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https://www.readbyqxmd.com/read/29676873/-bradykinin-and-cardiovascular-protection-role-of-perindopril-an-inhibitor-of-angiotensin-conversion-enzyme
#1
P Lancellotti, A Ancion, V D'Orio, O Gach, P Maréchal, J M Krzesinski
The endothelium plays a vital role as part of the cardiovascular continuum. Risk factors such as hypertension and dyslipidemia unbalance angiotensin II - bradykinin homeostasis, leading to endothelial dysfunction and changes in vascular structure that promote atherosclerosis and thrombosis. When dealing with risk factors, treatment should focus on the prevention and restoration of endothelial function. Not all cardiovascular drugs are able to reverse vascular and structural endothelial dysfunction. Increasing levels of bradykinin is an effect of the use of angiotensin-converting enzyme inhibitors (ACE-Is), and also a fundamental part of their mode of action...
April 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29673745/-acquired-c1-esterase-inhibitor-deficiency-via-bradykinin-mediated-angioedema-four-cases
#2
C Jacquin-Porretaz, F Castelain, E Daguindau, E Seilles, C Nardin, F Aubin, F Pelletier
BACKGROUND: Acquired C1-esterase inhibitor (C1-INH) deficiency angioedema (C1-INH-AAE) is a form of bradykinin-mediated angioedema. This rare disorder is due to acquired consumption of C1-INH, hyperactivation of the classic pathway of human complement, and potentially fatal recurrent angioedema symptoms. Clinical symptoms of C1-INH-AAE are very similar to those of hereditary angioedema (HAE) but usually appear after the fourth decade of life and induce abdominal pain less frequently. Laboratory tests are essential in establishing the diagnosis with low levels or abnormal structure and function of C1-INH...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29673592/intravenous-vitamin-c-attenuates-hemorrhagic-shock-related-renal-injury-through-the-induction-of-sirt1-in-rats
#3
Meng-Zhi Qi, Yi Yao, Rong-Li Xie, Si-Lei Sun, Wen-Wu Sun, Jin-Long Wang, Ying Chen, Bing Zhao, Er-Zhen Chen, En-Qiang Mao
To investigate the effect of intravenous Vitamin C (VC) on hemorrhagic shock (HS)-associated rat renal injury and the involved mechanism. Thirty SD rats were randomly assigned to the sham surgery (sham), hemorrhagic shock (HS), HS+100 mg/kg VC (H + VL), HS+500 mg/kg VC (H + VH) and HS+100 mg/kg VC + EX527 (H + VL + E) groups. Tissue and blood samples were collected 6 h after surgery. Kidney pathological changes were scored. Creatinine (CRE), blood urea nitrogen (BUN), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) levels in serum and Vitamin C levels and superoxide dismutase (SOD) activity and the ability to suppress hydroxyl radical (RAFHR) in plasma were measured...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29669332/paritaprevir-ritonavir-ombitasvir-plus-dasabuvir-regimen-in-the-treatment-of-genotype-1-chronic-hepatitis-c-infection-in-patients-with-severe-renal-impairment-and-end-stage-renal-disease-a-real-life-cohort
#4
Jan Sperl, Miluse Kreidlova, Dusan Merta, Klara Chmelova, Renata Senkerikova, Sona Frankova
BACKGROUND/AIMS: Chronic hepatitis C (HCV) virus infection reactivates under immunosuppressive drugs and therefore has a negative impact on long-term survival of kidney transplant recipients. Treatment-induced clearance of hepatitis C virus (HCV) in kidney transplant candidates prevents virus reactivation after transplantation. Paritaprevir/Ritonavir/Ombitasvir with Dasabuvir (PrOD) represents a highly effective treatment regimen for HCV genotype 1 (GT1), also suitable for patients with end-stage renal disease (ESRD)...
