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Pneumoconiosis

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https://www.readbyqxmd.com/read/28806260/68ga-psma-ligand-pet-ct-uptake-in-anthracosilicosis
#1
Madeleine McGuiness, Brett Sounness
This interesting image illustrates a case of biopsy-proven pulmonary anthracosilicosis, a mixed dust pneumoconiosis, associated with Ga-PSMA-ligand uptake. Prostate-specific membrane antigen (PSMA) is an emerging imaging biomarker, with clinical application in evaluation of prostate cancer using Ga-PSMA-ligand PET/CT. Contrary to its name, PSMA is expressed in a number of other normal tissues and pathological states. Prostate-specific membrane antigen expression has been linked to tumor angiogenesis in various other epithelial neoplasms, as well as neovasculature associated with tissue regeneration and repair...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28801410/radiographic-features-of-importance-in-the-national-institute-for-occupational-safety-and-health-administered-coal-workers-health-surveillance-program-characterising-the-use-of-the-other-symbols
#2
Cara N Halldin, Janet M Hale, David J Blackley, A Scott Laney
OBJECTIVE: The National Institute for Occupation Safety and Health-administered Coal Workers' Health Surveillance Program (CWHSP) provides radiographic pneumoconiosis screening for US coal miners. Radiographs are classified by readers according to International Labour Office criteria. In addition to pneumoconiotic parenchymal and pleural lung abnormalities, readers document radiographic features of importance (other symbols). Other symbols are not meant to imply a diagnosis or interpretation but are relevant as they provide information beyond a pneumoconiosis classification for features related to dust exposure and other aetiologies...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28795953/diagnostic-accuracy-of-breath-tests-for-pneumoconiosis-using-an-electronic-nose
#3
Pau-Chung Chen, Hsin-Yi Peng, Che-Jui Chang, Hsiao-Yu Yang
Breath analyses have attracted substantial attention as screens for occupational environmental lung disease. The objective of this study was to develop breath tests for pneumoconiosis by analysing volatile organic compounds using an electronic nose. A case-control study was designed. We screened 102 subjects from a cohort of stone workers. After excluding three subjects with poorly controlled diabetes mellitus and one subject with asthma, 98 subjects were enrolled, including 34 subjects with pneumoconiosis and 64 healthy controls...
August 10, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28780807/-the-causes-of-hypokalemia-during-whole-lung-lavage-of-pneumoconiosis
#4
Y X Sun, G X Ma
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780801/-a-case-of-welder-s-pneumoconiosis-misdiagnosed-as-extrinsic-allergic-alveolitis
#5
H Xiao, Y Gao, P P Song
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780799/-a-report-on-10-occupational-pneumoconiosis-cases-in-a-rare-earth-refinery
#6
K J Jia, L L Wang, Y P He
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28766124/human-lung-injury-following-exposure-to-humic-substances-and-humic-like-substances
#7
REVIEW
Andrew J Ghio, Michael C Madden
Among the myriad particles the human respiratory tract is exposed to, a significant number are distinctive in that they include humic substances (HS) and humic-like substances (HULIS) as organic components. HS are heterogeneous, amorphous, organic materials which are ubiquitous occurring in all terrestrial and aqueous environments. HULIS are a complex class of organic, macromolecular compounds initially extracted from atmospheric aerosol particles which share some features with HS including an aromatic, polyacidic nature...
August 1, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28745030/cause-specific-mortality-and-cancer-morbidity-in-390-male-workers-exposed-to-high-purity-talc-a-six-decade-follow-up
#8
Ebba Wergeland, Finn Gjertsen, Linda Vos, Tom K Grimsrud
BACKGROUND: This study updates information on mortality and cancer morbidity in a cohort of Norwegian talc workers. METHODS: Follow-up was extended with 24 years, covering 1953-2011. Comparisons were made with the general population and between subgroups within the cohort. RESULTS: Standardized mortality ratio for non-malignant respiratory disease (NMRD) was 0.38 (95%CI: 0.18, 0.69) and for diseases of the circulatory system (CVD) 0.98 (95%CI: 0...
