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https://www.readbyqxmd.com/read/29330769/comorbid-insomnia-and-sleep-apnea-in-veterans-with-post-traumatic-stress-disorder
#1
Ali A El-Solh, David Adamo, Thomas Kufel
PURPOSE: The purpose of this study was to determine the impact of insomnia in Veterans with post-traumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) on health-related outcomes before and after 12 weeks of continuous positive airway pressure (CPAP) treatment. METHODS: We conducted a prospective cohort study of Veterans with PTSD and documented apnea hypopnea index (AHI) ≥ 5 with and without clinically significant insomnia as determined by the Insomnia Severity Index (ISI)...
January 10, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29330768/comorbid-insomnia-symptoms-predict-lower-6-month-adherence-to-cpap-in-us-veterans-with-obstructive-sleep-apnea
#2
Douglas M Wallace, A M Sawyer, S Shafazand
PURPOSE: There is limited information on the association between pre-treatment insomnia symptoms and dysfunctional sleep beliefs with continuous positive airway pressure (CPAP) adherence in veterans with obstructive sleep apnea (OSA). Our aims were to describe demographic and sleep characteristics of veterans with and without comorbid insomnia and determine whether pre-treatment insomnia symptoms and dysfunctional sleep beliefs predict CPAP use after 6 months of therapy. METHODS: Hispanic veterans attending the Miami VA sleep clinic were recruited and completed the insomnia severity index, the dysfunctional sleep belief and attitude scale (DBAS), and other questionnaires...
January 4, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29329819/the-effect-of-continuous-positive-airway-pressure-on-spectral-encephalogram-characteristics-in-stroke-patients-with-obstructive-sleep-apnea
#3
Hisham Alshaer, Aditya Pandya, Igor Zivanovic, Carolina Gonzaga Carvalho, Clodagh Ryan
OBJECTIVES: To evaluate if treatment with continuous positive airway pressure (CPAP) compared to usual care in stroke patients with obstructive sleep apnea (OSA) over one month reduces delta and alpha oscillations on quantitative electroencephalography (EEG) in association with improvements in cognitive or functional outcomes. METHODS: Spectral EEG analysis was performed in patients with subacute stroke and OSA randomized to usual care or CPAP treatment from a previous study...
January 9, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29327118/effect-of-cpap-therapy-on-liver-disease-in-patients-with-osa-a-review
#4
REVIEW
Xin Liu, Yuyang Miao, Fan Wu, Tingting Du, Qiang Zhang
Obstructive sleep apnea (OSA) may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD).The effect of continuous positive airway pressure (CPAP) treatment, the first-line therapy for OSA, on liver disease in OSA patients is still debated. We provide this review of previous studies to summarize the effects of CPAP treatment on liver disease in OSA patients in aspects of liver function, liver steatosis, fibrosis, and incidence of liver disease. CPAP treatment may be beneficial to liver disease in subjects with OSA independent of metabolic risk factors, but a sufficiently long therapeutic duration (perhaps greater than 3 months) may be needed to achieve these positive effects...
January 11, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29326331/predicting-response-to-oxygen-therapy-in-obstructive-sleep-apnoea-patients-using-a-10-minute-daytime-test
#5
David Wang, Keith K Wong, Luke Rowsell, Garrick W Don, Brendon J Yee, Ronald R Grunstein
There is no satisfactory treatment for obstructive sleep apnoea (OSA). Supplemental low-flow oxygen therapy (LFO2) has been shown to reduce hypoxaemia and is well tolerated by patients with OSA. However, oxygen therapy may be beneficial only to certain subsets of patients with OSA. In this study, we evaluated a 10-min awake ventilatory chemoreflex test in predicting individual OSA response to 2 months of LFO2 therapy.At baseline, patients with OSA underwent ventilatory chemoreflex testing in the afternoon, prior to the overnight polysomnography...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29318567/phenotyping-the-pathophysiology-of-obstructive-sleep-apnea-using-polygraphy-polysomnography-a-review-of-the-literature
#6
REVIEW
Marcello Bosi, Andrea De Vito, Bhik Kotecha, Luca Viglietta, Alberto Braghiroli, Joerg Steier, Martino Pengo, Giovanni Sorrenti, Riccardo Gobbi, Claudio Vicini, Venerino Poletti
Continuous positive airway pressure (CPAP) is the first-line treatment for the majority of patients affected by obstructive sleep apnea syndrome (OSA). However, long-term compliance with CPAP therapy may result limited and alternatives to CPAP therapy are required to address the increasing need to provide tailored therapeutic options. Understanding the pathophysiological traits (PTs) of OSA patients [upper airway (UA) anatomical collapsibility, loop gain (LG), arousal threshold (AT), and UA gain (UAG)] lies at the heart of the customized OSA treatment...
