keyword
MENU ▼
Read by QxMD icon Read
search

ACE levels

keyword
https://www.readbyqxmd.com/read/27913661/effects-of-exendin-4-on-the-intrarenal-renin-angiotensin-system-and-interstitial-fibrosis-in-unilateral-ureteral-obstruction-mice-exendin-4-and-unilateral-ureteral-obstruction
#1
Ying Le, Zongji Zheng, Junyu Xue, Mengling Cheng, Meiping Guan, Yaoming Xue
OBJECTIVE: The objective of this article is to investigate the renoprotecive effects of exendin-4 in a mouse model of unilateral ureteral obstruction (UUO) and explore the putative mechanisms. METHODS: Male Balbc mice underwent sham operation or UUO surgery, and then received intraperitoneal injection of vehicle or exendin-4, respectively. After 14 days, mice were sacrificed and the left kidneys were collected and analyzed by histology, immunohistochemistry, Western blot, quantitative real-time reverse transcription polymerase chain reaction, radioimmunoassay and enzyme-linked immunosorbent assay...
October 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27897084/multi-spectroscopic-and-molecular-modeling-studies-of-interaction-between-two-different-angiotensin-i-converting-enzyme-inhibitory-peptides-from-gluten-hydrolysate-and-human-serum-albumin
#2
Reza Assaran Darban, Behzad Shareghi, Ahmad Asoodeh, Jamshidkhan Chamani
The present study was carried out to characterize ACE inhibitory peptides which are release from the trypsin hydrolysate of wheat gluten protein. The binding of two inhibitory peptide (P4 and P6) to human serum albumin (HSA) under physiological conditions has been investigated by multi- spectroscopic in combination with molecular modeling techniques. Time-resolved and quenching fluorescence spectroscopies results revealed that the quenching of HSA fluorescence by P4 and P6 in the binary and ternary systems caused HSA-peptides complexes formation...
November 29, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27884507/childhood-adversity-and-the-risk-of-substance-use-and-delinquency-the-role-of-protective-adult-relationships
#3
Samantha M Brown, Audrey M Shillington
Youth involved in the child welfare system experience multiple early adversities that can contribute to increased risk of substance use and delinquency. Although adverse childhood experiences (ACEs) have been associated with poorer behavioral outcomes among youth, less is known about the possible protective factors that may influence the relationship between early adversity and risk-taking behavior. This study examined whether protective adult relationships moderated the link between cumulative ACEs and substance use and delinquency after controlling for demographic characteristics in child welfare-involved youth...
November 21, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27884212/angiotensin-converting-enzyme-2-is-reduced-in-alzheimer-s-disease-in-association-with-increasing-amyloid-%C3%AE-and-tau-pathology
#4
Patrick Gavin Kehoe, Steffenny Wong, Noura Al Mulhim, Laura Elyse Palmer, J Scott Miners
BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer's disease (AD). Angiotensin-converting enzyme-2 (ACE-2) degrades Ang II to angiotensin 1-7 (Ang (1-7)) and counter-regulates the classical axis of RAS. We have investigated the expression and distribution of ACE-2 in post-mortem human brain tissue in relation to AD pathology and classical RAS axis activity...
November 25, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27878240/sirt1-activator-represses-the-transcription-of-tnf%C3%A2-%C3%AE-in-thp%C3%A2-1-cells-of-a-sepsis-model-via-deacetylation-of-h4k16
#5
Guo-Dong Chen, Wei-Dong Yu, Xiao-Ping Chen
Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, comprising lipopolysaccharide (LPS)‑tolerant THP‑1 cells, was used to investigate whether the SirT1 activator, resveratrol, repressed the transcription of TNF‑α. Chromatin immunoprecipitation and real‑time PCR were used to determine the transcription of the TNF‑α promoter...
November 15, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27875990/inverse-relationship-between-alzheimer-s-disease-and-cancer-and-other-factors-contributing-to-alzheimer-s-disease-a-systematic-review
#6
Ovais Shafi
BACKGROUND: The AD etiology is yet not properly known. Interactions among environmental factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the factors that play role in causing AD and how changes in cellular pathways contribute to AD. METHODS: PUBMED database, MEDLINE database and Google Scholar were searched with no date restrictions for published articles involving cellular pathways with roles in cancers, cell survival, growth, proliferation, development, aging, and also contributing to Alzheimer's disease...
