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https://www.readbyqxmd.com/read/27875954/how-immune-inflammatory-processes-link-cns-and-psychiatric-disorders-classification-and-treatment-implications
#1
George Anderson, Michael Maes
In this article the emerging biological overlaps of CNS disorders and psychiatric conditions are reviewed. Recent work has highlighted how immune-inflammatory processes and their interactions with oxidative and nitrosative stress, couple to drive changes in neuroregulatory tryptophan catabolites, with consequences for serotonin availability, including as a precursor for the melatonergic pathways. Subsequent alterations in the regulation of local melatonin synthesis are likely to have direct impacts on the reactivity of immune cells, both centrally and systemically...
November 22, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27865517/effects-of-melatonin-in-the-treatment-of-asthenia-in-aneurysmal-subarachnoid-hemorrhage
#2
V Gilard, F-X Ferracci, O Langlois, S Derrey, F Proust, S Curey
BACKGROUND AND OBJECTIVES: Survivors of aneurysmal subarachnoid hemorrhage (aSAH) commonly experience sleep disorders resulting in asthenia. The objective of this prospective study was to determine, in a cohort of patients with treated ruptured intracranial aneurysm (IA), the proportion of asthenia at 2months, in a cohort of patients treated with melatonin and in a control cohort. PATIENTS AND METHODS: Twenty consecutive patients admitted for the treatment of ruptured IA and able to answer a standardized questionnaire were included in the study...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27858294/sleep-quality-morningness-eveningness-preference-mood-profile-and-levels-of-serum-melatonin-in-migraine-patients-a-case-control-study
#3
Hasan Hüseyin Kozak, Murat Boysan, Ali Ulvi Uca, Adem Aydın, İbrahim Kılınç, Emine Genç, Mustafa Altaş, Dilara Cari Güngör, Keziban Turgut, Nejla Özer
The melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated that migraine attacks have a seasonal, menstrual, and circadian timing, suggesting that chronobiological mechanisms and their alterations may causally involve in the etiology of the disease. However, the topic has received relatively little attention in the migraine literature...
November 17, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27829983/melatoninergic-system-in-parkinson-s-disease-from-neuroprotection-to-the-management-of-motor-and-nonmotor-symptoms
#4
REVIEW
Josiel Mileno Mack, Marissa Giovanna Schamne, Tuane Bazanella Sampaio, Renata Aparecida Nedel Pértile, Pedro Augusto Carlos Magno Fernandes, Regina P Markus, Rui Daniel Prediger
Melatonin is synthesized by several tissues besides the pineal gland, and beyond its regulatory effects in light-dark cycle, melatonin is a hormone with neuroprotective, anti-inflammatory, and antioxidant properties. Melatonin acts as a free-radical scavenger, reducing reactive species and improving mitochondrial homeostasis. Melatonin also regulates the expression of neurotrophins that are involved in the survival of dopaminergic neurons and reduces α-synuclein aggregation, thus protecting the dopaminergic system against damage...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27821114/bright-light-therapy-in-pregnant-women-with-major-depressive-disorder-study-protocol-for-a-randomized-double-blind-controlled-clinical-trial
#5
Babette Bais, Astrid M Kamperman, Marjolein D van der Zwaag, Gwen C Dieleman, Hanneke W Harmsen van der Vliet-Torij, Hilmar H Bijma, Ritsaert Lieverse, Witte J G Hoogendijk, Mijke P Lambregtse-van den Berg
BACKGROUND: Depression during pregnancy is a common and high impact disease. Generally, 5-10 % of pregnant women suffer from depression. Children who have been exposed to maternal depression during pregnancy have a higher risk of adverse birth outcomes and more often show cognitive, emotional and behavioural problems. Therefore, early detection and treatment of antepartum depression is necessary. Both psychotherapy and antidepressant medication, first choice treatments in a non-pregnant population, have limitations in treating depression during pregnancy...
November 8, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27812851/pineal-volume-and-evening-melatonin-in-young-people-with-affective-disorders
#6
Joanne S Carpenter, Amy C Abelmann, Sean N Hatton, Rébecca Robillard, Daniel F Hermens, Maxwell R Bennett, Jim Lagopoulos, Ian B Hickie
Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin. Previous research reports relationships between pineal gland volumes, melatonin secretion, and sleep-wake cycles, but the relationship between these factors has not been explored in affective disorders. This study aimed to characterize these factors and explore associations with mood symptoms and functioning in a sample of young people with affective disorders...
