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https://www.readbyqxmd.com/read/29777841/acute-ischemic-pancreatitis-secondary-to-aortic-dissection
#1
Rong Wang, Jun-Ming Zhu, Rui-Dong Qi, Yong-Min Liu, Jun Zheng, Nan Zhang, Li-Zhong Sun
OBJECTIVE: Acute ischemic pancreatitis secondary to aortic dissection is very rare with an unclarified mechanism. We retrospectively reviewed six such cases in our center and present their outcomes herein. MATERIAL AND METHODS: Between February 2009 and April 2017, six patients (male=2, female=4; mean age, 58 ± 8, range 47-70) years) with acute aortic dissection associated with pancreatitis were admitted to our center. There were three type A and three type B dissections...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777839/-mesenteric-steal-physiology-as-a-cause-of-claudication-and-chronic-mesenteric-ischemia
#2
Aleem K Mirza, J Michael Bacharach
Aortoiliac occlusive disease (AOID) results in varying degrees of pelvic and lower extremity arterial insufficiency. Treatment approach has evolved and endovascular therapies are being successfully reported for high-grade lesion. However, Trans Atlantic Inter-Society Consensus (TASC) D often necessitates open revascularization. Disease limited to the infrarenal segment does not typically affect intestinal perfusion in the absence of visceral aortic or mesenteric vessel involvement. Chronic mesenteric ischemia most commonly occurs due to atherosclerotic disease of two or three of the mesenteric vessels...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777240/serum-25-hydroxyvitamin-d-and-cardiovascular-disease-risk-factors-in-women-with-excessive-weight-gain-during-pregnancy-and-in-their-offspring-at-age-5-6-years
#3
Gemma Carreras-Badosa, Cristina Armero-Bujaldón, Laia Solé-Amat, Anna Prats-Puig, Ferran Díaz-Roldán, Pilar Soriano-Rodriguez, Francis de Zegher, Lourdes Ibañez, Judit Bassols, Abel López-Bermejo
BACKGROUND/OBJECTIVE: Low 25-hydroxyvitamin D levels [25(OH)D] may increase the risk for cardiovascular disease (CVD). In pregnant women excessive weight gain and 25(OH)D deficiency are common complications and both could have deleterious consequences on their children. We aimed to study the relationship between serum 25(OH)D and CVD risk factors in pregnant women and in their offspring at school age. SUBJECTS/METHODS: Fasting serum 25(OH)D and its bioavailable fraction were quantified in 310 healthy pregnant women [with adequate (n = 113), insufficient (n = 113) and excessive (n = 84) weight gain]...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29777233/visceral-adiposity-and-high-adiponectin-levels-are-associated-with-the-prevalence-of-pancreatic-cystic-lesions
#4
Suguru Mizuno, Yousuke Nakai, Hiroyuki Isayama, Takeharu Yoshikawa, Kei Saito, Naminatsu Takahara, Hirofumi Kogure, Minoru Tada, Naoto Hayashi, Kazuhiko Koike
OBJECTIVES: Obesity is increasing in developed countries and is a risk factor for pancreatic cancer (PaC). We previously reported that obesity was associated with pancreatic cystic lesions (PCLs), which are both precursors of, and risk factors for, PaC. In the present study, we further investigated the relationship between visceral adiposity and adiponectin levels and the extent of PCLs. METHODS: Individuals who underwent comprehensive health screening at our institution between January 2008 and March 2013 were analyzed...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29776968/liraglutide-modulates-appetite-and-body-weight-via-glp-1r-expressing-glutamatergic-neurons
#5
Jessica M Adams, Hongjuan Pei, Darleen A Sandoval, Randy J Seeley, Rui B Chang, Stephen D Liberles, David P Olson
Glucagon-like peptide-1 receptor (GLP-1R) agonists are FDA-approved weight loss drugs. Despite their widespread use, the sites of action through which GLP-1R agonists (GLP1RAs) impact appetite and body weight are still not fully understood. Here, we determined whether GLP-1Rs in either GABAergic or glutamatergic neurons are necessary for the acute and chronic effects of the GLP1RA liraglutide on food intake, visceral illness, body weight and neural network activation. We found that mice lacking GLP-1Rs in vGAT -expressing GABAergic neurons responded identically to controls in all parameters measured, whereas deletion of GLP-1Rs in vGlut2 -expressing glutamatergic neurons eliminated liraglutide-induced weight loss and visceral illness and severely attenuated its effects on feeding...
