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https://www.readbyqxmd.com/read/28525611/adverse-childhood-experiences-and-higher-level-functional-limitations-among-older-japanese-people-results-from-the-jages-study
#1
Airi Amemiya, Takeo Fujiwara, Hiroshi Murayama, Yukako Tani, Katsunori Kondo
Background.: A life-course perspective is essential in understanding the determinants of higher-level functional limitations. We examine the impact of adverse childhood experiences (ACEs) on higher-level functional limitations in older people. Methods.: Data were from the Japan Gerontological Evaluation Study 2013, a population-based cohort of independent people aged 65 years or older across Japan (n = 19,220). ACEs before the age of 18 were assessed in terms of seven adversities: parental death, parental divorce, parental mental illness, family violence, physical abuse, psychological neglect, and psychological abuse...
May 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28515501/ismp-medication-error-report-analysis-potential-issues-with-new-basal-insulin-glp-1-fixed-combinations-hydroxyzine-hydroxyurea-mix-up-concomitant-use-of-entresto-and-ace-inhibitors-can-lead-to-serious-outcomes-more-outpatient-oral-cancer-drugs-should-be-in
#2
Michael R Cohen, Judy L Smetzer
These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28514598/the-communal-relation-of-mthfr-mtr-ace-gene-polymorphisms-and-hyperhomocysteinemia-as-conceivable-risk-of-coronary-artery-disease
#3
Rizwan Masud, Haider Zaigham Baqai
Homocysteine and its modulating genes have strongly emerged as novel biomarkers for coronary artery disease (CAD). In present study, we investigated whether polymorphisms in homocysteine pathway genes and the plasma levels of homocysteine, folate and vitamin B12, independently or in combination, are associated with CAD risk. A total of 504 participants were recruited (cases n = 254, controls n = 250, respectively). Tetra primer allele refractory mutation system (ARMS) PCR was used for resolving the genotypes of 5'10' methylenetetrahydrofolate reductase 'MTHFR' polymorphisms (rs1801133, rs1801131), 5' methyl tetrahydrofolate homocysteine methyltransferase 'MTR' polymorphism (rs1805087), paroxanse1 'PON1' polymorphism (rs662), and cystathionine beta synthase 'CBS' polymorphism (rs5742905)...
May 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28511735/addenbrooke-s-cognitive-examination-revised-normative-and-accuracy-data-for-seniors-with-heterogeneous-educational-level-in-brazil
#4
Karolina G César, Mônica S Yassuda, Fabio H G Porto, Sonia M D Brucki, Ricardo Nitrini
BACKGROUND: Several cognitive tools have been developed aiming to diagnose dementia. The cognitive battery Addenbrooke's Cognitive Examination - Revised (ACE-R) has been used to detect cognitive impairment; however, there are few studies including samples with low education. The aim of the study was to provide ACE-R norms for seniors within a lower education, including illiterates. An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND)...
May 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28509376/adverse-childhood-experiences-aces-stress-and-mental-health-in-college-students
#5
Canan Karatekin
The goal of this short-term longitudinal study was to examine whether adverse childhood experiences (ACEs) could be used to identify college students at risk for mental health problems and whether current level of stress mediates the relationship between ACEs and mental health. Data on ACEs and mental health (depression, anxiety and suicidality) were collected at the beginning of the semester, and data on current stressors and mental health were collected toward the end of the semester (n = 239). Findings indicated that ACEs predicted worsening of mental health over the course of a semester and suggested current number of stressors as a mediator of the relationship between ACEs and mental health...
