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https://www.readbyqxmd.com/read/28727677/surveillance-for-silicosis-deaths-among-persons-aged-15-44-years-united-states-1999-2015
#1
Jacek M Mazurek, John M Wood, Patricia L Schleiff, David N Weissman
Silicosis is usually a disease of long latency affecting mostly older workers; therefore, silicosis deaths in young adults (aged 15-44 years) suggests acute or accelerated disease.* To understand the circumstances surrounding silicosis deaths among young persons, CDC analyzed the underlying and contributing causes(†) of death using multiple cause-of-death data (1999-2015) and industry and occupation information abstracted from death certificates (1999-2013). During 1999-2015, among 55 pneumoconiosis deaths of young adults with International Classification of Diseases, Tenth Revision (ICD-10) code J62 (pneumoconiosis due to dust containing silica),(§) 38 (69%) had code J62...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28724562/the-role-of-macrophages-in-interstitial-lung-diseases-number-3-in-the-series-pathology-for-the-clinician-edited-by-peter-dorfm%C3%A3-ller-and-alberto-cavazza
#2
Giulio Rossi, Alberto Cavazza, Paolo Spagnolo, Salvatore Bellafiore, Elisabetta Kuhn, Pierpaolo Carassai, Laura Caramanico, Gloria Montanari, Gaia Cappiello, Alessandro Andreani, Francesca Bono, Nazarena Nannini
The finding of collections of macrophages/histiocytes in lung biopsy and bronchoalveolar lavage is relatively common in routine practice. This morphological feature in itself is pathological, but the exact clinical significance and underlying disease should be evaluated together with clinical data, functional respiratory and laboratory tests and imaging studies.Morphological characteristics of macrophages and their distribution along the different pulmonary structures should be examined carefully by pathologists...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28698801/tak1-inhibition-attenuates-both-inflammation-and-fibrosis-in-experimental-pneumoconiosis
#3
Jie Li, Chao Liang, Zong-Kang Zhang, Xiaohua Pan, Songlin Peng, Wing-Sze Lee, Aiping Lu, Zhixiu Lin, Ge Zhang, Wing-Nang Leung, Bao-Ting Zhang
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events in pneumoconiosis. Here, we performed microarrays to identify aberrantly expressed genes in the above molecular events in vitro and found a hub gene transforming growth factor-β-activated kinase 1 (TAK1), which was highly expressed and activated in pneumoconiosis patients as well as silica-exposed rats with experimental pneumoconiosis...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28698398/tnfr-tnf-%C3%AE-signaling-pathway-regulates-apoptosis-of-alveolar-macrophages-in-coal-workers-pneumoconiosis
#4
Qing-Zeng Qian, Xiang-Ke Cao, Hai-Yan Liu, Guo-Ying Zheng, Qing-Qiang Qian, Fu-Hai Shen
We explored the role of TNFR/TNF-α signalingin apoptosis among alveolar macrophages (AM) and its relevance to the development of coal workers' pneumoconiosis (CWP). Purified alveolar macrophages (AMs) were prepared from bronchoalveolar lavage fluid harvested from 366 CWP patients and 120 healthy subjects enrolled inthe study. The purified AMs were then divided into control, SOD, anti-TNFR, TNFR and NFkB inhibitor groups and analyzed for apoptosis usingflow cytometry (sub-diploid peak) and western blotting (Bcl-2, Caspase-3 and Caspase-8 expression)...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28691999/mortality-of-talc-miners-and-millers-from-val-chisone-northern-italy-an-updated-cohort-study
#5
Enrico Pira, Maurizio Coggiola, Catalina Ciocan, Canzio Romano, Carlo La Vecchia, Claudio Pelucchi, Paolo Boffetta
OBJECTIVE: The aim of this study was to update the analysis of mortality of a cohort of talc miners and millers in Northern Italy. METHODS: We analyzed the mortality during 1946 to 2013 of 1722 male workers in an asbestos-free talc mine (1166 miners and 556 millers) employed during 1946 to 1995. RESULTS: The overall standardized mortality ratio (SMR) was 1.24 [95% confidence interval (95% CI) 1.17 to 1.32]; no deaths were observed from pleural cancer; mortality from lung cancer was not increased...
July 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28689212/coal-mine-dust-desquamative-chronic-interstitial-pneumonia-a-precursor-of-dust-related-diffuse-fibrosis-and-of-emphysema
#6
Tomislav M Jelic, Oscar C Estalilla, Phyllis R Sawyer-Kaplan, Milton J Plata, Jeremy T Powers, Mary Emmett, John T Kuenstner
BACKGROUND: Diseases associated with coal mine dust continue to affect coal miners. Elucidation of initial pathological changes as a precursor of coal dust-related diffuse fibrosis and emphysema, may have a role in treatment and prevention. OBJECTIVE: To identify the precursor of dust-related diffuse fibrosis and emphysema. METHODS: Birefringent silica/silicate particles were counted by standard microscope under polarized light in the alveolar macrophages and fibrous tissue in 25 consecutive autopsy cases of complicated coal worker's pneumoconiosis and in 21 patients with tobacco-related respiratory bronchiolitis...
