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Pneumoconiosis

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https://www.readbyqxmd.com/read/29465110/james-craufurd-gregory-19th-century-scottish-physicians-and-the-link-between-occupation-as-a-coal-miner-and-lung-disease
#1
K Donaldson, W A Wallace, T A Elliot, C Henry
By the mid-19th century about 200,000 miners were employed in a UK coal mining industry still growing with the advances of the Industrial Revolution. Coal miners were long known to suffer poor health but the link to inhaling dust in the mines had not been made. In 1813 George Pearson was the first to suggest that darkening of lungs seen in normal individuals as they aged was caused by inhaled soot from burning oil, candles and coal, which were the common domestic sources of heat and light. In 1831 Dr James Craufurd Gregory first described black pigmentation and disease in the lungs of a deceased coal miner and linked this to pulmonary accumulation of coal mine dust...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29438277/a-response-to-the-comment-on-tomaskova-et-al-mortality-in-miners-with-coal-workers-pneumoconiosis-in-the-czech-republic-in-the-period-1992-2013-int-j-environ-res-public-health-2017-14-269-by-the-author-mei-yong
#2
Hana Tomášková, Anna Šplíchalová, Hana Šlachtová, Daniela Pelclová, Pavel Urban, Zdeněk Jirák
At first, we would like to thank Mei Yong for the comments on our article Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013 [...].
February 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29423227/silica-exposure-and-work-relatedness-evaluation-for-occupational-cancer-in-korea
#3
REVIEW
Hyoung-Ryoul Kim, Boowook Kim, Bum Seak Jo, Ji-Won Lee
Crystalline silica has been classified as a definite carcinogen (Group 1) causing lung cancer by the International Agency for Research on Cancer (IARC). In Korea, crystalline silica has been the most common causal agent for workers to apply to the Korea Workers' Compensation and Welfare Service (KWCWS). We used KWCWS data to evaluate workers' crystalline silica exposure levels according to their occupations and industries, and reviewed research papers describing the dose-response relationship between cumulative exposure levels and lung cancer incidence...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29416696/tnfr-tnf-%C3%AE-signaling-pathway-regulates-apoptosis-of-alveolar-macrophages-in-coal-workers-pneumoconiosis
#4
Qing-Zeng Qian, Xiang-Ke Cao, Hai-Yan Liu, Guo-Ying Zheng, Qing-Qiang Qian, Fu-Hai Shen
We explored the role of TNFR/TNF-α signalingin apoptosis among alveolar macrophages (AM) and its relevance to the development of coal workers' pneumoconiosis (CWP). Purified alveolar macrophages (AMs) were prepared from bronchoalveolar lavage fluid harvested from 366 CWP patients and 120 healthy subjects enrolled inthe study. The purified AMs were then divided into control, SOD, anti-TNFR, TNFR and NFkB inhibitor groups and analyzed for apoptosis usingflow cytometry (sub-diploid peak) and western blotting (Bcl-2, Caspase-3 and Caspase-8 expression)...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415464/comment-on-tomaskova-et-al-mortality-in-miners-with-coal-workers-pneumoconiosis-in-the-czech-republic-in-the-period-1992-2013-int-j-environ-res-public-health-2017-14-269
#5
Mei Yong
With interest, I read the recent analysis by Tomaskova and co-workers (2017) about mortality from coal workers' pneumoconiosis (CWP). The research question remains unclear whether coal workers' pneumoconiosis (CWP) resulting from exposure to respirable coal dust containing crystalline silica accelerates the development of lung cancer or whether it is an intermediate stage in the pathway. I made several points of considerations with respect to (1) qualified data; (2) alternate measures for excessive risks; and (3) methodological flaws that should be avoided...
February 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29394417/association-analysis-identifies-new-risk-loci-for-coal-workers-pneumoconiosis-in-han-chinese-men
#6
Ting Wang, Yan Li, Meng Zhu, Wenxi Yao, Hongyan Wu, Xiaoming Ji, Zhibin Hu, Hongbing Shen, Xiangshan Fan, Chunhui Ni
Coal worker's pneumoconiosis (CWP) is a debilitating and progressive occupational lung disease resulted from long-term inhalation of airborne silica-containing coal mine dust. Both environmental factors and genetic variations contribute to CWP. Our previous genome-wide association study (GWAS) revealed a tiny fraction of variants with the top associations in Chinese Han population. To identify novel susceptibility loci of CWP, functional variants with suboptimal associations in the GWAS scan were further studied here...
January 31, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29378587/prevalence-and-characteristics-of-copd-among-pneumoconiosis-patients-at-an-occupational-disease-prevention-institute-a-cross-sectional-study
#7
Yating Peng, Xin Li, Shan Cai, Yan Chen, Weirong Dai, Wenfeng Liu, Zijing Zhou, Jiaxi Duan, Ping Chen
BACKGROUND: Pneumoconiosis may play an important role in the development of chronic obstructive pulmonary disease (COPD), and the complication of COPD may impose a heavy burden of illness. METHODS: The study was conducted in Hunan Province in China from December 1, 2015, to December 1, 2016. Consecutive underground male pneumoconiosis patients employed for at least 1 year were recruited from the Hunan Occupational Disease Prevention Institute. Patient information, respiratory symptoms and clinical data were collected using a structured questionnaire...