May 16, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/28507681/complementary-oligonucleotides-regulate-induced-fit-ligand-binding-in-duplexed-aptamers
#6
Jeffrey D Munzar, Andy Ng, Mario Corrado, David Juncker
Duplexed aptamers (DAs) are engineered by hybridizing an aptamer-complementary element (ACE, e.g. a DNA oligonucleotide) to an aptamer; to date, ACEs have been presumed to sequester the aptamer into a non-binding duplex state, in line with a conformational selection-based model of ligand binding. Here, we uncover that DAs can actively bind a ligand from the duplex state through an ACE-regulated induced fit mechanism. Using a widely-studied ATP DNA aptamer and a solution-based equilibrium assay, DAs were found to exhibit affinities up to 1 000 000-fold higher than predicted by conformational selection alone, with different ACEs regulating the level of induced fit binding, as well as the cooperative allostery of the DA (Hill slope of 1...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28504003/different-metabolic-responses-induced-by-long-term-interdisciplinary-therapy-in-obese-adolescents-related-to-ace-i-d-polymorphism
#7
Sandro S Almeida, Flavia C Corgosinho, Carlos En Amorim, Marcos F Gregnani, Raquel Ms Campos, Deborah Cl Masquio, Priscila L Sanches, Aline P Ganen, João B Pesquero, Ana R Dâmaso, Marco T Mello, Sergio Tufik, Ronaldo C Araújo
INTRODUCTION: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. METHODS: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year...
April 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28500120/the-clinical-conundrum-of-diagnosing-and-treating-systemic-sarcoidosis-in-a-high-tb-burden-area
#8
Krishnadas Thulasidoss, Lavanya Asokan, Piyush Chandra, Pravinkumar Rejliwal
A 53-year-old woman from Southern India presented with weight loss, anorexia, fever and asthenia. Whole body positron emission tomography/computed tomography (PET-CT) showed fluorodeoxyglucose-avid mediastinal and abdominal lymphadenopathy with hepatic, splenic, parotid and lacrimal glandular inflammations. Endoscopic ultrasound-guided fine needle aspiration of subcarinal lymph node showed non-caseating granulomas. Initial serum ACE level was elevated but with normal calcium. Despite the suspicion of sarcoidosis, a trial of antituberculosis therapy was started empirically due to similar presentations of disseminated tuberculosis (TB) in this high endemic area...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28490619/capacity-for-diagnosis-and-treatment-of-heart-failure-in-sub-saharan-africa
#9
Selma Carlson, Herbert C Duber, Jane Achan, Gloria Ikilezi, Ali H Mokdad, Andy Stergachis, Alexandra Wollum, Gene Bukhman, Gregory A Roth
OBJECTIVE: Heart failure is a major cause of disease burden in sub-Saharan Africa (SSA). There is an urgent need for better strategies for heart failure management in this region. However, there is little information on the capacity to diagnose and treat heart failure in SSA. We aim to provide a better understanding of the capacity to diagnose and treat heart failure in Kenya and Uganda to inform policy planning and interventions. METHODS: We analysed data from a nationally representative survey of health facilities in Kenya and Uganda (197 health facilities in Uganda and 143 in Kenya)...
May 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28486091/angiotensin-receptors-in-dupuytren-s-disease-a-target-for-pharmacological-treatment
#10
Christopher Stephen, Leila Touil, Partha Vaiude, Jaipaul Singh, Stuart McKirdy
BACKGROUND: Attempts at the pharmacological treatment of Dupuytren's disease have so far been unsuccessful, and the disease is not yet fully understood on a cellular level. The Renin-Angiotensin System has long been understood to play a circulating hormonal role. However, there is much evidence showing Angiotensin II to play a local role in wound healing and fibrosis, with ACE inhibitors being widely used as an anti-fibrotic agent in renal and cardiac disease. METHODS: This study was designed to investigate the presence of Angiotensin II receptors 1 (AT1) and 2 (AT2) in Dupuytren's tissue to form a basis for further study into the pharmacological treatment of this condition...
May 9, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28475977/biotically-mediated-mercury-methylation-in-the-soils-and-sediments-of-nam-co-lake-tibetan-plateau
#11
Ming Ma, Hongxia Du, Dingyong Wang, Shichang Kang, Tao Sun
Previous research found that methylmercury (MeHg) levels in the fish of Nam Co Lake of Tibetan Plateau were remarkably higher than those obtained from Hg-polluted areas, probably indicating a stronger biomagnification and higher MeHg transfer efficient. Until now, little research has been carried out on the distribution of Hg methylators here, which maybe important to explain the higher fish MeHg levels. MeHg concentrations were remarkably different between the soil and sediment samples in both seasons. Illumina MiSeq sequencing of 16S rRNA gene amplicons showed that species richness estimates of the soil and sediment samples were both quite low based on Ace and Chao estimators...