May 18, 2018: Diabetes
https://www.readbyqxmd.com/read/29776440/radiological-pleuroparenchymal-fibroelastosis-associated-to-limited-cutaneous-systemic-sclerosis-a-case-report
#6
D Hassoun, S Dirou, P P Arrigoni, C Durant, M Hamidou, A Néel, C Agard
BACKGROUND: Pleuroparenchymal fibroelastosis (PPFE) is a very rare interstitial lung disease (ILD) characterized by progressive fibrotic lesions of the visceral pleura and the sub-pleural parenchyma, affecting predominantly the upper lobes. PPFE may occur in different contextes like bone marrow or lung transplantations, but also in the context of telomeropathy with mutations of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) or regulator of telomere elongation helicase 1 (RTEL1) genes...
May 18, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29775824/is-urine-a-reliable-clinical-sample-for-the-diagnosis-of-human-visceral-leishmaniasis-a-systematic-review-and-meta-analysis
#7
REVIEW
Shabnam Asfaram, Saeed Hosseini Teshnizi, Mahdi Fakhar, Elham Sadat Banimostafavi, Masoud Soosaraei
Visualization of amastigotes in lymph nodes, bone marrow, and other tissues samples remains the gold standard method for the diagnosis of visceral leishmaniasis (VL) in humans. This gold standard diagnostic method uses a technically challenging microscopy procedure that is often not accessible in many places in the world where VL is endemic. Here, we report the current systematic review and meta-analysis to evaluate whether urine is a reliable clinical sample for diagnosis of human VL. Data were extracted from ten available databases during the period from 2002 to 2017...
May 15, 2018: Parasitology International
https://www.readbyqxmd.com/read/29775657/stabilization-of-the-abdominal-aorta-during-the-cardiac-cycle-with-the-sac-anchoring-nellix-device
#8
Nathan K Itoga, Ga-Young Suh, Christopher P Cheng
The Nellix device utilizes polymer filled endobags to stabilize the abdominal aortic aneurysm (AAA) sac described as endovascular aneurysm sealing (EVAS). We analyzed cardiac gated CTA scans of repaired AAA with EVAS in four patients to evaluate geometry and cardiac pulsatility-induced deformation. Graft translation and aortic curvature changes were found to be minimal during the cardiac cycle. The mean±SD changes in renal-aorta angles (1.0±0.9°) were less than the changes in the SMA-aorta angle (4.0±2...
May 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29775225/cytokines-and-chemokines-differentially-regulate-innate-immune-cell-trafficking-during-post-kala-azar-dermal-leishmaniasis
#9
Ashish K Singh, Vidya N R Das, Ajay Amit, Manas R Dikhit, Vijaya Mahantesh, Shubhankar K Singh, Shyam Naryan, Krishna Pandey, Pradeep Das, Neena Verma, Sanjiva Bimal
Post kala-azar dermal leishmaniasis (PKDL) is often considered to be the anthroponotic reservoir of visceral leishmaniasis (VL) in India. A better understanding of the host immune-response in dermal lesions of PKDL patients is therefore of utmost significance to minimize such patients and to restrict VL transmission. Although the innate immune response is known to play an important role in parasite clearance from dermal lesions, the actual contribution of innate cells to the pathogenicity of PKDL is poorly understood...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29774637/potassium-octatitanate-fibers-induce-persistent-lung-and-pleural-injury-and-are-possibly-carcinogenic-in-male-fischer-344-rats
#10
Mohamed Abdelgied, Ahmed M El-Gazzar, David B Alexander, William T Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hirotsugu Takase, Khaled Abbas Abdou, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Hiroyuki Tsuda, Satoru Takahashi
Potassium octatitanate fibers (K2 O•8TiO2 , POT fibers) are widely used as an alternative to asbestos. We investigated the pulmonary and pleural toxicity of POT fibers with reference to 2 non-fibrous titanium dioxide nanoparticles (nTiO2 ), photo-reactive anatase (a-nTiO2 ) and inert rutile (r-nTiO2 ). Ten-week old male F344 rats were administered 0.5 ml of 250-μg/ml suspensions of POT fibers, a-nTiO2 , or r-nTiO2 , eight times (1 mg/rat) over a 15 day period by trans-tracheal intrapulmonary spraying (TIPS)...
