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JOURNAL ARTICLE
Thomas Ferenc, Jelena Svetec Dvorski, Andro Matković, Maja Mijić, Eva Lovrić, Vinko Vidjak
Pseudokidney sign (PKS) is a characteristic sonographic finding of an abnormal mass with a reniform appearance, and a hyperechoic central region surrounded by a hypoechoic area. It has been seldom documented in gastric cancer. A 75-year-old male patient presented with a palpable abdominal resistance in the left upper abdominal quadrant and ultrasound evaluation revealed a well-vascularized mass presenting with PKS. Regional lymphadenopathy was also found, and the working diagnosis of gastric cancer was established...
April 25, 2024: Diagnostics
#2
JOURNAL ARTICLE
Clara Long, Abdulrahman Al-Abdulmalek, Jonathan Lai, David G Haegert, Stephane Isnard, Denis Cournoyer, Jean-Pierre Routy
BACKGROUND: Autoimmune diseases are not contraindications for immune checkpoint inhibitors (ICI) therapy in patients with cancer. However, immune-related adverse events (irAEs) are frequently observed in patients receiving ICIs including dermatitis, thyroiditis, colitis, and pneumonitis. Thrombocytopenic purpura, aplasia, and haemophagocytic lymphohistiocytosis (HLH) are rarely observed during ICIs. CASE DESCRIPTION: We report the case of a male patient with pre-existing untreated HLA B27 and ankylosing spondylitis with gastric cancer and liver metastases...
2024: European Journal of Case Reports in Internal Medicine
#3
JOURNAL ARTICLE
Wenjing Jia, Fuyan Li, Yi Cui, Yong Wang, Zhengjun Dai, Qingqing Yan, Xinhui Liu, Yuting Li, Huan Chang, Qingshi Zeng
RATIONALE AND OBJECTIVES: To develop and validate a deep learning radiomics (DLR) model based on contrast-enhanced computed tomography (CT) to identify the primary source of liver metastases. MATERIALS AND METHODS: In total, 657 liver metastatic lesions, including breast cancer (BC), lung cancer (LC), colorectal cancer (CRC), gastric cancer (GC), and pancreatic cancer (PC), from 428 patients were collected at three clinical centers from January 2018 to October 2023 series...
May 2, 2024: Academic Radiology
#4
JOURNAL ARTICLE
Kaori Katsumata, Yosuke Morimoto, Junya Aoyama, Toru Yamada, Yusuke Katsuki, Ryo Nishiyama, Tomohisa Egawa
BACKGROUND: Nivolumab combination chemotherapy has recently emerged as a potential first-line treatment for patients with unresectable or metastatic gastric cancer (GC). Further research has indicated that R0 resection by conversion surgery could be an effective treatment strategy to improve overall survival. However, there have been limited reports on the successful application of conversion surgery following combination chemotherapy achieving pathological complete response (pCR) in cases of advanced gastric remnant cancer with liver metastasis...
May 1, 2024: Surgical Case Reports
#5
Laura Lorenzon, Andrea Campisi, Alessandra Di Paolo, Felice Giuliante, Fiamma Buttitta, Domenico D'Ugo
BACKGROUND: Globally, gastric cancer holds the fifth position in terms of prevalence among malignant tumors and is the fourth leading cause of cancer-related mortality. Particular attention should be paid to cardia adenocarcinoma (CA) due to its increasing incidence and poor prognosis. Diagnosis of CA frequently occurs in advanced stages because of its late symptoms. In such cases, neoadjuvant chemotherapy is the primary treatment option. The response to chemotherapy depends on multiple variables including the tumor's molecular profile, the patient's performance status, and the feasibility of using targeted therapy...
