Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Robert Herold, Claudia Terschüren, Wing-Yee Lo, Pascal Guénel, Thérèse Truong, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Irene L Andrulis, Hermann Brenner, Jenny Chang-Claude, Angela Cox, Simon S Cross, Kamila Czene, Mikael Eriksson, Jonine D Figueroa, Montserrat García-Closas, Mark S Goldberg, Ute Hamann, Wei He, Bernd Holleczek, John L Hopper, Anna Jakubowska, Yon-Dschun Ko, Jan Lubiński, Anna Marie Mulligan, Nadia Obi, Valerie Rhenius, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C Southey, Wei Zheng, Alison M Dunning, Paul D P Pharoah, Per Hall, Douglas F Easton, Thomas Brüning, Hiltrud Brauch, Volker Harth, Sylvia Rabstein
Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls)...
October 3, 2023: European Journal of Epidemiology