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https://www.readbyqxmd.com/read/28822808/bml-111-equilibrated-ace-angii-at1r-and-ace2-ang-1-7-mas-axis-to-protect-hepatic-fibrosis-in-rats
#1
Quandong Hu, Zhenzhen Hu, Qiongfeng Chen, Yonghong Huang, Zi Mao, Fangyun Xu, Xiaoyan Zhou
BACKGROUND: It was recently reported Lipoxins (LXs) had protective effects on fibrous diseases, and renin-angiotensin-aldosterone system (RAAS) had played vital and bidirectional roles in hepatic fibrosis. In this paper, a hepatic fibrosis model, induced by carbon tetrachloride (CCL4) in rats, was used to observe the relations between RAAS and LXs, as well as to further explore the alternative anti-fibrosis mechanisms of LXs. METHODS: The model was evaluated by morphological observations and biochemical assays...
August 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28820397/long-term-feeding-with-bioactive-tripeptides-in-aged-hypertensive-and-normotensive-rats-special-focus-on-blood-pressure-and-bradykinin-induced-vascular-reactivity
#2
A Siltari, J Roivanen, R Korpela, H Vapaatalo
Bradykinin is the main player of the kallikrein-kinin system. Bradykinin-induced vasodilatation is age-dependent; this is believed to be associated with the level of expression of the two bradykinin receptors (BR1 and BR2) in the vasculature. The aim of this study was to clarify bradykinin-induced vascular reactivity of spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto rats (WKY) after 6 weeks' consumption of a drink containing bioactive tripeptides (Ile-Pro-Pro, Val-Pro-Pro and Leu-Pro-Pro)...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28820392/orally-administered-angiotensin-converting-enzyme-inhibitors-captopril-and-isoleucine-proline-proline-have-distinct-effects-on-local-renin-angiotensin-system-and-corticosterone-synthesis-in-dextran-sulfate-sodium-induced-colitis-in-mice
#3
H Salmenkari, M Holappa, R A Forsgard, R Korpela, H Vapaatalo
The effects of angiotensin-converting enzyme (ACE) inhibition by an antihypertensive drug, captopril, and milk casein-derived ACE-inhibiting bioactive tripeptide isoleucine-proline-proline (Ile-Pro-Pro), on local renin-angiotensin system (RAS) and glucocorticoid production in the intestine were studied in the dextran sodium sulfate induced colitis in mice. Mice received water or 3% dextran sodium sulfate with or without either 15.7 mg/l captopril or 833 mg/l Ile-Pro-Pro for 7 days. Captopril and Ile-Pro-Pro were found to have distinct effects on local renin-angiotensin system and mRNA expression of glucocorticoid synthesis components in colon in vitro...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28797632/association-of-angiotensin-ii-levels-with-albuminuria-in-subjects-with-normal-glucose-metabolism-prediabetes-and-type-2-diabetes-mellitus
#4
Se Hee Min, Sung Hye Kong, Jie-Eun Lee, Dong-Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Kyong Soo Park, Hak Chul Jang, Soo Lim
OBJECTIVES: The relationship between the renin-angiotensin system (RAS) and diabetes has been studied for many years. However, studies that assessed RAS components comprehensively were limited. We hypothesized that serum RAS components, especially the effector peptide angiotensin-II, might be closely associated with glucose metabolism status and diabetic complications. METHODS: We investigated the association of individual RAS component with albuminuria in 407 subjects with normal glucose metabolism (NGM), prediabetes, or type 2 diabetes mellitus (T2DM)...
July 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28796769/medication-related-patient-harm-in-new-zealand-hospitals
#5
MULTICENTER STUDY
Gillian Robb, Elizabeth Loe, Ashika Maharaj, Richard Hamblin, Mary E Seddon
AIM: The purpose of this study is to identify patterns of medication-related harm from a national perspective, and to use this information to inform decisions on where to focus medication safety efforts. This study updates a 2013 study using the same methodology. METHOD: District health boards (DHBs) still actively using either the Adverse Drug Event (ADE) Trigger Tool (TT) or the Global Trigger Tool (GTT), submitted two years of anonymised ADE data (1 July 2013-30 June 2015) to the Health Quality & Safety Commission (the Commission) using a standard template...