May 17, 2018: Cancer Science
https://www.readbyqxmd.com/read/29774295/serological-investigation-of-visceral-leishmania-infection-in-human-and-its-associated-risk-factors-in-welkait-district-western-tigray-ethiopia
#11
Abrha Bsrat, Mebrahtu Berhe, Endalemaw Gadissa, Habtamu Taddele, Yohannes Tekle, Yohannes Hagos, Adugna Abera, Messele G/Micael, Tehetna Alemayhu, Getachew Gugsa, Abraham Aseffa
Visceral leishmaniasis (VL) is major neglected public health problem in terms of geographical spread and incidence in Ethiopia. Magnitude, public health impact and dynamics of VL were not well studied in Welkait District, Western Tigray, though the area is known for VL. Hence, this study aimed to determine sero-prevalence of human VL and associated risk factors in Welkait as new foci. A cross sectional study design was employed in this study. Two stage stratified random sampling method was used to select study participants...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774290/urbanization-of-human-visceral-leishmaniasis-in-morocco
#12
Kholoud Kahime, Samia Boussaa, Haddou Nhammi, Ali Boumezzough
Human visceral leishmaniasis one of the seven most neglected tropical diseases in the world. In Morocco, HVL is widespread in all regions; but it is more common in the northern part with sporadic cases observed in the South. During the period between 2004 and 2013, the most affected Moroccan provinces were Taounate province, with 220 cases (16.09% of all cases), followed by Chefchaouen with 13.17% and Taza with 10.46% of the total cases. Children < 5 years old are the most affected age group, most cases registered were male...
November 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774181/embolization-with-ethylene-vinyl-alcohol-copolymer-onyx-%C3%A2-for-peripheral-hemostatic-and-non-hemostatic-applications-a-feasibility-and-safety-study
#13
Romaric Né, Olivier Chevallier, Nicolas Falvo, Olivier Facy, Pierre-Emmanuel Berthod, Christophe Galland, Sophie Gehin, Marco Midulla, Romaric Loffroy
Background: Onyx® is a liquid embolic agent, which is approved for the treatment of cerebral vascular lesions but still rarely used in peripheral interventional radiology. The goal of this study is to report the feasibility and safety of embolization with Onyx® for peripheral hemostatic and non-hemostatic endovascular procedures. Methods: Retrospective study of all consecutive patients who underwent visceral or peripheral embolization with Onyx® for hemostatic or non-hemostatic purpose in our department between May 2014 and November 2016...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29773828/single-nucleotide-polymorphisms-in-the-g-protein-coupled-receptor-kinase-5-grk5-gene-are-associated-with-plasma-ldl-cholesterol-levels-in-humans
#14
Stefan Z Lutz, Mathias Falcenberg, Fausto Machicao, Andreas Peter, Martin Kächele, Elko Randrianarisoa, Angela Lehn-Stefan, Robert Wagner, Jürgen Machann, Fritz Schick, Martin Heni, Axel Ullrich, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Konstantinos Kantartzis
Genetically modified mice models suggest an important role for G-protein-coupled receptor kinase 5 (GRK5) in the pathophysiology of obesity and related disorders. We investigated whether single nucleotide polymorphisms (SNPs) in the gene encoding GRK5 affect cardiometabolic traits in humans. We genotyped 3 common SNPs in intron 1 (rs1980030, rs10466210, rs9325562) and one SNP in intron 3 (rs10886471) of GRK5 in 2332 subjects at risk for type 2 diabetes. Total- and visceral fat mass were measured by magnetic resonance (MR) tomography and liver fat content by 1 H-MR spectroscopy...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773765/a-comprehensive-review-on-primary-gallbladder-tuberculosis
#15
Ashish Gupta, Amit Gupta, Rohik Anjum, Saumya Agrawal, Dhiraj Mallik
Tuberculosis (TB) is an infectious disease that can affect any organ system of the body. Abdominal TB can be gastrointestinal, lymph nodal, visceral or peritoneal. The gallbladder (GB) is rarely involved in abdominal TB as a primary organ. Extensive research literature on gallbladder TB is limited to case reports. There has been no review on this rare abdominal pathology. GB tuberculosis is a difficult diagnosis preoperatively. It is a rare differential among the more common gallbladder pathologies such as cholelithiasis, or a gallbladder malignancy...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29773281/-cutaneous-and-systemic-t-cell-lymphoma-treated-with-haploidentical-bone-marrow-transplantation
