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https://www.readbyqxmd.com/read/29792851/collagen-induced-arthritis-in-dark-agouti-rats-as-a-model-for-study-of-immunological-sexual-dimorphisms-in-the-human-disease
#1
Mirjana Dimitrijević, Nevena Arsenović-Ranin, Biljana Bufan, Mirjana Nacka-Aleksić, Mirjana Lazarević Macanović, Petar Milovanović, Marija Đurić, Jelena Sopta, Gordana Leposavić
Collagen-induced arthritis (CIA) is a frequently used animal model of rheumatoid arthritis, human autoimmune disease that exhibits clear sex bias in incidence and clinical course. Female Dark Agouti rats immunized for CIA showed also greater incidence and higher arthritic score than their male counterparts. The study investigated sex differences in mechanisms controlling the primary immune responses in draining lymph nodes (dLNs), as a factor contributing to this dimorphism. The higher frequencies of CD4 + CD25 + Foxp3- cells, presumably activated effector T (Teff) cells, and IL-17+, IFN-γ + and IL-17 + IFN-γ + T cells were found in female comapared with male rat dLNs...
May 21, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29791289/minimally-invasive-lung-cancer-surgery-performed-by-thoracic-surgeons-as-effective-as-thoracotomy
#2
Daniel J Boffa, Andrzej S Kosinski, Anthony P Furnary, Sunghee Kim, Mark W Onaitis, Betty C Tong, Patricia A Cowper, Jessica R Hoag, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam, Felix G Fernandez
Purpose The prevalence of minimally invasive lung cancer surgery using video-assisted thoracic surgery (VATS) has increased dramatically over the past decade, yet recent studies have suggested that the lymph node evaluation during VATS lobectomy is inadequate. We hypothesized that the minimally invasive approach to lobectomy for stage I lung cancer resulted in a longitudinal outcome that was not inferior to thoracotomy. Patients and Methods Patients > 65 years of age who had undergone lobectomy for stage I lung cancer between 2002 and 2013 were analyzed within the Society of Thoracic Surgeons General Thoracic Surgery Database, which had been linked to Medicare data, as part of a retrospective-cohort, noninferiority study...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29790693/hounsfield-units-from-unenhanced-18f-fdg-pet-ct-are-useful-in-evaluating-supradiaphragmatic-lymph-nodes-in-children-and-adolescents-with-classical-hodgkin-s-lymphoma
#3
Radosław Chaber, Mateusz Łasecki, Justyna Kwaśnicka, Kornelia Łach, Zbigniew Podgajny, Cyprian Olchowy, Urszula Zaleska-Dorobisz
BACKGROUND: The precise identification of the primarily-affected nodal regions in Hodgkin's lymphoma(HL) is essential in determining the stage of the disease and the intensity of chemotherapy and radiotherapy. OBJECTIVES: The aim of this study was to use the degree of X-ray attenuation (XRA) in Hounsfield units(HU) and the lymph node-to-muscle attenuation ratio (LN/M) in computed tomography (CT) unenhancedimaging, routinely performed with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET),to distinguish HL-affected supradiaphragmatic lymph nodes...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29788392/prognostic-accuracy-of-different-lymph-node-staging-systems-in-rectal-adenocarcinoma-with-or-without-preoperative-radiation-therapy
#4
Feng Shen, Junhui Cui, Ke Cai, Haiqiang Pan, Heqi Bu, Feng Yu
Background and objective: A variety of different lymph node (LN) staging systems have been developed to describe the lymph node status accurately. We aim to compare the prognostic accuracy of American Joint Committee on Cancer seventh N stage relative to negative number of lymph node (nLN), lymph node ratio (LNR) and log odds of metastatic lymph nodes (LODDS) in rectal adenocarcinoma (RC). Methods: A total of 19 167 Stage II-III rectal cancer patients who underwent surgical resection of rectal adenocarcinoma were identified from Surveillance, Epidemiology and End Results database...
