance to an extraordinary vast class of fields, spanning from biochemistry to biology, medicine, biophysics and statistical thermodynamics. The folding process involves a large number of steps and conformations in which the folding protein samples different thermodynamic states characterized by local minima and activation energies in between. The kinetically trapped on- or off-pathway intermediates identifying the relative minima are metastable folding intermediates towards the lowest absolute energy minima, which have been postulated to be the natively folded state for the regime in which the intramolecular interactions dominate, and the amyloid status for the regime where intermolecular interactions rule...
February 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29444759/current-management-of-pelvic-organ-prolapse-in-aging-women
#2
Andrea Giannini, Eleonora Russo, Antonio Cano, Peter Chedraui, Dimitrios G Goulis, Irene Lambrinoudaki, Patrice Lopes, Gita Mishra, Alfred Mueck, Margaret Rees, Levent M Senturk, John C Stevenson, Petra Stute, Pauliina Tuomikoski, Tommaso Simoncini
Management of pelvic organ prolapse (POP) is a common and challenging task. Nowadays older women are more active than they were in the past, and the development of POP disrupts quality of life and impairs social and personal activities. The menopausal transition is a time of vulnerability, during which many women start experiencing symptoms and signs of POP. The role of hormonal changes or of hormonal therapies in influencing the development or progression of POP has been explored extensively. The management of POP requires considerable clinical skills...
February 6, 2018: Maturitas
https://www.readbyqxmd.com/read/29435856/modern-theories-of-pelvic-floor-support-a-topical-review-of-modern-studies-on-structural-and-functional-pelvic-floor-support-from-medical-imaging-computational-modeling-and-electromyographic-perspectives
#3
REVIEW
Yun Peng, Brandi D Miller, Timothy B Boone, Yingchun Zhang
PURPOSE OF REVIEW: Weakened pelvic floor support is believed to be the main cause of various pelvic floor disorders. Modern theories of pelvic floor support stress on the structural and functional integrity of multiple structures and their interplay to maintain normal pelvic floor functions. Connective tissues provide passive pelvic floor support while pelvic floor muscles provide active support through voluntary contraction. Advanced modern medical technologies allow us to comprehensively and thoroughly evaluate the interaction of supporting structures and assess both active and passive support functions...
February 12, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29432396/gathering-tips-from-carers-to-support-people-with-dementia-an-adaptation-of-the-top-5-program-for-community-use
#4
Kerrie Westaway, Oliver Frank, Russell Shute, Anna Moffat, Vanessa LeBlanc, Debra Rowett, Natalie Blacker, Elizabeth Roughead
AIM: Behavioral and psychological symptoms of dementia are often managed inappropriately with antipsychotic medicines. The TOP 5 program, which involves recording up to five relevant and meaningful tips that assist in personalizing care for the person with dementia, has been tested in the hospital setting and transitions of care in Australia, and has been found to be useful. Our study aimed to adapt the TOP 5 program as a strategy to support people with dementia in a primary care setting and to test the acceptability of our adapted TOP 5 program materials...
February 9, 2018: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/29427880/selective-and-rapid-determination-of-tadalafil-and-finasteride-using-solid-phase-extraction-by-high-performance-liquid-chromatography-and-tandem-mass-spectrometry
#5
Nagaraju Pappula, Balaji Kodali, Peda Varma Datla
Highly selective and fast liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for simultaneous determination of tadalafil (TDL) and finasteride (FNS) in human plasma. The method was successfully applied for analysis of TDL and FNS samples in clinical study. The method was validated as per USFDA (United States Food and Drug Administration), EMA (European Medicines Agency), and ANVISA (Agência Nacional de Vigilância Sanitária-Brazil) bio analytical method validation guidelines...
February 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29427590/antioxidant-potentials-of-nanoceria-synthesized-by-solution-plasma-process-and-its-biocompatibility-study
#6
MubarakAli Davoodbasha, Bo-Ram Park, Won-Jong Rhee, Sang-Yul Lee, Jung-Wan Kim
Nanoceria were synthesized by discharging plasma at 800 V with a frequency of 30 kHz for 0-25min using a pulsed unipolar power supply into solutions containing Ce(NO3)2 (1 and 2 mM). UV-Vis spectroscopy showed a characteristic absorbance maxima at 304-320 nm for the nanoceria with increase in the intensity of the peaks as the concentration of Ce(NO3)2 increased. The peaks exhibited transition to red shift due to nanoceria formation. HRTEM showed spherical shaped nanoparticles with average size of 7...
February 7, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29425244/initiation-extension-and-termination-of-rna-synthesis-by-a-paramyxovirus-polymerase
#7
Paul C Jordan, Cheng Liu, Pauline Raynaud, Michael K Lo, Christina F Spiropoulou, Julian A Symons, Leo Beigelman, Jerome Deval
Paramyxoviruses represent a family of RNA viruses causing significant human diseases. These include measles virus, the most infectious virus ever reported, in addition to parainfluenza virus, and other emerging viruses. Paramyxoviruses likely share common replication machinery but their mechanisms of RNA biosynthesis activities and details of their complex polymerase structures are unknown. Mechanistic and functional details of a paramyxovirus polymerase would have sweeping implications for understanding RNA virus replication and for the development of new antiviral medicines...