2024: Frontiers in Surgery
#6
JOURNAL ARTICLE
Pegah Sahafi, Kamran Aryana, Soroush Zarehparvar Moghadam, Kayvan Sadri, Emran Askari
In a recent 99mTc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO4- in the injected vial. The scans were repeated after confirming acceptable radiopharmaceutical purity of 97% (normal range, 95%-100%). Interestingly, 1 patient had liver metastases at presentation, which remained non-PSMA-avid after repeating the scan...
April 30, 2024: Clinical Nuclear Medicine
#7
JOURNAL ARTICLE
Bin Wang, Xinming Zhao, Yunuan Liu, Zhaoqi Zhang, Xiaoshan Chen, Fenglian Jing, Xiaolin Chen, Yu Hua, Jianqiang Zhao
OBJECTIVE: The objective of this study is to evaluate the effectiveness of 68Ga-FAPI-04 PET/computed tomography (CT) for the diagnosis of primary and metastatic gastric cancer and colorectal cancer lesions as compared with 18F-FDG PET/CT. MATERIALS AND METHODS: Fifty-nine patients who underwent both 18F-FDG and 68Ga-FAPI-04 for initial staging or restaging were enrolled. Histopathological findings and clinical imaging follow-up were used as the reference standard...
April 29, 2024: Nuclear Medicine Communications
#8
Fumiyoshi Ikejiri, Kanako Yokomizo, Kenji Tamura
Gastric cancer (GC) is a globally prevalent and deadly malignancy often diagnosed at advanced stages, which can be accompanied by liver metastases. Conventional chemotherapy is contraindicated in patients with severe liver failure because several chemotherapeutic agents are metabolized by the liver. The present study reports on the successful use of nivolumab in a patient with advanced GC and severe liver failure owing to multiple liver metastases. A 57-year-old man was admitted to Shimane Prefectural Central Hospital (Izumo, Japan) with a 2-week history of appetite loss and jaundice...
June 2024: Oncology Letters
#9
JOURNAL ARTICLE
Ayaka Nomura, Yusuke Akamaru, Kentaro Nishida, Soichiro Mori, Akinobu Yasuyama, Masatoshi Nomura, Yukihiro Yoshikawa, Koki Tamai, Daisuke Takiuchi, Takuya Hamakawa, Mitsuyoshi Tei, Masanori Tsujie
A 77-year-old man presented to our hospital with a chief complaint of stomachache. He received a diagnosis of unresectable advanced gastric cancer classified as cT3, N+, M1(LYM, HEP, OSS), Stage ⅣB. He underwent first-line chemotherapy with SOX, second-line treatment with PTX plus Ram, and third-line treatment with nivolumab. The primary tumor showed a reduction in size, and liver and lymph node metastases were not detectable. However, after 5 years of chemotherapy, a re- enlargement was observed in the primary gastric lesion without progression of liver and lymph node metastases...
April 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#10
JOURNAL ARTICLE
Tetsushi Nakagawa, Yuji Yamamoto, Senichiro Yanagawa, Shohei Shiozaki, Yuuki Kaneko, Atsuhiro Watanabe, Mai Nishina, Daisuke Takei, Yusuke Sumi, Minoru Yamaki, Manabu Kurayoshi, Junji Hashizume, Akihiko Oshita, Masahiro Nakahara, Toshio Noriyuki
A 67-year-old man visited our hospital for epigastric pain. Esophagogastroduodenoscopy(EGD)revealed type 2 gastric cancer from the cardia to the gastric angle, and histopathological examination revealed papillary adenocarcinoma(pap), HER2-positive. Contrast-enhanced CT showed wall thickening mainly in the posterior wall of the gastric body, enlarged lymph nodes that were lumped together with the main lesion, and 8 low-absorption areas with ring shaped contrast effects in both lobes of the liver. The patient was diagnosed as gastric cancer cT4aN(+)M1[HEP], clinical Stage ⅣB...
