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https://www.readbyqxmd.com/read/29624527/dezocine-alleviates-morphine-induced-dependence-in-rats
#1
Fei-Xiang Wu, Hasan Babazada, Hao Gao, Xi-Ping Huang, Chun-Hua Xi, Chun-Hua Chen, Jin Xi, Wei-Feng Yu, Renyu Liu
BACKGROUND: Opioid dependence is a major public health issue without optimal therapeutics. This study investigates the potential therapeutic effect of dezocine, a nonaddictive opioid, in opioid dependence in rat models. METHODS: Dezocine was administered intraperitoneally to a morphine-dependent rat model to investigate its effect on withdrawal and conditioned place preference (CPP). Effect of dezocine on morphine withdrawal syndrome and CPP was analyzed using 2-way analysis of variance (ANOVA) followed by Tukey's post hoc test...
April 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29563235/haloperidol-ameliorates-androgen-induced-behavioral-deficits-in-developing-male-rats
#2
Chunxiao Qi, Xiaoming Ji, Guoliang Zhang, Yunxiao Kang, Yuanxiang Huang, Rui Cui, Shuangcheng Li, Huixian Cui, Geming Shi
The purpose of present study was to infer the potential effects of testosterone increase in some male-based childhood-onset neuropsychiatric disorders, such as Tourette syndrome. Thus, the influence of early postnatal androgen exposure upon the neurobehaviors and its possible neural basis were investigated in the study. Male pup rats received consecutive 14-day testosterone propionate (TP) subcutaneous injection from postnatal day (PND) 7. The TP treatment produced the hyperactive motor behavior and grooming behavior as well as the increased levels of dopamine, tyrosine hydroxylase and dopamine transporter in the mesodopaminergic system and the elevated levels of serotonin in the nucleus accumbens, without affecting the levels of glutamate, γ-aminobutyric acid, norepinephrine and histamine in the caudate putamen and nucleus accumbens of PND21 and PND49 rats...
March 21, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29472857/contributions-of-the-nucleus-accumbens-shell-in-mediating-the-enhancement-in-memory-following-noradrenergic-activation-of-either-the-amygdala-or-hippocampus
#3
Erin C Kerfoot, Cedric L Williams
The nucleus accumbens shell is a site of converging inputs during memory processing for emotional events. The accumbens receives input from the nucleus of the solitary tract (NTS) regarding changes in peripheral autonomic functioning following emotional arousal. The shell also receives input from the amygdala and hippocampus regarding affective and contextual attributes of new learning experiences. The successful encoding of affect or context is facilitated by activating noradrenergic systems in either the amygdala or hippocampus...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29455417/effect-of-yulangsan-polysaccharide-on-the-reinstatement-of-morphine-induced-conditioned-place-preference-in-sprague-dawley-rats
#4
Chunxia Chen, Zhihuan Nong, Xingmei Liang, Mingyu Meng, Feifei Xuan, Qiuqiao Xie, Junhui He, Renbin Huang
We previously reported that Yulangsan polysaccharide (YLSP), which was isolated from the root of Millettia pulchra Kurz, attenuates withdrawal symptoms of morphine dependence by regulating the nitric oxide pathway and modulating monoaminergic neurotransmitters. In this study, we investigated the effects and mechanism of YLSP on the reinstatement of morphine-induced conditioned place preference (CPP) in rats. A CPP procedure was employed to assess the behavior of rats, and indicators of serum and four brain regions (nucleus accumbens, ventral tegmental area, hippocampus and prefrontal cortex) were determined to explore its underlying mechanism...