April 13, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29668736/differing-patterns-of-stress-and-craving-across-the-day-in-moderate-heavy-alcohol-consumers-during-their-typical-drinking-routine-and-an-imposed-period-of-alcohol-abstinence
#5
Rhiannon E Mayhugh, W Jack Rejeski, Meredith R Petrie, Paul J Laurienti, Lise Gauvin
BACKGROUND: Stress is a known factor related to alcohol use. However, how the relationship between alcohol craving and stress varies across the day is not fully understood. As craving is a consistent predictor of alcohol use disorder (AUD), understanding stress and craving patterns across the day in routine, non-dependent, moderate-heavy alcohol consumers may help in understanding those who may be vulnerable to transitioning into AUD. METHOD: Moderate-heavy drinkers were recruited from the local community (n = 32) and assessed for fluctuations in craving and stress intensity across the day via Ecological Momentary Assessment (EMA) during 3 consecutive days of imposed alcohol abstinence (abstained trial) and their normal drinking routine (normal trial)...
2018: PloS One
https://www.readbyqxmd.com/read/29660936/associations-of-angiotensin-converting-enzyme-1-and-angiotensin-ii-blood-levels-and-cognitive-function
#6
Sevil Yasar, Vijay R Varma, Gregory C Harris, Michelle C Carlson
BACKGROUND: Emerging evidence suggests a possible role of the renin angiotensin system in the pathophysiologic process of Alzheimer's disease, of which angiotensin converting enzyme-1 (ACE-1) and angiotensin II (ANGII) are important proteins. Few studies evaluated associations between blood ACE-1 and none between ANGII levels, and cognition. OBJECTIVE: Our pilot study was aimed to examine associations between blood ACE-1 and ANG II levels and cognitive function in non-demented participants at baseline and over a 1-year period...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29656391/proteomic-analysis-of-sperm-proteins-in-infertile-men-with-high-levels-of-reactive-oxygen-species
#7
A Ayaz, A Agarwal, R Sharma, N Kothandaraman, Z Cakar, S Sikka
Oxidative stress is a significant risk factor for male infertility. A pro-oxidant testicular environment may alter the expression profile of functional sperm proteins and result in poor sperm quality. Patients and donors were divided into ROS (-) and ROS (+) groups. Using computational studies, and data mining of available literature on spermatozoa, oxidative stress and proteomics, we identified three core regulatory proteins angiotensin-converting enzyme (ACE), heat-shock protein (Hsp70) family A member 2 (HSPA2) and ribosomal protein subunit 27A (RPS27A) and seven interlink proteins NOS2, SUMO2, UBL4A, FBXO25, MAP3K3, APP and UBC...
April 15, 2018: Andrologia
https://www.readbyqxmd.com/read/29655688/novel-ras-inhibitor-25-o-methylalisol-f-attenuates-epithelial-to-mesenchymal-transition-and-tubulo-interstitial-fibrosis-by-selectively-inhibiting-tgf-%C3%AE-mediated-smad3-phosphorylation
#8
Hua Chen, Tian Yang, Min-Chang Wang, Dan-Qian Chen, Yang Yang, Ying-Yong Zhao
BACKGROUND: Tubulo-interstitial fibrosis (TIF) is the common pathway in the chronic kidney disease (CKD). Epithelial-to-mesenchymal transition (EMT) is a major contributor to the TIF by the increased myofibroblasts. Renin-angiotensin system (RAS) is critical mediator on EMT in progressive CKD. Angiotensin II (ANG) mediates EMT and causes TIF by stimulating transforming growth factor-β1 (TGF-β1). RAS activation could further activate TGF-β1. Inhibition of the RAS is one of the most powerful therapies for progressive CKD...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652095/decrease-in-neprilysin-and-vasoconstrictors-and-increase-in-vasodilators-following-bariatric-surgery
#9
Husam Ghanim, Scott Monte, Joseph Caruana, Kelly Green, Sanaa Abuaysheh, Paresh Dandona
Since morbid obesity is associated with congestive cardiac failure and hypertension, and gastric bypass surgery is followed by a reduction in blood pressure and in the risk of congestive cardiac failure, we hypothesized that weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of renin angiotensin system (RAS), catecholamines and endothelin-1 with an increase in the concentrations of vasodilators...