November 22, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27860389/efficacy-and-safety-of-two-dosages-of-canrenone-as-add-on-therapy-in-hypertensive-patients-taking-ace-inhibitors-or-angiotensin-ii-receptor-blockers-and-hydrochlorothiazide-at-maximum-dosage-in-a-randomized-clinical-trial-the-escape-it-trial
#7
Giuseppe Derosa, Pamela Maffioli, Maria D'Avino, Carla Sala, Amedeo Mugellini, Vito Vulpis, Salvatore Felis, Luigina Guasti, Riccardo Sarzani, Alessandro Bestetti, Massimo Vanasia, Giovanni Gaudio
AIM: To evaluate the effects of canrenone as add-on therapy in patients already treated with angiotensin converting-enzyme inhibitors (ACE-I) or angiotensin II receptor blockers (ARBs) and hydrochlorothiazide at the maximum dosage (25 mg/day). METHOD: In this randomized, open label, controlled trial, we enrolled 175 Caucasian patients with essential hypertension not well controlled by concomitant ACE-I or ARBs and hydrochlorothiazide. At baseline 87 patients (57 males and 30 females) were randomized to add canrenone 50 mg, and 88 (56 males and 32 females) patients to canrenone 100 mg, once a day, for three months...
November 12, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27859508/embodied-simulations-are-modulated-by-sentential-perspective
#8
Wessel O van Dam, Rutvik H Desai
There is considerable evidence that language comprehenders derive lexical-semantic meaning by mentally simulating perceptual and motor attributes of described events. However, the nature of these simulations-including the level of detail that is incorporated and contexts under which simulations occur-is not well understood. Here, we examine the effects of first- versus third-person perspective on mental simulations during sentence comprehension. First-person sentences describing physical transfer towards or away from the body (e...
November 17, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27855503/inhibitory-activities-of-cystoseira-crinita-sulfated-polysaccharide-on-key-enzymes-related-to-diabetes-and-hypertension-in-vitro-and-animal-study
#9
Amel Ben Gara, Rihab Ben Abdallah Kolsi, Neila Jardak, Rim Chaaben, Abdelfattah El-Feki, Lotfi Fki, Hafedh Belghith, Karima Belghith
The present study investigated the effect of the Cystoseira crinita sulfated polysaccharide (CCSP) on key enzymes activities related to diabetes in vitro and in diabetic rats. We found that CCSP inhibited pancreatic α-amylase with IC50 = 39.16 μg/ml and angiotensin I-converting enzyme (ACE) activity with IC50 = 58.35 μg/ml in vitro. In diabetic rats, the administration of CCSP reduced the activity of α-amylase in serum, pancreas, and intestine by 23%, 44.38%, and 45%, respectively as compared to untreated diabetic rats...
November 18, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27854209/aceneuramic-acid-extended-release-administration-maintains-upper-limb-muscle-strength-in-a-48-week-study-of-subjects-with-gne-myopathy-results-from-a-phase-2-randomized-controlled-study
#10
Zohar Argov, Yoseph Caraco, Heather Lau, Alan Pestronk, Perry B Shieh, Alison Skrinar, Tony Koutsoukos, Ruhi Ahmed, Julia Martinisi, Emil Kakkis
BACKGROUND: GNE Myopathy (GNEM) is a progressive adult-onset myopathy likely caused by deficiency of sialic acid (SA) biosynthesis. OBJECTIVE: Evaluate the safety and efficacy of SA (delivered by aceneuramic acid extended-release [Ace-ER]) as treatment for GNEM. METHODS: A Phase 2, randomized, double-blind, placebo-controlled study evaluating Ace-ER 3 g/day or 6 g/day versus placebo was conducted in GNEM subjects (n = 47). After the first 24 weeks, placebo subjects crossed over to 3 g/day or 6 g/day for 24 additional weeks (dose pre-assigned during initial randomization)...
