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Lymph node ratio

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https://www.readbyqxmd.com/read/28749115/deregulated-hoxb7-expression-predicts-poor-prognosis-of-patients-with-malignancies-of-digestive-system
#1
Fang-Teng Liu, Han-Min Chen, Ying Xiong, Zheng-Ming Zhu
INTRODUCTION: Numerous studies have investigated the relationship between deregulated HOXB7 expression with the clinical outcome in patients with digestive stem cancers, HOXB7 has showed negative impacts but with varying levels. We aimed to comprehensively evaluate the prediction and prognostic value of HOXB7 in digestive stem cancers. EVIDENCE ACQUISITION: Electronic databases updated to December 1, 2016 were retrieved to collect relevant eligible studies to quantitatively explore the potential roles of HOXB7 as a prognostic indicator in digestive system cancers...
July 26, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28748712/association-between-us-features-of-primary-tumor-and-axillary-lymph-node-metastasis-in-patients-with-clinical-t1-t2n0-breast-cancer
#2
Min Sun Bae, Sung Ui Shin, Sung Eun Song, Han Suk Ryu, Wonshik Han, Woo Kyung Moon
Background Most patients with early-stage breast cancer have clinically negative lymph nodes (LNs). However, 15-20% of patients have axillary nodal metastasis based on the sentinel LN biopsy. Purpose To assess whether ultrasound (US) features of a primary tumor are associated with axillary LN metastasis in patients with clinical T1-T2N0 breast cancer. Material and Methods This retrospective study included 138 consecutive patients (median age = 51 years; age range = 27-78 years) who underwent breast surgery with axillary LN evaluation for clinically node-negative T1-T2 breast cancer...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28748420/risk-factors-for-early-postoperative-small-bowel-obstruction-after-anterior-resection-for-rectal-cancer
#3
Katsuhito Suwa, Takuro Ushigome, Masamichi Ohtsu, Satoshi Narihiro, Shunjin Ryu, Yuya Shimoyama, Tomoyoshi Okamoto, Katsuhiko Yanaga
PURPOSE: The aim of the study was to evaluate risk factors for small bowel obstruction (SBO) in early postoperative period after anterior resection for rectal cancer. METHODS: Patients who underwent anterior resection (AR) [high AR (HAR) or low AR (LAR)] for rectal cancer between January 2009 and April 2016 were enrolled into the study after fulfilling selection criteria. In included patients, risk factors for early postoperative SBO (EPSBO) were analyzed by means of univariate and multivariate analysis...
July 26, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28747578/pathologic-lymph-node-ratio-is-a-predictor-of-esophageal-carcinoma-patient-survival-a-literature-based-pooled-analysis
#4
Yuming Zhao, Shengyi Zhong, Zhenhua Li, Xiaofeng Zhu, Feima Wu, Yanxing Li
The positive lymph node ratio (LNR) has been suggested as a predictor of survival in patients with esophageal carcinoma (EC). However, existed evidences did not completely agree with each other. We sought to examine whether LNR was associated with overall survival (OS). Electronic database was searched for eligible literatures. The primary outcome was the relationship between LNR and OS, which was presented as hazard ratio (HR) with 95% confidence intervals (CIs). All statistical analyses were performed using STATA 11...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747220/a-novel-hand-assisted-laparoscopic-versus-conventional-laparoscopic-right-hemicolectomy-for-right-colon-cancer-study-protocol-for-a-randomized-controlled-trial
#5
Xuyang Yang, Qingbin Wu, Chengwu Jin, Wanbin He, Meng Wang, Tinghan Yang, Mingtian Wei, Xiangbing Deng, Wenjian Meng, Ziqiang Wang
BACKGROUND: Although conventional laparoscopic and hand-assisted laparoscopic surgery for colorectal cancer is widely used today, there remain many technical challenges especially for right colon cancer in obese patients. Herein, we develop a novel hand-assisted laparoscopic surgery (HALS) with complete mesocolic excision (CME), D3 lymphadenectomy, and a total "no-touch" isolation technique (HALS-CME) in right hemicolectomy to overcome these issues. According to previous clinic practice, this novel procedure is not only feasible and safe but has several technical merits...