April 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29629790/the-association-between-adverse-childhood-experience-ace-and-school-success-in-elementary-school-children
#10
Christopher Blodgett, Jane D Lanigan
We explored the feasibility of using school personnel as reporters to examine the relationship between the level of adverse childhood experiences (ACEs) exposure in a nonclinical sample of public elementary schoolchildren and academic risk. We selected a random sample of 2,101 children from kindergarten through 6th grade classroom rosters at 10 elementary schools. Students were 50% male, 78% White, and 55% free and reduced meal program participants. School personnel reported their factual knowledge of 10 ACEs and academic risk in a database controlled by the schools...
March 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29625325/tailoring-health-related-messages-for-young-adults-with-adverse-childhood-experiences-aces
#11
Canan Karatekin, Rohini Ahluwalia, Michelle Desir
The goal was to identify factors that might affect likelihood of seeking health-related interventions for young adults with adverse childhood experiences (ACEs). We tested whether ACEs were associated with (1) regulatory focus (tendency toward promoting good outcomes versus preventing bad outcomes), and (2) patient activation (the intention to take active charge of one's health). We further tested whether promotion and prevention and patient activation were associated with each other and with health. Students at a public university (N = 321) completed online questionnaires assessing ACEs, regulatory focus, patient activation, and health...
April 3, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29621266/intrinsic-and-extrinsic-motivators-of-attachment-under-active-inference
#12
David Cittern, Tobias Nolte, Karl Friston, Abbas Edalat
This paper addresses the formation of infant attachment types within the context of active inference: a holistic account of action, perception and learning in the brain. We show how the organised forms of attachment (secure, avoidant and ambivalent) might arise in (Bayesian) infants. Specifically, we show that these distinct forms of attachment emerge from a minimisation of free energy-over interoceptive states relating to internal stress levels-when seeking proximity to caregivers who have a varying impact on these interoceptive states...
2018: PloS One
https://www.readbyqxmd.com/read/29614743/protective-effect-of-polyphenol-rich-extract-from-bee-pollen-in-a-high-fat-diet
#13
Anna Rzepecka-Stojko, Agata Kabała-Dzik, Robert Kubina, Krzysztof Jasik, Maciej Kajor, Dorota Wrześniok, Jerzy Stojko
We have studied a preventive effect of polyphenol-rich bee pollen ethanol extract (EEP) against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57 BL₆ mice. Supplementing the diet with EEP in the doses of 0.1 g/kg body mass (BM) and 1 g/kg BM resulted in a decrease of total cholesterol by 31% and 35%, respectively...
March 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29614735/children-and-caregivers-exposure-to-adverse-childhood-experiences-aces-association-with-children-s-and-caregivers-psychological-outcomes-in-a-therapeutic-preschool-program
#14
Yair Ziv, Inbar Sofri, Kristen L Capps Umphlet, Stephanie Olarte, Jimmy Venza
Exposure to adverse childhood experiences (ACE) has been found to have a profound negative impact on multiple child outcomes, including academic achievement, social cognition patterns, and behavioral adjustment. However, these links have yet to be examined in preschool children that are already experiencing behavior or social-emotional problems. Thus, the present study examined the links between the caregiver's and the child's exposure to ACE and multiple child and caregiver's outcomes in a sample of 30 preschool children enrolled in a Therapeutic Nursery Program (TNP)...
March 31, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29594369/maternal-adverse-childhood-experiences-and-antepartum-risks-the-moderating-role-of-social-support
#15
Nicole Racine, Sheri Madigan, Andre Plamondon, Erin Hetherington, Sheila McDonald, Suzanne Tough
The aims of the current study were to examine the association between maternal adverse childhood experiences (ACEs) and antepartum health risks, and to investigate whether social support moderated this association. It was hypothesized that ACEs would be associated with antepartum health risks; however, social support in the prenatal period would buffer mothers from the deleterious consequences of ACEs. Data from 1994 women (mean age = 31 years) and their infants were collected from a longitudinal cohort recruited in health care offices in Alberta, Canada...
