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https://www.readbyqxmd.com/read/29242368/lessons-from-ckd-related-genetic-association-studies-moving-forward
#1
Sophie Limou, Nicolas Vince, Afshin Parsa
Over the past decade, genetic association studies have uncovered numerous determinants of kidney function in the general, diabetic, hypertensive, CKD, ESRD, and GN-based study populations (e.g., IgA nephropathy, membranous nephropathy, FSGS). These studies have led to numerous novel and unanticipated findings, which are helping improve our understanding of factors and pathways affecting both normal and pathologic kidney function. In this review, we report on major discoveries and advances resulting from this rapidly progressing research domain...
December 14, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29237195/-interdisciplinary-inpatient-treatment-for-adolescents-and-young-adults-16%C3%A2-%C3%A2-25-years-with-mental-illness-in-adolescent-psychiatry
#2
Anne Karow, Michael Lipp, Eva Schweigert, Mary Sengutta, Gaby Wiltfang, Linus Wittmann, Martin Lambert, Carola Bindt, Jürgen Gallinat, Michael Schulte-Markwort
Objective The investigation of clinical characteristics of patients in adolescence psychiatry relevant for transition medicine. Methodology Sociodemographic and clinical data (SCID I/II, SIPS/SOPS, SPI-A, GAF, CGI) were consecutively taken from the interdisciplinary inpatient treatment centre for adolescents and young adults with mental disorders (N = 229, aged 16 - 25). Results Average age was 19 years (38 % male, 23 % migration background). A high proportion of early mental illnesses and comorbidities (66 %), psychosis risk syndromes (20 %) and suicidality (54 %), treatment discontinuation (33 %) with daily-life, social and family stress factors (52 % positive family history, 34 % trauma) were observed and a persistently high level of support and treatment was needed despite a significant clinical improvement (p < 0...
December 13, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29231473/-clinical-observation-of-slow-transit-constipation-treated-with-acupuncture-and-modified-weitong-xiaopi-formula
#3
Bo Wang, Yanping Chen, Suning Chen
OBJECTIVE: To compare the difference in the clinical therapeutic effects on slow transit constipation (STC) among the combined therapy of acupuncture and herbal medicine, simple use of herbal medicine and simple use of western medication. METHODS: Ninety patients of STC were randomized into three groups, 30 cases in each one. In the combined therapy group, acupuncture was used in combination with the modified weitong xiaopi formula. In the Chinese herbal medicine group, the modified weitong xiaopi formula was adopted...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231178/internal-structure-and-swelling-behaviour-of-i-in-silico-i-microgel-particles
#4
Lorenzo Rovigatti, Nicoletta Gnan, Emanuela Zaccarelli
Microgels are soft colloids that, in virtue of their polymeric nature, can react to external stimuli such as temperature or pH by changing their size. The resulting swelling/deswelling transition can be exploited in fundamental research as well as for many diverse practical applications, ranging from art restoration to medicine. Such an extraordinary versatility stems from the complex internal structure of the individual microgels, each of which is a crosslinked polymer network. Here we employ a recently-introduced computational method to generate realistic microgel configurations and look at their structural properties, both in real and Fourier space, for several temperatures across the volume phase transition as a function of the crosslinker concentration and of the confining radius employed during the ``in-silico'' synthesis...
December 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29230392/non-invasive-monitoring-of-cardiac-output-in-critical-care-medicine
#5
REVIEW
Lee S Nguyen, Pierre Squara
Critically ill patients require close hemodynamic monitoring to titrate treatment on a regular basis. It allows administering fluid with parsimony and adjusting inotropes and vasoactive drugs when necessary. Although invasive monitoring is considered as the reference method, non-invasive monitoring presents the obvious advantage of being associated with fewer complications, at the expanse of accuracy, precision, and step-response change. A great many methods and devices are now used over the world, and this article focuses on several of them, providing with a brief review of related underlying physical principles and validation articles analysis...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29228876/crossing-professional-cultures-a-qualitative-study-of-nurses-working-in-a-medical-school
#6
Eileen McKinlay, Peter Gallagher, Bernadette Jones, Lindsay Macdonald, Christine Barthow
BACKGROUND: Leaving the nursing workforce is often seen as a loss to the profession. However some nurses maintain a current nursing registration and work outside their disciplinary field within university schools of medicine. Little is known about the nature of their work and why they choose to work in this setting. AIM: To explore and describe the experiences of nurses who work in a medical school. DESIGN: Qualitative descriptive informed by autoethnography...
