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Lymph node ratio

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https://www.readbyqxmd.com/read/28215039/impact-of-surgical-experience-on-management-and-outcome-of-pancreatic-surgery-performed-in-high-and-low-volume-centers
#1
Marco Stella, Massimiliano Bissolati, Daniele Gentile, Alessandro Arriciati
Pancreaticoduodenectomy (PD) is one of the procedures in general surgery with the highest rate of life-threatening complications. The positive impact of the volume-outcome ratio on outcomes and mortality in pancreatic surgery (PS) has led to policy-level efforts toward centralization of care for PS that is currently under evaluation by some Regional Health Services. The role of the surgeon's experience and training is still under debate. The aim of this paper is to compare the outcomes of PS by the same surgeon in a high volume (HV) and in a low volume (LV) hospital to assess whether a specific training in PS could outdo the benefits of hospital volume...
February 18, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28214659/clinical-outcomes-and-prognostic-factors-of-patients-with-advanced-mesothelioma-treated-in-a-phase-i-clinical-trials-unit
#2
Dionysis Papadatos-Pastos, Desam Roda, Maria Jose De Miguel Luken, Ann Petruckevitch, Awais Jalil, Marta Capelan, Vasiliki Michalarea, Joao Lima, Nikolaos Diamantis, Jaishree Bhosle, L Rhoda Molife, Udai Banerji, Johann S de Bono, Sanjay Popat, Mary E R O'Brien, Timothy A Yap
BACKGROUND: We have previously reported a prognostic score for patients in phase I trials in the Drug Development Unit, treated at the Royal Marsden Hospital (RPS). The RPS is an objective tool used in patient selection for phase I trials based on albumin, number of disease sites and LDH. Patients with mesothelioma are often selected for phase I trials as the disease remains localised for long periods of time. We have now reviewed the clinical outcomes of patients with relapsed malignant mesothelioma (MM) and propose a specific mesothelioma prognostic score (m-RPS) that can help identify patients who are most likely to benefit from early referral...
February 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28213790/optical-see-through-cancer-vision-goggles-enable-direct-patient-visualization-and-real-time-fluorescence-guided-oncologic-surgery
#3
Suman B Mondal, Shengkui Gao, Nan Zhu, LeMoyne Habimana-Griffin, Walter J Akers, Rongguang Liang, Viktor Gruev, Julie Margenthaler, Samuel Achilefu
BACKGROUND: The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. METHODS: We evaluated an optical see-through goggle augmented imaging and navigation system (GAINS) for near-infrared, fluorescence-guided surgery. Tumor-bearing mice injected with a near infrared cancer-targeting agent underwent fluorescence-guided, tumor resection...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28212778/the-prognostic-value-of-lymph-node-ratio-and-log-odds-of-positive-lymph-nodes-in-patients-with-lung-adenocarcinoma
#4
Yue Zhao, Guodong Li, Difan Zheng, Ming Jia, Weixing Dai, Yihua Sun, Haiquan Chen
OBJECTIVE: To investigate whether lymph node ratio and log odds ratio can be used for predicting the prognosis of patients with lung adenocarcinoma. METHODS: A total of 1097 patients with lung adenocarcinoma who underwent complete surgical resection and systematic lymph node dissection between 2008 and 2013 were studied retrospectively. Lymph node ratio was calculated as: positive lymph nodes total lymph nodes . Log odds ratio was calculated as: logpositivelymph nodes+0...
