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JOURNAL ARTICLE
Chintan V Dave, Yongmei Li, Michael A Steinman, Sei J Lee, Xiaojuan Liu, Bocheng Jing, Laura A Graham, Zachary A Marcum, Kathy Z Fung, Michelle C Odden
IMPORTANCE: Limited evidence exists on the association between initiation of antihypertensive medication and risk of fractures in older long-term nursing home residents. OBJECTIVE: To assess the association between antihypertensive medication initiation and risk of fracture. DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective cohort study using target trial emulation for data derived from 29 648 older long-term care nursing home residents in the Veterans Health Administration (VA) from January 1, 2006, to October 31, 2019...
April 22, 2024: JAMA Internal Medicine
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JOURNAL ARTICLE
Silvia Manea, Marco Pinato, Laura Salmaso, Silvia Vittorii, Michela Biasio, Matteo Rigoni, Vinicio Manfrin, Elisabetta Bertocco, Mirko Zanatta, Mario Saia
BACKGROUND: During COVID-19 pandemic, health professionals have been working in an extreme uncertainty context. Affected patients needed to be cared at home as long as possible to avoid virus spreading and hospital resources saturation. The Veneto Regional Administration (North-east of Italy) released Regional guidelines about it. The Western Healthcare District of the Local Health Authority of the city of Vicenza (180,000 inhabitants) implemented a healthcare pathway following them. Aim of the study is to describe the results and outcomes of such implementation...
April 12, 2024: Annali di Igiene: Medicina Preventiva e di Comunità
#3
REVIEW
Jyotirmayee Lenka, Raymond Foley, Mark Metersky, Adrian Salmon
INTRODUCTION: Obstructive sleep apnea (OSA) is a widely prevalent condition with consequent multiple organ systems complications. There is consensus that OSA is associated with negative effects on pulmonary hemodynamics but whether it contributes to development of clinical pulmonary hypertension (PH) is unclear. AREAS COVERED: In this review we 1) highlight previous studies looking into the possible bidirectional association of OSA and PH, focusing on those that explore clinical prognostic implications, 2) explore potential pathophysiology, 3) discuss the new metrics in OSA, 4) describe endo-phenotyping of OSA, 5) recommend possible risk assessment and screening pathways...
April 22, 2024: Expert Review of Respiratory Medicine
#4
JOURNAL ARTICLE
Saptaswa Dey, Pablo Augusto Vieyra-Garcia, Aaroh Anand Joshi, Slave Trajanoski, Peter Wolf
Cutaneous T-cell lymphomas (CTCL) are a group of lymphoproliferative disorders of skin-homing T cells causing chronic inflammation. These disorders cause impairment of the immune environment, which leads to severe infections and/or sepsis due to dysbiosis. In this study, we elucidated the host-microbial interaction in CTCL that occurs during the phototherapeutic treatment regime and determined whether modulation of the skin microbiota could beneficially affect the course of CTCL. EL4 T-cell lymphoma cells were intradermally grafted on the back of C57BL/6 mice...
2024: Frontiers in Immunology
#5
Joseph Bonanno, Timothy Grannell, Gregory Maves, Joseph D Tobias
In pediatric-aged patients, hyperthyroidism generally results from the autoimmune disorder, Graves' disease (GD). Excessive levels of thyroid hormones (triiodothyronine and thyroxine) result in irritability, emotional lability, nervousness, tremors, palpitations, tachycardia, and arrhythmias. The risk of morbidity and mortality is increased when surgical intervention is required in patients with hyperthyroidism due to the potential for the development of thyroid storm (TS). A 3-year, 1-month-old child with a past medical history of GD presented for total thyroidectomy when pharmacologic control with methimazole was not feasible due to intolerance following development of a serum sickness-like illness...