March 28, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29592796/c3-glomerulopathy-in-cystic-fibrosis-a-case-report
#16
Domenico Santoro, Rossella Siligato, Carmela Vadalà, Mariacristina Lucanto, Simona Cristadoro, Giovanni Conti, Michele Buemi, Stefano Costa, Ettore Sabadini, Giuseppe Magazzù
BACKGROUND: C3 glomerulonephritis is a rare glomerulopathy characterized at renal biopsy by C3 deposition, alone or with scanty immunoglobulins, as well as by an electron-dense material in mesangium, subendothelial and subepithelial space. An abnormal systemic activation of the alternative pathway of the complement cascade is responsible for the development of the disease if triggered by several possible environmental conditions. We report the first case in literature of a patient affected by cystic fibrosis and C3GN...
March 28, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29588951/magnitude-and-factors-associated-with-nonadherence-to-antiepileptic-drug-treatment-in-africa-a-cross-sectional-multisite-study
#17
Fredrick Ibinda, Peter Odermatt, Symon M Kariuki, Angelina Kakooza-Mwesige, Ryan G Wagner, Seth Owusu-Agyei, Honorati Masanja, Anthony K Ngugi, Caroline K Mbuba, Victor C K Doku, Brian G Neville, Josemir W Sander, Charles R J C Newton
Objectives: The epilepsy treatment gap is large in low- and middle-income countries, but the reasons behind nonadherence to treatment with antiepileptic drugs (AEDs) across African countries remain unclear. We investigated the extent to which AEDs are not taken and associated factors in people with active convulsive epilepsy (ACE) identified in cross-sectional studies conducted in five African countries. Methods: We approached 2,192 people with a confirmed diagnosis of ACE for consent to give blood voluntarily...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29587164/nitric-oxide-donors-for-peripheral-artery-disease
#18
REVIEW
Debbie Falconer, Nikolaos Papageorgiou, Karim Salem, Wei Yao Lim, Athanasios Katsargyris, Efthimios Avgerinos, Dimitris Tousoulis
Current management of peripheral arterial disease involves risk factor modification and revascularisation, but many patients are still left with debilitating symptoms. Therefore, new treatment strategies are needed. The importance of nitric oxide, and its role in regulating endothelial function, is well-established. Altering the nitric oxide pathway has been extensively studied as a means of treating vascular disease, including peripheral arterial disease. Statins and ACE inhibitors have been shown to enhance endogenous nitric oxide and improve intermittent claudication symptoms...
March 24, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29582789/serum-and-tissue-angiotensin-converting-enzyme-in-patients-with-alopecia-areata
#19
Shabnam Fahim, Fatemeh Montazer, Hamid Reza Tohidinik, Zahra Safaei Naraghi, Robabeh Abedini, Maryam Nasimi, Narges Ghandi
BACKGROUND: Alopecia areata is an immune-dependent disorder characterized by the interaction of T-lymphocytes with follicular antigens. Recent studies have shown the existence of a local renin-angiotensin system in the skin, where angiotensin-converting enzyme (ACE) plays a role in autoimmunity and inflammation. AIM: The objective of this study was to evaluate serum and tissue ACE activity in patients with alopecia areata. METHODS: This case-control study was conducted on patients with alopecia areata and healthy controls...
March 27, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29579986/ohmic-heating-a-potential-technology-for-sweet-whey-processing
#20
Naiara R Costa, Leandro P Cappato, Marcus Vinicius S Ferreira, Roberto P S Pires, Jeremias Moraes, Erick A Esmerino, Ramon Silva, Roberto P C Neto, Maria Inês B Tavares, Mônica Q Freitas, Raimundo N Silveira Júnior, Flávio N Rodrigues, Rodrigo C Bisaggio, Rodrigo N Cavalcanti, Renata S L Raices, Marcia C Silva, Adriano G Cruz
The use of Ohmic Heating (OH) for sweet whey processing was investigated in this study. Whey samples were subjected to both different OH parameters (2, 4, 5, 7 and 9 V·cm-1 at 60 Hz, up to 72-75 °C/15 s) and conventional processing (72-75 °C/15 s). Physicochemical analyses (pH), color measurements (L*, a*, b*), rheological properties (flow curves and particle size distribution), microstructure (optical microscopy), bioactive compounds (ACE and antioxidant capacity), microbiological characterization (mesophilic bacteria, total coliforms, and thermotolerant coliforms), water mobility (TD-magnetic resonance domain), and sensory evaluation (descriptive analysis) were carried out...
April 2018: Food Research International
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