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https://www.readbyqxmd.com/read/29027120/elucidating-the-preadipocyte-and-its-role-in-adipocyte-formation-a-comprehensive-review
#1
REVIEW
Christos N Sarantopoulos, Derek A Banyard, Mary E Ziegler, Beatrice Sun, Ashkaun Shaterian, Alan D Widgerow
Adipogenesis is a complex process whereby the multipotent adipose-derived stem cell is converted to a preadipocyte before terminal differentiation into the mature adipocyte. Preadipocytes are present throughout adult life, exhibit adipose fat depot specificity, and differentiate and proliferate from distinct progenitor cells. The mechanisms that promote preadipocyte commitment and maturation involve numerous protein factor regulators, epigenetic factors, and miRNAs. Detailed characterization of this process is currently an area of intense research and understanding the roles of preadipocytes in tissue plasticity may provide insight into novel approaches for tissue engineering, regenerative medicine and treating a host of obesity-related conditions...
October 13, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29025357/fatherhood-in-australian-aboriginal-and-torres-strait-islander-communities-an-examination-of-barriers-and-opportunities-to-strengthen-the-male-parenting-role
#2
Lyndon Reilly, Susan Rees
Traditional Australian Aboriginal and Torres Strait Islander societies value men's role as parents; however, the importance of promoting fatherhood as a key social determinant of men's well-being has not been fully appreciated in Western medicine. To strengthen the Aboriginal and Torres Strait Islander male parenting role, it is vital to examine current barriers and opportunities. The first author (a male Aboriginal health project officer) conducted yarning sessions in three remote Australian communities, two being Aboriginal, the other having a high Aboriginal population...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29024555/concise-review-tissue-engineering-of-urinary-bladder-we-still-have-a-long-way-to-go
#3
REVIEW
Jan Adamowicz, Marta Pokrywczynska, Shane Vontelin Van Breda, Tomasz Kloskowski, Tomasz Drewa
Regenerative medicine is a new branch of medicine based on tissue engineering technology. This rapidly developing field of science offers revolutionary treatment strategy aimed at urinary bladder regeneration. Despite many promising announcements of experimental urinary bladder reconstruction, there has been a lack in commercialization of therapies based on current investigations. This is due to numerous obstacles that are slowly being identified and precisely overcome. The goal of this review is to present the current status of research on urinary bladder regeneration and highlight further challenges that need to be gradually addressed...
October 10, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29024333/united-we-stand-divided-we-conquer-pilot-study-of-multidisciplinary-general-medicine-heart-failure-care-program
#4
Omar Wahbi Izzettin, Ingrid Hopper, Edward Ritchie, Vathy Nagalingam, Ar Kar Aung
BACKGROUND: Heart failure care and education require a multifaceted approach to ensure appropriate transition from inpatient to outpatient care. AIMS: To explore the feasibility of a multidisciplinary heart failure care model, General Medicine Heart Failure Care Program (GM-HFCP) within a General Medical Unit (GMU). METHODS: Prospective non-randomised before-and-after observational quality improvement intervention over a 6-month period. All consecutive patients admitted to GMU at Alfred Hospital with diagnosis of acute decompensated heart failure were included...
October 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29018797/micrornas-make-the-call-in-cancer-personalized-medicine
#5
REVIEW
Simone Detassis, Margherita Grasso, Valerio Del Vescovo, Michela A Denti
Since their discovery and the advent of RNA interference, microRNAs have drawn enormous attention because of their ubiquitous involvement in cellular pathways from life to death, from metabolism to communication. It is also widely accepted that they possess an undeniable role in cancer both as tumor suppressors and tumor promoters modulating cell proliferation and migration, epithelial-mesenchymal transition and tumor cell invasion and metastasis. Moreover, microRNAs can even affect the tumor surrounding environment influencing angiogenesis and immune system activation and recruitment...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29016418/improving-posthospital-discharge-telephone-reach-rates-through-prehospital-discharge-face-to-face-meetings
#6
Franz H Vergara, Daniel J Sheridan, Nancy J Sullivan, Chakra Budhathoki
PURPOSE OF THE STUDY: The purpose of this study was to determine whether a face-to-face meeting with patients by a telephonic case manager prehospital discharge would result in increased telephone follow-up (TFU) reach rates posthospital discharge. PRIMARY PRACTICE SETTING: Acute care adult medicine inpatient units. METHODOLOGY AND SAMPLE: A quasiexperimental design was utilized. Two adult inpatient medicine units were selected as the intervention and comparison groups...