March 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28212549/the-prevalence-and-clinicopathological-features-of-breast-cancer-patients-with-hepatitis-b-virus-infection-in-china
#5
He Wu, Chunxia Zhao, Vishnu Prasad Adhikari, Linjie Lu, Jianbo Huang, Yuxian Wei, Qingqing Luo, Wei Dai, Yutuan Wu, Xin Li, Kainan Wu, Ling-Quan Kong
We performed a case-control study to investigate the prevalence and clinicopathological features of breast cancer patients with hepatitis B virus (HBV) infection in China. The clinical data for 2,796 female patients with newly diagnosed, primary breast cancer were evaluated. A total of 234 breast cancer patients with HBV infection (the case group; positive for hepatitis B surface antigen [HBsAg]) and 444 breast cancer patients without HBV infection (the control group; negative for HBsAg, hepatitis B surface antibody, hepatitis B envelope antigen, hepatitis B envelope antibody, and hepatitis B core antibody) were selected for study...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212256/hepatic-epithelioid-hemangioendothelioma-and-adult-liver-transplantation-proposal-for-a-prognostic-score-based-on-the-analysis-of-the-eltr-elita-registry
#6
Quirino Lai, Estelle Feys, Vincent Karam, Rene Adam, Jurgen Klempnauer, Martin Oliverius, Vincenzo Mazzaferro, Andreas Pascher, Piotr Remiszewski, Helena Isoniemi, Jacques Pirenne, Aksel Foss, Bo G Ericzon, Sasa Markovic, Jan P Lerut
BACKGROUND: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare vascular tumor which has an intermediate aggressive behavior. Although the value of liver transplantation (LT) is well established, its place in the management of HEHE is still unclear. The aim of this study is to confirm, based on a very large patient cohort, the value of LT in the management of HEHE and to identify risk factors for post-LT recurrence. METHODS: The outcome of 149 transplant recipients with HEHE recorded in the European Liver Transplant Registry during the period November 1984 to May 2014 was analyzed...
March 2017: Transplantation
https://www.readbyqxmd.com/read/28211504/novel-preoperative-nomogram-for-prediction-of-futile-resection-in-patients-undergoing-exploration-for-potentially-resectable-intrahepatic-cholangiocarcinoma
#7
Kwangwoo Nam, Dae Wook Hwang, Ju Hyun Shim, Tae Jun Song, Sang Soo Lee, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim, Ki-Hun Kim, Shin Hwang, Kwang-Min Park, Young-Joo Lee, Minkyu Han, Do Hyun Park
Surgical resection is the treatment of choice for intrahepatic cholangiocarcinoma (IHCC). However, discrepancies between preoperative workup and intraoperative findings can occur, resulting in unexpected and unfavorable surgical outcomes. The aim of this study was to develop a feasible preoperative nomogram to predict futile resection of IHCC. A total of 718 patients who underwent curative-intent surgery for IHCC between January 2005 and December 2014 were included. The patients were divided into a training cohort (2005-2010, n = 377) and validation cohort (2011-2014, n = 341)...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210088/clinicopathological-treatment-and-prognosis-study-of-43-gastric-neuroendocrine-carcinomas
#8
De-Jun Liu, Xue-Liang Fu, Wei Liu, Lu-Ying Zheng, Jun-Feng Zhang, Yan-Miao Huo, Jiao Li, Rong Hua, Qiang Liu, Yong-Wei Sun
AIM: To provide more information and therapeutic methods about gastric neuroendocrine carcinomas (G-NECs) which occur rarely but are highly malignant and clinically challenging. METHODS: We retrospectively analyzed the clinicopathological characteristics, treatments, and prognosis of 43 G-NEC patients at our hospital between January 2007 and December 2014. The diagnosis was based on the 2010 World Health Organization criteria. RESULTS: Forty-three G-NECs containing 39 small cell carcinomas and 4 large cell NECs with Ki67 > 60% were included in this study, accounting for only 0...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28205002/prognostic-impacts-of-postoperative-complications-in-patients-with-intrahepatic-cholangiocarcinoma-after-curative-operations
#9
Tatsunori Miyata, Yo-Ichi Yamashita, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kensuke Yamamura, Kota Arima, Takayoshi Kaida, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
BACKGROUND: The postoperative complication is one of an indicator of poor prognosis in patients with several gastroenterological cancers after curative operations. We, herein, examined prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations. METHODS: We retrospectively analyzed 60 patients with intrahepatic cholangiocarcinoma who underwent primary curative operations from June 2002 to February 2016...
