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https://www.readbyqxmd.com/read/29453299/pulmonary-sarcoidosis-with-and-without-extrapulmonary-involvement-a-cross-sectional-and-observational-study-in-china
#1
Cheng-Wei Li, Ru-Jia Tao, Dan-Feng Zou, Man-Hui Li, Xin Xu, Wei-Jun Cao
OBJECTIVES: Sarcoidosis is a multisystem disease characterised by the formation of granulomas within various organs, mainly the lungs. Several studies from different countries have been undertaken to investigate sarcoidosis with extrapulmonary involvement except from China. The objective of this study is to investigate a comparative clinical analysis in patients with pulmonary sarcoidosis with and without extrapulmonary involvement from China. METHODS: Data from inpatients diagnosed with sarcoidosis at Shanghai Pulmonary Hospital (Shanghai, China) between January 2009 and December 2014 were retrospectively collected and analysed...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29449808/suppressive-effects-of-clerodendrum-volubile-p-beauv-labiatae-methanolic-extract-and-its-fractions-on-type-2-diabetes-and-its-complications
#2
Ochuko L Erukainure, Rahman M Hafizur, Nurul Kabir, M Iqbal Choudhary, Olubunmi Atolani, Priyanka Banerjee, Robert Preissner, Chika I Chukwuma, Aliyu Muhammad, Eric O Amonsou, Md Shahidul Islam
Type 2 diabetes is the most prominent of all diabetes types, contributing to global morbidity and mortality. Availability and cost of treatment with little or no side effect especially in developing countries, remains a huge burden. This has led to the search of affordable alternative therapies especially from medicinal plants. In this study, the antidiabetic effect of the methanolic extract, dichloromethane (DCM), butanol (BuOH) and aqueous fractions of Clerodendrum volubile leaves were investigated in type 2 diabetic rats for their effect on glucose homeostasis, serum insulin level and hepatic biomarkers, lipid profile, pancreatic redox balance and Ca 2+ levels, and β-cell distribution and function...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29446229/biogeographical-distribution-of-bacterial-communities-in-changbai-mountain-northeast-china
#3
Dongxue Han, Ning Wang, Xue Sun, Yanbo Hu, Fujuan Feng
The broad-leaved and Korean pine mixed forest in Changbai Mountain, China is an important component of boreal forest; the area is sensitive to global climate change. To understand spatial distribution patterns of soil bacterial community along elevation, we analyzed the soil bacterial community diversity and composition along an elevational gradient of 699-1177 m in a primitive Korean pine forest in Changbai Mountain using the high-throughput sequencing. In total, 149,519 optimized sequences were obtained. Bacterial Shannon index increased along elevation from 699 m to 937 m and started to decrease at the elevation of 1,044 m, showing a humpback curve along elevation...
February 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29445360/the-dynamic-distribution-of-small-tail-han-sheep-microbiota-across-different-intestinal-segments
#4
Hao Zhang, Mingxu Shao, He Huang, Shujuan Wang, Lili Ma, Huining Wang, Liping Hu, Kai Wei, Ruiliang Zhu
The sheep intestinal tract is characterized by a diverse microbial ecosystem that is vital for the host to digest diet material. The importance of gut microbiota (GM) of animals has also been widely acknowledged because of its pivotal roles in the health and well-being of animals. However, there are no relevant studies on GM of small-tail Han sheep, a superior mutton variety domestic in China. In this study, the structure and distribution of gut microflora were studied by high-throughput sequencing technology...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29435808/moringa-oleifera-supplemented-diet-modulates-nootropic-related-biomolecules-in-the-brain-of-stz-induced-diabetic-rats-treated-with-acarbose
#5
Ganiyu Oboh, Sunday I Oyeleye, Omoyemi A Akintemi, Tosin A Olasehinde
There are strong correlations between diabetes mellitus and cognitive dysfunction. This study sought to investigate the modulatory effects of Moringa oleifera leaf (ML) and seed (MS) inclusive diets on biomolecules [acetylcholinesterase (AChE), butyrylcholinesterase (BChE)] angiotensin-I converting enzyme (ACE), arginase, catalase, glutathione transferase (GST) and glutathione peroxidase (GSH-Px) activities, glutathione (GSH) and nitric oxide (NO) levels] associated with cognitive function in the brain of streptozotocin (STZ)-induced diabetic rats treated with acarbose (ACA)...
