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https://www.readbyqxmd.com/read/29471014/epigenomic-drugs-and-the-germline-collateral-damage-in-the-home-of-heritability
#1
REVIEW
Patrick S Western
The testis and ovary provide specialised environments that nurture germ cells and facilitate their maturation, culminating in the production of mature gametes that can found the following generation. The sperm and egg not only transmit genetic information, but also epigenetic modifications that affect the development and physiology of offspring. Importantly, the epigenetic information contained in mature sperm and oocytes can be influenced by a range of environmental factors, such as diet, chemicals and drugs...
February 19, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29470703/guide-for-health-professionals-addressing-oral-care-for-individuals-in-oncological-treatment-based-on-scientific-evidence
#2
Caroline Gomes Carvalho, João Batista Medeiros-Filho, Meire Coelho Ferreira
OBJECTIVE: Oncological treatment can cause changes in the oral cavity compromising oral functions. The aim of the study was, based on a systematic review, to draft a guide directed at the team of health professionals involved in the oral care of oncological patients. METHODS: A systematic search of the literature was performed for articles published between 2000 and April 2017. Searches were made of electronic databases and hand search. The inclusion criteria were systematic reviews of randomized clinical trials (RCTs) and RCTs published in English, involving pediatric and adult oncological patients and focused on the prevention and treatment of oral complications as well as studies addressing the maintenance of oral health...
February 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29468898/paratonia-in-flemish-nursing-homes-current-state-of-practice
#3
Bieke Van Deun, Nele Van den Noortgate, Saucedo Cinthia, Anke Van Bladel, Cambier Dirk
BACKGROUND: Paratonia is a major underlying motor problem impeding functionality and locomotion in dementia. Despite its undeniable impact on patient's quality of life and daily care, there is a lack of evidence-based therapy on patients with this condition. METHODS: We surveyed physiotherapists working in nursing homes in Flanders (Belgium) concerning the use and perceived effect of therapeutic strategies and positioning methods/aids. RESULTS: Positioning and soft passive mobilization were the most applied and positively appraised therapeutic interventions...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29468104/cerebellar-stroke-occupational-therapy-and-physical-therapy-management-from-intensive-care-unit-to-outpatient-a-case-report
#4
Christopher M Wilson, Christina L Mitchell, Katherine M Hebert
Cerebellar stroke increases the risk of extensive physical disability and long-term institutionalization. The purpose of this case report is to describe the 14-month longitudinal rehabilitation management and outcomes from the intensive care unit, inpatient rehabilitation unit and outpatient care of a patient after cerebellar stroke. A goal of this case report is to provide rehabilitation clinicians with a long-term perspective and understanding of the course of recovery for a patient after cerebellar cerebrovascular accident or related injury...
December 14, 2017: Curēus
https://www.readbyqxmd.com/read/29468084/a-development-study-and-randomised-feasibility-trial-of-a-tailored-intervention-to-improve-activity-and-reduce-falls-in-older-adults-with-mild-cognitive-impairment-and-mild-dementia
#5
Rowan H Harwood, Veronika van der Wardt, Sarah E Goldberg, Fiona Kearney, Pip Logan, Vicky Hood-Moore, Vicky Booth, Jennie E Hancox, Tahir Masud, Zoe Hoare, Andrew Brand, Rhiannon Tudor Edwards, Carys Jones, Roshan das Nair, Kristian Pollock, Maureen Godfrey, John R F Gladman, Kavita Vedhara, Helen Smith, Martin Orrell
Background: People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognition. Current falls prevention approaches are poorly suited to people with dementia, however, and are of uncertain effectiveness. We used multiple sources, and a co-production approach, to develop a new intervention, which we will evaluate in a feasibility randomised controlled trial (RCT), with embedded adherence, process and economic analyses...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29467192/combination-of-the-low-anticoagulant-heparin-cx-01-with-chemotherapy-for-the-treatment-of-acute-myeloid-leukemia
#6
Tibor J Kovacsovics, Alice Mims, Mohamed E Salama, Jeremy Pantin, Narayanam Rao, Ken M Kosak, Peter Ahorukomeye, Martha J Glenn, Michael W N Deininger, Kenneth M Boucher, Linda M Bavisotto, Gerardo Gutierrez-Sanchez, Thomas P Kennedy, Stephen G Marcus, Paul J Shami
Relapses in acute myelogenous leukemia (AML) are a result of quiescent leukemic stem cells (LSCs) in marrow stromal niches, where they resist chemotherapy. LSCs employ CXCL12/CXCR4 to home toward protective marrow niches. Heparin disrupts CXCL12-mediated sequestration of cells in the marrow. CX-01 is a low-anticoagulant heparin derivative. In this pilot study, we combined CX-01 with chemotherapy for the treatment of AML. Induction consisted of cytarabine and idarubicin (7 + 3) with CX-01. Twelve patients were enrolled (median age, 56 years; 3 women)...
