keyword
https://read.qxmd.com/read/37958845/neuromodulators-as-interdomain-signaling-molecules-capable-of-occupying-effector-binding-sites-in-bacterial-transcription-factors
#21
JOURNAL ARTICLE
Yuri A Purtov, Olga N Ozoline
Hormones and neurotransmitters are important components of inter-kingdom signaling systems that ensure the coexistence of eukaryotes with their microbial community. Their ability to affect bacterial physiology, metabolism, and gene expression was evidenced by various experimental approaches, but direct penetration into bacteria has only recently been reported. This opened the possibility of considering neuromodulators as potential effectors of bacterial ligand-dependent regulatory proteins. Here, we assessed the validity of this assumption for the neurotransmitters epinephrine, dopamine, and norepinephrine and two hormones (melatonin and serotonin)...
November 1, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37956180/retraction-sudden-infant-death-syndrome-melatonin-serotonin-and-cd34-factor-as-possible-diagnostic-markers-and-prophylactic-targets
#22
(no author information available yet)
No abstract text is available yet for this article.
2023: PloS One
https://read.qxmd.com/read/37945913/effects-of-melatonin-intake-on-depression-and-anxiety-in-postmenopausal-women-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#23
JOURNAL ARTICLE
Ahsen Demirhan Kayacik, Kevser İlcioglu
We conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) evaluating the effects of melatonin intake on depression and anxiety in postmenopausal women. To identify RCTs examining the effect of melatonin supplementation on depression and anxiety scores in postmenopausal women, a comprehensive electronic search was conducted via the Cochrane Central Register of Controlled Trials, Science direct, Google Scholar, PubMed, Medline, Scopus and Web of Science databases using the keywords ("melatonin" OR "N-acetyl serotonin") AND ("menopause" OR "climacteric") AND ("depression" OR "anxiety")...
November 9, 2023: Archives of Women's Mental Health
https://read.qxmd.com/read/37929993/melatonin-disturbed-rumen-microflora-structure-and-metabolic-pathways-in-vitro
#24
JOURNAL ARTICLE
Chun Xue, Yifan Wang, Zhaoyuan He, Zhiqi Lu, Feifan Wu, Yusu Wang, Yongkang Zhen, Jimeng Meng, Khuram Shahzad, Kailun Yang, Mengzhi Wang
Melatonin (MLT) can affect the microbial community structure and its metabolites by releasing cellular regulatory factors. Intestinal bacteria recognize and respond to MLT signals from the intestine through MLT binding sites and further activate the function of intestinal immune cells. However, the signal transduction pathway of MLT in the intestine has not been clearly elucidated yet. The effect of MLT on rumen bacterial metabolism was studied by simulating rumen fermentation in vitro . The test was divided into three groups: artificial saliva+standard MLT solution (CK0 group), artificial saliva+rumen juice (CK1 group), and artificial saliva+rumen juice+standard MLT solution (MLT group)...
November 6, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37929912/-properties-of-milk-in-sleep-induction
#25
JOURNAL ARTICLE
Rosa M Ortega, Ana Isabel Jiménez-Ortega, Rosa M Martínez García, Adrián Cervera-Muñoz, María Dolores Salas-González
Sleep induction and its quality are issues of growing concern because its deterioration affects a large number of people and poses a risk to their well-being and quality of life and long-term health. There are several factors involved in the problem, but nutrition is one of them and in particular milk consumption has often been linked to sleep habits, sometimes as a promoter and sometimes as an inhibitor. The purpose of this review is to examine the matter further. On reaching the brain, tryptophan is the basis for the synthesis of serotonin and melatonin, which improve the induction and quality of sleep...
October 19, 2023: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/37919614/metabolomics-mediated-elucidation-of-rice-responses-to-salt-stress
#26
REVIEW
Nitasana Rajkumari, Soni Chowrasia, Jyoti Nishad, Showkat Ahmad Ganie, Tapan Kumar Mondal
Role of salinity responsive metabolites of rice and its wild species has been discussed. Salinity stress is one of the important environmental stresses that severely affects rice productivity. Although, several vital physio-biochemical and molecular responses have been activated in rice under salinity stress which were well described in literatures, the mechanistic role of salt stress and microbes-induced metabolites to overcome salt stress in rice are less studied. Nevertheless, over the years, metabolomic studies have allowed a comprehensive analyses of rice salt stress responses...