April 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29434542/norepinephrine-in-the-medial-pre-frontal-cortex-supports-accumbens-shell-responses-to-a-novel-palatable-food-in-food-restricted-mice-only
#5
Emanuele Claudio Latagliata, Stefano Puglisi-Allegra, Rossella Ventura, Simona Cabib
Previous findings from this laboratory demonstrate: (1) that different classes of addictive drugs require intact norepinephrine (NE) transmission in the medial pre Frontal Cortex (mpFC) to promote conditioned place preference and to increase dopamine (DA) tone in the nucleus accumbens shell (NAc Shell); (2) that only food-restricted mice require intact NE transmission in the mpFC to develop conditioned preference for a context associated with milk chocolate; and (3) that food-restricted mice show a significantly larger increase of mpFC NE outflow then free fed mice when experiencing the palatable food for the first time...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29313212/hyperbaric-oxygen-attenuates-withdrawal-symptoms-by-regulating-monoaminergic-neurotransmitters-and-no-signaling-pathway-at-nucleus-accumbens-in-morphine-dependent-rats
#6
Chunxia Chen, Qiuping Fan, Zhihuan Nong, Wan Chen, Yaoxuan Li, Luying Huang, Daorong Feng, Xiaorong Pan, Shengyong Lan
In this study, we examined whether hyperbaric oxygen (HBO2 ) plays a detoxification role in withdrawal symptoms in a morphine-dependent rat model. The model was established through injections of morphine at increasing doses for 7 days. Withdrawal symptoms were induced by naloxone injection on the 8th day. The detoxification effect of HBO2 was evaluated using the withdrawal symptom scores, biochemical indices and neurotransmitters. Compared with the model group, HBO2 therapy significantly attenuated the withdrawal symptom scores, body weight loss and the level of norepinephrine level, whereas it increased the dopamine level and tyrosine hydroxylase expression in the nucleus accumbens...
March 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29229557/%C3%AE-1b-adrenergic-receptor-localization-and-relationship-to-the-d1-dopamine-receptor-in-the-rat-nucleus-accumbens
#7
Darlene A Mitrano, Kelsey Jackson, Samantha Finley, Allison Seeley
The α1-adrenergic receptors (α1ARs) have been implicated in numerous actions of the brain, including attention and wakefulness. Additionally, they have been identified as contributing to disorders of the brain, such as drug addiction, and recent work has shown a role of these receptors in relapse to psychostimulants. While some functionality is known, the actual subcellular localization of the subtypes of the α1ARs remains to be elucidated. Further, their anatomical relationship to receptors for other neurotransmitters, such as dopamine (DA), remains unclear...
February 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29161023/the-in-vivo-neurochemical-profile-of-selectively-bred-high-responder-and-low-responder-rats-reveals-baseline-cocaine-evoked-and-novelty-evoked-differences-in-monoaminergic-systems
#8
Omar S Mabrouk, John L Han, Jenny-Marie T Wong, Huda Akil, Robert T Kennedy, Shelly B Flagel
Relative to bred low-responder (bLR) rats, bred high-responder (bHR) rats have an exaggerated locomotor response to a novel environment, take more risks, are more impulsive, and more likely to exhibit compulsive drug-seeking behaviors. These phenotypic differences in addiction-related behaviors and temperament have previously been associated with differences in neurotransmitter signaling, including the mesolimbic dopamine system. In this study, we applied advanced in vivo microdialysis sampling in the nucleus accumbens of bHRs and bLRs to assess differences in basal and stimulated neurochemical efflux more broadly...
December 12, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29129597/cocaine-and-desipramine-elicit-distinct-striatal-noradrenergic-and-behavioral-responses-in-selectively-bred-obesity-resistant-and-obesity-prone-rats
#9
Peter J Vollbrecht, Kathryn M Nesbitt, Omar S Mabrouk, Aaron M Chadderdon, Emily M Jutkiewicz, Robert T Kennedy, Carrie R Ferrario
Previous studies have demonstrated a role for norepinephrine (NE) in energy regulation and feeding, and basal differences have been observed in hypothalamic NE systems in obesity-prone vs. obesity-resistant rats. Differences in the function of brain reward circuits, including in the nucleus accumbens (NAc), have been shown in obesity-prone vs. obesity-resistant populations, leading many researchers to explore the role of striatal dopamine in obesity. However, alterations in NE transmission also affect NAc mediated behaviors...
July 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29118201/inflow-of-oxygen-and-glucose-in-brain-tissue-induced-by-intravenous-norepinephrine-relationships-with-central-metabolic-and-peripheral-vascular-responses
#10
R Aaron Bola, Eugene A Kiyatkin
As an essential part of sympathetic activation that prepares the organism for "fight or flight," peripheral norepinephrine (NE) plays an important role in regulating cardiac activity and the tone of blood vessels, increasing blood flow to the heart and the brain and decreasing blood flow to the organs not as necessary for immediate survival. To assess whether this effect is applicable to the brain, we used high-speed amperometry to measure the changes in nucleus accumbens (NAc) levels of oxygen and glucose induced by intravenous injections of NE in awake freely moving rats...