January 29, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29378067/associations-of-polymorphisms-in-the-cytokine-genes-il1%C3%AE-rs16944-il6-rs1800795-il12b-rs3212227-and-growth-factor-vegfa-rs2010963-with-anthracosilicosis-in-coal-miners-in-russia-and-related-genotoxic-effects
#8
Valentin P Volobaev, Aleksey V Larionov, Ekaterina E Kalyuzhnaya, Ekaterina S Serdyukova, Svetlana Yakovleva, Vladimir G Druzhinin, Olga O Babich, Elena G Hill, Victor A Semenihin, Nikolay I Panev, Varvara I Minina, Saravana Devi Sivanesan, Pravin Naoghare, Juliana da Silva, Gustavo R M Barcelos, Alexander Y Prosekov
Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms were genotyped in the extracted DNA samples: IL1β T-511C (rs16944), IL6 C-174G (rs1800795), IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963)...
January 25, 2018: Mutagenesis
https://www.readbyqxmd.com/read/29316765/-analysis-of-clinical-features-in-patients-with-pneumoconiosis-complicated-with-pulmonary-emphysema
#9
X Li, W R Dai, L Li, W F Liu, Z X Yang, L Xie
Objective: To investigate the clinical features of pneumoconiosis complicated with pulmo-nary emphysema. Methods: selected 868 patients with pneumoconiosis were selected from December 2015 to December 2016 in Hunan occupational disease prevention and treatment hospital. Collected the results of high-resolution spiral CT, arterial blood gas, ECG, pulmonary function and MRC score. The subjects were divided into pneumoconiosis complicated with pulmonary emphysema group and simple pneumoconiosis group accord-ing to the results of HRCT...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29316754/-detection-of-metals-and-metalloids-in-the-lavage-fluid-of-whole-lung-lavage-of-the-cases-of-pneumoconiosis
#10
K Wen, C G Ding, G Chen, G X Ma, H Q Wang
Objective: To detect of the components and concentration of the metals and metalloids in the lavage fluid of whole-lung lavage (WLL) of the cases of pneumoconiosis, and analyze the characteristics, and explore the method to sample and process the samples of bronchoalveolar lavage fluid (BAL) . Methods: The samples of urine and serum of three cases of pneumoconiosis were collected before WLL, and the samples of BAL were collected during the WLL from the left and right lungs according to the sequence of four pressured gas flow and five negative pressure drainage...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29316748/-preliminary-study-of-exon-sequence-in-pneumoconiosis-and-pneumoconiosis-complicated-with-lung-cancer-using-high-throughput-sequencing-technology
#11
M F Jiang, L Li, Z Wang, C L Zhang, H Zhang
Objective: The detection and analysis of exon mutations of pneumoconiosis and pneumoco-niosis complicated with lung cancer provide reference evidence for screening, clinical diagnosis and treatment and prognosis in pneumoconiosis and pneumoconiosis complicated with lung cancer. Methods: The pathologi-cal tissue samples from 3 pneumoconiosis patients and 3 pneumoconiosis complicated with lung cancer pa-tients were collected. Genomic DNA was extracted and library was prepared. Exomes of the pathological tissue samples in pneumoconiosis patients and pneumoconiosis complicated with lung cancer patients were se-quenced using Ion Torrent PGM platform...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29297856/silicosis-mortality-in-italy-temporal-trends-1990-2012-and-spatial-patterns-2000-2012
#12
Giada Minelli, Amerigo Zona, Fulvio Cavariani, Pietro Comba, Roberto Pasetto
INTRODUCTION: The objective of this contribution is to describe, for the first time, occurrence, temporal trends and spatial patterns of mortality from silicosis in Italy in recent decades. METHODS: Mortality data on pneumoconiosis due to silica or silicates (ICD-9 code 502, ICD-10 code J62) were extracted from the Italian National Mortality Database. Temporal trends were analysed in the period 1990-2012; standardized rates per 100 000, spatial distribution, including cluster analysis, were computed for eleven years, i...
October 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29294518/-study-of-the-association-between-interleukin-1-polymorphisms-and-genetic-susceptibility-of-coal-workers-pneumoconiosis-and-silicosis
#13
W Wang, W H Zhang, Y S Tao, X Zhuang, M J Chu
Objective: To evaluate the relationship between IL-1 gene polymorphisms and coal workers' pneumoconiosis and silicosis susceptibility. Methods: We searched published full-text from PubMed, Web of Science, CNKI, VIP and Wanfang to collect case-control study on IL-1 gene polymorphisms with coal workers' pneumoconiosis and silicosis susceptibility. Eight articles, including 10 case-control studies were included in our study. All analyses were performed using the Stata version 12.0 software. Results: The IL-1RA (+2018) TC or CC variant genotypes were associated with coal workers' pneumoconiosis and silicosis risk (OR=1...