February 12, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29434464/arm-cycling-combined-with-passive-leg-cycling-enhances-vo2peak-in-persons-with-spinal-cord-injury-above-the-sixth-thoracic-vertebra
#6
Tom Tørhaug, Berit Brurok, Jan Hoff, Jan Helgerud, Gunnar Leivseth
Objective: To test whether passive leg cycling (PLC) during arm cycling ergometry (ACE) affects peak oxygen uptake (VO2peak) differently in individuals with spinal cord injury (SCI) at/above the 6th thoracic vertebra (T6) and below T6. Methods: We conducted a cross-sectional study, analyzed by univariate and multivariate regression models. Between- and within-group differences were examined during (a) ACE only, (b) ACE combined with PLC (ACE-PLC), and (c) ACE combined with functional electrical stimulation cycling (FES hybrid)...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29433578/resistant-hypertension-on-treatment-reshypot-sequential-nephron-blockade-compared-to-dual-blockade-of-the-renin-angiotensin-aldosterone-system-plus-bisoprolol-in-the-treatment-of-resistant-arterial-hypertension-study-protocol-for-a-randomized-controlled-trial
#7
Elizabeth do Espirito Santo Cestário, Letícia Aparecida Barufi Fernandes, Luiz Tadeu Giollo-Júnior, Jéssica Rodrigues Roma Uyemura, Camila Suemi Sato Matarucco, Manoel Idelfonso Paz Landim, Luciana Neves Cosenso-Martin, Lúcia Helena Bonalume Tácito, Heitor Moreno, José Fernando Vilela-Martin, Juan Carlos Yugar-Toledo
BACKGROUND: Resistant hypertension is characterized when the blood pressure (BP) remains above the recommended goal after taking three antihypertensive drugs with synergistic actions at their maximum recommended tolerated doses, preferably including a diuretic. Identifying the contribution of intravascular volume and serum renin in maintaining BP levels could help tailor more effective hypertension treatment, whether acting on the control of intravascular volume or sodium balance, or acting on the effects of the renin-angiotensin-aldosterone system (RAAS) on the kidney...
February 12, 2018: Trials
https://www.readbyqxmd.com/read/29431859/adverse-childhood-experiences-and-depressive-symptomatology-among-pregnant-women
#8
Katja Ångerud, Eva-Maria Annerbäck, Tanja Tydén, Santosh Boddeti, Per Kristiansson
INTRODUCTION: Adverse childhood experiences (ACE) result in somatic and mental health disturbances. Its influence on antenatal depression is scarcely studied. This study examined the association between experience of ACE and antenatal depressive symptomatology. MATERIAL AND METHODS: 1257 women from 172 antenatal clinics in Sweden were surveyed during pregnancy and one year after delivery. Demographics, previous medical history and Edinburgh Postpartum Depression Scale (EPDS) were collected in pregnancy and postpartum and ACE one year postpartum...
February 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29425464/renin-angiotensin-system-inhibition-ameliorates-ccl4-induced-liver-fibrosis-in-mice-through-the-inactivation-of-nuclear-transcription-factor-kappa-b
#9
Sameh Saber, Amr A A Mahmoud, Noha Said Helal, Eman El-Ahwany, Rasha Abdelghany
Therapeutic interventions for liver fibrosis are still limited due to the complicated molecular pathogenesis. Renin-angiotensin system (RAS) seems to contribute to the development of hepatic fibrosis. Therefore, we aimed to examine the effect of RAS inhibition on CCl4-induced liver fibrosis. Mice were treated with silymarin (30 mg kg-1), perindopril (1 mg kg-1), fosinopril (2 mg kg-1), or losartan (10 mg kg-1). The administration RAS inhibitors improved liver histology and decreased protein expression of alpha smooth muscle actin (α-SMA) and hepatic content of hydroxyproline...