July 26, 2017: Trials
https://www.readbyqxmd.com/read/28746362/survival-predictors-associated-with-signet-ring-cell-carcinoma-of-the-esophagus-srcce-a-population-based-retrospective-cohort-study
#6
Zihao Wan, Zhihao Huang, Liaobin Chen
PURPOSE: Signet ring cell carcinoma of the esophagus (SRCCE) is an uncommon tumor associated with significant morbidity and mortality. There is still no consensus regarding cut-off values for tumor size, age and optimal treatment for SRCCE. Thus, we elucidated the current survival outcomes of patients with SRCCE and analyzed factors associated with prognosis. METHODS: A retrospective cohort study based on the SEER (The Surveillance, Epidemiology, and End Results) program database was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28743604/clinicopathological-features-management-and-outcome-of-patients-with-poorly-differentiated-oral-and-oropharyngeal-squamous-cell-carcinoma
#7
Zhien Feng, Qiao Shi Xu, Chong Wang, Bo Li, Jin Zhong Li, Ming Hui Mao, Hua Li, Li Zheng Qin, Zhengxue Han
BACKGROUND: The purpose of this study was to explore the clinicopathological features, risk factors, and management of poorly differentiated oral and oropharyngeal squamous cell carcinoma (OOSCC) patients in the northern Chinese population. METHOD: A total of 118 poorly differentiated OOSCC patients from 2236 consecutive cases were retrospectively enrolled in this study. RESULTS: Cox regression analysis showed that site (hazard ratio (HR): 2...
July 4, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28743274/risk-factors-and-a-prediction-model-for-lower-limb-lymphedema-following-lymphadenectomy-in-gynecologic-cancer-a-hospital-based-retrospective-cohort-study
#8
Kenji Kuroda, Yasuhiro Yamamoto, Manami Yanagisawa, Akira Kawata, Naoya Akiba, Kensuke Suzuki, Kazutoshi Naritaka
BACKGROUND: Lower limb lymphedema (LLL) is a chronic and incapacitating condition afflicting patients who undergo lymphadenectomy for gynecologic cancer. This study aimed to identify risk factors for LLL and to develop a prediction model for its occurrence. METHODS: Pelvic lymphadenectomy (PLA) with or without para-aortic lymphadenectomy (PALA) was performed on 366 patients with gynecologic malignancies at Yaizu City Hospital between April 2002 and July 2014; we retrospectively analyzed 264 eligible patients...
July 25, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28742714/impact-of-extracapsular-lymph-node-involvement-after-neoadjuvant-chemoradiation-therapy-followed-by-surgery-in-carcinoma-of-the-esophagus-a-multicenter-study
#9
Lieven P Depypere, Johnny Moons, Christophe Mariette, Xavier B D'Journo, Pascal A Thomas, Arnulf H Hölscher, Elfriede Bollschweiler, Mark I van Berge-Henegouwen, Jan J B Van Lanschot, Toni E M R Lerut, Philippe R Nafteux
OBJECTIVES: The current study aims to examine the impact of extracapsular lymph node involvement (EC-LNI) on survival for both esophageal adenocarcinoma (AC) and squamous cell carcinoma (SCC) treated with neoadjuvant chemoradiation therapy (nCRT) followed by surgery. BACKGROUND: Studies have demonstrated the negative prognostic value of EC-LNI in primary surgery, but its impact after nCRT remains unclear. METHODS: From the databases of 6 European high-volume centers 1505 patients with R0 resections were withheld...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742691/impact-of-lymph-node-yield-on-overall-survival-in-patients-treated-with-neoadjuvant-chemoradiotherapy-followed-by-esophagectomy-for-cancer-a-population-based-cohort-study-in-the-netherlands
#10
Els Visser, Peter S N van Rossum, Jelle P Ruurda, Richard van Hillegersberg
OBJECTIVE: To evaluate the impact of lymph node yield (LNY) on survival in patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy for cancer. BACKGROUND: The value of an extended lymphadenectomy after nCRT for esophageal cancer is debated. Recent reports demonstrate no association between LNY and survival. This association has not yet been evaluated in larger cohorts. METHODS: All patients who underwent nCRT followed by esophagectomy between 2005 and 2014 were identified from the Netherlands Cancer Registry...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742156/ct-pattern-analysis-of-necrotizing-and-nonnecrotizing-lymph-nodes-in-kikuchi-disease
