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https://www.readbyqxmd.com/read/29755747/structural-studies-of-crystalline-forms-of-triamterene-with-carboxylic-acid-gras-and-api-molecules
#1
Abida Rehman, Amit Delori, David S Hughes, William Jones
Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative crystallization. The modified Δp K a rule as proposed by Cruz-Cabeza [(2012 ▸). CrystEngComm , 14 , 6362-6365] is in close agreement with the results of this study. All adducts were characterized by X-ray diffraction and thermal analytical techniques, including single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry and thermal gravimetric analysis...
May 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29750033/dna-and-rna-binding-ability-of-oligodapt-a-nucleobase-decorated-peptide-for-biomedical-applications
#2
Domenica Musumeci, Valentina Roviello, Giovanni N Roviello
Background: Nucleobase-bearing peptides and their interaction with DNA and RNA are an important topic in the development of therapeutic approaches. On one hand, they are highly effective for modulating the nucleic-acid-based biological processes. On the other hand, they permit to overcome some of the main factors limiting the therapeutic efficacy of natural oligonucleotides, such as their rapid degradation by nucleases. Methods and results: This article describes the synthesis and characterization of a novel thymine-bearing nucleoamino acid based on the l-diaminopropionic acid (l-Dap) and its solid phase oligomerization to α-peptides (oligoDapT), characterized using mass spectrometry, spectroscopic techniques, and scanning electron microscopy (SEM) analysis...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29735259/medical-therapy-for-asymptomatic-patients-and-stent-placement-for-symptomatic-patients-presenting-with-carotid-artery-near-occlusion-with-full-collapse
#3
Celso Ricardo Bregalda Neves, Ivan Benaduce Casella, Erasmo Simão da Silva, Pedro Puech-Leão
PURPOSE: To report long-term results of stent placement and medical therapy for symptomatic and asymptomatic patients, respectively, with carotid artery near-occlusion with full collapse. MATERIALS AND METHODS: Between January 2008 and December 2010, 204 carotid arteries diagnosed by duplex scanning as exhibiting complete occlusion were re-examined with CT angiography; 46 arteries in 46 patients were patent with threadlike lumens and were reclassified as exhibiting near-occlusion with full collapse...
May 5, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29725567/one-stage-stent-assisted-coil-embolization-for-rupture-side-unknown-bilateral-vertebral-artery-dissecting-aneurysms-in-an-acute-stage-a-case-report
#4
Mio Terashima, Yoichi Miura, Fujimaro Ishida, Naoki Toma, Tomohiro Araki, Shinichi Shimosaka, Kenji Kanamaru, Hidenori Suzuki
Bilateral vertebral artery dissecting aneurysms (VADAs) with subarachnoid hemorrhage (SAH) are rare and their management is still challenging. In this report, we successfully performed one-stage stent-assisted coil embolization (SAC) for bilateral VADAs with SAH in an acute stage, because the ruptured side could not be diagnosed. A 47-year-old woman presented with a sudden onset of headache without laterality, and left-side dominant SAH with bilateral VADAs was noted on computed tomography (CT) scans. The size of aneurysmal dome and neck was similar between the two VADAs, and a bleb was observed only on the right VADA...
April 2018: NMC Case Report Journal
https://www.readbyqxmd.com/read/29701379/which-aneurysm-characteristics-predict-evar-nonsuccess
#5
Pedro Pinto Sousa, Pedro Brandão, Alexandra Canedo
INTRODUCTION: Hostile anatomic characteristics in patients undergoing endovascular abdominal aortic aneurysm repair (EVAR) may lead to technical nonsuccess of the procedure, late complications, reintervention or death. The authors analyzed anatomical abdominal aortic aneurysm specific considerations so as technical endoprosthesis implantation and correlate them with endoleak development and postoperative survival. METHODS: Authors retrospectively reviewed all consecutive, elective, EVAR's that occurred between 2010 and 2016, with available data, at one institution for abdominal, infra renal, aortic aneurysms...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701344/median-arcuate-ligament-syndrome-literature-review-and-case-report
#6
Nelson Camacho, Gonçalo Alves, Frederico Bastos Gonçalves, Rodolfo Abreu, Rita Ferreira, Joana Catarino, Ricardo Correia, Rita Bento, Maria Emília Ferreira
INTRODUCTION: Median arcuate ligament syndrome (MALS) or Dunbar syndrome is a rare clinical entity characterized by celiac trunk compression by median arcuate ligament and variable gastrointestinal symptoms (postprandial epigastric pain, nausea, weight loss, anorexia and diarrhea). However, some degree of radiographic compression is observed in 10%-24% of asymptomatic patients. Besides the extrinsic vascular compression, MALS has a multifactorial etiology and it has been suggested as a neurogenic disease resulting in altered sensation and pain from the somatic nerves in the splanchnic plexus...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29688214/-extracranial-aneurysms-of-carotid-arteries-in-the-practice-of-a-vascular-surgeon
#7
R N Lar'kov, S S Zagarov, M V Vishniakova, R V Shilov
The present study was aimed at retrospectively analysing the results of examination and open surgical treatment of patients diagnosed with extracranial aneurysms of carotid arteries. PATIENTS AND METHODS: We analysed the results of examination and outcomes of surgical treatment in a total of 11 patients (6 men and 5 women) presenting with an aneurysm of the extracranial portion of the carotid artery and undergoing treatment at the Department of Vascular and CAD Surgery of the Moscow Regional Research Clinical Institute from 2005 to 2016...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29688203/-functional-assessment-of-primary-lesion-of-the-great-saphenous-vein-when-deciding-upon-stripping