November 3, 2023: Planta
https://read.qxmd.com/read/37898179/microbiota-derived-tryptophan-metabolism-impacts-on-health-aging-and-disease
#27
JOURNAL ARTICLE
Sonu Kumar Gupta, Sagar Vyavahare, Ian L Duchesne Blanes, Ford Berger, Carlos Isales, Sadanand Fulzele
The intricate interplay between gut microbiota and the host is pivotal in maintaining homeostasis and health. Dietary tryptophan (TRP) metabolism initiates a cascade of essential endogenous metabolites, including kynurenine, kynurenic acid, serotonin, and melatonin, as well as microbiota-derived Trp metabolites like tryptamine, indole propionic acid (IPA), and other indole derivatives. Notably, tryptamine and IPA, among the indole metabolites, exert crucial roles in modulating immune, metabolic, and neuronal responses at both local and distant sites...
October 26, 2023: Experimental Gerontology
https://read.qxmd.com/read/37897979/determination-of-well-being-related-markers-in-nails-by-liquid-chromatography-tandem-mass-spectrometry
#28
JOURNAL ARTICLE
Alex Gomez-Gomez, Blanca Montero-San Martin, Noemí Haro, Oscar J Pozo
Well-being is a multifactorial positive state that is highly influenced by some endogenous molecules that control happiness and euphoric feelings. These molecules, e.g., neurotransmitters, hormones and their derivatives, play a crucial role in metabolism and may be referred to as "well-being-related markers". The deregulation of well-being-related markers can lead to organism malfunctions and life-threatening states. In this research, we aimed to evaluate the potential of nails for the chronic production of several well-being-related markers...
October 26, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37896101/hormonal-interplay-leading-to-black-knot-disease-establishment-and-progression-in-plums
#29
JOURNAL ARTICLE
Ranjeet Shinde, Murali-Mohan Ayyanath, Mukund Shukla, Walid El Kayal, Praveen Saxena, Jayasankar Subramanian
Black Knot (BK) is a deadly disease of European ( Prunus domestics ) and Japanese ( Prunus salicina ) plums caused by the hemibiotrophic fungus Apiosporina morbosa . After infection, the appearance of warty black knots indicates a phytohormonal imbalance in infected tissues. Based on this hypothesis, we quantified phytohormones such as indole-3-acetic acid, tryptophan, indoleamines (N-acetylserotonin, serotonin, and melatonin), and cytokinins (zeatin, 6-benzyladenine, and 2-isopentenyladenine) in temporally collected tissues of susceptible and resistant genotypes belonging to European and Japanese plums during of BK progression...
October 21, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37887129/ruthenium-anchored-carbon-sphere-customized-sensor-for-the-selective-amperometric-detection-of-melatonin
#30
JOURNAL ARTICLE
Sivaguru Jayaraman, Thenmozhi Rajarathinam, Hyeon-Geun Jang, Dinakaran Thirumalai, Jaewon Lee, Hyun-Jong Paik, Seung-Cheol Chang
Melatonin (MT), a pineal gland hormone, regulates the sleep/wake cycle and is a potential biomarker for neurodegenerative disorders, depression, hypertension, and several cancers, including prostate cancer and hepatocarcinoma. The amperometric detection of MT was achieved using a sensor customized with ruthenium-incorporated carbon spheres (Ru-CS), possessing C- and O-rich catalytically active Ru surfaces. The non-covalent interactions and ion-molecule adducts between Ru and CS favor the formation of heterojunctions at the sensor-analyte interface, thus accelerating the reactions towards MT...
October 18, 2023: Biosensors
https://read.qxmd.com/read/37885113/circadian-rhythms-and-sleep-disorders-associated-to-major-depressive-disorder-pathophysiology-and-therapeutic-opportunities
#31
JOURNAL ARTICLE
Luana M Manosso, Luciano A Duarte, Nicoly S Martinello, Gisiane B Mathia, Gislaine Z Réus
Major depressive disorder (MDD) is a complex mood disorder. While much progress has been made in understanding the pathophysiology of MDD, no single mechanism can explain all facets of this disorder. Several studies show that disturbances in biological rhythms can lead to the development of MDD. Indeed, insomnia or hypersomnia are symptoms included in the MDD diagnostic criteria. Clinical studies and meta-analyses showed a strong relationship between MDD and sleep disorders. Sleep disorder and MDD are associated with activation in the hypothalamicpituitary-adrenal (HPA) axis and inflammation...