February 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29465495/exercise-rehabilitation-for-peripheral-artery-disease-a-review
#7
Mary M McDermott
PURPOSE: To summarize evidence regarding exercise therapy for people with lower extremity peripheral artery disease (PAD). METHODS: Literature was reviewed regarding optimal strategies for delivering exercise interventions for people with PAD. Randomized trial evidence and recent studies were emphasized. RESULTS: Randomized clinical trial evidence consistently demonstrates that supervised treadmill exercise improves treadmill walking performance in people with PAD...
March 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29465107/sanatoria-revisited-sunlight-and-health
#8
I Greenhalgh, A R Butler
Since the 18th century tuberculosis has been a major cause of death throughout the world. It is a highly infectious disease that spreads by droplet infection and finding effective treatment to combat tuberculosis took a great deal of time. One of the first treatments to have some real success was a stay in a sanatorium. Sanatoria were homes that provided patients with good food and fresh air (and therefore sunlight). The first sanatorium to use sunlight therapy (heliotherapy) seriously was founded in Leysin, Switzerland, by Auguste Rollier...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29464907/weight-control-program-and-gestational-weight-gain-in-disadvantaged-women-with-overweight-or-obesity-a-randomized-clinical-trial
#9
Alison G Cahill, Debra Haire-Joshu, W Todd Cade, Richard I Stein, Candice L Woolfolk, Kelle Moley, Amit Mathur, Kenneth Schechtman, Samuel Klein
OBJECTIVE: This study aimed to evaluate the efficacy of a home-based lifestyle intervention delivered through Parents as Teachers (PAT) to reduce excessive gestational weight gain (GWG). METHODS: This was a single-blinded randomized controlled trial conducted as part of the LIFE-Moms consortium at a single university-based tertiary care institution from October 2012 to March 2016. There were 267 socioeconomically disadvantaged (SED) African American women with overweight or obesity (BMI 25...
March 2018: Obesity
https://www.readbyqxmd.com/read/29463793/aberrant-regulation-of-notch3-signaling-pathway-in-polycystic-kidney-disease
#10
Jessica Idowu, Trisha Home, Nisha Patel, Brenda Magenheimer, Pamela V Tran, Robin L Maser, Christopher J Ward, James P Calvet, Darren P Wallace, Madhulika Sharma
Polycystic kidney disease (PKD) is a genetic disorder characterized by fluid-filled cysts in the kidney and liver that ultimately leads to end-stage renal disease. Currently there is no globally approved therapy for PKD. The Notch signaling pathway regulates cellular processes such as proliferation and de-differentiation, which are cellular hallmarks of PKD. Thus we hypothesized that the Notch pathway plays a critical role in PKD. Evaluation of protein expression of Notch signaling components in kidneys of Autosomal Recessive PKD (ARPKD) and Autosomal Dominant PKD (ADPKD) mouse models and of ADPKD patients revealed that Notch pathway members, particularly Notch3, were consistently upregulated or activated in cyst-lining epithelial cells...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463192/home-based-exercise-for-elderly-patients-with-intermittent-claudication-limited-by-osteoarticular-disorders-feasibility-and-effectiveness-of-a-low-intensity-programme
#11
Nicola Lamberti, Sofia Straudi, Efisio Lissia, Lorenza Cavazzini, Sergio Buja, Roberto Manfredini, Nino Basaglia, Fabio Manfredini
BACKGROUND: Peripheral arterial disease (PAD) is a common cardiovascular pathology affecting mobility in elderly. Osteoarticular diseases (ODs), responsible for functional limitations and confounding leg symptoms, may interfere with exercise therapy. This study evaluates the feasibility and effectiveness of a structured home-based exercise programme on rehabilitative outcomes in a cohort of elderly PAD patients with and without coexisting ODs. PATIENTS AND METHODS: Patients were enrolled from 2002 to 2016 in an exercise programme prescribed and controlled at the hospital and based on two daily 10-minute home walking sessions below the self-selected speed...