February 1, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28889722/effects-of-central-fibroblast-growth-factor-21-fgf21-in-energy-balance
#11
L Recinella, S Leone, C Ferrante, A Chiavaroli, C Di Nisio, S Martinotti, M Vacca, L Brunetti, G Orlando
Fibroblast growth factor 21 (FGF21) is known as a major metabolic regulator of glucose and lipid homeostasis. Continuous intracerebroventricular (i.c.v.) administration of FGF21 was found to modulate feeding and energy expenditure in rats with diet-induced obesity, suggesting a central effect by the peptide. In this context, in the present work, we studied the effects of a single central FGF21 administration (0.5-5 µg) on feeding and energy expenditure by evaluating locomotor activity, interscapular brown adipose tissue (BAT) weight, gene expression of uncoupling protein-1 (UCP-1) in BAT and plasma norepinephrine (NE) levels in Sprague-Dawley fed rats...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28857746/purinergic-regulation-of-brain-catecholamine-neurotransmission-in-vivo-electrophysiology-and-microdialysis-study-in-rats
#12
Eliyahu Dremencov, Lubica Lacinova, Gunnar Flik, Joost Ha Folgering, Thomas Ifh Cremers, Ben Hc Westerink
It was previously reported that adenosine-2A (A2A) receptors interact with dopamine-2 (D2) receptors on a molecular level. The aim of the current study was to investigate the functional output of this interaction. In vivo microdialysis was used to assess the effects of an antagonist of A2A receptors, ZM 241385, and an antagonist of D2 receptors haloperidol, either alone or in combination, on brain catecholamine levels. It was found that ZM 241385 did not alter catecholamine levels by its own, but potentiated haloperidol-induced dopamine and norepinephrine release in the nucleus accumbens and prefrontal cortex, respectively...
October 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28802898/neurochemical-evidence-that-cocaine-and-amphetamine-regulated-transcript-cart-55-102-peptide-modulates-the-dopaminergic-reward-system-by-decreasing-the-dopamine-release-in-the-mouse-nucleus-accumbens
#13
Angelina Rakovska, Maria Baranyi, Katalin Windisch, Polina Petkova-Kirova, Hristo Gagov, Reni Kalfin
CART (Cocaine- and Amphetamine-Regulated Transcript) peptide is a neurotransmitter naturally occurring in the CNS and found mostly in nucleus accumbens, ventrotegmental area, ventral pallidum, amygdalae and striatum, brain regions associated with drug addiction. In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28594540/noradrenergic-modulation-of-dopamine-transmission-evoked-by-electrical-stimulation-of-the-locus-coeruleus-in-the-rat-brain
#14
Jin W Park, Rohan V Bhimani, Jinwoo Park
Central norepinephrine (NE) and dopamine (DA) are involved in a variety of physiological functions and behaviors. Accumulating evidence suggests that NE neurons originating from the locus coeruleus (LC) innervate DA neurons of the ventral tegmental area (VTA) and influence VTA-DA neural activity. However, the underlying mechanisms of how LC-NE regulates DA transmission via VTA-DA neurons remain largely unexplored. Herein, we investigated how electrical stimulation of the LC modulates VTA-DA neurotransmission in the nucleus accumbens (NAc)...
June 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28537967/nortriptyline-enhances-morphine-conditioned-place-preference-in-neuropathic-rats-role-of-the-central-noradrenergic-system
#15
Wenli Mi, Shuxing Wang, Zerong You, Grewo Lim, Michael F McCabe, Hyangin Kim, Lucy Chen, Jianren Mao
BACKGROUND: Combination drug therapy is commonly used to treat chronic pain conditions such as neuropathic pain, and antidepressant is often used together with opioid analgesics. While rewarding is an intrinsic property of opioid analgesics, it is unknown whether the use of an antidepressant would influence opioid reward, which may contribute to opioid addiction. In this study, we examined whether nortriptyline (a tricyclic antidepressant and a first-line medication for neuropathic pain) would enhance the morphine rewarding property in both naive and chronic constriction sciatic nerve injury (CCI) rats...