March 3, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27846783/point-of-care-assessment-of-cardiac-troponin-t-level-in-ckd-patients-with-chest-symptom
#11
Masaki Iwasaki, Kenji Yamazaki, Nobutaka Ikeda, Yuri Tanaka, Toshihide Hayashi, Shun Kubo, Ai Matsukane, Hiroki Hase, Nobuhiko Joki
We challenged to identify the cutoff value of cTnT in chronic kidney disease (CKD) patients by point of care assessment way. A single center, prospective cross-sectional study was planned and performed. 201 consecutive patients who were visited emergency room for chest symptoms were enrolled in this study. All patients were performed routine practice for differential diagnosis of chest symptom by cardiologist. Simultaneously, semiquantitative measurement of cTnT was performed using same blood sampling on the blind condition to cardiologists for this study...
November 15, 2016: Renal Failure
https://www.readbyqxmd.com/read/27844290/potentiation-of-paclitaxel-induced-pain-syndrome-in-mice-by-angiotensin-i-converting-enzyme-inhibition-and-involvement-of-kinins
#12
Indiara Brusco, Cássia Regina Silva, Gabriela Trevisan, Camila de Campos Velho Gewehr, Flávia Karine Rigo, Lidia La Rocca Tamiozzo, Mateus Fortes Rossato, Raquel Tonello, Gerusa Duarte Dalmolin, Daniela de Almeida Cabrini, Marcus Vinícius Gomez, Juliano Ferreira, Sara Marchesan Oliveira
Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin receptor signalling. The goal of this study was to evaluate the role of kinins on paclitaxel-associated acute pain syndromes (P-APS) and the effect of ACE inhibition on P-APS and paclitaxel-associated chronic peripheral neuropathy (P-CPN) in mice...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27830352/antioxidant-and-antihypertensive-potential-of-protein-fractions-from-flour-and-milk-substitutes-from-canary-seeds-phalaris-canariensis-l
#13
María Elena Valverde, Domancar Orona-Tamayo, Blanca Nieto-Rendón, Octavio Paredes-López
Canary seed (Phalaris canariensis) is used to feed birds but it has been recently considered a promising cereal with nutraceutical potential for humans. The aim of this work was to analyze the protein fractions from canary seed flour and from milk substitutes (prepared by soaking the seeds in water 12 and 24 h), and to evaluate antioxidant and antihypertensive capacity of peptides obtained after in vitro digestion. Prolamins were the major protein fraction, followed by glutelins. After digestion, albumins and prolamins fractions from milks presented higher levels of peptides than flour, globulins showed more peptides in flour and glutelins were found in similar concentrations in all samples; 24 h milk prolamins had the highest concentration of peptides...
November 9, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27829696/plasma-levels-of-pentosidine-carboxymethyl-lysine-soluble-receptor-for-advanced-glycation-end-products-and-metabolic-syndrome-the-metformin-effect
#14
Mohamed Haddad, Ines Knani, Hsan Bouzidi, Olfa Berriche, Mohamed Hammami, Mohsen Kerkeni
Metabolic syndrome (MetS) is considered one of the most important public health problems. Several and controversial studies showed that the role of advanced glycation end products (AGEs) and their receptor in the development of metabolic syndrome and therapeutic pathways is still unsolved. We have investigated whether plasma pentosidine, carboxymethyl-lysine (CML), and soluble receptor for advanced glycation end products (sRAGE) levels were increased in patients with MetS and the effect of metformin in plasma levels of pentosidine, CML, and sRAGE...
2016: Disease Markers
https://www.readbyqxmd.com/read/27821539/endothelial-microparticles-from-acute-coronary-syndrome-patients-induce-premature-coronary-artery-endothelial-cells-ageing-and-thrombogenicity-role-of-the-ang-ii-at1-receptor-nadph-oxidase-mediated-activation-of-mapks-and-pi3-kinase-pathways
#15
Malak Abbas, Laurence Jesel, Cyril Auger, Lamia K Amoura, Nathan Messas, Guillaume Manin, Cordula Rumig, Antonio J León-González, Thais P Ribeiro, Grazielle C Silva, Raghida Abou-Merhi, Eva Hamade, Markus Hecker, Yannick Georg, Nabil Chakfe, Patrick Ohlmann, Valérie B Schini-Kerth, Florence Toti, Olivier Morel
BACKGROUND: -Microparticles (MPs) have emerged as a surrogate marker of endothelial dysfunction and cardiovascular risk. This study examined the potential of MPs from senescent endothelial cells (ECs) or from patients with acute coronary syndrome (ACS) to promote premature ECs ageing and thrombogenicity. METHODS: -Primary porcine coronary ECs were isolated from the left circumflex coronary artery. MPs were prepared from ECs and venous blood from patients with ACS (n=30) and from healthy volunteers (n=6) by sequential centrifugation...