July 26, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28727677/surveillance-for-silicosis-deaths-among-persons-aged-15-44-years-united-states-1999-2015
#9
Jacek M Mazurek, John M Wood, Patricia L Schleiff, David N Weissman
Silicosis is usually a disease of long latency affecting mostly older workers; therefore, silicosis deaths in young adults (aged 15-44 years) suggests acute or accelerated disease.* To understand the circumstances surrounding silicosis deaths among young persons, CDC analyzed the underlying and contributing causes(†) of death using multiple cause-of-death data (1999-2015) and industry and occupation information abstracted from death certificates (1999-2013). During 1999-2015, among 55 pneumoconiosis deaths of young adults with International Classification of Diseases, Tenth Revision (ICD-10) code J62 (pneumoconiosis due to dust containing silica),(§) 38 (69%) had code J62...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28724562/the-role-of-macrophages-in-interstitial-lung-diseases-number-3-in-the-series-pathology-for-the-clinician-edited-by-peter-dorfm%C3%A3-ller-and-alberto-cavazza
#10
Giulio Rossi, Alberto Cavazza, Paolo Spagnolo, Salvatore Bellafiore, Elisabetta Kuhn, Pierpaolo Carassai, Laura Caramanico, Gloria Montanari, Gaia Cappiello, Alessandro Andreani, Francesca Bono, Nazarena Nannini
The finding of collections of macrophages/histiocytes in lung biopsy and bronchoalveolar lavage is relatively common in routine practice. This morphological feature in itself is pathological, but the exact clinical significance and underlying disease should be evaluated together with clinical data, functional respiratory and laboratory tests and imaging studies.Morphological characteristics of macrophages and their distribution along the different pulmonary structures should be examined carefully by pathologists...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28698801/tak1-inhibition-attenuates-both-inflammation-and-fibrosis-in-experimental-pneumoconiosis
#11
Jie Li, Chao Liang, Zong-Kang Zhang, Xiaohua Pan, Songlin Peng, Wing-Sze Lee, Aiping Lu, Zhixiu Lin, Ge Zhang, Wing-Nang Leung, Bao-Ting Zhang
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events in pneumoconiosis. Here, we performed microarrays to identify aberrantly expressed genes in the above molecular events in vitro and found a hub gene transforming growth factor-β-activated kinase 1 (TAK1), which was highly expressed and activated in pneumoconiosis patients as well as silica-exposed rats with experimental pneumoconiosis...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28698398/tnfr-tnf-%C3%AE-signaling-pathway-regulates-apoptosis-of-alveolar-macrophages-in-coal-workers-pneumoconiosis
#12
Qing-Zeng Qian, Xiang-Ke Cao, Hai-Yan Liu, Guo-Ying Zheng, Qing-Qiang Qian, Fu-Hai Shen
We explored the role of TNFR/TNF-α signalingin apoptosis among alveolar macrophages (AM) and its relevance to the development of coal workers' pneumoconiosis (CWP). Purified alveolar macrophages (AMs) were prepared from bronchoalveolar lavage fluid harvested from 366 CWP patients and 120 healthy subjects enrolled inthe study. The purified AMs were then divided into control, SOD, anti-TNFR, TNFR and NFkB inhibitor groups and analyzed for apoptosis usingflow cytometry (sub-diploid peak) and western blotting (Bcl-2, Caspase-3 and Caspase-8 expression)...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28691999/mortality-of-talc-miners-and-millers-from-val-chisone-northern-italy-an-updated-cohort-study
#13
Enrico Pira, Maurizio Coggiola, Catalina Ciocan, Canzio Romano, Carlo La Vecchia, Claudio Pelucchi, Paolo Boffetta
OBJECTIVE: The aim of this study was to update the analysis of mortality of a cohort of talc miners and millers in Northern Italy. METHODS: We analyzed the mortality during 1946 to 2013 of 1722 male workers in an asbestos-free talc mine (1166 miners and 556 millers) employed during 1946 to 1995. RESULTS: The overall standardized mortality ratio (SMR) was 1.24 [95% confidence interval (95% CI) 1.17 to 1.32]; no deaths were observed from pleural cancer; mortality from lung cancer was not increased...
July 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28689212/coal-mine-dust-desquamative-chronic-interstitial-pneumonia-a-precursor-of-dust-related-diffuse-fibrosis-and-of-emphysema
#14
Tomislav M Jelic, Oscar C Estalilla, Phyllis R Sawyer-Kaplan, Milton J Plata, Jeremy T Powers, Mary Emmett, John T Kuenstner
BACKGROUND: Diseases associated with coal mine dust continue to affect coal miners. Elucidation of initial pathological changes as a precursor of coal dust-related diffuse fibrosis and emphysema, may have a role in treatment and prevention. OBJECTIVE: To identify the precursor of dust-related diffuse fibrosis and emphysema. METHODS: Birefringent silica/silicate particles were counted by standard microscope under polarized light in the alveolar macrophages and fibrous tissue in 25 consecutive autopsy cases of complicated coal worker's pneumoconiosis and in 21 patients with tobacco-related respiratory bronchiolitis...
