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https://www.readbyqxmd.com/read/29044123/ire1%C3%AE-xbp1s-branch-of-upr-links-hif1%C3%AE-activation-to-mediate-angii-dependent-endothelial-dysfunction-under-particulate-matter-pm-2-5-exposure
#1
Xiuduan Xu, Aodeng Qimuge, Hongli Wang, Chen Xing, Ye Gu, Shasha Liu, Huan Xu, Meiru Hu, Lun Song
Short- and long-term exposure to particulate matter (PM) 2.5 instigates adverse health effect upon the cardiovascular (CV) system. Disclosing the molecular events by which PM2.5 evokes CV injuries is essential in developing effective risk-reduction strategy. Here we found that rats after intratracheally instillation with PM2.5 displayed increased circulating level of ANGII, the major bioactive peptide in renin-angiotensin-system (RAS), which resulted from the elevation of ANGII production in the vascular endothelium...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044064/utility-of-angiotensin-converting-enzyme-activity-in-aqueous-humor-in-the-diagnosis-of-ocular-sarcoidosis
#2
Violeta Mihailovic-Vucinic, Ljubica Popevic, Spasoje Popevic, Mihailo Stjepanovic, Andjelka Aleksic, Anka Stanojevic-Paovic
PURPOSE: Many studies include elevated activity of angiotensin-converting enzyme (ACE) in serum in sarcoidosis and in ocular sarcoidosis as well, but there are only a few analyzing ACE activities in aqueous humor. The aim of this study is to illuminate the diagnostic value of ACE in aqueous humor in patients with ocular sarcoidosis. METHODS: We analyzed twenty patients with ocular sarcoidosis and 18 patients with nonocular involvement. All patients have biopsy-positive sarcoidosis of the lungs and/or mediastinal lymph nodes...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29040943/liquid-chromatography-tandem-mass-spectrometry-direct-injection-analysis-of-organophosphorus-flame-retardants-in-ontario-surface-water-and-wastewater-effluent
#3
Chunyan Hao, Paul A Helm, David Morse, Eric J Reiner
Organophosphorus flame retardants (OPFRs) started to be used in plastics, electronics and furnishings back in the 1960s and became popular again last decade. They are now widely present in the environment and regarded as "new" emerging organic pollutants. An effective liquid chromatography-tandem mass spectrometry (LC-MS/MS) direct injection analysis (DIA) method was developed to monitor OPFR levels in aquatic environment. The removal of sample extraction and concentration steps not only improved operation efficiency, but also reduced the potential contamination commonly observed during the sample preparation process before...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29028685/use-of-genetic-algorithm-combinational-single-nucleotide-polymorphisms-could-modify-the-association-of-blood-lead-levels-and-bone-matrix-density
#4
Chien-Juan Chen, Hsueh-Wei Chang, Cheng-Hong Yang, Hung-Yi Chuang, Hsin-Su Yu
BACKGROUND: Previous studies have not explored the relationship between a single gene and a single disease. Our study aims to investigate the association of multiple genotypes with blood lead levels and bone matrix density (BMD) by using genetic algorithms. METHODS: Our research focused on 506 employees (245 males and 261 females) of a lead battery factory in Taiwan. We collected data on their BMD, blood lead level, and 6 SNPs (ACE, alpha-adducin, Bsm, Tag, Apa, and ALAD); these factors were analyzed using discrete binary particle swarm optimization (DBPSO) and logistic regression analysis...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028160/angiotensin-converting-enzyme-insertion-deletion-gene-polymorphism-in-egyptian-children-with-cap-a-case-control-study
#5
Heba Abouzeid, Usama M Alkholy, Mohammed A Abdou, Saeed M Morsy, Hind M Abdelrahman, Ashraf M Sherif, Nermin Abdalmonem, Mohammed E Hamed, Mayy A N Allah, Salah Al Morshedy, Shaimaa S A Elashkar, Maha A Noah, Mohamed S Hegab, Nagwa E Akeel, Mustafa I A Hashem, Heba H Gawish, Lobna Abdel Fattah
BACKGROUND: Community-acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for CAP risk. OBJECTIVES: In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29026308/role-of-poly-%C3%AE%C2%B5-caprolactone-lipid-core-nanocapsules-on-melanoma-neutrophil-crosstalk
#6
Carine C Drewes, Aline de Cs Alves, Cristina B Hebeda, Isabela Copetti, Silvana Sandri, Mayara K Uchiyama, Koiti Araki, Silvia S Guterres, Adriana R Pohlmann, Sandra H Farsky
Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29025849/the-association-between-adverse-childhood-experiences-and-traumatic-brain-injury-concussion-in-adulthood-a-scoping-review-protocol