January 9, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29318566/diagnostic-accuracy-of-level-iv-portable-sleep-monitors-versus-polysomnography-for-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#7
REVIEW
Lusine Abrahamyan, Yeva Sahakyan, Suzanne Chung, Petros Pechlivanoglou, Joanna Bielecki, Steven M Carcone, Valeria E Rac, Michael Fitzpatrick, Murray Krahn
PURPOSE: Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. In-laboratory, overnight type I polysomnography (PSG) is the current "gold standard" for diagnosing OSA. Home sleep apnea testing (HSAT) using portable monitors (PMs) is an alternative testing method offering better comfort and lower costs. We aimed to systematically review the evidence on diagnostic ability of type IV PMs compared to PSG in diagnosing OSA. METHODS: Participants: patients ≥16 years old with symptoms suggestive of OSA;intervention: type IV PMs (devices with < 2 respiratory channels); comparator: in-laboratory PSG; outcomes: diagnostic accuracy measures;studies: cross-sectional, prospective observational/experimental/quasi-experimental studies; information sources: MEDLINE and Cochrane Library from January 1, 2010 to May 10, 2016...
January 9, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29317418/home-polygraphic-recording-with-telemedicine-monitoring-for-diagnosis-and-treatment-of-sleep-apnoea-in-stroke-hopes-study-study-protocol-for-a-single-blind-randomised-controlled-trial
#8
Stefan Thomas Kotzian, Angela Schwarzinger, Sandra Haider, Bernd Saletu, Josef Spatt, Michael Timothy Saletu
INTRODUCTION: Meta-analyses report that more than 50% of patients who had a stroke suffer from moderate to severe sleep apnoea (SA), with adherence rates to positive airway pressure (PAP) therapy of only 30%. The primary objective of this study is to determine whether PAP adherence in patients who had a stroke with obstructive sleep apnoea (OSA) can be improved by a PAP training strategy during inhospital rehabilitation combined with a telemedicine monitoring system after discharge. Further objectives are (1) to compare the validity of a non-attended level-III polygraphy with that of a level-II polysomnography (PSG) in the diagnosis of SA, (2) to compare the validity of an apnoea-hypopnoea index (AHI) yielded by the PAP device with that obtained during PSG, (3) to determine changes in nocturnal systolic blood pressure (BP) due to PAP therapy with the pulse transit time (PTT) method and (4) to assess the impact of telemonitored PAP therapy on neurorehabilitation outcome parameters...
January 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29317326/study-of-the-upper-airway-of-obstructive-sleep-apnea-patient-using-fluid-structure-interaction
#9
Yang Liu, Jennifer Mitchell, Yitung Chen, Woosoon Yim, Wenxiao Chu, Robert C Wang
Up to 14% of the U.S. population is estimated to have obstructive sleep apnea (OSA), while the outcomes of the treatments have variable results. In the current study, a three-dimensional fluid-structure interaction modeling was applied to simulate the upper airway to identify the precise location, severity, and characteristic of airway collapse. This was accomplished using Simpleware® and ANSYS® software applied to a 3-D rendering of the airway in a real patient with severe OSA. During this simulation, areas which are prone to collapse and precipitate apneic episodes were identified at the tip of the soft palate and the base of the tongue, with intrathoracic pressure as low as -1370 Pa...
January 6, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29302924/serum-romo1-is-significantly-associated-with-disease-severity-in-patients-with-obstructive-sleep-apnea-syndrome
#10
Liang Ye, Yingying Qian, Qian Li, Surong Fang, Zhenhua Yang, Yan Tan, Wei Gu
PURPOSE: We aim to evaluate reactive oxygen species modulator 1 (Romo1) levels in obstructive sleep apnea syndrome (OSAS) and analyze its possible relationships to OSAS severity, reactive oxygen species (ROS), and C-reactive protein (CRP). Additionally, we also investigated the effects of nasal continuous positive airway pressure (nCPAP) on serum Romo1. METHODS: One hundred and five patients diagnosed with OSAS were classified into the OSAS group, and 41 subjects without OSAS were recruited for the control group...