September 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28474759/a-simple-and-sensitive-high-performance-liquid-chromatography-electrochemical-detection-assay-for-the-quantitative-determination-of-monoamines-and-respective-metabolites-in-six-discrete-brain-regions-of-mice
#16
Serena A Allen, Stephanie Rednour, Samantha Shepard, Brooks Barnes Pond
A rapid, sensitive, and reproducible assay is described for the quantitative determination of the monoamine neurotransmitters dopamine, norepinephrine and serotonin, their metabolites, and the internal standard 3,4-dihydroxybenzlyamine hydro-bromide in mouse brain homogenate using high-performance liquid chromatography with electrochemical detection. The method was validated in the following brain areas: frontal cortex, striatum, nucleus accumbens, hippocampus, substantia nigra pars compacta and ventral tegmental area...
November 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28392265/norepinephrine-regulates-cocaine-primed-reinstatement-via-%C3%AE-1-adrenergic-receptors-in-the-medial-prefrontal-cortex
#17
Karl T Schmidt, Jason P Schroeder, Stephanie L Foster, Katherine Squires, Brilee M Smith, Elizabeth G Pitts, Michael P Epstein, David Weinshenker
Drug-primed reinstatement of cocaine seeking in rats is thought to reflect relapse-like behavior and is mediated by the integration of signals from mesocorticolimbic dopaminergic projections and corticostriatal glutamatergic innervation. Cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine β-hydroxylase (DBH) inhibitors, which prevent norepinephrine (NE) synthesis, or by α1-adrenergic receptor (α1AR) antagonists, indicating functional modulation by the noradrenergic system...
June 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28219751/evidence-for-a-role-of-corticopetal-noradrenergic-systems-in-the-development-of-executive-function
#18
REVIEW
David J Mokler, Christine E Miller, Jill A McGaughy
Adolescence is a period during which many aspects of executive function are maturing. Much of the literature has focused on discrepancies between sub-cortical and cortical development that is hypothesized to lead to over-processing of reinforcement related stimuli unchecked by fully matured response inhibition. Specifically, maturation of sub-cortical dopaminergic systems that terminate in the nucleus accumbens has been suggested to occur prior to the full maturation of corticopetal dopaminergic systems. However, converging evidence supports the hypothesis that many aspects of cognitive control are critically linked to cortical noradrenergic systems, that the effectiveness of drugs used to treat disorders of executive function, e...
September 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27866999/the-5-ht1a-1b-receptor-agonist-eltoprazine-increases-both-catecholamine-release-in-the-prefrontal-cortex-and-dopamine-release-in-the-nucleus-accumbens-and-decreases-motivation-for-reward-and-waiting-impulsivity-but-increases-stopping-impulsivity
#19
S Mechiel Korte, Jolanda Prins, Filip S Van den Bergh, Ronald S Oosting, Rudy Dupree, Gerdien A H Korte-Bouws, Koen G C Westphal, Berend Olivier, Damiaan A Denys, Alexis Garland, Onur Güntürkün
The 5-HT1A/1B-receptor agonist eltoprazine has a behavioral drug signature that resembles that of a variety of psychostimulant drugs, despite the differences in receptor binding profile. These psychostimulants are effective in treating impulsivity disorders, most likely because they increase norepinephrine (NE) and dopamine (DA) levels in the prefrontal cortex. Both amphetamine and methylphenidate, however, also increase dopamine levels in the nucleus accumbens (NAc), which has a significant role in motivation, pleasure, and reward...
January 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27646482/evidence-that-activation-of-nuclear-peroxisome-proliferator-activated-receptor-alpha-ppar%C3%AE-modulates-sleep-homeostasis-in-rats
#20
Eric Murillo-Rodríguez, Khalil Guzmán, Gloria Arankowsky-Sandoval, Mireille Salas-Crisóstomo, Ramsés Jiménez-Moreno, Oscar Arias-Carrión
The peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor superfamily that has been suggested as a modulator of several physiological functions. The PPARα recognizes as an endogenous ligand the anorexic lipid mediator oleoylethanolamide (OEA) which displays wake-inducing properties. Despite that recent evidence indicates that activation of PPARα by synthetic agonists such as Wy14643 enhances waking as well as the extracellular contents of wake-related neurotransmitters, the role of PPARα in sleep recovery after prolonged waking has not been fully described...
October 2016: Brain Research Bulletin
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