August 11, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28789938/azilsartan-ameliorates-diabetic-cardiomyopathy-in-young-db-db-mice-through-the-modulation-of-ace-2-ang-1-7-mas-receptor-cascade
#6
Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Eisuke Tatsumi, Mikiyasu Shirai, James T Pearson
Hyperglycemia up-regulates intracellular angiotensin II (ANG-II) production in cardiac myocytes. This study investigated the hemodynamic and metabolic effects of azilsartan (AZL) treatment in a mouse model of diabetic cardiomyopathy and whether the cardioprotective effects of AZL are mediated by the angiotensin converting enzyme (ACE)-2/ANG 1-7/Mas receptor (R) cascade. Control db/+ and db/db mice (n=5 per group) were treated with vehicle or AZL (1 or 3mg/kg/d oral gavage) from the age of 8 to 16weeks. Echocardiography was then performed and myocardial protein levels of ACE-2, Mas R, AT1R, AT2R, osteopontin, connective tissue growth factor (CTGF), atrial natriuretic peptide (ANP) and nitrotyrosine were measured by Western blotting...
August 5, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28780164/changes-in-epigenetic-markers-dnmt1-and-hdac1-2-in-the-adult-mouse-hippocampus-after-cranial-irradiation
#7
Sohi Kang, Yeonghoon Son, Sueun Lee, Juhwan Kim, Jong-Choon Kim, Joong-Sun Kim, Uhee Jung, Sung-Ho Kim, Miyoung Yang, Changjong Moon
Brain exposure to ionizing radiation can cause functional deficits in the hippocampus, including memory impairment. However, the specific molecular mechanisms underlying irradiation-induced cognitive impairments are largely unknown. Changes in DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), which are involved in DNA methylation and histone remodeling, may be associated with behavioral changes in learning and memory. We assessed changes in the levels of enzymes associated with the epigenetic modification of gene expression, including DNMT1, HDAC1, HDAC2, Sirtuin 1 (SIRT1), and acetylated histone H3 (Ace-H3) in the mouse hippocampus 1 and 30days after a single exposure to cranial irradiation (0 or 10Gy)...
August 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28771512/ace-phenotyping-in-human-heart
#8
Victoria E Tikhomirova, Olga A Kost, Olga V Kryukova, Elena Z Golukhova, Naida I Bulaeva, Aigerim Z Zholbaeva, Leo A Bokeria, Joe G N Garcia, Sergei M Danilov
AIMS: Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, is expressed as a type-1 membrane glycoprotein on the surface of different cells, including endothelial cells of the heart. We hypothesized that the local conformation and, therefore, the properties of heart ACE could differ from lung ACE due to different microenvironment in these organs. METHODS AND RESULTS: We performed ACE phenotyping (ACE levels, conformation and kinetic characteristics) in the human heart and compared it with that in the lung...
2017: PloS One
https://www.readbyqxmd.com/read/28765966/aliskiren-has-chondroprotective-efficacy-in-a-rat-model-of-osteoarthritis-through-suppression-of-the-local-renin-angiotensin-system
#9
Kaizhong Yan, Yixin Shen
The local renin-angiotensin system (RAS) has been reported to have an important role in the pathogenesis and progression of metabolic bone diseases, including osteoarthritis (OA). Aliskiren is the first in a new class of orally effective direct renin inhibitors and is approved for the treatment of hypertension in humans. However, its efficacy in patients with OA is unknown. A rat model of OA was induced to investigate the potential efficacy of aliskiren. Effects of aliskiren on the cartilage structure were detected by safranin O staining and its effects on the widths of the proliferation zone and hypertrophic zone (HZ) of chondrocytes were analyzed by Masson's staining...
July 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28762934/-diagnostic-value-of-biochemical-markers-in-patients-with-chronic-heart-failure-with-reduced-borderline-and-preserved-left-ventricular-ejection-fraction
#10
E V Bazaeva, R P Myasnikov, V A Metelskaya, S A Boytsov
PURPOSE OF THE STUDY: The study of the diagnostic value of biochemical markers of myocardial stress and inflammation in chronic heart failure (CHF) with different values of the ejection fraction (EF) of the left ventricle (LV). MATERIAL AND METHODS: The cross-sectional study included 105 patients aged 24 to 84 years (mean 58+/-14 years) with stable chronic heart failure I-II NYHA functional class classification. The causes of CHF were ischemic heart disease (IHD) in 33% of patients and arterial hypertension (AH) - 67%...