November 7, 2016: Circulation
https://www.readbyqxmd.com/read/27817835/contemporary-short-and-long-term-outcomes-in-patients-with-unremitting-constipation-and-fecal-incontinence-treated-with-an-antegrade-continence-enema
#16
Scott C Dolejs, John K Smith, Justin Sheplock, Joseph M Croffie, Frederick J Rescorla
PURPOSE: The primary aim of this study is to determine the natural history of patients who undergo an antegrade continence enema (ACE) procedure including complications, functional results, and long-term outcomes. METHODS: Patients aged 3-18years who underwent an ACE procedure from 2008 to 2015 for unremitting constipation and fecal incontinence with at least thirty day follow-up were included. Patients with congenital anatomic disorders of the spine, rectum, and anus were excluded...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27815252/chymase-dependent-production-of-angiotensin-ii-an-old-enzyme-in-old-hearts
#17
Ghezal Froogh, John T Pinto, Yicong Le, Sharath Kandhi, Yeabsra Aleligne, An Huang, Dong Sun
Age-dependent alteration of the renin-angiotensin-system (RAS) and generation of angiotensin II (Ang II) are well documented. By contrast, RAS-independent generation of angiotensin II in aging and its responses to exercise have not been explored. To this end, we examined the effects of chymase, a secretory serine protease, on the angiotensin converting enzyme (ACE)-independent conversion of Ang I to Ang II. We hypothesize that age-dependent alteration of cardiac Ang II formation is chymase-dependent in nature and is prevented by exercise training...
November 4, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27814397/the-interplay-between-the-renin-angiotensin-system-and-pacing-postconditioning-induced-cardiac-protection
#18
Fawzi Babiker, Aishah Al-Jarallah, Shaji Joseph
BACKGROUND: Accumulating evidence suggests a cardioprotective role of pacing postconditioning (PPC) maneuvers in animal models and more recently in humans. The procedure however remains to be optimized and its interaction with physiological systems remains to be further explored. The renin angiotensin system (RAS) plays a dual role in ischemia/reperfusion (I/R) injury. The interaction between RAS and PPC induced cardiac protection is however not clearly understood. We have recently demonstrated that angiotensin (1-7) via Mas receptor played a significant role in PPC mediated cardiac protection against I/R injury...
2016: PloS One
https://www.readbyqxmd.com/read/27806896/racial-ethnic-differences-in-the-association-of-childhood-adversities-with-depression-and-the-role-of-resilience
#19
Nagy A Youssef, Daniel Belew, Guang Hao, Xiaoling Wang, Frank A Treiber, Michael Stefanek, Mark Yassa, Elizabeth Boswell, W Vaughn McCall, Shaoyong Su
BACKGROUND: Adverse childhood experiences (ACE) including childhood abuse and trauma increase depressive symptoms. The role of resilience and how it interacts with both ACEs and the potential development of depressive symptoms, including how race and ethnicity moderate these effects, are much less studied. The aims of this study were to examine: 1) whether there is a dose-response relationship between trauma and depressive symptoms; 2) whether early trauma affected European Americans (EA) and African Americans (AA) in a similar fashion; and 3) whether resilience mitigates the effect of trauma...
October 24, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27806107/role-of-patient-and-practice-characteristics-in-variance-of-treatment-quality-in-type-2-diabetes-between-general-practices
#20
Yeon Young Cho, Grigory Sidorenkov, Petra Denig
BACKGROUND: Accounting for justifiable variance is important for fair comparisons of treatment quality. The variance between general practices in treatment quality of type 2 diabetes (T2DM) patients may be attributed to the underlying patient population and practice characteristics. The objective of this study is to describe the between practice differences in treatment, and identify patient and practice level characteristics that may explain these differences. METHODS: The data of 24,607 T2DM patients from 183 general practices in the Netherlands were used...
2016: PloS One
keyword
keyword
60953
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"