September 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29284684/chest-physician-reported-work-related-long-latency-respiratory-disease-in-great%C3%A2-britain
#14
Melanie Carder, Andrew Darnton, Matthew Gittins, S Jill Stocks, David Ross, Chris M Barber, Raymond M Agius
Much of the current burden of long-latency respiratory disease (LLRD) in Great Britain is attributed to historical asbestos exposure. However, continuing exposure to other agents, notably silica, also contributes to disease burden. The aim of this study was to investigate the incidence of work-related LLRD reported by chest physicians in Great Britain, including variations by age, gender, occupation and suspected agent.LLRD incidence and incidence rate ratios by occupation were estimated (1996-2014). Mesothelioma cases by occupation were compared with proportional mortality ratios...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29274923/erratum-to-wood-charcoal-dust-pneumoconiosis
#15
P P T S Torres, E Marchiori, S A Pinto, M F Rabahi
No abstract text is available yet for this article.
November 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29243467/high-resolution-ct-of-the-lungs-indications-and-diagnosis
#16
REVIEW
Helena Lauri
High-resolution computed tomography (HRCT) is a method of examination which is more precise than chest 2-rat in the diagnosis and monitoring of diseases of the lung tissue and the airways. Modern CT equipment enables a volume HRCT scan covering the whole lung tissue. HRCT slices can also be constructed from contrast-enhanced CT scans of the chest of the whole body. HRCT of the lungs can be applied to the diagnosis of both acute and more chronic diffuse diseases of the lung tissue and the airways. The best-known indications for HRCT include idiopathic interstitial pneumonias, such as idiopathic pulmonary fibrosis...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29225839/a-case-of-empyema-and-septic-arthritis-due-to-nocardia-farcinica
#17
Takashi Ishiguro, Hiroaki Yoshioka, Shoko Kawai, Shin-Ichi Katsumata, Tohru Gonoi, Noboru Takayanagi
Septic arthritis due to Nocardia sp. should be suspected when a patient with risk factors such as pneumoconiosis or diabetes mellitus develops joint symptoms, especially if the patient has had nocardiosis in other sites.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29210092/comparison-of-digital-and-film-chest-radiography-for-detection-and-medical-surveillance-of-silicosis-in-a-setting-with-a-high-burden-of-tuberculosis
#18
Alfred Franzblau, Jim teWaterNaude, Ananda Sen, Hannah d'Arcy, Jacqueline S Smilg, Khanyakude S Mashao, Cristopher A Meyer, James E Lockey, Rodney I Ehrlich
BACKGROUND: Continuing use of analog film and digital chest radiography for screening and surveillance for pneumoconiosis and tuberculosis in lower and middle income countries raises questions of equivalence of disease detection. This study compared analog to digital images for intra-rater agreement across formats and prevalence of changes related to silicosis and tuberculosis among South African gold miners using the International Labour Organization classification system. METHODS: Miners with diverse radiological presentations of silicosis and tuberculosis were recruited...
December 6, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29202602/clinical-significance-of-serum-anti-gm-csf-autoantibody-levels-in-autoimmune-pulmonary-alveolar-proteinosis
#19
Masaki Nishimura, Etsuro Yamaguchi, Ayumu Takahashi, Nobuhiro Asai, Eisuke Katsuda, Toyohiro Ohta, Yoshinori Ohtsuka, Kenshi Kosaka, Ayako Matsubara, Hiroyuki Tanaka, Norihito Yokoe, Akihito Kubo, Satoshi Konno, Kenji Baba
AIM: Precise clinical significance of antigranulocyte-macrophage colony stimulating factor (GM-CSF) autoantibody levels in autoimmune pulmonary alveolar proteinosis (aPAP) has not been well studied. METHODS: We obtained sera from 50 healthy controls, 46 aPAP patients, 50 with sarcoidosis, 52 with idiopathic interstitial pneumonia and 75 with pneumoconiosis. The clinical course of aPAP patients was assessed by scoring computed tomography images in 19 patients. RESULTS: The cut-off level of anti-GM-CSF IgG for discrimination between aPAP and other diffuse lung diseases was 2...
December 5, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29200837/the-relationship-of-ssri-and-snri-usage-with-interstitial-lung-disease-and-bronchiectasis-in-an-elderly-population-a-case-control-study
#20
Ted Rosenberg, Rory Lattimer, Patrick Montgomery, Christian Wiens, Liran Levy
Background: The association between interstitial lung disease (ILD) and selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors (SSRI/SNRI) has been previously described in published case reports. However, its prevalence may be more common than expected. We examined the association between SSRI/SNRI usage and presence of ILD and or bronchiectasis (ILD/B) in an elderly population. Methods: We conducted a retrospective case series and case-control study involving all 296 eligible elderly patients in one primary care geriatric practice in Victoria, BC, Canada...
2017: Clinical Interventions in Aging
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