November 3, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27797990/cohort-profile-the-baependi-heart-study-a-family-based-highly-admixed-cohort-study-in-a-rural-brazilian-town
#7
Kieren J Egan, Malcolm von Schantz, André B Negrão, Hadassa C Santos, Andréa R V R Horimoto, Nubia E Duarte, Guilherme C Gonçalves, Júlia M P Soler, Mariza de Andrade, Geraldo Lorenzi-Filho, Homero Vallada, Tâmara P Taporoski, Mario Pedrazzoli, Ana P Azambuja, Camila M de Oliveira, Rafael O Alvim, José E Krieger, Alexandre C Pereira
PURPOSE: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits...
October 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27792133/effects-of-walnut-consumption-on-mood-in-young-adults-a-randomized-controlled-trial
#8
Peter Pribis
Walnuts contain a number of potentially neuroprotective compounds like vitamin E, folate, melatonin, several antioxidative polyphenols and significant amounts of ω-3 fatty acids. The present study sought to determine the effect of walnuts on mood in healthy volunteers. Sixty-four college students were randomly assigned to two treatment sequences in a crossover fashion: walnut-placebo or placebo-walnut. At baseline mood was assessed using Profiles of Mood States (POMS). Data was collected again after eight weeks of intervention...
October 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27769202/a-double-blind-randomized-controlled-trial-to-assess-the-effect-of-bright-light-therapy-on-depression-in-patients-with-parkinson-s-disease
#9
Sonja Rutten, Chris Vriend, Jan H Smit, Henk W Berendse, Adriaan W Hoogendoorn, Odile A van den Heuvel, Ysbrand D van der Werf
BACKGROUND: A disturbed circadian rhythm seems to be a causal factor in the occurrence of depressive disorders in patients with Parkinson's disease (PD). The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT) might be a new treatment option for depression in PD patients. METHODS/DESIGN: In this double-blind controlled trial, 84 subjects with idiopathic PD are randomized to either BLT or a control light condition. The BLT condition emits white light with an intensity of 10,000 Lux, while the control device emits dim white light of 200 Lux, which is presumed to be too low to influence the circadian rhythm...
October 21, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27756833/the-frontal-cortex-as-a-network-hub-controlling-mood-and-cognition-probing-its-neurochemical-substrates-for-improved-therapy-of-psychiatric-and-neurological-disorders
#10
Mark J Millan, Jean-Michel Rivet, Alain Gobert
The highly-interconnected and neurochemically-rich frontal cortex plays a crucial role in the regulation of mood and cognition, domains disrupted in depression and other central nervous system disorders, and it is an important site of action for their therapeutic control. For improving our understanding of the function and dysfunction of the frontal cortex, and for identifying improved treatments, quantification of extracellular pools of neuromodulators by microdialysis in freely-moving rodents has proven indispensable...
October 17, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27751669/review-of-safety-and-efficacy-of-sleep-medicines-in-older-adults
#11
REVIEW
Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
November 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27712107/light-therapy-with-scheduled-rise-times-in-young-adults-with-delayed-sleep-phase-disorder-therapeutic-outcomes-and-possible-predictors
#12
Katarina Danielsson, Markus Jansson-Fröjmark, Jan-Erik Broman, Agneta Markström
Clinical trials with light therapy (LT) for delayed sleep phase disorder (DSPD) are sparse and little is known about factors that are favorable for improvements. In this study, LT with scheduled rise times was conducted at home for 14 days by 44 participants with DSPD aged 16-26 years. Primary outcomes were sleep onset and sleep offset. Potential predictors were demographic characteristics, chronotype, dim light melatonin onset, the number of days the LT lamp was used, the daily duration of LT, daytime sleepiness, anxiety, depression, worry, and rumination...
August 11, 2016: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/27692050/prevalence-of-circadian-misalignment-and-its-association-with-depressive-symptoms-in-delayed-sleep-phase-disorder
#13
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha M W Rajaratnam
STUDY OBJECTIVE: To examine the prevalence of circadian misalignment in clinically diagnosed DSPD, and compare mood and daytime functioning in those with and without a circadian basis for the disorder. METHODS: 182 DSPD patients aged 16 to 64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO). Based on the DLMO assessments, patients were classified into two groups: circadian DSPD, defined as DLMO occurring at or after desired bedtime, or non-circadian DSPD, defined as DLMO occurring before desired bedtime...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27663044/-metabolic-syndrome-and-bipolar-disorder-is-sleep-the-missing-link
#14
H Brochard, C Boudebesse, C Henry, O Godin, M Leboyer, B Étain
OBJECTIVE: To examine the pathophysiologic mechanisms that may link circadian disorder and metabolic syndrome in bipolar disorder (BP). METHOD: A systematic review of the literature was conducted from January 2013 to January 2015, using the Medline and Cochrane databases, using the keywords "metabolic syndrome", "obesity", "leptin" and "circadian disorders", "sleeping disorders" and cross-referencing them with "bipolar disorder". The following types of publications were candidates for review: (i) clinical trials; (ii) studies involving patients diagnosed with bipolar disorder; (iii) studies involving patients with sleeping disorder; or (iv) data about metabolic syndrome...