April 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#11
JOURNAL ARTICLE
Paolo Morgagni, Maria Bencivenga, Fatima Carneiro, Stefano Cascinu, Sarah Derks, Maria Di Bartolomeo, Claire Donohoe, Clarisse Eveno, Suzanne Gisbertz, Peter Grimminger, Ines Gockel, Heike Grabsh, Paulo Kassab, Rupert Langer, Sara Lonardi, Marco Maltoni, Sheraz Markar, Markus Moehler, Daniele Marrelli, Maria Antonietta Mazzei, Davide Melisi, Carlo Milandri, Paul Stefan Moenig, Bianca Mostert, Gianni Mura, Wojciech Polkowski, John Reynolds, Luca Saragoni, Mark I Van Berge Henegouwen, Richard Van Hillegersberg, Michael Vieth, Giuseppe Verlato, Lorena Torroni, Bas Wijnhoven, Guido Alberto Massimo Tiberio, Han-Kwang Yang, Franco Roviello, Giovanni de Manzoni
BACKGROUND: Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but a general agreement on managing oligometastatic disease has yet to be achieved. An international multi-disciplinary workshop was held in Bertinoro, Italy, in November 2022 to verify whether achieving a consensus on at least some topics was possible...
April 18, 2024: Gastric Cancer
#12
JOURNAL ARTICLE
Yingxiang Wu, Yijun Guo, Wen Luo
BACKGROUND: Gastric cancer (GC), considered the fifth most prevalent malignancy, is the fourth leading cause of cancer death worldwide. This cancer is heterogeneous and invasive and often metastasizes to the liver. The survival of patients with GC, especially cancer-specific survival (CSS), is a matter of concern to their families and medical workers in clinical practice. However, efficient tools for early risk prediction are lacking. Thus, this study aimed to develop a nomogram for forecasting the overall survival (OS) and CSS of patients with GC with liver metastasis (GCLM) based on the Surveillance, Epidemiology, and End Results (SEER) database...
March 18, 2024: Journal of Gastrointestinal Surgery
#13
JOURNAL ARTICLE
Jun Yeb Nam, Jung Wook Lee, Jae Hyun Kim, Minjung Jung, Moo In Park, Won Moon, Sung Eun Kim, Kyoungwon Jung, Seun Ja Park
RATIONALE: Colorectal cancer is the third most common cancer diagnosed worldwide. At the time of diagnosis of colorectal cancer, one of the most common metastatic sites is liver. Gastric metastasis from colorectal origin is rare. Moreover, a direct invasion of the stomach, by hepatic metastasis from colorectal cancer, is particularly uncommon. PATIENT CONCERNS: A 56-year-old male patient with hematochezia was referred to our hospital. DIAGNOSIS: The patient was diagnosed with unresectable colorectal cancer because of the presence of >10 metastases involving both lobes of the liver...
April 12, 2024: Medicine (Baltimore)
#14
JOURNAL ARTICLE
Hong Zhang, Xia Cheng, Wenqin Guo, Cheng Zheng, Yue Zhang, Xiaoying Jing, Hui Qiao
BACKGROUND: Whether young patients with metastatic gastric cancer (GC) had distinct metastasis patterns and survival outcomes from older patients remains controversial. The aim of the present study was to explore the metastasis patterns and prognostic factors in young patients and evaluate the survival outcome in comparison to their older counterparts. MATERIALS AND METHODS: We identified patients with metastatic GC in the surveillance, epidemiology, and end results (SEER) database from 2010 to 2015...
2024: PloS One
#15
JOURNAL ARTICLE
Naoe Yanagisawa, Naohiko Koide, Harunari Fukai, Yoshinori Koyama, Yuu Ogihara, Maki Ohya
BACKGROUND: The serum level of Krebs von den Lungen-6 (sKL-6) is a biomarker of interstitial pneumonia and has been reported to be elevated in patients with cancers. However, there have been few cases of gastric cancer (GC) with elevated sKL-6 that were treated by chemotherapy. We herein report two cases of GC with elevated sKL-6 that were treated with oxaliplatin plus S-1 (SOX) chemotherapy and discussed the resulting changes in sKL-6. CASE PRESENTATION: The first patient was a 79-year-old woman complaining of loss of appetite...
