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Pneumoconiosis

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https://www.readbyqxmd.com/read/29021460/a-case-of-dental-technicians-pneumoconiosis
#1
Masaki Okamoto, Masaki Tominaga, Shigeki Shimizu, Chiyo Yano, Ken Masuda, Masayuki Nakamura, Yoshiaki Zaizen, Takashi Nouno, Satoshi Sakamoto, Mitsuru Yokoyama, Tomotaka Kawayama, Tomoaki Hoshino
A 40-year-old female dental technician visited our hospital for the investigation of a chest X-ray abnormality. Chest computed tomography demonstrated centrilobular nodules and lung volume reduction, and her serum KL-6 level was elevated. A histological analysis of the specimens obtained on a surgical lung biopsy showed peribronchiolar fibrosis with pigmented macrophages and cholesterol clefts. An energy-dispersive X-ray analysis showed that these lung tissues contained some metals, including indium. The serum indium level was also elevated...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28973621/trends-and-patterns-of-differences-in-chronic-respiratory-disease-mortality-among-us-counties-1980-2014
#2
Laura Dwyer-Lindgren, Amelia Bertozzi-Villa, Rebecca W Stubbs, Chloe Morozoff, Shreya Shirude, Mohsen Naghavi, Ali H Mokdad, Christopher J L Murray
Importance: Chronic respiratory diseases are an important cause of death and disability in the United States. Objective: To estimate age-standardized mortality rates by county from chronic respiratory diseases. Design, Setting, and Participants: Validated small area estimation models were applied to deidentified death records from the National Center for Health Statistics and population counts from the US Census Bureau, National Center for Health Statistics, and Human Mortality Database to estimate county-level mortality rates from 1980 to 2014 for chronic respiratory diseases...
September 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28963659/squamous-cell-carcinoma-of-the-lung-showing-a-ground-glass-nodule-on-high-resolution-computed-tomography-associated-with-pneumoconiosis-a-case-report
#3
Yuriko Terada, Masaaki Sato, Hiroyuki Abe, Hideki Kuwano, Kazuhiro Nagayama, Jun-Ichi Nitadori, Masaki Anraku, Jun Nakajima
BACKGROUND: Adenocarcinoma with lepidic growth pattern presents as a ground glass nodule (GGN) on high resolution computed tomography (CT), whereas peripheral pulmonary squamous cell carcinoma (SCC) usually presents as a solid nodule. We herein report a rare case of pulmonary SCC extending along the alveolar lumen representing as a GGN on a CT scan in a patient with pneumoconiosis. CASE PRESENTATION: A 77-year-old man with pneumoconiosis was found to have a gradually enlarging GGN in the right lower lobe of the lung on CT...
September 29, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28953250/lrba-gene-polymorphisms-and-risk-of-coal-workers-pneumoconiosis-a-case-control-study-from-china
#4
Yi Liu, Jingjin Yang, Qiuyun Wu, Ruhui Han, Weiwen Yan, Jiali Yuan, Xiaoming Ji, Yan Li, Wenxi Yao, Chunhui Ni
The lipopolysaccharide (LPS)-responsive beige-like anchor protein (LRBA) is a member of the WDL-BEACH-WD (WBW) gene family. Defects in this gene are associated with the disordered autoimmunity in various diseases, including pulmonary fibrosis. In this study, we investigated the association between the functional polymorphisms in LRBA and risk of coal workers' pneumoconiosis (CWP) in a Chinese population. Three potentially functional polymorphisms (rs2290846, rs3749574, and rs1782360) in LRBA were genotyped and analyzed in a case-control study, including 703 CWP cases and 705 controls...
September 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28932549/statins-may-be-beneficial-for-patients-with-pulmonary-hypertension-secondary-to-lung-diseases
#5
Ming-Zhou Zhang, De-Hui Qian, Jian-Cheng Xu, Wei Yao, Ye Fan, Chang-Zheng Wang
BACKGROUND: Previous animal studies and clinical trials report inconsistent findings regarding the role of statins in pulmonary hypertension (PH). Systematic reviews have shown no use of statins on pulmonary arterial hypertension (PAH). This is the first meta-analysis of randomized controlled trials (RCTs) determining the clinical impacts of statin therapy on patients with PH secondary to lung diseases. METHODS: Electronic databases and manual bibliographical searches were conducted...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28913840/loss-of-regulatory-characteristics-in-cd4-cd25-hi-t-cells-induced-by-impaired-transforming-growth-factor-beta-secretion-in-pneumoconiosis
#6
Lu-Qin Bian, Ling Mao, Ying Bi, Shao-Wei Zhou, Zi-Dan Chen, Jun Wen, Jin Shi, Ling Wang
Pneumoconiosis is caused by the accumulation of airborne dust in the lung, which stimulates a progressive inflammatory response that ultimately results in lung fibrosis and respiratory failure. It is possible that regulatory cells in the immune system could function to suppress inflammation and possibly slow or reverse disease progression. However, results in this study suggest that in pneumoconiosis patients, the regulatory T cells (Tregs) and B cells are functionally impaired. First, we found that pneumoconiosis patients presented an upregulation of CD4(+) CD25(+) T cells compared to controls, whereas the CD4(+) CD25(+) and CD4(+) CD25(hi) T cells were enriched with Th1- and Th17-like cells but not Foxp3-expressing Treg cells and evidenced by significantly higher T-bet, interferon (IFN)-γ, and interleukin (IL)-17 expression but lower Foxp3 and transforming growth factor (TGF)-β expression...