February 21, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29463099/factors-associated-with-uptake-of-home-based-hiv-counselling-and-testing-and-hiv-care-services-among-identified-hiv-positive-persons-in-masaka-uganda
#12
Eugene Ruzagira, Kathy Baisley, Anatoli Kamali, Heiner Grosskurth
We investigated uptake of home-based HIV counselling and testing (HBHCT) and HIV care services post-HBHCT in order to inform the design of future HBHCT programmes. We used data from an open-label cluster-randomised controlled trial which had demonstrated the effectiveness of a post-HBHCT counselling intervention in increasing linkage to HIV care. HBHCT was offered to adults (≥18 years) from 28 rural communities in Masaka, Uganda; consenting HIV-positive care naïve individuals were enrolled and referred for care...
February 20, 2018: AIDS Care
https://www.readbyqxmd.com/read/29461863/home-parenteral-nutrition-for-patients-with-intestinal-failure-due-to-advanced-cancer
#13
Krista Murray, Shameer Mehta
Patients who experience intestinal failure as a result of advanced malignancy can be supported with parenteral nutrition in their own home (HPN). This article describes how to identify which cancer patients would benefit from this therapy and how to ensure it is safely and correctly administered in the home setting.
February 1, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29461340/attitudes-about-cognitive-screening-a-survey-of-home-care-physical-therapists
#14
Jean D Miles, William H Staples, Daniel J Lee
BACKGROUND AND PURPOSE: Home care physical therapists (PTs) are inconsistent regarding cognitive screening, possibly because screening tools were traditionally considered the domain of other home care disciplines, or because therapists perceive their dementia training to be inadequate. A cross sectional study was designed to survey home care therapists' attitudes and beliefs about the management of persons with dementia and to find out whether any specific cognitive tools or measures are currently used...
February 14, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29461122/synchronous-delivery-of-oxygen-and-photosensitizer-for-alleviation-of-hypoxia-tumor-microenvironment-and-dramatically-enhanced-photodynamic-therapy
#15
Xiaomeng Guo, Jiaxin Qu, Chunqi Zhu, Wei Li, Lihua Luo, Jie Yang, Xiaoyi Yin, Qingpo Li, Yongzhong Du, Dawei Chen, Yunqing Qiu, Yan Lou, Jian You
Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoral microenvironment is a major barrier hindering photodynamic reactions in vivo. Thus, we have prepared biocompatible liposomes by loading complexes of oxygen-carrier (hemoglobin, Hb) and photosensitizer (indocyanine green, ICG) for enhanced PDT against hypoxic tumor. Ideal oxygen donor Hb, which is an oxygen-carried protein in red blood cells, makes such liposome which provide stable oxygen supply...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29459219/home-blood-pressure-guided-antihypertensive-therapy-in-chronic-kidney-disease-more-data-are-needed
#16
EDITORIAL
Panagiotis I Georgianos, Eleni Champidou, Vassilios Liakopoulos, Elias V Balaskas, Pantelis E Zebekakis
In the era of newly introduced hypertension guidelines recommending lower blood pressure (BP) targets for drug-treated hypertensives, the necessity for optimized management of hypertension becomes even more urgent. The concept of home BP-guided antihypertensive therapy is for long suggested as a simple and feasible approach to improve BP control rates and optimize the management of hypertension. Home BP-guided antihypertensive therapy is particularly applicable to hypertensives with chronic kidney disease (CKD) for several reasons including the following: (1) difficult-to-control BP and high BP variability in the CKD setting; (2) poor accuracy of office BP in determining hypertension control status and detecting "white-coat" and "masked" hypertension; (3) poor value of routine office BP recordings in predicting the longitudinal progression of target-organ damage; and (4) superiority of home BP over office BP recordings in prognosticating the risk of incident end-stage renal disease or death...