#7
Zechen Ma, Mark T Bayley, Laure Perrier, Priya Dhir, Lana Dépatie, Paul Comper, Lesley Ruttan, Sarah Ep Munce
INTRODUCTION: Exposure to adverse childhood experiences (ACEs) is a significant risk factor for physical and mental illnesses later in life. Concussion or traumatic brain injury is a challenging condition where preinjury factors may interact to affect recovery. The association between ACEs and traumatic brain injury/concussion is not well mapped in any previous reviews of the literature. Using a scoping review methodology, the research question that will be addressed is: what is known from the existing literature about the association between ACEs and traumatic brain injury/concussion in adults? METHODS AND ANALYSIS: The methodological frameworks outlined by Arksey and O'Malley and Levac et al will be used...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29022534/therapeutic-drug-monitoring-of-amlodipine-and-the-z-fhl-hhl-ratio-adherence-tools-in-patients-referred-for-apparent-treatment-resistant-hypertension
#8
E S W Jones, M Lesosky, M Blockman, S Castel, E H Decloedt, S L U Schwager, E D Sturrock, L Wiesner, B L Rayner
BACKGROUND: Non-adherence to antihypertensives is a cause of 'pseudo-treatment-resistant' hypertension. OBJECTIVE: To determine whether monitoring plasma amlodipine concentrations and inhibition of angiotensin-converting enzyme (ACE) can be adjunct adherence tools. METHODS: Patients with hypertension who were prescribed enalapril and amlodipine were enrolled. Blood pressures (BPs) were monitored and an adherence questionnaire was completed...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29018418/microbial-diversity-in-a-hypersaline-sulfate-lake-a-terrestrial-analog-of-ancient-mars
#9
Alexandra Pontefract, Ting F Zhu, Virginia K Walker, Holli Hepburn, Clarissa Lui, Maria T Zuber, Gary Ruvkun, Christopher E Carr
Life can persist under severe osmotic stress and low water activity in hypersaline environments. On Mars, evidence for the past presence of saline bodies of water is prevalent and resulted in the widespread deposition of sulfate and chloride salts. Here we investigate Spotted Lake (British Columbia, Canada), a hypersaline lake with extreme (>3 M) levels of sulfate salts as an exemplar of the conditions thought to be associated with ancient Mars. We provide the first characterization of microbial structure in Spotted Lake sediments through metagenomic sequencing, and report a bacteria-dominated community with abundant Proteobacteria, Firmicutes, and Bacteroidetes, as well as diverse extremophiles...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29016159/an-examination-of-the-test-retest-reliability-of-the-ace-sq-in-a-sample-of-college-athletes
#10
Danielle C Zanotti, Emily Kaier, Renee Vanasse, Joanne L Davis, Kathleen C Strunk, Lisa DeMarni Cromer
OBJECTIVE: The Adverse Childhood Experiences (ACE) study is one of the largest studies ever conducted that has examined the relationship of childhood abuse, neglect, and family dysfunction to subsequent health and well-being later in life. Questions from the ACE study evolved into the ACE Study Questionnaire, a measure used for assessing individuals' self-reported experiences of childhood adversity. The ACE measure is widely available and the Centers for Disease Control and Prevention (CDC) recommends it as a tool for assessing one's lifetime risk of mental and physical health problems and other negative social problems...
October 9, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28993445/adverse-childhood-experiences-among-hispanic-children-in-immigrant-families-versus-us-native-families
#11
Tania Maria Caballero, Sara B Johnson, Cara R Muñoz Buchanan, Lisa Ross DeCamp
OBJECTIVES: To examine the prevalence of child and family characteristics associated with adverse childhood experiences (ACEs) in Hispanic children in immigrant families compared with Hispanic children in US-native families. METHODS: Data were from the nationally representative 2011-2012 National Survey of Children's Health. Parent-reported child ACE exposure was classified as no ACEs (0), low ACEs (1), or high ACEs (≥2). By using multinomial logistic regression, we evaluated the odds of low or high ACE exposure versus no ACE exposure by immigrant family status and child and family characteristics (eg, insurance status, child health status, or household-to-income ratio)...