September 20, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27661417/sleep-and-circadian-alterations-in-people-at-risk-for-bipolar-disorder-a-systematic-review
#15
Matias Carvalho Aguiar Melo, Raquel Fernandes Garcia, Vicente Bezerra Linhares Neto, Mariana Brasil Sá, Licia Marah Figueredo de Mesquita, Carolina Freitas Cardeal de Araújo, Veralice Meireles Sales de Bruin
BACKGROUND: Sleep and circadian abnormalities have been mostly demonstrated in bipolar patients. However, it is not clear whether these alterations are present in population at high risk for bipolar disorder (BD), indicating a possible risk factor for this condition. OBJECTIVE: This systematic review aims to define current evidence about sleep and rhythm alterations in people at risk for BD and to evaluate sleep and circadian disorders as risk factor for BD. METHODS: The systematic review included all articles about the topic until February 2016...
September 13, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27634184/multiple-sclerosis-gut-microbiota-and-permeability-role-of-tryptophan-catabolites-depression-and-the-driving-down-of-local-melatonin
#16
Moses Rodriguez, Bharath Wootla, George Anderson
BACKGROUND: Alterations in gut microbiota, coupled to increased gut permeability are now widely recognized as having a role in the etiology, course and treatment of many medical conditions, including autoimmune and neurodegenerative disorders. METHODS: In this review, the role that such gut changes play over the course of multiple sclerosis (MS) is detailed. RESULTS: Given the wide array of biological factors and processes that have been shown to be altered in MS, including changes in the gut, this allows for a better integration of the diverse array of pathophysiological processes linked to MS...
September 15, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27604608/gut-permeability-and-microbiota-in-parkinson-s-disease-role-of-depression-tryptophan-catabolites-oxidative-and-nitrosative-stress-and-melatoninergic-pathways
#17
George Anderson, M Seo, M Berk, A F Carvalho, M Maes
BACKGROUND: Increased gut permeability (leaky gut) and alterations in gut microbiota are now widely accepted as relevant to the etiology, course and treatment of many neuropsychiatric disorders, including Parkinson disease (PD). Although a wide array of data on the biological underpinnings of PD has not yet been linked to such gut-associated changes, increased gut permeability and dysregulated microbiota alter many pathways germane to PD. METHODS: In this article we review and integrate these wider biological changes in PD, including increased oxidative and nitrosative stress, immune-inflammatory processes, tryptophan catabolites and alterations in serotoninergic and melatoninergic pathways...
September 6, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27536769/major-depression-and-psoriasis-a-psychodermatological-phenomenon
#18
Hassaan Tohid, Daniyal Aleem, Chantal Jackson
OBJECTIVE: The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis. METHOD: A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant. RESULTS: A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8...
2016: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/27524206/chronotype-and-circadian-rhythm-in-bipolar-disorder-a-systematic-review
#19
Matias C A Melo, Rafael L C Abreu, Vicente B Linhares Neto, Pedro F C de Bruin, Veralice M S de Bruin
Despite a complex relationship between mood, sleep and rhythm, the impact of circadian disruptions on bipolar disorder (BD) has not been clarified. The purpose of this systematic review was to define current evidence regarding chronotype and circadian rhythm patterns in BD patients. 42 studies were included, involving 3432 BD patients. Disruption of the biological rhythm was identified, even in drug-naïve BD patients and independently of mood status. Daily profiles of melatonin levels and cortisol indicated a delayed phase...
July 1, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27504868/agomelatine-and-transient-elevation-of-creatine-phosphokinase
#20
A Zormann, J Blum, C Suenderhauf, M Vogel, A Walter
Agomelatine is an antidepressant drug with moderate agonistic action at the melatonine receptor MT1 and weak effect at MT2. According to clinical studies, agomelatine ameliorates depressive symptoms and improves sleep quality. Side effects such as elevated liver enzymes are well-known. Therefore, routine laboratory monitoring of liver function is recommended periodically throughout treatment because of a rare risk of more serious liver reactions. 2 patients with creatine phosphokinase elevation during treatment with agomelatine are presented...
August 9, 2016: Drug Research
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