December 11, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/29226232/connecting-undergraduate-and-postgraduate-medical-education-through-an-elective-epa-based-transitional-year-in-acute-care-an-early-project-report
#7
Gersten Jonker, Reinier G Hoff, Stefan Max, Cor J Kalkman, Olle Ten Cate
Objective: A well-designed final year may ease the transition from medical school to postgraduate training, if it has enough depth to enable the acquisition of early specialty expertise, while keeping enough breadth to support the graduation as all-round physician. Aim of this article is to describe the design of a multidisciplinary dedicated transitional year (DTY) around the theme of recognition and initial treatment of vitally threatened patients. Methods: Undergraduate and postgraduate training directors from the departments of Anaesthesiology, Cardiology, Emergency Medicine, Intensive Care Medicine and Respiratory Medicine at UMC Utrecht and partnering hospitals have collaboratively developed and implemented a curriculum for a final year focusing on three entrustable professional activities (EPAs) in the domain of acute care...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/29224269/-surgical-treatment-and-early-mid-follow-up-results-of-complete-atrioventricular-septal
#8
H J Cui, J Zhuang, J M Chen, J Z Cen, G Xu, S S Wen
Objective: To discuss the surgical treatment and early-mid follow-up results of complete atrioventricular septal defect (CAVSD). Methods: The clinic data of 235 cases of CAVSD underwent surgical treatment at Department of Cardiac Surgery, Guangdong General Hospital from June 2009 to June 2016 was analyzed retrospectively (104 male and 131 female patients). The patients were aged 18 days to 58 years (mid age 8.9 months) at surgery, and 2 cases of newborns (0.9%), 24 cases of 1 to 3 months (10.2%), 56 cases of 4 to 6 months (23...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29222032/assessment-of-the-laxative-activity-of-an-ethanolic-extract-of-bambusa-arundinacea-retz-willd-shoot
#9
S M Neamul Kabir Zihad, Sanjib Saha, Md Sifujjaman Rony, Hasna Banu, Shaikh J Uddin, Jamil A Shilpi, I Darren Grice
ETHNOBOTANICAL RELEVANCE: Bambusa arundinacea (Retz.) Willd., commonly known as Kanta Bans, plays an important ethnobotanical role, especially in Asia. In traditional medicine it has reportedly been used for the treatment of constipation, blood-diseases, leucodema, inflammation and urinary discharges. A number of ethnomedicinal records exist regarding the use of B. arundinaceae shoots as a laxative, however, there are no scientific studies reported on its laxative activity. Therefore, the aim of this present study was to evaluate the laxative activity of an ethanolic B...
