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Pneumoconiosis

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https://www.readbyqxmd.com/read/29926557/clinical-characteristics-of-false-positive-lymph-node-on-chest-ct-or-pet-ct-confirmed-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-lung-cancer
#1
Jongmin Lee, Young Kyoon Kim, Ye Young Seo, Eun Kyoung Choi, Dong Soo Lee, Yeon Sil Kim, Sook Hee Hong, Jin Hyoung Kang, Kyo Young Lee, Jae Kil Park, Sook Whan Sung, Hyun Bin Kim, Mi Sun Park, Hyeon Woo Yim, Seung Joon Kim
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure to evaluate suspicious lymph node involvement of lung cancer because computed tomography (CT) and ¹⁸F-fluorodeoxyglucose positron emission tomography-CT (PET-CT) have limitations in their sensitivity and specificity. There are a number of benign causes of false positive lymph node such as anthracosis or anthracofibrosis, pneumoconiosis, old or active tuberculosis, interstitial lung disease, and other infectious conditions including pneumonia...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29879078/treatment-rationale-and-design-of-the-spiral-study-a-phase-ii-trial-of-osimertinib-in-elderly-epidermal-growth-factor-receptor-t790m-positive-nonsmall-cell-lung-cancer-patients-who-progressed-during-prior-egfr-tki-treatment
#2
Junji Uchino, Akira Nakao, Nobuyo Tamiya, Yoshiko Kaneko, Tadaaki Yamada, Kenichi Yoshimura, Masaki Fujita, Koichi Takayama
BACKGROUND: Advances in epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment led to research on the mechanism of the resistance have revealed that an occurrence of T790M gene mutation generated in exon 20 of the EGFR gene is associated with approximately 50% to 60% of observed resistance. Osimertinib, a 3rd-generation EGFR-TKI, has been shown to be effective against both EGFR tyrosine kinase inhibitor-sensitizing and T790M resistance mutations. In this study, we prospectively investigate the efficacy and safety of osimertinib in elderly patients aged ≥75 years, with ineffective prior EGFR-TKI treatment or with recurrence of EGFR-TKI mutation-positive or T790M mutation-positive nonsmall-cell lung cancer...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29872441/type-2-immune-mechanisms-in-carbon-nanotube-induced-lung-fibrosis
#3
REVIEW
Jie Dong, Qiang Ma
T helper (Th) 2-dependent type 2 immune pathways have been recognized as an important driver for the development of fibrosis. Upon stimulation, activated Th2 immune cells and type 2 cytokines interact with inflammatory and tissue repair functions to stimulate an overzealous reparative response to tissue damage, leading to organ fibrosis and destruction. In this connection, type 2 pathways are activated by a variety of insults and pathological conditions to modulate the response. Carbon nanotubes (CNTs) are nanomaterials with a wide range of applications...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29806618/assessment-of-physicians-proficiency-in-reading-chest-radiographs-for-pneumoconiosis-based-on-a-60-film-examination-set-with-two-factors-constituting-eight-indices
#4
Taro Tamura, Yukinori Kusaka, Narufumi Suganuma, Kazuhiro Suzuki, Ponglada Subhannachart, Somkiat Siriruttanapruk, Narongpon Dumavibhat, Xing Zhang, P K Sishodiya, Tran Anh Thanh, Kurt G Hering, John E Parker, Eduardo Algranti, Francisco Santos-O'Connor, Hisao Shida, Masanori Akira
Two hundred and thirty-three individuals read chest x-ray images (CXR) in the Asian Intensive Reader of Pneumoconiosis (AIR Pneumo) workshop. Their proficiency in reading CXR for pneumoconiosis was calculated using eight indices (X1-X8), as follows: sensitivity (X1) and specificity (X2) for pneumoconiosis; sensitivity (X3) and specificity (X4) for large opacities; sensitivity (X5) and specificity (X6) for pleural plaques; profusion increment consistency (X7); and consistency for shape differentiation (X8). For these eight indices, one-way analysis of variance (ANOVA) and Scheffe's multiple comparison were conducted on six groups, based on the participants' specialty: radiology, respiratory medicine, industrial medicine, public health, general internal medicine, and miscellaneous physicians...