October 25, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37884227/multi-effective-components-and-their-target-mechanism-of-ziziphi-spinosae-semen-in-the-treatment-of-insomnia
#32
JOURNAL ARTICLE
Xinwei Zhao, Tao Hou, Han Zhou, Ziling Liu, Yanfang Liu, Chaoran Wang, Zhimou Guo, Dongping Yu, Qing Xu, Jixia Wang, Xinmiao Liang
Insomnia is a common and refractory disease. Since more than 2000 years ago, people have been using Ziziphi Spinosae Semen (ZSS). However, there are lack of molecular mechanisms of sleep promotion effects of ZSS. The purpose of this study is to clarify the active ingredients in ZSS that are used to treat insomnia. Using a method called cellular label-free integrative pharmacology (CLIP), we established five insomnia-related target models, including serotonin (5HT2A and 5HT1A ), melatonin (MT1 ), dopamine (D2 ) and epinephrine (β2 ) receptors...
October 24, 2023: Fitoterapia
https://read.qxmd.com/read/37807406/gut-microbiome-and-circadian-interactions-with-platelets-across-human-diseases-including-alzheimer-s-disease-amyotrophic-lateral-sclerosis-and-cancer
#33
JOURNAL ARTICLE
George Anderson
Platelets have traditionally been investigated for their role in clot formation in the course of cardiovascular diseases and strokes. However, recent work indicates platelets to be an integral aspect of wider systemic processes, with relevance to the pathophysiology of a host of diverse medical conditions, including neurodegenerative disorders and cancer. This article reviews platelet function and interactions with the gut microbiome and circadian systems, highlighting the role of the platelet mitochondrial melatonergic pathway in determining platelet activation, fluxes and plasticity...
October 2, 2023: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/37789226/polymorphisms-in-genes-of-melatonin-biosynthesis-and-signaling-support-the-light-at-night-hypothesis-for-breast-cancer
#34
JOURNAL ARTICLE
Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Robert Herold, Claudia Terschüren, Wing-Yee Lo, Pascal Guénel, Thérèse Truong, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Irene L Andrulis, Hermann Brenner, Jenny Chang-Claude, Angela Cox, Simon S Cross, Kamila Czene, Mikael Eriksson, Jonine D Figueroa, Montserrat García-Closas, Mark S Goldberg, Ute Hamann, Wei He, Bernd Holleczek, John L Hopper, Anna Jakubowska, Yon-Dschun Ko, Jan Lubiński, Anna Marie Mulligan, Nadia Obi, Valerie Rhenius, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C Southey, Wei Zheng, Alison M Dunning, Paul D P Pharoah, Per Hall, Douglas F Easton, Thomas Brüning, Hiltrud Brauch, Volker Harth, Sylvia Rabstein
Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls)...
October 3, 2023: European Journal of Epidemiology
https://read.qxmd.com/read/37737915/investigation-of-the-effect-of-ramadan-fasting-on-serum-levels-of-melatonin-cortisol-and-serotonin-the-case-of-turkey
#35
JOURNAL ARTICLE
Esra Şentürk, Metin Yıldız, Murat Şentürk, Ela Varol, Mehmet Salih Yildirim, Dursun Alper Yilmaz, Mehmet Emin Atay
INTRODUCTION: The aim of this study is to examine the effects of Ramadan fasting on melatonin, cortisol, and serotonin levels. METHODS: In this study, the blood of 19 healthy male individuals between the ages of 26 and 51, registered in Agri (Turkey) Family Health Center and fasting during Ramadan, was studied. The study was carried out in 2021-2022. The SPSS-22 package program was used in the analysis of the data. Wilcoxon analysis was used in the study. RESULTS: It was determined that the pre-test-post-test melatonin and cortisol levels of the individuals were not statistically significant (p>0...