#11
Eun Jung Shim, Kyung Mi Lee, Eui Jong Kim, Hyug-Gi Kim, Ji Hye Jang
OBJECTIVE: The purpose of this study was to determine whether a CT interpretation with imaging pattern analysis differentiates Kikuchi disease (KD) from the two more frequently encountered differential lymph nodes diagnoses of tuberculous lymphadenopathy (TL) and reactive hyperplasia (RH). MATERIALS AND METHODS: Between January 2012 and July 2015, 20 patients with KD (6 men, 14 women; mean age, 27.80 years), 36 patients with RH (10 men, 26 women; mean age, 33.08 years) and 34 patients with TL (17 men, 17 women; mean age, 39...
2017: PloS One
https://www.readbyqxmd.com/read/28741199/radioactive-iodine-ablation-decrease-recurrences-in-papillary-thyroid-microcarcinoma-with-lateral-lymph-node-metastasis-in-chinese-patients
#12
Shuai Xue, Peisong Wang, Jia Liu, Guang Chen
INTRODUCTION: We aimed to carry out a retrospective study from a single institution to determine whether radioactive iodine (RAI) ablation decreases the risk of recurrence of papillary thyroid microcarcinoma (PTMC) patients that presented with lateral lymph node metastasis (LLNM). METHODS: We retrospectively analyzed a total of 6361 consecutive PTMC patients who initially underwent surgery for the treatment of thyroid carcinoma at the First Hospital of Jilin University, between January 2005 and February 2015...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28740920/pathologic-response-after-neoadjuvant-chemotherapy-predicts-locoregional-control-in-patients-with-triple-negative-breast-cancer
#13
Victor E Chen, Erin F Gillespie, Kaveh Zakeri, James D Murphy, Catheryn M Yashar, Sharon Lu, John P Einck
PURPOSE: Our goal was to determine the impact of pathologic response after neoadjuvant chemotherapy in triple negative breast cancer (TNBC) on the subsequent risk of locoregional recurrence (LRR) and disease-free survival (DFS) in the setting of adjuvant radiation therapy. METHODS AND MATERIALS: This was an institutional review board-approved retrospective chart review of patients with clinical stage I-III breast cancer treated with neoadjuvant chemotherapy, local surgery (breast conservation or mastectomy), and adjuvant radiation therapy between 1997 and 2015...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740666/the-value-of-positive-lymph-nodes-ratio-combined-with-negative-lymph-node-count-in-prediction-of-breast-cancer-survival
#14
Jing Yang, Quanyi Long, Hongjiang Li, Qing Lv, Qiuwen Tan, Xiaoqin Yang
BACKGROUND: Positive lymph node ratio (LNR), defined as ratio of positive lymph nodes to all lymph nodes removed, is a powerful prognostic factor in invasive breast cancer. Here we focused on the impact of negative lymph node (NLN) count on the prediction of value of LNR in breast cancer survival. METHODS: Of 929 invasive breast cancer patients were enrolled in our retrospective study. We use Kaplan-Meier to calculate the 5-year overall survival (OS) according to different clinicopathologic parameters...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740506/comparison-of-inflammation-based-prognostic-scores-in-a-cohort-of-patients-with-resectable-esophageal-cancer
#15
G Jomrich, M Paireder, A Gleiss, I Kristo, L Harpain, S F Schoppmann
BACKGROUND: A number of studies have revealed that inflammation-based prognostic scores, such as Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS), and C-reactive protein and albumin ratio (C/A ratio), are associated with poor outcome in cancer patients. However, until now, no study has investigated the role of these prognostic scores in a cohort of neoadjuvant-treated esophageal adenocarcinomas (nEAC) and squamous cell carcinomas (nESCC). METHODS: Patients had laboratory measurements within three days before resection...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28740401/the-diagnostic-and-prognostic-values-of-ki-67-mib-1-expression-in-thyroid-cancer-a-meta-analysis-with-6-051-cases