November 2017: Professional Case Management
https://www.readbyqxmd.com/read/28994295/thermodynamics-of-polypeptide-supramolecular-assembly-in-the-short-chain-limit
#7
Thomas O Mason, Thomas C T Michaels, Aviad Levin, Christopher M Dobson, Ehud Gazit, Tuomas P J Knowles, Alexander K Buell
The self-assembly of peptides into ordered supramolecular structures, such as fibrils and crystals, is of relevance in such diverse areas as molecular medicine and materials science. However, little information is available about the fundamental thermodynamic driving forces of these types of self-assembly processes. Here we investigate in detail the thermodynamics of assembly of diphenylalanine. This dipeptide forms the central motif of the Aβ polypeptides which are associated with Alzheimer's disease through their presence in amyloid plaques in the nervous systems of affected individuals...
October 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28993030/a-maternal-functional-module-in-the-mammalian-oocyte-to-embryo-transition
#8
REVIEW
Xukun Lu, Zheng Gao, Dandan Qin, Lei Li
Prior to zygotic genome activation, early mammalian development relies on maternal-effect genes to orchestrate the oocyte-to-embryo transition. Recently, a subcortical maternal complex (SCMC) was identified to be essential for mouse preimplantation development. The SCMC integrates multiple proteins encoded by maternal-effect genes and appears to be functionally conserved across mammalian species. In addition, mutations in human SCMC genes are associated with certain human reproductive disorders. Here, we highlight recent advances in the biology of the SCMC and propose that this complex may be a representative example of maternal functional modules in mammalian oocyte-to-embryo transition...
October 6, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28992620/potential-ameliorative-effects-of-qing-ye-dan-against-cadmium-induced-prostatic-deficits-via-regulating-nrf-2-ho-1-and-tgf-%C3%AE-1-smad-pathways
#9
Lifen Du, Yongfang Lei, Jinglou Chen, Hongping Song, Xinying Wu
BACKGROUND/AIMS: Cadmium (Cd) is an environmental pollutant with reproductive toxicity. Swertia mileensis is used in Chinese medicine for the treatment of prostatic deficits and named as Qing Ye Dan (QYD). This study was undertaken to investigate the potential protective effects of QYD against Cd-induced prostatic deficits. METHOD: Rat model of prostatic deficits was induced by 0.2 mg/kg/d CdCl2 subcutaneous injection for 15 days. The prostatic oxidative stress was evaluated by detecting the levels of malondialdehyde, nitric oxide, reduced/ oxidized glutathione, total sulfhydryl groups and enzymatic antioxidant status...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28989294/what-are-the-educational-and-curriculum-needs-for-emergency-medical-technicians-in-taiwan-a-scoping-review
#10
REVIEW
Yu-Tung Chang, Kuang-Chau Tsai, Brett Williams
PURPOSE: The development of emergency medical services (EMS) training in Taiwan is in a transitional phase because of increasing demand for, and advancements in, clinical skill sets. The aim of this study is to review the current literature to compare the key factors of EMS training and education development in different countries in order to provide a new curricula blueprint for the Taiwanese EMS training system. METHOD: The method follows Arksey and O'Malley's six stages of scoping review...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28988037/cost-effectiveness-of-methods-in-personalized-medicine-results-of-a-decision-analytic-model-in-patients-with-acute-myeloid-leukemia-with-normal-karyotype
#11
Laura Hörster, Richard F Schlenk, Michael Stadler, Maria Gabriel, Felicitas Thol, Jan Schildmann, Jochen Vollmann, Ursula Rochau, Gaby Sroczynski, Jürgen Wasem, Arnold Ganser, Matthias Port, Anja Neumann
BACKGROUND: During the last years, molecular genetic data are increasingly used as prognostic and predictive factors in acute myeloid leukemia (AML). The molecular genetic profile permits a rapid risk categorization and beyond that a prediction of differential treatment efficacy of post-remission chemotherapy versus an allogeneic hematopoietic cell transplantation (HCT) in specific subgroups. METHODS: The aim of this study was to evaluate cost-effectiveness of two different strategies of risk categorization (conventional cytogenetic diagnostics (CCD) versus molecular genetic diagnostics (MGD)) in patients with AML, using a decision-analytic state-transition model...