#16
M Méchineaud, M Mercier, Y Le Corre, A Croué, N Ifrah, L Martin
BACKGROUND: Herein, we report a case of systemic cutaneous T-cell lymphoma refractory to standard therapy, the course of which resulted in haplo-identical bone marrow grafting. PATIENTS AND METHODS: A 53-year-old woman consulted for facial erythema with infiltration, keratotic lesions on the trunk, and adenopathies measuring around 1cm on the axilla and inguinal folds. A diagnosis was made of Sézary syndrome (SS), a leukaemic form of epidermotropic cutaneous T-cell lymphoma...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29773261/perioperative-transfusion-management-in-gastric-cancer-surgery-analysis-of-the-spanish-subset-of-the-eurecca-oesophago-gastric-cancer-registry
#17
Javier Osorio, Carlos Jericó, Coro Miranda, Elisenda Garsot, Alexis Luna, Mónica Miró, Maite Santamaría, Eva Artigau, Joaquín Rodríguez-Santiago, Sandra Castro, Josep Feliu, Aurora Aldeano, Carles Olona, Dulce Momblan, David Ruiz, Gonzalo Galofré, Inmaculada Pros, Xabier García-Albéniz, Miguel Lozano, Manuel Pera
INTRODUCTION: This study evaluated allogenic packed red blood cell (aPRBC) transfusion rates in patients undergoing resection for gastric cancer and the implementation of blood-saving protocols (BSP). METHODS: Retrospective study of all gastric cancer patients operated on with curative intent in Catalonia and Navarra (2011-2013) and included in the Spanish subset of the EURECCA Oesophago-Gastric Cancer Registry. Hospitals with BSP were defined as those with a preoperative haemoglobin (Hb) optimisation circuit associated with restrictive transfusion strategies...
May 14, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29773163/epicardial-adipose-tissue-may-mediate-deleterious-effects-of-obesity-and-inflammation-on-the-myocardium
#18
REVIEW
Milton Packer
Epicardial adipose tissue has unique properties that distinguish it from other depots of visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed microcirculation with the underlying myocardium, and in healthy conditions, produces cytokines that nourish the heart. However, in chronic inflammatory disorders (especially those leading to heart failure with preserved ejection fraction), the epicardium becomes a site of deranged adipogenesis, leading to the secretion of proinflammatory adipokines that can cause atrial and ventricular fibrosis...
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29773145/pathological-and-molecular-characterization-of-systemic-isosporosis-atoxoplasmosis-in-captive-green-winged-saltator-saltator-similis
#19
Ayisa Rodrigues de Oliveira, Tayse Domingues de Souza, Juliana P S Mol, Mayra Cunha Flecher, Emy Hiura, Renato Lima Santos
Systemic isosporosis, also called atoxoplasmosis or visceral coccidiosis, is a disease that affects birds in general. Pathogenesis of systemic isosporosis and its etiologic agent have not been well characterized, but taxonomically Atoxoplasma is currently considered a junior objective synonym of Isospora. The present report aimed to describe pathological and molecular findings of systemic isosporosis in captive green-winged saltators (Saltator similis) from the State of Espírito Santo, Brazil. In a commercial breeding facility eleven birds with two to nine months of age died from 2015 to 2016...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29773132/leishmania-in-wolves-in-northern-spain-a-spreading-zoonosis-evidenced-by-wildlife-sanitary-surveillance
#20
Alvaro Oleaga, Stefania Zanet, Alberto Espí, Marcia Raquel Pegoraro de Macedo, Christian Gortázar, Ezio Ferroglio
Leishmaniosis is, to date, considered the second most important emerging vector-borne protozoal disease in the world after malaria. The form of zoonotic visceral leishmaniosis found in the Mediterranean basin is caused by Leishmania infantum, and its life cycle includes the domestic dog and a phlebotomine sandfly vector. This complex epidemiological cycle and its high prevalence of subclinical infection, hinder the surveillance and control of L. infantum, and allows it to go unnoticed at the geographical endemicity limits of the parasite or in recently colonized areas...
May 15, 2018: Veterinary Parasitology
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