October 9, 2017: Pediatrics
https://www.readbyqxmd.com/read/28992958/positive-childhood-experiences-predict-less-psychopathology-and-stress-in-pregnant-women-with-childhood-adversity-a-pilot-study-of-the-benevolent-childhood-experiences-bces-scale
#12
Angela J Narayan, Luisa M Rivera, Rosemary E Bernstein, William W Harris, Alicia F Lieberman
This pilot study examined the psychometric properties of the Benevolent Childhood Experiences (BCEs) scale, a new instrument designed to assess positive early life experiences in adults with histories of childhood maltreatment and other adversities. A counterpart to the Adverse Childhood Experiences (ACEs) questionnaire, the BCEs was developed to be multiculturally-sensitive and applicable regardless of socioeconomic position, urban-rural background, or immigration status. Higher levels of BCEs were hypothesized to predict lower levels of psychopathology and stress beyond the effects of ACES in a sample of ethnically diverse, low-income pregnant women...
October 6, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28992224/modulation-of-leucocytic-angiotensin-converting-enzymes-expression-in-patients-maintained-on-high-permeable-haemodialysis
#13
Bogusz Trojanowicz, Christof Ulrich, Roman Fiedler, Peter Martus, Markus Storr, Torsten Boehler, Kristin Werner, Michael Hulko, Daniel Zickler, Kevin Willy, Ralf Schindler, Matthias Girndt
Background: High mortality of haemodialysis patients is associated with systemic chronic inflammation and overactivation of the renin-angiotensin system (RAS). Insufficient elimination of pro-inflammatory immune mediators, especially in the molecular weight range of 15-45 kDa, may be one of the reasons for this. Employment of haemodialysis membranes with increased permeability was shown to ameliorate the inflammatory response and might modulate the effects of local RAS. In this study, we tested the impact of high cut-off (HCO), medium cut-off (MCO) and high-flux (HF) dialysis on leucocytic transcripts of angiotensin-converting enzymes (ACE and ACE2)...
July 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28987631/ovariectomy-modify-local-renin-angiotensin-aldosterone-system-gene-expressions-in-the-heart-of-apoe-mice
#14
Celina Carvalho Borges, Aline Penna-de-Carvalho, Jorge L Medeiros Junior, Marcia Barbosa Aguila, Carlos A Mandarim-de-Lacerda
AIMS: The evaluation of the local Renin-Angiotensin-Aldosterone system (RAAS) gene expressions in the heart of ovariectomized (OVX) apolipoprotein E deficient mice (ApoE). METHODS: Four-months old C57BL/6 female mice (wild-type, wt, n=20), and ApoE female mice (n=20), were submitted to OVX or a surgical procedure without ovary removal (SHAM) and formed four groups (n=10/group): SHAM/wt, SHAM/ApoE, OVX/wt, and OVX/ApoE. KEY FINDINGS: OVX led to greater body mass, plasma triglycerides (TG) and total cholesterol, and resulted in insulin resistance and altered RAAS gene expressions in the heart tissue...
October 4, 2017: Life Sciences
https://www.readbyqxmd.com/read/28987480/egg-white-derived-peptides-prevent-cardiovascular-disorders-induced-by-mercury-in-rats-role-of-angiotensin-converting-enzyme-ace-and-nadph-oxidase
#15
Danize Aparecida Rizzetti, Ángela Martín, Patricia Corrales, Francisca Fernandez, Maylla Ronacher Simões, Franck Maciel Peçanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
The study aimed to investigate the effects of egg white hydrolysate (EWH) on vascular disorders induced by mercury (Hg). For this, male Wistar rats were treated for 60days: Untreated (saline, i.m.); Mercury (HgCl2, i.m., 1st dose 4.6μg/kg, subsequent doses 0.07μg/kg/day); Hydrolysate (EWH, gavage, 1g/kg/day); Hydrolysate-Mercury. Systolic (SBP) and diastolic (DBP) blood pressure measurement and vascular reactivity experiments in aorta were performed. We analyzed endothelial dependent and independent vasodilator responses and vasoconstrictor response to phenylephrine (Phe) in absence and presence of endothelium, a NOS inhibitor, a NADPH oxidase inhibitor, the superoxide dismutase, a non-selective COX inhibitor, a selective COX-2 inhibitor, an AT-1 receptors blocker...