February 9, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29424910/correlations-between-blood-uric-acid-and-the-incidence-and-progression-of-type-2-diabetes-nephropathy
#10
G-X Li, X-H Jiao, X-B Cheng
OBJECTIVE: To investigate the relationships between blood uric acid (BUA) level and the incidence, progression and deterioration of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: A total of fifty patients with T2DM alone whose glycosylated hemoglobin (HbA1c) were under normal range (4-6.5%) at their admission to our hospital were randomly selected as diabetes mellitus (DM) group. Fifty patients with hyperuricemia alone were randomly selected as hyperuricemia (HUA) group...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29424195/clinical-features-and-prognostic-significance-of-splenic-involvement-in-sarcoidosis
#11
Cuneyt Tetikkurt, Halil Yanardag, Metin Pehlivan, Muammer Bilir
Sarcoidosis is a systemic disease characterized by noncasefied granulomas in various organs. Incidence of splenic disease is variable and is reported to occur in 6.7 to 77 percent of the patients. Firm data establishing the clinical features and the association of splenic involvement with prognosis in sarcoidosis is scant. The aim of our study was to investigate the clinical features and the consequence of splenic involvement on the prognostic outcome of sarcoidosis patients. We evaluated the clinical and laboratory findings in 82 sarcoidosis patients...
December 21, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29413079/yoga-to-enhance-self-efficacy-an-intervention-for-at-risk-youth
#12
Andrea N Kwasky, Mary L Serowoky
OBJECTIVE: Yoga has demonstrated effectiveness in improving self-management in a variety of disease states however little is known about the impact of yoga as a health promotion intervention for adolescent females in an urban school based environment. This pilot study was conducted to determine if yoga could improve the self-efficacy and body core tone in at-risk adolescent female participants. METHOD: A quasi-experimental design was employed, with data collection at baseline, end of program, and 1month post-program...
February 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29407880/the-protective-effect-of-resveratrol-on-vascular-aging-by-modulation-of-the-renin-angiotensin-system
#13
Eun Nim Kim, Min Young Kim, Ji Hee Lim, Yaeni Kim, Seok Joon Shin, Cheol Whee Park, Yong-Soo Kim, Yoon Sik Chang, Hye Eun Yoon, Bum Soon Choi
BACKGROUND AND AIMS: This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS: Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and the expression of AMP-activated protein kinase (AMPK), silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), and anti-oxidative enzymes was measured in thoracic aortas of 24-month-old mice...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29406916/quantitative-transcranial-sonography-in-wilson-s-disease-and-healthy-controls-cut-off-values-and-functional-correlates
#14
Gotthard G Tribl, Mateus C Trindade, Kelson James Almeida, Rosana Cardoso Alves, Daniel Ciampi de Andrade, Erich T Fonoff, Alexandre A Machado, Manoel J Teixeira, Egberto R Barbosa, Edson Bor-Seng-Shu
To compare transcranial sonography (TCS) findings in patients with predominantly neurological Wilson's disease (WD) to those from controls, and to correlate TCS data with the clinical profile of WD. Patients with WD (n=40/f=18) and healthy, matched controls (n=49/f=20) were assessed in terms of TCS, serum copper and iron parameters, and clinical scales, such as the Unified Wilson's Disease Rating Scale (UWDRS), Addenbrooke's Cognitive Examination-Revised (ACE-R), Mini Mental State Examination (MMSE), and Beck Depression Inventory...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29405856/a-multivariate-analysis-of-adverse-childhood-experiences-and-health-behaviors-and-outcomes-among-college-students
#15
Michael Windle, Regine Haardörfer, Beth Getachew, Jean Shah, Jackie Payne, Dina Pillai, Carla J Berg
OBJECTIVE: This study investigated associations between adverse childhood experiences (ACE) prior to age 18 years and multiple health behaviors (e.g., cigarette and other substance use) and outcomes (e.g., obesity, depression) for a large college sample. PARTICIPANTS: 2969 college students from seven universities in the state of Georgia were included in the analysis. METHODS: Web-based surveys were completed by students (45-60 minutes) during the spring semester, 2015...