February 10, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29458922/massage-therapy-for-home-care-patients-using-the-health-insurance-system-in-japan
#17
H Kondo, S Ogawa, H Nishimura, A Ono
OBJECTIVES: To clarify the status of home care massage services provided to patients. This will help in understanding how many patients utilize this service and the circumstances under which treatment is provided. DESIGN: A retrospective study. SETTING: Fifty-four acupuncture, moxibustion, and massage clinics. Participants were patients who had received home care massage for six months or more. We collected a total of 1587 responses from these 54 massage clinics; of these, 1415 responses (mean age = 79...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29457946/the-provision-of-ambulatory-systemic-anti-cancer-therapy
#18
Susan Cooper, Kate de Lord
This article reflects on the changing nature of the provision of care and delivery of ambulatory systemic anti-cancer therapy (SACT) services. It reviews the national guidance and looks at ambulatory SACT in terms of patients being treated closer to home, i.e. ambulatory care in its truest sense. It considers the impact on quality of life for patients receiving treatments at a place of their choice. It explores the role of the nurse as an advanced practitioner while also examining the safety and delivery of complex regimens ensuring robust pathways are in place to deliver care in a safe and standardised way...
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29457521/relationships-between-race-ethnicity-and-health-care-utilization-among-older-post-acute-home-health-care-patients
#19
Jo-Ana D Chase, David Russell, Liming Huang, Alexandra Hanlon, Melissa O'Connor, Kathryn H Bowles
Few studies have explored racial/ethnic differences in health care outcomes among patients receiving home health care (HHC), despite known differences in other care settings. We conducted a retrospective cohort study examining racial/ethnic disparities in rehospitalization and emergency room (ER) use among post-acute patients served by a large northeastern HHC agency between 2013 and 2014 ( N = 22,722). We used multivariable binomial logistic regression to describe the relationship between race/ethnicity and health care utilization outcomes, adjusting for individual-level factors that are conceptually related to health service use...
February 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29456886/heterogenic-transplantation-of-bone-marrow-derived-rhesus-macaque-mesenchymal-stem-cells-ameliorates-liver-fibrosis-induced-by-carbon-tetrachloride-in-mouse
#20
Xufeng Fu, Bin Jiang, Bingrong Zheng, Yaping Yan, Junfeng Wang, Yanchao Duan, Shanshan Li, Li Yan, Hong Wang, Bingbing Chen, Xiongbo Sang, Weizhi Ji, Ren-He Xu, Wei Si
Liver fibrosis is a disease that causes high morbidity and has become a major health problem. Liver fibrosis can lead to the end stage of liver diseases (livercirrhosisand hepatocellularcarcinoma). Currently, liver transplantation is the only effective treatment for end-stage liver disease. However, the shortage of organ donors, high cost of medical surgery, immunological rejection and transplantation complications severely hamper liver transplantation therapy. Mesenchymal stem cells (MSCs) have been regarded as promising cells for clinical applications in stem cell therapy in the treatment of liver diseases due to their unique multipotent differentiation capacity, immunoregulation and paracrine effects...
2018: PeerJ
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