#8
Iu T Tsukanov, A Iu Tsukanov
The purpose of the study was to examine a possibility of functional assessment of the great saphenous vein (GSV) with the help of a day orthostatic loading test for prognosis of restoration of the function of the GSV afterremoving its varicose tributaries in patients with primary varicose veins. Our prospective study included a total of sixty-five 29-to-53-year-old patients (15 men and 50 women, mean age - 36.7 years). The total number of the lower limb examined amounted to 87. All patients underwent ultrasonographic examination (duplex scanning) prior to operation, 1 and 12 months thereafter...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29688195/preoperative-and-intraoperative-assessment-of-volumetric-blood-flow-velocity-through-the-internal-thoracic-artery-in-patients-with-cad
#9
V V Bazylev, F L Bartosh, S V Sivushchina, A I Mikuliak
The left internal thoracic artery (ITA) is currently an artery of choice for revascularization of coronary arteries. Ultrasonographic duplex scanning (USDS) and ultrasound Doppler flowmetry (UDF) are sequential techniques to control patency of the ITA at stages of rendering care for patients on restoring coronary blood flow. We compared two methods of measuring the volumetric blood flow velocity: by means of USDS and UDF. The obtained results were statistically processed. It was determined that transthoracic USDS and intraoperative UDF in the assessment of the volumetric blood velocity through the ITA in patients with coronary artery disease are comparable methods, provided the patients have similar parameters of central haemodynamics...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29683433/a-case-of-symptomatic-popliteal-vein-aneurysm
#10
Roberta Garbuglio, Davide Turchino, Anna Maria Giribono, Luca Del Guercio, Umberto Marcello Bracale
We describe a case of a 44 year-old man with a subcutaneous swelling in the left popliteal fossa. The patient complained pain posteriorly to the left knee since several months and presented with a saccular aneurysm of the left popliteal vein (PVA) with reflux clearly evidenced at duplex ultrasound scan (DUS), but in absence of thrombus inside and without clinical signs of embolism. The patient was treated surgically by aneurysmectomy with lateral venorrhaphy according to Aldridge technique and a duplex ultrasound scan after six months revealed a complete patency of the left popliteal vein...
April 20, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29681458/characterization-of-profunda-femoris-vein-thrombosis
#11
Tana L Repella, Olga Lopez, Cherrie Z Abraham, Amir F Azarbal, Timothy K Liem, Erica L Mitchell, Gregory J Landry, Gregory L Moneta, Enjae Jung
OBJECTIVE: The incidence of and risk factors for profunda femoris vein (PFV) thrombosis are poorly characterized. We prospectively identified patients with PFV deep venous thrombosis (DVT) to characterize the demographics and anatomic distribution of proximal DVT in patients with PFV DVT. METHODS: A prospective study was conducted of patients at a tertiary care university hospital with DVT diagnosed by venous duplex ultrasound scanning between June 2014 and June 2015...
April 19, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29678687/clinical-characteristics-and-outcomes-of-patients-with-multiple-simultaneous-superficial-vein-thrombi
#12
Rishi Chopra, Luis R Leon, Nicos Labropoulos
BACKGROUND: Although unprovoked superficial venous thrombosis (SVT) has traditionally been considered a local, benign disorder, recent studies demonstrate that patients with SVT are at significant risk for deep venous thrombosis, pulmonary embolism, and other venous thromboembolism (VTE) events. Nevertheless, clinical management remains widely inconsistent. Moreover, patients with multiple, unprovoked SVTs of noncommunicating anatomic sites have not been previously described, and they may be at even increased risk for adverse outcomes...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29678685/success-rate-and-factors-predictive-of-redo-radiofrequency-ablation-of-perforator-veins
#13
Afsha Aurshina, Enrico Ascher, Lauren Mount, Amrit Hingorani, Natalie Marks, Anil Hingorani
OBJECTIVE: Radiofrequency ablation (RFA) is increasingly being employed for treatment of perforator vein insufficiency and venous ulcer healing. Previous studies have shown a closure rate of 60% to 80% in incompetent perforator veins (IPVs) with RFA. The purpose of the study was to determine the utility of a redo RFA for symptomatic recanalized perforators and to predict factors associated with recanalization. METHODS: A retrospective analysis of 642 procedures in 256 patients with venous insufficiency due to IPVs from 2009 to 2015 was conducted...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29678650/femoseal%C3%A2-device-use-for-femoral-artery-closure-by-different-techniques
#14
Roberto Gabrielli, Maria Sofia Rosati, Massiliano Millarelli, Angelica Dante, Maurizio Maiorano, Aldo Musilli, Roberto Chiappa, Marco Ventura
BACKGROUND: Common femoral artery is still the most frequently site used for vascular access, mostly for peripheral arterial interventions and its puncture remains a significant source of patient's morbidity. Manual compression (MC) has been the gold standard for hemostasis after femoral catheterization until recently, but only in the last few years, vascular closure devices (VCDs) are replacing MC due to their rapid development. Nowadays also vascular surgeons are becoming familiar with VCDs...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29677871/re-unreliability-of-the-duplex-scan-in-diagnosing-corporeal-venous-occlusive-disease-in-young-healthy-men-with-erectile-deficiency
#15
Allen D Seftel
No abstract text is available yet for this article.