May 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29788053/reversing-ongoing-chronic-intestinal-inflammation-and-fibrosis-by-sustained-block-of-il-12-and-il-23-using-a-vaccine-in-mice
#5
Qingdong Guan, Carolyn R Weiss, Shuhe Wang, Gefei Qing, Xi Yang, Richard J Warrington, Charles N Bernstein, Zhikang Peng
Interleukin (IL)-12 and IL-23 that share subunit p40 are important cytokines in the pathogenesis of inflammatory bowel disease. We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene sulfonic acid (TNBS)-induced murine colitis model. Here, we evaluated whether administration of the vaccine after establishment of colitis would be effective in modifying both TNBS-induced and dextran sulfate sodium (DSS)-induced chronic colitis and the underlying immune mechanisms...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29785019/cribriform-morular-variant-of-thyroid-carcinoma-a-neoplasm-with-distinctive-phenotype-associated-with-the-activation-of-the-wnt-%C3%AE-catenin-pathway
#6
REVIEW
José Manuel Cameselle-Teijeiro, Diego Peteiro-González, Javier Caneiro-Gómez, María Sánchez-Ares, Ihab Abdulkader, Catarina Eloy, Miguel Melo, Isabel Amendoeira, Paula Soares, Manuel Sobrinho-Simões
Cribriform-morular variant of thyroid carcinoma is classically associated with familial adenomatous polyposis but, it can also occur as a sporadic neoplasm. This neoplasm is much more frequently observed in women than in men (ratio of 61:1). In familial adenomatous polyposis patients, tumors are generally multifocal and/or bilateral (multinodular appearance), whereas in the sporadic cases tumors tend to occur as single nodules. The tumors are well delimited, and characteristically show a blending of follicular, cribriform, papillary, trabecular, solid, and morular patterns...
May 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29782362/breast-conservation-therapy-after-neoadjuvant-chemotherapy-does-not-compromise-10-year-breast-cancer-specific-mortality
#7
Renee L Arlow, Lisa E Paddock, Xiaoling Niu, Laurie Kirstein, Bruce G Haffty, Sharad Goyal, Thomas Kearney, Deborah Toppmeyer, Antoinette M Stroup, Atif J Khan
OBJECTIVES: Neoadjuvant chemotherapy can increase the rate of breast-conserving surgery by downstaging disease in patients with breast cancer. The aim of this study was to determine whether patients who received neoadjuvant chemotherapy have equal survival after breast-conservation therapy compared with mastectomy. MATERIAL AND METHODS: Using the New Jersey State Cancer Registry (NJSCR) patients with a primary breast cancer diagnosed between 1998 and 2003 who underwent neoadjuvant chemotherapy were selected (n=1,468)...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29779936/early-response-assessment-on-mid-treatment-computed-tomography-predicts-for-locoregional-recurrence-in-oropharyngeal-cancer-patients-treated-with-definitive-radiation-therapy
#8
Rafi Kabarriti, N Patrik Brodin, George Lundgren, Nitin Ohri, Wolfgang A Tomé, Shalom Kalnicki, Madhur K Garg
PURPOSE: To evaluate whether a response assessment using mid-treatment computed tomography (CT) scans during definitive radiation therapy (RT) for oropharyngeal head and neck cancer can predict for locoregional recurrence (LRR). METHODS AND MATERIALS: Head and neck cancer patients who receive RT at our institution undergo CT repeat scans at the 15th fraction, with treatment replanning in the case of an inadequate dose to gross disease or an increased dose to organs at risk...
April 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29779309/-the-survival-prediction-model-of-advanced-gallbladder-cancer-based-on-bayesian-network-a-multi-institutional-study
#9
Z H Tang, Z M Geng, C Chen, S B Si, Z Q Cai, T Q Song, P Gong, L Jiang, Y H Qiu, Y He, W L Zhai, S P Li, Y C Zhang, Y Yang
Objective: To investigate the clinical value of Bayesian network in predicting survival of patients with advanced gallbladder cancer(GBC)who underwent curative intent surgery. Methods: The clinical data of patients with advanced GBC who underwent curative intent surgery in 9 institutions from January 2010 to December 2015 were analyzed retrospectively.A median survival time model based on a tree augmented naïve Bayes algorithm was established by Bayesia Lab software.The survival time, number of metastatic lymph nodes(NMLN), T stage, pathological grade, margin, jaundice, liver invasion, age, sex and tumor morphology were included in this model...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29778540/the-clinicopathological-and-prognostic-value-of-long-non-coding-rna-zeb1-as1-in-solid-tumors-a-meta-analysis
#10
REVIEW
Chaojie Liang, Jing Liu, Hua Ge, Yingchen Xu, Guangming Li, Jixiang Wu
BACKGROUND AND AIM: Studies have reported that Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) is overexpressed in many malignant tumors. However, the sample size in those studies was limited, so the clinicopathological and prognostic value of ZEB1-AS1 in solid tumors remains undetermined, Accordingly, the aim of this meta-analysis was to evaluate the relationship between the expression of lncRNA ZEB1-AS1 and clinicopathological characteristics and prognosis in patients with solid tumors...