February 9, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29417295/the-effect-of-a-medication-reconciliation-program-in-two-intensive-care-units-in-the-netherlands-a-prospective-intervention-study-with-a-before-and-after-design
#8
Liesbeth B E Bosma, Nicole G M Hunfeld, Rogier A M Quax, Edmé Meuwese, Piet H G J Melief, Jasper van Bommel, SiokSwan Tan, Maaike J van Kranenburg, Patricia M L A van den Bemt
BACKGROUND: Medication errors occur frequently in the intensive care unit (ICU) and during care transitions. Chronic medication is often temporarily stopped at the ICU. Unfortunately, when the patient improves, the restart of this medication is easily forgotten. Moreover, temporal ICU medication is often unintentionally continued after ICU discharge. Medication reconciliation could be useful to prevent such errors. Therefore, the aim of this study was to determine the effect of medication reconciliation at the ICU...
February 7, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29416995/prevalence-of-risk-factors-of-noncommunicable-diseases-in-a-rural-population-of-district-gautam-budh-nagar-uttar-pradesh-using-the-world-health-organization-steps-approach
#9
Shalini Srivastav, Harsh Mahajan, Sonia Goel, Sidhyartha Mukherjee
Context: Globally, it is estimated that by 2020, noncommunicable diseases (NCDs) will account for 73% of deaths and 60% of disease burden. India is in the midst of an epidemiological transition leading to increasing the prevalence of NCDs. Targeting the risk factors for NCDs is recognized as an essential preventive strategy. Aims: The rationale of this study was to decipher the baseline data on the prevalence of NCD risk factors among the rural population. Settings and Design: A community-based cross-sectional study was conducted among 207 adults in the rural catchment area of the Department of Community Medicine...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29413524/mu-opioid-pharmacology-40-years-to-the-promised-land
#10
Gavril W Pasternak
Opioids continue to play a major role in medicine, but not without problems. Side effects limit their utility medically, while the potential of addiction has had a major societal impact. Pharmacologists have been trying to develop opioids lacking side effects since the first derivative, heroin, was synthesized in the 1870s. The identification of opioid receptors about 40 years ago opened up new insights into our understanding of opioid action, fueled by the molecular biology revolution of the 1980s and 1990s...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29406182/guidelines-for-the-management-of-tracheal-intubation-in-critically-ill-adults
#11
A Higgs, B A McGrath, C Goddard, J Rangasami, G Suntharalingam, R Gale, T M Cook
These guidelines describe a comprehensive strategy to optimize oxygenation, airway management, and tracheal intubation in critically ill patients, in all hospital locations. They are a direct response to the 4 th National Audit Project of the Royal College of Anaesthetists and Difficult Airway Society, which highlighted deficient management of these extremely vulnerable patients leading to major complications and avoidable deaths. They are founded on robust evidence where available, supplemented by expert consensus opinion where it is not...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29398641/diagnosis-and-management-of-duchenne-muscular-dystrophy-part-3-primary-care-emergency-management-psychosocial-care-and-transitions-of-care-across-the-lifespan
#12
REVIEW
David J Birnkrant, Katharine Bushby, Carla M Bann, Susan D Apkon, Angela Blackwell, Mary K Colvin, Linda Cripe, Adrienne R Herron, Annie Kennedy, Kathi Kinnett, James Naprawa, Garey Noritz, James Poysky, Natalie Street, Christina J Trout, David R Weber, Leanne M Ward
Improvements in the function, quality of life, and longevity of patients with Duchenne muscular dystrophy (DMD) have been achieved through a multidisciplinary approach to management across a range of health-care specialties. In part 3 of this update of the DMD care considerations, we focus on primary care, emergency management, psychosocial care, and transitions of care across the lifespan. Many primary care and emergency medicine clinicians are inexperienced at managing the complications of DMD. We provide a guide to the acute and chronic medical conditions that these first-line providers are likely to encounter...
February 1, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29397121/management-of-perceived-devastating-brain-injury-after-hospital-admission-a-consensus-statement-from-stakeholder-professional-organizations
#13
D Harvey, J Butler, J Groves, A Manara, D Menon, E Thomas, M Wilson
Patients with severe grades of life-threatening brain injury are commonly characterized as having devastating brain injury (DBI), which we have defined as: 'any neurological condition that is assessed at the time of hospital admission as an immediate threat to life or incompatible with good functional recovery AND where early limitation or withdrawal of therapy is being considered'. The outcome in patients with DBI is often death or severe disability, and as a consequence rapid withdrawal of life sustaining therapies is commonly contemplated or undertaken...
January 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29395804/peptide-chemistry-toolbox-transforming-natural-peptides-into-peptide-therapeutics
#14
Miloš Erak, Kathrin Bellmann-Sickert, Sylvia Els-Heindl, Annette G Beck-Sickinger
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became an emerging market in pharmaceutical industry. The need for synthetic strategies in order to improve peptidic properties, such as longer half-life, higher bioavailability, increased potency and efficiency is accordingly rising. In this mini-review, we present a toolbox of modifications in peptide chemistry for overcoming the main drawbacks during the transition from natural peptides to peptide therapeutics...