September 15, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28912379/element-based-prognostics-of-occupational-pneumoconiosis-using-micro-proton-induced-x-ray-emission-analysis
#7
Xiaodong He, Hao Shen, Zidan Chen, Caicai Rong, Minqin Ren, Likun Hou, Chunyan Wu, Ling Mao, Quan Lu, B O Su
Pneumoconiosis is an occupational disease accompanied by long-term lung impairment for which prediction of prognosis is poorly understood because of the complexity of the inhaled particles. Micro-proton-induced X-ray emission (micro-PIXE) analysis, which is advantageous for high-sensitivity 2D element mapping of lung tissues, was used to investigate element-based predictive factors of prognosis in Chinese patients with welder's and coal miner's pneumoconiosis. Chest radiographs and lung function tests showed that most of the coal miners deteriorated, while symptoms in some welders were alleviated after five years, as determined by comparing percent vital capacity (VC%) and forced expiratory volume in the first second over forced vital capacity (FEV1...
September 14, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28844669/polymorphisms-in-autophagy-related-genes-and-the-coal-workers-pneumoconiosis-in-a-chinese-population
#8
Jiali Yuan, Ruhui Han, Ayaaba Esther, Qiuyun Wu, Jingjin Yang, Weiwen Yan, Xiaoming Ji, Yi Liu, Yan Li, Wenxi Yao, Chunhui Ni
Autophagy is an evolutionary conserved intracellular degradation/recycling system that is essential for cellular homeostasis. Dysregulation of this process leads to a number of disorders, including pulmonary fibrosis. However, the genetic association between singe nucleotide polymorphisms of autophagy related genes (ATGs) and the risk of coal workers' pneumoconiosis has not been reported yet. Total of 7 SNPs in ATGs (ATG16, ATG12, ATG5, ATG10) were investigated for their roles in CWP by a case-control study which including 705 CWP patients and 703 control subjects...
October 20, 2017: Gene
https://www.readbyqxmd.com/read/28806260/68ga-psma-ligand-pet-ct-uptake-in-anthracosilicosis
#9
Madeleine McGuiness, Brett Sounness
This interesting image illustrates a case of biopsy-proven pulmonary anthracosilicosis, a mixed dust pneumoconiosis, associated with Ga-PSMA-ligand uptake. Prostate-specific membrane antigen (PSMA) is an emerging imaging biomarker, with clinical application in evaluation of prostate cancer using Ga-PSMA-ligand PET/CT. Contrary to its name, PSMA is expressed in a number of other normal tissues and pathological states. Prostate-specific membrane antigen expression has been linked to tumor angiogenesis in various other epithelial neoplasms, as well as neovasculature associated with tissue regeneration and repair...
October 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28801410/radiographic-features-of-importance-in-the-national-institute-for-occupational-safety-and-health-administered-coal-workers-health-surveillance-program-characterising-the-use-of-the-other-symbols
#10
Cara N Halldin, Janet M Hale, David J Blackley, A Scott Laney
OBJECTIVE: The National Institute for Occupation Safety and Health-administered Coal Workers' Health Surveillance Program (CWHSP) provides radiographic pneumoconiosis screening for US coal miners. Radiographs are classified by readers according to International Labour Office criteria. In addition to pneumoconiotic parenchymal and pleural lung abnormalities, readers document radiographic features of importance (other symbols). Other symbols are not meant to imply a diagnosis or interpretation but are relevant as they provide information beyond a pneumoconiosis classification for features related to dust exposure and other aetiologies...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28795953/diagnostic-accuracy-of-breath-tests-for-pneumoconiosis-using-an-electronic-nose
#11
Pau-Chung Chen, Hsin-Yi Peng, Che-Jui Chang, Hsiao-Yu Yang
Breath analyses have attracted substantial attention as screens for occupational environmental lung disease. The objective of this study was to develop breath tests for pneumoconiosis by analysing volatile organic compounds using an electronic nose. A case-control study was designed. We screened 102 subjects from a cohort of stone workers. After excluding three subjects with poorly controlled diabetes mellitus and one subject with asthma, 98 subjects were enrolled, including 34 subjects with pneumoconiosis and 64 healthy controls...