September 22, 2023: Irish Journal of Medical Science
https://read.qxmd.com/read/37735631/agomelatine-augmentation-of-sertraline-in-the-treatment-of-moderate-to-severe-obsessive-compulsive-disorder-a-randomized-double-blinded-placebo-controlled-clinical-trial
#36
JOURNAL ARTICLE
Marjan Shokrani, Sanaz Askari, Negin Eissazade, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
BACKGROUND: As 40-60% of the patients with obsessive-compulsive disorder (OCD) do not adequately respond to the first-line treatment, finding an effective second-line treatment is required. Our aim was to assess the efficacy and safety of agomelatine (a selective melatonin receptor agonist and a 5-hydroxytryptamine (HT)2 C antagonist) augmentation of sertraline in the treatment of patients with moderate to severe OCD. METHODS: In this 12-week randomized, double-blinded, placebo-controlled, parallel-group clinical trial, 65 patients with moderate to severe OCD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth edition (DSM-5) criteria and a Yale-Brown obsessive compulsive scale (Y-BOCS) score of over 21, were included...
September 21, 2023: BMC Psychiatry
https://read.qxmd.com/read/37731057/standardized-ileal-digestible-tryptophan-and-lysine-affects-the-eating-and-sleeping-behavior-of-15-30-kg-barrows
#37
JOURNAL ARTICLE
Vinicius Ricardo Cambito de Paula, Tiago Junior Pasquetti, Newton Tavares Escocard de Oliveira, Wesley Tanamati, Robson Mateus Freitas Silveira, Paulo Cesar Pozza
The objective of this study was to evaluate the effect of standardized ileal digestible (SID) tryptophan (Trp) and lysine (Lys) levels on eating and sleeping behavior and the respective feed intake of barrows. Sixty-four pigs, averaging 15.00 ± 1.63 kg of initial body weight, were used and distributed in a randomized blocks design, in a 4 × 4 factorial scheme, consisting of four levels of SID Trp (0.155, 0.185, 0.215, 0.245%) and four levels of SID Lys (0.972, 1.112, 1.252, and 1.392%). Behavior evaluation was performed by an instantaneous sampling using 10-min intervals during 24 h, at each 7 days (days 7, 14, and 21), and each day was divided into four times of 6 h each one (08:30-14:20, 14:30-20:20, 20:30-02:20, and 02:30-08:20 h), during all the experimental period, yielding a total of 3 × 24 h behavior recordings (72 h) × 6 10-min intervals, totalizing 432 observations per animal...
September 21, 2023: Tropical Animal Health and Production
https://read.qxmd.com/read/37722934/monoamines-role-in-islet-cell-function-and-type-2-diabetes-risk
#38
REVIEW
Fiona Louise Roberts, Luis Rodrigo Cataldo, Malin Fex
The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro...
September 16, 2023: Trends in Molecular Medicine
https://read.qxmd.com/read/37684283/understanding-the-mechanism-of-red-light-induced-melatonin-biosynthesis-facilitates-the-engineering-of-melatonin-enriched-tomatoes
#39
JOURNAL ARTICLE
Zixin Zhang, Xin Zhang, Yuting Chen, Wenqian Jiang, Jing Zhang, Jiayu Wang, Yanjun Wu, Shouchuang Wang, Xiao Yang, Mingchun Liu, Yang Zhang
Melatonin is a functionally conserved broad-spectrum physiological regulator found in most biological organisms in nature. Enrichment of tomato fruit with melatonin not only enhances its agronomic traits but also provides extra health benefits. In this study, we elucidate the full melatonin biosynthesis pathway in tomato fruit by identifying biosynthesis-related genes that encode caffeic acid O-methyltransferase 2 (SlCOMT2) and N-acetyl-5-hydroxytryptamine-methyltransferases 5/7 (SlASMT5/7). We further reveal that red light supplementation significantly enhances the melatonin content in tomato fruit...
September 8, 2023: Nature Communications
https://read.qxmd.com/read/37664841/the-role-of-neurochemicals-stress-hormones-and-immune-system-in-the-positive-feedback-loops-between-diabetes-obesity-and-depression
#40
REVIEW
Julian B Wilson, Ma'ayan Epstein, Briana Lopez, Amira K Brown, Kabirullah Lutfy, Theodore C Friedman
Type 2 diabetes mellitus (T2DM) and depression are significant public health and socioeconomic issues. They commonly co-occur, with T2DM occurring in 11.3% of the US population, while depression has a prevalence of about 9%, with higher rates among youths. Approximately 31% of patients with T2DM suffer from depressive symptoms, with 11.4% having major depressive disorders, which is twice as high as the prevalence of depression in patients without T2DM. Additionally, over 80% of people with T2DM are overweight or obese...
2023: Frontiers in Endocrinology
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