May 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29777564/the-importance-of-non-regional-lymph-nodes-in-assigning-risk-in-primary-metastatic-prostate-cancer
#11
Adnan Ali, Alexander Hoyle, Hitesh Mistry, Noel W Clarke
OBJECTIVE: To determine the prognostic relevance of non-regional lymph nodes (NRLN) metastases presenting synchronously with bone metastases in metastatic prostate cancer (mPCa) for guiding treatment decisions based on oligometastatic definitions. PATIENTS AND METHODS: Patients diagnosed with mPCa between 2004 and 2013 were identified from the surveillance, epidemiology and end-results (SEER) database and were grouped by metastatic sites into only NRLN, only bone, bone + NRLN and other sites ± bone/NRLN metastases...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29774941/-meta-analysis-of-gastric-stump-cancer-after-gastrectomy-for-gastric-cancer
#12
Yongbai Li, Zhidong Gao, Xuesong Zhao, Bo Wang, Yingjiang Ye, Shan Wang, Kewei Jiang
OBJECTIVE: To study the clinicopathological features and prognosis of gastric stump cancer (GSC) following subtotal gastrectomy for gastric cancer, to compare the clinicopathologic differences between narrow GSC and generalized GSC, and to compare the prognosis between GSC and primary proximal gastric cancer (PPGC) after radical resection. METHODS: Literatures of GSC-associated clinical study were searched by computer from the Cochrane Library, Medline, PubMed, CNKI, Wanfang and VIP databases, and the retrieval period was from the establishment of database to December 31, 2017...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774933/-clinicopathological-characteristics-and-prognostic-factor-analysis-of-carcinoma-in-remnant-stomach-cancer-at-peking-university-cancer-hospital
#13
Yinkui Wang, Ziyu Li, Chenggen Jin, Xiangji Ying, Chao Gao, Yuchen Wang, Qiyan Xiao, Yan Zhang, Yufan Chen, Lianhai Zhang, Jiafu Ji
OBJECTIVE: To investigate the interval time to canceration, clinicopathological characteristics and prognostic factors of carcinoma in remnant stomach (CRS) in patients with primary benign diseases or primary malignant tumors. METHODS: Based on the criteria of the definition of CRS proposed by Japanese Gastric Cancer Association in 2017, a retrospective analysis was conducted on clinicopathological characteristics of patients diagnosed with CRS at Peking University Cancer Hospital from March 1992 to March 2017...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774932/-pathological-staging-criteria-for-carcinoma-in-the-remnant-stomach-an-exploratory-study
#14
Zhidong Gao, Xuesong Zhao, Kewei Jiang, Bo Wang, Yongbai Li, Yingjiang Ye, Shan Wang
OBJECTIVE: To explore the prognostic value of the tumor-ratio-metastasis (TRM) staging system for carcinoma in the remnant stomach(CRS). METHODS: Clinicopathological data of 91 CRS patients who underwent surgery at Peking University People's Hospital between March 1992 and December 2017 were retrospectively analyzed. According to the ratio of metastatic lymph node to dissected lymph node, the R staging was obtained, and the pN staging was replaced by the R staging to create the TRM staging...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29770847/the-investigation-of-the-survival-time-after-recurrence-in-patients-with-pancreatic-ductal-adenocarcinoma-for-individualization-of-adjuvant-chemotherapy
#15
Daisaku Yamada, Hidetoshi Eguchi, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Masaki Mori, Yuichiro Doki
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; however, the frequency of recurrence can be reduced if curative surgery following adjuvant chemotherapy is applied. At present, adjuvant chemotherapy is uniformly performed in all patients, as it is unclear which tumor types are controlled best or worst. We investigated patients with recurrence to establish the optimum treatment strategy. METHODS: Of 138 patients who underwent curative surgery for PDAC, 85 developed recurrence...
May 17, 2018: Surgery Today
https://www.readbyqxmd.com/read/29770631/comparison-between-adjuvant-chemotherapy-and-adjuvant-radiotherapy-chemoradiotherapy-after-radical-surgery-in-patients-with-cervical-cancer-a-meta-analysis
#16
Kwang Beom Lee, Seung Hyuk Shim, Jong Min Lee
OBJECTIVE: To estimate the effect of adjuvant chemotherapy (AC) on the prognosis in cervical cancer patients with intermediate- or high-risk factors after radical hysterectomy (RH) compared to that for adjuvant radiotherapy (AR). METHODS: The Embase and MEDLINE databases and the Cochrane Library were searched for published studies comparing cervical cancer patients who received AC with those who received AR after RH. The endpoints were patient oncologic outcome...