July 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28621697/innovation-systemic-appropriation-and-prevention-in-the-granite-mining-sector-the-case-of-humidification
#7
R W B Mendes, V Pueyo, P Béguin, F J C M Duarte
BACKGROUND: This research was conducted in the Brazilian granite mining sector. After epidemiological studies, it was established that professional pneumoconiosis is related to the inhalation of dust. Therefore, the Brazilian mining health and safety regulatory standard made it compulsory to provide humidification throughout the extraction and mineral treatment processes. OBJECTIVE: To develop the concept of systemic appropriation of the technological innovations that aim to protect the worker's health...
June 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28614935/-clinical-observation-of-external-diaphragm-pacing-in-patients-with-pneumoconiosis-complicated-with-chronic-obstructive-pulmonary-disease-in-stable-stage
#8
P Jiang, X C Liu, L L Ma
No abstract text is available yet for this article.
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28598937/increasing-severity-of-pneumoconiosis-among-younger-former-us-coal-miners-working-exclusively-under-modern-dust-control-regulations
#9
Judith M Graber, Gerald Harris, Kirsten S Almberg, Cecile S Rose, Edward L Petsonk, Robert A Cohen
BACKGROUND: Coal workers' pneumoconiosis (CWP) steadily declined among US miners following dust control regulations in 1970. In 2000, severe forms of this disease reemerged among young miners, and are well described among working-but not former-miners. METHODS: Black lung benefits program (BLBP) data (2001 to 2013) were used to estimate respiratory disease burden among former miners including: (1) CWP (simple; advanced CWP, and progressive massive fibrosis [CWP/PMF]); and (2) respiratory impairment (FEV1 percent reference: mild, moderate, ≥moderately-severe)...
June 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28514304/diagnostic-and-clinical-application-value-of-magnetic-resonance-imaging-mri-for-progressive-massive-fibrosis-of-coal-worker-pneumoconiosis-case-reports
#10
Lansheng Zhang, Chun Wang, Qiuyue Yan, Tao Zhang, Zhengxiang Han, Guan Jiang
RATIONALE: Using magnetic resonance imaging (MRI), we diagnosed pneumoconiosis by identifying the content and distribution of hydrogen protons in the water molecules in different tissues and lesions. PATIENT CONCERNS: 25 cases of CWP patients with progressive massive fibrosis (PMF) lesions. DIAGNOSES: Patients were correctly diagnosed, with one case each of Phase I and II pneumoconiosis and 23 cases of Phase III pneumoconiosis. INTERVENTIONS: None...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28497853/respiratory-morbidity-among-u-s-coal-miners-in-states-outside-of-central-appalachia
#11
Laura E Reynolds, David J Blackley, Anthony S Laney, Cara N Halldin
BACKGROUND: Recent NIOSH publications have focused on the respiratory health of coal miners in central Appalachia, yet 57% of U.S. coal miners work in other regions. We characterized respiratory morbidity in coal miners from these regions. METHODS: Active coal miners working outside of central Appalachia who received chest radiographs and/or spirometry during 2005-2015 were included. Chest radiographs were classified according to International Labour Office standards and spirometry was interpreted using the American Thoracic Society guidelines...
May 12, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28481235/survival-analysis-of-coal-workers-pneumoconiosis-cwp-patients-in-a-state-owned-mine-in-the-east-of-china-from-1963-to-2014
#12
Lei Han, Qianqian Gao, Jingjin Yang, Qiuyun Wu, Baoli Zhu, Hengdong Zhang, Bangmei Ding, Chunhui Ni
To investigate the mortality probability, life expectancy of coal workers' pneumoconiosis (CWP), and related factors of life expectancy, a total of 495 patients with CWP were diagnosed and reported from 1963 to 2014 in a state-owned mine in the east of China. The life table method, log rank method, and Cox regression model were used for survival analysis. 95 out of 495 CWP died during this period. The mortality rate was 19.19%. The average life span was 12.1 (0.0-33.2) years and average death age was 57.4 (33...