September 19, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28985905/the-strategy-for-establishment-of-the-multiple-reaction-monitoring-based-characteristic-chemical-profile-of-triterpenes-in-alismatis-rhizoma-using-two-combined-tandem-mass-spectrometers
#12
Sen Li, Shuna Jin, Chengwu Song, Shuailong Jia, Yang Zhang, Yulin Feng, Zhifeng Du, Hongliang Jiang
It was reported that triterpenes compounds in Alismatis rhizoma (AR) contributed to the lipid lowering effect on high fat diet (HFD)-induced hyperlipidemia. To date only 24 triterpenes (including the isomers) were characterized by LC-QTOF-MS/MS due to the lack of strategies for systematic discovery, classification and identification of triterpenes in AR. In this study, an integrated strategy combining various QTOF-MS/MS and QTRAP-MS/MS scan functions was developed for systematic identification and specific characterization of triterpenes in AR and processed AR...
September 25, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28977822/blocking-epithelial-to-mesenchymal-transition-in-glioblastoma-with-a-sextet-of-repurposed-drugs-the-eis-regimen
#13
Richard E Kast, Nicolas Skuli, Georg Karpel-Massler, Guido Frosina, Timothy Ryken, Marc-Eric Halatsch
This paper outlines a treatment protocol to run alongside of standard current treatment of glioblastoma- resection, temozolomide and radiation. The epithelial to mesenchymal transition (EMT) inhibiting sextet, EIS Regimen, uses the ancillary attributes of six older medicines to impede EMT during glioblastoma. EMT is an actively motile, therapy-resisting, low proliferation, transient state that is an integral feature of cancers' lethality generally and of glioblastoma specifically. It is believed to be during the EMT state that glioblastoma's centrifugal migration occurs...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974636/an-interview-with-jayaraj-rajagopal
#14
Aidan Maartens
Jayaraj (Jay) Rajagopal is a Principal Investigator at the Center for Regenerative Medicine at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School. A Howard Hughes Medical Institute Faculty Scholar, his lab works on the development and regeneration of the lung. He uses stem cell and animal models to develop novel insights that hopefully will provide inspiration for therapies to help treat human lung disease. He was awarded the Dr Susan Lim Award for Outstanding Young Investigator at the 2017 International Society for Stem Cell Research (ISSCR) meeting in Boston (MA,USA), where we met him to talk about how a fish tank started a life-long fascination with the lung, the transition to running his own lab, and his optimism for the future of both basic stem cell research and its clinical translation...
October 1, 2017: Development
https://www.readbyqxmd.com/read/28972011/effective-activated-pi3k%C3%AE-syndrome-targeted-therapy-with-the-pi3k%C3%AE-inhibitor-leniolisib
#15
V Koneti Rao, Sharon Webster, Virgil A S H Dalm, Anna Šedivá, P Martin van Hagen, Steven Holland, Sergio D Rosenzweig, Andreas D Christ, Birgitte Sloth, Maciej Cabanski, Aniket D Joshi, Stefan de Buck, Julie Doucet, Danilo Guerini, Christoph Kalis, Ilona Pylvaenaeinen, Nicolas Soldermann, Anuj Kashyap, Gulbu Uzel, Michael J Lenardo, Dhavalkumar D Patel, Carrie L Lucas, Christoph Burkhart
Pathogenic gain-of-function variants in the genes encoding PI3Kδ (phosphoinositide 3-kinase delta) lead to accumulation of transitional B cells and senescent T cells, lymphadenopathy and immune-deficiency (Activated PI3Kδ Syndrome, APDS). Knowing the genetic etiology of APDS afforded us the opportunity to explore PI3Kδ inhibition as a precision-medicine therapy. Here, we report in vitro and in vivo effects of inhibiting PI3Kδ in APDS. Treatment with leniolisib (CDZ173), a selective PI3Kδ inhibitor, caused a dose-dependent suppression of PI3Kδ pathway hyperactivation (measured as phosphorylation of AKT/S6) in cell lines ectopically expressing APDS-causative p110δ variants and in T cell blasts derived from patients...