February 15, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28203421/clinical-significance-of-preoperative-carcinoembryonic-antigen-level-in-patients-with-clinical-stage-ia-non-small-cell-lung-cancer
#10
Ryo Maeda, Takashi Suda, Ayumi Hachimaru, Daisuke Tochii, Sachiko Tochii, Yasushi Takagi
BACKGROUND: The objective of this study was to assess the preoperative serum carcinoembryonic antigen (CEA) level in patients with clinical stage IA non-small cell lung cancer (NSCLC) and to evaluate its clinical significance. METHODS: Between January 2005 and December 2014, a total of 378 patients with clinical stage IA NSCLC underwent complete resection with systematic node dissection. The survival rate was estimated starting from the date of surgery to the date of either death or the last follow-up by the Kaplan-Meier method...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28199988/clinicopathologic-and-prognostic-significance-of-human-epidermal-growth-factor-receptor-in-patients-with-gastric-cancer-an-update-meta-analysis
#11
Zhiqiao Zhang, Hongfeng Tang, Jixin Lin, Yunzhao Hu, Guanying Luo, Zhaowen Luo, Canchang Cheng, Peng Wang
PURPOSE: The aim of this update meta-analysis was to clarify the clinicopathologic and prognostic significance of human epidermal growth factor receptor(EGFR) expression in gastric cancer patients. EXPERIMENTAL DESIGN: Several electronic databases were searched from January 1970 to May 2016. The odds ratio (OR) was calculated to assess the association between EGFR expression and pathological parameters. The hazard ratio (HR) and 95% CI were calculated to explore the relationship between EGFR expression and overall survival...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28199963/long-non-coding-rna-hulc-as-a-potential-prognostic-biomarker-in-human-cancers-a-meta-analysis
#12
Yang-Hua Fan, Miao-Jing Wu, Yuan Jiang, Minhua Ye, Shi-Gang Lu, Lei Wu, Xin-Gen Zhu
Since the long non-coding RNA HULC (Highly Upregulated in Liver Cancer) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors. We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from inception until August 14, 2016 and identified seven studies with 730 cancer patients for the meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between HULC expression and overall survival (OS)...
February 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28199962/incorporation-of-the-number-of-positive-lymph-nodes-leads-to-better-prognostic-discrimination-of-node-positive-early-stage-cervical-cancer
#13
Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Xu-Lin Liao, Feng-Yan Li, Huan-Xin Lin, Li-Chao Yang, Zhen-Yu He
To determine the prognostic value of the number of positive lymph nodes (LNs) in cervical cancer and further stratify patients with positive LNs into multiple risk groups based on analysis of Surveillance Epidemiology and End Results (SEER) program. Patients with cervical cancer who undergo hysterectomy and had pathologically-confirmed positive LNs after lymphadenectomy were identified using the SEER database (1988-2012). Kaplan-Meier survival methods and Cox proportional hazards regression were performed. We included 2,222 patients with the median number of removed LNs and positive LNs was 22 and 2, respectively...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28199747/outcomes-in-patients-with-early-stage-breast-cancer-who-underwent-a-21-gene-expression-assay
#14
Carlos H Barcenas, Akshara Raghavendra, Arup K Sinha, Masood Pasha Syed, Limin Hsu, Modesto G Patangan, Mariana Chavez-MacGregor, Yu Shen, Gabriel H Hortobagyi, Vicente Valero, Sharon H Giordano, Naoto T Ueno, Debu Tripathy
BACKGROUND: Invasive disease-free survival (IDFS) rates are excellent in patients with breast cancer (BC) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), axillary lymph node-negative (LN-) tumors with a 21-gene expression assay recurrence score (RS) of 0 to 10. However, to the authors' knowledge, the outcomes among patients with an RS of 11 to 25 who are treated with endocrine therapy alone are unknown. METHODS: In this retrospective single-institution study, the authors described the characteristics of patients with HR+, HER2-, LN- BC who underwent a 21-gene expression assay...
February 15, 2017: Cancer
https://www.readbyqxmd.com/read/28199044/prognostic-markers-in-metastatic-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#15
Nir Hirshoren, Julia Danne, Benjamin John Dixon, Matthew Magarey, Stephen Kleid, Angela Webb, Albert Tiong, June Corry, David Gyorki
BACKGROUND: The minority of head and neck cutaneous squamous cell carcinomas (SCC) metastasize to regional lymph nodes. The purpose of this study was to describe the clinical outcomes and prognostic factors for patients with node-positive head and neck cutaneous SCC who underwent lymphadenectomy. METHODS: We conducted a retrospective single center study using the Kaplan-Meier method for the investigation of the overall survival (OS) and locoregional control rates...