April 2024: Journal of Medical Cases
#6
JOURNAL ARTICLE
Rajesh P Karyakarte, Rashmita Das, Mansi V Rajmane, Sonali Dudhate, Jeanne Agarasen, Praveena Pillai, Priyanka M Chandankhede, Rutika S Labhshetwar, Yogita Gadiyal, Preeti P Kulkarni, Safanah Nizarudeen, Sushma Yanamandra, Nyabom Taji, Suvarna Joshi, Varsha Potdar
BACKGROUND: In August 2023, the BA.2.86 SARS-CoV-2 variant, with over 30 spike protein mutations, emerged amidst the global dominance of XBB sub-lineages. It evolved into JN.1 by late 2023, spreading across 71 countries. JN.1, distinct for its L455S mutation, significantly dominated global sequences, raising concerns over its transmission and clinical impact. The study investigates JN.1's clinical severity and its effect on hospital admissions in Maharashtra, India. METHODOLOGY: The present study involved 3,150 curated Indian SARS-CoV-2 whole genome sequences with collection dates between 1st August 2023 and 15th January 2024...
March 2024: Curēus
#7
JOURNAL ARTICLE
Franciska Brezan, Maximilian Meyer, Marc Vogel, Jakob Heimer, Luis Falcato, Jonas Montagna, Philip Bruggmann
BACKGROUND AND AIMS: Legal regulations for dispensing in Swiss heroin-assisted treatment were relaxed during the COVID-19 pandemic, allowing prolonged take-home of up to 7 days instead of two to reduce patient contact and the risk of infection. Our study aimed to measure the consequences of this new practice. DESIGN, SETTING AND PARTICIPANTS: This was a retrospective cohort study set in Switzerland's largest outpatient centre for opioid agonist therapy. One hundred and thirty-four (72...
April 21, 2024: Addiction
#8
JOURNAL ARTICLE
Sierra Chichester, Adline Rahmoune, Hassan S Dashti
BACKGROUND: Patients receiving home parenteral nutrition (HPN) are known to experience psychological distress and have profoundly disrupted sleep. The aim of this analysis was to examine the relationship between sleep patterns with depressive symptoms and HPN characteristics. METHODS: The study was a secondary analysis of cross-sectional data examining sleep patterns using subjective and objective measures. Sleep was assessed by surveys and 7-day actigraphy. The Patient Health Questionnaire-8 was used to evaluate depressive symptoms...
April 21, 2024: JPEN. Journal of Parenteral and Enteral Nutrition
#9
RANDOMIZED CONTROLLED TRIAL
David E Teytelbaum, Neil S Kumar, Craig S Dent, Spencer Neaville, Deborah H Warren, Peter Simon, Christopher E Baker
BACKGROUND: Historically, in-person physical therapy serves as a foundational component of nonoperative treatment of adhesive capsulitis (AC). This study compares the effectiveness of an at-home high-intensity stretch (HIS) device to traditional physical therapy (PT) and to PT in combination with the HIS device. We hypothesize that the HIS device will be as effective as PT alone or as combination therapy in the first-line treatment of AC and use of the HIS device will exhibit improvement at higher rate...
April 20, 2024: BMC Musculoskeletal Disorders
#10
JOURNAL ARTICLE
Xiaodan Jiao, Xiaoyang Li, Yan Du, Yiyang Cong, Shuyang Yang, Daiqin Chen, Tao Zhang, Min Feng, Hao Hong
Sonodynamic therapy (SDT) has emerged as a useful approach for tumor treatment. However, its widespread application is impeded by poor pharmacokinetics of existing sonosensitizers. Here we developed a metal-organic nanoplatform, wherein a small-molecule sonosensitizer (hematoporphyrin monomethyl ether, HMME) was ingeniously coordinated with zirconium, resulting in a multifunctional nanosonosensitizer termed Zr-HMME. Through post-synthetic modifications involving PEGylation and tumor-targeting peptide (F3) linkage, a nanoplatform capable of homing on melanoma was produced, which could elicit robust immune responses to suppress tumor lung metastasis in the host organism...