March 2017: Kardiologiia
https://www.readbyqxmd.com/read/28758770/adverse-childhood-experiences-and-obesity-systematic-review-of-behavioral-interventions-for-women
#11
Cheryl J McDonnell, Samantha V Garbers
OBJECTIVE: Studies have demonstrated a relationship between adverse childhood experiences (ACEs) and adult obesity. Group interventions addressing the psychosocial sequelae of ACES using a trauma-informed approach for adults are well described in the literature. There is also a significant body of literature on the efficacy and proposed structure of interventions addressing weight reduction in adults. However, it is unknown how often interventions addressing attainment of a healthy weight incorporate a specific focus on adult women with a history of ACEs, including childhood abuse and trauma...
July 31, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28758596/effects-of-sleeve-gastrectomy-on-the-metabolic-profile-and-on-the-expression-of-renin-angiotensin-system-in-adipose-tissue-of-obese-rats
#12
Thaísa Soares Crespo, João Marcus Oliveira Andrade, Alanna Fernandes Paraíso, Deborah de Farias Lelis, Pablo Vinicyus Ferreira Chagas, Antônio Sérgio Barcala Jorge, Wagner Leite Ferreira, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Sérgio Henrique Sousa Santos
Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity. The present study assessed the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. Male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated...
July 28, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28758594/effects-of-resveratrol-and-ace-inhibitor-enalapril-on-glucose-and-lipid-profiles-in-mice
#13
Thaisa de Almeida Pinheiro, Thales de Almeida Pinheiro, Jonh David Feltenberger, João Marcus Oliveira Andrade, Emillio César Ferreira, Deborah De Farias Lelis, Andre Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Antônio Prates Caldeira, Sergio Sousa Santos
Lipogenesis is a process that involves the synthesis of fatty acids. Resveratrol and enalapril are being studied for their beneficial physiological properties on the glucose and lipid metabolism. The aim of the present study was to evaluate the oral administration of resveratrol and enalapril on the glucose and lipid metabolism, evaluating the white pad lipogenesis genes expression in mice. Swiss male mice were divided into four groups and treated for eight weeks as follows: Standard diet ad libitum (G1); Standard diet + Resveratrol (G2); Standard diet + Enalapril (G3); Standard diet + Resveratrol + Enalapril (G4), where resveratrol was administered with the food and enalapril with the water...
July 28, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28755550/impact-of-early-life-adversity-and-tryptophan-depletion-on-functional-connectivity-in-menopausal-women-a-double-blind-placebo-controlled-crossover-study
#14
Sheila Shanmugan, Theodore D Satterthwaite, Mary D Sammel, Wen Cao, Kosha Ruparel, Ruben C Gur, C Neill Epperson, James Loughead
During the menopause transition, women are at increased risk of subjective symptoms of executive dysfunction. Evidence from animal and human participant studies suggests adverse childhood experiences (ACE) may be a risk factor for executive complaints during this hormonal transition. Preclinical literature indicates early life adversity effects on serotonin function may play a role in this increased susceptibility. However, the mechanisms underlying this increase in vulnerability in human participants remain relatively unknown...
July 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28750134/performance-evaluation-of-a-collapsed-cone-dose-calculation-algorithm-for-hdr-ir-192-of-apbi-treatments
#15
Dario Terribilini, Veronika Vitzthum, Werner Volken, Daniel Frei, Kristina Loessl, Bob van Veelen, Peter Manser, Michael K Fix
PURPOSE: Most dose calculations for HDR brachytherapy treatments are based on the AAPM-TG43 formalism. Because patient's anatomy, heterogeneities and applicator shielding are not considered, the dose calculation based on this formalism is inaccurate in some cases. Alternatively, Collapsed Cone (CC) methods as well as Monte Carlo (MC) algorithms belong to the model based dose calculation algorithms, which are expected to improve the accuracy of calculated dose distributions. In this work, the performance of a CC algorithm, ACE in Oncentra Brachy 4...