April 16, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770619/impact-of-lymph-node-ratio-on-survival-in-stage-iiic-endometrioid-endometrial-cancer-a-turkish-gynecologic-oncology-group-study
#17
Ali Ayhan, Nazlı Topfedaisi Ozkan, Murat Öz, Günsu Kimyon Comert, Zeliha Firat Cuylan, Gonca Çoban, Osman Turkmen, Baki Erdem, Hanifi Şahin, Özgür Akbayır, Murat Dede, Ahmet Taner Turan, Husnu Celik, Tayfun Güngör, Ali Haberal, Macit Arvas, Mehmet Mutlu Meydanli
OBJECTIVE: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in women with stage IIIC endometrioid endometrial cancer (EC). METHODS: A multicenter, retrospective department database review was performed to identify patients with stage IIIC pure endometrioid EC at 6 gynecologic oncology centers in Turkey. A total of 207 women were included. LNR, defined as the percentage of positive lymph nodes (LNs) to total nodes recovered, was stratified into 2 groups: LNR1 (≤0...
March 13, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29766456/prognostic-role-for-the-derived-neutrophil-to-lymphocyte-ratio-in-early-breast-cancer-a-geicam-9906-substudy
#18
A J Templeton, Á Rodríguez-Lescure, A Ruíz, E Alba, L Calvo, M Ruíz-Borrego, A Santaballa, C A Rodríguez, C Crespo, M Ramos, J M Gracia-Marco, A Lluch, I Álvarez, M I Casas, M Sánchez-Aragó, R Caballero, E Carrasco, E Amir, M Martin, A Ocaña
PURPOSE: Elevated markers of host inflammation, a hallmark of cancer, have been associated with worse outcomes in several solid tumors. Here, we explore the prognostic role of the derived neutrophil-to-lymphocyte ratio (dNLR), across different tumor subtypes, in patients with early breast cancer. PATIENTS AND METHODS: This was a retrospective analysis of 1246 patients with lymph node-positive, operable early breast cancer enrolled in the GEICAM/9906 trial, a multicenter randomized phase 3 study evaluating adjuvant chemotherapy...
May 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29765527/lpmab-23-recognizing-cancer-type-podoplanin-is-a-novel-predictor-for-a-poor-prognosis-of-early-stage-tongue-cancer
#19
Akihiro Miyazaki, Hiromi Nakai, Tomoko Sonoda, Yoshihiko Hirohashi, Mika K Kaneko, Yukinari Kato, Yoshihiko Sawa, Hiroyoshi Hiratsuka
Purpose: We report that the reactivity of a novel monoclonal antibody LpMab-23 for human cancer-type podoplanin (PDPN) is a predictor for a poor prognosis of tongue cancer. Patients and Methods: The association between LpMab-23-recognizing cancer-type PDPN expression and clinical/pathological features were analyzed on 60 patients with stage I and II tongue cancer treated with transoral resection of the primary tumor. Results: In the mode of invasion, the LpMab-23-dull/negative cases were significantly larger in cases with low-grade malignancies and without late cervical lymph node metastasis, than in cases with high-grade malignancies and the metastasis...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765332/galectin-9-expression-predicts-favorable-clinical-outcome-in-solid-tumors-a-systematic-review-and-meta-analysis
#20
Xiaoxiang Zhou, Lejia Sun, Dan Jing, Gang Xu, Jinmei Zhang, Li Lin, Jingjing Zhao, Zhuoran Yao, Hongfeng Lin
Background and Objective: Galectin-9 (Gal-9) is one of the galectin family members which are known as proteins with β-galactoside-binding affinity. Accumulative evidence suggest that Gal-9 plays multifaceted roles in tumor biology. However, the prognostic significance of Gal-9 in solid cancer patients remains controversial. The objective of the study was to clarify the prognostic significance of Gal-9 in solid tumors via meta-analysis. Methods: We searched PubMed, Embase and the Cochrane library for studies that report the correlation between Gal-9 expression and prognosis or clinicopathological parameters in solid cancer patients from inception to October 2017, with no language restriction...
2018: Frontiers in Physiology
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