January 29, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29394529/regulation-of-tgf-%C3%AE-smad-mediated-epithelial-mesenchymal-transition-by-celastrol-provides-protection-against-bleomycin-induced-pulmonary-fibrosis
#15
Thomas Divya, Bakthavatchalam Velavan, Ganapasam Sudhandiran
The respiratory disease pulmonary fibrosis (PF), which is characterized by scar formation throughout the lung, imposes a serious health burden. No effective drug without side effects has been proven to prevent this fatal lung disease. In this context, the present study was undertaken to elucidate the protective effect of celastrol, a quinine methide pentacyclic triterpenoid from a Chinese medicinal plant 'thunder God vine' against bleomycin (BLM)-induced PF. We also attempted to study how the cytokine transforming growth factor-β (TGF-β) stimulates fibrosis through the induction of epithelial-mesenchymal transition (EMT) and the role of celastrol in regulating EMT...
February 2, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29385577/interprofessional-case-conference-impact-on-learner-outcomes
#16
Jeffrey Sordahl, India C King, Kyle Davis, Rick Tivis, Scott C Smith, Amber Fisher, Janet Willis, Timothy Gordon, William G Weppner
Transition to interprofessional team-based care is a quickly progressing healthcare model and requires changes in medical training approaches. The Department of Veteran Affairs (VA) has taken a lead role in creating such training experiences, one of which is the establishment of multiple Centers of Excellence in Primary Care Education (CoEPCE). These sites are tasked with developing teaching innovations to better facilitate interprofessional team-based care. The patient-aligned care team interprofessional care update (PACT-ICU) is an interprofessional workplace learning activity with the goals of simultaneously addressing educational and patient care needs...
January 27, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29384444/predictors-of-readiness-for-mobility-transition-in-older-drivers
#17
Deepika Kandasamy, Annie C Harmon, Thomas M Meuser, David B Carr, Marian E Betz
OBJECTIVES: To examine attitudinal readiness for mobility transition (e.g., driving retirement) in a healthy older driver sample. METHODS: 301 older (≥65 years) adults who were not cognitively impaired and were currently driving, recruited from three internal medicine clinics, completed the short-form Assessment of Readiness for Mobility Transition, a previously-validated tool. Total scores were compared by demographic and other participant characteristics. RESULTS: Median age was 72 (range: 65-93)...
January 31, 2018: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/29383741/chart%C3%A2-stalking-list-making-and-physicians-efforts-to-track-patients-outcomes-after-transitioning-responsibility
#18
Judith L Bowen, Bridget C O'Brien, Jonathan S Ilgen, David M Irby, Olle Ten Cate
CONTEXT: Transitions of patient care responsibility occur frequently between physicians. Resultant discontinuities make it difficult for physicians to observe clinical outcomes. Little is known about what physicians do to overcome the practical challenges to learning these discontinuities create. This study explored physicians' activities in practice as they sought follow-up information about patients. METHODS: Using a constructivist grounded theory approach, semi-structured interviews with 18 internal medicine hospitalist and resident physicians at a single tertiary care academic medical center explored participants' strategies when deliberately conducting follow-up after they transitioned responsibility for patients to other physicians...
January 30, 2018: Medical Education
https://www.readbyqxmd.com/read/29378822/whole-genome-sequence-accuracy-is-improved-by-replication-in-a-population-of-mutagenized-sorghum
#19
Charles Addo-Quaye, Mitch Tuinstra, Nicola Carraro, Clifford Weil, Brian P Dilkes
The accurate detection of induced mutations is critical for both forward and reverse genetics studies. Experimental chemical mutagenesis induces relatively few single base changes per individual. In a complex eukaryotic genome, false positive detection of mutations can occur at or above this mutagenesis rate. We demonstrate here, using a population of ethyl methanesulfonate (EMS) treated Sorghum bicolor BTx623 individuals, that using replication to detect false positive induced variants in next-generation sequencing data permits higher throughput variant detection with greater accuracy...
January 29, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29369424/non-contrast-enhanced-4d-intracranial-mr-angiography-based-on-pseudo-continuous-arterial-spin-labeling-with-the-keyhole-and-view-sharing-technique
#20
Makoto Obara, Osamu Togao, Gabriele M Beck, Shuhei Shibukawa, Tomoyuki Okuaki, Masami Yoneyama, Masanobu Nakamura, Hiroshi Honda, Marc Van Cauteren
PURPOSE: 4D dynamic MR angiography (4D-MRA) using pseudo-continuous arterial spin labeling (pCASL), combined with Keyhole and View-sharing (4D-PACK) for scan acceleration, is introduced. Its validity for arterial inflow dynamics visualization was investigated through comparison with 4D-pCASL and contrast inherent inflow enhanced multiphase angiography (CINEMA). METHODS: Six healthy volunteers were included in the study. The arterial transit time (ATT) in 4D-PACK was measured at multiple regions in middle cerebral artery (MCA), and Pearson's correlation coefficient with ATT in 4D-pCASL was calculated...
January 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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