April 18, 2024: Journal of Controlled Release
#11
JOURNAL ARTICLE
Justin Han, Michael Tilkens, Macary Weck Marciniak, Laura A Rhodes
BACKGROUND: The influence of adverse factors on social determinants of health (SDOH) and their impact on patient outcomes is widely recognized. Pharmacists, as accessible healthcare professionals, can play a pivotal role in identifying and addressing SDOH concerns. Health system specialty pharmacies have consistently assisted patients in accessing expensive specialty medications and ensuring adherence to therapy. As such, they are uniquely positioned to address SDOH concerns of patients...
April 18, 2024: Journal of the American Pharmacists Association: JAPhA
#12
JOURNAL ARTICLE
Christopher Bliemel, Robert Birkelbach, Tom Knauf, Bastian Pass, Benjamin Craiovan, Carsten Schoeneberg, Steffen Ruchholtz, Martin Bäumlein
BACKGROUND AND OBJECTIVES: The outcomes of patients with atypical subtrochanteric fractures (ASFs) remain unclear. Data from a large international geriatric trauma registry were analysed to examine the outcome of patients with ASFs compared to patients with typical osteoporotic subtrochanteric fractures (TSFs). MATERIALS AND METHODS: Data from the Registry for Geriatric Trauma of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie [DGU]) (ATR-DGU) were analysed...
April 20, 2024: Archives of Orthopaedic and Trauma Surgery
#13
JOURNAL ARTICLE
Nur Fasihah Mat Nawi, Anna Alicia Simok, Muhammad Hafiz Hanafi, Zul Izhar Mohd Ismail
INTRODUCTION: Stroke has emerged as the leading cause of disability globally. The provision of long-term rehabilitation to stroke survivors poses a health care burden to many countries. Robotic devices have created a major turning point in stroke rehabilitation program. Currently, the anthropometric evidence to support the benefit of robotic rehabilitation (RR) among stroke patients is scarce. Therefore, the aim of this study was to evaluate the impact of RR on the mid-thigh circumferences of the paretic limbs in stroke patients...
April 2024: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
#14
JOURNAL ARTICLE
Anne Kaggiah, Catherine N Maina, John Kinuthia, Douglas Barthold, Brett Hauber, Jacinda Tran, Jane M Simoni, Susan M Graham
BACKGROUND: In 2020, 14% of diagnosed persons living with HIV (PLWH) in Kenya were not taking antiretroviral therapy (ART), and 19% of those on ART had unsuppressed viral loads. Long-acting antiretroviral therapy (LA-ART) may increase viral suppression by promoting ART uptake and adherence. We conducted key informant (KI) interviews with HIV experts in Kenya to identify product and delivery attributes related to the acceptability and feasibility of providing LA-ART to PLWH in Kenya. METHODS: Interviews were conducted via Zoom on potential LA-ART options including intra-muscular (IM) injections, subcutaneous (SC) injections, implants, and LA oral pills...
April 19, 2024: BMC Infectious Diseases
#15
JOURNAL ARTICLE
Jun Liu, Xiaoyu Hu, Guanghao Yu, Qingrong Wang, Liwei Gu, Jianying Shen, Qinghe Zhao, Hao Sun, Shi Wang, Zhongyuan Guo, Yu Zhao, Hai Ma
Alpha-enolase (ENO1), a multifunctional protein with carcinogenic properties, has emerged as a promising cancer biomarker because of its differential expression in cancer and normal cells. On the basis of this characteristic, we designed a cell-targeting peptide that specifically targets ENO1 and connected it with the drug doxorubicin (DOX) by aldehyde-amine condensation. A surface plasmon resonance (SPR) assay showed that the affinity for ENO1 was stronger (KD = 2.5 µM) for the resulting cell-targeting drug, DOX-P, than for DOX...