January 4, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29301611/validation-of-the-danish-stop-bang-obstructive-sleep-apnoea-questionnaire-in-a-public-sleep-clinic
#11
Asbjørn Kørvel-Hanquist, Ida Gillberg Andersen, Sophie Elisabeth Krogh Lauritzen, Susanne Dahlgaard, Janko Moritz


INTRODUCTION: Obstructive sleep apnoea is common; a prevalence of 1-5% was previously reported. However, only few cases are diagnosed and receive treatment. The aim of this study was to validate the Danish translated version of the STOP-Bang screening tool for obstructive sleep apnoea (OSA) in a public sleep clinic. 
 METHODS: A study population of 208 patients who were referred to a public sleep clinic on suspicion of OSA were assessed with the STOP-Bang questionnaire and at-home cardiorespiratory monitoring in order to assess the quality of the questionnaire as an OSA screening tool...
January 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29301595/secreted-frizzled-related-protein-5-sfrp5-in-patients-with-obstructive-sleep-apnea
#12
Dong-Mei Zhang, Rong Huang, Yi Xiao, Feng-Ying Gong, Xu Zhong, Jin-Mei Luo
Objective Obstructive sleep apnea (OSA) is closely related to obesity, insulin resistance and inflammation. Secreted frizzled-related protein 5 (SFRP5) is a recently discovered adipokine. It is involved in insulin resistance and inflammation in obesity. This study aimed at evaluating the association between SFRP5 and sleeping characteristics as well as biochemical parameters of OSA patients. Methods This was a prospective case control study. Nondiabetic OSA patients and controls were consecutively recruited and divided into three groups: OSA group, apnea-hypopnea Index (AHI)≥5/h; healthy controls with normal body mass index (BMI); obese controls without OSA, and BMI > 24...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29301021/changing-faces-of-osa-treatment-effects-by-cluster-designation-in-the-icelandic-sleep-apnea-cohort
#13
Grace W Pien, Lichuan Ye, Brendan T Keenan, Greg Maislin, Erla Björnsdóttir, Erna Sif Arnardottir, Bryndis Benediktsdottir, Thorarinn Gislason, Allan I Pack
Study Objectives: Distinct clinical phenotypes of obstructive sleep apnea (OSA) have been identified: Disturbed Sleep, Minimally Symptomatic, and Sleepy. Determining whether these phenotypes respond differently to standard treatment helps create a foundation for personalized therapies. We compared responses to positive airway pressure (PAP) therapy in these clinical OSA phenotypes. Methods: The study sample included 706 patients from the Icelandic Sleep Apnea Cohort with moderate-to-severe OSA who were prescribed PAP...
January 2, 2018: Sleep
https://www.readbyqxmd.com/read/29298664/the-prevention-of-delirium-in-elderly-with-obstructive-sleep-apnea-podesa-study-protocol-for-a-multi-centre-prospective-randomized-controlled-trial
#14
Jean Wong, David Lam, Stephen Choi, Mandeep Singh, Naveed Siddiqui, Sanjeev Sockalingam, Frances Chung
BACKGROUND: Delirium is a common problem that occurs in 5-50% of elderly individuals following surgery. Patients who develop delirium after surgery are at increased risk for serious complications. Recent studies suggest that patients with obstructive sleep apnea (OSA), a sleep disorder characterized by repeated episodes of complete or partial blockage of the upper airway - are at greater risk to develop delirium. OSA is more common in elderly individuals but is often undiagnosed. Identification and treatment of unrecognized OSA may reduce the incidence of postoperative delirium...
January 3, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29298526/comparison-of-radiofrequency-and-transoral-robotic-surgery-in-obstructive-sleep-apnea-syndrome-treatment
#15
Engin Aynacı, Murat Karaman, Burak Kerşin, Mahmut Ozan Fındık
INTRODUCTION: Radiofrequency tissue ablation (RFTA) and transoral robotic surgery (TORS) are the methods used in OSAS surgery. We also aimed to compare the advantages and disadvantages of RF and TORS as treatment methods applied in OSAS patients in terms of many parameters, especially apnea hypopnea index (AHI). MATERIALS AND METHODS: Patients were classified by performing a detailed examination and evaluation before surgery. 20 patients treated with anterior palatoplasty and uvulectomy -/+ tonsillectomy + RFTA (17 males, 3 females) and 20 patients treated with anterior palatoplasty and uvulectomy -/+  tonsillectomy + TORS (16 males, 4 females) were included in the study...