July 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/28748695/extraction-and-quantification-of-sinapinic-acid-from-irish-rapeseed-meal-and-assessment-of-angiotensin-i-converting-enzyme-ace-i-inhibitory-activity
#16
Leah Quinn, Steven G Gray, Steve Meaney, Stephen Finn, Padraig McLoughlin, Maria Hayes
Phenolic compounds, including phenolic acids, are known to play a protective role against the development of cardiovascular disease. The aim of this work was to generate a phenolic acid extract from Irish rapeseed meal, to determine the quantity of sinapinic acid (SA) in this fraction and to assess the ability of this fraction to inhibit the enzyme angiotensin-I converting enzyme (ACE-I; EC 3.4.15.1). A crude phenolic extract (fraction 1), free phenolic acid containing extract (fraction 2), and an extract containing phenolic acids liberated from esters (fraction 3) were generated from Irish rapeseed meal using a methanol:acetone:water solvent mixture (7:7:6)...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28746343/an-analysis-of-retrospective-and-repeat-prospective-reports-of-adverse-childhood-experiences-from-the-south-african-birth-to-twenty-plus-cohort
#17
Sara N Naicker, Shane A Norris, Musawenkosi Mabaso, Linda M Richter
Most studies rely on cross-sectional retrospective reports from adult samples to collect information about adverse childhood experiences (ACEs) to examine relationships with adult outcomes. The problems associated with these reports have long been debated, with only a few studies determining their reliability and validity and fewer still reaching consensus on the matter. This paper uses repeat prospective and retrospective reports of adverse childhood experiences from two respondent sources in the South African Birth to Twenty Plus (Bt20+) cohort to explore agreement and concordance in the prospective reporting of ACEs by caregivers and respective children as adolescents and then as young adults...
2017: PloS One
https://www.readbyqxmd.com/read/28744992/the-effect-of-12-weeks-carnosine-supplementation-on-renal-functional-integrity-and-oxidative-stress-in-pediatric-patients-with-diabetic-nephropathy-a-randomized-placebo-controlled-trial
#18
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Abdel Rahman El-Naggar, Mahitab Hany Hamouda, Manal El-Hamamsy
BACKGROUND AND OBJECTIVES: Oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. Carnosine is a natural radical oxygen species scavenger. We investigated the effect of carnosine as an adjuvant therapy on urinary albumin excretion (UAE), the tubular damage marker alpha 1-microglobulin (A1M), and oxidative stress in pediatric patients with type 1 diabetes and nephropathy. METHODS: This randomized placebo-controlled trial included 90 patients with diabetic nephropathy, despite oral angiotensin-converting enzyme inhibitors (ACE-Is), who were randomly assigned to receive either 12 weeks of carnosine 1 g/day (n = 45), or matching placebo (n = 45)...
July 26, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28733880/effect-of-asiatic-acid-on-the-ang-ii-at1r-nadph-oxidase-nf-%C3%AE%C2%BAb-pathway-in-renovascular-hypertensive-rats
#19
Putcharawipa Maneesai, Sarawoot Bunbupha, Upa Kukongviriyapan, Laddawan Senggunprai, Veerapol Kukongviriyapan, Parichat Prachaney, Poungrat Pakdeechote
Asiatic acid, a triterpenoid compound derived from Centella asiatica, has been demonstrated to have antioxidant and anti-inflammatory effects. The present study evaluated the effects of asiatic acid on hemodynamic alterations, renin-angiotensin system (RAS), oxidative stress, and inflammation in 2K-1C hypertensive rats. Renovascular hypertension was induced in male Sprague-Dawley rats and treated with vehicle, asiatic acid (30 mg/kg/day), or captopril (5 mg/kg/day) for 4 weeks. We observed that 2K-1C hypertensive rats exhibited hemodynamic alterations such as high blood pressure, heart rate, hindlimb vascular resistance, and low hindlimb blood flow...
July 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28731534/internal-quality-control-in-an-academic-cytopathology-laboratory-for-the-introduction-of-a-new-reporting-system-for-endometrial-cytology
#20
Niki Margari, Abraham Pouliakis, Dionysios Aninos, Christos Meristoudis, Magdalini Stamataki, Ioannis Panayiotides, Petros Karakitsos
BACKGROUND: To evaluate reproducibility of a reporting system for endometrial cytology. METHODS: Cytologic slides from 49 patients, prepared via liquid based cytology, were blindly examined by five cytopathologists of various experience levels, applying a recently introduced reporting system as previously reported. The agreement among cytopathologists was evaluated via Kappa (κ) statistics and the Kendall's Coefficient of Variation (W); cytologic results were compared with the relevant histologic report...
July 21, 2017: Diagnostic Cytopathology
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