April 17, 2024: Biochemical Pharmacology
#16
JOURNAL ARTICLE
Rudolph A Rodriguez, Matthew A Sparks, Paul T Conway, Anamika Gavhane, Siddharta Reddy, Linda Awdishu, Sana Waheed, Sandra Davidson, Deborah B Adey, Janice P Lea, John C Lieske, Furman S McDonald
In 1988, the American Board of Internal Medicine (ABIM) defined essential procedural skills in nephrology, and candidates for ABIM certification were required to present evidence of possessing the skills necessary for placement of temporary dialysis vascular access, hemodialysis, peritoneal dialysis, and percutaneous renal biopsy. In 1996, continuous renal replacement therapy was added to the list of nephrology requirements. These procedure requirements have not been modified since 1996 while the practice of nephrology has changed dramatically...
April 17, 2024: American Journal of Kidney Diseases
#17
JOURNAL ARTICLE
Pablo Canales-Herrerias, Mathieu Uzzan, Akihiro Seki, Rafael S Czepielewski, Bram Verstockt, Alexandra E Livanos, Fiona Raso, Alexandra Dunn, Daniel Dai, Andrew Wang, Zainab Al-Taie, Jerome Martin, Thomas Laurent, Huaibin M Ko, Minami Tokuyama, Michael Tankelevich, Hadar Meringer, Francesca Cossarini, Divya Jha, Azra Krek, John D Paulsen, Matthew D Taylor, Mohammad Zuber Nakadar, Joshua Wong, Emma C Erlich, Rachel L Mintz, Emily J Onufer, Beth A Helmink, Keshav Sharma, Adam Rosenstein, Danielle Ganjian, Grace Chung, Travis Dawson, Julius Juarez, Vijay Yajnik, Andrea Cerutti, Jeremiah J Faith, Mayte Suarez-Farinas, Carmen Argmann, Francesca Petralia, Gwendalyn J Randolph, Alexandros D Polydorides, Andrea Reboldi, Jean-Frederic Colombel, Saurabh Mehandru
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7+ ) plasmablasts in circulation of VDZ-treated patients suggested that VDZ targets gut-associated lymphoid tissue (GALT). Anti-α4β7 blockade in wild-type and photoconvertible (KikGR) mice confirmed a loss of GALT size and cellularity because of impaired cellular entry...
April 19, 2024: Science Immunology
#18
JOURNAL ARTICLE
Brittany M St John, Karla K Ausderau
IMPORTANCE: Caregivers are essential partners in caregiver-mediated interventions that build on family routines and practices. Research identifying how participation as an intervention partner influences caregivers' outcomes, including stress and self-efficacy, is scarce. OBJECTIVE: To evaluate caregiver outcomes (stress, self-efficacy, and positive feeding responses and confidence) after participation in the Engaged Eaters Program. DESIGN: Quasi-experimental pretest-posttest design...
May 1, 2024: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
#19
JOURNAL ARTICLE
Sarah E Wallace, Elena V Donoso Brown, Jaime B Lee, Katherine L Janov, Mariana Pachecho Busquets
PURPOSE: The study purpose was to compare the practice patterns captured by self-reported logbook data and those recorded by a computerized home program application. The current study is part of a larger single-case research design study aimed at investigating the effect of logbook use on home program adherence in people with aphasia poststroke. METHOD: Data from six adults with chronic aphasia with interest in improving their reading were used in this secondary analysis...
April 19, 2024: American Journal of Speech-language Pathology
#20
JOURNAL ARTICLE
Hong Xiao, Xiaoxia Li, Simin Liang, Shuguang Yang, Shisong Han, Jinsheng Huang, Xintao Shuai, Jie Ren
Effective antitumor immunotherapy depends on evoking a cascade of cancer-immune cycles with lymph nodes (LNs) as the initial sites for activating antitumor immunity, making drug administration through the lymphatic system highly attractive. Here, we describe a nanomedicine with dual responsiveness to pH and enzyme for a programmed activation of antitumor immune through the lymphatic system. The proposed nanomedicine can release the STING agonist diABZI-C2-NH2 in the LNs' acidic environment to activate dendritic cells (DCs) and T cells...
April 19, 2024: ACS Nano
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