May 2018: Journal of Urology
https://www.readbyqxmd.com/read/29673811/endovascular-aortic-repair-follow-up-protocol-based-on-contrast-enhanced-ultrasound-is-safe-and-effective
#16
Emiliano Chisci, Linda Harris, Azzurra Guidotti, Angelica Pecchioli, Clara Pigozzi, Enrico Barbanti, Leonardo Ercolini, Stefano Michelagnoli
OBJECTIVES: The aim of this study was to define the safety and effectiveness of a contrast enhanced ultrasound (CEUS) based follow up for endovascular aortic repair (EVAR) surveillance at a mid-term period (4 years). METHODS: At the tertiary referral centre EVAR surveillance was based on plain abdominal radiograph and duplex ultrasound (CDU), with computed tomography angiography (CTA) reserved for any non-diagnostic imaging during the period 1999-2011 (Group A)...
April 17, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29658209/upper-extremity-deep-vein-thrombosis-symptoms-diagnosis-and-treatment
#17
REVIEW
Jaber Mustafa, Ilan Asher, Zev Sthoeger
Upper extremity deep vein thrombosis (UEDVT) is defined as thrombosis of the deep venous system (subclavian, axillary, brachial, ulnar, and radial veins), which drains the upper extremities. It can be caused by thoracic outlet anatomic obstruction, such as Paget-Schroetter syndrome, (primary) or by central intravenous catheters (secondary). UEDVT may be asymptomatic or present with acute severe pain and arm swelling. Clinical suspicion should be confirmed by diagnostic imaging procedures such as duplex ultrasound, computed tomography scan, or magnetic resonance imaging...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29655813/synovial-chondromatosis-in-patient-presenting-with-chronic-venous-stasis-ulcers
#18
Christina Herrero, Charlotte Lemmens, Jan Sloves, Nirmal Tejwani, Thomas S Maldonado
Synovial Chondromatosis (SC) is a rare, benign synovial growth most frequently involving the knee or hip joint. Common presenting symptoms include pain throughout the affected joint, reduced range of motion and a palpable mass. We present an unusual case of SC presenting with symptoms of chronic venous stasis ulcer. A 49-year-old patient presented with swelling, hyperpigmentation and ulcerations of his right lower extremity. Work-up including duplex and CT scan revealed a calcified mass in the hip joint, highly suspicious for Synovial Chondromatosis...
April 12, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29626305/prevalence-and-predictors-of-preoperative-venous-thromboembolism-in-asymptomatic-patients-undergoing-major-oncologic-surgery
#19
Melanie L Gainsbury, Jennifer Erdrich, Dani Taubman, James Mirocha, Nicholas Manguso, Farin Amersi, Allan W Silberman
BACKGROUND: Postoperative venous thromboembolism (VTE) is a leading cause of in-hospital mortality for cancer patients; however, the prevalence of preoperative VTE remains unclear. OBJECTIVE: The aim of this study was to evaluate the prevalence and risk factors associated with preoperative VTE in asymptomatic patients undergoing major oncologic surgery. METHODS: Retrospective analysis of 346 patients identified from our prospectively maintained database of patients undergoing abdominopelvic oncologic surgery from 2009 to 2016...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29615450/prospective-single-uk-centre-comparative-study-of-the-predictive-values-of-contrast-enhanced-ultrasound-compared-to-time-resolved-ct-angiography-in-the-detection-and-characterisation-of-endoleaks-in-high-risk-patients-undergoing-endovascular-aneurysm-repair
#20
Iain Nicholas Roy, Tze Yuan Chan, Gabriela Czanner, Steve Wallace, Srinivasa Rao Vallabhaneni
INTRODUCTION: Diagnosis of endoleaks is imperative to prevent failure of endovascular aneurysm repairs (EVARs). The gold standard for diagnosis of endoleaks is catheter-directed subtraction angiography, which is not a practicable choice for surveillance. CT angiography (CTA) is the historical surveillance modality of choice. Concerns over cost, potential nephrotoxicity of contrast agents and repeated radiation exposure led to colour duplex ultrasound scan (CDUS) becoming an established alternative...
April 3, 2018: BMJ Open
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