December 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29219248/-my-mother-told-me-that-i-should-not-a-qualitative-study-exploring-the-restrictions-placed-on-adolescent-girls-living-with-hiv-in-zambia
#10
Constance Rs Mackworth-Young, Virginia Bond, Alison Wringe, Katongo Konayuma, Sue Clay, Chipo Chiiya, Mutale Chonta, Kirsty Sievwright, Anne L Stangl
INTRODUCTION: Adolescent girls in sub-Saharan Africa are disproportionately affected by HIV due to a range of social and structural factors. As they transition to adulthood, they are recipients of increasing blame for HIV infection and 'improper' sex, as well as increasing scrutiny, restrictions and surveillance. This study used a qualitative and participatory approach to explore the messaging and restrictions imposed on adolescent girls living with HIV in Zambia. METHODS: Thirty-four in-depth interviews and four participatory workshops were carried out with 24 adolescent girls aged 15 to 19 years old living with HIV in Lusaka, Zambia...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29214596/preparing-for-the-future-of-rare-diseases
#11
Stephen C Groft, Manuel Posada de la Paz
Members of the rare disease community have devoted significant financial and personnel resources to address the numerous issues surrounding rare diseases. The past has been devoted to developing an emphasis on rare diseases including an emphasis on research studies or locating information on rare diseases and the requirements and limitations of conducting clinical trials with small patient populations. The expanded role of patient advocacy organizations and patient engagement in all aspects of clinical research continues to gain acceptance within the research community...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29210555/improving-patient-safety-care-transitions
#12
Joshua Davis, Margot Savoy, Heather Bittner-Fagan
Care transitions are times of high risk of harm to patients. The transition from hospital care to outpatient care is perhaps the most well-studied transition and is encountered commonly in the family medicine setting. For discharge transitions, several hospital-based interventions for patients with major diagnoses have resulted in improvements in readmission rates, costs, and patient satisfaction. Prompt scheduling of a follow-up appointment with patients after discharge is crucial. Key issues to consider in the first post-discharge appointment include drug reconciliation and follow-up of any pending tests and results...
December 2017: FP Essentials
https://www.readbyqxmd.com/read/29210265/characterizing-the-switching-transitions-of-an-adsorbed-peptide-by-mapping-the-potential-energy-surface
#13
James A Ross-Naylor, Milan Mijajlovic, Hu Zhang, Mark J Biggs
Peptide adsorption occurs across technology, medicine and nature. The functions of adsorbed peptides are related to their conformation. In the past, molecular simulation methods such as molecular dynamics have been used to determine key conformations of adsorbed peptides. However, the transitions between these conformations often occur too slowly to be modeled reliably by such methods. This means such transitions are less well understood. In the study reported here, discrete path sampling is used for the first time to study the potential energy surface of an adsorbed peptide (polyalanine) and the transition pathways between various stable adsorbed conformations that have been identified in prior work by two of the authors (Mijajlovic, M...
December 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29209996/understanding-ownership-of-patient-care-a%C3%A2-dual-site-qualitative-study-of-faculty-and-residents-from-medicine-and-psychiatry
#14
Deborah S Cowley, Jesse D Markman, Jennifer A Best, Erica L Greenberg, Michael J Grodesky, Suzanne B Murray, Kelli A Corning, Mitchell R Levy, William E Greenberg
INTRODUCTION: With changes in duty hours and supervision requirements, educators have raised concerns about erosion of patient care ownership by resident physicians. However, the definition of ownership is unclear. This qualitative study investigated definitions of ownership in medicine and psychiatry faculty and residents. METHODS: The authors distributed an anonymous online survey regarding definitions of ownership to faculty and residents at the psychiatry and internal medicine residency programs at the University of Washington and the Harvard Longwood psychiatry residency and conducted a qualitative analysis of free-text responses to identify emergent themes...
December 5, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/29208032/junior-rounds-an-educational-initiative-to-improve-role-transitions-for-junior-residents
#15
Richard Dunbar-Yaffe, Wayne L Gold, Peter E Wu
OBJECTIVE: At our institution, Morning Report focuses mostly on diagnostic reasoning. This makes it a challenge for first-year residents to learn to manage common on-call emergencies, such as hyperkalemia. We sought to improve their preparedness for the transitions they would encounter: from medical student to physician at the beginning of the academic year, and from junior resident to senior resident toward the end. In response to feedback, we developed the Junior Rounds curriculum: a weekly session focused on the approach to commonly encountered on-call emergencies and internal medicine referrals...
December 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29206829/-transition-from-millennium-development-goals-to-sustainable-development-goals-from-the-perspective-of-the-social-determinants-of-health-and-health-equity
#16
Manue Urbina-Fuentes, Luis Jasso-Gutiérrez, Raffaela Schiavon-Ermani, Rafael Lozano, Jacobo Finkelman
The United Nations Declaration of 2000 agreed on eight millennium development goals (MDGs) to be met in 2015. The results show that poverty continues through population growth and advances in both rich and poor countries are threatened by economic crises and inequities in geographic areas and population groups within countries. In a globalized world with great social and economic inequalities, from the perspective of the social determinants of health (SDH), the relevance of the new 17 sustainable development goals (SDGs) is greater...