May 26, 2018: Industrial Health
https://www.readbyqxmd.com/read/29788999/the-first-case-of-multiple-pulmonary-granulomas-with-amyloid-deposition-in-a-dental-technician-a-rare-manifestation-as-an-occupational-lung-disease
#5
Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura, Masakazu Ichinose
BACKGROUND: Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and can be classified into primary (idiopathic) and secondary (associated with various inflammatory diseases, hereditary, or neoplastic). To date, the development of pulmonary amyloidosis in dental workers has not been reported. CASE PRESENTATION: A 58-year-old Japanese female presented with chest discomfort and low-grade fever that has persisted for 2 months...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29774711/-health-impact-of-asbestos-fibres-naturally-occurring-in-mount-pollino-area-basilicata-region-southern-italy
#6
Angelo Caputo, Marco De Santis, Valerio Manno, Gabriella Cauzillo, Biagio Maria Bruni, Lorenzo Palumbo, Susanna Conti, Pietro Comba
OBJECTIVES: to estimate the health impact of asbestos fibres naturally occurring in Mount Pollino area (Basilicata Region, Southern Italy). DESIGN: geographic mortality, hospitalization, and incidence study. Setting and participant s: population resident in 12 Municipalities of Mount Pollino area with naturally occurring asbestos fibres. MAIN OUTCOME MEASURES: standardized mortality ratio (SMR) and standardized hospitalization rate (SHR) for asbestos-related diseases; standardized incidence ratio (SIR) for mesotheliomas...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29772681/global-asbestos-disaster
#7
Sugio Furuya, Odgerel Chimed-Ochir, Ken Takahashi, Annette David, Jukka Takala
Introduction : Asbestos has been used for thousands of years but only at a large industrial scale for about 100⁻150 years. The first identified disease was asbestosis, a type of incurable pneumoconiosis caused by asbestos dust and fibres. The latest estimate of global number of asbestosis deaths from the Global Burden of Disease estimate 2016 is 3495. Asbestos-caused cancer was identified in the late 1930's but despite today's overwhelming evidence of the strong carcinogenicity of all asbestos types, including chrysotile, it is still widely used globally...
May 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29743783/dental-technicians-pneumoconiosis-illness-behind-a-healthy-smile-case-series-of-a-reference-center-in-turkey
#8
Nur Şafak Alici, Ayşe Coşkun Beyan, Yücel Demıral, Arif Çimrin
Background: Dental laboratories include many hazards and risks. Dental technicians working in an unfavorable work environment in Turkey and other parts of the world may develop pneumoconiosis as a result of exposure to dust, depending on exposure time. In this study, we aimed to investigate the clinical and laboratory findings of dental technicians. Materials and Methods: The study consists of a case series. Between 2013 and 2016, a total of 70 who were working as a dental technician and referred to our clinic with suspicion of occupational disease were evaluated...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29743082/combined-effect-of-silica-dust-exposure-and-cigarette-smoking-on-total-and-cause-specific-mortality-in-iron-miners-a-cohort-study
#9
Hanpeng Lai, Yuewei Liu, Min Zhou, Tingming Shi, Yun Zhou, Shaofan Weng, Weihong Chen
BACKGROUND: Both cigarette smoking and long-term exposure to crystalline silica dust were reported to be associated with increased mortality. However, the combined effect of both factors has not been well evaluated. METHODS: We investigated a retro-prospective cohort of 7,665 workers from one Chinese iron mine with a median follow-up of 42.8 years. Cumulative silica exposure was estimated for each worker by linking work histories with a job-exposure matrix. Cigarette smoking information was collected through face-to-face questionnaires...