September 29, 2017: Blood
https://www.readbyqxmd.com/read/28971365/investigating-oral-absorption-of-carbamazepine-in-pediatric-populations
#16
Philip Kohlmann, Cordula Stillhart, Martin Kuentz, Neil Parrott
Prediction of the pharmacokinetics of orally administered drugs in children is of importance to optimize the efficacy and safety of pediatric medicines. Physiologically based pharmacokinetic (PBPK) models can be helpful for this purpose. However, application of these tools is limited by significant knowledge gaps regarding the physiological and anatomical changes which occur with age. This study aimed at investigating the age-dependent differences in oral absorption of a poorly soluble model compound, carbamazepine (CBZ) in children, infants, and neonates...
October 2, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28960923/surgery-for-constipation-systematic-review-and-practice-recommendations-results-i-colonic-resection
#17
REVIEW
C H Knowles, U Grossi, M Chapman, J Mason
AIM: To assess the outcomes of colectomy in adults with chronic constipation (CC). METHOD: Standardised methods and reporting of benefits and harms were used for all CapaCiTY reviews that closely adhered to PRISMA 2016 guidance. Main conclusions were presented as summary evidence statements (SES) with a summative Oxford Centre for Evidence-Based Medicine (2009) level. RESULTS: Forty articles were identified, providing data on outcomes in 2045 patients...
September 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28958512/physicochemical-and-viscoelastic-properties-of-honey-from-medicinal-plants
#18
Huong Thi Lan Nguyen, Naksit Panyoyai, Vilia Darma Paramita, Nitin Mantri, Stefan Kasapis
The present work investigated the physicochemical and structural properties of Tulsi, Alfalfa and two varieties of Manuka honey derived from medicinal plants. Chemical analysis yielded data on the content of reducing sugars (glucose and fructose) that dominate the honey matrix, and of the minor constituents of protein, phenols and flavonoids. Standard chemical assays were used to develop a database of water content, electrical conductivity, pH, ash content, visual appearance and colour intensity. Physicochemical characteristics were related to structural behaviour of the four honey types, as recorded by small-deformation dynamic oscillation in shear, micro- and modulated differential scanning calorimetry, wide angle X-ray diffraction and infrared spectroscopy...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28957627/an-automated-transition-state-search-and-its-application-to-diverse-types-of-organic-reactions
#19
Leif D Jacobson, Art D Bochevarov, Mark A Watson, Thomas F Hughes, David Rinaldo, Stephan Ehrlich, Thomas B Steinbrecher, S Vaitheeswaran, Dean M Philipp, Mathew D Halls, Richard A Friesner
Transition state search is at the center of multiple types of computational chemical predictions related to mechanistic investigations, reactivity and regioselectivity predictions, and catalyst design. The process of finding transition states in practice is however a laborious multistep operation that requires significant user involvement. Here we report a highly automated workflow designed to locate transition states for a given elementary reaction with a minimal setup overhead. The only essential inputs required from the user are the structures of the separated reactants and products...
September 28, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28952590/preparation-and-biocompatible-surface-modification-of-redox-altered-cerium-oxide-nanoparticle-promising-for-nanobiology-and-medicine
#20
Himansu Sekhar Nanda
The biocompatible surface modification of metal oxide nanoparticles via surface functionalization technique has been used as an important tool in nanotechnology and medicine. In this report, we have prepared aqueous dispersible, trivalent metal ion (samarium)-doped cerium oxide nanoparticles (SmCNPs) as model redox altered CNPs of biological relevance. SmCNP surface modified with hydrophilic biocompatible (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl) triethoxysilane (MEEETES) were prepared using ammonia-induced ethylene glycol-assisted precipitation method and were characterized using a variety of complementary characterization techniques...
November 3, 2016: Bioengineering
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