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29200059/a-perioperative-medicine-model-for-population-health-an-integrated-approach-for-an-evolving-clinical-science
#17
Solomon Aronson, Julie Westover, Nicole Guinn, Tracy Setji, Paul Wischmeyer, Padma Gulur, Thomas Hopkins, Thorsten M Seyler, Sandhya Lagoo-Deendayalan, Mitchell T Heflin, Annemarie Thompson, Madhav Swaminathan, Ellen Flanagan
Health care delivery in the United States continues to balance on the tight rope that connects its transition from volume to value. Value in economic terms can be defined as the amount something exceeds its commodity price and is determined by extraordinary reputation, quality, and/or service, whereas its destruction can be a consequence of poor management, unfavorable policy, decreased demand, and/or increased competition. Going forward, payment for health care delivery will increasingly be based on services that contribute to improvements in individual and/or population health value, and funds to pay for health care delivery will become increasingly vulnerable to competitive market forces...
November 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29199005/ginsenoside-rg3-sensitizes-hypoxic-lung-cancer-cells-to-cisplatin-via-blocking-of-nf-%C3%AE%C2%BAb-mediated-epithelial-mesenchymal-transition-and-stemness
#18
Jingjing Wang, Lili Tian, Muhammad Noman Khan, Li Zhang, Qun Chen, Yi Zhao, Qiu Yan, Li Fu, Jiwei Liu
Cisplatin is a first line chemotherapy in lung cancer, but decreased susceptibility may limit its application. In solid tumors, hypoxia alters the microenvironment and is associated with proliferation, metastasis, and drug sensitivity. The hypoxia-induced desensitization of cisplatin is not clearly elucidated. 20 (R)-Ginsenoside (Rg3), the traditional Chinese medicine, is extracted from ginseng and has antitumor activities. In this study, we evaluated if Rg3 is effective in improving cisplatin sensitivity by blocking hypoxia...
November 30, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29197305/internal-medicine-hospitalists-perceived-barriers-and-recommendations-for-optimizing-secondary-prevention-of-osteoporotic-hip-fractures
#19
Eng Keong Tan, Kah Poh Loh, Sarah L Goff
OBJECTIVES: Osteoporosis is a major public health concern affecting an estimated 10 million people in the United States. To the best of our knowledge, no qualitative study has explored barriers perceived by medicine hospitalists to secondary prevention of osteoporotic hip fractures. We aimed to describe these perceived barriers and recommendations regarding how to optimize secondary prevention of osteoporotic hip fracture. METHODS: In-depth, semistructured interviews were performed with 15 internal medicine hospitalists in a tertiary-care referral medical center...
December 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29195901/triptolide-suppresses-paraquat-induced-idiopathic-pulmonary-fibrosis-by-inhibiting-tgfb1-dependent-epithelial-mesenchymal-transition
#20
Hong Chen, Qun Chen, Chun-Ming Jiang, Guang-Yue Shi, Bo-Wen Sui, Wei Zhang, Li-Zhen Yang, Zhu-Ying Li, Li Liu, Yu-Ming Su, Wen-Cheng Zhao, Hong-Qiang Sun, Zhen-Zi Li, Zhou Fu
Idiopathic pulmonary fibrosis (IPF) and tumor are highly similar to abnormal cell proliferation that damages the body. This malignant cell evolution in a stressful environment closely resembles that of epithelial-mesenchymal transition (EMT). As a popular EMT-inducing factor, TGFβ plays an important role in the progression of multiple diseases. However, the drugs that target TGFB1 are limited. In this study, we found that triptolide (TPL), a Chinese medicine extract, exerts an anti-lung fibrosis effect by inhibiting the EMT of lung epithelial cells...
November 28, 2017: Toxicology Letters
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