July 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28621697/innovation-systemic-appropriation-and-prevention-in-the-granite-mining-sector-the-case-of-humidification
#15
R W B Mendes, V Pueyo, P Béguin, F J C M Duarte
BACKGROUND: This research was conducted in the Brazilian granite mining sector. After epidemiological studies, it was established that professional pneumoconiosis is related to the inhalation of dust. Therefore, the Brazilian mining health and safety regulatory standard made it compulsory to provide humidification throughout the extraction and mineral treatment processes. OBJECTIVE: To develop the concept of systemic appropriation of the technological innovations that aim to protect the worker's health...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28614935/-clinical-observation-of-external-diaphragm-pacing-in-patients-with-pneumoconiosis-complicated-with-chronic-obstructive-pulmonary-disease-in-stable-stage
#16
P Jiang, X C Liu, L L Ma
No abstract text is available yet for this article.
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28598937/increasing-severity-of-pneumoconiosis-among-younger-former-us-coal-miners-working-exclusively-under-modern-dust-control-regulations
#17
Judith M Graber, Gerald Harris, Kirsten S Almberg, Cecile S Rose, Edward L Petsonk, Robert A Cohen
BACKGROUND: Coal workers' pneumoconiosis (CWP) steadily declined among US miners following dust control regulations in 1970. In 2000, severe forms of this disease reemerged among young miners, and are well described among working-but not former-miners. METHODS: Black lung benefits program (BLBP) data (2001 to 2013) were used to estimate respiratory disease burden among former miners including: (1) CWP (simple; advanced CWP, and progressive massive fibrosis [CWP/PMF]); and (2) respiratory impairment (FEV1 percent reference: mild, moderate, ≥moderately-severe)...
June 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28514304/diagnostic-and-clinical-application-value-of-magnetic-resonance-imaging-mri-for-progressive-massive-fibrosis-of-coal-worker-pneumoconiosis-case-reports
#18
Lansheng Zhang, Chun Wang, Qiuyue Yan, Tao Zhang, Zhengxiang Han, Guan Jiang
RATIONALE: Using magnetic resonance imaging (MRI), we diagnosed pneumoconiosis by identifying the content and distribution of hydrogen protons in the water molecules in different tissues and lesions. PATIENT CONCERNS: 25 cases of CWP patients with progressive massive fibrosis (PMF) lesions. DIAGNOSES: Patients were correctly diagnosed, with one case each of Phase I and II pneumoconiosis and 23 cases of Phase III pneumoconiosis. INTERVENTIONS: None...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28497853/respiratory-morbidity-among-u-s-coal-miners-in-states-outside-of-central-appalachia
#19
Laura E Reynolds, David J Blackley, Anthony S Laney, Cara N Halldin
BACKGROUND: Recent NIOSH publications have focused on the respiratory health of coal miners in central Appalachia, yet 57% of U.S. coal miners work in other regions. We characterized respiratory morbidity in coal miners from these regions. METHODS: Active coal miners working outside of central Appalachia who received chest radiographs and/or spirometry during 2005-2015 were included. Chest radiographs were classified according to International Labour Office standards and spirometry was interpreted using the American Thoracic Society guidelines...
May 12, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28481235/survival-analysis-of-coal-workers-pneumoconiosis-cwp-patients-in-a-state-owned-mine-in-the-east-of-china-from-1963-to-2014
#20
Lei Han, Qianqian Gao, Jingjin Yang, Qiuyun Wu, Baoli Zhu, Hengdong Zhang, Bangmei Ding, Chunhui Ni
To investigate the mortality probability, life expectancy of coal workers' pneumoconiosis (CWP), and related factors of life expectancy, a total of 495 patients with CWP were diagnosed and reported from 1963 to 2014 in a state-owned mine in the east of China. The life table method, log rank method, and Cox regression model were used for survival analysis. 95 out of 495 CWP died during this period. The mortality rate was 19.19%. The average life span was 12.1 (0.0-33.2) years and average death age was 57.4 (33...
May 6, 2017: International Journal of Environmental Research and Public Health
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