February 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/28196217/pathologic-outcomes-of-laparoscopic-vs-open-mesorectal-excision-for-rectal-cancer-a-systematic-review-and-meta-analysis
#16
Aleix Martínez-Pérez, Maria Clotilde Carra, Francesco Brunetti, Nicola de'Angelis
Importance: Rectal resection with mesorectal excision is the mainstay treatment for rectal cancer. Objective: To review and analyze the evidence concerning the pathologic outcomes of laparoscopic (LRR) vs open (ORR) rectal resection for rectal cancer. Data Sources: The Cochrane Central Register of Controlled Trials, MEDLINE (through PubMed), EMBASE, Scopus databases, and clinicaltrials.gov were searched for randomized clinical trials (RCTs) comparing LRR vs ORR...
February 8, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28196023/the-more-the-better-lower-rate-of-stage-migration-and-better-survival-in-patients-with-retrieval-of-20-or-more-regional-lymph-nodes-in-pancreatic-cancer-a-population-based-propensity-score-matched-and-trend-seer-analysis
#17
Rene Warschkow, Bernhard Widmann, Ulrich Beutner, Lukas Marti, Thomas Steffen, Marc Schiesser, Bruno M Schmied
OBJECTIVE: The aim of this study was to assess the influence of regional lymph node (RLN) retrieval on stage migration and survival in pancreatic cancer. METHODS: A total of 7,685 stage I and II pancreatic cancer patients were identified in the Surveillance, Epidemiology, and End Results database in 2004-2011. The impact of RLN was assessed using Cox regression, propensity score methods, and joinpoint regression. RESULTS: In 3,079 patients, 1 to 10 RLNs were retrieved; in 2,799 patients, 11 to 19 RLNs, and in 1,807 patients, 20+ RLNs...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28195303/staging-of-pancreatic-cancer-based-on-the-number-of-positive-lymph-nodes
#18
I Tarantino, R Warschkow, T Hackert, B M Schmied, M W Büchler, O Strobel, A Ulrich
BACKGROUND: The International Study Group on Pancreatic Surgery has stated that at least 12 lymph nodes should be evaluated for staging of pancreatic cancer. The aim of this population-based study was to evaluate whether the number of positive lymph nodes refines staging. METHODS: Patients who underwent pancreatectomy for stage I-II pancreatic cancer between 2004 and 2012 were identified from the Surveillance, Epidemiology, and End Results database. The predictive value of the number of positive lymph nodes for survival was assessed by generalized receiver operating characteristic (ROC) curve analysis and propensity score-adjusted Cox regression analysis...
February 14, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28192599/impact-of-an-alternative-chromosome-17-probe-and-the-2013-american-society-of-clinical-oncology-and-college-of-american-pathologists-guidelines-on-fluorescence-in-situ-hybridization-for-the-determination-of-her2-gene-amplification-in-breast-cancer
#19
Alana R Donaldson, Shashirekha Shetty, Zhen Wang, Christine L Rivera, Bryce P Portier, G Thomas Budd, Erinn Downs-Kelly, Christopher P Lanigan, Benjamin C Calhoun
BACKGROUND: The dual-probe fluorescence in situ hybridization (FISH) assay for human epidermal growth factor receptor 2 (HER2) gene amplification in breast cancer provides an HER2:CEP17 (centromere enumeration probe for chromosome 17) ratio. Copy number alteration (CNA) in CEP17 may skew this ratio. The authors analyzed the impact of the 2013 American Society of Oncology/College of American Pathologists (ASCO/CAP) guidelines and an alternative chromosome 17 probe on HER2 status in tumor specimens with CEP17 CNA...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28192244/prognostic-and-clinical-significance-of-claudin-1-in-colorectal-cancer-a-systemic-review-and-meta-analysis
#20
REVIEW
Lu Jiang, Long Yang, He Huang, Bai-Ying Liu, Guo Zu
BACKGROUND: The current reports on the association of claudin-1 expression with colorectal cancer (CRC) result were controversial. Thus, we conducted a meta-analysis to assess the correlation between claudin-1 expression and the clinical parameters and assess the prognostic value of claudin-1 in CRC. METHODS: Systematic searches on PubMed, Embase, Elsevier, CNKI (China National Knowledge Infrastructure), Wanfang data and Cochrane Library prior to August 2016 were performed...
February 10, 2017: International Journal of Surgery
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