January 3, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29298404/predictors-of-obstructive-sleep-apnea-in-consecutive-patients-with-metabolic-syndrome
#16
Rodrigo P Pedrosa, Cristiane Maki-Nunes, Thiago Midlej-Brito, Heno F Lopes, Lunara S Freitas, Ivani C Trombetta, Edgar Toschi-Dias, Maria Janieire N N Alves, Raffael F Fraga, Maria U Rondon, Carlos E Negrão, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Luciano F Drager
BACKGROUND: Recent evidence suggests that obstructive sleep apnea (OSA) is common in patients with metabolic syndrome (MetS) and may contribute to metabolic deregulation, inflammation, and atherosclerosis in these patients. In clinical practice, however, OSA is frequently underdiagnosed. We sought to investigate the clinical predictors of OSA in patients with MetS. METHODS: We studied consecutive patients newly diagnosed with MetS (Adult Treatment Panel-III). All participants underwent clinical evaluation, standard polysomnography, and laboratory measurements...
January 3, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29296051/effects-of-continuous-positive-airway-pressure-on-anxiety-depression-and-major-cardiac-and-cerebro-vascular-events-in-obstructive-sleep-apnea-patients-with-and-without-coronary-artery-disease
#17
Ming-Chung Lee, Yu-Chih Shen, Ji-Hung Wang, Yu-Ying Li, Tzu-Hsien Li, En-Ting Chang, Hsiu-Mei Wang
Objective: Obstructive sleep apnea (OSA) is associated with bad cardiovascular outcomes and a high prevalence of anxiety and depression. This study investigated the effects of continuous positive airway pressure (CPAP) on the severity of anxiety and depression in OSA patients with or without coronary artery disease (CAD) and on the rate of cardio- and cerebro-vascular events in those with OSA and CAD. Materials and Methods: This prospective study included patients with moderate-to-severe OSA, with or without a recent diagnosis of CAD; all were started on CPAP therapy...
October 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29289684/upper-airway-areas-volumes-and-linear-measurements-determined-on-computed-tomography-during-different-phases-of-respiration-predict-the-presence-of-severe-obstructive-sleep-apnea
#18
Khaisang Chousangsuntorn, Thongchai Bhongmakapat, Navarat Apirakkittikul, Witaya Sungkarat, Nucharin Supakul, Jiraporn Laothamatas
PURPOSE: The objective of this study was to analyze the potential of using low-dose volumetric computed tomography (CT) during different phases of respiration for identifying patients likely to have severe obstructive sleep apnea (OSA), defined as a respiratory disturbance index (RDI) higher than 30. PATIENTS AND METHODS: A prospective study was undertaken at the Ramathibodi Hospital (Bangkok, Thailand). Patients with diagnosed OSA (N = 82) were recruited and separated into group 1 (RDI, ≤30; n = 36) and group 2 (RDI, >30; n = 46)...
December 9, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29288649/posterior-airway-changes-following-orthognathic-surgery-in-obstructive-sleep-apnea
#19
REVIEW
Sophia Gottsauner-Wolf, Johannes Laimer, Emanuel Bruckmoser
PURPOSE: The purpose of this systematic review was to describe and compare the different approaches of radiologic posterior airway space (PAS) assessment in obstructive sleep apnea (OSA) and analyze the correlations of PAS changes with polysomnographically evaluated parameters after orthognathic surgery. MATERIALS AND METHODS: For this systematic review, a PubMed query was designed to search for original studies radiographically evaluating the PAS in patients before and after orthognathic surgery for treatment of their OSA...
December 6, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29288566/double-suspension-sutures-a-simple-surgical-technique-for-selected-cases-of-obstructive-sleep-apnea-our-experience-with-twenty-two-patients
#20
Sherif M Askar, Mohammad W El-Anwar
This work aimed at presenting a simple modification of expansion pharyngoplasty using bilateral double palatal suspension sutures for the treatment of selected cases of snoring and OSA. Between Marsh 2013 and August 2017, twenty- two patients underwent the double suspension sutures technique as a treatment for retropalatal collapse of obstructive sleep apnea. Postoperatively, the mean AHI and the mean lowest oxygen saturation level showed highly significant improvement. Both the retropalatal and interpillar distances were increased significantly...
December 30, 2017: Clinical Otolaryngology
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