October 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28980279/secondary-prevention-of-coronary-heart-disease-in-elderly-population-of-turkey-a-subgroup-analysis-of-elderturk-study
#16
Salih Kilic, Mutlu Çagan Sümerkan, Volkan Emren, Lütfü Bekar, Sinan Çersit, Elif Tunç, Gülay Gök, Emine Altuntas, Uğur Canpolat, Umit Yasar Sinan, Namık Özmen, Mehdi Zoghi
BACKGROUND: Secondary prevention plays an important role after acute coronary event due to high risk of adverse events in elderly. In present study we aimed to evaluate the lifestyle, management of risk factors and medical treatment for secondary protection in elderly patients with known coronary heart disease (CHD). METHODS: ELDERTURK is a non-interventional, multi-centered, observational study, which included total of 5694 elderly patients (> 65 years) from 50 centers in Turkey...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28975444/economic-hardship-in-childhood-a-neglected-issue-in-ace-studies
#17
Paula Braveman, Katherine Heck, Susan Egerter, Christine Rinki, Kristen Marchi, Mike Curtis
Objectives Adverse childhood experiences (ACEs) have been linked with ill-health in adulthood, but ACE literature has focused on family disruption or dysfunction (e.g., child abuse, parental separation), with less attention to economic adversity. We examined whether a mother's economic hardship in childhood (EHC) was associated with women's hardships and health-risk behaviors during/just before pregnancy. Methods We analyzed population-based survey data on 27,102 postpartum California women. EHC included respondents' reports that during childhood they/their families experienced hunger because of inability to afford food or moved because of problems paying rent/mortgage and the frequency of difficulty paying for basic needs...
October 3, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28973758/assessment-of-the-rs4340-ace-gene-polymorphism-in-acute-coronary-syndrome-in-a-western-mexican-population
#18
A Valdez-Haro, Y Valle, E Valdes-Alvarado, F Casillas-Muñoz, J F Muñoz-Valle, G L Reynoso-Villalpando, H E Flores-Salinas, J R Padilla-Gutiérrez
Acute coronary syndrome (ACS) is considered one of the main causes of death worldwide. Contradictory findings concerning the impact of the angiotensin-converting enzyme (ACE) gene on cardiovascular diseases have been reported. Previous conclusions point out that the variability in results depends on ethnicity and genetic polymorphisms to determine the association of rs4340 polymorphisms of the ACE gene and ACE circulating levels in ACS. Genotyping of rs4340 polymorphisms was performed in a total of 600 individuals from Western Mexico divided into two groups: the ACS and the control group (CG)...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28964767/the-angiotensin-converting-enzyme-ace-inhibitor-captopril-disrupts-the-motility-activation-of-sperm-from-the-silkworm-bombyx-mori
#19
Sumiharu Nagaoka, Saori Kawasaki, Hideki Kawasaki, Kaeko Kamei
Angiotensin I-converting enzyme (also known as peptidyl dicarboxypeptidase A, ACE, and EC 3.4.15.1), which is found in a wide range of organisms, cleaves C-terminal dipeptides from relatively short oligopeptides. Mammalian ACE plays an important role in the regulation of blood pressure. However, the precise physiological functions of insect ACE homologs have not been understood. As part of our effort to elucidate new physiological roles of insect ACE, we herein report a soluble ACE protein in male reproductive secretions from the silkmoth, Bombyx mori...
September 28, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28961102/discriminative-multiple-instance-hyperspectral-target-characterization
#20
Alina Zare, Changzhe Jiao, Taylor Glenn
In this paper, two methods for discriminative multiple instance target characterization, MI-SMF and MI-ACE, are presented. MI-SMF and MI-ACE estimate a discriminative target signature from imprecisely-labeled and mixed training data. In many applications, such as sub-pixel target detection in remotely-sensed hyperspectral imagery, accurate pixel-level labels on training data is often unavailable and infeasible to obtain. Furthermore, since sub-pixel targets are smaller in size than the resolution of a single pixel, training data is comprised only of mixed data points (in which target training points are mixtures of responses from both target and non-target classes)...
September 26, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
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