May 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28457029/role-of-ace-and-il-1%C3%AE-gene-polymorphisms-in-erythropoeitin-hyporesponsive-patients-with-chronic-kidney-disease-with-anemia
#12
N Nand, A R Deshmukh, S Joshi, M P Sachdeva, Sakthivel
BACKGROUND: Hyporesponse to erythropoietin is a common problem seen in around 5-10% of patients. Recently the focus from these remediable factors has been shifted to the non-modifiable innate factors i.e polymorphism of ACE and IL-1B gene and studies have shown that DD genotype and IL-1B CC genotype have lower erythropoietin requirement. The aim of our study was to evaluate the role of ACE and IL-1B gene polymorphisms in erythropoietin hyporesponse in CKD patients with anemia. METHODS: A total of 50 patients were selected...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28456206/benchmark-coupled-cluster-g-tensor-calculations-with-full-inclusion-of-the-two-particle-spin-orbit-contributions
#13
Ajith Perera, Jürgen Gauss, Prakash Verma, Jorge A Morales
We present a parallel implementation to compute electron spin resonance g-tensors at the coupled-cluster singles and doubles (CCSD) level which employs the ACES III domain-specific software tools for scalable parallel programming, i.e., the super instruction architecture language and processor (SIAL and SIP), respectively. A unique feature of the present implementation is the exact (not approximated) inclusion of the five one- and two-particle contributions to the g-tensor [i.e., the mass correction, one- and two-particle paramagnetic spin-orbit, and one- and two-particle diamagnetic spin-orbit terms]...
April 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28455000/ethylglucuronide-in-the-urine-as-a-marker-of-alcohol-consumption-during-pregnancy-comparison-with-four-alcohol-screening-questionnaires
#14
Giampiero Ferraguti, Paola Ciolli, Valentina Carito, Gemma Battagliese, Rosanna Mancinelli, Stefania Ciafrè, Paola Tirassa, Rosaria Ciccarelli, Alessia Cipriani, Marisa Patrizia Messina, Marco Fiore, Mauro Ceccanti
Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strategies to reveal alcohol use have been planning including the use of screening questionnaires as the AUDIT-C, T-ACE and TWEAK. The present study aims to investigate in pregnant women the specificity and predictive value of the AUDIT-C, T-ACE and TWEAK plus a food diary in use in Sapienza University Hospital compared with the results of urine EtG measurement...
April 25, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28454704/the-normal-vaginal-and-uterine-bacterial-microbiome-in-giant-pandas-ailuropoda-melanoleuca
#15
Xin Yang, Guangyang Cheng, Caiwu Li, Jiang Yang, Jianan Li, Danyu Chen, Wencheng Zou, SenYan Jin, Hemin Zhang, Desheng Li, Yongguo He, Chengdong Wang, Min Wang, Hongning Wang
While the health effects of the colonization of the reproductive tracts of mammals by bacterial communities are widely known, there is a dearth of knowledge specifically in relation to giant panda microbiomes. In order to investigate the vaginal and uterine bacterial diversity of healthy giant pandas, we used high-throughput sequence analysis of portions of the 16S rRNA gene, based on samples taken from the vaginas (GPV group) and uteri (GPU group) of these animals. Results showed that the four most abundant phyla, which contained in excess of 98% of the total sequences, were Proteobacteria (59...