February 6, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29405074/assessment-of-acetamiprid-induced-genotoxic-effects-in-bone-marrow-cells-of-swiss-albino-male-mice
#16
Preeti Bagri, S K Jain
Acetamiprid (ACE), a neonicotinoid insecticide, is widely used in agriculture either alone or in combination with other insecticides. A combined approach employing micronucleus test (MNT) and chromosomal aberrations (CA) assay was utilized to assess the genotoxic effects of ACE in bone marrow of Swiss albino male mice. Acetamiprid was administered i.p. daily at 4.6 and 2.3 mg/kg/day along with 3% gum acacia as negative control for 60 and 90 days and cyclophosphamide (50 mg/kg b.wt.) as positive control...
February 6, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29404759/shifts-in-renin-angiotensin-system-components-angiogenesis-and-oxidative-stress-related-protein-expression-in-the-lamina-cribrosa-region-of-streptozotocin-induced-diabetic-mice
#17
Xiaobing Qian, Leilei Lin, Yao Zong, Yongguang Yuan, Yanmin Dong, Yue Fu, Wanwen Shao, Yujie Li, Qianying Gao
PURPOSE: This study aimed to analyse shifts in renin-angiotensin system (RAS) components, angiogenesis, and oxidative stress-related protein expression in the lamina cribrosa (LC) region in streptozotocin (STZ)-induced diabetic mice. METHODS: Six months after diabetes induction, the retinal vessels of male C57BL/6 J mice were observed by colour photography, fundus fluorescein angiography (FFA), and immunofluorescent staining following incubation with CD31. Immunofluorescence for glial fibrillary acidic protein (GFAP), alpha-smooth muscle actin (α-SMA),and NG2 was also performed...
February 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29392343/-drug-induced-angioedema-focus-on-bradykinin
#18
REVIEW
B Sachs, T Meier, M M Nöthen, C Stieber, J Stingl
On a pathophysiological level, angioedema can be differentiated into histamine- and bradykinin-mediated types. The prototype drug-associated, bradykinin-mediated form of angioedema is angiotensin-converting enzyme (ACE) inhibitor-induced angioedema. The hypothesized cause is a decrease in bradykinin degradation via ACE inhibition. In this scenario, other bradykinin-degrading enzymes assume major importance. When the effect of these enzymes is also diminished, e. g., due to genetic variants or external factors, compensation for the inhibition of ACE may be insufficient...
February 1, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29390444/family-history-and-renin-angiotensin-system-gene-polymorphisms-in-chinese-patients-with-type-2-diabetes-mellitus
#19
Yan-Hong Pan, Yan-Mei Huang, Yong-Chao Qiao, Wei Ling, Li-Jun Geng, Jian-Long Xiao, Xiao-Xi Zhang, Hai-Lu Zhao
A positive family history is recognized as an important risk factor for type 2 diabetes mellitus (T2DM), but the association of family history with rennin-angiotensin system (RAS) gene polymorphisms has not been reported yet, thus we aim to investigate it.Family history records, clinical and biochemical data were obtained from 1239 T2DM patients. Polymerase chain reaction (PCR) was performed for angiotensin-converting enzyme (ACE) genotyping and PCR-restricted fragment length polymorphism was used for angiotensinogen (AGT) genotyping...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384421/relation-of-serum-levels-of-homocysteine-vitamin-b12-and-folate-to-cognitive-functions-in-multiple-sclerosis-patients
#20
Ebtesam Mohamed Fahmy, Nervana Mohamed Elfayoumy, Ahmed Mohamed Abdelalim, Sahar Abdel-Aaty Sharaf, Rania Shehata Ismail, Haidy Elshebawy
BACKGROUND: Hyperhomocysteinemia, vitamin B12 and folate deficiency have been linked to cognitive dysfunction in multiple sclerosis (MS) patients. OBJECTIVE: This study aimed to investigate the relation of serum homocysteine (Hcy), vitamin B12 and folate to cognitive functions in MS patients. SUBJECTS AND METHODS: Forty-five MS patients and twenty matched healthy controls were included. Subjects were submitted to cognitive assessment using a selected psychometric battery and measurement of serum levels of homocysteine, B12 and folic acid...
January 31, 2018: International Journal of Neuroscience
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