#16
REVIEW
Deng-Hua Pan, Dong-Yue Wen, Yi-Huan Luo, Gang Chen, Hong Yang, Jun-Qiang Chen, Yun He
BACKGROUND: Growing evidence has demonstrated that Ki-67/MIB-1 has an effect on the clinical progression and prognosis in cancers. However, the diagnostic and prognostic values of Ki-67/MIB-1 in thyroid cancer remain unclear. MATERIALS AND METHODS: The meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were retrieved from PubMed, EBSCO, EMBASE, ISI Web of Science, China National Knowledge Infrastructure, WanFang and Chinese VIP databases...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28739763/exploration-of-the-radiotherapeutic-clinical-target-volume-delineation-for-gastric-cancer-from-lymph-node-metastases
#17
Wei Dong, Baosheng Li, Juan Wang, Yipeng Song, Zicheng Zhang, Chengrui Fu
AIM: To clarify the clinical target volume of regional lymph nodes (CTVn) delineation of gastric adenocarcinoma. MATERIALS AND METHODS: The pattern of lymph node metastases (LNM) of a total of 1,473 patients with gastric cancer (GC) who had undergone gastrectomy and lymphadenectomy with more than 15 lymph nodes retrieved was retrospectively examined. RESULTS: A univariate analysis showed that T stage (p<0.001), macroscopic type (p=0.001), tumor differentiation (p<0...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739755/nomogram-model-of-lnr-predicts-survival-in-premenopausal-patients-with-node-positive-luminal-breast-cancer
#18
Tao Qin, Yin-Duo Zeng, Qianyi Lu, Xinke Zhang, G E Qin, Qiufan Zheng, Fei Xu, Roujun Peng, Zhongyu Yuan, Shusen Wang
AIM: The aim of this study was to assess the prognostic value of lymph node ratio (LNR) in premenopausal patients with luminal breast carcinoma. MATERIALS AND METHODS: A total of 885 female patients who presented with axillary lymph node-positive luminal breast cancer between 2000 and 2009 were investigated. Using X-tile, we classified patients into low-, intermediate- and high-risk groups based on LNR. The Kaplan-Meier method was used to determine cumulative survival curves...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738955/primary-site-predicts-grade-for-gastroenteropancreatic-neuroendocrine-tumors
#19
Timothy L Fitzgerald, Catalina Mosquera, C Suzanne Lea, Matthew McMullen
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and abstruse neoplasms with increasing incidence and clinical relevance. The National Cancer Data Base was examined to identify GEP-NET cases from 2004 to 2013. In total, 39,454 patients diagnosed with GEP-NET were identified. Median age was 61 years. Majority was female (50.13%), white (79.49%), and had low-grade neoplasms (84.39%). On univariate analysis, age, sex, race, primary site, tumor size, and regional lymph node involvement were associated with tumor grade (P < 0...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28736640/systematic-review-and-a-meta-analysis-of-hospital-and-surgeon-volume-outcome-relationships-in-colorectal-cancer-surgery
#20
Ya Ruth Huo, Kevin Phan, David L Morris, Winston Liauw
BACKGROUND: Numerous hospitals worldwide are considering setting minimum volume standards for colorectal surgery. This study aims to examine the association between hospital and surgeon volume on outcomes for colorectal surgery. METHODS: Two investigators independently reviewed six databases from inception to May 2016 for articles that reported outcomes according to hospital and/or surgeon volume. Eligible studies included those in which assessed the association hospital or surgeon volume with outcomes for the surgical treatment of colon and/or rectal cancer...
June 2017: Journal of Gastrointestinal Oncology
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