June 2017: Microbiological Research
https://www.readbyqxmd.com/read/28449585/elevated-plasma-a%C3%AE-42-in-cognitively-impaired-individuals-taking-ace-inhibitor-antihypertensives
#16
William T Regenold, Jacob B Blumenthal, David J Loreck, Kristen L Mordecai, Gina Scarinzi, Seshagiri R Doddi, Lawrence Adler
BACKGROUND/RATIONALE: Accumulating evidence suggests that the use of angiotensin-converting enzyme inhibitor (ACE-I) medication protects against cognitive decline in the elderly patients. We investigated whether ACE-I use was associated with higher plasma levels of amyloid-β (Aβ), possibly indicating improved Aβ clearance from brain to blood. METHODS: We measured and compared plasma concentrations of Aβ42, Aβ40, and creatinine in cognitively impaired individuals with amnestic mild cognitive impairment, probable Alzheimer's disease (AD) dementia, and mixed probable AD/vascular dementia...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28447366/effects-of-dietary-lysine-levels-on-the-concentrations-of-selected-nutrient-metabolites-in-blood-plasma-of-late-stage-finishing-pigs
#17
N Regmi, T Wang, M A Crenshaw, B J Rude, S F Liao
Lysine is the first-limiting amino acid (AA) in typical swine diets and plays very important roles in promoting growth performance of pigs. This research was conducted to study the effects of dietary lysine on blood plasma concentrations of protein, carbohydrate, and lipid metabolites of pigs. Eighteen crossbred finishing pigs (nine barrows and nine gilts; initial BW 92.3 ± 6.9 kg) were individually penned in an environment controlled barn. Pigs were assigned to three dietary treatments according to a randomized complete block design with gender as block and pig as experimental unit (6 pigs/treatment)...
April 26, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28445944/angiotensin-converting-enzyme-2-overexpression-protects-against-doxorubicin-induced-cardiomyopathy-by-multiple-mechanisms-in-rats
#18
Hui Ma, Jing Kong, Yu-Lin Wang, Jun-Long Li, Nai-Hao Hei, Xin-Ran Cao, Jing-Jing Yang, Wen-Jiang Yan, Wen-Jing Liang, Hong-Yan Dai, Bo Dong
Angiotensin-converting enzyme 2 (ACE2) is considered a potential therapeutic target of the renin-angiotensin system (RAS) for the treatment of cardiovascular diseases. We aimed to explore the effects of ACE2 overexpression on doxorubicin-induced cardiomyopathy in rats. Rats were randomly divided into treatment and control groups. The rats of treatment group were injected intraperitoneally with 6 doses of doxorubicin (2.5 mg/kg) within a period of two weeks. Two weeks after the initial injection of doxorubicin, these rats were randomly divided into Mock, Ad-EGFP, Ad-ACE2, and Cilazapril groups...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443021/functional-and-biochemical-endothelial-profiling-in-vivo-in-a-murine-model-of-endothelial-dysfunction-comparison-of-effects-of-1-methylnicotinamide-and-angiotensin-converting-enzyme-inhibitor
#19
Anna Bar, Mariola Olkowicz, Urszula Tyrankiewicz, Edyta Kus, Krzysztof Jasinski, Ryszard T Smolenski, Tomasz Skorka, Stefan Chlopicki
Although it is known that 1-methylnicotinamide (MNA) displays vasoprotective activity in mice, as yet the effect of MNA on endothelial function has not been demonstrated in vivo. Here, using magnetic resonance imaging (MRI) we profile the effects of MNA on endothelial phenotype in mice with atherosclerosis (ApoE/LDLR(-/-)) in vivo, in comparison to angiotensin (Ang) -converting enzyme (ACE) inhibitor (perindopril), with known vasoprotective activity. On a biochemical level, we analyzed whether MNA- or perindopril-induced improvement in endothelial function results in changes in ACE/Ang II-ACE2/Ang-(1-7) balance, and L-arginine/asymmetric dimethylarginine (ADMA) ratio...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28442323/the-ace-2-ang1-7-mas-cascade-enhances-bone-structure-and-metabolism-following-angiotensin-ii-type-1-receptor-blockade
#20
Hatem M Abuohashish, Mohammed M Ahmed, Dina Sabry, Mahmoud M Khattab, Salim S Al-Rejaie
The renin angiotensin system (RAS) regulates numerous systemic functions and is expressed locally in skeletal tissues. Angiotensin1-7 (Ang1-7) is a beneficial member of the RAS, and the therapeutic effects of a large number of angiotensin receptors blockers (ARBs) are mediated by an Ang1-7-dependent cascade. This study examines whether the reported osteo-preservative effects of losartan are mediated through the angiotensin converting enzyme2 (ACE-2)/Ang1-7/Mas pathway in ovariectomized (OVX) rats. Sham and OVX animals received losartan (10mg/kg/d p...
April 22, 2017: European Journal of Pharmacology
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