August 10, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28780807/-the-causes-of-hypokalemia-during-whole-lung-lavage-of-pneumoconiosis
#12
Y X Sun, G X Ma
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780801/-a-case-of-welder-s-pneumoconiosis-misdiagnosed-as-extrinsic-allergic-alveolitis
#13
H Xiao, Y Gao, P P Song
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780799/-a-report-on-10-occupational-pneumoconiosis-cases-in-a-rare-earth-refinery
#14
K J Jia, L L Wang, Y P He
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28766124/human-lung-injury-following-exposure-to-humic-substances-and-humic-like-substances
#15
REVIEW
Andrew J Ghio, Michael C Madden
Among the myriad particles the human respiratory tract is exposed to, a significant number are distinctive in that they include humic substances (HS) and humic-like substances (HULIS) as organic components. HS are heterogeneous, amorphous, organic materials which are ubiquitous occurring in all terrestrial and aqueous environments. HULIS are a complex class of organic, macromolecular compounds initially extracted from atmospheric aerosol particles which share some features with HS including an aromatic, polyacidic nature...
August 1, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28745030/cause-specific-mortality-and-cancer-morbidity-in-390-male-workers-exposed-to-high-purity-talc-a-six-decade-follow-up
#16
Ebba Wergeland, Finn Gjertsen, Linda Vos, Tom K Grimsrud
BACKGROUND: This study updates information on mortality and cancer morbidity in a cohort of Norwegian talc workers. METHODS: Follow-up was extended with 24 years, covering 1953-2011. Comparisons were made with the general population and between subgroups within the cohort. RESULTS: Standardized mortality ratio for non-malignant respiratory disease (NMRD) was 0.38 (95%CI: 0.18, 0.69) and for diseases of the circulatory system (CVD) 0.98 (95%CI: 0...
July 26, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28727677/surveillance-for-silicosis-deaths-among-persons-aged-15-44-years-united-states-1999-2015
#17
Jacek M Mazurek, John M Wood, Patricia L Schleiff, David N Weissman
Silicosis is usually a disease of long latency affecting mostly older workers; therefore, silicosis deaths in young adults (aged 15-44 years) suggests acute or accelerated disease.* To understand the circumstances surrounding silicosis deaths among young persons, CDC analyzed the underlying and contributing causes(†) of death using multiple cause-of-death data (1999-2015) and industry and occupation information abstracted from death certificates (1999-2013). During 1999-2015, among 55 pneumoconiosis deaths of young adults with International Classification of Diseases, Tenth Revision (ICD-10) code J62 (pneumoconiosis due to dust containing silica),(§) 38 (69%) had code J62...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28724562/the-role-of-macrophages-in-interstitial-lung-diseases-number-3-in-the-series-pathology-for-the-clinician-edited-by-peter-dorfm%C3%A3-ller-and-alberto-cavazza
#18
Giulio Rossi, Alberto Cavazza, Paolo Spagnolo, Salvatore Bellafiore, Elisabetta Kuhn, Pierpaolo Carassai, Laura Caramanico, Gloria Montanari, Gaia Cappiello, Alessandro Andreani, Francesca Bono, Nazarena Nannini
The finding of collections of macrophages/histiocytes in lung biopsy and bronchoalveolar lavage is relatively common in routine practice. This morphological feature in itself is pathological, but the exact clinical significance and underlying disease should be evaluated together with clinical data, functional respiratory and laboratory tests and imaging studies.Morphological characteristics of macrophages and their distribution along the different pulmonary structures should be examined carefully by pathologists...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28698801/tak1-inhibition-attenuates-both-inflammation-and-fibrosis-in-experimental-pneumoconiosis
#19
Jie Li, Chao Liang, Zong-Kang Zhang, Xiaohua Pan, Songlin Peng, Wing-Sze Lee, Aiping Lu, Zhixiu Lin, Ge Zhang, Wing-Nang Leung, Bao-Ting Zhang
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events in pneumoconiosis. Here, we performed microarrays to identify aberrantly expressed genes in the above molecular events in vitro and found a hub gene transforming growth factor-β-activated kinase 1 (TAK1), which was highly expressed and activated in pneumoconiosis patients as well as silica-exposed rats with experimental pneumoconiosis...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28698398/tnfr-tnf-%C3%AE-signaling-pathway-regulates-apoptosis-of-alveolar-macrophages-in-coal-workers-pneumoconiosis
#20
Qing-Zeng Qian, Xiang-Ke Cao, Hai-Yan Liu, Guo-Ying Zheng, Qing-Qiang Qian, Fu-Hai Shen
We explored the role of TNFR/TNF-α signalingin apoptosis among alveolar macrophages (AM) and its relevance to the development of coal workers' pneumoconiosis (CWP). Purified alveolar macrophages (AMs) were prepared from bronchoalveolar lavage fluid harvested from 366 CWP patients and 120 healthy subjects enrolled inthe study. The purified AMs were then divided into control, SOD, anti-TNFR, TNFR and NFkB inhibitor groups and analyzed for apoptosis usingflow cytometry (sub-diploid peak) and western blotting (Bcl-2, Caspase-3 and Caspase-8 expression)...
July 1, 2017: Oncotarget
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