May 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28444932/the-association-of-lamb1-polymorphism-and-expression-changes-with-the-risk-of-coal-workers-pneumoconiosis
#13
Xiaoming Ji, Baiqun Wu, Ruhui Han, Jingjin Yang, Esther Ayaaba, Ting Wang, Lei Han, Chunhui Ni
BACKGROUND: Pneumoconiosis is a serious occupational disease worldwide, which is characterized by irreversible and diffuse lung fibrotic lesions. Laminin beta 1(LAMB1) is widely expressed in tissues and it is crucial for both lung morphogenesis and physiological function. In this study, we explored the association between LAMB1 rs4320486 and risk of pneumoconiosis in a Chinese population, as well as its mechanisms. METHODS: In this case-control study, 600 CWP patients and 605 controls were genotyped for the LAMB1 rs4320486 polymorphism using TaqMan methods...
April 26, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28442577/association-between-exposure-in-the-cement-production-industry-and-non-malignant-respiratory-effects-a-systematic-review
#14
Anne Kristin Møller Fell, Karl Christian Nordby
OBJECTIVES: Based on findings from a systematic literature search, we present and discuss the evidence for an association between exposure to cement dust and non-malignant respiratory effects in cement production workers. DESIGN AND SETTING: Systematic literature searches (MEDLINE and Embase) were performed. Outcomes were restricted to respiratory symptoms, lung function indices, asthma, chronic bronchitis, chronic obstructive pulmonary disease, pneumoconiosis, induced sputum or fraction of exhaled nitric oxide (FeNO) measurements...
April 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28430556/pneumoconioses-radiographs-in-a-large-population-of-u-s-coal-workers-variability-in-a-reader-and-b-reader-classifications-by-using-the-international-labour-office-classification
#15
Cara N Halldin, David J Blackley, Edward L Petsonk, A Scott Laney
Purpose To assess the level of concordance between chest radiographic classifications of A and B Readers in a national surveillance program offered to U.S. coal miners over an approximate 36-year period. Materials and Methods The National Institute for Occupational Safety and Health (NIOSH) Coal Workers' Health Surveillance Program (CWHSP) is a surveillance program with nonresearch designation and is exempt from Human Subjects Review Board approval (11-DRDS-NR03). Thirty-six years of data (1979-2015) from the CWHSP were analyzed, which included all conventional screen-film radiographs with a classification by at least one A Reader and one B Reader...
April 21, 2017: Radiology
https://www.readbyqxmd.com/read/28408654/radiographic-disease-progression-in-contemporary-us-coal-miners-with-progressive-massive-fibrosis
#16
A Scott Laney, David John Blackley, Cara N Halldin
INTRODUCTION: Among contemporary US coal miners, there has been an increase in the prevalence and severity of pneumoconiosis, including its advanced form progressive massive fibrosis (PMF). We examine radiographic progression in Coal Workers' Health Surveillance Program (CWHSP) participants. METHODS: CWHSP participants with a final determination of PMF during 1 January 2000-1 October 2016 with at least one prior radiograph in the system were included. We characterised demographics, participation and progression patterns...
April 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28393722/positive-fdg-pet-ct-findings-in-a-patient-with-pneumoconiosis
#17
Tomohiro Tamura, Gen Ohara, Katsunori Kagohashi, Hiroaki Satoh
No abstract text is available yet for this article.
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28393716/pneumoconiosis-in-different-sectors-and-their-differences-in-turkey
#18
Nur Şafak Alıcı, Arif Çımrın, Ayşe Coşkun Beyan
Introduction: Pneumoconiosis which is one of the ancient diseases, still affects many workers throughout the world despite "existing" control programs. We add data from a single center reviewing risk factors for pneumoconiosis; evaluate functional and radiological findings in different sectors. Materials and Methods: We reviewed medical records of patients diagnosed with pneumoconiosis who were admitted to our center between the years 2013 and 2015. Several personal and occupational features, together with functional and radiologic data, were collected...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28370783/coal-mine-dust-lung-disease-in-the-modern-era
#19
REVIEW
Jennifer L Perret, Brian Plush, Philippe Lachapelle, Timothy S C Hinks, Clare Walter, Philip Clarke, Louis Irving, Pat Brady, Shyamali C Dharmage, Alastair Stewart
Coal workers' pneumoconiosis (CWP), as part of the spectrum of coal mine dust lung disease (CMDLD), is a preventable but incurable lung disease that can be complicated by respiratory failure and death. Recent increases in coal production from the financial incentive of economic growth lead to higher respirable coal and quartz dust levels, often associated with mechanization of longwall coal mining. In Australia, the observed increase in the number of new CWP diagnoses since the year 2000 has necessitated a review of recommended respirable dust exposure limits, where exposure limits and monitoring protocols should ideally be standardized...
May 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28366148/-positive-fdg-pet-ct-findings-in-a-patient-with-pneumoconiosis
#20
Tomohiro Tamura, Gen Ohara, Katsunori Kagohashi, Hiroaki Satoh
No abstract text is available yet for this article.
December 2016: Tüberküloz Ve Toraks
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