April 9, 2024: Surgical Case Reports
#16
JOURNAL ARTICLE
Kai Liu, Chun-Xiao Wu, Hui Liang, Tao Wang, Ji-Yuan Zhang, Xiao-Tao Wang
BACKGROUND: Gastric cancer (GC) is the fifth most common type of cancer and has the fourth highest death rate among all cancers. There is a lack of studies examining the impact of liver metastases on the effectiveness of immunotherapy in individuals diagnosed with GC. AIM: To investigate the influence of liver metastases on the effectiveness and safety of immunotherapy in patients with advanced GC. METHODS: This retrospective investigation collected clinical data of patients with advanced stomach cancer who had immunotherapy at our hospital from February 2021 to January 2023...
March 27, 2024: World Journal of Gastrointestinal Surgery
#17
JOURNAL ARTICLE
Naohiko Nakamura, Shinichi Kinami, Daisuke Kaida, Yasuto Tomita, Takashi Miyata, Tomoharu Miyashita, Hideto Fujita, Nobuhiko Ueda, Hiroyuki Takamura
INTRODUCTION: This study aimed to evaluate the prognostic factors in T4b gastric cancer (GC) in order to improve future therapeutic strategies. METHODS: We retrospectively analyzed the medical records of 43 patients with advanced GC who underwent surgery and were surgically or pathologically diagnosed with T4b GC. The overall survival (OS) rate of patients with T4b GC was analyzed, and univariate and multivariate analyses were performed to identify clinicopathological factors that were independently associated with OS...
January 1, 2024: Journal of Cancer Research and Therapeutics
#18
JOURNAL ARTICLE
L Li, Y H Gao, L Zang, K Xue, B Ke, L Shang, Z Q Tang, J Yu, Y R Liang, Z R He, H L Zheng, H Huang, J P Xiong, Z Y He, J Y Li, T T Lu, Q Y Song, S H Liu, Y W Chen, Y Tang, H Liang, Z Qiao, L Chen
Objective: To examine the impact of varied surgical treatment strategies on the prognosis of patients with initial resectable gastric cancer liver metastases (IR-GCLM). Methods: This is a retrospective cohort study. Employing a retrospective cohort design, the study selected clinicopathological data from the national multi-center retrospective cohort study database, focusing on 282 patients with IR-GCLM who underwent surgical intervention between January 2010 and December 2019. There were 231 males and 51 males, aging ( M (IQR)) 61 (14) years (range: 27 to 80 years)...
March 27, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
#19
JOURNAL ARTICLE
Y H Gao, L Li, L Chen
In recent years, advances in surgical techniques and evolving concepts have significantly improved treatment strategies and prognosis for patients with gastric cancer liver metastases. In particular, patients diagnosed with initially resectable gastric cancer liver metastases shows marked improvement in survival. Despite variations in the definition of initially resectable gastric cancer liver metastases among different consensus and guidelines, surgical resection and hepatic physiotherapy are increasingly crucial components of comprehensive treatment...
March 27, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
#20
JOURNAL ARTICLE
Natsumi Suzuki, Anna Matsuoka, Masao Horiuchi, Akinori Sasaki, Yasuaki Motomura
Immune checkpoint inhibitors have been approved for treating various cancer types. However, several studies reported rapid tumor progression, a condition known as hyperprogressive disease, after treatment with immune checkpoint inhibitors. We present the case of a 73-year-old man diagnosed with recurrent gastric cancer with liver and lymph node metastases detected in the presence of obstructive jaundice. Concomitant administration of nivolumab with cytotoxic chemotherapy as first-line chemotherapy effectively controlled the tumor...
April 2024: International cancer conference journal
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