May 9, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29732582/continued-increase-in-lung-transplantation-for-coal-workers-pneumoconiosis-in-the-united-states
#10
David J Blackley, Cara N Halldin, A Scott Laney
BACKGROUND: Severe coal workers' pneumoconiosis (CWP) is increasingly common, and sometimes requires lung transplantation. METHODS: Using Organ Procurement and Transplantation Network data, we updated the trend for CWP-related lung transplants, described CWP patients who have been waitlisted but not transplanted, and characterized the primary payer of medical costs for CWP-related and other occupational lung disease transplants. RESULTS: There have been at least 62 CWP-related lung transplants; 49 (79%) occurred in the last decade...
May 6, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29709849/sources-behaviour-and-environmental-and-human-health-risks-of-high-technology-rare-earth-elements-as-emerging-contaminants
#11
REVIEW
Willis Gwenzi, Lynda Mangori, Concilia Danha, Nhamo Chaukura, Nothando Dunjana, Edmond Sanganyado
Recent studies show that high-technology rare earth elements (REEs) of anthropogenic origin occur in the environment including in aquatic systems, suggesting REEs are contaminants of emerging concern. However, compared to organic contaminants, there is a lack of comprehensive reviews on the anthropogenic sources, environmental behaviour, and public and ecological health risks of REEs. The current review aims to: (1) identify anthropogenic sources, transfer mechanisms, and environmental behaviour of REEs; (2) highlight the human and ecological health risks of REEs and propose mitigation measures; and (3) identify knowledge gaps and future research directions...
September 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29704724/both-sided-native-valve-infective-endocarditis-in-a-drug-addict-with-incidental-pneumoconiosis
#12
Shashank Tyagi, Swati Patki, Pradeep Vaideeswar, Vikas Meshram
Involvement of both right and left heart chambers with infective endocarditis is extremely rare. In this case report, we aimed to present a rare case of Infective endocarditis (IE) in an intravenous & inhalational drug misuse involving both cardiac chambers with incidental pneumoconiosis.
April 23, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29642880/prevalence-of-latent-tuberculosis-infection-among-coal-workers-pneumoconiosis-patients-in-china-a-cross-sectional-study
#13
Yan Jin, Huanqiang Wang, Jianfang Zhang, Chunguang Ding, Ke Wen, Jingguang Fan, Tao Li
BACKGROUND: Little is known about the prevalence of latent tuberculosis infection (LTBI) among coal workers' pneumoconiosis (CWP) patients. To estimate the prevalence of LTBI and identify its associated risk factors among CWP patients. METHODS: A cross-sectional study was conducted to assess the prevalence of LTBI. Participants were screened for active TB or a history of TB by X-ray and those that underwent QuantiFERON-TB Gold In-Tube (QFT) test. A standardized questionnaire was completed and risk factors were assessed for acquiring TB...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29563194/establishment-and-application-of-an-index-system-for-prevention-of-coal-workers-pneumoconiosis-a-delphi-and-analytic-hierarchy-process-study-in-four-state-owned-coal-enterprises-of-china
#14
Kai Cui, Fuhai Shen, Bing Han, Hongbo Liu, Jie Chen
OBJECTIVE: To explore the difference of cumulative incidence rate of coal workers' pneumoconiosis (CWP) among four large state-owned coal enterprises in northern China, we created an index system for evaluating the quality of comprehensive measures against CWP and applied the system to evaluate and compare the measures of the four coal enterprises. METHODS: A two-round Delphi investigation was conducted to identify the indicators in the index system. The weight values of the indicators were calculated with analytic hierarchy process methods...
March 21, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29548652/clinical-features-of-secondary-spontaneous-pneumothorax-complicated-with-silicosis
#15
Norichika Iga, Hideyuki Nishi, Nobukazu Fujimoto, Takumi Kishimoto
BACKGROUND: Few studies have focused on the management of secondary spontaneous pneumothorax (SSP) as a complication of pneumoconiosis. The aim of this study was to investigate the clinical features and therapeutic course of SSP associated with silicosis. METHODS: Between April 2005 and March 2015, 17 patients with silicosis underwent chest tube drainage for SSP in our institution. We retrospectively analyzed patient characteristics, type of treatment, clinical course, rate of recurrence, and survival time, and compared them with those of 30 patients diagnosed with chronic obstructive pulmonary disease (COPD) during the same period...
March 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29516679/exosomal-mirna-profiling-to-identify-nanoparticle-phagocytic-mechanisms
#16
Lin Zhang, Changfu Hao, Sanqiao Yao, Rong Tang, Wei Guo, Hongbin Cong, Jiangfeng Li, Lei Bao, Di Wang, Yiping Li, Xinghao Yu, Shuyin Duan, Wu Yao
Inhaling a dangerous amount of nanoparticles leads to pulmonary inflammatory and immune disorders, which integrates several kinds of cells. Exosomes are suggested to play a crucial role in intercellular communication via miRNA transmission. To investigate the role of exosomal miRNA in nanoparticle phagocytosis, a total of 54 pneumoconiosis patients along with 100 healthy controls are recruited, exosomes derived from their venous blood are collected, and then exosomal miRNAs are profiled with high-throughput sequencing technology...
April 2018: Small
https://www.readbyqxmd.com/read/29495186/-diagnosis-of-occupational-pneumoconiosis-in-the-absence-of-one-side-lung-tissue
#17
J N Zheng, K Ma, Y Xia
No abstract text is available yet for this article.
January 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29495157/-incidence-of-occupational-diseases-in-a-province-of-china-during-the-period-of-twelfth-five-year-plan-and-its-trend
#18
Q Q Gao, H D Zhang, Y Bai, L Han, H Shen, J Zhang, B L Zhu
Objective: To investigate the incidence of occupational diseases in a province of China during the period of "Twelfth Five-Year Plan" , and to analyze the features of disease spectrum, the characteristics of regional and industrial distribution, and incidence trend. Methods: Data (2011-2015) were collected from the Information System of Occupational Diseases and Occupational Health to analyze the reported cases of occupational diseases during the period of "Twelfth Five-Year Plan". A statistical analysis was performed to identify the characteristics of the disease distribution in terms of sex, age, working years, enterprise type, enterprise scale, and region, as well as the incidence trend...
December 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29487788/should-hut-lung-be-called-domestically-acquired-particulate-lung-disease-or-domestically-acquired-pneumoconiosis
#19
Adel Asaad, Kimberley Cao, Mark Rumbak
Indoor air pollution appears to be a major environmental and public health hazard for large numbers of the underdeveloped world's population. A detailed environmental history is important for making diagnosis in most individuals from foreign rural settings with nonspecific respiratory symptoms. In this report, we describe an illustrative case of domestically acquired particulate lung disease (DAPLD) or "hut lung" in a 65-year-old Sudanese male who immigrated to the United States in 1986. He presented with symptoms of chronic productive cough and dyspnea...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29465110/james-craufurd-gregory-19th-century-scottish-physicians-and-the-link-between-occupation-as-a-coal-miner-and-lung-disease
#20
K Donaldson, W A Wallace, T A Elliot, C Henry
By the mid-19th century about 200,000 miners were employed in a UK coal mining industry still growing with the advances of the Industrial Revolution. Coal miners were long known to suffer poor health but the link to inhaling dust in the mines had not been made. In 1813 George Pearson was the first to suggest that darkening of lungs seen in normal individuals as they aged was caused by inhaled soot from burning oil, candles and coal, which were the common domestic sources of heat and light. In 1831 Dr James Craufurd Gregory first described black pigmentation and disease in the lungs of a deceased coal miner and linked this to pulmonary accumulation of coal mine dust...
September 2017: Journal of the Royal College of Physicians of Edinburgh
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